TWAS hub - GABRP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Colon Adenocarcinoma	0.089	0.040	1.1e-03	0.007	0.033	0.005	NA	0.011	0.120	5.3e-03	1.6e-01	NA	7.6e-02
2	TCGA	Glioblastoma Multiforme	0.152	0.072	5.6e-03	0.043	0.094	0.097	NA	0.133	0.019	8.7e-04	7.4e-04	NA	7.7e-05
3	TCGA	Thyroid Carcinoma	0.135	0.056	4.1e-05	-0.002	0.046	0.041	NA	0.012	0.510	2.5e-05	7.2e-05	NA	2.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Pain experienced in last month	8.3	13.8	26.9	5.2	-0.4	-3.8
Medication: Co-codamol	7.2	8.3	14.9	-2.3	-2.2	3.9
Headache pain in last month	6.0	10.3	16.6	-3.8	-0.1	4.1
Neck or shoulder pain in last month	6.0	8.6	13.2	-3.5	-0.1	3.6
Back pain experienced in last month	5.4	7.8	11.4	-3.3	1.0	3.4
Medication: Gliclazide	5.4	6.1	13.3	-3.7	-1.0	2.0
Exposure to tobacco smoke outside home	4.7	6.3	9.9	-1.9	-3.1	2.4
Ever taken oral contraceptive pill	3.7	4.1	5.8	-2.4	0.9	2.4
Hearing aid user	3.6	4.1	6.2	-2.5	-2.1	1.3
Average weekly fortified wine intake	3.5	4.1	6.0	-2.2	-2.4	1.2
Number of children fathered	3.1	3.5	5.8	-2.0	-1.0	2.4
Chest pain or discomfort	3.1	4.5	7.4	-2.7	-0.8	2.3
Had major operations	3.1	3.7	5.7	-2.4	-0.4	2.3
Number of operations (self-reported)	3.1	4.6	6.8	-2.6	1.6	2.1
Supplements: Calcium	2.9	3.2	4.7	-2.2	1.2	1.9
Medication: Lisinopril	2.8	3.6	5.6	-2.3	-0.3	2.4
Medication: Metformin	2.6	3.6	4.8	-2.2	-1.4	2.1
Qualifications: CSEs or equivalent	2.6	3.5	6.2	-1.9	2.5	-0.9
Chronic bronchitis/emphysema (father)	2.6	3.1	5.2	-2.3	-1.7	1.1
Serious illness, injury or assault to yourself	2.4	2.9	6.9	-2.6	-0.4	1.3
Number of full brothers	2.4	3.1	4.5	1.1	2.1	-1.9
Medication: Blood pressure	2.3	4.1	6.6	-2.6	-0.4	2.4
Pain type(s) experienced in last month: Hip pain	2.3	2.9	4.3	-2.1	-0.5	2.0
Age at First Birth	2.2	3.1	5.4	2.3	-1.8	-0.8
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	4.8	-1.5	-0.8	2.2
Allergy	2.0	4.5	5.2	2.3	2.2	-1.9
Pain all over the body in last month	2.0	2.1	5.2	-2.3	-0.9	0.6
Arm fat percentage (right)	2.0	8.0	13.1	-3.6	3.0	1.3
Number of live births	2.0	2.9	5.1	-2.3	1.8	0.3
Worry too long after embarrassment	2.0	3.3	5.2	2.3	-1.4	-1.7
Diabetes (father)	1.9	2.3	4.8	1.3	0.7	-2.2
Fractured/broken bones in last 5 years	1.9	2.4	5.1	-2.3	0.0	1.5
Vitamin and mineral supplements	1.8	2.5	7.2	-0.4	-2.7	0.3
Supplements: Zinc	1.8	2.0	3.0	-1.5	-0.8	1.7
Arm fat mass (right)	1.8	7.3	13.6	-3.7	2.6	1.2
Exposure to tobacco smoke at home	1.8	2.0	5.2	-2.3	-0.9	0.3
Tense / ‘highly strung’	1.8	2.9	6.5	2.5	-1.4	-0.4
Medication for cholesterol, blood pressure or diabetes	1.8	2.9	4.4	2.0	-0.6	-2.1
Comparative body size at age 10	1.8	5.1	12.1	-3.5	-0.4	1.7
Supplements: Vitamin C	1.8	2.1	4.1	-1.5	-0.4	2.0
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	2.6	-1.6	-1.5	1.3
Taking other prescription medications	1.7	2.6	4.6	-2.1	-0.3	1.8
Falls in the last year	1.7	2.3	5.8	-2.4	-0.4	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	6.2	-2.5	0.2	0.7
Medication: Ibuprofen	1.7	2.0	5.1	-2.3	-0.0	1.0
Leg fat mass (right)	1.7	6.6	14.1	-3.8	1.5	1.9
Commuting to job workplace: Public transport	1.7	2.1	5.1	-0.0	-2.3	-1.0
Financial difficulties in last 2 years	1.6	2.2	5.6	-2.4	0.7	0.7
Father’s age at death	1.6	2.1	2.4	1.3	1.5	-1.5
Asthma	1.6	3.1	5.0	-2.2	-1.5	1.5
Arm fat percentage (left)	1.6	6.3	11.0	-3.3	2.6	1.0
Arm fat mass (left)	1.6	6.6	12.7	-3.6	2.5	0.9
Age started oral contraceptive pill	1.6	2.0	4.2	1.0	-2.0	0.9
Smoking Status	1.5	3.7	7.0	-2.7	1.7	-1.0
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	2.4	-1.3	-0.9	1.5
Medication: Atenolol	1.5	1.9	4.4	-0.8	2.1	0.8
Birth weight	1.5	3.3	7.8	-2.8	-0.6	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	2.6	-1.0	-1.6	1.4
Number of self-reported non-cancer illnesses	1.5	2.5	5.1	-2.3	-0.3	1.5
Leg fat mass (left)	1.5	5.8	13.0	-3.6	1.4	1.6
Mean Putamen Volume	1.4	1.6	4.1	0.4	2.0	-0.7
Trunk fat percentage	1.4	5.6	8.5	-2.9	2.6	1.1
Trunk fat mass	1.4	6.0	11.4	-3.4	2.3	1.2
Body fat percentage	1.4	5.6	10.1	-3.2	2.1	1.5
Age at first live birth	1.4	2.5	3.9	2.0	-1.8	-0.7
Illnesses of siblings: Diabetes	1.4	1.8	3.1	1.4	-0.4	-1.8
Asthma (self-reported)	1.4	2.8	4.3	-2.1	-1.5	1.3
Coronary Artery Disease (CAD)	1.3	1.6	2.6	-1.6	-0.2	1.4
Type 2 Diabetes (T2D) (2018)	1.3	2.4	6.3	-2.5	-0.1	1.0
Ever had hysterectomy (womb removed)	1.3	1.5	4.4	-0.3	2.1	-0.1
Medication: Simvastatin	1.3	1.9	4.5	0.7	2.1	-0.9
Hair/balding pattern: Pattern 3	1.3	1.9	4.6	2.1	-0.1	-1.0
Whole body fat mass	1.3	5.5	10.4	-3.2	2.2	1.1
Mineral and other dietary supplements	1.3	1.7	3.0	-0.7	-1.7	1.3
Leg fat percentage (left)	1.3	4.5	9.8	-3.1	0.7	1.8
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.3	-0.5	1.8	0.9
Ever depressed for a whole week	1.3	1.6	2.6	-1.6	0.6	1.3
Myopia	1.3	1.9	4.0	0.8	-1.1	-2.0
BMI	1.2	7.0	13.5	-3.7	2.7	-0.1
Angina	1.2	1.6	2.9	-1.7	0.7	1.2
Body mass index (BMI)	1.2	5.0	10.8	-3.3	1.9	0.7
Waist circumference	1.2	4.6	10.1	-3.2	1.5	1.1
Past tobacco smoking	1.2	2.2	3.9	1.4	-2.0	0.9
Diabetes (self-reported)	1.2	1.8	2.4	-1.5	-0.9	1.6
Mouth/teeth dental problems: Dentures	1.2	2.0	5.4	-2.3	-0.4	0.8
Leg fat percentage (right)	1.2	4.4	8.9	-3.0	0.8	1.9
Qualifications: College or University degree	1.2	3.9	8.2	1.8	-2.9	-0.6
Schizophrenia (2014)	1.1	2.5	5.7	-2.4	-1.1	0.7
Respiratory disease	1.1	2.5	3.5	-1.9	-1.5	1.4
Townsend deprivation index at recruitment	1.1	1.5	3.2	-1.8	-0.4	1.1
Multivitamins +/- minerals	1.1	1.4	1.9	1.3	1.4	-0.8
Leg predicted mass (left)	1.1	5.8	9.9	-3.1	2.7	0.2
Had other major operations	1.1	1.3	3.0	-1.7	-0.3	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.5	1.9	-0.6	-0.2
Medication for pain relief, constipation, heartburn	1.1	1.8	3.0	1.7	-1.1	-1.1
Angina (self-reported)	1.1	1.4	2.4	-1.6	0.9	1.0
Fasting Glucose	1.0	1.2	2.9	-0.7	1.7	-0.4
HDL Cholesterol	1.0	1.6	4.8	2.2	0.4	-0.1
Lupus	1.0	1.5	2.6	-1.6	-1.4	-0.5
Rheumatoid Arthritis	1.0	1.4	3.7	0.0	1.9	0.7
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.7	1.6	0.1	-0.9
Relative age of first facial hair	1.0	2.0	4.0	-0.4	-2.0	1.4
Impedance of leg (right)	1.0	4.7	8.5	2.3	-2.9	0.5
Leg fat-free mass (left)	1.0	5.5	9.6	-3.1	2.6	0.2
Hand grip strength (right)	1.0	2.8	4.3	2.1	-0.5	-2.0
Impedance of leg (left)	1.0	5.0	11.0	2.0	-3.3	0.4
Weight	1.0	5.0	11.8	-3.4	1.6	0.9
Medication: Cholesterol lowering	1.0	1.6	4.3	-0.6	2.1	-0.1
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	5.0	0.8	-0.3	-2.2
Wheeze or whistling in the chest in last year	1.0	1.8	4.5	-2.1	-0.0	1.0
Emphysema/chronic bronchitis	1.0	1.1	1.3	-1.1	-1.1	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	2.8	0.8	1.7	-0.3
Overall health rating	1.0	2.2	4.7	-1.2	0.6	2.2
Smoking status: Previous	1.0	1.5	3.8	-0.8	1.9	-0.4
Leg fat-free mass (right)	1.0	5.3	9.7	-3.1	2.5	-0.0
Long-standing illness, disability or infirmity	1.0	1.6	2.2	-1.2	-1.0	1.5
Leg predicted mass (right)	1.0	5.5	10.0	-3.2	2.5	0.1
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.7	1.9	-0.0	-1.6
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.4	-1.1	-0.1	1.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.3	-0.8	0.1	1.5
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.2	-1.0	-1.1	0.8
Stomach or abdominal pain in last month	0.9	1.1	1.5	-1.0	0.9	1.2
Medication: Levothyroxine sodium	0.9	1.6	1.8	1.2	-1.3	-1.3
Number of incorrect matches in round	0.9	1.5	3.3	-1.1	-0.2	1.8
Hip circumference	0.9	3.9	8.9	-3.0	1.6	0.5
Time employed in main current job	0.9	1.0	2.4	1.5	0.8	0.3
Breastfed as a baby	0.9	1.2	3.5	1.9	-0.2	0.2
Birth weight of first child	0.9	1.6	4.0	-2.0	-0.4	0.9
Heart disease (mother)	0.9	1.1	2.8	0.6	0.4	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.2	-1.0	1.5	0.2
Medication: Aspirin	0.9	1.1	1.9	-1.4	1.1	0.3
Illnesses of father: None of the above (group 1)	0.9	1.1	3.1	0.1	1.8	0.5
Financial situation satisfaction	0.9	1.1	1.9	-1.2	-1.4	0.3
Supplements: Fish oil (including cod liver oil)	0.9	1.2	1.6	0.6	1.3	-1.2
Ever smoked	0.9	1.7	4.2	-2.0	0.9	0.1
Prostate Cancer	0.8	1.1	2.1	-1.0	0.3	1.5
Neuroticism (2016)	0.8	1.1	1.5	1.1	0.8	-1.2
Primary Biliary Cirrhosis	0.8	1.2	2.7	1.6	0.9	-0.0
Number of treatments/medications taken	0.8	1.5	2.5	-1.3	0.4	1.6
Pack years adult smoking proportion	0.8	1.3	2.5	-0.9	1.6	0.7
Medication: Ramipril	0.8	1.0	2.0	-1.4	-0.2	1.0
Worrier / anxious feelings	0.8	1.4	4.0	2.0	0.2	-0.5
Shortness of breath walking on level ground	0.8	0.9	2.0	0.0	0.8	-1.4
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.5	-0.6	-1.6	0.1
Migraine (self-reported)	0.8	0.9	1.7	-0.2	1.3	-1.0
Qualifications: nursing, teaching	0.8	1.2	3.2	-0.3	-1.8	0.6
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	1.9	1.3	-0.4	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	2.9	-1.4	-1.7	0.7
Wears glasses or contact lenses	0.8	1.0	1.6	1.0	0.6	-1.3
Medication: Atorvastatin	0.8	1.0	1.6	-1.1	-1.3	0.6
LDL Cholesterol	0.7	1.1	1.8	0.8	-0.9	-1.4
Hearing difficulty/problems: Yes	0.7	1.0	1.2	-1.0	1.1	0.9
Systolic blood pressure, automated reading	0.7	1.9	5.2	0.6	-2.3	0.3
Diabetes (mother)	0.7	0.9	1.1	-0.9	-1.1	0.8
Current tobacco smoking	0.7	1.2	3.4	-1.8	0.1	-0.3
Age when periods started (menarche)	0.7	1.7	3.9	2.0	-0.2	-1.1
Hayfever, allergic rhinitis or eczema	0.7	1.6	2.9	-0.8	-1.1	1.7
Mouth/teeth dental problems	0.7	1.1	3.2	1.8	-0.4	0.1
Heart attack	0.7	0.9	2.3	-0.3	1.5	0.6
Lung cancer (father)	0.7	0.8	1.3	-1.1	-0.0	1.1
Length of working week for main job	0.7	0.7	1.9	-1.4	0.5	0.1
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.4	-1.2	-0.4	1.1
Eye problems/disorders: None of the above	0.7	0.8	1.1	1.0	0.9	-0.6
Medication: Seretide 50 evohaler	0.7	0.9	2.3	0.6	-0.2	-1.5
Number of full sisters	0.7	0.8	2.1	-1.4	0.6	-0.2
Age at last live birth	0.7	1.1	1.9	1.4	-1.1	-0.1
Knee pain experienced in last month	0.7	1.1	2.4	-1.5	-0.0	1.0
Ever had bowel cancer screening	0.7	0.8	1.3	-0.8	-1.1	0.7
Basal metabolic rate	0.7	3.8	9.1	-3.0	1.5	0.3
Unable to work because of sickness or disability	0.7	1.0	2.8	-1.7	0.2	0.2
Commuting to job workplace: Cycle	0.7	0.8	1.3	0.7	-0.7	-1.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.6	-0.2	1.6	0.3
Intelligence (Savage-Jansen 2018)	0.6	1.9	4.1	2.0	-0.2	-1.3
Body Mass Index (BMI) (2010)	0.6	0.8	2.2	-0.3	1.5	0.2
HbA1C	0.6	0.7	0.8	0.9	0.9	0.6
Hypothyroidism (self reported)	0.6	1.5	2.7	-0.0	-1.3	-1.7
Lung FEV1/FVC ratio	0.6	3.3	4.3	-1.4	-1.9	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.2	-1.0	-1.1	0.3
Alcohol usually taken with meals	0.6	0.9	1.8	0.7	-1.4	0.6
Hair/balding pattern: Pattern 4	0.6	1.5	3.9	-0.3	0.7	2.0
Loud music exposure frequency	0.6	0.6	0.9	-0.8	0.5	-0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.0	-0.9	0.7	-1.0
Glaucoma (self-reported)	0.6	0.7	1.9	-1.4	-0.3	0.4
Gout (self-reported)	0.6	0.8	2.1	-0.5	-1.5	-0.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.2	-0.0	1.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.3	0.1	-1.2	1.5
Average weekly red wine intake	0.6	0.9	2.3	0.7	-1.5	0.1
Diabetes diagnosed by doctor	0.6	0.9	1.1	-1.0	-0.8	1.0
Osteoarthritis (self-reported)	0.6	0.8	1.3	0.9	-0.5	1.1
Whole body water mass	0.6	3.2	7.7	-2.8	1.3	0.1
Guilty feelings	0.6	0.9	2.1	-0.0	-0.8	1.4
Medication: Paracetamol	0.6	1.0	1.9	-1.4	0.3	1.0
Arm fat-free mass (left)	0.6	3.0	8.5	-2.9	0.5	0.5
Pack years of smoking	0.6	0.9	1.8	-0.5	1.4	0.7
Arm predicted mass (left)	0.6	2.9	7.9	-2.8	0.7	0.5
Schizophrenia vs Biploar Disorder	0.5	0.7	1.3	0.3	1.1	0.8
Worry (Nagel 2018)	0.5	1.1	2.8	1.7	0.4	-0.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	-0.0	1.0	-0.9
Systolic Blood Pressure	0.5	2.5	4.5	1.7	-2.1	-0.2
High blood pressure (mother)	0.5	0.6	1.3	0.3	1.2	-0.7
Hearing difficulty/problems with background noise	0.5	0.7	1.1	0.4	-1.0	1.0
Had menopause	0.5	0.6	1.8	1.4	0.0	-0.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.8	-1.3	-0.1	0.3
Neuroticism score	0.5	1.0	2.9	1.7	-0.3	-0.2
Pulse rate	0.5	0.8	1.8	-0.7	-1.3	-0.6
Medication: Paracetamol	0.5	0.9	1.6	-1.3	0.4	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.3	-0.8	1.1	-0.3
Medication: Omeprazole	0.5	0.6	1.3	-0.1	-1.1	0.8
Leg pain on walking	0.5	0.6	1.3	-0.7	-0.2	1.1
Whole body fat-free mass	0.5	3.1	7.4	-2.7	1.3	0.2
Smoking status: Current	0.5	0.9	2.2	-1.5	0.1	-0.6
Irritability	0.5	0.9	1.4	-1.0	0.1	1.2
Risk taking	0.5	0.8	1.3	-1.2	-0.5	0.8
Basal cell carcinoma (self-reported)	0.5	0.6	1.6	-0.5	-1.3	0.3
Heart disease (siblings)	0.5	0.6	0.9	-0.4	-0.9	0.9
Depression (Nagel 2018)	0.4	0.7	1.9	0.1	0.2	-1.4
Ulcerative Colitis	0.4	0.6	1.4	1.2	0.5	-0.1
Hand grip strength (left)	0.4	1.0	1.8	1.1	0.1	-1.3
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.2	-1.1	-0.4	-0.4
Severe depression (siblings)	0.4	0.5	0.9	-0.4	1.0	-0.6
Forced vital capacity (FVC)	0.4	1.4	1.9	-1.4	-1.1	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.2	0.1	-1.5	-0.7
Fluid intelligence score	0.4	0.9	1.1	1.0	1.1	-0.8
Alcohol intake versus 10 years previously	0.4	0.6	1.1	0.8	0.3	-1.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	1.6	-1.3	-1.3	0.9
Happiness	0.4	0.5	1.3	-1.2	-0.4	0.1
Noisy workplace	0.4	0.5	0.9	1.0	-0.1	-0.8
Depression (self-reported)	0.4	0.5	0.9	0.0	-1.0	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	2.2	-1.0	-1.5	0.5
Peak expiratory flow (PEF)	0.4	0.9	1.6	-1.3	-0.7	0.7
Arm fat-free mass (right)	0.4	2.0	6.0	-2.4	0.3	0.2
Medication: Allopurinol	0.4	0.5	1.0	-1.0	0.3	0.6
Arm predicted mass (right)	0.4	2.1	6.2	-2.5	0.1	0.1
Comparative height size at age 10	0.4	2.2	5.0	-2.2	-0.1	1.3
Hypertension (Self-reported)	0.4	1.0	1.7	-1.0	-0.5	1.3
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.7	-0.8	0.7	0.2
Cholesterol lowering medication	0.4	0.6	1.2	0.8	0.1	-1.1
Impedance of whole body	0.4	2.0	4.3	2.1	-1.2	0.1
Bipolar Disorder (2018)	0.3	0.4	1.0	0.3	-0.5	-1.0
Irritable Bowel Disease (IBD)	0.3	0.8	2.2	1.5	-0.3	0.1
Breast Cancer	0.3	0.7	1.6	1.3	-0.6	-0.3
Bipolar Disorder (2011)	0.3	0.3	0.7	-0.0	-0.8	-0.4
Crohns Disease (2012)	0.3	0.5	0.8	0.6	-0.5	0.9
Triglycerides	0.3	0.4	0.6	0.4	0.7	-0.8
Allergy or Eczema	0.3	0.8	1.7	-0.5	0.7	1.3
Neuroticism	0.3	0.7	2.0	1.4	-0.0	-0.5
Maternal smoking around birth	0.3	0.4	1.0	-0.3	0.5	-1.0
Fed-up feelings	0.3	0.6	1.0	1.0	0.9	-0.2
Sitting height	0.3	1.8	2.5	-1.5	-1.6	0.9
Nervous feelings	0.3	0.5	1.2	1.1	0.4	-0.2
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	-0.1	-0.4	-1.1
Trunk fat-free mass	0.3	1.8	5.2	-2.3	0.5	0.0
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	1.1	-0.6	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.6	0.8	-0.0	-0.6
Illnesses of mother	0.3	0.4	0.8	-0.1	-0.9	-0.6
Trunk predicted mass	0.3	1.9	5.4	-2.3	0.5	0.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.0	-1.0	-0.4	0.2
Blood clot in the leg (DVT)	0.3	0.3	0.5	-0.7	0.6	-0.5
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.6	-0.6	0.8	0.2
Forced vital capacity (FVC), Best measure	0.3	1.0	2.0	-1.4	-0.8	0.5
Health satisfaction	0.3	0.3	0.5	0.7	0.6	-0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.8	0.6	-0.3	0.9
Medication: Aspirin	0.3	0.4	1.1	-1.1	0.2	0.4
Illnesses of father: Heart disease	0.3	0.4	0.7	-0.5	-0.8	0.4
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	0.4	0.3	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.5	-0.3	0.7
Friendships satisfaction	0.3	0.4	0.5	-0.6	-0.7	0.7
Commuting to job workplace: Walk	0.3	0.3	0.7	0.3	0.3	-0.8
Mother’s age at death	0.3	0.4	0.8	-0.9	-0.3	0.4
Eye problems/disorders: Glaucoma	0.3	0.4	0.9	-0.4	-1.0	0.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.5	0.9	0.1	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	-0.1	-1.0	0.4
Bipolar Disorder or Schizophrenia	0.2	0.4	0.4	-0.6	-0.5	-0.7
Depressed Affect (Nagel 2018)	0.2	0.4	1.1	0.3	1.1	-0.0
Neuroticism (Nagel 2018)	0.2	0.5	0.8	0.9	0.6	-0.4
Schizophrenia (2018)	0.2	0.5	1.2	-1.1	-0.5	-0.0
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.6	-0.3	0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.4	-0.3	0.6	-0.6
Crohns Disease (2017)	0.2	0.4	1.0	1.0	-0.5	-0.1
Ulcerative Colitis (UC)	0.2	0.5	1.1	1.1	-0.3	0.4
Major Depression (MDD)	0.2	0.3	0.4	-0.5	0.4	0.6
Reaction Time	0.2	0.3	0.7	-0.4	0.2	0.8
Waist Hip Ratio (WHR)	0.2	0.8	1.0	-1.0	-1.0	0.6
Relative age voice broke	0.2	0.3	0.6	0.8	0.4	-0.4
High blood pressure	0.2	0.6	0.8	-0.6	-0.8	0.9
Supplements: Glucosamine	0.2	0.2	0.4	-0.3	0.6	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.5	0.2	-0.7	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	-0.8	-0.6	0.1
Prospective memory result	0.2	0.3	0.9	-0.0	0.2	-0.9
Impedance of arm (left)	0.2	1.0	2.9	1.7	0.1	-0.1
Pulse wave reflection index	0.2	0.3	0.5	0.5	-0.2	0.7
Medication: Amlodipine	0.2	0.3	0.5	0.6	-0.7	0.2
Mean time to correctly identify matches	0.2	0.4	0.7	-0.0	0.7	0.9
Pulse rate, automated reading	0.2	0.7	1.3	0.1	-0.8	-1.1
Alcohol intake frequency.	0.2	0.5	0.9	0.9	-0.0	-0.9
Mood swings	0.2	0.4	0.7	-0.0	0.8	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.5	0.6	-0.0
Breast cancer (self-reported)	0.2	0.2	0.4	-0.4	0.4	-0.6
Osteoporosis (self-reported)	0.2	0.3	0.5	-0.7	0.4	0.4
Average weekly beer plus cider intake	0.2	0.3	0.7	-0.3	0.8	0.3
Diastolic blood pressure, automated reading	0.2	0.6	1.1	-1.1	-0.7	0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	-0.4	0.3	-0.6
Alcohol drinker status: Previous	0.2	0.2	0.4	0.6	-0.2	0.5
Ovarian Cancer	0.1	0.2	0.4	-0.1	0.3	0.6
Blood Platelet Count	0.1	0.8	1.8	-1.4	-0.2	-0.7
Blood Red Count	0.1	0.7	1.1	1.1	0.0	-1.0
Heel T-Score	0.1	1.0	2.9	-0.1	-1.7	-0.4
Cardiovascular Disease	0.1	0.2	0.4	-0.6	0.2	-0.5
Tanning	0.1	1.0	1.3	-0.7	1.0	-1.1
Average weekly spirits intake	0.1	0.1	0.2	0.2	0.3	-0.4
Sensitivity / hurt feelings	0.1	0.2	0.5	0.4	-0.7	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	0.1	-0.8	-0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	-0.6	0.2	-0.2
Qualifications: None of the above	0.1	0.3	0.8	-0.9	0.2	-0.2
Impedance of arm (right)	0.1	0.7	1.2	1.1	0.8	0.4
Medication: Lansoprazole	0.1	0.1	0.1	-0.4	0.0	-0.2
Pulse wave Arterial Stiffness index	0.1	0.2	0.2	0.5	-0.2	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.5	0.3	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	0.1	0.2	0.5
High blood pressure (siblings)	0.1	0.1	0.3	-0.3	0.5	0.3
Pulse wave peak to peak time	0.1	0.1	0.2	-0.3	0.4	0.2
Suffer from ‘nerves’	0.1	0.2	0.5	0.7	0.4	0.2
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.1	-0.4	0.1
Miserableness	0.1	0.2	0.5	-0.1	-0.1	0.7
Medication: Blood pressure	0.1	0.2	0.6	0.8	-0.3	-0.0
Illnesses of father: High blood pressure	0.1	0.2	0.4	0.2	-0.7	0.1
Blood Eosinophil Count	0.0	0.2	0.5	-0.7	0.2	-0.0
Blood White Count	0.0	0.3	1.0	-1.0	0.2	-0.1
Height	0.0	0.4	1.2	0.2	1.1	-0.3
Lung FVC	0.0	0.1	0.3	-0.0	0.0	-0.6
Chronotype (morning person)	0.0	0.1	0.2	-0.0	0.4	-0.4
Hair Pigment	0.0	0.9	1.3	-1.1	-0.8	1.0
Medication for hormone replacement therapy	0.0	0.1	0.2	0.1	0.4	-0.0
Illnesses of siblings	0.0	0.0	0.1	-0.1	-0.1	0.3
Standing height	0.0	0.2	0.5	-0.7	-0.4	0.2
Family relationship satisfaction	0.0	0.1	0.1	0.3	0.2	0.2
Loneliness, isolation	0.0	0.0	0.0	-0.1	0.0	0.2
Medication for cholesterol	0.0	0.1	0.1	-0.4	0.0	0.3
Average weekly champagne plus white wine intake	0.0	0.1	0.2	-0.0	0.0	0.4
High cholesterol (Self-reported)	0.0	0.1	0.1	-0.3	-0.0	-0.3
Medication: Bendroflumethiazide	0.0	0.0	0.1	-0.3	-0.0	-0.2
Alcohol drinker status: Never	0.0	0.0	0.0	0.1	-0.1	0.1

Hub : Genes

GABRP

Models

Trait associations