Hub : Genes

FREM2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.7590	0.0290	0.00000	0.607	0.518	0.651	0.659	0.657	1.2e-93	1.9e-73	3.4e-105	2.1e-107	6.0e-107
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0477	0.0214	0.00190	0.006	0.007	-0.001	NA	0.000	6.6e-02	5.5e-02	4.7e-01	NA	2.9e-01
3	TCGA	Brain Lower Grade Glioma	0.0697	0.0288	0.00033	0.013	0.035	0.042	NA	0.031	1.2e-02	6.2e-05	1.4e-05	NA	1.8e-04
4	TCGA	Thyroid Carcinoma	0.0550	0.0270	0.00800	0.014	0.014	0.005	NA	0.015	1.3e-02	1.3e-02	9.0e-02	NA	1.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.6	0.4	-0.1	-0.8	-0.7
Bipolar Disorder or Schizophrenia	0.3	0.8	1.9	1.4	-0.2	0.2	-1.1
Depressed Affect (Nagel 2018)	0.5	1.0	2.9	1.7	0.2	0.5	0.9
Depression (Nagel 2018)	1.2	1.8	4.0	-2.0	0.8	-1.5	-0.6
Intelligence (Savage-Jansen 2018)	1.8	5.5	8.8	-1.5	2.7	-3.0	-1.9
Neuroticism (Nagel 2018)	0.2	0.4	0.7	0.6	0.2	-0.8	0.9
Schizophrenia (2018)	0.5	1.0	2.1	1.5	-0.2	0.9	-0.9
Schizophrenia vs Biploar Disorder	0.2	0.2	0.3	-0.3	0.6	-0.6	0.3
Worry (Nagel 2018)	0.1	0.2	0.9	-0.0	-0.0	-0.9	-0.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	0.1	0.7	-1.0	-1.0
Alzheimer’s Disease (in father)	1.6	1.8	3.9	-1.0	-1.1	-2.0	-1.0
Alzheimer’s Disease (including proxy)	0.9	1.3	3.0	-0.3	-0.3	-1.4	-1.7
Crohns Disease (2017)	0.3	0.5	1.4	-1.2	-0.3	-0.1	0.8
Irritable Bowel Disease (IBD)	0.1	0.1	0.3	-0.5	-0.6	-0.1	0.2
Ulcerative Colitis (UC)	0.3	0.6	1.2	-0.2	-0.7	-0.8	-1.1
Major Depression (MDD)	0.6	0.7	2.5	-0.2	0.2	-0.3	-1.6
Reaction Time	1.0	1.9	3.0	-1.4	-1.2	-1.7	-1.2
Verbal and Numeric Reasoning (VNR)	2.0	4.7	8.7	-2.7	-0.1	-3.0	-1.6
Breast Cancer	0.4	1.1	1.9	1.1	-0.8	0.7	1.4
Ovarian Cancer	1.1	1.5	2.5	1.6	0.5	0.9	1.6
Prostate Cancer	0.8	1.2	2.1	-1.0	-1.4	-0.6	-1.1
Age at First Birth	0.3	0.4	1.0	0.7	0.4	1.0	0.1
Bipolar Disorder (2011)	0.8	0.8	1.9	1.4	0.4	1.0	0.3
Body Mass Index (BMI) (2010)	0.6	0.9	2.1	0.9	-1.4	0.7	-0.2
Coronary Artery Disease (CAD)	0.5	0.5	1.2	0.8	0.6	1.1	0.3
Crohns Disease (2012)	0.7	1.1	2.2	-1.5	0.4	-0.7	-1.2
Mean Putamen Volume	0.4	0.5	0.9	-0.8	-0.2	-0.7	-0.9
Fasting Glucose	0.1	0.1	0.2	-0.4	0.0	-0.2	-0.4
HbA1C	0.2	0.2	0.5	0.5	-0.7	-0.1	-0.1
HDL Cholesterol	0.1	0.2	0.4	0.1	0.2	0.6	0.6
LDL Cholesterol	0.6	1.0	1.7	-1.0	0.6	-1.0	-1.3
Lupus	0.2	0.2	0.8	-0.1	0.9	0.0	0.3
Neuroticism (2016)	1.4	2.1	5.0	-1.5	-1.0	-2.2	0.0
Primary Biliary Cirrhosis	2.0	2.8	4.2	-0.7	-2.1	-1.9	1.7
Rheumatoid Arthritis	1.9	2.7	5.8	-2.4	-0.0	-1.7	-1.4
Schizophrenia (2014)	0.3	0.8	1.5	1.2	0.1	0.4	-1.2
Triglycerides	0.3	0.5	1.3	0.3	0.6	-0.7	1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.3	0.7	0.8	1.2	0.6
Ulcerative Colitis	0.6	0.9	2.9	0.1	-0.1	0.7	-1.7
Blood Eosinophil Count	0.1	0.5	2.0	0.0	-1.4	0.4	0.0
Blood Platelet Count	0.0	0.1	0.2	0.5	-0.1	0.3	0.3
Blood Red Count	0.1	0.8	1.8	1.3	0.3	-0.3	1.1
Blood White Count	0.1	0.8	1.8	0.3	-1.3	0.5	-1.0
Heel T-Score	0.2	1.5	5.0	0.5	-2.2	0.3	0.9
BMI	0.5	2.8	7.2	1.0	-2.7	1.7	0.2
Height	0.1	2.9	10.3	-0.7	-0.8	0.1	-3.2
Waist Hip Ratio (WHR)	0.6	2.9	6.5	-1.3	-1.2	-2.6	-1.4
Systolic Blood Pressure	0.7	3.5	5.4	1.9	0.6	2.3	2.2
Smoking Status	0.7	1.7	3.7	-0.8	-1.9	-0.4	-1.5
Allergy or Eczema	0.1	0.2	0.8	-0.1	0.3	-0.9	-0.1
Cardiovascular Disease	0.3	1.0	3.6	0.6	-0.0	1.9	0.1
Hypothyroidism (self reported)	0.5	1.1	1.8	1.1	0.3	1.1	1.3
Respiratory disease	0.2	0.5	1.2	-0.7	-0.3	-0.1	-1.1
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.2	-1.8	-1.1	-0.5	-0.8
Lung FEV1/FVC ratio	0.4	2.3	4.0	-0.9	-2.0	-1.6	1.2
Lung FVC	0.1	0.6	1.5	1.0	1.2	0.3	0.2
Neuroticism	0.1	0.3	0.9	0.1	0.3	-0.9	0.5
Chronotype (morning person)	1.2	2.7	5.4	0.8	-2.3	2.0	-0.6
Hair Pigment	0.5	14.6	34.1	-5.8	-1.8	-4.3	-1.7
Tanning	0.1	0.7	1.6	0.9	0.7	1.3	0.2
Hand grip strength (left)	0.4	1.1	1.8	-1.1	0.7	-1.3	-1.0
Number of treatments/medications taken	0.3	0.6	0.9	-0.8	-0.9	0.9	-0.0
Average weekly spirits intake	0.7	0.9	1.8	0.9	0.3	1.3	0.9
Sensitivity / hurt feelings	0.3	0.5	1.0	0.9	1.0	0.2	0.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.6	-1.2	0.4	-1.2	-1.0
Hearing difficulty/problems: Yes	0.8	1.2	1.9	1.1	-1.4	0.1	1.4
Relative age of first facial hair	0.4	0.8	1.3	-1.0	0.6	-0.7	-1.2
Other serious medical condition/disability diagnosed by doctor	1.7	2.3	3.9	1.6	-2.0	1.5	0.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.5	-0.9	0.4	-1.2	-0.2
Ever had hysterectomy (womb removed)	0.1	0.2	0.3	-0.1	0.6	-0.5	-0.2
Systolic blood pressure, automated reading	0.9	2.6	5.3	2.3	0.5	1.9	1.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.1	-0.5	-0.6	0.1	-1.1
Angina	1.3	1.7	4.1	-1.4	0.6	-0.7	-2.0
Medication for hormone replacement therapy	0.6	0.6	1.3	-0.9	-0.7	-0.2	-1.1
Vitamin and mineral supplements	0.1	0.1	0.4	0.0	0.3	0.0	-0.7
Supplements: Zinc	0.5	0.5	1.0	0.8	-0.3	1.0	0.5
Medication: Co-codamol	0.8	1.0	2.1	1.4	-0.9	0.9	0.3
Medication: Metformin	0.6	0.9	2.2	-1.1	0.2	-0.5	-1.5
Diabetes (father)	0.2	0.2	0.3	-0.4	-0.6	0.5	0.4
Diabetes (mother)	3.5	4.5	7.8	2.7	-0.5	2.8	1.5
Severe depression (siblings)	0.2	0.2	0.4	0.5	0.6	0.6	-0.0
Pack years adult smoking proportion	0.1	0.2	0.5	0.2	0.7	-0.1	-0.3
Impedance of leg (right)	0.7	3.6	8.4	-2.9	-0.1	-2.4	0.5
Leg fat-free mass (left)	0.4	1.9	4.7	0.3	-1.1	1.2	-2.2
Trunk fat percentage	0.5	1.8	4.4	-0.2	-2.1	1.1	-1.3
Hand grip strength (right)	0.0	0.0	0.0	0.0	-0.1	-0.0	-0.0
Townsend deprivation index at recruitment	0.5	0.6	1.4	-0.5	-1.2	-0.1	0.9
Current tobacco smoking	0.4	0.6	1.3	-1.1	-0.6	-0.8	-0.2
Average weekly fortified wine intake	3.7	4.3	7.5	2.3	0.9	1.9	2.7
Maternal smoking around birth	1.7	2.4	3.1	-1.7	1.3	-1.7	-1.4
Fed-up feelings	0.9	1.6	3.5	1.9	-0.9	1.4	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.1	-1.0	0.1	-1.0	-1.0
Relative age voice broke	0.1	0.2	0.5	0.1	0.5	0.2	-0.7
Taking other prescription medications	0.4	0.6	1.0	-1.0	-0.8	0.5	-0.6
Age when periods started (menarche)	0.8	1.9	3.9	-1.4	1.2	-2.0	0.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.2	-0.7	0.4	-0.6	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.6	0.5	-0.6	1.1	1.3
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.9	0.7	-1.7	0.9	0.3
Qualifications: CSEs or equivalent	0.2	0.3	0.5	-0.3	-0.4	-0.7	0.6
Serious illness, injury or assault to yourself	0.3	0.3	0.9	-0.6	0.0	0.2	-0.9
High blood pressure	0.8	2.3	5.0	1.6	-0.6	2.2	1.1
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.7	0.1	0.2	-0.9	0.5
Multivitamins +/- minerals	0.2	0.2	0.4	0.6	0.2	0.5	-0.3
Stomach or abdominal pain in last month	0.2	0.2	0.5	-0.3	0.7	-0.6	0.1
Supplements: Glucosamine	0.6	0.8	2.6	0.6	0.1	0.2	1.6
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	6.3	1.0	-0.2	1.6	-2.5
Medication: Atenolol	1.1	1.4	2.0	1.3	1.4	1.2	0.6
Medication: Levothyroxine sodium	0.4	0.7	1.1	1.0	-0.6	0.9	0.6
Sitting height	0.2	1.3	2.6	-1.2	-0.9	-0.3	-1.6
Chronic bronchitis/emphysema (father)	0.8	0.9	2.6	0.8	0.5	1.6	-0.4
High blood pressure (mother)	0.1	0.1	0.2	0.4	-0.3	0.2	0.2
Body mass index (BMI)	0.7	2.9	5.0	1.3	-2.2	2.2	-0.6
Impedance of leg (left)	0.5	2.5	6.2	-2.5	-0.1	-1.9	0.4
Leg predicted mass (left)	0.3	1.8	4.2	0.4	-1.1	1.3	-2.0
Trunk fat mass	0.5	2.3	4.8	0.2	-2.2	1.5	-1.5
Waist circumference	0.5	1.9	4.5	-0.3	-1.7	0.4	-2.1
Number of incorrect matches in round	0.4	0.6	0.9	-1.0	-0.6	-0.7	0.8
Past tobacco smoking	0.8	1.4	3.3	-0.2	1.5	0.3	1.8
Alcohol usually taken with meals	0.3	0.4	0.8	0.2	-0.3	0.9	-0.9
Nervous feelings	0.8	1.5	2.8	-0.7	-1.7	-1.6	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	0.3	0.1	-0.4	-0.7
Hearing difficulty/problems with background noise	1.4	2.2	6.7	0.9	-2.6	0.8	0.8
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.2	-0.7	1.0	-0.4
Had menopause	1.3	1.6	4.9	-0.1	0.4	-1.1	-2.2
Had other major operations	1.2	1.4	2.9	1.7	0.9	1.3	-0.4
Forced vital capacity (FVC)	0.2	0.7	1.4	0.1	1.0	-0.6	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.1	1.8	-1.2	1.6	1.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.7	1.0	0.2	1.6	0.9
Qualifications: None of the above	0.3	0.6	1.2	0.3	-1.1	1.0	0.3
Financial difficulties in last 2 years	0.3	0.4	1.1	-1.0	-0.0	-0.1	-0.8
Mouth/teeth dental problems	0.3	0.5	1.1	-0.4	-1.0	-0.5	0.7
Heart attack	0.7	0.8	2.4	-0.8	-1.5	0.2	-0.5
Allergy	0.0	0.1	0.2	0.2	0.3	0.4	-0.1
Pain all over the body in last month	0.8	0.9	2.1	-0.2	1.5	-1.1	-0.4
Diabetes (self-reported)	1.5	2.3	4.3	-2.1	0.7	-1.4	-1.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.4	-0.2	-0.2	-1.0	1.2
Medication: Ramipril	0.4	0.5	1.0	-1.0	-0.8	-0.4	0.5
Medication: Simvastatin	0.1	0.1	0.3	0.3	-0.5	-0.0	0.4
Fluid intelligence score	0.4	0.9	2.2	-0.1	1.5	-1.1	-0.2
Illnesses of siblings	0.3	0.4	0.9	0.3	0.7	0.2	-1.0
Neuroticism score	0.1	0.3	0.6	0.8	-0.5	-0.2	-0.5
Weight	0.5	2.7	4.0	0.5	-1.9	1.7	-2.0
Impedance of arm (right)	0.4	1.8	3.9	-2.0	0.3	-1.5	-0.9
Arm fat percentage (right)	0.6	2.5	5.9	0.8	-2.4	1.7	-0.6
Trunk fat-free mass	0.2	1.1	1.9	0.8	-0.8	1.4	-1.1
Hip circumference	0.4	1.8	3.0	-0.0	-1.5	1.7	-1.4
Time employed in main current job	1.4	1.6	4.6	0.8	-2.1	0.8	0.6
Alcohol intake versus 10 years previously	0.8	1.2	2.5	-0.3	-0.3	-1.5	1.6
Father’s age at death	1.4	1.9	3.4	-0.2	1.7	-1.0	1.9
Worrier / anxious feelings	0.3	0.5	1.6	1.3	0.4	0.2	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.8	-0.5	0.2	-0.9	-0.8
Falls in the last year	0.9	1.2	2.5	0.3	-1.2	0.9	-1.6
Hair/balding pattern: Pattern 3	0.4	0.6	1.9	0.3	0.6	-0.3	1.4
Number of live births	0.1	0.2	0.3	-0.5	-0.5	-0.2	-0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.2	-0.4	-0.0	-1.1	-0.6
Pulse rate	0.5	0.9	1.5	1.2	0.8	1.0	-0.6
Happiness	1.2	1.5	2.2	-0.4	1.4	-1.5	1.3
Noisy workplace	0.5	0.6	1.3	0.3	-1.1	0.4	-1.0
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.8	1.1	-0.5	1.4	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.7	-0.2	0.5	-0.0
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	-0.6	-0.9	-0.1	0.3
Asthma	0.2	0.5	1.3	-0.4	0.6	0.0	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.2	1.2	-0.6	1.5	0.9
Medication: Cholesterol lowering	0.2	0.4	1.4	-0.4	-1.2	0.1	-0.2
Depression (self-reported)	2.3	2.8	5.3	-2.3	0.8	-2.1	-0.8
Medication: Lansoprazole	1.2	1.4	2.4	-1.4	-0.7	-1.5	-0.8
Prospective memory result	0.5	0.6	2.1	-0.4	0.2	-0.2	1.5
Lung cancer (father)	0.9	1.1	2.1	-1.5	0.9	-1.2	-0.2
Illnesses of mother	0.2	0.3	0.5	-0.6	0.3	-0.7	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.4	-0.8	0.6	-1.4	-1.5
Pulse wave Arterial Stiffness index	0.1	0.1	0.4	0.7	0.4	0.1	-0.1
Impedance of arm (left)	0.5	2.2	4.7	-2.2	0.2	-1.3	-1.5
Arm fat mass (right)	0.6	2.5	4.5	0.8	-2.1	1.8	-1.3
Trunk predicted mass	0.2	1.1	2.2	0.8	-0.8	1.5	-1.0
Standing height	0.3	3.0	9.1	-1.5	0.3	-0.6	-3.0
Length of working week for main job	0.5	0.5	1.2	-0.7	-0.4	-1.1	0.4
Exposure to tobacco smoke at home	2.1	2.3	6.5	-2.5	-0.2	-1.4	-0.9
Breastfed as a baby	0.5	0.7	2.1	1.4	-0.5	-0.1	0.5
Tense / ‘highly strung’	0.1	0.1	0.2	0.4	-0.2	-0.5	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.7	0.1	0.8	-0.3	0.0
Hair/balding pattern: Pattern 4	0.7	1.8	3.2	1.8	1.6	0.9	-0.7
Birth weight of first child	1.1	1.9	4.6	-1.4	0.4	-2.1	-1.0
Peak expiratory flow (PEF)	0.7	1.5	2.6	-1.6	-0.6	-1.6	0.8
Pulse wave reflection index	0.5	0.7	1.7	0.9	0.1	-0.2	1.3
Ever highly irritable/argumentative for 2 days	0.9	1.0	1.7	-1.3	-0.9	-1.1	0.5
Loud music exposure frequency	1.8	1.9	7.1	-0.7	0.1	0.2	-2.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	-0.4	0.8	0.1	-0.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.9	-1.0	0.6	0.2	-1.7
Blood clot in the leg (DVT)	0.3	0.4	0.8	-0.9	0.4	0.0	0.7
Medication: Paracetamol	0.7	1.1	2.2	-1.5	-0.4	0.5	-1.3
Headache pain in last month	0.6	1.1	2.0	-1.4	-1.1	-0.4	0.9
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.3	-0.3	1.1	-0.6	-0.1
Glaucoma (self-reported)	0.1	0.1	0.2	0.5	0.3	0.2	0.2
Gout (self-reported)	0.2	0.3	1.1	0.0	-1.0	0.4	0.1
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.4	0.8	-0.7	1.2	1.1
Medication: Amlodipine	0.1	0.2	0.2	-0.5	0.4	-0.1	0.5
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.0	-0.7	1.0	-1.0	0.5
Birth weight	0.8	1.7	4.2	1.4	2.0	0.3	0.8
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.5	0.7	0.7	0.6	0.4
High blood pressure (siblings)	0.2	0.3	0.8	0.9	0.1	0.8	0.1
Forced vital capacity (FVC), Best measure	0.7	2.4	4.0	-1.0	1.6	-1.5	-2.0
Body fat percentage	0.6	2.4	6.2	0.1	-2.5	1.4	-1.1
Leg fat percentage (right)	0.5	1.9	5.6	0.3	-2.4	1.4	-0.4
Arm fat-free mass (right)	0.2	1.1	2.4	0.2	-1.2	0.9	-1.5
Exposure to tobacco smoke outside home	1.5	2.0	4.4	-2.1	-1.0	-1.5	-0.4
Comparative body size at age 10	0.9	2.5	5.5	2.3	-0.6	2.0	0.7
Number of full brothers	1.2	1.5	5.9	-0.1	-2.4	-0.1	-0.2
Worry too long after embarrassment	0.5	0.8	1.9	0.0	0.5	-1.4	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.2	-1.1	0.4	-1.1	-0.5
Wheeze or whistling in the chest in last year	1.8	3.3	11.2	-0.8	-1.2	0.1	-3.3
Number of children fathered	0.3	0.3	1.2	0.2	1.1	-0.1	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.3	-0.1	-0.0	0.1	1.1
Age at first live birth	1.2	2.2	4.0	2.0	-0.0	1.9	1.0
Pulse wave peak to peak time	0.3	0.3	1.0	-1.0	-0.3	-0.5	-0.2
Health satisfaction	0.1	0.1	0.3	-0.5	0.0	-0.2	0.4
Shortness of breath walking on level ground	0.8	0.9	2.4	-0.9	-0.1	-1.5	-0.7
Qualifications: College or University degree	0.1	0.4	1.4	0.3	-0.2	0.1	-1.2
Eye problems/disorders: None of the above	0.7	0.8	2.3	-1.5	0.7	-0.6	0.3
Mouth/teeth dental problems: Loose teeth	1.4	1.7	4.4	0.5	-1.1	2.1	-0.9
Emphysema/chronic bronchitis	0.2	0.2	0.3	0.5	-0.6	0.5	-0.1
Medication for pain relief, constipation, heartburn	0.4	0.7	1.6	0.2	0.8	-1.3	0.5
Neck or shoulder pain in last month	1.4	1.9	3.1	1.8	1.5	1.5	-0.1
Medication: Blood pressure	1.3	2.3	4.0	1.0	-2.0	1.4	1.6
Angina (self-reported)	1.2	1.6	4.3	-1.2	0.5	-0.7	-2.1
Migraine (self-reported)	0.6	0.7	0.9	-1.0	0.9	0.9	-0.6
Medication: Ibuprofen	0.5	0.6	1.5	0.7	-0.2	1.2	0.7
Medication: Allopurinol	1.6	2.1	2.8	1.6	-1.4	1.1	1.7
Medication: Omeprazole	0.9	1.0	3.2	0.4	-0.5	0.7	-1.8
Medication: Seretide 50 evohaler	0.3	0.4	1.1	0.3	-0.4	0.5	1.0
Mean time to correctly identify matches	0.6	1.1	2.2	-0.8	-1.0	-1.5	-0.8
Heart disease (mother)	0.3	0.4	0.8	-0.3	-0.6	-0.9	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.2	1.0	0.2	0.4	1.1
Whole body fat mass	0.6	2.4	5.3	0.5	-2.3	1.5	-1.3
Leg fat mass (right)	0.6	2.4	5.8	0.4	-2.4	1.5	-1.1
Arm predicted mass (right)	0.2	1.2	3.1	0.2	-1.0	0.9	-1.8
Pulse rate, automated reading	0.4	1.2	4.2	2.0	0.4	0.7	-0.2
Alcohol intake frequency.	0.2	0.5	1.2	-0.9	-0.2	-0.3	-1.1
Comparative height size at age 10	0.3	1.4	2.0	-1.4	1.4	-0.7	-1.1
Number of full sisters	0.6	0.7	1.3	-0.9	0.7	-0.4	-1.1
Suffer from ‘nerves’	0.4	0.6	1.9	-0.6	-1.4	-0.1	0.2
Overall health rating	0.2	0.4	1.5	0.1	-1.2	0.3	-0.3
Chest pain or discomfort	0.5	0.7	1.8	-0.8	-0.6	-0.3	-1.3
Had major operations	0.3	0.3	0.7	0.6	-0.4	0.9	0.1
Age at last live birth	0.7	1.0	2.2	1.2	-0.4	0.4	1.5
Family relationship satisfaction	1.3	1.6	4.6	0.8	-0.9	-0.5	2.2
Leg pain on walking	0.3	0.4	0.9	0.3	-0.6	1.0	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	0.6	0.4	-0.1	0.6
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	-0.6	-0.4	0.1	0.2
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	5.9	1.8	0.9	0.8	2.4
Medication: Aspirin	0.4	0.5	1.8	-1.3	0.5	-0.0	0.3
Supplements: Vitamin C	0.4	0.5	1.2	-0.6	-1.1	-0.5	0.4
Knee pain experienced in last month	0.1	0.2	0.5	-0.2	-0.7	0.2	-0.3
Hypertension (Self-reported)	0.5	1.3	3.1	1.1	-0.5	1.8	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.5	0.7	-0.8	0.4	-1.2
Illnesses of father: Heart disease	0.8	1.1	1.7	1.3	1.0	1.3	0.3
Illnesses of siblings: Diabetes	0.4	0.5	1.3	-1.1	-0.0	-0.4	-0.6
Smoking status: Previous	0.8	1.2	3.2	0.2	-1.0	-0.6	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.7	-0.3	-0.0	0.8	-0.8
Whole body fat-free mass	0.2	1.3	2.4	0.6	-0.8	1.3	-1.5
Leg fat-free mass (right)	0.4	2.0	4.0	0.8	-0.9	1.6	-2.0
Arm fat percentage (left)	0.7	2.7	5.8	0.8	-2.4	1.9	-0.9
Average weekly red wine intake	0.3	0.4	1.0	0.6	0.4	-0.4	-1.0
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.9	0.1	-1.0	0.4	-0.4
Mood swings	0.3	0.5	1.1	0.9	-1.1	-0.2	-0.3
Loneliness, isolation	0.8	1.1	1.4	1.0	-0.9	1.0	-1.2
Long-standing illness, disability or infirmity	0.8	1.3	2.9	-0.3	-1.7	1.1	0.9
Ever had bowel cancer screening	0.1	0.1	0.4	0.3	-0.6	-0.0	-0.3
Diabetes diagnosed by doctor	0.6	1.0	2.1	-1.4	0.5	-0.3	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.5	-0.0	-0.7	-0.3	0.0
Friendships satisfaction	0.5	0.6	1.5	0.8	-0.4	0.4	1.2
Qualifications: nursing, teaching	0.4	0.6	1.6	0.7	-0.0	1.3	-0.5
Commuting to job workplace: Walk	0.7	0.7	2.2	0.6	1.5	0.2	0.5
Eye problems/disorders: Cataract	1.2	1.4	3.3	1.8	-1.2	0.5	0.9
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	7.2	0.2	2.7	-1.0	-1.0
Medication for cholesterol	0.2	0.3	1.1	-0.1	0.3	-1.1	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.7	1.1	-0.8	1.6	0.1
Back pain experienced in last month	0.3	0.5	0.9	0.9	-0.9	0.5	-0.2
Mineral and other dietary supplements	0.4	0.5	1.1	0.5	-0.7	1.0	-0.3
Breast cancer (self-reported)	1.0	1.1	2.4	-1.3	-0.4	-1.5	-0.5
Asthma (self-reported)	0.1	0.2	0.7	-0.3	0.4	0.1	-0.9
Osteoporosis (self-reported)	0.4	0.4	0.8	-0.2	0.9	-0.8	0.5
Osteoarthritis (self-reported)	0.7	1.0	2.0	-0.8	-1.4	-0.4	-1.0
Medication: Aspirin	0.4	0.5	1.6	-1.3	0.5	0.1	0.3
Medication: Gliclazide	2.3	2.6	4.1	-2.0	0.9	-1.2	-2.0
Illnesses of father: None of the above (group 1)	1.4	1.8	3.4	-1.2	-1.5	-1.8	-0.2
Smoking status: Current	0.3	0.5	1.0	-1.0	-0.9	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.0	0.7	-0.1	1.0	-0.4
Whole body water mass	0.2	1.2	2.2	0.6	-0.9	1.3	-1.5
Leg predicted mass (right)	0.4	2.1	4.0	0.9	-1.0	1.6	-2.0
Arm fat mass (left)	0.6	2.3	4.3	0.7	-2.1	1.7	-1.2
Number of self-reported non-cancer illnesses	0.3	0.6	1.7	-0.4	-1.3	0.7	0.2
Average weekly champagne plus white wine intake	2.2	3.0	6.6	-2.6	0.4	-2.3	0.2
Miserableness	0.9	1.5	2.6	1.6	0.9	0.2	1.6
Guilty feelings	0.5	0.8	1.2	-1.0	-0.4	-0.9	-1.1
Wears glasses or contact lenses	1.7	1.9	3.5	1.9	1.6	0.3	1.2
Ever taken oral contraceptive pill	0.1	0.1	0.1	0.3	0.3	-0.2	0.0
Hearing aid user	0.4	0.5	1.1	0.8	0.5	0.2	-1.0
Mother’s age at death	0.3	0.3	0.6	0.8	-0.6	0.4	0.4
Financial situation satisfaction	0.2	0.3	0.7	-0.2	0.8	-0.1	0.6
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.3	0.3	-0.9	0.3	-1.5
Commuting to job workplace: Public transport	0.5	0.6	1.0	1.0	-0.9	0.2	-0.6
Eye problems/disorders: Glaucoma	0.3	0.4	0.6	0.8	0.8	-0.3	0.4
Medication: Blood pressure	0.2	0.4	0.8	0.3	0.9	0.9	-0.2
Pain type(s) experienced in last month: Hip pain	1.8	2.2	3.2	1.0	-1.8	1.4	-1.6
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.8	-0.9	1.1	-1.3	0.5
High cholesterol (Self-reported)	1.0	1.7	2.4	1.6	1.3	1.0	1.3
Medication: Bendroflumethiazide	0.5	0.7	1.3	1.1	-0.5	1.0	-0.3
Medication: Paracetamol	0.2	0.4	0.6	-0.8	0.4	0.7	-0.4
Medication: Lisinopril	0.4	0.6	1.2	0.8	0.2	1.1	0.6
Medication: Atorvastatin	0.3	0.3	1.1	-1.0	-0.1	0.4	-0.3
Illnesses of father: High blood pressure	0.6	0.8	1.6	0.2	1.1	0.4	1.3
Alcohol drinker status: Never	0.8	1.0	2.8	-0.8	-0.6	-0.1	-1.7
Ever smoked	0.5	0.9	2.0	0.9	-0.7	0.5	-1.4
Basal metabolic rate	0.3	1.8	2.9	0.6	-1.2	1.5	-1.7
Leg fat percentage (left)	0.7	2.4	6.1	0.6	-2.5	1.7	-0.4
Arm fat-free mass (left)	0.2	0.9	1.2	0.4	-1.1	1.1	-1.0
Number of operations (self-reported)	0.0	0.0	0.0	0.1	0.0	0.2	-0.0
Average weekly beer plus cider intake	0.7	1.0	2.2	-0.6	-0.6	-1.1	-1.5
Irritability	0.4	0.7	2.2	-0.5	0.5	-1.5	-0.1
Risk taking	2.2	3.3	8.1	-1.2	1.5	-1.1	2.9
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.8	0.3	1.3	0.0	1.3
Fractured/broken bones in last 5 years	0.6	0.8	2.6	-0.2	1.6	-0.5	0.6
Age started oral contraceptive pill	1.3	1.6	3.4	0.5	1.8	-0.8	1.5
Diastolic blood pressure, automated reading	1.9	5.7	9.7	3.1	1.3	2.6	2.2
Ever depressed for a whole week	1.0	1.2	3.0	0.0	-0.7	1.2	1.7
Unable to work because of sickness or disability	0.3	0.4	1.2	0.2	-1.1	0.0	0.4
Commuting to job workplace: Cycle	0.3	0.3	0.5	-0.7	0.6	-0.2	-0.5
Myopia	0.0	0.0	0.1	0.0	-0.3	0.0	0.1
Vascular/heart problems diagnosed by doctor	0.7	1.9	4.5	-1.2	1.0	-2.1	-0.8
Cholesterol lowering medication	0.7	1.0	1.5	1.0	0.0	1.2	1.1
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.4	-0.3	0.7	-0.4	-1.8
Pain experienced in last month	0.4	0.7	1.4	-0.2	0.6	-1.0	-1.2
Supplements: Calcium	0.7	0.8	2.0	-0.7	0.2	-1.4	0.8
Basal cell carcinoma (self-reported)	1.5	1.8	2.9	0.6	1.6	1.2	-1.7
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.9	-0.9	-1.4	0.0	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.2	-1.1	0.5	-0.4	0.6
Heart disease (siblings)	0.2	0.2	0.6	-0.4	-0.8	-0.3	0.3
Alcohol drinker status: Previous	0.3	0.4	0.8	-0.5	-0.6	-0.3	-0.9
Pack years of smoking	0.1	0.2	0.5	0.3	0.7	-0.3	-0.3
Impedance of whole body	0.7	3.5	8.4	-2.9	0.2	-2.2	-0.9
Leg fat mass (left)	0.6	2.3	5.2	0.5	-2.3	1.6	-1.1
Arm predicted mass (left)	0.2	1.0	1.3	0.5	-1.1	1.1	-1.1