Hub : Genes

GAB1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.041	0.026	0.00690	0.027	0.006	0.012	0.009	0.015	2.9e-04	0.05100	0.01300	0.025	0.00490
2	GTEx	Pancreas	0.175	0.065	0.00038	0.037	NA	0.042	NA	0.022	1.1e-02	NA	0.00740	NA	0.04100
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.064	0.035	0.00170	0.070	0.049	0.066	NA	0.070	7.9e-05	0.00087	0.00012	NA	0.00008

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.1	3.3	6.3	2.5	0.3	-1.9
Bipolar Disorder or Schizophrenia	0.8	1.9	4.2	2.0	0.0	-1.3
Depressed Affect (Nagel 2018)	2.1	4.5	6.2	2.5	1.7	-2.0
Depression (Nagel 2018)	0.6	0.9	1.9	0.7	1.4	-0.4
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.7	-0.9	-0.3	0.7
Neuroticism (Nagel 2018)	2.3	5.5	7.7	2.2	2.8	-2.0
Schizophrenia (2018)	0.1	0.2	0.4	0.6	-0.3	-0.1
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.1	-0.5	0.1
Worry (Nagel 2018)	2.9	6.2	7.1	2.3	2.7	-2.5
Alzheimer’s Disease (in mother)	0.1	0.2	0.2	0.5	0.3	-0.5
Alzheimer’s Disease (in father)	0.6	0.6	1.5	0.5	1.2	-0.3
Alzheimer’s Disease (including proxy)	0.2	0.4	1.1	-0.0	1.0	-0.0
Crohns Disease (2017)	0.1	0.3	0.6	0.2	-0.8	0.3
Irritable Bowel Disease (IBD)	0.2	0.4	0.9	0.1	-0.9	0.5
Ulcerative Colitis (UC)	0.3	0.5	1.5	-0.0	-1.2	0.2
Major Depression (MDD)	0.4	0.5	0.7	-0.6	-0.7	0.8
Reaction Time	0.2	0.4	1.0	0.5	1.0	-0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.2	-0.4	0.5	0.0
Breast Cancer	4.4	10.6	15.8	2.5	4.0	-3.1
Ovarian Cancer	0.2	0.3	0.6	0.5	0.3	-0.8
Prostate Cancer	0.9	1.2	1.9	1.1	0.8	-1.4
Age at First Birth	0.6	0.9	1.2	-1.1	-0.6	1.1
Bipolar Disorder (2011)	0.8	0.8	1.6	-0.1	-1.3	0.8
Body Mass Index (BMI) (2010)	1.0	1.4	2.0	-1.4	-0.5	1.4
Coronary Artery Disease (CAD)	2.0	2.4	3.3	-1.0	-1.7	1.8
Crohns Disease (2012)	1.1	1.8	3.2	-0.7	-1.8	1.3
Mean Putamen Volume	0.3	0.4	0.8	0.9	-0.0	-0.5
Fasting Glucose	0.7	0.8	0.9	1.0	1.0	-0.8
HbA1C	0.5	0.6	0.8	-0.5	-0.8	0.9
HDL Cholesterol	1.6	2.6	3.7	1.5	1.9	-1.4
LDL Cholesterol	0.1	0.2	0.5	-0.3	0.1	0.7
Lupus	0.9	1.3	3.4	0.4	1.8	-0.6
Neuroticism (2016)	0.7	1.0	1.2	1.1	0.9	-0.9
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.3	0.6	0.4
Rheumatoid Arthritis	0.0	0.1	0.2	0.4	0.1	-0.2
Schizophrenia (2014)	0.6	1.3	2.7	1.7	-0.0	-1.0
Triglycerides	0.3	0.4	1.0	-0.4	-0.3	1.0
Type 2 Diabetes (T2D) (2012)	3.2	3.7	5.8	-1.8	-1.4	2.4
Ulcerative Colitis	0.9	1.3	2.3	-0.7	-1.5	1.1
Blood Eosinophil Count	0.5	4.2	6.6	-1.9	-1.6	2.6
Blood Platelet Count	1.5	17.4	21.2	4.1	4.6	-3.7
Blood Red Count	0.5	4.7	10.0	1.9	0.8	-3.2
Blood White Count	1.6	12.1	17.9	4.2	2.6	-3.4
Heel T-Score	0.1	0.6	1.1	-1.0	0.8	-0.3
BMI	0.8	4.5	8.0	-2.3	-0.3	2.8
Height	2.8	54.1	60.5	7.5	6.8	-7.8
Waist Hip Ratio (WHR)	0.0	0.2	0.5	0.7	-0.2	-0.2
Systolic Blood Pressure	7.4	36.9	47.5	-6.6	-4.4	6.9
Smoking Status	1.2	2.9	3.9	1.7	2.0	-1.4
Allergy or Eczema	0.6	1.5	1.9	-1.1	-1.4	1.1
Cardiovascular Disease	6.0	19.9	27.7	-4.2	-3.8	5.3
Hypothyroidism (self reported)	0.1	0.2	0.7	-0.1	0.9	0.1
Respiratory disease	2.0	4.4	5.8	-2.2	-1.6	2.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.2	-0.4	-1.1	0.8
Lung FEV1/FVC ratio	1.0	5.3	6.2	1.9	2.5	-2.5
Lung FVC	0.3	1.3	2.0	0.7	1.4	-1.2
Neuroticism	3.0	7.3	8.2	2.9	2.6	-2.6
Chronotype (morning person)	0.6	1.3	3.4	0.3	1.8	-0.7
Hair Pigment	0.0	1.1	1.7	-0.8	-0.9	1.3
Tanning	0.0	0.2	0.5	-0.7	0.2	0.2
Hand grip strength (left)	1.2	3.1	3.9	1.4	2.0	-1.8
Number of treatments/medications taken	2.6	4.6	5.5	-2.1	-2.0	2.4
Average weekly spirits intake	0.4	0.5	1.3	-0.3	1.2	0.2
Sensitivity / hurt feelings	0.4	0.7	2.0	-0.0	1.4	0.4
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.6	1.3	0.5	-0.8
Hearing difficulty/problems: Yes	0.5	0.7	1.3	-0.7	-1.1	0.7
Relative age of first facial hair	0.1	0.2	0.4	0.7	-0.3	-0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.3	-0.2	-0.6	0.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.8	0.9	0.2	-0.5
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	0.3	0.5	-0.5
Systolic blood pressure, automated reading	3.1	9.0	12.9	-3.6	-1.6	3.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.4	0.6	-0.3
Angina	0.9	1.2	3.3	-0.5	-1.8	0.3
Medication for hormone replacement therapy	0.4	0.5	1.3	0.4	1.1	-0.2
Vitamin and mineral supplements	3.5	4.7	8.6	-1.6	-2.9	1.7
Supplements: Zinc	0.9	1.0	1.3	0.8	1.2	-0.9
Medication: Co-codamol	0.9	1.0	1.1	1.1	0.9	-1.0
Medication: Metformin	0.5	0.6	1.7	0.1	-1.3	0.4
Diabetes (father)	0.8	0.9	1.3	-1.1	-0.5	1.2
Diabetes (mother)	0.4	0.5	1.2	0.5	-1.1	-0.3
Severe depression (siblings)	0.9	1.0	1.8	1.3	0.7	-0.8
Pack years adult smoking proportion	0.9	1.4	2.0	-1.3	-0.7	1.4
Impedance of leg (right)	1.2	5.8	10.0	2.7	0.5	-3.2
Leg fat-free mass (left)	0.2	1.2	3.1	0.6	1.8	-0.2
Trunk fat percentage	0.3	1.2	2.9	0.6	1.7	-0.7
Hand grip strength (right)	0.7	1.8	2.1	1.2	1.4	-1.4
Townsend deprivation index at recruitment	0.4	0.6	0.8	-0.8	0.7	0.9
Current tobacco smoking	0.0	0.1	0.2	0.0	0.5	-0.0
Average weekly fortified wine intake	0.7	0.8	1.2	0.9	0.7	-1.1
Maternal smoking around birth	4.8	6.9	8.4	2.9	2.4	-2.5
Fed-up feelings	0.6	1.1	2.2	0.9	1.5	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.4	-0.2	0.6	0.5
Relative age voice broke	0.4	0.6	1.1	1.1	-0.4	-0.7
Taking other prescription medications	1.8	2.8	4.2	-1.9	-0.9	2.1
Age when periods started (menarche)	0.2	0.5	0.8	0.7	0.3	-0.9
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.6	0.8	1.2	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.8	-0.5	0.9	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.6	0.0	0.6
Qualifications: CSEs or equivalent	0.7	0.9	1.9	-0.9	-0.1	1.4
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.5	0.1	0.4
High blood pressure	5.7	15.8	21.3	-3.9	-3.3	4.6
Hayfever, allergic rhinitis or eczema	0.6	1.3	1.8	-1.3	-0.7	1.3
Multivitamins +/- minerals	5.1	6.4	13.1	1.6	3.6	-1.9
Stomach or abdominal pain in last month	0.0	0.0	0.1	-0.0	0.3	-0.0
Supplements: Glucosamine	0.9	1.2	2.1	0.7	1.5	-0.9
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	1.8	-1.3	-0.7	1.2
Medication: Atenolol	3.1	3.9	6.3	-1.6	-2.5	1.6
Medication: Levothyroxine sodium	0.2	0.4	0.7	-0.5	0.9	0.4
Sitting height	1.7	12.0	12.3	3.5	3.4	-3.5
Chronic bronchitis/emphysema (father)	1.5	1.7	3.6	-0.9	-1.9	1.0
High blood pressure (mother)	1.9	2.7	3.1	-1.5	-1.7	1.8
Body mass index (BMI)	0.7	2.8	4.9	-1.9	-0.2	2.2
Impedance of leg (left)	1.3	6.4	11.1	2.8	0.7	-3.3
Leg predicted mass (left)	0.2	1.2	3.2	0.7	1.8	-0.2
Trunk fat mass	0.4	1.5	3.4	0.8	1.9	-0.7
Waist circumference	0.1	0.3	0.7	-0.3	0.3	0.8
Number of incorrect matches in round	0.9	1.5	2.1	1.4	0.6	-1.4
Past tobacco smoking	1.5	2.8	4.4	-1.5	-2.1	1.3
Alcohol usually taken with meals	0.8	1.4	2.1	-1.2	-0.7	1.5
Nervous feelings	1.6	2.9	3.6	1.9	1.3	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.5	0.7	0.5	-0.1
Hearing difficulty/problems with background noise	0.1	0.1	0.4	-0.2	-0.6	-0.1
Hair/balding pattern: Pattern 2	0.8	1.0	1.6	-0.9	1.2	0.9
Had menopause	0.0	0.1	0.1	-0.2	-0.3	-0.2
Had other major operations	0.4	0.5	0.9	0.6	1.0	-0.4
Forced vital capacity (FVC)	1.5	5.8	6.7	2.1	2.6	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	0.9	0.8	0.8	-0.9
Ever unenthusiastic/disinterested for a whole week	3.0	3.7	4.0	-2.0	-1.8	2.0
Qualifications: None of the above	1.8	3.8	5.3	1.7	1.8	-2.3
Financial difficulties in last 2 years	2.5	3.4	6.0	1.6	2.5	-1.3
Mouth/teeth dental problems	2.9	4.4	8.9	-1.6	-3.0	1.4
Heart attack	0.4	0.5	1.1	-1.1	-0.1	0.7
Allergy	2.4	5.5	7.6	2.8	1.1	-2.8
Pain all over the body in last month	1.2	1.3	2.2	-1.1	-0.5	1.5
Diabetes (self-reported)	0.4	0.6	1.4	0.5	-1.2	-0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.4	-0.4	0.2
Medication: Ramipril	1.0	1.2	1.5	-1.1	-1.0	1.2
Medication: Simvastatin	1.7	2.5	3.9	-1.2	-2.0	1.4
Fluid intelligence score	0.2	0.3	0.5	-0.7	-0.7	0.3
Illnesses of siblings	1.3	1.8	4.4	0.6	2.1	-0.9
Neuroticism score	2.2	4.5	5.7	2.4	2.0	-1.9
Weight	0.2	1.2	3.2	0.5	1.8	-0.2
Impedance of arm (right)	1.5	7.2	8.2	2.4	2.8	-2.9
Arm fat percentage (right)	0.3	1.1	1.4	-1.0	0.9	1.2
Trunk fat-free mass	0.2	1.0	1.8	0.8	1.4	-0.6
Hip circumference	0.1	0.3	0.8	0.0	0.9	0.3
Time employed in main current job	0.1	0.2	0.2	0.5	0.2	-0.4
Alcohol intake versus 10 years previously	0.1	0.2	0.4	0.2	-0.6	-0.3
Father’s age at death	0.5	0.7	0.9	0.8	0.7	-1.0
Worrier / anxious feelings	0.8	1.5	2.0	1.1	1.4	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.0	-0.1	0.5
Falls in the last year	0.0	0.1	0.1	0.3	-0.3	-0.2
Hair/balding pattern: Pattern 3	2.7	4.0	4.8	1.7	2.1	-2.2
Number of live births	0.9	1.3	3.5	0.3	1.9	-0.5
Forced expiratory volume in 1-second (FEV1)	1.9	6.4	7.7	2.0	2.8	-2.7
Pulse rate	1.4	2.3	3.0	-1.6	-1.1	1.7
Happiness	3.1	3.7	5.4	2.3	0.6	-2.3
Noisy workplace	0.1	0.2	0.3	-0.4	-0.5	-0.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.9	-0.9	0.0	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	0.2	0.0	-0.5
Mouth/teeth dental problems: Dentures	1.5	2.5	2.9	1.7	1.4	-1.7
Asthma	1.0	1.9	2.4	-1.3	-1.3	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.0	1.0	-0.4	-0.8
Medication: Cholesterol lowering	3.0	4.7	5.2	-2.2	-2.0	2.3
Depression (self-reported)	0.7	0.8	1.5	1.2	0.7	-0.6
Medication: Lansoprazole	0.8	0.9	1.4	-1.1	-0.2	1.2
Prospective memory result	0.9	1.0	1.3	1.1	0.8	-1.2
Lung cancer (father)	0.7	0.8	1.8	-0.3	-1.3	0.7
Illnesses of mother	0.4	0.5	0.7	0.8	-0.2	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.6	8.2	2.5	2.3	-2.9
Pulse wave Arterial Stiffness index	0.4	0.4	0.7	0.9	0.1	-0.7
Impedance of arm (left)	1.6	7.5	8.5	2.5	2.8	-2.9
Arm fat mass (right)	0.2	1.0	1.3	-0.8	1.2	1.0
Trunk predicted mass	0.2	1.0	2.0	0.9	1.4	-0.6
Standing height	2.4	24.3	25.5	5.0	4.7	-5.0
Length of working week for main job	1.1	1.3	2.1	-0.9	1.4	0.9
Exposure to tobacco smoke at home	0.0	0.0	0.1	-0.1	-0.2	0.3
Breastfed as a baby	0.1	0.2	0.3	-0.5	0.2	0.5
Tense / ‘highly strung’	2.4	3.9	4.1	1.9	2.0	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.4	0.4	-0.2
Hair/balding pattern: Pattern 4	0.4	0.9	2.4	0.4	-1.6	-0.4
Birth weight of first child	0.3	0.5	1.1	-0.3	-1.1	0.4
Peak expiratory flow (PEF)	1.2	2.8	5.5	1.1	2.3	-1.3
Pulse wave reflection index	1.2	1.5	2.6	1.6	0.2	-1.4
Ever highly irritable/argumentative for 2 days	1.9	2.2	2.9	1.6	1.1	-1.7
Loud music exposure frequency	1.8	2.0	3.2	-1.8	0.4	1.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.6	1.3	0.0	-0.8
Mouth/teeth dental problems: Bleeding gums	3.3	4.2	8.8	1.3	3.0	-1.5
Blood clot in the leg (DVT)	0.5	0.7	1.2	-1.1	-0.5	0.8
Medication: Paracetamol	0.6	1.0	1.8	-1.3	0.2	1.0
Headache pain in last month	0.6	1.0	1.4	-1.0	-1.2	0.8
Medication for cholesterol, blood pressure or diabetes	4.6	7.6	10.1	3.0	1.9	-3.2
Glaucoma (self-reported)	0.3	0.3	0.5	0.7	-0.2	-0.6
Gout (self-reported)	1.4	1.9	2.7	-1.5	-0.9	1.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.6	0.1	1.3	-0.2
Medication: Amlodipine	0.9	1.3	1.6	-1.1	-1.0	1.3
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.0	-1.1	-1.4	0.9
Birth weight	1.0	2.2	3.2	1.5	1.0	-1.8
Chronic bronchitis/emphysema (mother)	0.6	0.8	1.7	-0.6	1.3	0.5
High blood pressure (siblings)	3.1	4.5	5.1	-1.9	-2.2	2.3
Forced vital capacity (FVC), Best measure	1.7	6.2	7.0	2.3	2.5	-2.6
Body fat percentage	0.1	0.5	1.5	0.1	1.2	0.0
Leg fat percentage (right)	0.1	0.4	0.7	-0.6	-0.2	0.9
Arm fat-free mass (right)	0.1	0.5	0.7	0.8	0.7	-0.6
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.7	0.2	0.8
Comparative body size at age 10	0.2	0.4	1.1	0.4	1.0	0.2
Number of full brothers	0.7	0.9	2.2	-0.6	-1.5	0.5
Worry too long after embarrassment	0.2	0.3	0.6	0.5	0.8	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.6	-1.6	0.0	1.2
Wheeze or whistling in the chest in last year	2.5	4.5	6.9	-2.4	-1.0	2.6
Number of children fathered	0.4	0.5	0.9	0.9	0.3	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	0.2	-0.2	-0.0
Age at first live birth	1.1	1.9	2.2	-1.5	-1.2	1.4
Pulse wave peak to peak time	0.1	0.1	0.2	-0.4	0.3	0.2
Health satisfaction	0.3	0.3	0.4	-0.7	0.5	0.6
Shortness of breath walking on level ground	0.3	0.4	0.8	-0.5	0.3	0.9
Qualifications: College or University degree	0.0	0.0	0.1	0.3	0.1	-0.1
Eye problems/disorders: None of the above	0.4	0.5	1.2	0.3	-1.1	-0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	0.7	-0.1	-0.5
Emphysema/chronic bronchitis	0.9	1.0	1.8	-1.1	-0.4	1.3
Medication for pain relief, constipation, heartburn	0.7	1.1	1.8	1.4	0.3	-1.2
Neck or shoulder pain in last month	1.1	1.5	2.5	-1.0	1.6	1.0
Medication: Blood pressure	6.4	11.3	14.3	-3.8	-2.3	3.8
Angina (self-reported)	1.1	1.4	3.6	-0.6	-1.9	0.5
Migraine (self-reported)	0.1	0.1	0.2	0.4	0.4	-0.3
Medication: Ibuprofen	0.3	0.4	0.6	0.8	0.2	-0.7
Medication: Allopurinol	1.7	2.3	3.4	-1.9	-0.5	1.8
Medication: Omeprazole	0.5	0.6	1.6	-0.3	1.3	0.2
Medication: Seretide 50 evohaler	0.0	0.1	0.1	0.2	0.1	0.3
Mean time to correctly identify matches	0.1	0.1	0.2	0.5	0.2	-0.4
Heart disease (mother)	1.0	1.2	1.8	-1.3	-0.2	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.9	0.0	1.0	0.0
Whole body fat mass	0.1	0.4	1.2	0.1	1.1	0.1
Leg fat mass (right)	0.1	0.3	0.5	-0.4	0.5	0.7
Arm predicted mass (right)	0.1	0.4	0.6	0.8	0.7	-0.5
Pulse rate, automated reading	2.0	6.5	10.1	-2.9	-1.0	3.2
Alcohol intake frequency.	0.0	0.0	0.1	0.3	-0.1	-0.1
Comparative height size at age 10	1.7	9.4	11.6	3.2	2.4	-3.4
Number of full sisters	1.7	2.1	3.3	-1.8	0.3	1.7
Suffer from ‘nerves’	1.4	2.2	2.8	1.2	1.7	-1.5
Overall health rating	0.4	0.8	1.3	-1.0	-0.3	1.1
Chest pain or discomfort	2.7	4.0	5.8	-2.4	-0.7	2.4
Had major operations	0.3	0.4	1.0	0.3	-1.0	0.0
Age at last live birth	0.5	0.7	1.0	-1.0	-0.1	1.0
Family relationship satisfaction	0.7	0.8	2.2	0.4	-1.5	-0.4
Leg pain on walking	2.3	2.9	4.2	-1.7	2.0	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	-0.1	-0.8	0.1
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.3	-0.0	-0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.4	-0.3	-0.4
Medication: Aspirin	2.0	2.6	4.2	-1.4	-2.0	1.3
Supplements: Vitamin C	0.4	0.5	0.9	0.5	1.0	-0.5
Knee pain experienced in last month	0.5	0.8	1.2	-1.1	0.5	1.0
Hypertension (Self-reported)	7.1	19.8	25.7	-4.4	-3.8	5.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	3.8	-1.6	-1.1	2.0
Illnesses of father: Heart disease	0.2	0.2	0.3	0.4	0.6	-0.4
Illnesses of siblings: Diabetes	0.9	1.1	2.0	1.2	-0.2	-1.4
Smoking status: Previous	2.6	3.9	4.3	2.1	1.9	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	4.4	1.9	2.1	-1.5
Whole body fat-free mass	0.2	1.1	2.4	0.8	1.5	-0.4
Leg fat-free mass (right)	0.2	1.2	3.0	0.7	1.7	-0.3
Arm fat percentage (left)	0.2	1.0	1.3	-0.9	0.8	1.2
Average weekly red wine intake	6.8	10.0	12.3	-3.0	-3.0	3.5
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.8	-0.9	-0.2	0.7
Mood swings	1.4	2.5	4.5	2.1	1.0	-1.4
Loneliness, isolation	1.0	1.3	1.9	1.1	1.4	-0.9
Long-standing illness, disability or infirmity	5.2	8.0	8.1	-2.8	-2.8	2.8
Ever had bowel cancer screening	0.2	0.2	0.5	-0.7	0.3	0.1
Diabetes diagnosed by doctor	0.2	0.3	0.7	0.3	-0.9	0.1
Ever had stillbirth, spontaneous miscarriage or termination	5.4	5.8	10.2	2.2	3.2	-1.6
Friendships satisfaction	0.4	0.5	1.5	-0.0	-1.2	-0.3
Qualifications: nursing, teaching	0.5	0.8	1.3	-0.8	-0.7	1.1
Commuting to job workplace: Walk	0.3	0.3	0.4	0.7	-0.6	-0.5
Eye problems/disorders: Cataract	0.1	0.2	0.4	-0.6	0.2	0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.2	-0.0	-0.1	1.1
Medication for cholesterol	0.4	0.6	1.1	0.3	0.8	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	0.8	-0.9	0.5	0.9
Back pain experienced in last month	0.4	0.5	1.1	-0.6	1.0	0.4
Mineral and other dietary supplements	2.6	3.4	6.9	-1.2	-2.6	1.4
Breast cancer (self-reported)	0.6	0.8	1.1	-0.8	-0.7	1.1
Asthma (self-reported)	1.0	2.0	2.5	-1.4	-1.2	1.6
Osteoporosis (self-reported)	0.6	0.8	1.2	1.1	0.5	-1.0
Osteoarthritis (self-reported)	0.6	0.8	1.2	-1.0	0.3	1.1
Medication: Aspirin	1.9	2.5	4.9	-1.1	-2.2	1.1
Medication: Gliclazide	0.1	0.1	0.3	-0.2	-0.5	0.3
Illnesses of father: None of the above (group 1)	0.6	0.7	1.1	0.7	1.1	-0.7
Smoking status: Current	0.1	0.1	0.3	-0.2	0.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.1	0.5	0.3	-1.1
Whole body water mass	0.2	1.0	2.3	0.8	1.5	-0.5
Leg predicted mass (right)	0.2	1.2	3.1	0.7	1.8	-0.3
Arm fat mass (left)	0.2	0.8	1.0	-0.7	1.0	0.9
Number of self-reported non-cancer illnesses	6.1	10.5	13.1	-3.3	-2.7	3.6
Average weekly champagne plus white wine intake	3.6	4.9	5.8	2.4	1.9	-2.3
Miserableness	1.4	2.3	3.8	1.9	1.3	-1.3
Guilty feelings	1.9	2.9	4.8	1.7	2.2	-1.1
Wears glasses or contact lenses	0.9	1.0	2.2	-0.9	-1.5	0.2
Ever taken oral contraceptive pill	2.1	2.4	5.4	1.0	2.3	-0.8
Hearing aid user	1.4	1.5	3.1	-0.7	-1.8	1.0
Mother’s age at death	2.0	2.5	3.0	1.2	1.7	-1.7
Financial situation satisfaction	0.4	0.5	0.9	0.6	0.2	-1.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.3	0.2	1.2	-0.3
Commuting to job workplace: Public transport	0.3	0.4	0.7	0.8	-0.5	-0.4
Eye problems/disorders: Glaucoma	0.4	0.5	0.8	0.9	0.3	-0.8
Medication: Blood pressure	2.6	4.9	7.3	-2.0	-1.9	2.7
Pain type(s) experienced in last month: Hip pain	1.4	1.7	2.1	-1.2	1.4	1.3
Supplements: Fish oil (including cod liver oil)	1.1	1.4	3.1	0.5	1.8	-0.8
High cholesterol (Self-reported)	2.5	4.4	5.2	-2.0	-2.0	2.3
Medication: Bendroflumethiazide	3.2	4.8	6.7	-2.3	-1.5	2.6
Medication: Paracetamol	0.9	1.3	2.3	-1.5	-0.3	1.3
Medication: Lisinopril	5.4	7.0	10.4	-2.0	-3.2	2.5
Medication: Atorvastatin	3.1	3.8	4.9	-1.9	-1.7	2.2
Illnesses of father: High blood pressure	0.8	1.0	1.3	-0.9	-1.1	0.9
Alcohol drinker status: Never	0.0	0.0	0.1	0.3	0.1	-0.2
Ever smoked	2.6	4.5	8.1	1.7	2.8	-1.5
Basal metabolic rate	0.2	1.2	2.9	0.8	1.7	-0.4
Leg fat percentage (left)	0.1	0.3	0.5	-0.5	0.1	0.7
Arm fat-free mass (left)	0.1	0.4	0.5	0.7	0.7	-0.5
Number of operations (self-reported)	0.3	0.5	1.3	-0.2	1.1	0.4
Average weekly beer plus cider intake	1.5	2.1	3.1	1.4	1.2	-1.8
Irritability	1.4	2.4	2.7	1.6	1.5	-1.4
Risk taking	0.3	0.4	0.5	0.7	0.6	-0.7
Ever had prostate specific antigen (PSA) test	1.0	1.1	1.4	-1.0	1.0	1.2
Fractured/broken bones in last 5 years	0.1	0.2	0.3	0.6	0.4	-0.2
Age started oral contraceptive pill	1.2	1.5	2.8	1.2	0.4	-1.7
Diastolic blood pressure, automated reading	3.1	9.6	13.6	-3.7	-1.2	3.7
Ever depressed for a whole week	0.6	0.8	1.1	-0.7	-1.1	0.9
Unable to work because of sickness or disability	0.8	1.0	1.6	-0.8	-0.8	1.3
Commuting to job workplace: Cycle	0.6	0.7	1.3	-0.8	-0.2	1.1
Myopia	2.1	3.0	5.0	-1.6	-2.2	1.2
Vascular/heart problems diagnosed by doctor	6.8	18.6	24.1	4.3	3.7	-4.9
Cholesterol lowering medication	0.3	0.5	1.0	-0.2	-1.0	0.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.3	-0.3	1.5	0.2
Pain experienced in last month	1.3	2.1	2.5	1.4	-1.6	-1.4
Supplements: Calcium	1.6	1.7	3.3	1.1	1.8	-0.9
Basal cell carcinoma (self-reported)	1.5	1.8	4.4	0.7	2.1	-0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.9	-1.0	-0.2	0.7
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.3	-1.1	-0.7	0.9
Heart disease (siblings)	0.9	1.1	3.3	-0.2	-1.8	0.3
Alcohol drinker status: Previous	1.1	1.2	2.6	0.7	1.6	-0.7
Pack years of smoking	0.8	1.1	1.4	-1.2	-0.9	1.1
Impedance of whole body	2.0	10.2	15.0	3.3	2.1	-3.9
Leg fat mass (left)	0.1	0.3	0.6	-0.3	0.7	0.5
Arm predicted mass (left)	0.2	0.8	1.0	0.9	1.0	-0.8