TWAS hub - FRG1B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1530	0.0710	7.5e-11	0.108	0.079	0.090	0.084	0.113	4.9e-13	8.0e-10	4.9e-11	1.8e-10	1.4e-13
2	GTEx	Adipose Subcutaneous	0.0560	0.0310	1.1e-04	0.041	NA	0.039	NA	0.038	2.5e-04	NA	3.6e-04	NA	4.0e-04
3	GTEx	Artery Tibial	0.0321	0.0168	2.8e-03	0.020	NA	0.020	NA	0.027	9.8e-03	NA	9.8e-03	NA	3.0e-03
4	GTEx	Brain Cerebellar Hemisphere	0.1550	0.0730	1.0e-03	0.063	NA	0.107	NA	0.079	1.0e-02	NA	1.1e-03	NA	4.6e-03
5	GTEx	Brain Cerebellum	0.1590	0.0770	2.6e-03	0.097	NA	0.074	NA	0.093	8.6e-04	NA	3.3e-03	NA	1.1e-03
6	GTEx	Breast Mammary Tissue	0.0560	0.0340	3.7e-03	0.028	NA	0.013	NA	0.019	1.4e-02	NA	7.0e-02	NA	3.4e-02
7	GTEx	Breast Mammary Tissue (Female)	0.0548	0.0357	2.9e-02	0.040	NA	-0.007	NA	-0.002	2.4e-02	NA	6.2e-01	NA	3.8e-01
8	GTEx	Cells Transformed fibroblasts	0.0490	0.0250	7.2e-04	0.040	NA	0.020	NA	0.031	5.3e-04	NA	1.1e-02	NA	2.2e-03
9	GTEx	Esophagus Gastroesophageal Junction	0.0860	0.0520	3.7e-03	0.037	NA	-0.001	NA	-0.008	1.7e-02	NA	3.4e-01	NA	8.9e-01
10	GTEx	Heart Atrial Appendage	0.0660	0.0340	1.4e-03	0.017	NA	0.006	NA	-0.002	5.6e-02	NA	1.7e-01	NA	4.1e-01
11	GTEx	Lung	0.0843	0.0345	7.8e-07	0.042	NA	0.052	NA	0.046	3.6e-04	NA	7.9e-05	NA	2.0e-04
12	GTEx	Muscle Skeletal	0.0647	0.0267	1.0e-07	0.093	NA	0.084	NA	-0.001	2.1e-09	NA	1.3e-08	NA	4.7e-01
13	GTEx	Nerve Tibial	0.0466	0.0260	2.4e-03	0.032	NA	0.036	NA	0.022	2.4e-03	NA	1.4e-03	NA	1.0e-02
14	GTEx	Skin Sun Exposed Lower leg	0.0290	0.0200	8.9e-03	-0.001	NA	0.006	NA	-0.002	3.7e-01	NA	9.4e-02	NA	5.7e-01
15	GTEx	Stomach	0.0530	0.0320	7.3e-03	0.066	NA	0.015	NA	0.038	4.3e-04	NA	6.2e-02	NA	6.5e-03
16	GTEx	Thyroid	0.0390	0.0240	4.0e-03	0.029	NA	0.007	NA	0.004	2.4e-03	NA	8.4e-02	NA	1.6e-01
17	METSIM	Adipose	0.0464	0.0203	1.6e-07	0.063	0.048	0.065	0.051	0.063	1.1e-09	1.0e-07	5.2e-10	3.8e-08	8.6e-10
18	ROSMAP	Brain Pre-frontal Cortex	0.0597	0.0235	1.2e-09	0.093	0.078	0.080	0.076	0.085	5.6e-12	3.1e-10	1.6e-10	5.3e-10	4.2e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Mean Putamen Volume	7.1	8.1	14.4	-2.4	-2.9	-2.8	-1.4	-1.7	1.5	-3.8	-3.6	-2.3	-2.7	-3.1	-2.6	-2.9	-2.6	-3.0	-3.6	-3.8	-3.0
Medication: Lisinopril	5.8	7.5	12.0	-2.7	-2.8	-2.9	-2.6	-2.3	2.3	-3.0	-3.1	-2.3	-2.6	-3.5	-2.6	-2.8	-2.3	-2.3	-2.8	-3.1	-2.9
Unable to work because of sickness or disability	5.4	7.0	9.8	-2.4	-2.4	-3.0	-2.5	-2.9	1.9	-3.1	-2.8	-2.3	-2.6	-3.0	-2.5	-2.7	-2.0	-1.6	-3.0	-3.0	-3.1
Medication: Gliclazide	5.2	5.8	9.4	-2.3	-2.5	-2.4	-1.4	-0.7	2.1	-2.2	-2.9	-2.5	-2.6	-2.5	-2.6	-1.8	-3.1	-3.0	-2.9	-2.5	-2.3
Stomach or abdominal pain in last month	5.1	6.3	9.2	-1.9	-2.5	-2.8	-2.6	-1.3	2.9	-2.8	-2.6	-2.8	-3.0	-2.8	-3.0	-1.8	-1.8	-1.9	-2.4	-2.7	-2.6
Triglycerides	4.9	8.0	16.8	-2.6	-2.8	-2.6	-2.0	-1.3	2.9	-2.6	-3.0	-2.5	-2.6	-3.0	-3.0	-2.0	-4.1	-3.8	-3.3	-2.6	-3.0
Length of working week for main job	4.6	5.0	8.6	-2.3	-2.1	-2.2	-1.1	-1.4	2.1	-2.4	-2.5	-2.1	-2.2	-2.9	-2.1	-2.8	-1.9	-1.9	-2.5	-2.4	-2.6
Medication: Omeprazole (e.g. Zanprol)	4.1	5.0	9.9	-2.4	-2.1	-2.5	-1.7	-2.2	1.6	-2.1	-1.9	-2.4	-2.5	-3.0	-1.9	-3.1	-1.7	-1.4	-2.6	-2.1	-2.3
Supplements: Zinc	4.0	4.4	5.9	-2.0	-2.2	-2.3	-1.8	-2.0	1.4	-2.4	-2.4	-1.9	-2.1	-2.4	-2.2	-1.6	-2.0	-1.7	-2.3	-2.4	-2.2
Medication for cholesterol, blood pressure or diabetes	3.8	6.4	10.4	2.8	2.8	2.3	1.4	0.8	-2.1	2.4	2.9	2.2	2.4	3.1	2.5	2.5	2.6	3.2	3.1	2.6	2.5
Loud music exposure frequency	3.7	4.1	7.9	-2.8	-2.3	-2.1	-1.2	-0.9	1.9	-1.9	-1.5	-2.4	-2.4	-2.5	-2.3	-2.6	-1.6	-0.7	-1.7	-1.8	-2.1
Heart disease (siblings)	3.7	4.5	6.7	-2.5	-2.4	-2.2	-1.1	-0.5	1.8	-2.0	-2.2	-2.5	-2.5	-2.6	-2.4	-2.4	-1.8	-1.8	-2.3	-2.1	-2.0
Number of treatments/medications taken	3.6	6.4	10.2	-2.6	-2.6	-2.8	-2.6	-2.2	2.5	-2.2	-2.6	-2.4	-2.6	-3.2	-2.3	-2.8	-2.0	-2.4	-2.6	-2.3	-2.5
Medication: Paracetamol	3.6	5.9	8.5	-2.7	-2.9	-2.3	-1.4	-0.6	1.9	-2.3	-2.6	-2.4	-2.6	-2.9	-2.6	-2.5	-2.4	-2.8	-2.6	-2.4	-2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.6	4.3	8.9	1.7	1.9	2.6	1.8	2.5	-1.3	2.3	2.1	2.0	2.2	2.6	1.7	3.0	1.6	0.9	2.3	2.3	1.9
Eye problems/disorders: Cataract	3.6	4.2	6.6	2.6	2.5	2.2	1.4	1.2	-1.8	2.3	2.0	2.2	2.2	2.0	2.3	2.3	1.3	1.5	2.0	2.2	2.3
Respiratory disease	3.4	7.6	13.6	3.1	3.1	2.1	1.2	-0.3	-2.4	3.2	3.2	2.3	2.7	2.6	3.3	1.4	3.7	3.4	2.6	3.2	3.3
Medication for pain relief, constipation, heartburn	3.4	5.7	9.8	2.4	2.4	2.3	1.2	0.8	-1.8	2.5	2.8	2.4	2.6	3.1	2.3	2.3	2.0	3.0	2.7	2.6	2.5
Blood Platelet Count	3.3	38.8	114.5	-10.7	-6.9	-6.1	-7.0	-3.4	5.2	-4.8	-5.6	-6.2	-6.3	-7.6	-7.3	-5.8	-5.1	-5.0	-4.4	-5.1	-6.0
High cholesterol (Self-reported)	3.1	5.6	8.5	-2.9	-2.5	-2.3	-2.2	-1.4	2.4	-2.0	-2.2	-2.2	-2.2	-2.8	-2.1	-2.6	-2.5	-2.7	-2.6	-2.0	-2.5
Number of live births	3.0	4.3	6.9	1.9	1.9	2.0	1.2	1.0	-1.7	2.5	2.6	1.7	2.0	2.1	2.1	1.9	2.0	2.1	2.5	2.6	2.5
Pain experienced in last month	3.0	5.0	8.8	1.7	2.3	3.0	2.6	2.2	-2.4	1.9	1.8	2.9	2.9	2.7	2.5	2.3	1.0	0.7	2.0	2.0	2.0
Medication: Metformin	2.9	4.1	7.2	-1.6	-1.7	-1.9	-2.3	-1.7	2.0	-2.3	-2.6	-1.1	-1.5	-2.3	-1.5	-1.7	-1.9	-2.7	-2.0	-2.4	-2.4
Medication: Blood pressure	2.9	5.2	11.2	-2.5	-2.6	-1.8	-0.7	-0.6	1.3	-2.6	-3.1	-1.5	-1.8	-2.8	-2.1	-1.8	-2.3	-3.3	-2.8	-2.7	-2.4
Medication: Omeprazole	2.9	3.5	8.2	-1.7	-1.5	-2.2	-1.8	-2.3	1.6	-1.6	-1.4	-2.0	-2.1	-2.5	-1.3	-2.9	-1.1	-0.8	-2.1	-1.6	-1.9
Long-standing illness, disability or infirmity	2.9	4.5	8.4	-1.5	-1.4	-2.5	-2.4	-2.4	2.0	-1.9	-2.2	-2.0	-2.1	-2.9	-1.7	-2.0	-1.3	-2.0	-2.7	-2.0	-2.2
Blood Red Count	2.7	26.1	41.5	-6.0	-6.0	-4.0	-2.0	0.8	5.0	-5.0	-5.6	-4.9	-5.2	-5.8	-6.2	-3.3	-6.4	-6.4	-4.8	-5.1	-5.5
Exposure to tobacco smoke outside home	2.7	3.6	7.5	-2.7	-2.7	-1.8	-0.3	-0.5	1.1	-1.7	-1.3	-2.2	-2.2	-2.4	-2.1	-2.7	-1.9	-0.5	-2.1	-1.6	-1.5
Breast cancer (self-reported)	2.7	3.2	6.9	-1.7	-1.8	-2.0	-1.5	-1.7	0.3	-2.5	-2.4	-1.3	-1.7	-1.8	-1.7	-1.8	-1.0	-1.0	-1.6	-2.6	-1.8
Asthma (self-reported)	2.7	5.5	9.9	2.5	2.7	1.6	1.0	-0.1	-1.8	3.1	2.9	1.6	2.1	2.1	2.6	1.6	3.1	2.8	2.3	2.9	2.9
Heart attack/myocardial infarction (self-reported)	2.7	3.5	5.3	-2.2	-1.9	-1.9	-1.5	-1.2	1.9	-1.9	-2.1	-1.7	-1.8	-2.1	-2.0	-1.6	-1.4	-2.0	-1.7	-1.9	-2.3
Medication: Seretide 50 evohaler	2.6	3.0	5.1	2.2	2.2	1.9	2.0	1.5	-1.8	1.6	1.1	1.9	1.9	1.5	1.9	2.1	1.3	-0.1	1.4	1.5	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.2	5.5	-2.3	-2.1	-1.4	-0.8	0.1	0.9	-1.7	-2.1	-1.4	-1.6	-2.1	-2.2	-1.3	-2.3	-2.3	-1.7	-1.9	-2.0
Asthma	2.4	4.8	9.4	2.2	2.5	1.4	0.9	-0.1	-1.6	2.9	2.7	1.4	1.9	2.0	2.4	1.5	3.1	2.7	2.2	2.8	2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.4	5.0	13.9	-1.6	-1.7	-1.4	-0.3	0.2	0.5	-3.3	-3.7	-1.1	-1.7	-1.8	-2.1	-0.3	-3.1	-3.7	-2.4	-3.4	-2.4
Serious illness, injury or assault to yourself	2.3	2.8	5.0	-2.2	-2.0	-1.7	-1.1	-2.1	0.7	-1.7	-1.7	-1.3	-1.4	-2.1	-1.4	-2.2	-1.6	-1.2	-1.5	-1.7	-1.8
Ever had hysterectomy (womb removed)	2.2	2.5	5.6	-1.7	-1.5	-1.6	-2.1	-1.9	1.5	-1.2	-1.2	-1.2	-1.3	-2.4	-1.2	-2.0	-0.2	-1.1	-1.7	-1.2	-1.9
Pain all over the body in last month	2.2	2.4	4.2	-1.3	-1.6	-1.7	-1.1	-0.8	1.2	-1.7	-1.7	-1.7	-1.8	-1.9	-1.6	-1.6	-1.3	-1.3	-2.0	-1.8	-1.4
Medication: Ventolin 100micrograms inhaler	2.2	2.9	9.8	1.3	1.7	0.7	-0.5	-1.0	-0.7	2.1	2.0	1.0	1.3	1.3	1.8	0.5	3.1	2.8	2.0	1.9	1.7
Financial situation satisfaction	2.2	2.7	5.6	-2.4	-2.1	-1.9	-1.4	-0.8	1.8	-0.9	-0.8	-2.3	-2.1	-1.4	-2.0	-2.2	-1.6	0.0	-1.3	-1.0	-1.4
Medication: Ramipril	2.1	2.7	5.6	-2.4	-1.7	-1.7	-1.4	-1.1	1.8	-1.3	-1.6	-1.6	-1.6	-2.2	-1.8	-1.8	-0.8	-1.3	-1.5	-1.4	-2.0
Exposure to tobacco smoke at home	2.1	2.3	4.3	-2.1	-1.9	-1.5	-0.6	-0.5	1.0	-1.5	-1.5	-1.5	-1.6	-1.9	-1.5	-2.0	-1.4	-1.0	-1.8	-1.6	-1.5
Age at first live birth	2.1	3.8	7.9	2.6	2.5	2.1	1.7	0.6	-2.7	0.6	0.9	2.8	2.5	1.9	2.4	2.4	1.7	0.9	1.9	0.7	1.7
Overall health rating	2.1	4.5	7.4	-2.0	-2.5	-2.4	-1.0	-1.2	1.7	-2.1	-2.0	-2.5	-2.5	-2.7	-2.3	-2.1	-2.1	-1.6	-2.5	-2.1	-1.8
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	3.6	1.5	1.7	1.8	1.6	1.1	-1.4	1.6	1.5	1.7	1.8	1.4	1.6	1.8	1.6	1.0	1.9	1.6	1.5
Wheeze or whistling in the chest in last year	2.0	3.5	6.6	2.3	2.3	1.5	0.8	0.0	-1.3	2.4	2.0	1.8	1.9	1.4	2.2	1.3	2.6	1.9	1.7	2.2	2.2
Medication: Paracetamol	2.0	3.1	5.4	-2.3	-2.3	-1.6	-0.8	0.2	1.4	-1.4	-1.7	-1.9	-2.0	-2.0	-1.9	-2.2	-2.0	-1.7	-1.8	-1.5	-1.5
Alcohol drinker status: Never	2.0	2.5	4.8	1.5	1.6	1.7	1.6	2.0	-0.9	1.8	1.9	1.0	1.2	1.8	1.1	2.2	-0.1	0.9	1.7	1.9	1.7
Average weekly spirits intake	1.9	2.4	4.2	-1.2	-1.4	-1.6	-1.0	-0.9	1.6	-1.6	-1.4	-1.8	-1.8	-2.0	-1.5	-1.6	-1.6	-1.4	-1.7	-1.5	-1.3
Number of incorrect matches in round	1.9	3.1	5.3	-1.5	-1.4	-2.3	-2.1	-1.8	1.8	-1.4	-1.5	-2.1	-2.1	-1.9	-1.6	-2.3	-1.9	-0.7	-1.8	-1.5	-1.4
Heart attack	1.9	2.4	3.6	-1.7	-1.5	-1.6	-1.4	-1.0	1.6	-1.7	-1.9	-1.4	-1.6	-1.8	-1.7	-1.1	-1.1	-1.8	-1.3	-1.7	-1.9
Commuting to job workplace: Car/motor vehicle	1.9	2.1	6.1	0.6	1.3	1.3	0.2	0.8	-0.7	1.9	1.9	1.1	1.4	1.4	1.3	1.0	2.5	1.8	1.7	1.9	1.6
Medication: Atorvastatin	1.9	2.3	3.9	-1.6	-1.9	-1.7	-0.9	-1.0	1.0	-1.7	-1.7	-1.6	-1.8	-2.0	-1.6	-1.6	-1.4	-1.2	-1.3	-1.7	-1.3
HDL Cholesterol	1.8	3.0	7.7	2.2	1.5	1.3	1.1	0.5	-1.5	1.4	1.9	1.3	1.4	2.1	1.6	1.6	2.0	2.8	2.1	1.4	2.0
Eye problems/disorders: Glaucoma	1.8	2.1	3.1	-1.5	-1.6	-1.6	-0.6	-1.0	0.6	-1.7	-1.5	-1.6	-1.7	-1.7	-1.6	-1.7	-1.5	-0.4	-1.8	-1.7	-1.5
Ulcerative Colitis	1.7	2.4	7.5	-0.7	-1.1	-1.9	-2.3	-2.7	1.3	-2.0	-1.3	-1.0	-1.3	-1.6	-1.0	-1.9	-0.6	-0.0	-1.4	-1.9	-1.7
Systolic Blood Pressure	1.7	8.5	24.4	-2.6	-2.7	-2.3	-1.4	-0.9	2.8	-2.4	-3.6	-2.3	-2.4	-3.5	-2.8	-1.6	-4.3	-4.9	-3.4	-2.6	-3.2
Ever used hormone-replacement therapy (HRT)	1.7	2.1	4.5	1.2	0.7	1.1	1.3	1.4	-0.5	1.9	2.0	0.3	0.7	1.2	0.9	1.0	2.1	2.0	1.8	1.9	2.0
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.0	1.2	1.3	1.6	1.7	1.0	-1.6	1.0	1.0	1.7	1.7	1.1	1.7	1.0	1.5	0.7	1.5	1.0	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	4.6	-1.0	-1.8	-2.0	-1.3	-1.4	1.7	-1.5	-1.4	-2.0	-2.0	-1.9	-1.7	-1.9	-1.9	-0.9	-2.1	-1.5	-1.4
Glaucoma (self-reported)	1.7	2.0	3.8	-1.4	-1.0	-1.5	-1.1	-1.5	0.6	-1.8	-1.5	-1.2	-1.4	-1.7	-1.3	-1.7	-0.7	-0.6	-2.0	-1.7	-1.7
Alzheimer’s Disease (in mother)	1.6	1.9	5.2	1.9	1.6	1.5	1.8	0.6	-2.3	0.1	-0.1	2.2	1.9	1.2	1.7	1.7	0.4	-0.6	0.1	0.0	0.7
Crohns Disease (2012)	1.6	2.5	7.7	-1.5	-1.9	-2.0	-1.2	-1.6	0.9	-1.4	-0.8	-2.0	-2.0	-1.8	-1.5	-2.8	-0.7	0.6	-1.6	-1.4	-1.0
Cardiovascular Disease	1.6	5.4	10.3	-2.7	-2.4	-2.1	-1.3	-1.6	1.3	-2.3	-2.8	-1.7	-1.9	-3.0	-2.0	-2.2	-2.7	-3.2	-2.5	-2.4	-2.5
Lung FVC	1.6	8.2	19.6	-2.5	-2.1	-2.3	-1.8	-0.7	1.2	-3.8	-4.4	-1.6	-2.2	-2.6	-2.6	-1.5	-3.6	-4.4	-3.1	-4.0	-3.3
Maternal smoking around birth	1.6	2.3	5.6	-1.6	-1.6	-1.2	-0.1	-0.1	1.2	-1.1	-1.7	-1.4	-1.4	-2.4	-1.5	-1.7	-1.4	-2.3	-1.9	-1.3	-1.6
Sitting height	1.6	11.7	50.4	2.3	2.9	2.1	0.4	-0.1	-0.4	4.3	5.9	1.4	2.2	3.3	2.9	0.4	4.0	7.1	3.6	4.8	3.1
Hair/balding pattern: Pattern 3	1.6	2.4	5.6	1.8	1.8	1.4	0.4	0.1	-1.1	1.4	1.4	1.7	1.8	1.8	1.9	1.6	2.4	1.2	1.7	1.4	1.5
Age at last live birth	1.6	2.4	4.9	2.1	2.1	1.4	0.7	-0.2	-2.0	0.5	0.8	2.2	1.9	1.5	2.0	1.9	1.8	0.8	1.6	0.6	1.3
Ever taken oral contraceptive pill	1.6	1.8	3.9	-1.7	-1.4	-1.5	-1.3	-1.2	1.8	-0.7	-0.5	-1.7	-1.5	-2.0	-1.3	-1.9	-0.3	-0.1	-1.3	-0.6	-1.4
Fasting Glucose	1.5	1.8	3.8	1.1	1.5	1.5	1.7	1.9	-1.1	1.8	1.6	0.8	1.0	1.6	1.3	1.6	-0.0	-0.0	0.6	1.9	0.8
Hearing difficulty/problems: Yes	1.5	2.3	6.0	1.6	2.0	1.1	0.4	-0.2	-1.6	1.2	1.6	1.4	1.4	1.4	1.8	0.4	2.5	2.4	1.5	1.2	1.6
Angina	1.5	1.9	5.3	-1.7	-1.1	-1.4	-1.1	-1.3	0.9	-1.1	-1.5	-1.2	-1.3	-2.3	-1.0	-1.9	-0.7	-1.2	-1.8	-1.2	-1.3
Illnesses of siblings	1.5	2.1	4.1	1.5	1.1	1.5	1.6	1.2	-1.1	1.5	1.8	1.1	1.3	2.0	1.2	1.4	1.2	1.5	1.8	1.6	1.7
Pulse wave reflection index	1.5	1.8	3.2	1.8	1.8	1.6	0.4	0.4	-0.6	1.3	1.5	1.7	1.7	1.6	1.8	1.6	0.9	0.4	1.2	1.5	0.9
Headache pain in last month	1.5	2.6	4.1	-1.4	-1.5	-1.8	-1.2	-1.3	1.3	-1.5	-1.7	-1.7	-1.7	-1.8	-1.5	-2.0	-1.7	-1.4	-2.0	-1.6	-1.8
Leg pain on walking	1.5	1.9	4.2	-1.6	-1.5	-1.5	-0.5	-1.1	0.7	-1.3	-1.4	-1.3	-1.4	-2.0	-1.2	-2.0	-0.9	-0.6	-1.7	-1.4	-1.1
Friendships satisfaction	1.5	1.9	4.3	0.4	0.6	1.3	1.2	1.5	-0.4	2.0	2.0	0.4	0.9	1.4	0.7	0.7	1.5	2.1	1.6	2.0	1.6
Irritable Bowel Disease (IBD)	1.4	3.3	5.4	-0.6	-1.7	-2.3	-1.8	-2.1	1.7	-2.0	-1.6	-2.0	-2.1	-2.2	-1.7	-1.8	-1.8	-0.7	-2.0	-1.9	-1.6
Alcohol usually taken with meals	1.4	2.3	6.1	1.2	1.3	1.8	2.0	2.5	-0.7	1.8	1.8	0.9	1.3	1.9	1.0	1.9	0.2	0.8	1.1	1.9	1.4
Father’s age at death	1.4	1.9	3.8	1.9	1.9	1.2	0.4	0.5	-1.0	1.1	1.2	1.3	1.4	1.5	1.6	1.9	1.3	0.7	1.9	1.2	1.5
Worry too long after embarrassment	1.4	2.3	5.1	2.3	1.5	1.3	0.5	0.2	-1.1	1.8	1.8	1.4	1.5	1.6	1.8	1.4	1.8	1.2	1.2	1.8	1.6
Had major operations	1.4	1.7	3.7	-1.3	-1.5	-1.6	-1.9	-1.0	1.7	-1.2	-0.8	-1.5	-1.5	-1.5	-1.4	-1.8	0.0	0.0	-0.5	-1.1	-1.0
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	6.2	1.7	1.4	1.1	0.8	0.4	-1.3	0.8	0.9	1.4	1.3	1.2	1.5	0.8	2.5	1.8	1.3	0.8	1.1
Fractured/broken bones in last 5 years	1.4	1.8	3.7	-1.4	-1.7	-1.2	0.6	-0.3	0.1	-1.4	-1.7	-1.4	-1.4	-1.4	-1.4	-1.1	-1.9	-1.4	-1.3	-1.6	-0.9
Type 2 Diabetes (T2D) (2018)	1.3	2.4	3.6	-1.3	-1.3	-1.5	-1.4	-1.5	1.6	-1.6	-1.7	-1.1	-1.2	-1.8	-1.3	-1.5	-1.9	-1.8	-1.8	-1.6	-1.8
High blood pressure	1.3	3.7	10.1	-2.3	-2.1	-1.4	-0.1	-0.4	0.6	-2.2	-2.8	-1.1	-1.4	-2.6	-1.7	-1.5	-2.1	-3.2	-1.8	-2.3	-2.2
Medication: Atenolol	1.3	1.6	2.6	-1.5	-1.2	-1.3	-1.3	-0.7	1.4	-1.1	-1.2	-1.3	-1.4	-1.6	-1.4	-0.6	-1.6	-1.1	-1.0	-1.1	-1.2
Illnesses of father: High blood pressure	1.3	1.6	3.8	-0.7	-1.1	-1.2	-0.2	-0.4	0.8	-1.6	-1.7	-1.2	-1.4	-1.2	-1.2	-0.8	-2.0	-1.8	-1.4	-1.6	-1.3
Alzheimer’s Disease (including proxy)	1.2	1.8	4.8	2.2	1.9	1.4	1.5	0.5	-2.0	0.8	0.4	1.8	1.6	1.2	1.6	1.6	0.3	-0.2	-0.0	0.5	1.1
Ulcerative Colitis (UC)	1.2	2.2	3.6	-0.4	-1.0	-1.6	-1.9	-1.5	1.7	-1.9	-1.7	-1.2	-1.4	-1.8	-1.3	-0.7	-1.8	-1.4	-1.3	-1.8	-1.6
Smoking Status	1.2	2.9	15.3	-0.9	-0.9	-1.8	-2.3	-3.9	0.7	0.0	0.8	-1.1	-0.9	-1.1	-0.1	-3.1	1.4	3.1	-0.4	0.1	-0.5
Multivitamins +/- minerals	1.2	1.5	2.3	-0.7	-1.0	-1.3	-1.5	-1.4	1.2	-1.5	-1.4	-0.9	-1.1	-0.9	-1.2	-0.5	-1.2	-1.4	-1.1	-1.5	-1.5
Noisy workplace	1.2	1.5	5.0	-0.5	-0.6	-1.4	-2.2	-2.0	1.8	-1.2	-0.8	-0.9	-1.0	-1.0	-0.8	-1.1	-0.5	0.1	-1.3	-1.1	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.6	-1.1	-1.9	-1.3	-0.3	-0.4	0.6	-1.2	-1.3	-1.4	-1.5	-1.5	-1.6	-1.1	-1.8	-1.3	-1.9	-1.3	-0.9
Medication: Aspirin	1.2	1.6	2.5	-1.5	-1.5	-1.3	-1.1	-0.2	1.4	-1.1	-1.4	-1.4	-1.5	-1.6	-1.4	-1.0	-0.5	-1.4	-1.2	-1.1	-1.2
Vascular/heart problems diagnosed by doctor	1.2	3.4	9.1	2.3	2.0	1.3	0.3	0.5	-0.6	1.8	2.6	1.0	1.3	2.5	1.6	1.6	2.0	3.0	1.7	2.0	2.0
Rheumatoid Arthritis	1.1	1.5	2.7	1.2	0.8	1.4	1.2	1.4	-0.6	1.5	1.6	0.9	1.1	1.3	1.0	1.3	0.8	0.7	1.5	1.6	1.7
Medication: Co-codamol	1.1	1.3	3.4	0.8	0.5	0.8	1.1	0.7	-1.4	1.3	1.5	0.6	0.7	1.2	1.0	0.4	1.1	1.8	1.2	1.3	1.8
Taking other prescription medications	1.1	1.6	4.0	-0.9	-0.7	-1.7	-1.7	-1.7	1.2	-0.8	-1.1	-1.4	-1.4	-2.0	-1.0	-1.4	-0.2	-1.0	-1.5	-0.9	-1.1
Medication: Cholesterol lowering	1.1	1.8	3.5	-1.7	-1.4	-1.2	-1.1	-0.1	1.9	-0.5	-0.9	-1.5	-1.4	-1.7	-1.4	-1.4	-1.3	-1.8	-1.4	-0.6	-1.1
Pulse wave Arterial Stiffness index	1.1	1.3	2.5	1.3	1.3	1.1	0.4	-0.2	-0.8	1.2	1.3	1.4	1.5	1.3	1.6	0.7	1.2	0.8	0.9	1.3	0.8
Emphysema/chronic bronchitis	1.1	1.2	8.2	-0.3	-0.0	-1.0	-1.9	-2.9	0.5	-0.4	-0.1	-0.0	-0.1	-0.8	0.2	-1.7	1.4	1.2	-0.7	-0.4	-0.5
Medication: Ibuprofen	1.1	1.3	3.4	-1.9	-1.4	-1.3	-1.0	-0.6	1.0	-0.7	-0.6	-1.6	-1.5	-1.2	-1.2	-1.6	-0.8	-0.2	-0.7	-0.8	-0.7
Bipolar Disorder (2018)	1.0	1.5	5.4	-1.0	-0.6	-1.3	-2.3	-2.3	0.9	-1.3	-0.9	-0.5	-0.7	-1.0	-0.6	-1.6	-0.1	-0.5	-1.2	-1.1	-1.6
Verbal and Numeric Reasoning (VNR)	1.0	2.4	5.7	1.3	1.2	1.9	1.3	0.7	-1.8	1.0	1.1	2.4	2.3	1.5	2.0	1.0	2.4	0.8	1.3	1.1	1.3
Age at First Birth	1.0	1.5	4.8	1.0	1.0	1.4	2.2	2.1	-1.9	0.6	0.6	1.2	1.1	1.3	0.9	1.6	-0.1	0.0	0.8	0.6	1.2
Allergy or Eczema	1.0	2.5	3.9	1.6	2.0	1.9	1.9	1.0	-1.9	1.6	1.5	1.8	1.8	1.8	1.8	1.3	0.1	0.9	1.0	1.6	1.8
Current tobacco smoking	1.0	1.7	5.0	-1.1	-1.1	-1.7	-1.8	-2.2	1.4	-0.8	-0.4	-1.4	-1.4	-1.3	-0.9	-2.1	-0.3	0.6	-0.9	-0.7	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.4	0.5	0.4	1.0	1.5	1.2	-1.0	1.7	1.7	0.4	0.7	1.1	0.7	0.2	0.1	1.6	0.7	1.7	1.9
Hearing difficulty/problems with background noise	1.0	1.6	8.1	1.4	1.7	0.5	-0.2	-0.7	-1.2	0.5	1.0	1.0	0.9	0.9	1.5	0.1	2.8	2.0	1.1	0.6	1.0
Had menopause	1.0	1.3	3.9	-2.0	-1.2	-0.7	-0.1	0.6	0.8	-0.7	-1.2	-1.0	-1.0	-1.5	-1.3	-1.1	-1.4	-1.6	-0.7	-0.9	-0.9
Diabetes diagnosed by doctor	1.0	1.7	3.1	-0.7	-1.1	-1.3	-1.2	-1.3	1.1	-1.5	-1.8	-0.7	-0.9	-1.5	-1.0	-1.1	-1.2	-1.7	-1.3	-1.6	-1.5
Number of self-reported non-cancer illnesses	1.0	1.7	4.5	-1.0	-0.5	-1.2	-1.2	-1.8	0.2	-1.5	-1.7	-0.3	-0.7	-2.1	-0.3	-1.8	-0.4	-1.5	-1.7	-1.6	-1.3
Irritability	1.0	1.8	7.3	-0.6	-0.9	-1.8	-0.9	-2.3	0.2	-1.4	-0.7	-1.3	-1.3	-1.3	-0.7	-2.7	0.8	1.6	-1.1	-1.3	-0.8
Bipolar Disorder or Schizophrenia	0.9	2.2	4.2	-1.3	-1.3	-1.5	-2.0	-1.7	1.4	-1.6	-1.5	-1.0	-1.2	-1.6	-1.2	-1.1	-1.7	-1.6	-1.2	-1.5	-1.8
Breast Cancer	0.9	2.3	4.8	1.2	0.8	1.4	1.5	1.0	-0.9	1.8	1.8	1.1	1.4	1.3	1.2	1.2	1.7	2.2	2.2	1.7	1.8
Vitamin and mineral supplements	0.9	1.2	2.0	0.6	0.8	1.3	1.4	1.3	-1.0	1.4	1.3	0.8	0.9	0.9	0.8	0.5	0.9	1.4	1.0	1.4	1.2
Severe depression (siblings)	0.9	1.0	2.9	-1.1	-0.8	-0.9	-0.4	-1.1	-0.0	-1.3	-0.9	-0.5	-0.8	-1.7	-0.7	-1.6	-0.1	0.0	-1.4	-1.2	-1.2
Fed-up feelings	0.9	1.7	6.7	-0.5	-1.1	-1.7	-1.2	-2.3	0.7	-0.9	-0.5	-1.2	-1.1	-1.4	-0.7	-2.6	0.1	1.4	-1.6	-0.9	-0.8
Supplements: Glucosamine	0.9	1.2	2.1	-0.7	-1.3	-1.1	-0.9	-1.2	0.5	-1.4	-1.4	-0.6	-0.8	-1.1	-0.8	-0.9	-0.6	-1.3	-1.2	-1.4	-1.2
Medication: Simvastatin	0.9	1.3	3.6	-1.5	-1.2	-0.9	-0.7	-0.2	1.1	-0.6	-1.0	-0.9	-0.8	-1.6	-0.9	-1.3	-1.4	-1.9	-1.6	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	6.7	-1.5	-1.5	-1.5	-1.8	-0.1	2.6	-1.8	-1.7	-1.7	-1.9	-1.0	-2.1	-0.6	-2.1	-1.9	-1.5	-1.7	-2.3
Medication: Lansoprazole	0.9	1.0	2.9	0.9	0.7	0.7	0.9	0.5	-0.8	1.3	1.3	0.5	0.7	1.0	0.9	0.3	1.7	1.2	0.5	1.2	1.4
Angina (self-reported)	0.9	1.2	3.8	-1.3	-0.7	-1.2	-0.9	-1.3	0.6	-0.8	-1.1	-0.9	-1.1	-1.9	-0.7	-1.6	-0.4	-0.7	-1.5	-0.9	-1.0
Pulse rate, automated reading	0.9	2.9	8.8	-1.9	-3.0	-1.8	-0.3	-0.1	1.6	-1.2	-1.1	-2.5	-2.3	-1.6	-2.5	-1.7	-2.1	-0.5	-1.2	-1.2	-0.8
Chest pain or discomfort	0.9	1.3	3.1	0.8	1.7	1.2	0.4	-0.3	-1.6	1.1	1.0	1.8	1.6	0.3	1.7	0.6	1.3	0.7	0.6	1.1	0.9
Hypertension (Self-reported)	0.9	2.6	7.2	-2.0	-1.9	-1.0	0.6	0.1	0.1	-1.8	-2.4	-0.8	-1.1	-2.1	-1.4	-1.2	-1.8	-2.7	-1.4	-2.0	-1.7
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	8.6	0.4	0.2	-1.4	-1.5	-2.9	-0.2	-1.8	-1.4	-0.3	-0.7	-1.2	0.0	-1.3	0.5	-0.0	-0.9	-1.8	-1.0
Average weekly champagne plus white wine intake	0.9	1.2	3.1	1.7	1.6	1.2	1.3	0.2	-1.6	0.2	0.0	1.8	1.6	0.8	1.5	1.3	0.6	-0.5	0.4	0.2	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.1	-1.5	-1.0	-1.2	-0.9	-0.6	0.9	-0.9	-0.9	-1.3	-1.3	-1.3	-1.0	-1.3	-0.6	-0.6	-0.8	-1.0	-0.9
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.7	-0.9	-0.9	-0.9	-0.4	-0.6	0.4	-1.0	-1.3	-0.7	-0.9	-1.6	-0.7	-1.4	-0.5	-1.1	-1.0	-1.1	-0.8
Shortness of breath walking on level ground	0.8	0.9	3.7	-0.7	-0.9	-1.0	-0.5	0.4	1.5	0.2	-0.3	-1.9	-1.6	-1.0	-1.5	-0.7	-0.7	-0.5	-1.0	0.0	-0.1
Neck or shoulder pain in last month	0.8	1.2	2.7	-0.9	-0.8	-1.4	-1.6	-1.2	1.3	-0.9	-0.9	-1.2	-1.2	-1.3	-1.0	-1.3	-0.3	-0.2	-1.1	-0.9	-0.8
Mean time to correctly identify matches	0.8	1.5	2.4	1.3	1.3	1.5	0.8	1.4	-0.9	1.6	1.3	1.2	1.3	1.4	1.4	1.3	1.1	-0.1	0.4	1.6	1.4
Family relationship satisfaction	0.8	1.0	2.8	0.5	0.2	0.7	0.6	0.8	-0.3	1.5	1.6	0.3	0.6	1.1	0.6	0.3	0.8	1.7	1.2	1.5	1.2
Medication: Aspirin	0.8	1.1	1.9	-1.0	-1.4	-1.1	-0.8	-0.1	1.1	-0.8	-1.1	-1.2	-1.2	-1.2	-1.2	-0.8	-0.9	-1.2	-1.0	-0.9	-0.9
Commuting to job workplace: Public transport	0.8	0.9	5.3	-0.1	-0.4	0.4	1.1	1.5	-0.3	-0.8	-1.2	0.2	-0.0	-0.4	-0.4	0.8	-1.6	-2.3	-0.3	-0.9	-0.5
Cholesterol lowering medication	0.8	1.1	1.8	-1.1	-1.0	-1.1	-0.6	-0.6	0.9	-1.0	-1.1	-1.1	-1.1	-1.3	-1.0	-0.9	-1.3	-1.2	-1.3	-1.1	-0.9
Lung FEV1/FVC ratio	0.7	3.5	15.4	-1.7	-1.8	-1.1	-1.9	1.0	3.9	-0.6	-0.8	-2.2	-1.9	-1.0	-2.5	0.3	-2.7	-2.4	-1.3	-0.4	-2.0
Systolic blood pressure, automated reading	0.7	2.0	11.0	-1.3	-1.1	-0.7	-0.8	0.1	1.7	-0.6	-1.8	-0.7	-0.7	-2.0	-1.2	-0.3	-1.9	-3.3	-1.3	-0.9	-1.4
Age when periods started (menarche)	0.7	1.8	4.8	-1.6	-1.3	-1.2	-1.6	-0.1	2.2	-0.7	-0.6	-1.7	-1.6	-1.4	-1.7	-1.1	-1.4	-1.4	-1.0	-0.6	-1.2
Hayfever, allergic rhinitis or eczema	0.7	1.6	2.9	1.1	1.7	1.5	1.4	0.8	-1.3	1.4	1.3	1.5	1.5	1.2	1.5	1.0	-0.2	0.7	0.8	1.4	1.3
Past tobacco smoking	0.7	1.3	6.0	0.7	0.3	1.0	1.4	2.4	0.1	0.2	-0.2	0.2	0.2	0.7	-0.2	2.0	-2.0	-2.1	0.2	0.2	0.4
Qualifications: None of the above	0.7	1.5	3.7	-1.4	-1.1	-1.6	-1.4	-1.4	1.3	-0.6	-0.6	-1.6	-1.5	-1.6	-1.2	-1.9	-0.6	0.1	-0.8	-0.7	-0.8
Diabetes (self-reported)	0.7	1.1	2.1	-0.6	-0.6	-1.1	-1.5	-1.3	1.3	-0.9	-1.2	-0.6	-0.6	-1.2	-0.7	-1.0	-1.0	-1.3	-1.0	-1.0	-1.2
Fluid intelligence score	0.7	1.5	4.2	0.7	0.9	1.6	1.1	0.9	-1.3	0.8	0.9	1.9	1.8	1.1	1.4	0.9	2.1	0.7	1.3	0.8	0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.9	0.9	1.2	1.7	1.5	1.2	-0.9	1.1	1.4	1.5	1.6	1.6	1.4	1.0	0.5	1.0	0.7	1.3	0.9
Tense / ‘highly strung’	0.7	1.1	3.2	1.7	1.0	0.9	0.9	-0.1	-1.8	0.5	0.7	1.3	1.1	1.0	1.2	0.5	0.7	1.5	0.9	0.5	1.2
Peak expiratory flow (PEF)	0.7	1.5	2.9	-1.1	-0.9	-1.0	-1.3	-0.5	1.7	-1.3	-1.2	-1.1	-1.2	-1.2	-1.5	0.0	-1.7	-1.1	-1.2	-1.2	-1.6
Comparative body size at age 10	0.7	1.9	5.7	0.5	1.2	1.9	2.4	2.1	-1.9	1.2	0.7	1.6	1.6	0.5	1.2	1.1	1.2	-0.5	1.0	1.1	1.1
Illnesses of siblings: Diabetes	0.7	0.9	2.8	-0.9	-0.5	-0.6	-0.7	-0.6	-0.2	-1.4	-1.7	0.2	-0.2	-1.1	-0.5	-0.7	-0.9	-1.3	-0.9	-1.5	-1.3
Commuting to job workplace: Walk	0.7	0.7	4.2	0.2	-0.4	-0.3	0.5	0.6	0.4	-0.8	-1.1	-0.5	-0.7	-0.2	-0.6	0.6	-1.7	-2.0	-0.7	-0.8	-0.4
Smoking status: Current	0.7	1.0	3.5	-0.7	-0.8	-1.4	-1.5	-1.9	1.1	-0.5	-0.1	-1.2	-1.1	-0.8	-0.6	-1.8	-0.2	0.7	-0.5	-0.4	-0.8
Diastolic blood pressure, automated reading	0.7	2.3	14.3	-1.1	-1.1	-0.3	0.3	1.2	1.4	-0.6	-1.7	-0.7	-0.7	-1.8	-1.2	0.1	-2.7	-3.8	-1.7	-0.8	-1.2
Schizophrenia (2018)	0.6	1.2	4.4	-0.8	-1.1	-0.9	-0.8	-0.4	1.1	-1.0	-1.3	-0.9	-1.0	-1.2	-1.1	-0.2	-2.1	-1.6	-0.6	-1.1	-1.0
Crohns Disease (2017)	0.6	1.4	3.2	-0.1	-1.2	-1.7	-0.8	-1.2	1.1	-0.8	-0.3	-1.8	-1.7	-1.4	-1.2	-1.6	-0.6	0.6	-1.5	-0.8	-0.4
Relative age voice broke	0.6	1.0	4.5	0.0	-0.7	-1.1	-1.2	0.4	2.1	0.3	-0.1	-2.0	-1.6	0.1	-1.3	-0.1	-1.1	0.0	-0.5	0.1	0.3
Forced vital capacity (FVC)	0.6	2.1	4.0	-1.3	-1.1	-1.4	-1.6	-0.5	1.8	-1.9	-1.6	-1.3	-1.6	-1.0	-1.6	-0.9	-1.4	-1.3	-1.4	-1.8	-2.0
Allergy	0.6	1.4	2.6	-0.9	-1.5	-1.0	-1.1	-0.1	1.2	-1.6	-1.6	-1.0	-1.2	-0.9	-1.4	-0.2	-0.9	-1.6	-0.8	-1.6	-1.6
Falls in the last year	0.6	0.9	5.3	-0.5	-0.2	0.3	1.4	1.3	-0.9	-0.8	-1.1	0.0	-0.2	-0.4	-0.1	0.3	-1.2	-2.3	-1.1	-0.8	0.1
Mouth/teeth dental problems: Dentures	0.6	1.0	2.4	0.3	1.0	0.7	0.5	-0.2	-0.6	1.5	1.3	0.8	1.0	0.1	1.3	-0.7	1.5	1.5	0.6	1.4	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.7	-0.9	-1.2	-1.0	-1.3	0.4	1.9	-1.4	-1.4	-1.3	-1.5	-0.5	-1.6	-0.2	-1.8	-1.8	-1.4	-1.3	-1.7
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.6	0.7	1.1	0.5	0.4	-0.1	-0.7	1.0	1.2	0.6	0.7	0.4	1.1	-0.5	0.9	1.6	0.4	1.0	1.0
Smoking status: Previous	0.6	0.9	4.8	-0.4	-0.1	-0.7	-1.1	-2.2	-0.3	-0.1	0.1	0.1	0.1	-0.7	0.4	-1.4	2.0	1.6	-0.3	-0.2	-0.3
Average weekly red wine intake	0.6	0.9	2.1	-1.1	-0.8	-0.4	0.1	0.9	1.0	-0.7	-0.9	-0.8	-0.8	-1.2	-1.1	-0.5	-0.9	-1.5	-1.5	-0.7	-0.9
Loneliness, isolation	0.6	0.8	4.6	0.6	0.3	0.4	0.5	0.3	-0.1	1.0	1.5	0.1	0.3	0.7	0.6	-0.2	1.0	2.2	1.0	1.1	1.1
Back pain experienced in last month	0.6	0.9	3.0	0.2	-0.5	-1.3	-1.7	-1.7	1.2	-0.1	0.3	-1.1	-1.0	-0.3	-0.6	-1.0	0.6	1.6	0.2	-0.1	-0.3
Mother’s age at death	0.6	0.7	2.2	0.7	0.9	0.4	-0.6	-0.6	-0.7	0.6	0.7	0.9	0.8	0.9	0.8	0.7	1.5	1.2	1.3	0.5	0.5
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.7	-0.6	-0.7	-1.0	-1.2	-1.3	0.5	-1.1	-1.2	-0.4	-0.6	-0.4	-0.6	-0.7	-0.8	-0.5	-0.7	-1.2	-0.9
LDL Cholesterol	0.5	0.7	2.7	-0.6	-0.6	-1.1	-1.6	-0.7	1.7	-0.1	0.2	-1.4	-1.3	-0.6	-1.0	-0.3	-0.2	0.3	-0.1	0.1	-0.6
Heel T-Score	0.5	4.3	14.1	3.0	2.0	0.7	-0.3	-1.2	-1.2	1.8	2.3	1.2	1.4	3.3	2.1	1.3	2.8	3.8	1.8	1.8	1.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.4	-0.3	0.3	-0.4	-0.5	-1.5	-1.0	-1.2	-1.1	0.7	0.3	-1.0	0.5	-0.8	0.7	-0.7	-0.7	-1.2	-0.7
Medication for hormone replacement therapy	0.5	0.5	1.7	0.2	-0.7	-1.0	-0.6	-0.1	1.3	-0.3	-0.7	-1.3	-1.2	-0.2	-1.0	-0.2	-0.7	-0.6	-0.6	-0.5	-0.2
Diabetes (father)	0.5	0.6	1.2	-0.5	-0.5	-0.7	-1.1	-0.7	1.0	-0.7	-0.8	-0.4	-0.5	-0.9	-0.6	-0.9	-0.8	-0.9	-0.8	-0.7	-1.0
Medication: Levothyroxine sodium	0.5	0.8	1.7	-0.6	-0.4	-1.1	-1.2	-1.2	0.6	-0.7	-0.9	-0.8	-0.9	-1.1	-0.7	-0.7	-0.8	-0.6	-1.3	-0.8	-1.0
Alcohol intake versus 10 years previously	0.5	0.8	4.7	-0.8	-0.3	-0.2	0.0	0.3	-0.3	-0.8	-1.6	0.1	-0.3	-0.8	-0.3	0.0	-1.3	-2.2	-0.7	-1.1	-0.9
Depression (self-reported)	0.5	0.6	1.5	-0.1	-0.9	-0.7	-0.4	-0.9	-0.3	-1.1	-1.1	-0.2	-0.4	-0.7	-0.7	-0.5	-1.2	-0.9	-0.9	-1.1	-0.7
Prospective memory result	0.5	0.7	3.6	-0.1	0.0	0.4	0.7	1.9	0.6	1.0	0.4	-0.6	-0.3	0.5	-0.6	1.3	-1.2	-0.6	0.5	0.8	0.7
Hair/balding pattern: Pattern 4	0.5	1.1	2.3	-1.1	-1.0	-1.2	-0.6	-1.2	0.5	-1.3	-1.0	-0.9	-1.0	-1.2	-0.9	-1.5	-1.0	-0.4	-1.2	-1.3	-1.0
High blood pressure (siblings)	0.5	0.8	1.8	-0.9	-0.5	-0.7	-0.9	-0.3	0.9	-0.7	-1.1	-0.6	-0.7	-1.3	-0.9	-0.3	-0.8	-1.4	-1.0	-0.8	-1.2
Pulse wave peak to peak time	0.5	0.6	1.3	-0.9	-0.7	-0.8	-0.2	0.3	0.5	-0.8	-0.8	-1.1	-1.1	-0.9	-1.1	-0.6	-0.6	-0.3	-0.5	-0.9	-0.5
Health satisfaction	0.5	0.7	2.0	-0.8	-1.0	-0.7	-0.4	0.3	1.4	0.3	0.3	-1.3	-1.1	-0.5	-1.0	-1.1	-1.0	0.2	-0.9	0.4	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.6	-1.1	-0.8	-0.6	-0.2	-0.4	0.4	-0.7	-0.6	-0.7	-0.7	-1.3	-0.6	-1.1	-0.4	-0.4	-0.9	-0.7	-0.5
Risk taking	0.5	0.7	2.7	-0.9	-0.9	-0.4	-0.3	0.7	1.6	0.4	0.1	-1.2	-0.9	-0.9	-1.2	0.3	-1.1	-1.1	0.1	0.4	-0.6
Commuting to job workplace: Cycle	0.5	0.7	1.6	0.8	0.5	0.3	0.1	-0.7	-1.1	-1.1	-1.1	1.2	0.7	-0.2	0.5	0.6	-0.8	-1.2	-0.5	-1.1	-0.7
Alcohol drinker status: Previous	0.5	0.6	2.3	-0.0	-0.5	-0.7	-0.7	-0.8	0.5	-0.9	-1.2	-0.3	-0.5	-0.7	-0.5	-0.3	-1.0	-1.5	-0.9	-0.9	-0.6
Depression (Nagel 2018)	0.4	0.6	2.2	-0.2	-0.2	0.3	0.1	0.5	0.1	1.4	1.5	-0.2	0.1	0.8	0.1	-0.4	-0.2	1.5	0.6	1.4	1.2
Schizophrenia vs Biploar Disorder	0.4	0.5	2.1	-0.7	-0.9	0.0	0.7	1.4	0.4	0.3	0.7	-0.9	-0.7	0.2	-0.8	0.2	-0.7	0.6	0.6	0.4	0.5
Bipolar Disorder (2011)	0.4	0.4	1.7	0.0	0.8	0.2	-0.6	-0.9	-0.1	0.4	0.9	0.6	0.6	0.8	0.0	0.2	1.3	0.9	0.4	0.6	0.5
Body Mass Index (BMI) (2010)	0.4	0.6	1.3	-1.0	-0.9	-0.6	-0.4	-0.3	0.9	0.1	-0.1	-1.0	-0.8	-1.1	-0.8	-0.7	-1.2	-0.6	-0.7	0.1	-0.6
Hand grip strength (left)	0.4	1.1	2.4	-1.0	-0.7	-1.0	-0.7	-0.7	1.1	-1.2	-1.4	-0.8	-1.0	-1.1	-1.0	-0.6	-1.1	-1.3	-1.1	-1.3	-1.5
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.4	-0.8	-1.2	-0.7	-0.4	-0.0	1.1	0.4	0.4	-1.2	-0.9	-0.2	-1.0	-0.8	-1.5	0.3	-0.5	0.3	0.1
Diabetes (mother)	0.4	0.5	1.9	-0.7	-0.7	-0.3	-0.4	-0.1	0.7	-0.6	-0.7	-0.2	-0.3	-0.9	-0.6	-0.3	-1.3	-1.4	-1.0	-0.6	-0.8
Chronic bronchitis/emphysema (father)	0.4	0.4	1.5	0.6	1.2	0.8	0.4	0.1	-0.7	0.2	0.1	0.9	0.7	0.3	0.7	0.9	0.8	-0.2	1.0	0.2	0.3
Mouth/teeth dental problems	0.4	0.6	1.7	-0.4	-0.9	-0.1	0.2	1.3	0.6	-0.3	-0.6	-0.7	-0.7	0.3	-1.2	1.1	-1.1	-1.3	0.2	-0.4	-0.3
Hip circumference	0.4	1.9	6.2	0.7	1.0	1.6	1.5	2.0	-0.3	2.5	1.8	0.9	1.3	0.5	1.2	0.6	-0.2	0.5	0.9	2.3	1.6
Standing height	0.4	3.8	15.9	0.3	1.6	1.3	-0.0	0.5	0.4	2.8	3.9	0.5	1.1	1.2	1.5	-0.4	2.1	4.0	1.8	3.2	1.4
Blood clot in the leg (DVT)	0.4	0.5	1.8	-1.4	-0.9	-0.7	-0.4	-0.4	0.5	-0.3	-0.1	-0.9	-0.8	-0.8	-0.6	-1.1	0.6	-0.1	-0.5	-0.3	-0.2
Gout (self-reported)	0.4	0.6	2.7	-1.1	-0.8	-0.3	-0.5	-0.2	0.2	-0.3	-0.8	-0.1	-0.2	-1.0	-0.5	-0.5	-1.3	-1.6	-0.9	-0.4	-0.9
Forced vital capacity (FVC), Best measure	0.4	1.6	2.5	-1.1	-1.1	-1.1	-1.2	-0.0	1.3	-1.6	-1.4	-1.2	-1.4	-0.9	-1.4	-0.8	-1.4	-1.4	-1.4	-1.5	-1.6
Number of full brothers	0.4	0.5	4.8	-0.0	-0.5	-0.5	-0.1	-0.8	-0.3	0.1	0.7	-0.6	-0.5	0.2	-0.3	-1.0	-0.4	2.2	0.0	0.1	0.5
Mouth/teeth dental problems: Loose teeth	0.4	0.4	2.8	0.5	0.6	-0.2	-1.4	-1.7	0.5	0.2	0.2	0.5	0.5	-0.2	0.6	-0.5	0.7	0.2	-0.4	0.2	-0.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.2	1.1	0.9	0.6	-0.1	-0.1	-0.5	0.3	0.4	0.8	0.8	1.1	0.9	0.8	0.6	0.6	0.9	0.4	0.7
Ever had bowel cancer screening	0.4	0.4	1.7	-0.1	-0.1	-0.4	-0.2	-0.7	-0.1	-0.9	-0.6	0.0	-0.1	-0.9	0.1	-1.1	1.3	0.0	-1.1	-0.8	-0.5
Medication for cholesterol	0.4	0.5	1.5	0.1	0.8	1.0	0.2	0.1	-0.7	0.5	1.0	1.2	1.1	0.4	1.0	0.3	1.0	0.8	0.7	0.7	0.2
Osteoporosis (self-reported)	0.4	0.5	1.6	0.7	1.0	0.5	0.2	-1.0	-1.1	-0.1	-0.2	1.3	1.1	-0.1	1.1	0.4	1.0	-0.1	0.4	-0.2	0.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.7	0.1	0.1	0.4	0.2	0.6	0.3	1.2	1.3	-0.1	0.1	0.8	0.1	0.5	0.5	1.2	1.0	1.2	0.7
Guilty feelings	0.4	0.6	1.6	0.9	0.6	0.4	0.9	0.1	-1.3	0.7	0.9	0.4	0.5	0.8	1.0	-0.3	0.7	1.1	0.4	0.7	1.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.5	0.5	0.7	0.8	0.9	1.2	-0.5	0.6	0.6	0.4	0.4	0.9	0.3	0.9	0.5	0.7	0.5	0.6	0.9
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.4	-0.4	-0.1	-0.1	0.5	0.8	0.2	1.0	1.0	-0.9	-0.6	-0.2	-0.2	-0.5	0.9	1.2	0.5	0.9	0.8
Ever smoked	0.4	0.7	2.9	-0.7	-0.4	-0.8	-1.2	-1.7	0.0	-0.2	0.2	-0.4	-0.4	-0.5	-0.1	-1.5	1.3	1.7	0.1	-0.2	-0.2
Ever depressed for a whole week	0.4	0.5	1.5	0.9	0.9	0.7	1.1	1.2	-0.4	0.9	0.6	0.3	0.3	0.5	0.5	0.5	-0.3	-0.2	-0.4	0.9	0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.9	-1.4	-0.9	-0.8	-0.5	-0.5	0.6	-0.3	-0.1	-1.1	-0.8	-0.8	-0.6	-1.2	0.5	0.0	-0.4	-0.3	-0.3
Depressed Affect (Nagel 2018)	0.3	0.6	3.5	0.3	-0.3	-0.7	-0.9	-1.3	0.3	0.2	0.3	-0.2	-0.2	-0.3	0.1	-1.6	1.1	1.9	-0.3	0.1	0.4
Neuroticism (Nagel 2018)	0.3	0.8	3.7	0.7	0.8	0.3	-0.1	-0.5	-0.8	0.9	0.7	0.6	0.6	0.5	1.0	-0.9	1.6	1.9	0.4	0.7	1.1
Alzheimer’s Disease (in father)	0.3	0.3	1.0	-0.4	-0.3	-0.6	-0.9	-0.6	0.4	-0.3	-0.3	-0.5	-0.5	-0.7	-0.3	-0.7	-0.7	0.0	-1.0	-0.3	-0.5
Ovarian Cancer	0.3	0.4	1.1	0.2	-0.3	-0.7	-0.9	-1.1	0.2	-0.7	-0.7	-0.3	-0.5	-0.7	-0.3	-0.4	-0.9	-0.2	-0.6	-0.8	-0.4
Prostate Cancer	0.3	0.4	1.3	1.0	0.2	0.2	0.7	-0.4	-1.2	-1.0	-0.5	0.8	0.6	0.8	0.6	0.1	0.5	0.1	0.1	-0.8	-0.1
Neuroticism (2016)	0.3	0.4	1.2	-0.4	-0.8	-0.5	-0.1	-0.0	0.9	0.1	0.2	-1.0	-0.8	-0.5	-0.7	-1.0	-1.1	-0.2	-1.0	0.1	-0.2
Schizophrenia (2014)	0.3	0.7	1.6	-0.6	-0.9	-0.9	-0.9	-1.0	0.7	-1.3	-1.0	-0.6	-0.8	-0.9	-0.6	-0.3	-1.0	-0.9	-0.5	-1.1	-1.0
Sensitivity / hurt feelings	0.3	0.6	3.0	0.6	0.6	-0.3	-1.1	-1.5	-0.1	0.4	0.8	0.1	0.1	0.1	0.7	-0.7	1.0	1.7	0.3	0.5	0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.9	-0.8	-0.9	-0.6	-0.5	-0.5	0.7	-0.2	-0.2	-0.6	-0.5	-0.8	-0.7	-0.8	-0.1	0.1	-0.3	-0.2	-0.9
Pack years adult smoking proportion	0.3	0.4	1.9	-0.3	-0.3	-0.9	-0.8	-1.4	0.3	-0.0	0.2	-0.7	-0.6	-0.6	-0.3	-0.9	0.7	0.9	-0.2	-0.0	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	4.4	0.3	0.3	-0.9	-1.6	-2.1	0.2	-0.9	-0.1	0.0	-0.2	0.1	0.4	-0.6	0.9	1.1	0.1	-0.7	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	4.0	-0.2	0.1	-1.0	-2.0	-1.9	0.8	-1.1	-0.4	-0.1	-0.3	-0.1	0.1	-0.5	0.6	0.6	0.3	-1.0	-0.9
Pulse rate	0.3	0.5	2.0	-0.6	-1.4	-0.3	0.7	0.8	0.5	0.2	0.1	-1.0	-0.7	0.1	-1.0	-0.4	-1.3	0.1	-0.4	0.1	0.2
Lung cancer (father)	0.3	0.3	1.1	-0.6	-0.4	-0.6	-0.1	-0.6	-0.2	-0.5	-0.5	-0.6	-0.6	-1.1	-0.3	-0.9	-0.6	-0.4	-0.7	-0.5	-0.4
Breastfed as a baby	0.3	0.3	1.5	0.4	0.1	0.2	0.7	1.2	-0.4	-0.4	-0.7	0.1	-0.1	0.5	-0.3	1.1	-0.7	-0.7	0.5	-0.5	0.2
Birth weight of first child	0.3	0.5	4.4	-0.6	-0.8	0.6	1.5	2.1	-0.3	0.3	0.3	-0.3	-0.3	-0.2	-0.4	0.0	-0.1	-0.4	0.1	0.3	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	2.1	-0.7	-0.1	0.1	0.0	0.7	0.3	-0.4	-0.6	0.1	-0.1	-0.3	-0.5	0.3	-1.5	-1.2	-0.6	-0.3	-0.7
Heart disease (mother)	0.3	0.3	0.6	0.6	0.6	0.4	0.2	-0.2	-0.7	0.8	0.6	0.4	0.6	0.4	0.6	0.6	0.6	0.6	0.5	0.7	0.6
Number of full sisters	0.3	0.3	1.5	0.1	0.5	-0.0	-0.5	-1.2	-0.7	0.2	0.5	0.5	0.5	0.1	0.8	-0.6	0.2	1.0	0.3	0.2	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.1	0.1	-0.3	0.2	1.1	0.7	-0.8	-0.5	-0.6	0.1	-0.1	-0.2	0.1	-0.3	-0.6	-1.0	-0.7	-0.6	-0.1
Age started oral contraceptive pill	0.3	0.3	1.2	-0.2	0.1	0.1	0.4	0.3	-0.7	-0.7	-0.9	0.4	0.1	-0.9	-0.1	0.2	0.7	-1.1	-0.3	-0.8	-0.2
Basal cell carcinoma (self-reported)	0.3	0.3	1.4	-0.9	-0.3	-0.0	-0.9	0.6	1.2	0.4	0.1	-0.4	-0.3	0.0	-0.5	0.4	-0.9	-0.8	0.0	0.4	-0.3
Pack years of smoking	0.3	0.4	1.5	-0.2	-0.2	-0.7	-0.8	-1.2	0.3	0.3	0.4	-0.6	-0.4	-0.3	-0.1	-0.7	1.2	1.2	0.2	0.2	-0.1
Intelligence (Savage-Jansen 2018)	0.2	0.5	3.0	0.3	-0.1	0.4	0.8	0.6	-0.5	-0.9	-1.0	0.8	0.6	-0.0	0.3	0.4	0.3	-1.7	-0.6	-0.8	-0.3
Worry (Nagel 2018)	0.2	0.5	1.5	0.7	0.9	0.6	0.3	-0.1	-1.2	0.1	-0.1	1.1	0.9	0.7	1.0	0.3	0.9	0.5	0.5	0.0	0.5
Major Depression (MDD)	0.2	0.2	1.2	-0.5	-0.2	-0.2	-0.7	-0.0	0.5	-0.4	-0.6	0.0	-0.2	-0.5	-0.3	-0.3	-0.4	-1.1	-0.3	-0.3	-0.5
Reaction Time	0.2	0.3	1.2	0.4	0.1	0.4	-0.2	0.9	0.6	1.1	0.9	-0.2	0.1	0.6	0.2	0.3	-0.6	-0.2	-0.5	1.1	0.6
Coronary Artery Disease (CAD)	0.2	0.3	1.1	0.7	0.8	0.4	0.6	-0.1	-0.2	0.4	0.3	0.4	0.6	-0.2	0.7	0.2	1.0	-0.2	-0.6	0.5	0.1
Primary Biliary Cirrhosis	0.2	0.2	1.7	0.6	0.6	-0.1	-0.8	-1.3	-0.1	-0.2	-0.1	0.6	0.5	0.0	0.7	-0.0	0.5	-0.1	0.1	-0.1	-0.1
Blood Eosinophil Count	0.2	1.8	7.5	0.2	-1.4	-1.1	0.1	-0.9	0.1	-1.3	-1.7	-0.7	-1.0	-1.8	-0.4	-2.0	-1.2	-1.8	-2.7	-1.5	-1.0
Blood White Count	0.2	1.5	13.1	0.0	-0.1	-0.2	0.1	-0.9	-0.8	1.2	1.8	-0.3	0.0	0.1	0.8	-2.1	0.9	3.6	-0.1	1.2	1.1
BMI	0.2	1.2	4.2	-1.5	-1.1	-0.1	0.5	1.0	1.4	1.0	0.2	-1.1	-0.7	-1.6	-0.8	-0.9	-2.0	-1.6	-1.0	0.8	-0.1
Height	0.2	3.4	15.8	0.2	1.6	0.9	-0.5	-0.3	0.3	2.3	3.5	0.5	0.9	0.6	1.5	-0.9	2.9	4.0	1.9	2.7	1.1
Neuroticism	0.2	0.6	3.6	-0.3	-0.5	-0.7	-1.0	-1.3	0.3	-0.2	0.3	-0.4	-0.4	-0.5	0.0	-1.9	0.4	1.3	-0.6	-0.1	-0.3
Relative age of first facial hair	0.2	0.4	1.4	0.1	-0.3	-0.7	-0.9	-0.2	1.1	0.5	0.5	-1.1	-0.8	0.6	-0.4	-0.4	-0.3	1.2	0.5	0.4	0.3
Impedance of leg (right)	0.2	0.9	4.4	0.2	-0.2	-1.1	-1.8	-2.1	0.5	-1.4	-0.8	-0.2	-0.5	-0.2	-0.5	-0.0	0.8	0.4	-0.3	-1.2	-1.0
Leg fat-free mass (left)	0.2	1.2	5.1	-0.7	0.1	0.7	0.5	1.1	1.1	2.2	2.1	-0.4	0.2	-0.3	0.3	-0.9	-0.4	1.1	0.2	2.2	0.7
Average weekly fortified wine intake	0.2	0.3	1.7	-0.5	-0.2	-0.6	-0.6	-0.7	0.1	-0.4	0.1	-0.4	-0.4	-0.1	-0.1	-1.0	-0.0	1.3	0.0	-0.3	-0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	2.1	0.1	0.3	0.2	0.2	-0.4	-0.7	0.1	0.1	0.4	0.4	-0.2	0.4	-0.3	1.4	-0.1	-0.3	0.1	-0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.7	0.6	0.7	0.2	0.3	-0.2	-0.1	0.6	0.8	0.1	0.2	-0.1	0.7	-0.2	0.9	0.9	-0.2	0.7	0.6
Impedance of leg (left)	0.2	0.8	4.0	0.3	-0.1	-1.0	-1.7	-2.0	0.3	-1.4	-0.9	-0.1	-0.4	-0.2	-0.4	-0.0	0.4	0.2	-0.2	-1.3	-1.0
Leg predicted mass (left)	0.2	1.1	4.7	-0.8	0.1	0.6	0.5	1.0	1.1	2.1	2.0	-0.5	0.1	-0.4	0.2	-0.9	-0.5	1.0	0.1	2.2	0.6
Trunk fat mass	0.2	0.7	3.4	0.0	0.5	0.8	0.3	0.7	0.5	1.8	1.3	0.4	0.7	-0.4	0.7	-0.1	0.2	0.3	0.4	1.7	0.8
Waist circumference	0.2	0.7	3.5	0.1	0.4	1.0	0.6	0.9	0.2	1.9	1.2	0.6	0.9	-0.2	0.8	-0.1	-0.1	-0.1	0.2	1.7	1.0
Nervous feelings	0.2	0.4	2.3	0.3	0.5	0.3	-0.0	-0.6	-1.1	-0.5	-0.2	1.0	0.7	0.1	0.8	-0.4	1.5	0.3	0.1	-0.4	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.4	-0.4	-0.6	-0.6	-0.6	-0.6	0.5	0.1	0.4	-0.7	-0.6	-0.2	-0.3	-1.2	-0.2	0.9	-0.3	0.1	0.2
Financial difficulties in last 2 years	0.2	0.3	0.9	0.1	-0.4	-0.1	0.5	0.4	0.1	0.8	0.7	-0.7	-0.4	0.3	-0.3	-0.0	-0.8	0.7	-0.4	0.7	1.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	1.1	0.4	0.2	0.0	-0.5	-0.7	-0.1	-0.5	-0.7	0.6	0.4	-0.1	0.4	0.2	-0.6	-1.0	-0.2	-0.5	-0.5
Neuroticism score	0.2	0.3	2.0	0.6	-0.1	-0.5	-0.2	-1.1	-0.3	-0.2	0.4	-0.1	-0.2	-0.0	0.3	-1.1	0.7	1.4	-0.3	-0.1	0.2
Weight	0.2	1.2	5.6	-0.3	0.4	0.9	0.6	1.1	0.6	2.4	2.0	0.1	0.6	-0.2	0.6	-0.5	-0.0	1.0	0.6	2.3	1.0
Arm fat percentage (right)	0.2	0.6	1.9	0.1	0.3	0.9	0.9	1.4	0.1	1.4	0.3	0.6	0.7	-0.5	0.5	0.4	-0.7	-1.3	0.1	1.1	0.8
Trunk fat-free mass	0.2	1.2	5.0	-1.0	0.1	0.4	0.2	0.7	1.0	2.1	2.2	-0.6	0.0	-0.3	0.2	-1.1	-0.0	1.7	0.3	2.2	0.6
Time employed in main current job	0.2	0.3	1.9	0.2	-0.0	-0.1	-0.5	0.5	1.4	0.6	0.4	-0.7	-0.4	0.2	-0.4	0.4	-0.4	0.4	0.2	0.5	0.2
Worrier / anxious feelings	0.2	0.5	1.3	-0.7	-0.6	-0.8	-1.1	-1.1	0.6	-0.5	-0.3	-0.6	-0.6	-0.6	-0.4	-1.0	-0.6	-0.1	-0.7	-0.4	-0.7
Happiness	0.2	0.3	1.1	-0.8	-0.4	-0.2	-0.1	0.7	1.1	0.7	0.4	-0.8	-0.5	-0.1	-0.5	-0.7	0.2	-0.1	-0.2	0.6	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.3	-0.7	-0.2	-0.3	-0.7	-0.2	0.9	-0.3	-0.3	-0.2	-0.2	0.0	-0.4	-0.1	-1.1	-0.4	-0.1	-0.3	-0.7
Illnesses of mother	0.2	0.3	1.8	0.3	0.2	-0.1	-0.2	-0.6	-0.1	0.2	0.6	0.1	0.1	0.5	0.5	-0.7	1.0	1.3	0.3	0.3	0.3
Trunk predicted mass	0.2	1.2	5.0	-1.0	0.1	0.4	0.2	0.7	1.0	2.1	2.2	-0.6	0.1	-0.2	0.2	-1.1	0.0	1.7	0.3	2.2	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.2	-0.6	-0.6	0.5	0.4	1.1	-0.1	-0.5	-0.4	0.5	0.3	0.6	-0.1	0.2	-0.6	-0.7	-0.3	-0.5	-0.4
Birth weight	0.2	0.5	2.0	-0.6	-0.5	-0.7	-1.4	-1.1	0.7	-0.7	-0.6	-0.2	-0.3	-0.6	-0.3	-0.8	-0.3	-0.7	-0.2	-0.6	-0.9
Arm fat-free mass (right)	0.2	1.0	2.7	-1.6	-0.5	-0.2	-0.3	0.0	1.4	1.5	1.6	-1.1	-0.5	-1.0	-0.3	-1.6	-0.3	1.3	-0.1	1.5	-0.1
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.5	-0.6	-0.3	0.0	0.7	0.7	-0.4	-0.3	-0.7	-0.6	-0.1	-0.7	0.1	0.2	-0.6	0.2	-0.3	-0.1
Arm predicted mass (right)	0.2	1.2	4.0	-1.2	-0.1	0.0	-0.2	0.2	1.2	1.9	2.0	-0.9	-0.3	-0.6	-0.0	-1.4	-0.2	1.8	0.2	1.9	0.3
Alcohol intake frequency.	0.2	0.4	2.3	0.1	-0.0	0.3	0.5	1.4	0.2	0.2	-0.4	-0.2	-0.2	0.0	-0.4	0.9	-1.2	-1.5	-0.2	0.1	0.0
Comparative height size at age 10	0.2	0.9	4.2	-0.4	0.7	0.8	0.1	0.9	0.6	1.6	2.0	0.0	0.4	0.2	0.5	-0.4	-0.1	1.5	1.1	1.8	0.6
Suffer from ‘nerves’	0.2	0.3	1.1	0.6	0.4	0.7	0.6	1.1	-0.4	0.4	0.5	0.3	0.3	0.2	0.3	0.6	0.5	0.1	0.6	0.5	0.7
Whole body fat-free mass	0.2	1.2	4.6	-1.0	0.0	0.4	0.3	0.8	1.1	2.1	2.1	-0.7	-0.0	-0.4	0.1	-1.1	-0.3	1.4	0.2	2.1	0.5
Leg fat-free mass (right)	0.2	1.1	4.5	-0.7	0.1	0.7	0.8	1.3	0.9	2.1	2.0	-0.4	0.2	-0.3	0.2	-0.9	-0.6	1.0	0.2	2.1	0.6
Mood swings	0.2	0.4	2.8	1.7	0.4	0.0	-0.2	-1.1	-0.6	-0.1	0.0	0.8	0.6	0.3	0.8	0.1	0.5	0.6	0.1	-0.1	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	-0.5	-0.5	0.3	0.0	0.9	0.5	0.6	0.1	-0.2	-0.2	-0.1	-0.4	0.5	-0.7	-0.8	0.1	0.5	-0.2
Mineral and other dietary supplements	0.2	0.3	1.1	-0.5	-0.6	-0.1	0.2	0.7	0.6	-0.2	-0.4	-0.5	-0.4	-0.6	-0.6	-0.2	-0.4	-1.1	-0.6	-0.3	-0.6
Whole body water mass	0.2	1.1	4.2	-1.1	-0.1	0.3	0.2	0.8	1.2	2.0	2.0	-0.8	-0.1	-0.5	-0.0	-1.2	-0.4	1.2	0.0	2.0	0.4
Leg predicted mass (right)	0.2	1.1	4.4	-0.7	0.1	0.7	0.8	1.3	0.9	2.1	2.0	-0.4	0.2	-0.3	0.3	-0.9	-0.6	1.0	0.2	2.1	0.6
Medication: Blood pressure	0.2	0.3	1.6	-0.1	-0.2	-0.2	0.6	0.7	-0.0	-0.0	-0.8	-0.4	-0.4	-0.3	-0.5	0.5	-1.1	-1.2	-0.0	-0.3	-0.1
Basal metabolic rate	0.2	1.2	5.0	-0.9	0.0	0.5	0.3	0.8	1.2	2.2	2.1	-0.6	0.1	-0.4	0.2	-1.1	-0.3	1.3	0.2	2.2	0.6
Arm fat-free mass (left)	0.2	1.1	4.3	-1.0	-0.1	0.3	0.3	0.6	1.1	2.1	2.0	-0.7	-0.0	-0.5	0.1	-1.1	-0.3	1.3	0.2	2.1	0.5
Number of operations (self-reported)	0.2	0.3	2.3	0.0	0.5	-0.0	-1.2	-1.0	0.1	0.2	0.1	0.4	0.3	-0.4	0.5	-0.1	1.5	0.1	0.4	0.2	0.0
Average weekly beer plus cider intake	0.2	0.2	0.6	0.3	0.5	0.6	0.0	0.4	-0.6	0.3	0.5	0.8	0.6	0.4	0.7	0.1	0.6	0.6	0.5	0.3	0.5
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.7	-0.1	0.6	0.3	0.6	0.9	-0.3	0.7	0.6	-0.1	0.0	-0.0	0.2	-0.2	0.3	0.7	0.2	0.6	0.5
Supplements: Calcium	0.2	0.2	1.1	0.3	0.7	-0.2	-0.7	-1.0	-0.2	-0.4	-0.4	0.5	0.3	-0.2	0.5	0.1	0.7	-0.3	-0.1	-0.4	-0.3
Arm predicted mass (left)	0.2	1.1	3.9	-1.2	-0.3	0.2	0.1	0.5	1.2	2.0	1.9	-0.8	-0.1	-0.6	-0.0	-1.2	-0.5	1.2	0.2	2.0	0.4
HbA1C	0.1	0.1	0.7	-0.6	-0.2	0.0	-0.9	-0.5	0.5	-0.1	0.0	0.2	0.1	-0.3	0.1	-0.6	0.3	0.2	0.2	-0.1	-0.1
Lupus	0.1	0.1	0.3	-0.5	-0.4	-0.2	-0.5	0.1	0.1	-0.4	-0.4	-0.1	-0.2	-0.1	-0.4	-0.2	-0.4	-0.1	0.2	-0.2	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	-0.2	0.2	-0.1	-0.3	-0.1	0.4	-0.4	-0.6	0.3	0.2	-0.2	0.3	0.0	-0.3	-0.7	0.1	-0.5	-0.3
Waist Hip Ratio (WHR)	0.1	0.6	1.9	-0.8	-0.7	-0.6	-1.3	-1.4	0.9	-0.1	0.4	-0.5	-0.4	-0.8	-0.1	-1.4	1.2	0.6	-0.6	0.1	-0.2
Hypothyroidism (self reported)	0.1	0.2	1.8	0.1	0.2	-0.5	-0.6	-1.3	0.0	-0.3	-0.3	-0.1	-0.1	-0.8	-0.1	-0.0	-0.7	-0.2	-0.5	-0.3	-0.5
Chronotype (morning person)	0.1	0.2	1.5	0.0	0.1	0.6	0.4	1.2	-0.3	0.3	-0.0	0.5	0.5	0.7	0.4	0.4	0.3	-0.6	0.5	0.2	0.3
Hair Pigment	0.1	1.9	13.2	-1.5	-1.1	0.3	0.6	3.6	1.3	0.4	-0.3	-1.4	-1.1	0.7	-1.4	1.1	-1.1	-2.5	0.5	0.3	0.0
Tanning	0.1	1.3	8.6	0.2	0.2	-0.7	-1.2	-2.9	-0.2	0.2	0.7	0.3	0.3	-1.2	0.7	-2.1	1.1	1.6	-1.0	0.3	0.0
Trunk fat percentage	0.1	0.4	1.9	0.1	0.4	0.7	0.1	0.7	0.5	1.4	0.8	0.5	0.6	-0.5	0.5	0.0	0.2	-0.2	0.3	1.3	0.6
Townsend deprivation index at recruitment	0.1	0.2	0.8	-0.5	-0.9	-0.4	0.1	0.3	0.3	-0.2	-0.3	-0.6	-0.6	-0.3	-0.5	-0.6	-0.3	-0.2	-0.3	-0.3	-0.0
Qualifications: CSEs or equivalent	0.1	0.1	0.6	0.8	0.2	0.4	-0.0	-0.0	0.1	0.3	0.4	0.4	0.5	0.7	0.4	0.4	-0.2	0.2	0.2	0.4	0.2
High blood pressure (mother)	0.1	0.2	1.5	-0.1	-0.1	0.2	0.5	0.4	-0.0	-0.0	-0.1	-0.0	-0.1	-0.2	-0.3	0.8	-1.2	-0.5	-0.1	-0.1	0.1
Body mass index (BMI)	0.1	0.4	1.1	-0.6	-0.4	0.2	0.5	0.8	0.5	1.0	0.1	-0.2	0.1	-0.9	-0.1	-0.4	-1.0	-0.9	-0.4	0.8	0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	-0.0	-0.6	-0.3	-0.1	0.4	-0.1	0.0	0.1	-0.7	-0.5	0.3	-0.4	-0.2	-0.3	0.5	-0.3	-0.0	0.1
Had other major operations	0.1	0.1	0.5	-0.6	0.1	-0.1	-0.1	0.3	0.1	0.2	-0.1	-0.5	-0.4	-0.5	-0.3	-0.1	-0.7	-0.7	-0.1	0.1	0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.3	0.4	-0.0	0.3	-0.4	-0.3	0.2	0.3	0.2	0.2	0.1	0.4	-0.5	-0.1	0.4	-0.4	0.2	0.0
Impedance of arm (right)	0.1	0.4	1.8	1.2	0.7	0.8	0.3	0.8	-0.2	-0.2	-0.1	0.9	0.6	0.8	0.3	1.3	0.4	-0.7	0.3	-0.1	0.2
Impedance of arm (left)	0.1	0.5	1.6	1.2	1.0	0.7	0.0	0.4	-0.5	-0.5	-0.1	1.1	0.7	0.9	0.5	1.3	0.8	-0.3	0.5	-0.3	0.1
Arm fat mass (right)	0.1	0.5	2.6	-0.4	0.1	0.8	0.6	1.0	0.4	1.6	0.9	0.3	0.6	-0.6	0.4	-0.2	-0.6	-0.4	0.1	1.4	0.7
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.2	0.4	0.4	0.5	0.5	-0.3	0.1	0.2	0.3	0.1	-0.1	0.3	0.1	-0.3	-0.0	-0.4	0.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	2.3	0.2	0.3	-0.6	-0.5	-1.5	-0.4	-0.4	-0.3	-0.0	-0.1	-0.7	0.1	-0.3	0.4	0.4	-0.6	-0.4	-0.4
Medication: Amlodipine	0.1	0.2	0.8	0.9	0.6	0.1	0.3	-0.7	-0.5	-0.1	0.2	0.4	0.3	0.0	0.7	-0.2	0.3	0.3	-0.7	-0.0	0.2
Body fat percentage	0.1	0.3	1.8	0.0	0.3	0.6	0.2	0.5	0.4	1.4	0.6	0.4	0.6	-0.6	0.4	-0.1	0.0	-0.3	0.2	1.2	0.6
Number of children fathered	0.1	0.2	0.7	-0.5	-0.2	-0.5	-0.2	-0.4	0.6	0.2	-0.2	-0.5	-0.3	-0.7	-0.3	-0.8	-0.2	-0.1	-0.2	-0.0	-0.2
Qualifications: College or University degree	0.1	0.2	1.2	0.4	-0.1	0.2	0.6	0.3	-0.8	-0.4	-0.4	0.2	0.1	0.4	0.2	0.2	1.1	-0.5	-0.4	-0.4	0.1
Migraine (self-reported)	0.1	0.1	1.0	-0.5	-0.2	-0.1	0.4	0.1	-0.2	-0.5	-0.1	-0.2	-0.3	-0.3	-0.3	-1.0	-0.1	0.4	-0.3	-0.4	-0.4
Medication: Allopurinol	0.1	0.2	0.8	-0.7	0.1	0.3	-0.5	0.1	0.3	0.5	0.1	0.3	0.4	-0.3	0.2	-0.0	-0.3	-0.9	0.1	0.4	-0.3
Whole body fat mass	0.1	0.5	2.7	-0.2	0.3	0.6	0.3	0.5	0.4	1.6	1.1	0.4	0.6	-0.6	0.6	-0.4	0.0	0.2	0.3	1.5	0.7
Leg fat mass (right)	0.1	0.3	1.3	-0.4	-0.1	0.2	-0.0	-0.2	0.6	1.2	0.5	0.1	0.4	-0.9	0.3	-0.7	-0.3	-0.1	-0.0	1.0	0.2
Supplements: Vitamin C	0.1	0.1	0.3	-0.1	0.0	-0.0	-0.3	-0.2	-0.2	-0.3	-0.6	0.4	0.2	-0.1	0.1	0.1	0.1	-0.4	0.2	-0.4	-0.2
Knee pain experienced in last month	0.1	0.1	0.7	0.2	0.1	-0.1	0.1	0.2	0.1	0.5	0.2	-0.4	-0.3	-0.1	0.1	0.1	0.8	0.2	0.1	0.4	0.6
Illnesses of father: Heart disease	0.1	0.2	0.6	-0.2	-0.2	-0.2	0.8	0.7	-0.2	-0.3	-0.6	-0.3	-0.4	-0.1	-0.4	-0.2	-0.8	-0.1	-0.6	-0.5	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	1.0	-0.1	-0.3	-0.2	-0.1	-0.6	0.2	0.6	0.9	-0.4	-0.2	0.0	-0.1	-0.4	-0.1	1.0	-0.1	0.7	0.1
Arm fat percentage (left)	0.1	0.6	1.7	0.2	0.5	1.0	0.8	1.2	-0.1	1.3	0.3	0.8	0.9	-0.4	0.6	0.5	-0.6	-1.2	0.2	1.1	0.7
Qualifications: nursing, teaching	0.1	0.1	0.3	-0.2	0.3	0.2	0.4	0.0	-0.3	-0.1	-0.1	0.2	0.2	-0.4	0.3	-0.4	0.5	-0.4	-0.4	-0.1	-0.1
Osteoarthritis (self-reported)	0.1	0.1	0.8	0.0	0.2	-0.1	0.4	-0.3	-0.9	-0.4	-0.5	0.2	0.0	-0.4	0.0	-0.1	0.2	-0.0	0.1	-0.5	0.2
Arm fat mass (left)	0.1	0.5	2.5	-0.3	0.2	0.8	0.6	0.9	0.3	1.6	0.8	0.4	0.7	-0.6	0.5	-0.1	-0.7	-0.5	0.1	1.4	0.6
Miserableness	0.1	0.2	0.6	0.1	-0.2	-0.1	0.1	0.1	0.7	0.6	0.5	-0.4	-0.3	-0.1	-0.1	-0.8	-0.2	0.3	-0.7	0.6	0.2
Wears glasses or contact lenses	0.1	0.1	0.3	-0.5	-0.2	-0.1	0.2	0.2	0.0	0.1	0.1	-0.2	-0.2	-0.3	-0.3	-0.4	0.3	0.4	0.0	0.1	0.1
Hearing aid user	0.1	0.2	0.6	0.8	0.5	0.4	0.2	0.3	-0.1	0.3	0.3	0.3	0.2	0.3	0.3	0.7	0.6	0.2	-0.2	0.3	0.3
Medication: Bendroflumethiazide	0.1	0.1	0.7	-0.5	-0.2	0.2	0.1	0.1	-0.2	0.0	-0.2	0.3	0.2	-0.4	-0.1	0.2	0.1	-0.8	-0.2	0.0	-0.4
Myopia	0.1	0.1	0.8	-0.0	-0.1	-0.1	0.8	-0.1	-0.7	-0.2	-0.3	0.0	0.1	-0.2	-0.0	-0.3	-0.9	-0.3	-0.2	-0.2	0.1
Impedance of whole body	0.1	0.4	1.4	1.2	0.8	0.2	-0.7	-0.6	-0.2	-0.5	0.0	0.7	0.4	0.8	0.4	1.0	1.1	0.5	0.7	-0.3	0.0
Leg fat mass (left)	0.1	0.3	1.3	-0.4	-0.0	0.2	0.1	-0.1	0.5	1.1	0.5	0.1	0.4	-0.9	0.3	-0.6	-0.5	-0.1	0.0	1.0	0.3
Hand grip strength (right)	0.0	0.1	0.7	-0.1	0.2	0.0	0.4	-0.0	0.1	-0.1	-0.2	-0.0	-0.1	-0.0	-0.1	0.0	-0.8	-0.2	-0.4	-0.1	-0.6
Leg fat percentage (right)	0.0	0.2	0.9	-0.3	-0.2	-0.1	-0.3	-0.5	0.6	0.7	-0.1	0.1	0.2	-0.9	0.0	-0.3	-0.2	-0.7	-0.1	0.4	0.1
Leg fat percentage (left)	0.0	0.2	0.8	-0.1	-0.1	-0.0	-0.1	-0.3	0.4	0.7	-0.2	0.2	0.3	-0.9	0.1	-0.2	-0.5	-0.8	-0.0	0.4	0.2

Hub : Genes

FRG1B

Models

Trait associations