TWAS hub - FXYD7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0511	0.0113	2.4e-09	0.046	0.043	0.056	0.052	0.052	1.1e-14	4.4e-14	9.2e-18	1.7e-16	1.9e-16
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0421	0.0185	8.6e-04	0.021	0.029	0.012	NA	0.015	1.6e-03	2.7e-04	1.4e-02	NA	6.5e-03
3	TCGA	Lung Adenocarcinoma	0.0322	0.0194	7.9e-03	-0.002	0.002	-0.001	NA	-0.002	9.1e-01	1.5e-01	5.3e-01	NA	6.2e-01
4	TCGA	Thyroid Carcinoma	0.0480	0.0290	4.7e-03	0.002	0.006	0.001	NA	-0.002	1.9e-01	7.9e-02	2.2e-01	NA	7.3e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Mother’s age at death	6.2	7.8	12.1	-3.1	-3.5	-2.5	-1.8
Osteoporosis (self-reported)	4.6	5.7	9.7	-2.7	-2.3	0.6	-3.1
Medication: Atenolol	3.9	4.9	7.6	2.8	2.6	1.6	1.6
Wheeze or whistling in the chest in last year	3.4	6.1	11.1	-3.3	-2.6	0.2	-2.6
Blood Platelet Count	3.2	36.7	61.3	6.0	7.8	6.9	1.3
Allergy or Eczema	3.2	8.3	13.5	-3.7	-3.6	-0.5	-2.6
Financial situation satisfaction	3.2	3.9	6.4	-2.5	-2.2	-1.2	-1.7
Hair/balding pattern: Pattern 3	3.1	4.7	7.5	2.4	2.7	1.9	1.3
Prospective memory result	3.1	3.8	8.8	-2.0	-1.2	1.0	-3.0
Hearing aid user	3.0	3.4	6.0	2.2	2.4	1.6	0.5
Hypothyroidism (self reported)	2.7	6.1	15.2	3.9	2.3	-0.6	1.9
Medication: Ventolin 100micrograms inhaler	2.7	3.5	6.5	-2.6	-1.1	1.6	-1.9
Diverticular disease/diverticulitis (self-reported)	2.6	3.0	11.4	-0.5	0.3	3.4	-0.6
Hayfever/allergic rhinitis (self-reported)	2.5	3.4	5.7	-2.3	-2.4	-0.4	-1.5
Hayfever, allergic rhinitis or eczema	2.4	5.1	8.8	-2.7	-3.0	-0.7	-1.9
Medication: Gliclazide	2.4	2.7	4.6	1.7	1.6	0.9	2.1
Pain type(s) experienced in last month: Hip pain	2.4	3.0	6.3	1.5	1.7	-0.7	2.5
Basal cell carcinoma (self-reported)	2.4	2.8	4.7	-2.0	-2.2	-1.1	-1.2
Type 2 Diabetes (T2D) (2018)	2.2	4.1	5.5	1.7	2.2	1.8	2.4
Mood swings	2.2	3.9	11.8	-0.1	1.9	3.4	0.3
Alcohol drinker status: Previous	2.1	2.4	3.5	1.7	1.7	0.6	1.9
Osteoarthritis (self-reported)	2.0	2.6	4.5	2.1	1.7	1.4	1.0
Ever taken oral contraceptive pill	2.0	2.2	3.9	-0.6	-1.6	-1.5	-2.0
Medication: Omeprazole	1.9	2.3	4.7	1.0	2.2	1.8	0.4
LDL Cholesterol	1.8	2.8	5.9	1.7	1.4	-0.7	2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.2	3.3	-1.5	-1.8	-0.7	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	5.8	0.6	1.8	1.3	2.4
Irritable Bowel Disease (IBD)	1.7	4.0	10.0	-0.1	2.0	3.2	1.4
Ovarian Cancer	1.7	2.2	3.9	-0.9	-2.0	-1.9	-0.6
Ulcerative Colitis	1.7	2.5	6.8	0.2	1.5	2.6	1.0
Relative age voice broke	1.7	2.6	3.7	-1.9	-1.9	-1.6	-0.8
Alzheimer’s Disease (in mother)	1.6	1.9	4.1	-0.1	1.3	2.0	1.3
Medication: Metformin	1.6	2.2	4.3	1.3	1.6	0.5	2.1
Diabetes diagnosed by doctor	1.6	2.7	3.7	1.6	1.8	0.9	1.9
Miserableness	1.6	2.8	3.6	1.6	1.9	1.5	1.7
Average weekly beer plus cider intake	1.6	2.4	6.3	0.5	1.5	2.5	0.9
Schizophrenia vs Biploar Disorder	1.5	1.9	2.9	1.5	0.7	-1.4	1.7
Lupus	1.5	2.2	4.6	-2.1	-1.5	0.9	-1.1
Diabetes (self-reported)	1.5	2.2	3.6	1.7	1.5	0.4	1.9
Medication: Ramipril	1.5	2.0	3.4	-1.8	-1.7	-0.8	-0.9
Chronic bronchitis/emphysema (mother)	1.5	1.7	3.0	-1.4	-1.7	-0.7	-1.2
Medication for pain relief, constipation, heartburn	1.5	2.5	3.7	-1.5	-1.9	-1.9	-0.8
Commuting to job workplace: Car/motor vehicle	1.5	1.7	5.0	-0.7	0.5	2.2	0.9
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	3.5	0.8	1.9	1.8	0.3
Mean Putamen Volume	1.4	1.6	2.0	1.4	1.3	0.8	1.4
Angina	1.4	1.9	3.5	1.9	1.7	0.5	1.0
Depression (self-reported)	1.3	1.6	2.3	-1.5	-1.4	-0.3	-1.5
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	6.1	2.5	1.2	-1.2	1.1
Shortness of breath walking on level ground	1.3	1.6	6.0	-0.1	0.6	2.4	0.0
Neck or shoulder pain in last month	1.3	1.9	3.5	1.1	1.6	0.2	1.9
Commuting to job workplace: Walk	1.3	1.4	3.4	-0.8	-1.1	-1.9	-0.7
Medication: Aspirin	1.3	1.8	2.5	1.0	1.6	1.5	1.2
Neuroticism (2016)	1.2	1.8	4.9	-0.4	1.4	2.2	-0.1
Financial difficulties in last 2 years	1.2	1.6	2.2	-1.5	-1.5	-0.5	-1.3
Comparative body size at age 10	1.2	3.3	5.2	-1.6	-1.9	-2.3	-1.4
Emphysema/chronic bronchitis	1.2	1.4	2.5	1.2	1.6	0.5	1.2
Angina (self-reported)	1.2	1.6	2.9	1.7	1.5	0.4	1.0
Medication: Ibuprofen	1.2	1.4	3.2	1.8	1.4	0.7	0.1
Myopia	1.2	1.8	5.9	0.5	-1.0	-2.4	-0.2
Diabetes (father)	1.1	1.4	2.3	1.5	1.2	0.2	1.3
Nervous feelings	1.1	2.1	3.5	1.0	1.9	1.6	1.1
Time employed in main current job	1.1	1.3	3.0	-1.7	-0.4	0.2	-1.4
Glaucoma (self-reported)	1.1	1.3	2.5	1.3	1.6	1.0	0.5
Illnesses of father: Heart disease	1.1	1.6	2.3	1.5	1.4	-0.0	1.4
Leg fat percentage (left)	1.1	3.8	8.0	-1.9	-0.6	1.8	-2.8
Depressed Affect (Nagel 2018)	1.0	2.1	3.9	0.6	2.0	1.5	1.4
Neuroticism (Nagel 2018)	1.0	2.4	5.2	0.8	2.3	0.8	1.8
Alzheimer’s Disease (in father)	1.0	1.1	3.5	0.5	-0.7	-0.1	-1.9
Ulcerative Colitis (UC)	1.0	1.9	5.8	-0.4	0.9	2.4	0.9
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.7	1.3	0.4	-0.9	1.3
Maternal smoking around birth	1.0	1.4	2.4	1.2	1.6	1.2	0.7
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.4	1.1	0.9	0.3	1.6
Supplements: Glucosamine	1.0	1.3	3.7	0.7	0.4	-0.9	1.9
Allergy	1.0	2.2	3.8	2.0	1.7	-0.2	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.6	1.6	1.3	0.8	-0.3
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	5.3	0.8	0.4	-2.3	0.4
Triglycerides	0.9	1.5	3.7	0.8	0.1	-1.9	1.3
Blood Red Count	0.9	8.9	18.4	-3.1	-2.7	0.2	-4.3
Number of treatments/medications taken	0.9	1.6	3.1	-0.7	0.1	1.8	-1.6
Trunk fat percentage	0.9	3.5	7.5	-2.0	-1.0	1.3	-2.7
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	2.6	1.2	1.2	0.4	1.6
Birth weight of first child	0.9	1.6	5.1	-0.7	-0.1	2.3	-0.7
Body fat percentage	0.9	3.6	7.9	-1.9	-0.8	1.4	-2.8
Leg fat percentage (right)	0.9	3.2	6.8	-1.9	-0.5	1.5	-2.6
Number of children fathered	0.9	1.0	1.9	1.1	1.0	0.5	1.4
Back pain experienced in last month	0.9	1.4	2.6	0.2	1.6	1.1	1.2
Medication: Blood pressure	0.9	1.6	4.3	-1.0	0.3	2.1	-1.0
Crohns Disease (2017)	0.8	1.8	3.8	0.1	1.6	2.0	0.9
Smoking Status	0.8	1.9	4.0	0.5	2.0	1.6	0.9
Average weekly spirits intake	0.8	0.9	2.0	-1.4	-1.0	-0.2	-0.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.0	-0.1	-1.0	-1.4	-1.1
Noisy workplace	0.8	1.0	1.9	-0.6	0.1	1.3	-1.4
Asthma	0.8	1.7	2.3	-1.5	-1.1	1.2	-1.2
Arm fat mass (right)	0.8	3.3	4.4	-2.0	-0.4	2.1	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.0	-0.7	-1.0	-1.4	-0.2
Health satisfaction	0.8	1.0	2.5	0.4	1.1	1.6	0.5
Chest pain or discomfort	0.8	1.1	2.0	-0.5	-1.0	-1.4	-1.1
Arm fat percentage (left)	0.8	3.0	5.3	-2.0	-0.6	1.6	-2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.1	-0.5	-1.5	0.0	-1.1
Asthma (self-reported)	0.8	1.5	2.4	-1.5	-1.1	1.1	-1.2
Arm fat mass (left)	0.8	3.2	4.9	-2.0	-0.5	1.9	-2.2
Average weekly champagne plus white wine intake	0.8	1.1	2.4	-1.5	-1.2	0.1	-0.7
Guilty feelings	0.8	1.2	2.8	0.5	0.3	-1.7	1.3
Diastolic blood pressure, automated reading	0.8	2.3	4.1	-1.3	0.7	2.0	-1.7
Reaction Time	0.7	1.4	2.1	-1.5	-1.2	-1.0	-1.0
Age at First Birth	0.7	1.0	3.4	-0.5	-0.5	0.2	-1.8
Crohns Disease (2012)	0.7	1.2	2.1	0.6	1.3	1.5	0.8
Respiratory disease	0.7	1.6	3.3	-1.8	-1.4	0.4	-0.9
High blood pressure (mother)	0.7	1.0	1.8	0.4	1.3	0.6	1.4
Trunk fat mass	0.7	3.2	6.1	-1.8	-0.7	1.7	-2.5
Waist circumference	0.7	2.7	4.2	-2.0	-0.5	1.8	-1.8
Mouth/teeth dental problems: Dentures	0.7	1.2	4.1	-0.8	0.3	2.0	-0.4
Eye problems/disorders: None of the above	0.7	0.8	2.0	-0.9	0.4	1.4	-0.6
Whole body fat mass	0.7	3.0	5.5	-1.9	-0.6	1.7	-2.3
Alcohol intake frequency.	0.7	1.7	3.1	1.8	1.4	0.3	1.3
Number of full sisters	0.7	0.9	1.5	1.2	0.7	-0.4	1.2
Age at last live birth	0.7	1.0	2.9	0.6	-0.7	-1.7	-0.1
Family relationship satisfaction	0.7	0.8	2.4	-1.5	-0.4	-0.2	-0.8
Eye problems/disorders: Glaucoma	0.7	0.8	1.4	0.9	1.2	0.5	0.8
Medication: Paracetamol	0.7	1.0	2.3	0.8	1.0	1.5	0.4
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.7	1.1	0.8	0.3	1.3
Heart disease (siblings)	0.7	0.8	1.3	1.0	1.1	0.5	0.9
Leg fat mass (left)	0.7	2.9	4.8	-1.8	-0.3	1.9	-2.2
Worry (Nagel 2018)	0.6	1.3	2.8	1.0	1.7	0.3	1.2
Prostate Cancer	0.6	0.9	1.7	-0.6	-0.8	-1.0	-1.3
Blood White Count	0.6	4.6	7.7	1.8	2.5	1.0	2.8
Supplements: Zinc	0.6	0.6	1.2	-0.2	-1.1	-0.8	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.4	0.7	0.8	1.2	-0.9
Multivitamins +/- minerals	0.6	0.8	1.4	1.2	0.6	-0.7	1.0
Body mass index (BMI)	0.6	2.5	4.3	-1.6	-0.2	1.8	-2.1
Hearing difficulty/problems with background noise	0.6	1.0	1.7	1.3	0.8	-0.3	1.3
Pain all over the body in last month	0.6	0.6	1.4	-0.7	-0.2	1.2	-0.8
Arm fat percentage (right)	0.6	2.6	3.8	-1.8	-0.2	2.0	-1.8
Falls in the last year	0.6	0.7	1.0	1.0	0.6	1.0	-0.8
Number of live births	0.6	0.8	2.1	-0.5	-0.8	-1.5	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.7	0.3	0.1	-1.6	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.6	-1.2	-0.9	0.8	-0.9
Pulse wave reflection index	0.6	0.7	1.2	-1.1	-0.1	1.1	-0.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.7	-1.3	-1.0	-0.0	-0.8
Medication: Paracetamol	0.6	1.0	3.1	0.4	0.8	1.8	0.2
Forced vital capacity (FVC), Best measure	0.6	2.2	4.5	1.6	1.0	-0.7	2.1
Number of full brothers	0.6	0.8	1.6	1.3	0.8	0.7	-0.6
Heart disease (mother)	0.6	0.7	2.5	0.2	-0.1	-0.3	1.6
Leg fat mass (right)	0.6	2.5	4.1	-1.7	-0.3	1.7	-2.0
Medication: Aspirin	0.6	0.8	1.2	0.4	0.9	1.1	1.0
Eye problems/disorders: Cataract	0.6	0.7	1.6	-0.2	-1.0	-1.2	0.4
Cholesterol lowering medication	0.6	0.9	1.7	0.7	1.3	0.3	1.1
Bipolar Disorder (2018)	0.5	0.9	2.0	-1.4	-1.0	-0.5	-0.3
Breast Cancer	0.5	1.3	2.8	0.7	-0.8	-1.7	-1.1
Body Mass Index (BMI) (2010)	0.5	0.7	1.1	-0.5	-0.8	-1.0	-1.1
Fasting Glucose	0.5	0.6	1.8	0.6	0.6	-0.2	1.4
HDL Cholesterol	0.5	0.8	1.7	0.2	1.2	1.3	-0.0
BMI	0.5	2.7	6.3	-1.5	-0.1	2.5	-1.5
Age when periods started (menarche)	0.5	1.3	2.4	1.6	1.2	0.9	0.7
Medication: Levothyroxine sodium	0.5	0.8	1.8	1.3	0.7	-1.0	0.4
Chronic bronchitis/emphysema (father)	0.5	0.6	1.2	0.3	-0.4	-1.1	0.9
Past tobacco smoking	0.5	0.9	2.1	1.1	-0.7	-1.4	0.1
Had menopause	0.5	0.7	1.0	1.0	0.5	-0.8	0.9
Mouth/teeth dental problems	0.5	0.8	1.8	1.1	0.0	-1.4	0.1
Medication: Simvastatin	0.5	0.7	1.3	1.1	1.1	0.4	0.5
Hip circumference	0.5	2.0	3.6	-1.5	-0.3	1.4	-1.9
Pulse wave Arterial Stiffness index	0.5	0.6	1.5	-1.2	-0.7	-0.4	-0.0
Exposure to tobacco smoke at home	0.5	0.5	2.0	-0.2	-0.1	0.2	1.4
Tense / ‘highly strung’	0.5	0.9	2.9	-0.4	0.7	1.7	0.0
Ever highly irritable/argumentative for 2 days	0.5	0.7	1.3	0.4	1.1	1.1	0.1
Medication: Amlodipine	0.5	0.7	2.4	-0.0	0.3	1.6	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.6	-1.0	-1.3	-0.5	-0.2
Overall health rating	0.5	1.2	1.6	1.2	1.3	0.6	1.2
Had major operations	0.5	0.5	0.8	0.5	0.9	0.8	0.7
Commuting to job workplace: Public transport	0.5	0.6	2.2	-0.1	-0.1	-1.5	-0.2
High cholesterol (Self-reported)	0.5	0.9	1.8	1.1	0.7	-0.5	1.3
Medication: Lisinopril	0.5	0.6	1.5	1.2	1.0	0.1	-0.2
Ever smoked	0.5	0.9	1.9	-1.4	0.4	1.0	-0.6
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.1	-0.7	-1.0	-0.3	-0.7
Fractured/broken bones in last 5 years	0.5	0.6	1.2	-0.8	0.1	1.1	-0.8
Pain experienced in last month	0.5	0.8	1.4	-0.6	-1.2	-0.9	-0.8
Supplements: Calcium	0.5	0.6	0.9	-0.7	-0.9	0.4	-0.9
Depression (Nagel 2018)	0.4	0.6	1.1	1.0	1.1	0.5	0.1
Alzheimer’s Disease (including proxy)	0.4	0.5	0.7	0.7	0.6	0.7	0.8
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.7	1.3	0.0	0.0	0.0
Neuroticism	0.4	1.1	2.5	0.1	1.6	0.2	1.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.4	-0.7	-0.5	0.5	-1.2
Systolic blood pressure, automated reading	0.4	1.1	2.5	-1.1	0.2	1.6	-0.7
Taking other prescription medications	0.4	0.6	1.3	-0.0	0.1	1.1	-1.0
Qualifications: CSEs or equivalent	0.4	0.6	1.6	0.5	1.3	0.7	-0.0
Serious illness, injury or assault to yourself	0.4	0.5	1.9	1.4	0.2	-0.3	0.2
Alcohol usually taken with meals	0.4	0.6	0.9	-0.6	-0.9	-0.7	-0.9
Forced vital capacity (FVC)	0.4	1.5	3.2	1.1	0.5	-1.1	1.8
Weight	0.4	2.2	4.0	-1.5	-0.2	2.0	-1.5
Alcohol intake versus 10 years previously	0.4	0.5	0.6	0.7	0.7	0.7	0.8
Medication: Lansoprazole	0.4	0.5	1.3	-0.4	-1.1	-0.8	-0.1
Impedance of arm (left)	0.4	1.7	3.3	-0.6	-1.7	-1.8	-0.7
Gout (self-reported)	0.4	0.6	0.8	-0.9	-0.5	0.8	0.8
Pulse wave peak to peak time	0.4	0.5	1.6	1.3	0.5	0.2	0.2
Medication: Seretide 50 evohaler	0.4	0.5	1.5	0.4	-0.5	-1.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.9	-0.9	-0.3	-0.8	0.4
Medication for cholesterol	0.4	0.6	1.6	0.1	-0.8	-1.3	0.0
Mineral and other dietary supplements	0.4	0.5	0.8	-0.9	-0.5	0.4	-0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	-1.0	-0.7	0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.5	1.2	0.7	-0.4	1.2
Wears glasses or contact lenses	0.4	0.5	1.0	-1.0	-0.5	0.4	-0.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.7	-0.6	-0.8	-0.9	-0.4
Alcohol drinker status: Never	0.4	0.5	1.3	-0.3	-0.7	-1.1	-0.5
Commuting to job workplace: Cycle	0.4	0.4	1.3	1.1	0.6	0.1	0.1
Relative age of first facial hair	0.3	0.7	1.2	-0.8	-0.8	-1.1	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.4	0.6	0.4	-0.6	-0.7
Medication for hormone replacement therapy	0.3	0.3	0.9	-0.2	-0.4	-0.1	-1.0
Vitamin and mineral supplements	0.3	0.4	1.2	-0.4	0.4	1.1	-0.3
Medication: Co-codamol	0.3	0.4	0.7	0.8	0.8	0.4	0.1
Fed-up feelings	0.3	0.6	1.1	-0.2	0.9	1.1	0.5
Number of incorrect matches in round	0.3	0.6	1.0	-1.0	-0.2	0.6	-0.9
Father’s age at death	0.3	0.4	0.7	-0.8	-0.2	0.4	-0.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.2	0.5	-0.1	-1.2	1.5
Pulse rate	0.3	0.5	1.7	0.0	-0.6	-0.2	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.2	0.7	-0.1	-1.2	1.5
Breastfed as a baby	0.3	0.4	1.2	-0.6	-0.3	-1.1	-0.3
Hair/balding pattern: Pattern 4	0.3	0.7	1.2	1.1	0.8	-0.0	1.1
Peak expiratory flow (PEF)	0.3	0.7	1.2	-1.0	-1.1	-0.7	0.0
Loud music exposure frequency	0.3	0.3	0.5	0.5	0.6	0.7	-0.1
Blood clot in the leg (DVT)	0.3	0.4	0.8	0.7	0.4	0.2	0.9
Worry too long after embarrassment	0.3	0.6	1.9	-0.5	-0.3	-1.4	-0.3
Migraine (self-reported)	0.3	0.4	1.0	-0.5	-0.7	-0.2	-1.0
Mean time to correctly identify matches	0.3	0.5	1.0	-1.0	-0.7	-0.6	-0.7
Leg pain on walking	0.3	0.4	1.1	1.0	0.5	0.3	0.4
Supplements: Vitamin C	0.3	0.4	0.9	0.0	-0.7	-0.9	-0.3
Smoking status: Previous	0.3	0.4	1.0	-0.7	0.5	1.0	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.0	0.2	0.5	0.0	1.0
Breast cancer (self-reported)	0.3	0.3	0.9	0.4	-0.3	-1.0	0.2
Medication: Atorvastatin	0.3	0.4	1.1	-0.3	0.2	-0.6	1.1
Illnesses of father: High blood pressure	0.3	0.4	0.6	0.3	0.6	0.8	0.6
Irritability	0.3	0.5	1.3	-0.6	0.5	1.2	0.2
Impedance of whole body	0.3	1.4	2.7	-0.3	-1.4	-1.6	-0.8
Bipolar Disorder or Schizophrenia	0.2	0.4	1.0	-1.0	-0.8	-0.3	0.0
HbA1C	0.2	0.2	0.5	0.1	-0.7	-0.4	-0.4
Schizophrenia (2014)	0.2	0.4	0.8	-0.8	-0.9	-0.4	-0.2
Blood Eosinophil Count	0.2	1.7	4.0	-0.6	-0.4	2.0	-1.5
Lung FEV1/FVC ratio	0.2	0.9	1.3	-1.1	-1.0	-0.6	-1.1
Lung FVC	0.2	0.9	2.5	0.8	0.3	-1.6	0.7
Chronotype (morning person)	0.2	0.5	0.9	0.9	0.6	0.3	0.7
Sensitivity / hurt feelings	0.2	0.4	0.7	-0.7	0.7	0.0	0.9
Diabetes (mother)	0.2	0.2	0.4	0.6	0.2	0.6	0.1
Severe depression (siblings)	0.2	0.2	0.4	-0.2	-0.4	-0.7	-0.5
Impedance of leg (right)	0.2	0.7	2.4	0.3	-0.7	-1.5	-0.0
Leg fat-free mass (left)	0.2	1.0	3.2	-0.8	0.4	1.8	-0.3
Average weekly fortified wine intake	0.2	0.2	0.4	-0.5	-0.2	0.7	0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.7	0.5	-0.3	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	-0.5	-0.1	1.0	-0.7
High blood pressure	0.2	0.5	0.9	-0.9	0.1	1.0	-0.5
Stomach or abdominal pain in last month	0.2	0.3	0.6	0.8	0.1	0.1	0.7
Impedance of leg (left)	0.2	0.8	2.0	0.1	-1.0	-1.4	-0.5
Leg predicted mass (left)	0.2	1.0	3.3	-0.7	0.4	1.8	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	-0.6	-0.5	-0.2	-0.7
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	-0.1	-0.3	-0.9	-0.5
Had other major operations	0.2	0.3	0.8	-0.9	-0.3	-0.4	0.1
Qualifications: None of the above	0.2	0.5	1.4	0.5	0.4	1.2	0.4
Fluid intelligence score	0.2	0.4	1.1	-0.1	-0.7	-1.1	-0.2
Trunk fat-free mass	0.2	1.0	3.2	-0.3	0.7	1.8	0.2
Medication: Cholesterol lowering	0.2	0.4	0.9	0.9	0.2	-0.7	0.4
Lung cancer (father)	0.2	0.2	0.4	0.6	0.3	0.3	0.6
Illnesses of mother	0.2	0.2	0.6	0.4	0.2	0.4	-0.8
Headache pain in last month	0.2	0.3	0.6	-0.3	-0.8	-0.6	-0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	0.1	0.6	1.0	0.1
Birth weight	0.2	0.4	0.8	-0.8	0.1	0.4	-0.9
Arm fat-free mass (right)	0.2	1.1	3.4	-0.5	0.4	1.9	-0.6
Exposure to tobacco smoke outside home	0.2	0.3	0.5	-0.7	-0.6	-0.5	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	0.1	0.6	-0.0	0.6
Medication: Allopurinol	0.2	0.3	0.9	-0.9	-0.4	0.2	0.2
Arm predicted mass (right)	0.2	0.9	2.9	-0.2	0.6	1.7	-0.2
Knee pain experienced in last month	0.2	0.4	0.9	0.9	0.6	0.4	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.9	0.1	-0.0	-0.3	0.9
Illnesses of siblings: Diabetes	0.2	0.2	0.4	-0.4	0.3	0.6	-0.4
Whole body fat-free mass	0.2	1.0	3.3	-0.5	0.5	1.8	-0.1
Leg fat-free mass (right)	0.2	1.0	3.4	-0.7	0.3	1.8	-0.4
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	0.3	0.8	0.4	-0.2
Friendships satisfaction	0.2	0.2	0.6	0.3	-0.1	-0.2	0.8
Whole body water mass	0.2	1.0	3.6	-0.5	0.6	1.9	-0.1
Leg predicted mass (right)	0.2	1.0	3.2	-0.7	0.3	1.8	-0.4
Basal metabolic rate	0.2	1.2	4.1	-0.8	0.4	2.0	-0.4
Arm fat-free mass (left)	0.2	0.9	3.0	-0.6	0.5	1.7	-0.3
Age started oral contraceptive pill	0.2	0.2	0.4	-0.5	-0.6	0.0	-0.5
Unable to work because of sickness or disability	0.2	0.3	0.8	0.3	-0.2	-0.9	-0.4
Arm predicted mass (left)	0.2	1.1	3.5	-0.9	0.2	1.9	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.7	0.3	0.3	0.8	0.2
Major Depression (MDD)	0.1	0.1	0.3	-0.6	0.0	0.0	0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.6	-0.0	0.0	0.7	-0.1
Coronary Artery Disease (CAD)	0.1	0.1	0.4	-0.6	0.0	0.0	0.0
Rheumatoid Arthritis	0.1	0.1	0.5	0.7	0.1	-0.1	-0.3
Height	0.1	2.1	4.0	0.9	1.4	1.4	2.0
Cardiovascular Disease	0.1	0.4	1.0	-1.0	-0.6	-0.1	-0.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.4	0.2	-0.5	0.1
Pack years adult smoking proportion	0.1	0.1	0.4	-0.6	-0.3	-0.3	-0.1
Hand grip strength (right)	0.1	0.3	0.8	0.1	-0.7	-0.9	0.2
Townsend deprivation index at recruitment	0.1	0.2	0.5	-0.0	0.3	0.3	0.7
Current tobacco smoking	0.1	0.1	0.4	0.1	0.3	-0.6	-0.0
Sitting height	0.1	0.7	1.3	0.3	0.4	1.1	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.4	0.1	0.7	-0.3
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	-0.6	0.0	0.4	-0.1
Heart attack	0.1	0.1	0.2	-0.2	0.5	0.1	-0.3
Illnesses of siblings	0.1	0.1	0.4	-0.2	-0.7	-0.3	-0.0
Neuroticism score	0.1	0.3	0.5	-0.7	0.6	0.5	0.2
Impedance of arm (right)	0.1	0.6	1.5	0.1	-0.7	-1.2	0.5
Worrier / anxious feelings	0.1	0.2	0.5	0.3	0.7	-0.3	-0.4
Happiness	0.1	0.2	0.3	-0.5	0.0	0.2	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.6	0.1	0.3	-0.4	0.8
Trunk predicted mass	0.1	0.8	2.8	-0.3	0.6	1.7	0.2
Length of working week for main job	0.1	0.1	0.3	0.2	0.2	0.6	-0.1
High blood pressure (siblings)	0.1	0.1	0.3	-0.4	-0.0	-0.5	0.4
Age at first live birth	0.1	0.3	0.6	0.4	-0.5	-0.8	-0.2
Qualifications: College or University degree	0.1	0.3	0.7	0.0	-0.9	-0.8	0.2
Medication: Blood pressure	0.1	0.1	0.4	0.2	-0.0	-0.6	0.1
Comparative height size at age 10	0.1	0.5	1.4	-0.2	-0.0	1.2	0.6
Suffer from ‘nerves’	0.1	0.1	0.4	0.2	0.6	0.3	-0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.1	0.3	0.4	-0.0
Hypertension (Self-reported)	0.1	0.4	0.9	-0.6	0.3	0.9	-0.4
Average weekly red wine intake	0.1	0.1	0.1	-0.4	0.2	0.3	-0.3
Loneliness, isolation	0.1	0.2	0.5	-0.4	0.4	-0.1	0.7
Long-standing illness, disability or infirmity	0.1	0.1	0.4	0.6	0.2	-0.3	0.2
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	-0.3	0.3	0.5	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	0.3	0.3	-0.3	0.3
Medication: Bendroflumethiazide	0.1	0.1	0.3	-0.1	0.2	0.1	0.5
Risk taking	0.1	0.2	0.4	0.4	0.3	-0.7	-0.2
Ever depressed for a whole week	0.1	0.2	0.3	0.6	0.5	-0.0	0.3
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.8	0.9	0.0	-0.7	0.6
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.2	0.4	0.1	-0.3
Pack years of smoking	0.1	0.1	0.2	-0.5	-0.3	-0.1	0.0
Schizophrenia (2018)	0.0	0.1	0.3	-0.2	-0.1	0.1	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.0	0.1	-0.0	-0.1	-0.2	0.3
Heel T-Score	0.0	0.3	0.9	0.4	0.5	0.9	-0.1
Waist Hip Ratio (WHR)	0.0	0.2	0.7	0.1	0.4	0.8	0.2
Systolic Blood Pressure	0.0	0.2	0.6	-0.8	-0.4	0.0	0.2
Hair Pigment	0.0	0.8	2.1	-1.4	-1.0	-0.2	-0.1
Tanning	0.0	0.2	0.4	0.3	0.2	0.7	-0.2
Hand grip strength (left)	0.0	0.1	0.2	-0.1	-0.1	0.5	0.3
Hearing difficulty/problems: Yes	0.0	0.1	0.2	0.1	0.4	0.2	0.1
Standing height	0.0	0.3	0.9	0.2	0.1	0.5	1.0
Pulse rate, automated reading	0.0	0.1	0.1	0.3	-0.0	0.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	0.4	0.3	-0.3	0.2
Ever had bowel cancer screening	0.0	0.0	0.1	-0.2	-0.0	0.3	0.1
Qualifications: nursing, teaching	0.0	0.1	0.1	-0.3	-0.3	-0.1	-0.3
Smoking status: Current	0.0	0.1	0.2	0.1	0.5	-0.2	-0.0
Number of operations (self-reported)	0.0	0.0	0.1	0.1	0.3	0.1	0.2

Hub : Genes

FXYD7

Models

Trait associations