Hub : Genes

GALNT2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1090 0.0390 2.2e-03 0.027 0.028 0.060 0.044 0.063 2.9e-04 2.3e-04 8.2e-08 4.6e-06 3.5e-08
2 GTEx Brain Cerebellum 0.4170 0.1040 8.5e-04 0.084 NA 0.009 NA 0.027 1.8e-03 NA 1.7e-01 NA 5.6e-02
3 GTEx Esophagus Mucosa 0.2730 0.0590 8.2e-06 0.239 NA 0.196 NA 0.228 4.7e-16 NA 3.9e-13 NA 2.6e-15
4 METSIM Adipose 0.0978 0.0314 1.4e-04 0.063 0.036 0.044 0.050 0.059 9.4e-10 3.4e-06 3.0e-07 5.8e-08 3.5e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.7 1.1 2.3 -1.5 -0.7 -1.2 0.4
Bipolar Disorder or Schizophrenia 0.7 1.7 3.1 0.1 1.6 -1.2 1.8
Depressed Affect (Nagel 2018) 2.2 4.6 10.2 -0.6 3.2 -0.8 -2.7
Depression (Nagel 2018) 3.8 5.6 16.1 -0.3 4.0 -2.5 0.2
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.6 -0.1 -0.5 -1.3 -0.2
Neuroticism (Nagel 2018) 1.9 4.5 15.4 -0.4 3.9 -1.4 -0.7
Schizophrenia (2018) 1.6 3.3 7.1 1.4 2.7 -0.6 2.0
Schizophrenia vs Biploar Disorder 3.3 4.3 8.8 2.8 3.0 1.0 0.0
Worry (Nagel 2018) 2.0 4.2 11.9 0.4 3.5 -1.0 1.9
Alzheimer’s Disease (in mother) 0.6 0.7 1.8 0.8 0.1 0.6 1.4
Alzheimer’s Disease (in father) 0.4 0.5 0.9 -0.9 -1.0 -0.2 -0.1
Alzheimer’s Disease (including proxy) 0.2 0.2 0.8 0.1 -0.0 0.4 0.9
Crohns Disease (2017) 1.7 3.7 13.9 -0.7 -3.7 0.5 0.6
Irritable Bowel Disease (IBD) 1.5 3.5 13.5 0.0 -3.7 0.5 0.7
Ulcerative Colitis (UC) 0.6 1.1 3.3 0.9 -1.8 0.6 0.4
Major Depression (MDD) 0.9 1.1 1.4 -0.9 1.2 -0.9 -1.1
Reaction Time 0.5 0.9 2.8 -0.6 0.2 -1.7 0.7
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.4 -0.6 -0.7 0.0 0.0
Breast Cancer 0.3 0.6 1.9 0.4 -0.1 0.6 -1.4
Ovarian Cancer 0.3 0.3 0.7 -0.5 -0.3 -0.9 0.5
Prostate Cancer 0.3 0.4 0.9 1.0 0.2 0.5 -0.7
Age at First Birth 0.6 0.9 2.7 -0.3 1.6 0.6 0.6
Bipolar Disorder (2011) 1.4 1.4 5.3 0.0 -0.5 0.1 2.3
Body Mass Index (BMI) (2010) 0.8 1.1 3.9 2.0 -0.3 0.6 -0.4
Coronary Artery Disease (CAD) 1.6 1.9 3.8 -0.1 -1.8 0.7 -2.0
Crohns Disease (2012) 1.4 2.2 5.2 -0.4 -2.3 -0.3 1.9
Mean Putamen Volume 1.9 2.1 8.1 0.4 0.4 0.1 2.9
Fasting Glucose 1.2 1.4 3.4 1.9 0.4 1.3 -0.5
HbA1C 1.3 1.4 3.3 1.5 -0.0 -0.6 1.8
HDL Cholesterol 14.7 24.5 87.6 1.4 -2.1 -2.0 9.4
LDL Cholesterol 0.5 0.8 2.5 0.1 -1.6 -0.7 -0.5
Lupus 0.1 0.2 0.4 -0.5 0.6 -0.5 -0.0
Neuroticism (2016) 2.4 3.5 6.5 1.2 2.2 1.1 -2.5
Primary Biliary Cirrhosis 2.0 2.8 5.7 2.4 1.1 -2.0 0.7
Rheumatoid Arthritis 0.2 0.3 0.7 0.3 0.6 -0.8 0.3
Schizophrenia (2014) 1.3 2.8 7.5 0.5 2.7 -1.0 1.6
Triglycerides 10.3 16.9 55.8 -1.0 2.8 1.7 -7.5
Type 2 Diabetes (T2D) (2012) 0.4 0.5 0.8 0.9 -0.9 0.1 -0.6
Ulcerative Colitis 0.4 0.6 1.0 1.0 -0.9 0.5 0.6
Blood Eosinophil Count 0.5 3.7 12.1 0.5 -3.5 -0.8 1.3
Blood Platelet Count 4.4 50.9 171.6 0.2 -4.8 -2.9 13.1
Blood Red Count 0.6 5.5 15.4 -2.6 0.2 0.3 -3.9
Blood White Count 0.6 4.1 8.4 -0.8 2.9 1.6 -2.2
Heel T-Score 0.2 1.5 3.4 -1.2 0.4 -1.0 1.8
BMI 1.5 8.9 28.7 -1.9 1.8 0.3 -5.4
Height 0.4 7.6 24.5 -2.1 -0.1 1.2 5.0
Waist Hip Ratio (WHR) 0.5 2.4 6.9 0.1 -1.7 -2.6 0.3
Systolic Blood Pressure 0.4 1.9 4.1 0.0 -1.8 -0.4 2.0
Smoking Status 1.6 3.9 14.4 -0.4 -0.6 -3.8 -0.7
Allergy or Eczema 0.0 0.0 0.1 -0.3 0.0 -0.0 -0.2
Cardiovascular Disease 0.2 0.8 3.0 -0.1 0.3 0.5 -1.7
Hypothyroidism (self reported) 0.6 1.4 2.2 -1.0 -1.5 1.1 -1.1
Respiratory disease 0.2 0.4 1.0 -1.0 -0.5 0.2 -0.5
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.3 0.4 -0.5 0.2 -1.1
Lung FEV1/FVC ratio 0.1 0.7 1.7 0.4 0.7 -1.3 -0.6
Lung FVC 0.3 1.3 2.6 -1.1 0.5 -1.2 1.6
Neuroticism 2.6 6.2 18.7 1.0 4.3 -1.3 -1.8
Chronotype (morning person) 0.2 0.4 0.5 0.7 -0.7 0.1 -0.7
Hair Pigment 0.0 0.7 2.5 -1.6 0.1 0.3 -0.1
Tanning 0.1 1.3 2.0 1.3 -0.3 -1.4 -1.3
Hand grip strength (left) 0.2 0.5 1.6 -1.2 0.1 -0.2 0.7
Number of treatments/medications taken 0.8 1.5 4.6 -0.5 1.0 0.5 -2.1
Average weekly spirits intake 1.0 1.2 1.8 -1.0 -1.4 -1.3 -0.6
Sensitivity / hurt feelings 1.7 2.8 8.8 0.3 3.0 -0.6 -1.4
Frequency of depressed mood in last 2 weeks 3.8 5.3 14.1 -0.2 3.8 -2.5 -1.1
Hearing difficulty/problems: Yes 1.1 1.7 2.9 -1.2 1.7 -1.0 -1.2
Relative age of first facial hair 1.3 2.6 7.4 0.7 -0.0 2.7 -1.6
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 3.3 -1.8 1.6 0.4 -0.6
Ever used hormone-replacement therapy (HRT) 1.3 1.7 2.8 1.3 0.9 -1.7 -1.2
Ever had hysterectomy (womb removed) 0.4 0.4 0.5 0.7 0.5 -0.7 -0.7
Systolic blood pressure, automated reading 1.0 3.0 6.1 -2.4 -2.5 0.4 -0.2
Eye problems/disorders: Diabetes related eye disease 3.0 3.3 10.4 -0.0 -0.3 1.6 -3.2
Angina 0.9 1.2 1.8 -0.2 1.1 1.3 -1.4
Medication for hormone replacement therapy 0.4 0.5 0.6 0.6 -0.7 -0.8 -0.7
Vitamin and mineral supplements 1.0 1.3 4.3 -0.3 -2.1 0.3 -0.9
Supplements: Zinc 1.0 1.1 3.3 1.0 -0.0 -0.3 1.8
Medication: Co-codamol 1.3 1.5 3.0 -0.6 1.7 -0.2 -1.6
Medication: Metformin 0.3 0.4 0.7 0.5 0.8 0.2 -0.8
Diabetes (father) 1.1 1.3 3.9 0.3 -2.0 -0.8 0.8
Diabetes (mother) 0.2 0.3 1.0 -1.0 0.2 0.1 0.1
Severe depression (siblings) 1.7 1.9 3.6 -1.9 0.4 -0.4 -1.9
Pack years adult smoking proportion 1.3 1.9 4.7 -1.1 0.6 1.2 -2.2
Impedance of leg (right) 0.8 3.8 11.9 0.4 -1.7 3.5 0.6
Leg fat-free mass (left) 0.3 1.5 2.9 -1.7 1.0 -1.5 -0.3
Trunk fat percentage 2.3 9.2 22.7 -1.9 0.7 3.2 -4.8
Hand grip strength (right) 0.4 1.1 1.9 -1.4 1.4 0.7 -0.1
Townsend deprivation index at recruitment 3.0 4.2 8.5 2.0 1.6 -1.2 -2.9
Current tobacco smoking 1.3 2.1 4.0 -1.0 -1.8 -2.0 -0.4
Average weekly fortified wine intake 0.4 0.4 0.8 -0.7 0.5 -0.3 0.9
Maternal smoking around birth 0.6 0.8 2.8 0.1 -0.5 -1.7 0.4
Fed-up feelings 3.4 6.1 12.6 -0.1 3.5 -1.1 -3.2
Frequency of unenthusiasm / disinterest in last 2 weeks 3.8 5.1 10.6 0.0 3.1 -3.2 -0.5
Relative age voice broke 0.4 0.6 2.1 -0.3 -0.1 0.6 -1.4
Taking other prescription medications 0.7 1.1 2.3 -1.2 -0.0 0.7 -1.5
Age when periods started (menarche) 1.0 2.3 6.9 -0.4 1.4 2.6 -0.3
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 1.9 1.0 1.3 0.5 -1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.3 0.2 1.1 0.6 0.6
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 1.6 -1.0 0.2 -1.2 -1.1
Qualifications: CSEs or equivalent 2.7 3.6 9.1 -1.4 1.0 1.5 -3.0
Serious illness, injury or assault to yourself 2.4 3.0 10.5 0.2 1.1 -0.4 -3.2
High blood pressure 0.2 0.5 0.9 -0.7 -0.8 0.9 0.1
Hayfever, allergic rhinitis or eczema 0.0 0.0 0.1 -0.1 -0.2 -0.0 0.3
Multivitamins +/- minerals 0.3 0.3 0.7 -0.2 0.8 -0.4 0.7
Stomach or abdominal pain in last month 1.6 2.0 2.6 -1.0 -1.6 -1.3 1.6
Supplements: Glucosamine 0.5 0.6 1.8 1.4 0.5 0.4 -0.5
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 3.4 -0.2 0.2 1.2 -1.8
Medication: Atenolol 2.2 2.8 5.6 1.6 2.4 0.6 -1.6
Medication: Levothyroxine sodium 0.3 0.5 1.8 -0.3 -0.2 0.1 -1.4
Sitting height 0.5 3.4 10.1 -0.9 -1.5 0.5 3.2
Chronic bronchitis/emphysema (father) 0.8 0.9 1.1 1.1 -0.8 1.0 -0.9
High blood pressure (mother) 0.7 1.1 1.7 -0.9 -1.1 -0.7 1.3
Body mass index (BMI) 1.4 6.0 20.2 -1.7 0.8 0.4 -4.5
Impedance of leg (left) 0.8 4.0 12.3 0.4 -1.9 3.5 0.3
Leg predicted mass (left) 0.3 1.5 3.0 -1.7 0.9 -1.5 -0.4
Trunk fat mass 1.4 6.2 14.4 -2.3 0.8 2.1 -3.8
Waist circumference 1.0 3.5 12.0 -1.5 -0.0 -0.0 -3.5
Number of incorrect matches in round 0.7 1.2 2.3 -1.1 1.1 -0.3 1.5
Past tobacco smoking 1.0 1.8 6.7 -0.3 -0.8 2.6 0.1
Alcohol usually taken with meals 0.9 1.4 3.7 1.9 -0.3 1.1 0.8
Nervous feelings 1.5 2.8 9.1 1.1 3.0 -0.5 0.8
Frequency of tenseness / restlessness in last 2 weeks 3.0 4.7 11.7 -0.6 3.4 -2.6 -0.3
Hearing difficulty/problems with background noise 1.2 1.9 5.0 -2.2 0.9 -0.4 -1.2
Hair/balding pattern: Pattern 2 0.5 0.7 2.2 -1.5 -0.8 -0.0 0.1
Had menopause 0.4 0.5 1.3 1.1 0.3 0.5 -0.6
Had other major operations 0.3 0.3 0.8 0.9 0.5 -0.1 -0.5
Forced vital capacity (FVC) 0.2 0.7 2.0 -1.4 -0.2 0.1 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 1.9 -0.8 1.4 1.2 0.3
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 2.7 0.6 1.6 -1.6 -1.1
Qualifications: None of the above 0.7 1.6 3.7 0.6 1.9 1.5 -0.4
Financial difficulties in last 2 years 3.1 4.1 6.7 -0.2 2.6 -2.5 -2.0
Mouth/teeth dental problems 1.8 2.8 7.2 -2.7 -1.9 0.4 -0.2
Heart attack 1.2 1.6 5.2 0.3 1.0 0.2 -2.3
Allergy 0.2 0.4 1.3 -0.4 0.1 -0.1 1.2
Pain all over the body in last month 0.8 0.8 2.0 1.4 0.7 -0.4 -0.7
Diabetes (self-reported) 0.2 0.4 0.6 0.8 -0.7 -0.0 -0.7
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.9 -0.2 -0.1 -1.0 0.4
Medication: Ramipril 0.5 0.7 0.9 0.9 -0.8 -0.7 -0.9
Medication: Simvastatin 0.4 0.6 1.3 -0.9 0.1 -1.1 -0.6
Fluid intelligence score 0.0 0.1 0.2 0.0 0.3 -0.0 0.5
Illnesses of siblings 1.1 1.5 4.8 -0.9 -0.0 -0.7 2.2
Neuroticism score 3.5 7.4 22.8 0.7 4.8 -1.6 -2.0
Weight 0.6 2.9 6.2 -2.2 0.2 0.4 -2.5
Impedance of arm (right) 0.3 1.6 6.1 0.2 -0.2 2.5 0.3
Arm fat percentage (right) 1.9 7.3 22.4 -1.5 1.2 1.7 -4.7
Trunk fat-free mass 0.3 1.8 3.0 -1.7 0.1 -1.5 1.3
Hip circumference 1.0 4.5 12.3 -1.4 -0.1 1.9 -3.5
Time employed in main current job 0.2 0.2 0.5 -0.0 0.2 0.7 0.5
Alcohol intake versus 10 years previously 0.3 0.5 0.6 0.7 0.7 0.6 0.8
Father’s age at death 0.5 0.7 1.4 -0.9 -1.2 0.1 0.6
Worrier / anxious feelings 2.2 4.1 16.0 0.7 4.0 -0.2 0.3
Frequency of tiredness / lethargy in last 2 weeks 2.8 4.5 12.5 -1.1 3.5 -1.4 -1.5
Falls in the last year 0.4 0.6 1.6 0.3 1.3 -0.8 -0.3
Hair/balding pattern: Pattern 3 2.4 3.5 8.1 2.9 -1.8 -1.1 1.3
Number of live births 0.1 0.1 0.3 0.3 0.6 -0.1 -0.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.6 -1.3 -0.1 -0.2 0.4
Pulse rate 0.6 1.0 2.5 -0.4 -1.1 -0.4 -1.6
Happiness 0.4 0.5 1.1 0.7 0.5 -1.1 -0.2
Noisy workplace 0.4 0.5 1.7 -0.4 -1.3 -0.0 0.1
Qualifications: A levels/AS levels or equivalent 1.2 2.7 6.8 0.3 0.2 -2.6 2.0
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.9 2.5 1.5 1.3 -1.6 -1.0
Mouth/teeth dental problems: Dentures 1.5 2.5 8.0 2.8 -1.3 0.4 0.5
Asthma 0.1 0.1 0.2 -0.5 -0.4 0.4 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.6 -1.6 0.7 0.3 -0.6
Medication: Cholesterol lowering 0.3 0.4 0.9 -0.2 1.0 -0.3 -0.9
Depression (self-reported) 0.6 0.7 2.6 -0.3 1.6 0.3 -0.0
Medication: Lansoprazole 0.8 1.0 1.8 -0.7 0.5 1.1 -1.4
Prospective memory result 2.1 2.6 6.2 1.6 2.5 0.1 -1.2
Lung cancer (father) 0.9 1.0 2.2 0.9 1.5 1.0 -0.0
Illnesses of mother 0.8 1.0 2.3 1.5 1.0 -0.8 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 2.1 -1.4 0.2 0.2 0.3
Pulse wave Arterial Stiffness index 1.5 1.8 2.8 -1.6 -1.7 -0.5 1.2
Impedance of arm (left) 0.6 2.9 11.1 -0.0 -0.6 3.3 -0.0
Arm fat mass (right) 1.5 6.0 17.9 -1.7 1.0 1.4 -4.2
Trunk predicted mass 0.3 1.6 2.7 -1.6 0.2 -1.4 1.3
Standing height 0.4 4.4 13.8 -1.6 -1.0 0.7 3.7
Length of working week for main job 0.7 0.8 1.5 -0.4 -0.7 -1.0 1.2
Exposure to tobacco smoke at home 1.6 1.8 4.8 0.6 1.3 -2.2 0.7
Breastfed as a baby 0.4 0.5 0.9 0.6 -0.4 -0.9 0.6
Tense / ‘highly strung’ 2.1 3.5 8.4 2.0 2.9 -1.2 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.7 9.4 0.3 2.2 -3.1 0.6
Hair/balding pattern: Pattern 4 0.2 0.4 0.6 -0.8 0.3 0.7 -0.6
Birth weight of first child 1.0 1.8 5.5 0.4 -0.7 -1.0 2.3
Peak expiratory flow (PEF) 0.2 0.4 1.2 0.2 0.2 -1.1 -0.6
Pulse wave reflection index 1.2 1.5 4.1 -1.2 0.0 -0.7 2.0
Ever highly irritable/argumentative for 2 days 1.0 1.2 3.1 0.0 -1.3 -1.8 -0.4
Loud music exposure frequency 0.1 0.1 0.2 -0.5 -0.4 0.1 -0.1
Qualifications: O levels/GCSEs or equivalent 1.9 3.1 7.2 -2.7 -0.9 -1.7 1.1
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.5 0.0 0.6 -0.7 -0.2
Blood clot in the leg (DVT) 2.8 3.6 8.3 2.1 1.3 0.5 -2.9
Medication: Paracetamol 2.0 3.3 8.4 -2.9 2.0 -0.4 -0.9
Headache pain in last month 1.3 2.3 8.1 -2.9 0.8 -0.4 -0.5
Medication for cholesterol, blood pressure or diabetes 0.3 0.6 1.7 -1.3 -0.6 0.5 -0.1
Glaucoma (self-reported) 1.6 1.9 2.5 -1.6 1.6 1.1 -1.2
Gout (self-reported) 1.7 2.4 6.2 1.8 2.5 0.1 0.4
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 1.3 -0.9 -0.8 0.1 -1.2
Medication: Amlodipine 0.7 1.0 3.2 0.6 -0.5 -0.4 1.8
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.6 -1.1 -1.3 -0.4 0.8
Birth weight 0.4 1.0 3.1 -0.1 0.9 -1.8 -0.0
Chronic bronchitis/emphysema (mother) 1.2 1.4 2.5 -0.8 -1.5 -1.6 0.5
High blood pressure (siblings) 0.7 1.0 1.8 1.4 -0.5 0.7 -1.2
Forced vital capacity (FVC), Best measure 0.4 1.3 4.2 -2.0 0.2 0.3 0.9
Body fat percentage 2.3 9.3 24.7 -1.7 0.7 3.0 -5.0
Leg fat percentage (right) 1.7 6.3 20.8 -0.9 0.5 1.8 -4.6
Arm fat-free mass (right) 0.2 0.9 3.3 -1.8 0.1 -0.7 -0.1
Exposure to tobacco smoke outside home 1.5 2.0 6.1 -0.6 1.2 -2.5 -0.1
Comparative body size at age 10 0.1 0.4 1.2 -1.1 -0.1 0.5 0.4
Number of full brothers 2.2 2.7 5.2 2.3 0.6 1.5 -1.8
Worry too long after embarrassment 0.8 1.3 4.7 -0.0 2.2 -0.6 -0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.1 5.0 1.6 2.2 -0.9 0.4
Wheeze or whistling in the chest in last year 0.3 0.5 1.6 -0.4 -0.3 0.0 -1.3
Number of children fathered 1.5 1.7 5.6 -0.7 0.4 0.7 -2.4
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.9 0.9 0.5 0.5 -0.0
Age at first live birth 1.3 2.3 7.2 0.3 -0.7 1.3 2.7
Pulse wave peak to peak time 1.4 1.6 2.7 1.6 1.6 0.6 -1.0
Health satisfaction 0.8 1.0 2.0 1.4 -0.7 -0.8 -1.0
Shortness of breath walking on level ground 1.7 2.0 7.8 0.1 -0.2 -2.8 0.3
Qualifications: College or University degree 0.7 2.3 6.9 0.9 0.0 1.1 2.6
Eye problems/disorders: None of the above 0.2 0.2 0.5 -0.7 -0.1 0.6 0.2
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.9 -0.9 0.2 0.1 -0.7
Emphysema/chronic bronchitis 0.4 0.4 1.0 -0.6 -0.5 0.5 -1.0
Medication for pain relief, constipation, heartburn 1.4 2.4 3.7 1.9 -1.8 -0.5 1.6
Neck or shoulder pain in last month 0.7 1.0 2.0 -1.4 1.4 -0.2 -0.3
Medication: Blood pressure 0.4 0.7 1.2 1.0 0.7 -0.5 1.1
Angina (self-reported) 1.1 1.4 2.2 -0.2 1.1 1.5 -1.5
Migraine (self-reported) 0.5 0.6 0.9 0.6 0.8 -0.7 -0.9
Medication: Ibuprofen 0.9 1.1 3.7 -1.9 0.3 -0.3 -0.6
Medication: Allopurinol 0.3 0.5 1.3 1.1 0.5 0.3 0.6
Medication: Omeprazole 1.4 1.7 3.0 -0.6 1.7 0.8 -1.7
Medication: Seretide 50 evohaler 1.2 1.4 3.4 -1.0 0.6 0.9 -1.8
Mean time to correctly identify matches 0.2 0.4 0.8 -0.2 0.4 -0.9 0.8
Heart disease (mother) 4.8 5.9 13.0 -1.5 -0.9 2.7 -3.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 2.0 0.7 -0.9 0.1 1.4
Whole body fat mass 1.5 6.3 16.3 -1.9 0.8 2.1 -4.0
Leg fat mass (right) 1.1 4.4 13.5 -1.4 0.7 1.4 -3.7
Arm predicted mass (right) 0.1 0.6 2.1 -1.5 0.1 -0.6 0.2
Pulse rate, automated reading 0.4 1.2 1.9 1.2 -1.0 1.4 -0.6
Alcohol intake frequency. 0.2 0.6 1.8 -0.2 -1.3 0.6 -0.3
Comparative height size at age 10 0.6 3.2 8.0 -1.1 -1.9 0.3 2.8
Number of full sisters 1.1 1.3 2.7 0.0 0.6 1.6 -1.5
Suffer from ‘nerves’ 1.0 1.6 3.8 1.4 1.9 -0.8 0.6
Overall health rating 0.4 0.8 2.9 -0.3 0.3 -0.4 -1.7
Chest pain or discomfort 0.7 1.0 1.9 -0.4 1.4 -0.6 -1.3
Had major operations 0.6 0.7 2.2 1.5 0.4 0.4 -0.5
Age at last live birth 2.3 3.4 7.3 1.0 -2.1 1.0 2.7
Family relationship satisfaction 0.9 1.2 3.2 0.4 1.8 -1.1 -0.2
Leg pain on walking 0.8 1.0 1.8 0.4 1.2 -0.8 -1.3
Qualifications: NVQ or HND or HNC or equivalent 2.7 3.2 10.9 0.6 -0.1 1.3 -3.3
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.8 -0.8 -0.1 -1.7 -0.1
Illness, injury, bereavement, stress in last 2 years 2.6 3.2 5.9 -1.1 -2.3 0.7 2.4
Medication: Aspirin 1.7 2.3 5.2 -0.3 2.3 0.8 -1.8
Supplements: Vitamin C 1.3 1.6 4.0 1.2 0.4 -0.9 2.0
Knee pain experienced in last month 1.1 1.6 3.3 -0.6 1.8 -0.2 -1.7
Hypertension (Self-reported) 0.2 0.7 1.6 -0.7 -0.7 1.2 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.9 -0.9 0.2 0.5 -0.3
Illnesses of father: Heart disease 0.6 0.8 2.1 1.4 0.5 -0.1 -0.9
Illnesses of siblings: Diabetes 0.6 0.8 1.7 -0.8 0.8 -0.2 -1.3
Smoking status: Previous 0.4 0.7 1.2 0.4 1.1 -1.1 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 2.3 -1.3 -1.5 1.2 1.3
Whole body fat-free mass 0.3 1.6 3.0 -1.7 0.4 -1.6 0.7
Leg fat-free mass (right) 0.3 1.7 3.1 -1.8 0.7 -1.7 -0.1
Arm fat percentage (left) 2.1 8.3 24.2 -1.9 1.0 2.2 -4.9
Average weekly red wine intake 0.5 0.7 1.0 1.0 -1.0 -0.9 0.2
Handedness (chirality/laterality): Left-handed 0.9 1.1 2.7 0.8 1.6 1.1 0.1
Mood swings 2.4 4.4 7.7 0.3 2.0 -2.8 -2.4
Loneliness, isolation 1.9 2.7 6.0 0.9 2.5 0.1 -2.0
Long-standing illness, disability or infirmity 0.6 0.8 1.5 -1.2 0.6 -0.3 -1.2
Ever had bowel cancer screening 0.3 0.3 1.0 -0.4 0.1 -0.4 -1.0
Diabetes diagnosed by doctor 0.1 0.2 0.5 0.3 -0.6 0.3 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 3.5 0.7 1.3 -0.9 -1.9
Friendships satisfaction 0.3 0.4 1.1 0.2 0.1 -0.7 1.0
Qualifications: nursing, teaching 0.7 1.1 3.1 0.9 0.7 0.1 1.8
Commuting to job workplace: Walk 0.1 0.1 0.2 0.4 -0.4 0.2 -0.0
Eye problems/disorders: Cataract 0.1 0.2 0.3 0.1 -0.4 -0.5 0.5
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.7 1.3 1.2 -0.2 0.4
Medication for cholesterol 1.1 1.7 6.1 -0.6 0.1 -0.6 2.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.0 -1.0 -0.3 0.2 1.0
Back pain experienced in last month 1.9 2.7 6.6 -0.5 2.6 -1.0 -1.7
Mineral and other dietary supplements 0.9 1.2 1.6 -1.3 -1.0 -0.9 1.1
Breast cancer (self-reported) 0.8 1.0 1.7 0.9 -1.0 -1.3 0.6
Asthma (self-reported) 0.1 0.1 0.3 -0.3 -0.6 0.4 -0.1
Osteoporosis (self-reported) 0.1 0.1 0.3 -0.5 -0.1 0.5 0.3
Osteoarthritis (self-reported) 0.7 0.9 2.5 0.0 1.6 -0.4 -1.0
Medication: Aspirin 1.6 2.0 5.5 -0.4 2.3 0.9 -1.3
Medication: Gliclazide 1.5 1.7 4.7 -2.2 0.2 -0.7 -1.2
Illnesses of father: None of the above (group 1) 1.0 1.2 2.4 -0.3 1.0 -1.6 1.2
Smoking status: Current 1.7 2.7 6.2 -1.2 -1.8 -2.5 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 4.3 1.3 0.8 1.0 -2.1
Whole body water mass 0.2 1.4 2.8 -1.7 0.3 -1.6 0.5
Leg predicted mass (right) 0.3 1.7 3.1 -1.8 0.7 -1.7 -0.1
Arm fat mass (left) 1.5 6.2 17.5 -2.0 0.9 1.5 -4.2
Number of self-reported non-cancer illnesses 1.2 2.1 6.1 -0.6 1.4 0.5 -2.5
Average weekly champagne plus white wine intake 2.3 3.2 8.1 -0.2 0.9 2.0 2.9
Miserableness 2.0 3.5 6.6 -0.8 2.4 -1.0 -2.6
Guilty feelings 0.7 1.1 1.9 0.0 1.4 -0.7 -1.3
Wears glasses or contact lenses 1.0 1.2 3.7 1.9 0.7 0.6 -0.5
Ever taken oral contraceptive pill 1.6 1.8 3.2 -0.3 1.8 -0.9 1.7
Hearing aid user 1.3 1.5 2.4 -0.5 1.6 -1.0 1.5
Mother’s age at death 0.5 0.7 1.3 1.2 0.0 -0.6 1.0
Financial situation satisfaction 0.7 0.9 1.9 -0.9 0.1 -1.4 -0.9
Tinnitus: Yes, now most or all of the time 1.9 2.2 5.9 -2.4 -0.4 -1.6 -0.7
Commuting to job workplace: Public transport 0.6 0.7 1.9 -0.8 -0.3 -0.3 1.4
Eye problems/disorders: Glaucoma 0.9 1.0 1.8 -0.7 1.4 0.9 -1.0
Medication: Blood pressure 1.2 2.3 4.8 0.7 0.1 1.9 -2.2
Pain type(s) experienced in last month: Hip pain 1.3 1.6 5.4 -0.7 0.0 -2.3 -0.7
Supplements: Fish oil (including cod liver oil) 2.0 2.6 3.2 1.3 1.7 1.6 -1.8
High cholesterol (Self-reported) 1.7 3.1 7.3 -1.1 2.7 0.7 -1.8
Medication: Bendroflumethiazide 2.9 4.3 12.0 -0.7 -0.2 3.5 -2.2
Medication: Paracetamol 1.5 2.4 6.9 -2.6 1.3 -0.4 -0.8
Medication: Lisinopril 0.2 0.2 0.5 -0.7 0.2 0.5 -0.2
Medication: Atorvastatin 1.2 1.4 3.7 0.7 0.9 0.9 -1.9
Illnesses of father: High blood pressure 2.7 3.3 7.6 -2.1 -0.1 2.8 -1.2
Alcohol drinker status: Never 2.0 2.3 3.9 0.3 -1.6 2.0 1.7
Ever smoked 0.9 1.6 5.0 0.2 0.7 -2.2 -0.9
Basal metabolic rate 0.2 1.3 3.9 -2.0 0.3 -1.1 -0.1
Leg fat percentage (left) 1.9 6.9 23.3 -0.8 0.4 1.8 -4.8
Arm fat-free mass (left) 0.1 0.6 1.4 -1.2 0.2 -0.9 -0.3
Number of operations (self-reported) 0.3 0.5 0.7 0.8 0.9 0.1 -0.8
Average weekly beer plus cider intake 0.6 0.8 1.5 -0.1 -0.6 -1.2 -1.2
Irritability 1.8 3.0 6.7 0.6 2.6 -0.9 -2.1
Risk taking 1.2 1.8 2.9 -0.5 1.7 -1.3 -1.5
Ever had prostate specific antigen (PSA) test 1.8 2.1 3.9 1.2 -0.4 -2.0 1.7
Fractured/broken bones in last 5 years 2.7 3.5 6.9 0.4 2.4 -1.0 -2.6
Age started oral contraceptive pill 1.6 2.0 3.9 0.5 2.0 1.9 -0.5
Diastolic blood pressure, automated reading 0.7 2.1 7.4 -2.7 -0.5 0.8 -0.2
Ever depressed for a whole week 1.0 1.3 2.2 0.9 1.4 -1.5 -0.0
Unable to work because of sickness or disability 0.4 0.5 1.1 -0.4 0.9 0.1 -1.1
Commuting to job workplace: Cycle 0.9 1.1 2.6 -0.1 -0.1 1.3 -1.6
Myopia 0.4 0.6 1.9 -0.3 -0.2 0.6 1.4
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.6 -0.3 0.1 -0.8 0.8
Cholesterol lowering medication 2.4 3.6 13.0 0.2 0.9 0.8 -3.6
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.9 -0.9 1.7 0.3 -0.2
Pain experienced in last month 1.3 2.2 5.7 2.4 -1.5 0.4 0.8
Supplements: Calcium 0.3 0.3 0.4 -0.4 0.6 -0.6 0.6
Basal cell carcinoma (self-reported) 1.0 1.1 1.8 1.3 1.2 0.3 1.1
Heart attack/myocardial infarction (self-reported) 1.3 1.7 5.4 0.4 1.0 0.4 -2.3
Deep venous thrombosis (DVT) (self-reported) 2.2 2.9 7.1 1.7 1.2 0.3 -2.7
Heart disease (siblings) 2.5 3.0 9.6 0.5 1.3 0.7 -3.1
Alcohol drinker status: Previous 0.1 0.1 0.2 -0.4 0.0 0.4 -0.4
Pack years of smoking 1.3 1.9 4.2 -1.2 0.7 1.2 -2.1
Impedance of whole body 0.7 3.6 13.0 0.5 -1.1 3.6 0.1
Leg fat mass (left) 1.1 4.4 13.8 -1.3 0.6 1.3 -3.7
Arm predicted mass (left) 0.1 0.6 1.6 -1.2 0.1 -0.8 -0.5