Hub : Genes

FXYD3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.322	0.1047	9.4e-03	-0.008	NA	0.054	NA	-0.008	9.4e-01	NA	0.00530	NA	9.6e-01
2	GTEx	Artery Tibial	0.364	0.0848	5.2e-06	0.047	NA	0.009	NA	0.015	1.4e-04	NA	0.05800	NA	2.1e-02
3	GTEx	Skin Not Sun Exposed Suprapubic	0.245	0.0810	2.0e-03	0.089	NA	0.062	NA	0.079	1.4e-05	NA	0.00027	NA	3.9e-05
4	GTEx	Skin Sun Exposed Lower leg	0.126	0.0500	7.7e-03	0.064	NA	0.030	NA	0.065	5.3e-06	NA	0.00150	NA	4.6e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.2	0.2	-0.4	0.4	-0.4	-0.2
Bipolar Disorder or Schizophrenia	0.2	0.6	2.1	0.0	1.5	0.2	-0.1
Depressed Affect (Nagel 2018)	2.0	4.2	8.6	-0.5	-0.6	-2.8	-2.9
Depression (Nagel 2018)	0.3	0.5	1.2	-1.1	0.8	-0.0	-0.3
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.5	-0.2	-1.6	-0.1	0.0
Neuroticism (Nagel 2018)	2.0	4.7	9.8	-1.7	-0.5	-2.4	-3.1
Schizophrenia (2018)	0.4	0.8	2.3	0.6	1.5	0.6	0.1
Schizophrenia vs Biploar Disorder	0.2	0.2	0.5	0.2	-0.2	-0.7	-0.6
Worry (Nagel 2018)	0.7	1.6	2.4	-1.6	-0.7	-1.0	-1.6
Alzheimer’s Disease (in mother)	4.5	5.2	8.6	0.8	-1.8	-2.9	-2.9
Alzheimer’s Disease (in father)	0.4	0.4	1.2	-0.6	-1.1	-0.4	-0.0
Alzheimer’s Disease (including proxy)	2.5	3.6	5.4	-0.2	-2.1	-2.3	-2.1
Crohns Disease (2017)	0.8	1.7	2.9	-0.8	1.1	-1.4	-1.7
Irritable Bowel Disease (IBD)	1.4	3.3	6.3	0.4	0.9	-2.5	-2.4
Ulcerative Colitis (UC)	1.1	2.1	3.8	1.4	0.5	-1.9	-1.6
Major Depression (MDD)	0.1	0.1	0.5	0.0	-0.0	-0.7	0.0
Reaction Time	0.2	0.3	0.5	-0.7	0.7	-0.3	-0.6
Verbal and Numeric Reasoning (VNR)	0.8	1.8	5.1	-0.5	-2.3	-1.1	-0.8
Breast Cancer	0.9	2.3	5.8	-2.4	0.3	1.4	1.1
Ovarian Cancer	0.8	1.0	2.0	-0.3	-1.4	0.9	1.0
Prostate Cancer	0.5	0.6	1.5	-0.2	0.9	1.2	0.5
Age at First Birth	0.6	0.8	2.3	-0.4	0.6	1.5	0.8
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.2	2.1	0.0	-0.7	1.4	1.5
Coronary Artery Disease (CAD)	0.4	0.4	1.2	1.1	0.6	0.4	0.0
Crohns Disease (2012)	1.5	2.4	3.8	-1.2	-0.6	-1.9	-1.9
Mean Putamen Volume	0.3	0.4	1.1	1.1	-0.1	-0.4	0.5
Fasting Glucose	1.0	1.2	3.1	1.8	-1.1	-0.5	-0.6
HbA1C	0.9	1.0	2.0	-0.6	1.1	1.4	0.8
HDL Cholesterol	1.0	1.7	3.6	-0.8	-0.1	-1.6	-1.9
LDL Cholesterol	0.2	0.3	0.7	0.1	0.9	-0.1	-0.6
Lupus	1.2	1.9	2.9	1.4	-0.3	-1.7	-1.6
Neuroticism (2016)	2.5	3.7	7.7	0.6	0.2	-2.6	-2.8
Primary Biliary Cirrhosis	0.3	0.5	1.0	0.1	1.0	-0.8	-0.6
Rheumatoid Arthritis	0.1	0.2	0.3	-0.5	-0.4	-0.5	-0.1
Schizophrenia (2014)	0.5	1.0	3.3	0.2	1.8	0.8	0.3
Triglycerides	0.3	0.5	2.1	-0.2	1.4	0.2	0.1
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.8	-1.2	1.7	-1.2	0.0
Ulcerative Colitis	1.7	2.4	3.5	0.4	1.9	-1.7	-1.7
Blood Eosinophil Count	0.0	0.3	0.8	0.2	-0.1	-0.9	-0.6
Blood Platelet Count	1.3	15.3	31.1	-1.0	-1.2	-5.6	-5.3
Blood Red Count	0.3	2.7	4.6	2.1	0.5	1.8	1.7
Blood White Count	0.2	1.6	1.9	1.3	-0.9	-1.4	-1.4
Heel T-Score	0.1	0.4	1.6	0.1	1.2	0.1	0.3
BMI	0.5	3.0	5.6	0.2	-2.0	-2.4	-1.6
Height	0.1	1.8	4.3	0.4	-0.8	-2.1	-1.4
Waist Hip Ratio (WHR)	0.1	0.4	1.0	-0.6	1.0	-0.3	-0.4
Systolic Blood Pressure	0.2	1.0	2.2	-1.5	-0.9	-0.8	-0.7
Smoking Status	2.1	5.1	9.6	1.3	0.1	-3.0	-3.1
Allergy or Eczema	0.1	0.3	0.5	0.7	-0.5	0.3	0.7
Cardiovascular Disease	0.1	0.4	0.6	-0.0	-0.6	-0.8	-0.8
Hypothyroidism (self reported)	0.5	1.2	3.0	-0.0	-0.2	1.4	1.7
Respiratory disease	0.1	0.2	0.7	0.1	-0.8	-0.1	0.1
Type 2 Diabetes (T2D) (2018)	1.1	2.0	4.0	0.5	0.0	-2.0	-1.9
Lung FEV1/FVC ratio	0.0	0.0	0.1	-0.0	-0.1	0.2	-0.3
Lung FVC	0.1	0.6	2.2	-1.5	-0.5	-0.2	0.2
Neuroticism	1.9	4.7	9.7	-1.3	-1.1	-2.5	-3.1
Chronotype (morning person)	1.0	2.4	4.8	1.1	0.4	1.9	2.2
Hair Pigment	0.0	0.6	1.7	-0.3	-1.3	-0.8	-0.4
Tanning	0.2	2.6	3.4	-1.6	-1.1	-1.8	-1.9
Hand grip strength (left)	0.2	0.5	1.2	0.5	-0.3	0.8	1.1
Number of treatments/medications taken	0.7	1.3	2.0	-1.0	0.4	-1.4	-1.4
Average weekly spirits intake	0.9	1.1	1.8	1.0	0.5	-1.2	-1.4
Sensitivity / hurt feelings	0.4	0.7	1.3	-0.5	0.7	-0.7	-1.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	-0.7	0.8	0.2	0.1
Hearing difficulty/problems: Yes	0.5	0.8	1.6	-1.2	-0.3	-0.9	-0.7
Relative age of first facial hair	0.3	0.6	0.9	-0.9	0.9	0.8	0.4
Other serious medical condition/disability diagnosed by doctor	3.2	4.1	7.7	-0.6	1.5	2.8	2.5
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.0	-1.7	-0.1	-1.2	-1.2
Ever had hysterectomy (womb removed)	1.7	1.9	3.1	-1.8	-0.6	-1.5	-1.4
Systolic blood pressure, automated reading	0.6	1.7	2.5	0.2	-1.3	-1.6	-1.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	0.5	0.1	0.4	0.6
Angina	1.8	2.4	5.5	-2.4	1.1	-1.2	-1.2
Medication for hormone replacement therapy	0.3	0.3	1.0	-1.0	-0.3	0.1	0.1
Vitamin and mineral supplements	0.5	0.6	1.5	0.4	1.2	-0.4	-0.9
Supplements: Zinc	0.6	0.7	1.4	-1.2	-1.0	0.2	0.6
Medication: Co-codamol	1.5	1.8	2.2	1.3	1.5	1.3	1.2
Medication: Metformin	0.5	0.7	1.0	0.9	-0.1	-1.0	-0.9
Diabetes (father)	0.2	0.3	0.8	-0.9	0.2	0.3	0.3
Diabetes (mother)	0.6	0.8	1.7	0.8	-0.3	0.8	1.3
Severe depression (siblings)	2.0	2.2	7.1	-2.7	1.1	0.7	0.0
Pack years adult smoking proportion	0.9	1.4	4.8	0.1	-2.2	-0.6	-0.4
Impedance of leg (right)	0.4	2.1	5.6	-0.6	2.4	1.3	1.0
Leg fat-free mass (left)	0.7	4.0	6.6	-0.2	-2.6	-2.4	-1.9
Trunk fat percentage	0.8	3.2	5.8	-1.0	-0.7	-2.4	-2.4
Hand grip strength (right)	0.6	1.7	4.6	0.0	-0.0	1.5	2.1
Townsend deprivation index at recruitment	0.4	0.6	1.1	0.3	0.1	-1.0	-1.0
Current tobacco smoking	0.2	0.4	1.1	-0.2	0.5	1.0	0.5
Average weekly fortified wine intake	1.2	1.4	2.5	1.6	-0.2	1.4	1.1
Maternal smoking around birth	0.2	0.3	0.7	-0.2	0.5	-0.7	-0.8
Fed-up feelings	0.6	1.1	2.1	0.3	-0.4	-1.5	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	3.0	-1.7	1.6	0.2	-0.4
Relative age voice broke	1.1	1.6	3.1	-0.3	1.4	1.8	1.2
Taking other prescription medications	2.5	3.8	7.8	-2.8	1.8	-1.5	-1.5
Age when periods started (menarche)	0.4	0.9	2.4	1.6	-1.1	-0.4	0.1
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.8	-1.3	-0.9	-0.8	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	0.8	0.1	0.5	0.9
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.2	-0.2	-0.4	-0.2
Qualifications: CSEs or equivalent	0.7	0.9	1.4	-1.1	1.2	1.0	0.2
Serious illness, injury or assault to yourself	1.6	2.0	2.7	-1.4	0.8	1.6	1.7
High blood pressure	0.7	2.0	3.0	-0.8	-1.4	-1.6	-1.7
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	-0.4	-0.4	0.3	0.7
Multivitamins +/- minerals	0.5	0.6	1.8	-0.6	-1.4	-0.1	0.3
Stomach or abdominal pain in last month	1.5	1.9	5.5	2.4	-0.4	0.5	1.2
Supplements: Glucosamine	0.6	0.8	2.2	0.3	-1.5	-0.9	-0.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.5	1.6	0.0	-0.4	0.1
Medication: Atenolol	2.7	3.4	4.9	-2.1	-0.8	-2.2	-1.9
Medication: Levothyroxine sodium	0.9	1.5	3.1	0.9	-0.2	1.4	1.7
Sitting height	0.3	2.3	5.6	-0.7	-0.6	-2.4	-1.6
Chronic bronchitis/emphysema (father)	3.0	3.5	7.0	1.0	0.8	2.3	2.6
High blood pressure (mother)	0.3	0.5	1.4	-0.2	0.1	-0.7	-1.2
Body mass index (BMI)	0.8	3.3	4.8	-0.5	-2.0	-2.2	-2.0
Impedance of leg (left)	0.5	2.5	7.2	-0.5	2.7	1.3	1.0
Leg predicted mass (left)	0.7	3.9	6.5	-0.1	-2.5	-2.4	-1.9
Trunk fat mass	1.0	4.2	7.5	-0.9	-1.4	-2.7	-2.6
Waist circumference	1.0	3.6	6.0	-0.9	-1.9	-2.4	-2.0
Number of incorrect matches in round	0.7	1.1	2.5	0.7	0.0	-1.2	-1.6
Past tobacco smoking	6.5	11.9	23.6	-1.3	-0.6	4.7	4.9
Alcohol usually taken with meals	0.1	0.1	0.3	-0.3	-0.6	0.1	0.0
Nervous feelings	0.3	0.6	1.5	-0.1	-0.3	-0.9	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.2	-0.0	0.2	-0.0	-0.5
Hearing difficulty/problems with background noise	1.6	2.6	4.1	-2.0	-1.5	-1.5	-1.3
Hair/balding pattern: Pattern 2	0.2	0.3	1.0	-0.0	-1.0	0.0	0.2
Had menopause	0.6	0.8	2.0	0.1	-0.0	1.4	1.1
Had other major operations	0.9	1.1	2.7	-0.8	-1.6	-0.6	-0.9
Forced vital capacity (FVC)	0.1	0.2	0.6	-0.2	-0.5	0.2	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.0	0.4	1.0	0.1	0.2
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.4	1.1	1.9	0.6	0.7
Qualifications: None of the above	0.4	0.8	1.8	0.2	0.6	-1.3	-1.0
Financial difficulties in last 2 years	0.7	0.9	1.5	-0.3	1.2	1.0	0.9
Mouth/teeth dental problems	1.0	1.5	3.1	-0.8	-0.6	1.8	1.4
Heart attack	1.4	1.7	2.9	-0.7	-1.4	-1.7	-1.3
Allergy	0.1	0.1	0.3	0.5	0.4	0.4	0.1
Pain all over the body in last month	0.2	0.2	0.6	-0.1	-0.8	-0.3	-0.3
Diabetes (self-reported)	0.1	0.2	0.3	0.6	0.3	-0.4	-0.3
Hayfever/allergic rhinitis (self-reported)	2.2	3.0	5.0	2.2	-2.2	0.5	1.3
Medication: Ramipril	0.1	0.1	0.1	-0.4	-0.2	0.4	0.3
Medication: Simvastatin	1.6	2.4	3.1	-1.7	0.8	-1.6	-1.8
Fluid intelligence score	0.3	0.7	1.7	-1.0	-1.3	0.2	0.3
Illnesses of siblings	0.3	0.4	1.3	-0.3	-1.2	0.3	0.5
Neuroticism score	1.0	2.1	3.8	-1.3	-0.7	-1.6	-2.0
Weight	0.9	4.4	7.5	-0.7	-2.0	-2.7	-2.4
Impedance of arm (right)	0.4	2.0	6.0	-0.3	2.5	1.1	0.8
Arm fat percentage (right)	1.1	4.4	7.7	-0.9	-1.4	-2.8	-2.7
Trunk fat-free mass	0.5	2.7	4.4	0.1	-2.1	-2.0	-1.5
Hip circumference	0.9	3.7	5.9	-0.9	-2.4	-2.2	-1.8
Time employed in main current job	0.2	0.2	0.8	0.1	-0.1	-0.5	-0.9
Alcohol intake versus 10 years previously	1.3	2.0	3.8	-0.1	-0.8	-1.9	-1.8
Father’s age at death	0.9	1.2	2.4	-1.5	0.9	-0.8	-1.0
Worrier / anxious feelings	0.7	1.4	5.1	-2.3	0.2	0.6	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.5	-0.4	1.2	-1.0	-1.0
Falls in the last year	0.5	0.6	1.7	-0.4	1.3	0.6	0.5
Hair/balding pattern: Pattern 3	0.2	0.2	0.5	-0.1	-0.2	-0.6	-0.7
Number of live births	0.4	0.6	1.4	0.3	1.2	0.7	0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.3	-0.1	-0.3	0.6	1.1
Pulse rate	1.4	2.3	7.0	-0.4	2.6	1.2	0.7
Happiness	0.0	0.0	0.1	0.3	-0.3	0.0	0.2
Noisy workplace	0.6	0.7	1.4	0.7	0.4	1.2	0.9
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.2	-1.0	-0.2	1.5	1.4
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	2.0	-1.4	0.7	1.2	1.2
Mouth/teeth dental problems: Dentures	2.2	3.8	6.6	1.1	0.8	-2.6	-2.5
Asthma	0.1	0.3	0.8	0.9	-0.0	-0.5	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.5	-0.7	1.2	-0.5	-0.9
Medication: Cholesterol lowering	0.4	0.6	1.2	-1.1	1.0	-0.3	-0.4
Depression (self-reported)	0.5	0.6	2.3	-0.2	1.5	0.4	0.1
Medication: Lansoprazole	0.8	0.9	2.1	0.4	-0.3	1.1	1.4
Prospective memory result	1.2	1.5	2.8	1.7	-0.8	-1.1	-1.2
Lung cancer (father)	0.3	0.3	0.5	-0.6	0.2	-0.7	-0.5
Illnesses of mother	0.0	0.0	0.0	-0.2	0.1	0.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.2	-0.9	0.2	0.7	1.1
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1
Impedance of arm (left)	0.5	2.3	4.5	-0.3	2.1	1.6	1.4
Arm fat mass (right)	1.1	4.3	7.9	-0.4	-1.6	-2.8	-2.6
Trunk predicted mass	0.4	2.5	4.4	-0.0	-2.1	-1.9	-1.4
Standing height	0.1	0.8	2.2	-0.5	-0.1	-1.5	-0.9
Length of working week for main job	0.3	0.3	0.7	0.6	0.8	0.3	0.2
Exposure to tobacco smoke at home	1.3	1.5	2.4	1.2	1.6	1.0	1.0
Breastfed as a baby	0.4	0.5	0.8	0.5	-0.9	0.9	0.6
Tense / ‘highly strung’	1.0	1.6	2.8	-1.1	-0.6	-1.4	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.8	-0.9	1.4	-0.8	-0.6
Hair/balding pattern: Pattern 4	0.4	0.9	3.6	-0.2	-1.9	-0.4	-0.1
Birth weight of first child	0.3	0.6	0.9	1.0	0.3	-0.7	-0.9
Peak expiratory flow (PEF)	0.5	1.0	2.0	0.2	0.7	1.3	1.4
Pulse wave reflection index	1.0	1.2	2.7	0.7	-1.6	-0.9	-0.9
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.1	-0.3	1.8	-0.7	-1.1
Loud music exposure frequency	0.2	0.2	0.4	-0.6	-0.2	-0.1	0.5
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	3.8	-2.0	0.7	1.4	0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	0.3	-0.9	-0.5	-0.0
Blood clot in the leg (DVT)	0.6	0.8	1.5	1.1	0.3	0.7	1.2
Medication: Paracetamol	1.3	2.1	3.4	1.5	-0.0	-1.7	-1.9
Headache pain in last month	0.5	0.8	1.3	-0.2	1.1	0.9	1.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	1.0	-0.5	0.0	0.1
Glaucoma (self-reported)	2.0	2.4	3.1	-1.7	-1.8	-1.4	-1.3
Gout (self-reported)	0.2	0.3	0.7	0.8	0.8	-0.0	0.3
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	6.5	0.5	-0.3	2.1	2.5
Medication: Amlodipine	0.4	0.5	1.4	0.0	-0.4	-1.2	-0.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.5	1.9	-0.1	-0.2	0.1
Birth weight	0.4	1.0	1.4	0.5	-1.1	-1.2	-1.1
Chronic bronchitis/emphysema (mother)	1.9	2.3	5.8	-0.8	2.4	1.1	1.2
High blood pressure (siblings)	0.3	0.4	0.7	-0.3	0.8	0.8	0.5
Forced vital capacity (FVC), Best measure	0.1	0.4	0.7	-0.8	0.2	0.4	0.9
Body fat percentage	1.0	4.0	6.9	-1.0	-1.3	-2.6	-2.6
Leg fat percentage (right)	1.0	3.6	6.0	-0.9	-1.4	-2.4	-2.5
Arm fat-free mass (right)	0.7	3.3	5.4	-0.2	-2.3	-2.2	-1.7
Exposure to tobacco smoke outside home	0.9	1.2	1.7	-1.0	-0.7	-1.2	-1.3
Comparative body size at age 10	0.9	2.4	3.0	-1.7	-1.7	1.4	1.3
Number of full brothers	0.6	0.8	1.6	-1.3	-0.5	-0.9	-0.6
Worry too long after embarrassment	1.0	1.7	5.3	-2.3	-1.0	0.8	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.4	-1.2	1.0	-0.4	-0.4
Wheeze or whistling in the chest in last year	0.3	0.5	1.2	0.7	-1.1	-0.3	-0.4
Number of children fathered	0.7	0.8	1.4	-0.6	-1.2	-0.9	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.7	0.8	0.2	1.5	1.6
Age at first live birth	0.7	1.2	2.6	0.4	-0.3	1.6	1.4
Pulse wave peak to peak time	0.0	0.0	0.1	0.0	0.0	0.2	0.3
Health satisfaction	0.1	0.1	0.2	-0.4	0.2	-0.2	-0.4
Shortness of breath walking on level ground	0.1	0.2	0.6	0.8	-0.1	-0.0	0.1
Qualifications: College or University degree	0.1	0.2	0.5	-0.2	-0.1	0.4	0.7
Eye problems/disorders: None of the above	0.6	0.7	1.4	-0.9	1.2	-0.3	-0.7
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.5	1.0	1.2	0.8	0.7
Emphysema/chronic bronchitis	0.5	0.6	1.9	-1.4	-0.3	-0.2	-0.6
Medication for pain relief, constipation, heartburn	1.2	2.0	3.9	-0.7	0.1	2.0	1.9
Neck or shoulder pain in last month	0.6	0.9	1.6	-0.0	-1.3	-1.1	-0.9
Medication: Blood pressure	0.2	0.4	1.1	-0.6	1.1	0.3	0.1
Angina (self-reported)	1.9	2.5	6.4	-2.5	1.0	-1.1	-1.1
Migraine (self-reported)	0.8	0.9	2.1	0.3	1.4	1.0	0.8
Medication: Ibuprofen	0.7	0.9	2.8	-0.6	1.7	-0.0	-0.5
Medication: Allopurinol	0.4	0.5	1.0	-0.3	0.7	-0.7	-1.0
Medication: Omeprazole	1.2	1.4	3.0	-0.8	-0.4	-1.3	-1.7
Medication: Seretide 50 evohaler	3.3	3.8	5.5	-1.2	2.0	2.4	2.1
Mean time to correctly identify matches	0.1	0.3	0.4	-0.6	0.5	-0.4	-0.6
Heart disease (mother)	1.5	1.8	5.1	-0.8	-2.3	-1.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.7	4.4	9.5	0.3	0.4	2.8	3.1
Whole body fat mass	1.0	4.0	7.0	-0.8	-1.6	-2.6	-2.4
Leg fat mass (right)	1.1	4.2	6.4	-0.7	-2.1	-2.5	-2.4
Arm predicted mass (right)	0.6	3.2	4.9	-0.3	-2.2	-2.2	-1.7
Pulse rate, automated reading	0.3	0.9	1.3	0.9	0.7	0.9	1.1
Alcohol intake frequency.	0.5	1.2	3.5	-1.9	-0.8	0.2	0.7
Comparative height size at age 10	0.2	1.1	3.0	-0.2	0.3	-1.7	-1.1
Number of full sisters	1.2	1.4	2.6	0.5	1.6	1.2	1.1
Suffer from ‘nerves’	0.1	0.2	0.4	-0.1	-0.2	-0.5	-0.6
Overall health rating	0.1	0.2	0.5	-0.5	0.2	-0.4	-0.7
Chest pain or discomfort	2.3	3.4	11.4	-3.4	1.3	0.6	-0.1
Had major operations	1.0	1.2	2.3	-1.1	0.1	-1.1	-1.5
Age at last live birth	1.9	2.8	4.4	1.2	1.0	2.1	2.1
Family relationship satisfaction	0.5	0.6	0.9	-0.9	0.9	-0.4	-0.9
Leg pain on walking	0.3	0.3	0.8	-0.0	0.9	-0.5	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.9	-0.0	-1.0	0.8	1.0
Commuting to job workplace: Car/motor vehicle	3.0	3.4	5.6	-1.7	0.4	-2.3	-2.4
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.6	1.0	-1.6	-0.3	-0.0
Medication: Aspirin	0.8	1.0	1.8	1.1	0.4	-1.4	-1.0
Supplements: Vitamin C	1.5	1.8	4.5	-0.6	-0.1	1.5	2.1
Knee pain experienced in last month	0.5	0.7	1.9	0.4	-1.4	-0.7	-0.5
Hypertension (Self-reported)	0.6	1.6	2.2	-0.5	-1.4	-1.3	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.4	-0.3	-0.1	-0.2
Illnesses of father: Heart disease	0.1	0.1	0.3	-0.6	-0.1	0.4	0.1
Illnesses of siblings: Diabetes	0.7	0.8	1.9	0.0	0.7	-1.0	-1.4
Smoking status: Previous	5.5	8.2	15.8	1.5	0.6	-4.0	-3.8
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.7	-0.0	0.1	1.3	1.3
Whole body fat-free mass	0.6	3.2	5.1	0.1	-2.3	-2.2	-1.7
Leg fat-free mass (right)	0.6	3.4	5.4	0.0	-2.3	-2.3	-1.7
Arm fat percentage (left)	1.1	4.5	7.3	-1.0	-1.7	-2.7	-2.6
Average weekly red wine intake	0.4	0.7	0.9	0.6	0.7	-0.9	-1.0
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.6	0.3	-1.1	-1.6	-1.6
Mood swings	5.4	9.8	19.3	-0.1	-0.9	-4.4	-4.4
Loneliness, isolation	2.2	3.0	5.4	-0.7	-1.5	-2.3	-2.0
Long-standing illness, disability or infirmity	0.7	1.1	4.0	-2.0	0.4	-0.4	-0.1
Ever had bowel cancer screening	0.5	0.6	1.3	-0.1	-0.4	-1.1	-1.0
Diabetes diagnosed by doctor	0.4	0.7	1.4	1.2	0.9	-0.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.6	0.8	-1.3	-0.4	0.1
Friendships satisfaction	2.4	3.0	5.5	1.8	0.2	1.9	2.3
Qualifications: nursing, teaching	1.7	2.7	4.0	0.8	1.4	2.0	2.0
Commuting to job workplace: Walk	0.3	0.4	0.8	0.5	0.5	0.9	0.5
Eye problems/disorders: Cataract	1.3	1.5	3.7	1.3	-1.9	-0.8	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	2.6	0.8	0.0	-1.6	-1.6
Medication for cholesterol	2.1	3.1	4.0	1.7	2.0	1.8	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.7	-0.8	-0.0	-1.3	-0.4
Back pain experienced in last month	1.5	2.2	4.6	0.1	-0.6	-2.0	-2.1
Mineral and other dietary supplements	0.7	1.0	3.1	0.1	1.8	0.9	0.1
Breast cancer (self-reported)	0.7	0.9	2.4	0.4	-0.1	0.9	1.6
Asthma (self-reported)	0.2	0.4	0.7	0.4	0.2	-0.9	-0.8
Osteoporosis (self-reported)	1.2	1.5	2.7	1.1	0.2	1.7	1.5
Osteoarthritis (self-reported)	0.1	0.1	0.1	-0.4	0.3	-0.3	-0.2
Medication: Aspirin	0.7	0.9	1.6	0.9	0.4	-1.3	-1.1
Medication: Gliclazide	0.1	0.1	0.2	0.2	-0.1	-0.1	-0.5
Illnesses of father: None of the above (group 1)	0.8	1.0	1.8	-0.8	0.4	-1.4	-1.1
Smoking status: Current	0.1	0.1	0.3	0.3	0.2	0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	2.8	0.8	0.7	1.6	1.7
Whole body water mass	0.5	3.1	4.9	0.0	-2.2	-2.2	-1.6
Leg predicted mass (right)	0.7	3.6	5.9	-0.1	-2.4	-2.3	-1.8
Arm fat mass (left)	1.1	4.4	8.0	-0.7	-1.6	-2.8	-2.6
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	-0.1	-0.2	-0.5	-0.7
Average weekly champagne plus white wine intake	0.7	1.0	3.0	1.7	-0.9	-0.2	-0.4
Miserableness	0.7	1.3	1.8	-1.2	0.6	-1.2	-1.4
Guilty feelings	0.2	0.4	0.7	-0.9	-0.7	0.2	-0.4
Wears glasses or contact lenses	0.4	0.5	1.1	-0.0	0.6	-1.0	-0.8
Ever taken oral contraceptive pill	2.4	2.7	4.7	1.1	1.2	2.2	1.9
Hearing aid user	0.8	0.9	3.2	-1.8	0.7	-0.2	0.0
Mother’s age at death	0.1	0.1	0.1	-0.3	0.2	0.4	0.1
Financial situation satisfaction	0.1	0.1	0.2	0.4	0.4	-0.2	0.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.3	-0.1	0.9	1.1	1.0
Commuting to job workplace: Public transport	0.5	0.6	2.0	-0.2	-1.4	0.4	0.3
Eye problems/disorders: Glaucoma	0.8	1.0	3.3	-0.3	-1.8	-0.6	-0.5
Medication: Blood pressure	1.3	2.4	4.3	-0.8	-2.1	-1.6	-1.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.6	-0.2	0.6	-0.6	-1.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	-0.4	-0.5	-0.2	0.1
High cholesterol (Self-reported)	0.0	0.0	0.1	0.0	0.2	-0.1	-0.3
Medication: Bendroflumethiazide	0.2	0.4	1.1	0.2	-1.0	-0.5	-0.3
Medication: Paracetamol	0.9	1.4	2.3	1.5	0.2	-1.2	-1.4
Medication: Lisinopril	0.9	1.2	2.9	-1.3	-1.7	0.3	0.2
Medication: Atorvastatin	0.4	0.5	0.9	-0.9	0.0	-0.6	-0.9
Illnesses of father: High blood pressure	0.4	0.6	0.8	0.8	-0.1	0.9	0.9
Alcohol drinker status: Never	0.6	0.7	1.2	-0.9	1.1	0.7	0.6
Ever smoked	4.7	8.2	18.7	0.1	-0.2	-3.7	-4.3
Basal metabolic rate	0.7	3.8	6.4	-0.0	-2.2	-2.5	-2.0
Leg fat percentage (left)	1.0	3.8	6.5	-0.8	-1.3	-2.5	-2.5
Arm fat-free mass (left)	0.5	2.7	4.5	-0.2	-1.9	-2.1	-1.7
Number of operations (self-reported)	0.7	1.0	3.3	-1.8	0.4	-0.2	-0.6
Average weekly beer plus cider intake	1.8	2.6	5.6	0.7	-0.9	-2.4	-1.8
Irritability	1.2	2.0	3.9	-0.5	-0.8	-2.0	-1.7
Risk taking	0.1	0.1	0.3	-0.6	0.3	-0.2	-0.1
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.9	0.2	-0.7	0.9	0.9
Fractured/broken bones in last 5 years	1.1	1.4	3.0	-0.7	-1.7	-0.9	-1.0
Age started oral contraceptive pill	0.8	1.0	3.3	1.8	0.6	-0.0	0.4
Diastolic blood pressure, automated reading	0.6	2.0	3.9	-0.7	-0.8	-1.7	-2.0
Ever depressed for a whole week	1.5	1.8	6.4	0.4	2.5	0.5	0.7
Unable to work because of sickness or disability	0.3	0.4	0.9	-0.8	1.0	0.0	-0.2
Commuting to job workplace: Cycle	1.6	1.9	2.9	-1.4	0.9	1.7	1.4
Myopia	1.5	2.2	4.7	0.7	-0.7	1.8	2.2
Vascular/heart problems diagnosed by doctor	0.6	1.7	2.2	1.4	0.8	1.4	1.5
Cholesterol lowering medication	1.2	1.8	3.1	-0.8	-0.7	-1.7	-1.8
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.2	-0.7	-0.6	-1.2	-1.5
Pain experienced in last month	0.8	1.3	2.5	-0.4	1.1	1.6	1.3
Supplements: Calcium	0.6	0.6	1.5	1.2	0.8	0.2	0.6
Basal cell carcinoma (self-reported)	1.3	1.6	4.8	2.2	0.0	0.8	1.0
Heart attack/myocardial infarction (self-reported)	1.2	1.5	2.7	-0.4	-1.4	-1.6	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.7	0.7	0.3	0.3	0.8
Heart disease (siblings)	0.5	0.6	1.4	1.2	-1.0	0.0	0.4
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.2	0.3	-0.6	-0.1
Pack years of smoking	0.9	1.3	4.6	0.0	-2.1	-0.7	-0.5
Impedance of whole body	0.5	2.5	6.6	-0.5	2.6	1.4	1.1
Leg fat mass (left)	1.1	4.3	7.1	-0.5	-1.9	-2.7	-2.5
Arm predicted mass (left)	0.4	2.3	4.1	0.4	-1.6	-2.0	-1.5