Hub : Genes

GALNTL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0800	0.0380	0.0041	0.019	0.012	0.017	NA	0.021	0.026	0.0630	0.034	NA	0.022
2	TCGA	Brain Lower Grade Glioma	0.0583	0.0274	0.0037	0.011	0.021	0.007	NA	0.006	0.017	0.0018	0.049	NA	0.067
3	TCGA	Stomach Adenocarcinoma	0.0930	0.0420	0.0059	0.001	0.017	0.005	NA	0.005	0.240	0.0200	0.140	NA	0.140

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	0.9	1.3	1.1	0.8	1.0
Bipolar Disorder or Schizophrenia	1.3	3.1	5.9	1.6	0.9	2.4
Depressed Affect (Nagel 2018)	0.8	1.7	4.1	-1.0	-2.0	0.1
Depression (Nagel 2018)	1.6	2.4	6.0	-1.0	-2.5	-0.1
Intelligence (Savage-Jansen 2018)	0.7	2.0	3.3	-0.2	1.7	-1.8
Neuroticism (Nagel 2018)	1.0	2.4	3.8	-1.9	-1.8	0.0
Schizophrenia (2018)	1.2	2.4	5.5	1.1	0.7	2.3
Schizophrenia vs Biploar Disorder	1.7	2.3	4.1	0.2	-2.0	1.6
Worry (Nagel 2018)	3.1	6.5	13.7	-3.7	-1.8	-1.6
Alzheimer’s Disease (in mother)	0.5	0.5	1.5	-0.4	1.2	0.1
Alzheimer’s Disease (in father)	0.3	0.4	0.6	0.7	0.3	0.7
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.0	0.5	0.1
Crohns Disease (2017)	2.3	5.0	10.5	-1.3	-1.7	-3.2
Irritable Bowel Disease (IBD)	0.4	1.1	2.3	-0.3	-0.9	-1.5
Ulcerative Colitis (UC)	0.1	0.2	0.3	0.4	0.5	0.5
Major Depression (MDD)	1.1	1.4	3.7	0.6	-0.1	1.9
Reaction Time	0.6	1.2	3.3	1.8	0.3	0.5
Verbal and Numeric Reasoning (VNR)	1.0	2.3	5.9	0.0	1.0	-2.4
Breast Cancer	0.5	1.1	2.2	-0.7	-0.8	-1.5
Ovarian Cancer	1.1	1.4	2.8	0.4	1.7	-1.1
Prostate Cancer	1.2	1.7	3.0	-1.7	0.1	-1.4
Age at First Birth	0.2	0.3	0.5	0.6	0.2	0.7
Bipolar Disorder (2011)	1.2	1.2	1.8	-1.3	0.2	-1.3
Body Mass Index (BMI) (2010)	3.4	4.7	12.9	1.1	-3.6	-0.3
Coronary Artery Disease (CAD)	1.0	1.2	3.2	-0.4	1.8	0.3
Crohns Disease (2012)	0.5	0.8	2.2	0.4	0.1	-1.5
Mean Putamen Volume	0.6	0.7	1.9	-0.2	0.5	1.4
Fasting Glucose	0.5	0.6	1.6	-0.2	0.3	-1.3
HbA1C	0.4	0.5	1.0	-0.1	1.0	0.7
HDL Cholesterol	0.1	0.2	0.3	0.5	-0.5	-0.4
LDL Cholesterol	0.1	0.1	0.2	-0.0	-0.4	0.4
Lupus	0.5	0.7	1.5	-0.3	0.7	1.2
Neuroticism (2016)	0.4	0.6	1.5	-0.4	-0.2	1.2
Primary Biliary Cirrhosis	1.7	2.4	5.2	-1.4	0.0	-2.3
Rheumatoid Arthritis	1.6	2.1	2.8	-1.4	-1.7	-1.4
Schizophrenia (2014)	0.9	1.9	4.7	0.9	0.6	2.2
Triglycerides	0.4	0.7	1.6	-0.2	-1.3	0.6
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	-0.2	-0.2	-0.2
Ulcerative Colitis	0.3	0.4	1.3	0.2	1.1	0.1
Blood Eosinophil Count	0.1	0.7	1.3	1.1	0.7	-0.5
Blood Platelet Count	3.3	38.7	85.2	-0.1	9.2	5.6
Blood Red Count	0.4	3.8	7.9	-2.8	1.5	1.1
Blood White Count	0.3	1.9	4.3	-1.2	2.1	-0.1
Heel T-Score	0.3	2.6	4.1	2.0	1.0	1.7
BMI	1.3	7.4	22.0	0.0	-4.7	-0.3
Height	0.0	0.9	1.5	-0.6	1.2	0.9
Waist Hip Ratio (WHR)	0.1	0.6	0.9	-1.0	-0.8	-0.3
Systolic Blood Pressure	0.7	3.5	5.9	-2.4	0.1	-2.2
Smoking Status	0.4	1.0	1.4	-1.2	-0.9	-0.9
Allergy or Eczema	0.7	1.9	2.9	-0.9	1.4	-1.7
Cardiovascular Disease	1.0	3.3	9.7	0.2	-3.1	-0.4
Hypothyroidism (self reported)	0.0	0.0	0.1	-0.3	0.1	-0.1
Respiratory disease	0.2	0.5	1.1	0.6	1.0	0.3
Type 2 Diabetes (T2D) (2018)	1.5	2.8	6.9	-0.7	-2.6	-1.1
Lung FEV1/FVC ratio	1.2	5.9	8.5	-1.5	-2.9	-2.7
Lung FVC	0.8	4.3	7.1	2.7	0.9	2.2
Neuroticism	2.1	5.1	8.0	-2.7	-2.8	0.1
Chronotype (morning person)	0.1	0.3	0.6	0.3	0.8	0.5
Hair Pigment	0.0	0.1	0.2	0.2	0.1	-0.5
Tanning	0.1	1.1	2.0	0.2	-1.1	1.4
Hand grip strength (left)	1.7	4.4	11.3	-3.4	-0.6	-1.3
Number of treatments/medications taken	1.6	3.0	3.7	-1.5	-1.9	-1.7
Average weekly spirits intake	0.7	0.9	2.1	-1.5	-0.7	0.1
Sensitivity / hurt feelings	3.4	5.8	6.5	-2.5	-2.5	-2.2
Frequency of depressed mood in last 2 weeks	2.0	2.8	8.1	-0.7	-2.8	-0.1
Hearing difficulty/problems: Yes	0.5	0.8	1.4	0.9	-1.2	-0.4
Relative age of first facial hair	0.6	1.3	3.3	0.5	1.8	0.6
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	3.1	1.8	-1.2	-0.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	1.0	0.4	0.3
Ever had hysterectomy (womb removed)	0.4	0.4	1.2	0.1	1.1	0.4
Systolic blood pressure, automated reading	0.7	2.0	3.3	-1.2	1.1	-1.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	0.2	-0.8	0.7
Angina	0.2	0.2	0.5	-0.3	0.4	-0.7
Medication for hormone replacement therapy	0.3	0.4	0.9	-0.0	-1.0	-0.5
Vitamin and mineral supplements	0.3	0.4	1.1	-0.2	-0.0	-1.0
Supplements: Zinc	1.6	1.8	3.7	0.5	1.2	1.9
Medication: Co-codamol	1.9	2.1	4.0	-1.2	-1.0	-2.0
Medication: Metformin	3.0	4.2	11.7	-0.3	-3.4	-1.0
Diabetes (father)	1.3	1.6	4.5	0.4	-2.1	-0.0
Diabetes (mother)	0.3	0.4	1.2	0.1	0.1	1.1
Severe depression (siblings)	0.8	0.9	2.2	1.5	0.6	-0.2
Pack years adult smoking proportion	0.5	0.7	0.8	0.9	-0.7	0.8
Impedance of leg (right)	0.7	3.6	8.0	-2.8	1.6	0.3
Leg fat-free mass (left)	0.3	1.8	5.2	0.3	-2.3	-0.4
Trunk fat percentage	1.7	6.9	18.6	-1.3	-4.3	-0.7
Hand grip strength (right)	0.8	2.3	6.7	-2.6	-0.1	-0.3
Townsend deprivation index at recruitment	0.8	1.2	3.3	0.2	-1.8	-0.4
Current tobacco smoking	1.9	3.1	3.4	-1.8	-1.8	-1.6
Average weekly fortified wine intake	0.5	0.6	1.0	0.5	1.0	0.8
Maternal smoking around birth	1.7	2.5	6.7	-0.4	-2.6	-0.8
Fed-up feelings	1.0	1.7	4.0	-1.1	-2.0	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	4.0	5.3	15.9	-0.2	-4.0	-0.3
Relative age voice broke	1.2	1.8	2.7	1.4	1.6	0.9
Taking other prescription medications	0.7	1.0	1.3	-1.1	-0.7	-1.2
Age when periods started (menarche)	1.0	2.4	3.6	-1.9	0.9	-1.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.5	0.7	-0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.8	0.5	0.9	1.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.2	-0.3	-1.5	-0.6
Qualifications: CSEs or equivalent	0.8	1.1	2.5	-0.7	1.6	-0.4
Serious illness, injury or assault to yourself	2.0	2.4	3.6	-0.5	-1.9	-1.8
High blood pressure	1.1	3.2	9.1	0.6	-3.0	0.2
Hayfever, allergic rhinitis or eczema	2.2	4.9	6.2	-2.2	1.8	-2.5
Multivitamins +/- minerals	0.1	0.1	0.1	-0.2	-0.3	0.4
Stomach or abdominal pain in last month	0.6	0.7	1.7	-0.4	-0.4	-1.3
Supplements: Glucosamine	0.6	0.8	1.9	1.4	0.2	0.7
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	-0.1	0.6	0.1
Medication: Atenolol	0.4	0.5	1.2	0.1	-1.1	-0.5
Medication: Levothyroxine sodium	0.5	0.9	1.8	-1.4	1.0	0.1
Sitting height	0.0	0.3	0.6	-0.7	-0.1	-0.5
Chronic bronchitis/emphysema (father)	4.3	5.0	6.0	-2.5	-1.8	-2.4
High blood pressure (mother)	0.5	0.8	2.2	-1.5	-0.1	-0.1
Body mass index (BMI)	1.2	5.1	15.2	0.1	-3.9	-0.0
Impedance of leg (left)	0.7	3.4	7.2	-2.7	1.6	0.6
Leg predicted mass (left)	0.3	1.8	5.2	0.4	-2.3	-0.3
Trunk fat mass	1.6	7.0	19.8	-1.0	-4.5	-0.3
Waist circumference	1.2	4.5	13.2	-0.4	-3.6	0.1
Number of incorrect matches in round	0.2	0.3	0.6	-0.7	-0.5	0.5
Past tobacco smoking	0.1	0.1	0.2	0.4	-0.1	-0.5
Alcohol usually taken with meals	1.0	1.6	2.4	1.4	1.6	-0.7
Nervous feelings	2.5	4.7	13.9	-3.7	-0.2	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.6	-0.5	-1.3	0.4
Hearing difficulty/problems with background noise	0.4	0.7	1.0	0.4	-1.0	-1.0
Hair/balding pattern: Pattern 2	2.0	2.6	3.3	-1.8	1.6	-1.4
Had menopause	0.2	0.2	0.5	0.3	-0.7	-0.2
Had other major operations	1.2	1.5	1.7	-1.2	1.1	-1.3
Forced vital capacity (FVC)	0.6	2.1	2.8	1.7	0.9	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	4.2	0.4	1.4	2.0
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	3.5	1.8	-1.9	-0.0
Qualifications: None of the above	1.2	2.6	4.1	-1.0	-1.7	2.0
Financial difficulties in last 2 years	0.2	0.3	0.8	-0.2	-0.9	-0.3
Mouth/teeth dental problems	2.6	4.0	7.2	1.9	1.2	2.7
Heart attack	2.2	2.9	5.9	-1.2	-2.4	-1.1
Allergy	0.9	2.0	2.9	1.1	-1.7	1.5
Pain all over the body in last month	1.9	2.0	3.9	-2.0	0.4	-1.4
Diabetes (self-reported)	3.8	5.9	12.5	-0.9	-3.5	-2.1
Hayfever/allergic rhinitis (self-reported)	2.0	2.7	4.6	-1.7	0.7	-2.1
Medication: Ramipril	3.3	4.2	8.9	-1.1	-3.0	-1.6
Medication: Simvastatin	2.3	3.4	5.2	-0.5	-2.3	-2.2
Fluid intelligence score	0.9	1.8	3.1	0.9	1.8	-1.2
Illnesses of siblings	1.8	2.5	5.8	-0.2	2.4	1.3
Neuroticism score	2.3	4.8	7.1	-2.7	-2.7	-0.4
Weight	0.7	3.5	10.4	-0.3	-3.2	-0.0
Impedance of arm (right)	0.4	1.9	3.2	-1.8	1.3	-0.9
Arm fat percentage (right)	1.9	7.4	20.4	-1.0	-4.5	-0.8
Trunk fat-free mass	0.1	0.6	1.8	0.3	-1.3	0.1
Hip circumference	0.7	3.0	8.7	-0.4	-2.9	-0.4
Time employed in main current job	1.2	1.4	3.4	-1.9	-0.1	-0.9
Alcohol intake versus 10 years previously	0.4	0.6	1.1	-0.6	-1.0	-0.5
Father’s age at death	0.6	0.8	2.1	-0.1	1.4	0.6
Worrier / anxious feelings	3.1	5.8	13.6	-3.7	-1.6	-1.1
Frequency of tiredness / lethargy in last 2 weeks	5.9	9.6	11.1	-3.3	-3.2	-2.7
Falls in the last year	0.1	0.2	0.3	0.4	0.5	-0.2
Hair/balding pattern: Pattern 3	1.8	2.7	7.0	0.4	-2.7	1.0
Number of live births	0.3	0.5	1.1	-1.0	0.6	-0.0
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.5	1.2	0.5	1.0
Pulse rate	2.1	3.5	4.9	-1.1	-2.2	-2.1
Happiness	0.8	1.0	2.5	1.6	-0.2	0.7
Noisy workplace	0.5	0.6	1.3	-1.1	-0.5	-0.7
Qualifications: A levels/AS levels or equivalent	1.7	3.7	7.8	2.8	1.5	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.8	1.4	0.7	0.5
Mouth/teeth dental problems: Dentures	2.7	4.6	7.9	-1.6	-1.9	-2.8
Asthma	0.3	0.6	1.8	0.1	1.3	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	-0.7	0.1	-0.7
Medication: Cholesterol lowering	2.0	3.1	8.1	-1.0	-2.8	-0.4
Depression (self-reported)	0.9	1.1	2.3	0.9	-1.5	-0.2
Medication: Lansoprazole	3.8	4.4	10.8	-3.3	-1.3	-0.8
Prospective memory result	3.4	4.1	5.8	-2.4	-2.3	-1.1
Lung cancer (father)	0.4	0.5	0.9	-1.0	-0.8	-0.1
Illnesses of mother	1.4	1.8	4.2	2.0	-1.0	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.7	0.2	0.8	0.4
Pulse wave Arterial Stiffness index	1.5	1.7	4.5	-0.8	-2.1	0.0
Impedance of arm (left)	0.4	1.7	3.6	-1.1	1.9	-0.4
Arm fat mass (right)	1.4	5.6	16.6	-0.3	-4.1	-0.1
Trunk predicted mass	0.1	0.6	1.7	0.4	-1.3	0.2
Standing height	0.0	0.5	1.0	-0.6	1.0	0.1
Length of working week for main job	0.7	0.8	1.2	-0.3	-1.0	-1.1
Exposure to tobacco smoke at home	0.8	0.9	2.4	0.6	-1.5	0.2
Breastfed as a baby	0.1	0.1	0.3	-0.2	0.5	0.2
Tense / ‘highly strung’	0.6	1.0	2.3	-0.4	-1.5	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.6	-1.3	-0.1	-0.8
Hair/balding pattern: Pattern 4	1.4	3.5	6.3	1.1	-1.7	-2.5
Birth weight of first child	0.4	0.7	1.1	0.8	1.1	0.6
Peak expiratory flow (PEF)	0.2	0.5	0.9	0.7	-1.0	0.0
Pulse wave reflection index	0.2	0.3	0.8	0.3	-0.0	0.9
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.7	-0.4	-2.2	0.6
Loud music exposure frequency	0.1	0.1	0.2	0.4	-0.2	-0.4
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	4.0	1.8	2.0	0.6
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	3.3	-1.4	-1.8	-1.2
Blood clot in the leg (DVT)	0.2	0.3	0.7	0.2	0.1	0.9
Medication: Paracetamol	0.5	0.8	1.4	-1.2	-0.9	-0.3
Headache pain in last month	1.5	2.6	5.7	-2.4	-1.2	-0.6
Medication for cholesterol, blood pressure or diabetes	1.4	2.2	6.5	0.3	2.5	0.4
Glaucoma (self-reported)	0.4	0.4	1.2	-0.4	1.1	-0.1
Gout (self-reported)	0.6	0.9	2.2	-0.6	0.0	-1.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.2	-0.7	1.1	-0.2
Medication: Amlodipine	3.0	4.2	11.4	1.0	-3.4	-0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	0.8	0.1	0.4
Birth weight	0.1	0.1	0.3	0.0	0.2	0.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.7	1.3	-0.6	0.7
High blood pressure (siblings)	1.4	1.9	5.2	0.5	-2.3	-0.6
Forced vital capacity (FVC), Best measure	0.3	1.2	1.8	0.6	1.3	1.3
Body fat percentage	1.9	7.3	20.1	-1.3	-4.5	-0.4
Leg fat percentage (right)	1.8	6.4	17.5	-1.3	-4.2	0.3
Arm fat-free mass (right)	0.2	1.0	2.4	0.6	-1.5	0.6
Exposure to tobacco smoke outside home	1.8	2.4	6.8	-0.6	-2.6	0.1
Comparative body size at age 10	2.5	7.0	17.2	2.0	-4.2	0.1
Number of full brothers	1.1	1.4	3.2	-1.8	-0.5	0.8
Worry too long after embarrassment	0.2	0.3	0.4	-0.6	-0.4	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.3	-1.0	-0.3
Wheeze or whistling in the chest in last year	0.5	0.9	1.4	0.7	-1.2	-0.8
Number of children fathered	0.4	0.5	0.7	-0.7	0.6	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.0	0.7	-0.5	-1.4
Age at first live birth	0.1	0.2	0.6	0.8	-0.3	0.1
Pulse wave peak to peak time	1.6	1.9	5.1	0.7	2.3	0.0
Health satisfaction	0.9	1.2	2.8	0.5	-1.7	-0.7
Shortness of breath walking on level ground	0.8	0.9	1.7	1.0	-1.3	0.1
Qualifications: College or University degree	1.1	3.6	7.3	2.7	1.9	0.0
Eye problems/disorders: None of the above	0.5	0.5	1.3	1.1	-0.4	-0.3
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.1	-0.6	-0.9	-1.8
Emphysema/chronic bronchitis	1.9	2.1	5.1	1.0	-2.3	0.4
Medication for pain relief, constipation, heartburn	0.7	1.3	2.8	1.7	0.9	0.5
Neck or shoulder pain in last month	0.7	1.0	2.6	-0.6	-1.6	-0.3
Medication: Blood pressure	1.8	3.2	9.6	-0.1	-3.1	-0.1
Angina (self-reported)	0.2	0.3	0.6	-0.5	0.3	-0.8
Migraine (self-reported)	1.0	1.2	3.1	-1.8	-0.1	-0.8
Medication: Ibuprofen	0.2	0.3	0.5	-0.7	0.6	0.1
Medication: Allopurinol	0.7	1.0	1.6	-1.2	-0.2	-1.1
Medication: Omeprazole	0.5	0.6	1.1	1.1	-0.5	-0.7
Medication: Seretide 50 evohaler	1.4	1.6	2.3	1.4	-1.5	0.6
Mean time to correctly identify matches	1.1	2.0	5.5	2.4	-0.4	0.6
Heart disease (mother)	0.0	0.0	0.0	-0.1	-0.1	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.2	1.1	0.2	0.3
Whole body fat mass	1.7	7.2	20.2	-1.1	-4.5	-0.4
Leg fat mass (right)	1.7	6.5	18.9	-0.8	-4.3	0.3
Arm predicted mass (right)	0.3	1.7	4.1	0.7	-2.0	0.6
Pulse rate, automated reading	0.9	2.8	5.2	-1.2	-2.3	-1.3
Alcohol intake frequency.	1.8	4.2	6.6	1.7	-2.6	1.8
Comparative height size at age 10	0.1	0.3	0.9	0.3	-0.1	0.9
Number of full sisters	1.9	2.3	4.1	0.9	-1.5	2.0
Suffer from ‘nerves’	4.6	7.2	12.0	-3.5	-0.4	-3.1
Overall health rating	1.8	3.9	11.1	-0.6	-3.3	-0.5
Chest pain or discomfort	0.8	1.1	1.8	-1.3	-1.0	-0.8
Had major operations	0.4	0.5	1.3	0.2	-1.1	-0.2
Age at last live birth	0.1	0.1	0.2	-0.1	0.5	0.0
Family relationship satisfaction	0.1	0.2	0.3	0.4	0.5	0.2
Leg pain on walking	1.9	2.4	3.1	-1.5	-1.3	-1.8
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	-0.1	-0.4	0.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.1	0.4	-0.8	-1.4
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.9	-0.1	2.0	0.7
Medication: Aspirin	1.6	2.1	6.0	-0.5	-2.4	0.5
Supplements: Vitamin C	0.4	0.5	0.8	0.9	0.4	0.7
Knee pain experienced in last month	2.8	4.3	8.2	-2.1	-2.9	-0.3
Hypertension (Self-reported)	1.3	3.6	10.1	0.8	-3.2	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	5.2	-0.5	0.4	-2.3
Illnesses of father: Heart disease	1.1	1.6	3.7	1.0	-1.9	0.1
Illnesses of siblings: Diabetes	0.6	0.8	1.6	-0.9	-1.3	0.2
Smoking status: Previous	0.2	0.2	0.3	-0.5	0.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.7	-1.6	-0.3	-0.9
Whole body fat-free mass	0.2	1.1	3.2	0.4	-1.8	0.0
Leg fat-free mass (right)	0.3	1.4	3.8	0.6	-2.0	-0.2
Arm fat percentage (left)	1.5	5.8	17.1	-0.5	-4.1	-0.4
Average weekly red wine intake	1.9	2.7	7.4	2.7	0.3	0.8
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.4	-0.5	0.6	-0.3
Mood swings	3.2	5.8	12.5	-2.1	-3.5	-0.7
Loneliness, isolation	1.4	1.9	3.9	-0.2	-2.0	1.3
Long-standing illness, disability or infirmity	1.3	2.0	2.5	-1.1	-1.5	-1.6
Ever had bowel cancer screening	0.3	0.3	0.5	0.2	-0.7	-0.6
Diabetes diagnosed by doctor	4.6	7.5	15.7	-1.3	-4.0	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.7	1.3	-0.7	0.0
Friendships satisfaction	0.5	0.7	1.3	1.2	-0.7	0.4
Qualifications: nursing, teaching	2.1	3.2	9.6	3.1	0.3	0.1
Commuting to job workplace: Walk	1.3	1.4	2.2	-1.0	-1.0	-1.5
Eye problems/disorders: Cataract	0.0	0.1	0.1	0.1	0.2	0.4
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	4.1	0.5	1.5	2.0
Medication for cholesterol	1.9	2.8	4.0	0.9	2.0	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.0	0.1	1.0	0.6
Back pain experienced in last month	0.9	1.3	2.3	-1.5	-1.0	-0.8
Mineral and other dietary supplements	1.9	2.6	4.8	-1.7	0.5	-2.2
Breast cancer (self-reported)	3.0	3.6	7.5	-2.7	-1.2	-1.4
Asthma (self-reported)	0.3	0.6	1.8	0.2	1.3	0.2
Osteoporosis (self-reported)	0.9	1.1	1.8	1.2	1.4	0.2
Osteoarthritis (self-reported)	1.2	1.5	4.4	0.4	-2.1	-0.1
Medication: Aspirin	1.2	1.6	4.3	-0.6	-2.1	0.4
Medication: Gliclazide	0.7	0.8	2.1	0.2	-1.4	-0.5
Illnesses of father: None of the above (group 1)	2.0	2.4	4.5	-0.8	2.1	-1.4
Smoking status: Current	1.7	2.7	3.3	-1.6	-1.8	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.5	-0.8	-1.0	-1.2
Whole body water mass	0.2	1.2	3.6	0.4	-1.9	0.1
Leg predicted mass (right)	0.3	1.5	4.0	0.8	-2.0	-0.2
Arm fat mass (left)	1.1	4.5	13.5	-0.4	-3.7	0.1
Number of self-reported non-cancer illnesses	1.4	2.4	3.6	-1.2	-1.5	-1.9
Average weekly champagne plus white wine intake	2.0	2.8	7.1	0.1	1.2	-2.7
Miserableness	0.4	0.7	1.3	-0.8	-1.2	-0.4
Guilty feelings	1.1	1.7	3.3	-1.2	-0.6	1.8
Wears glasses or contact lenses	0.7	0.8	2.5	0.0	1.6	0.1
Ever taken oral contraceptive pill	0.4	0.4	0.8	-0.4	-0.9	-0.5
Hearing aid user	0.1	0.2	0.2	0.2	0.5	-0.4
Mother’s age at death	1.7	2.1	5.8	-0.6	2.4	0.3
Financial situation satisfaction	0.2	0.2	0.5	-0.1	-0.5	0.7
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.8	-0.9	0.7	-0.5
Commuting to job workplace: Public transport	0.9	1.1	1.3	0.9	1.0	1.1
Eye problems/disorders: Glaucoma	1.0	1.1	3.1	-0.5	1.8	0.2
Medication: Blood pressure	0.3	0.6	1.1	-0.3	-1.0	-0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.3	-0.0	-1.1	-0.1
Supplements: Fish oil (including cod liver oil)	2.6	3.4	8.0	1.4	0.3	2.8
High cholesterol (Self-reported)	1.4	2.5	5.5	-0.2	-2.4	-1.4
Medication: Bendroflumethiazide	1.0	1.5	3.4	-0.7	-1.8	-0.7
Medication: Paracetamol	0.2	0.4	1.0	-1.0	-0.3	0.2
Medication: Lisinopril	0.5	0.7	1.0	0.9	-1.0	-0.5
Medication: Atorvastatin	0.6	0.7	1.5	0.8	-1.2	0.0
Illnesses of father: High blood pressure	0.2	0.2	0.4	-0.5	0.7	0.1
Alcohol drinker status: Never	1.2	1.5	2.6	0.3	-1.6	1.4
Ever smoked	0.4	0.7	1.5	-1.2	0.5	-0.5
Basal metabolic rate	0.3	1.6	4.9	0.1	-2.2	0.0
Leg fat percentage (left)	1.6	5.9	16.1	-1.1	-4.0	0.6
Arm fat-free mass (left)	0.2	1.3	3.7	0.1	-1.9	0.3
Number of operations (self-reported)	0.3	0.5	1.1	-0.6	0.0	-1.1
Average weekly beer plus cider intake	1.6	2.3	3.4	-1.9	-1.5	-1.1
Irritability	0.8	1.4	2.3	0.4	-1.3	1.5
Risk taking	0.6	0.9	2.1	0.7	-1.5	0.3
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.8	1.4	-0.5	0.1
Fractured/broken bones in last 5 years	0.2	0.3	0.7	0.2	0.2	0.9
Age started oral contraceptive pill	1.7	2.2	3.2	1.8	1.2	1.4
Diastolic blood pressure, automated reading	0.2	0.6	1.6	-1.3	0.3	-0.2
Ever depressed for a whole week	1.3	1.6	4.8	0.3	-2.2	-0.2
Unable to work because of sickness or disability	1.4	1.9	5.5	0.0	-2.4	-0.3
Commuting to job workplace: Cycle	0.5	0.6	1.4	0.5	1.2	0.2
Myopia	2.3	3.3	8.7	-0.0	-3.0	-1.1
Vascular/heart problems diagnosed by doctor	1.2	3.2	9.4	0.2	3.1	0.5
Cholesterol lowering medication	2.1	3.1	5.9	-0.2	-1.9	-2.4
Medication: Omeprazole (e.g. Zanprol)	2.5	3.0	7.0	-0.1	-1.4	-2.7
Pain experienced in last month	1.9	3.1	5.1	2.0	2.2	0.4
Supplements: Calcium	0.5	0.6	1.7	0.0	-0.1	1.3
Basal cell carcinoma (self-reported)	0.0	0.0	0.1	-0.1	0.1	0.2
Heart attack/myocardial infarction (self-reported)	2.2	2.9	6.8	-0.9	-2.6	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	0.1	0.2	0.9
Heart disease (siblings)	1.5	1.9	3.4	1.4	-1.8	-0.6
Alcohol drinker status: Previous	2.4	2.7	4.4	1.8	-2.1	0.6
Pack years of smoking	0.9	1.3	1.8	1.4	-0.8	1.2
Impedance of whole body	0.6	2.8	4.3	-2.1	2.0	-0.4
Leg fat mass (left)	1.6	6.3	18.4	-0.6	-4.3	0.4
Arm predicted mass (left)	0.3	1.7	4.7	0.4	-2.2	0.4