TWAS hub - G3BP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0520	0.0240	7.5e-03	0.023	0.024	0.006	0.027	0.014	7.6e-04	5.1e-04	4.9e-02	2.4e-04	7.5e-03
2	GTEx	Liver	0.3490	0.1040	2.4e-03	0.049	NA	0.010	NA	0.049	1.7e-02	NA	1.7e-01	NA	1.7e-02
3	ROSMAP	Brain Pre-frontal Cortex	0.1050	0.0297	1.7e-06	0.019	0.042	0.039	0.041	0.037	1.4e-03	3.6e-06	7.2e-06	4.7e-06	1.5e-05
4	TCGA	Brain Lower Grade Glioma	0.0172	0.0123	5.8e-03	0.013	0.016	0.010	NA	0.012	1.1e-02	5.4e-03	2.5e-02	NA	1.3e-02
5	TCGA	Prostate Adenocarcinoma	0.0584	0.0346	6.6e-04	0.038	0.030	0.027	NA	0.032	6.6e-05	3.6e-04	7.8e-04	NA	2.6e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Coronary Artery Disease (CAD)	5.6	6.7	14.3	-3.8	-1.8	-2.3	-1.0	-3.1
Mouth/teeth dental problems	4.1	6.2	14.8	-1.9	0.6	-3.8	-2.0	-2.8
Neuroticism (2016)	3.9	5.6	12.1	2.2	3.5	2.6	2.0	0.8
Medication: Seretide 50 evohaler	3.9	4.5	7.9	2.8	1.7	1.9	1.7	2.2
Headache pain in last month	3.8	6.5	13.2	3.6	1.0	2.4	3.6	0.4
Allergy	3.7	8.6	22.2	-2.2	0.2	-4.7	-2.9	-2.8
Hayfever/allergic rhinitis (self-reported)	3.7	4.8	14.3	1.9	-0.1	3.8	1.4	2.1
Mean time to correctly identify matches	3.5	6.8	16.8	-2.6	-0.0	-2.7	-4.1	-1.7
Allergy or Eczema	3.2	8.5	20.7	2.5	0.0	4.5	3.4	1.9
Chronotype (morning person)	3.2	7.4	12.6	-3.5	-0.8	-3.5	-1.1	-3.2
Financial difficulties in last 2 years	3.2	4.3	7.1	2.7	-0.7	2.6	0.6	2.6
Gout (self-reported)	3.1	4.2	8.4	0.9	-1.9	2.9	2.6	-1.2
Hayfever, allergic rhinitis or eczema	3.0	6.5	16.2	2.0	-0.4	4.0	3.0	1.7
Reaction Time	2.8	5.4	16.5	-1.9	0.3	-2.0	-4.1	-1.6
Financial situation satisfaction	2.6	3.2	5.0	2.0	-0.2	2.2	1.6	2.1
Fed-up feelings	2.5	4.5	14.9	3.9	0.4	1.9	1.8	0.8
Wheeze or whistling in the chest in last year	2.5	4.4	8.0	1.9	-2.0	2.8	1.4	2.1
Ever taken oral contraceptive pill	2.5	2.8	4.1	-1.9	0.8	-1.7	-1.7	-2.0
Asthma	2.4	4.7	11.2	2.0	0.2	3.3	1.7	2.3
HbA1C	2.3	2.5	5.5	0.7	-2.1	1.5	2.3	-0.0
Taking other prescription medications	2.3	3.5	6.1	2.3	0.4	2.3	2.5	-0.8
Asthma (self-reported)	2.3	4.6	10.8	1.9	0.3	3.3	1.6	2.4
Respiratory disease	2.2	4.9	12.2	1.6	0.4	3.5	1.5	2.8
Tinnitus: Yes, but not now, but have in the past	2.2	2.4	9.2	1.4	3.0	0.5	0.5	0.4
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.6	4.7	-1.5	-1.1	-2.2	-2.1	0.3
Number of treatments/medications taken	2.1	3.9	12.6	1.6	0.2	1.8	3.6	-0.9
Mouth/teeth dental problems: Loose teeth	2.1	2.5	6.0	1.8	0.8	2.4	1.6	0.4
Miserableness	2.1	3.6	6.1	2.4	1.5	2.5	0.9	1.8
Mouth/teeth dental problems: Bleeding gums	2.0	2.5	6.2	1.6	0.1	2.5	1.9	0.5
Hypothyroidism/myxoedema (self-reported)	2.0	4.0	8.1	2.9	-1.2	1.8	2.6	0.6
Ever had prostate specific antigen (PSA) test	2.0	2.3	10.2	-0.2	3.2	-0.7	-0.4	-0.7
Lung FEV1/FVC ratio	1.9	9.7	28.4	-0.3	5.3	-2.2	-3.9	-0.4
Eye problems/disorders: None of the above	1.9	2.2	7.2	0.4	-1.5	1.3	-0.2	2.7
Chest pain or discomfort	1.9	2.8	5.6	2.2	-0.1	2.4	1.9	0.1
Had menopause	1.8	2.3	6.9	-1.5	0.4	-2.6	-0.7	-1.3
Number of full sisters	1.8	2.2	9.9	0.6	0.2	1.0	3.1	-0.0
Depressed Affect (Nagel 2018)	1.7	3.6	7.8	2.8	2.5	1.6	1.2	0.1
Rheumatoid Arthritis	1.7	2.3	5.7	1.7	1.4	0.4	2.4	-0.9
Medication for hormone replacement therapy	1.7	1.9	5.5	0.8	2.3	0.5	-0.8	1.5
Loud music exposure frequency	1.6	1.7	7.0	-0.7	-2.6	0.6	0.8	0.4
Average weekly champagne plus white wine intake	1.6	2.1	5.6	0.0	1.4	-1.8	-2.4	0.3
Schizophrenia vs Biploar Disorder	1.5	2.0	3.8	1.8	0.5	2.0	0.9	1.4
Average weekly fortified wine intake	1.5	1.8	6.1	1.5	2.5	0.7	0.1	-0.1
Stomach or abdominal pain in last month	1.5	1.9	3.5	1.7	0.4	1.9	0.8	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	7.0	1.5	0.8	2.6	0.2	1.4
Happiness	1.5	1.8	4.5	1.6	-0.1	2.1	1.3	0.5
Exposure to tobacco smoke at home	1.5	1.7	3.2	1.6	0.7	1.8	-0.0	1.5
Medication: Paracetamol	1.5	2.4	3.6	1.4	-1.4	1.4	1.9	1.7
Pack years adult smoking proportion	1.4	2.1	4.4	1.8	-0.6	2.1	1.3	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	3.1	1.8	-1.4	1.6	-0.3	1.3
Medication: Simvastatin	1.4	2.1	5.0	-1.8	-0.1	-1.5	-2.2	0.1
Ever highly irritable/argumentative for 2 days	1.4	1.7	3.7	1.4	-1.2	1.9	1.2	0.2
Birth weight	1.4	3.1	12.3	-1.2	-0.1	-1.2	-3.5	0.0
Medication: Omeprazole	1.4	1.7	3.5	1.5	-0.2	1.5	1.9	-0.5
Supplements: Vitamin C	1.4	1.6	6.4	-0.4	0.2	-1.1	0.5	-2.5
Loneliness, isolation	1.4	2.0	4.2	2.1	1.6	1.6	0.7	0.2
Hypothyroidism (self reported)	1.3	2.9	7.1	2.7	-1.1	0.8	2.3	0.2
Diabetes (mother)	1.3	1.6	3.5	-1.9	-1.7	-0.7	-0.3	-1.1
Alcohol intake versus 10 years previously	1.3	2.0	5.4	-1.7	-2.3	-0.9	-0.6	-0.5
Birth weight of first child	1.3	2.4	3.9	1.3	1.3	1.0	-2.0	1.9
Number of full brothers	1.3	1.6	3.7	1.5	0.3	1.9	1.2	0.8
Medication: Allopurinol	1.3	1.7	4.4	1.0	-0.9	2.1	1.4	-0.4
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.5	1.9	-0.5	0.9	0.1	1.7
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.5	-1.2	-0.1	-1.8	0.1	-1.9
Eye problems/disorders: Cataract	1.3	1.5	2.5	-1.3	0.4	-1.6	-0.9	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	6.1	-0.5	-0.0	-0.1	-2.5	1.0
Osteoporosis (self-reported)	1.3	1.6	3.3	0.3	-0.4	1.8	1.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	3.6	-1.6	1.8	-1.9	-1.0	-1.8
Medication: Paracetamol	1.3	2.1	4.0	1.4	-1.1	1.3	2.0	1.2
Prostate Cancer	1.2	1.7	5.8	0.3	0.3	-2.4	-0.9	-1.3
Mouth/teeth dental problems: Dentures	1.2	2.0	4.8	1.4	-0.3	1.7	-0.1	2.2
Alcohol drinker status: Never	1.2	1.5	5.5	0.3	-0.9	0.6	2.3	-0.7
Pain experienced in last month	1.2	2.0	4.2	-1.8	-0.1	-1.5	-2.1	-0.2
Pack years of smoking	1.2	1.7	4.0	1.6	-0.2	2.0	1.1	1.0
Depression (Nagel 2018)	1.1	1.7	3.8	1.3	1.9	1.5	-0.6	0.7
LDL Cholesterol	1.1	1.8	3.9	1.1	-0.2	1.8	2.0	0.7
High blood pressure (mother)	1.1	1.5	3.2	1.1	-1.8	1.0	-0.7	1.2
Heart attack	1.1	1.4	3.8	-1.1	-1.9	-0.6	-0.3	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	3.0	-1.7	-0.2	-0.1	-1.7	0.5
Depression (self-reported)	1.1	1.3	3.0	0.9	1.7	1.4	-0.1	0.9
Length of working week for main job	1.1	1.2	3.9	2.0	-0.3	0.2	0.3	1.3
Glaucoma (self-reported)	1.1	1.3	4.0	-0.6	0.6	-1.2	-2.0	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	8.9	1.3	-0.2	3.0	0.8	0.0
Ever had bowel cancer screening	1.1	1.3	4.2	-0.7	0.7	-2.1	-0.8	-1.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	3.7	-0.3	-1.1	1.8	1.9	0.5
Breast cancer (self-reported)	1.1	1.3	1.6	-1.3	-1.1	1.1	-0.9	1.3
Number of self-reported non-cancer illnesses	1.1	1.8	3.6	1.8	1.9	1.4	0.3	0.3
Commuting to job workplace: Cycle	1.1	1.3	3.0	-1.5	-0.8	-0.2	0.7	-1.7
Myopia	1.1	1.5	3.1	-0.2	-1.3	0.4	-1.7	1.8
Alzheimer’s Disease (in father)	1.0	1.1	2.2	0.5	-0.1	-1.5	-1.4	-1.0
Bipolar Disorder (2011)	1.0	1.0	2.4	0.9	-0.8	0.0	1.6	-1.0
Mean Putamen Volume	1.0	1.2	2.6	-0.4	1.5	-1.6	-0.6	-0.6
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.6	-1.5	0.1	0.0	-1.6	0.9
Chronic bronchitis/emphysema (father)	1.0	1.2	3.7	0.9	-1.9	0.9	0.5	-0.5
Time employed in main current job	1.0	1.1	2.8	-1.3	-1.7	0.2	-1.0	0.5
Chronic bronchitis/emphysema (mother)	1.0	1.1	3.1	-0.4	-1.8	0.5	0.1	1.4
Long-standing illness, disability or infirmity	1.0	1.5	3.5	1.7	0.7	1.9	0.7	0.6
Mineral and other dietary supplements	1.0	1.3	6.2	-0.4	0.2	-0.0	-2.5	0.3
Medication: Bendroflumethiazide	1.0	1.6	3.8	0.1	1.3	-1.5	0.2	-2.0
Illnesses of father: High blood pressure	1.0	1.3	3.8	1.0	1.2	0.5	1.9	-0.2
Basal cell carcinoma (self-reported)	1.0	1.2	3.5	-1.9	-0.1	-1.4	-0.5	-0.2
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.9	-1.1	-1.7	-0.8	-0.4	-1.3
Lupus	0.9	1.3	5.0	0.3	-0.5	0.7	-2.2	0.9
Sensitivity / hurt feelings	0.9	1.5	3.3	0.1	-1.1	1.2	1.2	-1.8
Multivitamins +/- minerals	0.9	1.2	2.5	-0.7	0.7	-1.3	1.6	-0.8
High blood pressure (siblings)	0.9	1.3	2.4	1.5	-0.6	1.2	1.3	-0.7
Heart disease (mother)	0.9	1.1	3.3	0.3	0.6	-1.3	-1.8	0.5
Illnesses of siblings: Diabetes	0.9	1.1	3.2	1.5	1.8	-0.0	-0.0	-0.2
Mood swings	0.9	1.6	3.0	1.7	1.1	1.5	1.1	0.2
Commuting to job workplace: Public transport	0.9	1.1	3.4	0.1	0.4	-1.1	-1.8	-0.8
Supplements: Fish oil (including cod liver oil)	0.9	1.2	5.3	0.1	0.8	0.1	2.3	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.6	1.6	-0.0	1.3	1.1	-0.2
Alcohol drinker status: Previous	0.9	1.0	2.8	1.2	-0.2	0.9	1.7	-0.2
Neuroticism (Nagel 2018)	0.8	1.9	4.5	1.8	2.1	1.1	0.6	-0.4
Schizophrenia (2018)	0.8	1.6	5.0	-1.1	-0.7	-1.1	-0.4	-2.2
Worry (Nagel 2018)	0.8	1.6	6.0	0.7	2.5	0.7	-0.2	-1.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.9	-1.7	-0.0	-0.1	-1.3	0.0
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.7	1.5	0.7	1.6	-0.0	0.2
Townsend deprivation index at recruitment	0.8	1.1	3.3	0.6	-0.6	0.8	-0.7	1.8
Qualifications: CSEs or equivalent	0.8	1.1	3.7	-1.0	-1.9	0.6	-0.6	0.1
Medication: Levothyroxine sodium	0.8	1.3	2.3	1.5	-1.5	0.9	1.1	0.2
Number of incorrect matches in round	0.8	1.4	2.7	1.6	0.5	0.4	1.6	-1.1
Had other major operations	0.8	1.0	1.9	1.3	0.7	0.8	1.4	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	6.8	-0.8	2.6	0.1	-2.3	-0.5
Medication: Amlodipine	0.8	1.2	2.9	1.7	-0.1	1.5	0.7	-0.6
Number of children fathered	0.8	0.9	4.2	-2.0	-0.6	-0.0	-0.2	0.0
Heart disease (siblings)	0.8	0.9	2.6	0.8	-1.0	0.1	-0.7	1.6
Neuroticism	0.7	1.6	3.0	1.7	1.4	1.6	0.7	0.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.8	0.1	0.5	0.6	0.9	-1.7
Ever had hysterectomy (womb removed)	0.7	0.7	1.6	-1.3	0.1	-1.0	-0.9	-0.5
Hand grip strength (right)	0.7	2.0	6.8	-1.2	0.6	-1.1	-2.6	-0.3
Age when periods started (menarche)	0.7	1.6	4.0	1.2	1.3	2.0	-0.5	0.9
Past tobacco smoking	0.7	1.2	5.2	0.4	2.3	0.4	0.7	0.2
Nervous feelings	0.7	1.3	3.8	0.4	0.4	-0.2	1.6	-2.0
Hair/balding pattern: Pattern 2	0.7	0.9	2.9	-0.6	0.8	-1.7	-0.5	0.3
Neuroticism score	0.7	1.4	2.1	1.3	1.3	1.5	0.9	-0.6
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	7.2	0.0	2.7	0.4	-2.0	-0.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.7	1.5	-0.0	1.6	0.6	-0.6
Exposure to tobacco smoke outside home	0.7	1.0	1.5	1.2	0.8	1.1	0.2	1.2
Alcohol intake frequency.	0.7	1.6	2.6	0.8	-1.1	1.3	1.6	1.4
Age at last live birth	0.7	1.0	3.1	-0.8	-1.8	-0.3	-0.9	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.9	-0.6	-1.7	-0.5	0.6	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.5	1.2	1.1	-0.7	0.5	-0.7
Wears glasses or contact lenses	0.7	0.8	1.9	0.1	1.1	-0.9	-1.4	0.6
Ever smoked	0.7	1.2	4.4	-0.7	-2.1	-0.1	-1.1	0.2
Supplements: Calcium	0.7	0.8	1.2	-0.8	0.4	-1.0	0.8	-1.1
Major Depression (MDD)	0.6	0.7	2.3	-0.1	0.6	1.5	0.3	-0.8
Breast Cancer	0.6	1.3	2.3	0.9	0.2	1.5	1.1	1.5
Body Mass Index (BMI) (2010)	0.6	0.8	2.1	-0.5	0.0	-1.0	-0.8	-1.4
Angina	0.6	0.8	1.8	0.9	-0.8	1.3	1.0	-0.3
Vitamin and mineral supplements	0.6	0.8	3.0	0.2	-0.4	0.5	-1.7	0.8
Medication: Co-codamol	0.6	0.7	1.5	1.2	1.1	0.4	-0.8	0.2
Medication: Atenolol	0.6	0.8	2.4	1.6	0.1	0.8	0.3	0.8
Pain all over the body in last month	0.6	0.7	1.2	1.0	-0.1	1.1	1.0	0.4
Illnesses of siblings	0.6	0.9	3.3	-1.8	-0.2	-0.7	-0.7	0.2
Tense / ‘highly strung’	0.6	1.0	2.9	0.8	1.7	0.4	0.6	-1.0
Pulse wave reflection index	0.6	0.8	2.1	0.3	0.0	0.2	-1.4	1.3
Angina (self-reported)	0.6	0.8	2.2	0.7	-1.0	1.5	0.7	0.0
Medication: Ibuprofen	0.6	0.8	1.5	-0.7	-0.5	-0.8	0.9	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.2	-0.1	-1.0	0.8	0.8	-1.1
Had major operations	0.6	0.7	1.5	-0.6	1.2	-0.4	-1.2	-0.2
Friendships satisfaction	0.6	0.8	2.1	1.0	-0.0	1.4	-0.2	0.8
Osteoarthritis (self-reported)	0.6	0.8	1.6	1.0	1.0	0.7	1.2	0.4
Fractured/broken bones in last 5 years	0.6	0.7	2.1	0.4	0.0	0.1	1.1	-1.4
Unable to work because of sickness or disability	0.6	0.8	2.2	0.8	0.9	1.5	-0.4	-0.2
Bipolar Disorder (2018)	0.5	0.8	1.7	1.2	-0.0	0.9	1.3	-0.4
Alzheimer’s Disease (including proxy)	0.5	0.8	2.2	1.5	-1.2	0.2	-0.2	-0.2
Crohns Disease (2012)	0.5	0.8	2.2	0.4	-0.6	0.5	1.5	-1.1
Fasting Glucose	0.5	0.6	2.1	0.1	-0.2	-0.0	0.9	-1.4
Primary Biliary Cirrhosis	0.5	0.8	1.8	-1.3	-0.3	0.3	0.1	-1.3
Lung FVC	0.5	2.4	9.7	0.1	3.1	-1.2	-0.8	0.7
Hand grip strength (left)	0.5	1.4	3.7	-1.8	0.6	-0.2	-1.9	0.0
Supplements: Zinc	0.5	0.6	2.5	0.2	0.5	-1.6	0.2	-0.1
Medication: Metformin	0.5	0.8	1.9	-1.1	-0.5	-0.7	-1.4	0.1
Diabetes (father)	0.5	0.6	1.6	0.0	-1.3	-0.7	1.0	0.0
Maternal smoking around birth	0.5	0.7	1.2	-0.8	1.1	-0.9	-0.5	-0.7
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.6	1.6	-0.1	0.0	0.1	0.6
Sitting height	0.5	3.5	5.4	-2.2	-1.4	-1.6	-1.6	-2.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.8	0.8	-0.5	1.7	-0.1	0.3
Qualifications: None of the above	0.5	1.1	3.9	-0.0	1.2	-0.4	0.4	2.0
Comparative body size at age 10	0.5	1.5	6.5	-0.6	-0.6	0.1	-2.6	0.4
Pulse wave peak to peak time	0.5	0.6	1.7	-0.6	0.6	-0.1	0.8	-1.3
Shortness of breath walking on level ground	0.5	0.6	1.5	0.6	1.2	0.6	0.9	-0.2
Medication for pain relief, constipation, heartburn	0.5	0.8	2.8	-0.0	1.7	0.4	-0.9	-0.5
Migraine (self-reported)	0.5	0.6	2.4	0.5	0.1	1.6	0.5	-0.2
Smoking status: Previous	0.5	0.8	3.9	-0.2	-2.0	0.1	-0.2	-0.2
Handedness (chirality/laterality): Left-handed	0.5	0.7	1.5	-1.2	-0.5	0.7	1.0	-0.2
Qualifications: nursing, teaching	0.5	0.7	1.3	-1.0	1.1	-0.1	-0.4	1.1
Mother’s age at death	0.5	0.6	1.3	-0.4	1.0	-0.7	0.2	-1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.3	0.5	0.4	0.7	-1.0	1.1
High cholesterol (Self-reported)	0.5	0.9	2.0	1.1	0.9	-0.3	0.5	1.4
Number of operations (self-reported)	0.5	0.8	3.0	-0.4	1.7	0.0	-0.1	-0.8
Age started oral contraceptive pill	0.5	0.7	1.5	-1.2	-0.5	-0.3	-0.5	-1.1
Diastolic blood pressure, automated reading	0.5	1.6	3.0	1.7	-0.3	1.5	1.6	0.5
Bipolar Disorder or Schizophrenia	0.4	0.9	3.8	-0.1	-0.6	-0.3	0.5	-2.0
Ovarian Cancer	0.4	0.5	1.2	0.3	-0.0	-1.1	-0.7	-0.7
Ulcerative Colitis	0.4	0.6	1.5	-1.0	0.7	0.0	-0.0	-1.2
Blood Platelet Count	0.4	4.8	8.4	1.7	-1.1	2.9	2.6	2.1
Waist Hip Ratio (WHR)	0.4	1.7	5.3	-0.2	-2.3	-0.4	0.4	-1.7
Smoking Status	0.4	0.9	2.8	0.6	-1.7	0.5	0.6	-0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.8	0.1	-0.9	1.3	1.2	0.3
Average weekly spirits intake	0.4	0.5	1.2	-1.0	-0.2	0.2	0.7	-1.1
Hearing difficulty/problems: Yes	0.4	0.7	2.0	0.5	0.6	1.4	0.1	0.9
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.1	-0.1	-1.4	0.1	0.6	-0.5
Current tobacco smoking	0.4	0.6	1.6	0.3	-1.3	0.4	1.1	-0.1
Supplements: Glucosamine	0.4	0.5	1.1	0.4	0.2	-0.6	1.0	-1.1
Impedance of leg (left)	0.4	1.9	3.7	1.4	-0.6	1.9	1.5	1.0
Alcohol usually taken with meals	0.4	0.7	1.5	0.6	1.2	-1.0	-0.6	-0.7
Hearing difficulty/problems with background noise	0.4	0.7	1.6	1.3	-0.5	1.2	0.3	0.4
Father’s age at death	0.4	0.6	1.9	-0.0	-0.2	1.0	-0.3	1.4
Hair/balding pattern: Pattern 3	0.4	0.6	1.1	1.1	0.3	1.0	0.9	-0.1
Number of live births	0.4	0.6	1.3	0.9	0.7	0.6	1.1	0.3
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.9	1.0	1.7	0.7	0.1	-0.4
Prospective memory result	0.4	0.5	1.3	0.2	0.6	-0.4	1.1	-0.6
Lung cancer (father)	0.4	0.5	1.8	-0.6	0.3	0.1	0.5	-1.3
Illnesses of mother	0.4	0.5	1.3	-0.6	0.7	-0.3	1.2	-0.4
Pulse wave Arterial Stiffness index	0.4	0.5	1.1	0.6	-0.6	-0.0	-0.8	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.3	0.5	1.1	-0.9	-0.5	0.5
Peak expiratory flow (PEF)	0.4	0.9	2.4	0.2	0.0	0.9	-1.6	1.0
Forced vital capacity (FVC), Best measure	0.4	1.6	4.3	-0.7	1.8	0.3	-2.1	-0.4
Emphysema/chronic bronchitis	0.4	0.5	0.9	0.0	1.0	0.9	-0.0	0.9
Pulse rate, automated reading	0.4	1.3	2.7	-0.6	-1.0	-1.6	0.3	-1.6
Diabetes diagnosed by doctor	0.4	0.7	1.7	-1.3	-0.8	-0.6	0.0	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.3	0.3	1.1	-0.4	0.2	-0.6
Medication for cholesterol	0.4	0.6	1.1	0.2	-0.8	1.0	1.0	0.2
Guilty feelings	0.4	0.6	1.2	0.9	-0.1	0.9	1.1	-0.1
Hearing aid user	0.4	0.5	0.9	-0.1	1.0	0.6	0.7	-0.8
Irritability	0.4	0.6	1.2	0.8	-0.3	1.1	1.0	0.4
Ever depressed for a whole week	0.4	0.5	1.2	0.3	1.1	0.8	0.5	-0.3
Alzheimer’s Disease (in mother)	0.3	0.4	1.5	0.4	-1.2	0.6	-0.0	-0.1
Age at First Birth	0.3	0.4	1.0	-0.8	0.3	-1.0	-0.4	0.3
HDL Cholesterol	0.3	0.6	0.9	-0.4	0.6	-0.9	-1.0	0.8
Schizophrenia (2014)	0.3	0.6	2.2	0.5	0.5	0.2	0.4	-1.5
Triglycerides	0.3	0.5	1.1	0.8	0.4	1.0	0.8	0.2
Heel T-Score	0.3	2.4	8.6	-1.4	0.8	-2.9	-0.5	0.7
Height	0.3	4.9	9.3	-2.1	-1.8	-1.1	-2.5	-3.0
Systolic Blood Pressure	0.3	1.6	2.5	1.3	-1.4	1.2	0.4	1.6
Relative age of first facial hair	0.3	0.7	1.6	-1.2	0.0	-0.7	-0.2	-1.3
Relative age voice broke	0.3	0.5	0.9	-1.0	-0.8	0.5	0.8	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.1	-0.3	1.0	-1.0	-0.5	0.7
Serious illness, injury or assault to yourself	0.3	0.3	0.9	0.4	-0.3	0.6	-0.3	0.9
Forced vital capacity (FVC)	0.3	1.2	3.7	-0.2	1.9	0.2	-1.3	-0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	0.9	0.0	0.4	1.0	0.0
Diabetes (self-reported)	0.3	0.4	0.8	-0.6	-0.9	-0.0	0.3	-0.9
Trunk fat-free mass	0.3	1.5	2.7	-1.2	-0.5	-1.1	-1.6	-1.3
Falls in the last year	0.3	0.4	1.5	-1.2	0.1	0.6	-0.2	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.0	-0.6	-0.7	-0.5	1.0	-0.2
Hair/balding pattern: Pattern 4	0.3	0.8	2.2	-0.3	1.5	0.9	-0.6	0.8
Blood clot in the leg (DVT)	0.3	0.4	1.0	-0.1	-0.8	-0.3	0.5	-1.0
Worry too long after embarrassment	0.3	0.5	1.2	-0.6	1.1	-0.1	-0.8	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.5	0.5	-0.6	-1.0	0.1
Suffer from ‘nerves’	0.3	0.5	1.0	1.0	1.0	0.7	-0.2	-0.2
Overall health rating	0.3	0.6	2.1	-0.3	-0.8	-0.4	-1.4	0.1
Family relationship satisfaction	0.3	0.4	1.0	0.6	-0.7	1.0	0.4	0.5
Leg pain on walking	0.3	0.3	1.3	0.0	1.1	-0.2	-0.6	-0.1
Knee pain experienced in last month	0.3	0.5	1.6	1.2	-0.5	0.2	0.7	0.2
Average weekly red wine intake	0.3	0.4	0.8	0.2	0.5	-0.9	-0.4	-0.9
Commuting to job workplace: Walk	0.3	0.4	0.8	0.4	-0.2	0.9	0.8	0.4
Medication: Gliclazide	0.3	0.3	0.9	-0.9	-0.0	0.6	-0.5	0.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.9	-0.3	-0.3	0.9	-0.7	0.1
Medication: Blood pressure	0.3	0.6	1.2	-0.2	-0.5	-0.9	-0.8	-1.1
Medication: Lisinopril	0.3	0.3	1.1	0.1	1.0	0.4	-0.0	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.0	-0.2	-0.7	-0.4	0.2	-1.0
Impedance of whole body	0.3	1.7	3.4	1.3	-0.5	1.8	1.3	1.2
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.0	-1.0	-1.0	-0.1	-0.7	0.2
Ulcerative Colitis (UC)	0.2	0.5	0.8	-0.9	0.7	0.5	0.4	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.9	-0.7	0.5	-0.2	-0.9	-0.9
Blood Red Count	0.2	2.3	7.0	-0.3	-1.3	0.7	-2.6	1.4
Blood White Count	0.2	1.6	6.4	-0.6	2.5	-0.3	-0.1	-1.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.9	-0.4	1.0	0.4	-0.1	0.0
Severe depression (siblings)	0.2	0.2	0.5	0.4	0.7	-0.3	0.3	-0.6
Impedance of leg (right)	0.2	0.9	1.5	0.7	-1.1	1.2	0.9	0.7
Leg fat-free mass (left)	0.2	1.0	2.8	-1.1	-0.2	-0.5	-1.7	-0.6
Leg predicted mass (left)	0.2	0.8	2.3	-1.1	-0.2	-0.4	-1.5	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.8	-0.7	0.9	-0.5	-0.4	0.3
Medication: Ramipril	0.2	0.2	0.9	0.3	-1.0	-0.2	0.0	-0.2
Worrier / anxious feelings	0.2	0.4	0.8	-0.5	0.9	0.8	-0.4	-0.6
Pulse rate	0.2	0.4	0.8	-0.3	-0.6	0.6	0.5	0.9
Medication: Lansoprazole	0.2	0.2	0.6	0.3	-0.8	-0.2	0.4	0.5
Impedance of arm (left)	0.2	0.8	1.8	0.9	-0.2	1.4	0.8	0.9
Trunk predicted mass	0.2	1.4	2.7	-1.2	-0.6	-1.0	-1.6	-1.3
Standing height	0.2	2.3	3.7	-1.7	-1.3	-0.3	-1.9	-1.8
Breastfed as a baby	0.2	0.3	1.2	-0.1	-0.2	-0.2	-0.2	-1.1
Arm fat-free mass (right)	0.2	0.8	1.8	-0.8	-0.2	-0.7	-1.3	-1.0
Age at first live birth	0.2	0.4	1.2	0.3	0.6	0.0	-1.1	0.5
Health satisfaction	0.2	0.3	0.8	0.2	0.4	0.9	-0.1	0.5
Qualifications: College or University degree	0.2	0.5	1.2	-0.2	1.1	0.9	-0.5	-0.0
Neck or shoulder pain in last month	0.2	0.3	1.1	1.1	0.5	-0.4	-0.2	-0.3
Medication: Blood pressure	0.2	0.3	0.8	0.9	0.6	0.3	0.5	0.1
Arm predicted mass (right)	0.2	0.9	2.4	-0.9	-0.1	-0.7	-1.6	-1.0
Comparative height size at age 10	0.2	1.4	3.5	-1.3	0.3	-0.8	-1.1	-1.9
Hypertension (Self-reported)	0.2	0.4	1.8	1.4	0.3	0.3	-0.3	-0.0
Illnesses of father: Heart disease	0.2	0.3	1.2	-0.4	0.5	-0.2	-1.1	-0.1
Whole body fat-free mass	0.2	1.1	2.6	-1.0	-0.4	-0.9	-1.6	-1.0
Medication: Aspirin	0.2	0.3	0.7	0.2	0.5	-0.8	0.2	-0.6
Smoking status: Current	0.2	0.4	1.2	0.1	-1.1	0.1	0.8	-0.0
Whole body water mass	0.2	1.2	2.3	-1.2	-0.3	-1.0	-1.5	-1.2
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	0.5	0.6	-0.2	0.2	-0.8
Medication: Atorvastatin	0.2	0.3	0.5	0.2	0.4	0.7	0.7	0.5
Basal metabolic rate	0.2	0.9	2.5	-0.9	-0.3	-0.7	-1.6	-0.7
Arm fat-free mass (left)	0.2	1.2	2.2	-1.2	-0.5	-1.0	-1.5	-0.9
Average weekly beer plus cider intake	0.2	0.3	1.2	-0.2	-0.4	-0.0	1.1	0.1
Cholesterol lowering medication	0.2	0.4	0.5	-0.7	-0.5	-0.7	-0.7	-0.2
Arm predicted mass (left)	0.2	1.0	2.0	-1.0	-0.7	-0.8	-1.4	-0.9
Crohns Disease (2017)	0.1	0.3	0.6	0.8	-0.5	0.1	0.6	-0.5
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	-0.1	0.3	0.5	0.4	-0.8
Blood Eosinophil Count	0.1	1.1	1.7	1.3	0.8	1.1	1.2	0.6
BMI	0.1	0.6	1.9	0.0	0.2	0.3	-0.9	1.4
Cardiovascular Disease	0.1	0.2	0.6	0.8	0.0	0.4	-0.0	0.3
Hair Pigment	0.1	4.1	10.3	1.4	0.3	2.7	3.2	1.1
Tanning	0.1	1.6	3.0	-1.4	-0.2	-1.1	-1.4	-1.7
Systolic blood pressure, automated reading	0.1	0.4	1.1	0.2	-1.0	-0.8	-0.4	-0.4
Trunk fat percentage	0.1	0.5	1.4	0.9	-0.1	0.3	-0.5	1.2
High blood pressure	0.1	0.3	1.0	1.0	0.1	-0.3	-0.4	-0.1
Body mass index (BMI)	0.1	0.3	0.7	0.3	0.0	-0.6	-0.8	0.8
Trunk fat mass	0.1	0.4	1.0	0.4	-0.0	-0.2	-1.0	0.8
Waist circumference	0.1	0.3	1.3	0.5	-1.1	-0.3	0.1	-0.3
Fluid intelligence score	0.1	0.1	0.2	0.4	0.5	0.1	-0.3	-0.4
Weight	0.1	0.6	2.5	-0.4	-0.4	-0.6	-1.6	0.0
Impedance of arm (right)	0.1	0.7	1.3	0.5	-0.8	1.1	0.5	1.0
Arm fat percentage (right)	0.1	0.5	1.6	0.4	-0.0	-0.4	-0.8	1.2
Hip circumference	0.1	0.3	0.5	0.7	0.4	0.6	0.3	0.4
Noisy workplace	0.1	0.1	0.4	0.6	0.2	0.3	-0.4	0.0
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.3	0.1	-0.5	-0.2	0.2
Arm fat mass (right)	0.1	0.5	1.4	0.2	-0.1	-0.7	-1.2	0.8
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	-0.5	-0.6	-0.2	-0.5	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	-0.5	0.4	0.1	0.0	-0.2
Body fat percentage	0.1	0.4	1.3	0.6	0.1	-0.1	-0.7	1.1
Leg fat percentage (right)	0.1	0.4	1.0	-0.0	0.0	-0.8	-0.7	1.0
Whole body fat mass	0.1	0.5	1.8	-0.0	-0.0	-0.6	-1.3	0.6
Leg fat mass (right)	0.1	0.5	1.2	-0.3	0.3	-0.7	-1.1	0.6
Leg fat-free mass (right)	0.1	0.7	2.2	-0.9	0.2	-0.3	-1.5	-0.5
Arm fat percentage (left)	0.1	0.5	1.6	0.6	0.4	-0.2	-0.6	1.2
Back pain experienced in last month	0.1	0.1	0.6	-0.3	0.1	-0.3	0.1	-0.7
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	-0.4	-0.5	0.2	0.1	0.4
Leg predicted mass (right)	0.1	0.6	2.0	-0.9	0.1	-0.2	-1.4	-0.5
Arm fat mass (left)	0.1	0.4	1.1	0.2	0.3	-0.7	-1.1	0.7
Leg fat percentage (left)	0.1	0.4	1.6	0.5	0.4	-0.3	-0.2	1.3
Risk taking	0.1	0.2	0.5	-0.6	-0.3	-0.7	0.1	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.1	-1.0	0.5	0.0	0.2	0.3
Leg fat mass (left)	0.1	0.4	0.8	-0.1	0.5	-0.5	-0.9	0.7
Medication: Aspirin	0.0	0.1	0.2	0.4	0.1	-0.3	0.0	-0.1

Hub : Genes

G3BP1

Models

Trait associations