TWAS hub - GCNT2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0680	0.0250	4.1e-03	0.033	0.001	0.008	0.003	0.007	6.0e-05	2.3e-01	3.5e-02	0.14	3.8e-02
2	GTEx	Cells EBV-transformed lymphocytes	0.3430	0.1110	9.4e-03	0.091	NA	0.099	NA	0.106	6.9e-04	NA	4.0e-04	NA	2.6e-04
3	GTEx	Testis	0.6170	0.0800	1.4e-04	0.254	NA	0.237	NA	0.220	1.2e-11	NA	6.8e-11	NA	3.9e-10
4	TCGA	Breast Invasive Carcinoma	0.0357	0.0159	1.8e-03	0.016	0.010	0.008	NA	0.007	2.7e-04	2.8e-03	8.4e-03	NA	1.0e-02
5	TCGA	Prostate Adenocarcinoma	0.1533	0.0399	3.1e-10	0.039	0.085	0.107	NA	0.093	5.3e-05	3.3e-09	2.8e-11	NA	6.1e-10
6	TCGA	Thyroid Carcinoma	0.1720	0.0490	1.8e-09	0.049	0.101	0.096	NA	0.075	1.5e-05	4.6e-10	1.3e-09	NA	8.4e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Commuting to job workplace: Public transport	3.3	3.9	5.9	-2.1	-2.0	-2.4	1.6	-1.8	1.8
Had other major operations	2.8	3.4	8.9	3.0	1.8	-1.7	-0.5	2.2	-0.6
Alzheimer’s Disease (in father)	2.7	2.9	6.8	-2.6	-2.4	2.1	-0.5	0.1	-0.6
Schizophrenia vs Biploar Disorder	2.5	3.3	9.8	-1.4	-1.4	0.1	1.0	-3.1	2.3
Pulse wave peak to peak time	2.5	2.9	6.5	-0.6	-1.2	-2.5	0.7	-1.6	2.5
Pulse wave Arterial Stiffness index	2.4	2.8	6.8	0.4	1.1	2.6	-0.6	1.6	-2.4
Birth weight of first child	2.3	4.1	9.0	-3.0	-2.4	1.8	-1.1	-2.4	-0.2
Pulse rate	2.2	3.8	8.2	2.9	0.4	0.5	-2.4	2.6	-1.2
Father’s age at death	2.1	2.8	5.7	2.4	2.4	1.2	0.3	1.8	-0.7
Alcohol intake versus 10 years previously	2.0	3.0	5.6	2.4	2.0	-1.4	-1.9	1.0	-1.3
Alcohol drinker status: Previous	2.0	2.3	4.9	-1.6	-1.5	2.2	0.9	-1.0	1.5
Birth weight	1.9	4.0	13.0	-3.6	-2.4	2.3	0.1	-0.1	0.4
Smoking status: Previous	1.8	2.7	5.7	0.3	-1.0	-2.4	2.1	-2.3	-0.1
Blood White Count	1.7	12.7	43.7	6.6	3.7	0.2	-1.5	3.5	-2.0
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.7	0.8	-0.0	-1.1	-1.9	1.5	-1.8
Knee pain experienced in last month	1.7	2.7	8.9	1.6	1.4	-1.5	-0.2	3.0	0.5
Mouth/teeth dental problems: Mouth ulcers	1.7	2.8	6.5	-2.6	-2.1	1.5	-1.5	-1.1	0.0
Guilty feelings	1.7	2.6	8.4	-0.6	-1.6	0.0	-1.2	1.5	-2.9
Fractured/broken bones in last 5 years	1.7	2.2	4.6	2.1	1.5	-1.1	1.4	0.6	1.7
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	3.1	-1.7	-1.7	-1.5	1.5	-1.0	0.8
Had menopause	1.6	2.0	7.4	0.6	2.7	0.2	0.6	1.8	-0.6
Length of working week for main job	1.6	1.8	4.2	1.4	1.1	-2.1	-0.2	0.5	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	10.5	-2.0	-3.2	1.2	-1.9	-0.4	-0.6
Stomach or abdominal pain in last month	1.5	1.9	4.1	-0.7	-2.0	1.8	-0.8	-0.1	-1.7
Peak expiratory flow (PEF)	1.5	3.6	12.2	-1.6	-3.5	0.2	-1.7	1.1	-1.6
Health satisfaction	1.5	1.9	4.8	-0.9	-2.2	-1.6	0.4	1.6	-0.8
Time employed in main current job	1.4	1.6	6.3	1.1	0.8	-2.5	-0.7	-0.2	-0.8
Breastfed as a baby	1.4	1.8	5.7	-0.5	-0.2	-0.3	-1.5	2.4	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.9	1.7	0.3	-1.7	-0.5	1.7	-0.2
Angina	1.3	1.7	4.0	0.9	-0.2	0.5	1.9	-1.1	2.0
Pain all over the body in last month	1.3	1.4	2.5	-1.5	-1.6	0.2	1.4	-0.8	1.0
Pulse wave reflection index	1.3	1.6	5.4	-2.3	-1.1	-0.3	0.8	-1.1	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.8	1.4	1.2	-1.1	-0.7	2.0	0.2
Shortness of breath walking on level ground	1.3	1.5	3.7	-0.8	-1.8	-1.9	0.4	-0.6	-0.9
Angina (self-reported)	1.3	1.7	3.9	0.6	-0.5	0.6	2.0	-1.1	2.0
Overall health rating	1.3	2.8	5.8	-1.5	-2.4	-0.5	2.4	-1.2	1.1
Miserableness	1.3	2.2	7.0	-2.6	-1.5	0.4	1.4	1.4	0.4
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.2	0.9	0.0	-1.4	-1.8	0.1	-1.7
Alzheimer’s Disease (in mother)	1.2	1.5	3.6	0.7	-0.0	-1.0	-1.9	0.9	-1.7
Alzheimer’s Disease (including proxy)	1.2	1.8	2.8	-1.7	-1.6	0.1	-1.6	-0.3	-1.7
HbA1C	1.2	1.4	3.8	1.8	2.0	-0.6	-0.6	0.6	0.3
HDL Cholesterol	1.2	2.0	4.6	-1.0	-0.7	-0.9	-2.1	1.8	-1.3
Past tobacco smoking	1.2	2.1	9.4	-0.7	1.0	3.1	-0.8	0.9	0.7
Worry too long after embarrassment	1.2	2.0	5.4	-2.3	-2.2	-0.2	0.3	-0.2	-1.3
Medication: Omeprazole	1.2	1.4	3.8	-0.1	0.1	0.2	-1.0	2.0	-1.9
Chest pain or discomfort	1.2	1.7	6.1	0.6	-0.4	0.6	1.5	-2.5	1.1
Long-standing illness, disability or infirmity	1.2	1.8	5.7	-0.4	-1.2	-0.4	1.1	-1.4	2.4
Medication: Atorvastatin	1.2	1.4	4.4	-2.1	-1.5	1.1	-0.6	0.5	-0.3
Number of operations (self-reported)	1.2	1.8	4.8	1.5	0.8	-0.3	-2.2	1.3	-1.0
Irritability	1.2	2.0	4.8	-2.2	-1.9	0.7	1.8	-0.3	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	5.3	0.1	0.6	-0.5	-1.4	2.3	-1.1
Coronary Artery Disease (CAD)	1.1	1.4	3.0	1.7	1.5	0.1	0.5	1.1	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	6.6	-1.3	0.4	2.6	0.3	-2.1	1.4
Serious illness, injury or assault to yourself	1.1	1.3	3.4	0.2	-0.4	-1.2	1.8	-0.7	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.6	6.2	-0.5	-0.3	0.7	-0.2	2.5	-1.7
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	10.2	-2.7	-3.2	0.7	-1.8	1.0	-0.5
Medication: Lansoprazole	1.1	1.3	3.1	0.9	1.8	-1.1	0.7	1.2	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.8	6.0	-0.8	-0.4	1.0	1.6	0.4	2.4
Commuting to job workplace: Walk	1.1	1.2	2.6	-1.6	-0.5	-1.0	1.5	0.8	0.5
Osteoporosis (self-reported)	1.1	1.4	3.8	1.8	2.0	-0.2	0.7	0.5	-0.4
Medication: Gliclazide	1.1	1.3	4.8	0.1	-0.8	-2.2	1.3	0.5	-0.4
Age started oral contraceptive pill	1.1	1.4	4.5	-0.9	-0.0	0.2	2.1	-1.1	1.3
Major Depression (MDD)	1.0	1.3	2.1	-1.5	-1.4	-1.3	0.7	0.0	1.2
Primary Biliary Cirrhosis	1.0	1.4	4.7	-1.6	-0.8	-0.3	0.4	0.5	2.2
Waist Hip Ratio (WHR)	1.0	4.4	12.5	3.5	2.2	-2.6	0.8	1.3	-0.1
Hearing difficulty/problems: Yes	1.0	1.5	2.9	-0.9	-1.4	1.7	0.9	-1.2	1.1
Vitamin and mineral supplements	1.0	1.3	5.3	0.9	0.6	-0.1	-0.8	2.3	-0.8
Relative age voice broke	1.0	1.5	3.9	-0.7	-1.1	0.5	1.4	-2.0	1.2
Taking other prescription medications	1.0	1.6	3.4	-0.2	-1.0	-0.4	1.8	-1.3	1.9
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	4.1	2.0	0.5	-1.5	0.1	-0.1	-0.9
Depression (self-reported)	1.0	1.2	5.7	-0.0	0.4	-0.6	0.9	2.4	0.5
Ever highly irritable/argumentative for 2 days	1.0	1.2	5.2	0.8	-0.4	-2.3	-0.3	1.2	0.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.7	4.1	2.0	1.7	-0.4	-0.8	1.4	-0.4
Number of full brothers	1.0	1.3	3.0	0.6	0.2	1.4	0.7	-1.3	1.7
Number of children fathered	1.0	1.1	3.1	1.8	0.6	0.1	-0.1	1.8	-0.3
Medication: Seretide 50 evohaler	1.0	1.1	1.8	-1.2	-1.3	-0.4	-1.3	1.2	-0.1
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.1	1.3	-0.1	0.4	-1.4	-0.2	-1.8
Back pain experienced in last month	1.0	1.4	4.2	-1.2	-0.2	0.5	2.0	-1.6	0.4
Illnesses of father: None of the above (group 1)	1.0	1.3	4.1	0.6	0.1	-1.0	1.3	-2.0	-0.6
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.6	1.6	1.5	-1.0	-0.5	0.6	-0.7
Medication: Lisinopril	1.0	1.2	3.1	1.8	1.8	-0.0	0.8	0.6	-0.5
Commuting to job workplace: Cycle	1.0	1.3	2.5	0.3	1.4	0.2	1.6	0.9	1.4
BMI	0.9	5.0	15.9	-4.0	-3.0	0.3	0.5	-1.9	1.0
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	4.4	-0.2	-0.2	2.1	-1.2	-0.6	-0.1
Medication: Co-codamol	0.9	1.0	3.9	0.3	0.4	-1.2	-0.1	0.6	2.0
Forced vital capacity (FVC)	0.9	3.5	9.4	-2.5	-3.1	0.1	-1.8	1.4	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	6.5	-1.8	-0.3	2.5	-0.1	-1.6	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	7.5	-2.2	-2.7	1.8	-1.3	0.7	0.4
Chronic bronchitis/emphysema (mother)	0.9	1.1	3.6	-1.9	-1.7	0.4	-0.3	0.2	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.1	-1.2	-1.1	0.5	-0.6	1.4	1.3
Medication: Ibuprofen	0.9	1.1	2.6	-0.2	-1.4	-1.2	0.1	-1.6	-0.7
Mean time to correctly identify matches	0.9	1.7	3.3	-1.2	0.5	1.8	1.6	-0.8	1.3
Arm predicted mass (right)	0.9	4.5	14.7	-3.8	-2.9	0.1	0.3	-1.5	1.1
Ever had bowel cancer screening	0.9	1.0	2.0	0.4	1.0	-1.4	-1.0	1.3	-0.6
Eye problems/disorders: Cataract	0.9	1.1	2.5	1.4	1.6	-1.2	-0.6	0.5	0.2
Supplements: Fish oil (including cod liver oil)	0.9	1.2	4.7	-0.9	-0.9	-0.5	0.2	-2.2	0.8
Arm fat-free mass (left)	0.9	4.6	16.4	-4.0	-3.0	0.8	0.0	-1.0	0.9
Supplements: Calcium	0.9	1.0	3.3	0.5	1.5	1.8	0.4	0.4	-0.2
Arm predicted mass (left)	0.9	4.6	15.8	-4.0	-3.0	0.7	0.0	-1.3	0.9
Depression (Nagel 2018)	0.8	1.2	4.1	-0.4	0.7	-1.4	-0.0	2.0	-0.7
Hand grip strength (left)	0.8	2.1	5.0	-2.2	-1.4	1.2	-0.5	-0.8	1.7
Ever used hormone-replacement therapy (HRT)	0.8	1.0	3.0	-0.1	1.7	0.6	1.6	0.7	-0.1
Townsend deprivation index at recruitment	0.8	1.1	2.9	1.1	0.1	-1.2	0.7	-0.7	1.7
Age when periods started (menarche)	0.8	2.0	8.4	0.3	-0.3	2.9	0.1	-1.8	0.7
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.2	-1.5	-1.5	0.8	-0.2	-0.7	-0.4
Heart attack	0.8	1.1	4.1	2.0	0.4	0.4	0.4	1.2	0.6
Trunk fat-free mass	0.8	4.4	11.9	-3.5	-3.4	0.6	-0.3	-1.3	0.8
Happiness	0.8	0.9	2.4	-1.1	-1.6	1.4	0.1	0.3	0.2
Noisy workplace	0.8	1.0	3.6	0.9	0.5	-1.9	0.7	-0.6	0.8
Impedance of arm (left)	0.8	3.7	15.6	4.0	1.9	-0.0	0.4	0.5	-1.6
Exposure to tobacco smoke at home	0.8	0.9	3.2	0.8	-0.0	0.1	-0.0	1.3	-1.8
Medication: Amlodipine	0.8	1.1	2.4	-1.6	-0.7	1.4	1.0	0.6	0.2
Forced vital capacity (FVC), Best measure	0.8	2.7	6.1	-1.9	-2.5	1.8	-1.6	1.2	0.2
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.0	0.6	0.5	-0.3	-1.4	1.3	-1.2
Migraine (self-reported)	0.8	1.0	2.8	0.9	0.3	1.7	-0.8	1.2	0.2
Medication: Aspirin	0.8	1.1	2.2	0.7	1.3	-0.3	1.3	-1.5	0.7
Whole body fat-free mass	0.8	4.4	13.0	-3.6	-3.4	0.1	-0.2	-1.3	0.7
Loneliness, isolation	0.8	1.1	2.6	-1.6	-1.3	0.8	0.8	-0.8	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.5	-1.6	-1.1	-0.9	1.2	-0.1	0.4
Whole body water mass	0.8	4.5	13.6	-3.7	-3.3	0.2	-0.1	-1.3	0.8
Alcohol drinker status: Never	0.8	0.9	1.4	-0.9	-1.0	0.7	-1.2	-1.1	-0.7
Ever smoked	0.8	1.4	5.4	1.4	-0.2	-2.3	-0.1	0.7	-0.7
Basal metabolic rate	0.8	4.6	13.7	-3.7	-3.3	0.2	0.1	-1.5	0.7
Unable to work because of sickness or disability	0.8	1.0	3.1	1.8	1.4	-0.7	0.7	0.2	-0.2
Heart attack/myocardial infarction (self-reported)	0.8	1.1	4.3	2.1	0.5	0.3	0.5	1.0	0.8
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.9	0.9	0.7	1.7	0.3	-1.3	0.4
Impedance of whole body	0.8	4.1	16.8	4.1	2.5	0.2	0.5	0.7	-1.1
Ovarian Cancer	0.7	0.9	2.1	0.3	1.0	-0.4	1.4	-0.1	1.4
Age at First Birth	0.7	1.0	2.7	1.4	1.6	-0.2	0.1	0.9	-0.7
Ulcerative Colitis	0.7	1.0	2.8	0.3	-0.0	-0.2	1.7	-1.2	1.2
Blood Eosinophil Count	0.7	5.0	17.1	4.1	3.1	-0.7	1.3	0.9	-0.1
Chronotype (morning person)	0.7	1.7	6.6	-2.6	-1.7	0.2	0.2	-0.6	0.5
Medication: Levothyroxine sodium	0.7	1.2	2.7	-0.6	-1.1	1.0	-0.3	-1.6	1.4
Body mass index (BMI)	0.7	3.1	11.4	-3.4	-2.0	-0.1	0.4	-1.6	0.7
Leg predicted mass (left)	0.7	3.6	10.7	-3.3	-3.0	-0.4	0.3	-1.2	0.4
Fluid intelligence score	0.7	1.4	3.1	1.8	1.0	1.2	1.2	-1.0	0.5
Weight	0.7	3.7	10.7	-3.3	-2.6	0.1	0.9	-1.8	0.8
Impedance of arm (right)	0.7	3.3	12.8	3.6	1.3	0.1	-0.1	1.0	-2.1
Hip circumference	0.7	3.2	12.0	-3.5	-2.2	0.0	0.7	-0.9	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.7	0.0	-0.5	-0.9	1.0	-0.4	1.6
Trunk predicted mass	0.7	4.3	11.7	-3.4	-3.4	0.6	-0.4	-1.2	0.7
Arm fat-free mass (right)	0.7	3.8	13.1	-3.6	-2.7	-0.0	0.1	-1.2	1.0
Comparative body size at age 10	0.7	1.9	5.2	-2.3	-1.1	-0.9	1.8	-0.3	0.9
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	3.3	0.8	1.8	0.0	-1.1	0.3	0.1
Qualifications: nursing, teaching	0.7	1.2	2.6	-1.5	0.0	1.6	0.4	1.1	-0.8
Medication: Aspirin	0.7	0.9	1.8	0.8	1.3	-0.1	0.9	-1.3	0.5
Average weekly champagne plus white wine intake	0.7	1.0	4.8	-0.4	-0.4	-0.6	0.0	0.6	-2.2
Mother’s age at death	0.7	0.9	3.3	-0.4	-0.0	-0.1	-1.8	0.3	-1.4
Illnesses of father: High blood pressure	0.7	0.9	2.8	-0.9	-0.2	1.1	0.2	0.7	1.7
Cholesterol lowering medication	0.7	1.1	2.0	-0.9	-1.4	-1.4	0.7	-0.9	-0.5
Pain experienced in last month	0.7	1.1	4.5	0.5	0.7	0.5	-0.7	-2.1	0.7
Pack years of smoking	0.7	1.0	1.7	0.0	1.1	1.0	1.0	1.3	1.0
Bipolar Disorder (2018)	0.6	0.9	1.7	0.7	1.3	1.0	1.0	1.0	-0.3
Reaction Time	0.6	1.1	2.3	-1.1	0.1	1.4	1.5	-0.5	1.1
Verbal and Numeric Reasoning (VNR)	0.6	1.3	3.6	0.8	-0.2	1.9	0.3	-1.8	0.4
Prostate Cancer	0.6	0.9	3.0	0.8	-0.3	1.7	-0.5	0.2	-1.1
Crohns Disease (2012)	0.6	0.9	3.4	-1.0	-1.8	-0.1	-1.0	-0.4	0.0
Neuroticism (2016)	0.6	0.9	1.6	-0.1	-1.0	-1.3	-0.4	1.2	-1.0
Respiratory disease	0.6	1.3	3.6	1.6	0.3	-1.9	-0.0	0.5	-1.0
Lung FVC	0.6	3.1	7.4	-2.6	-2.7	0.4	-1.8	-0.4	-0.8
Sensitivity / hurt feelings	0.6	1.0	4.8	-0.6	0.1	0.3	0.3	2.2	-0.9
Frequency of depressed mood in last 2 weeks	0.6	0.9	3.9	-0.8	-0.5	0.1	0.2	2.0	-0.6
Medication: Metformin	0.6	0.8	2.9	-0.3	-1.7	-0.9	0.4	-0.6	-0.6
Pack years adult smoking proportion	0.6	0.9	1.2	-0.2	0.9	1.0	1.0	1.1	1.0
Leg fat-free mass (left)	0.6	3.4	10.0	-3.2	-2.9	-0.5	0.2	-1.1	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.2	-1.0	-0.1	-1.2	0.0	1.5	-0.2
Supplements: Glucosamine	0.6	0.8	3.1	-0.7	0.2	0.3	-0.4	-1.8	0.8
High blood pressure (mother)	0.6	0.9	3.5	-1.9	-1.2	0.0	-0.0	0.5	0.2
Alcohol usually taken with meals	0.6	0.9	1.8	0.9	1.0	-0.1	-0.7	1.3	-1.2
Arm fat mass (right)	0.6	2.6	8.3	-2.9	-2.2	0.2	0.2	-1.5	0.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.0	-0.5	-1.2	1.4	0.1	-1.3	1.4
High blood pressure (siblings)	0.6	0.9	3.1	1.0	-0.4	-0.8	-0.6	1.7	-0.4
Medication: Allopurinol	0.6	0.8	3.8	0.3	0.3	2.0	-0.0	0.1	0.8
Heart disease (mother)	0.6	0.7	2.1	1.4	0.4	-1.1	0.5	0.5	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.7	-0.5	-0.6	-0.4	1.3	0.7	1.3
Leg fat mass (right)	0.6	2.5	6.8	-2.6	-1.8	-0.7	0.8	-2.0	0.3
Pulse rate, automated reading	0.6	1.9	7.7	2.8	1.0	0.3	-0.6	1.3	0.7
Supplements: Vitamin C	0.6	0.7	2.5	-0.5	0.2	0.6	0.8	-1.6	0.6
Leg fat-free mass (right)	0.6	3.2	9.7	-3.1	-2.8	-0.4	0.3	-1.0	0.5
Leg predicted mass (right)	0.6	3.5	10.4	-3.2	-2.9	-0.5	0.4	-1.1	0.6
Arm fat mass (left)	0.6	2.4	7.6	-2.8	-1.8	0.1	0.5	-1.7	0.3
Leg fat mass (left)	0.6	2.5	7.4	-2.7	-2.0	-0.7	0.6	-1.8	0.3
Depressed Affect (Nagel 2018)	0.5	1.0	2.2	-1.5	-1.2	-0.1	1.2	1.1	0.1
Breast Cancer	0.5	1.2	5.6	-2.4	0.8	0.8	-0.1	-0.5	0.2
Mean Putamen Volume	0.5	0.6	1.4	0.8	0.4	-0.4	0.7	1.2	0.8
Schizophrenia (2014)	0.5	1.1	2.9	0.9	1.7	1.7	0.6	0.2	0.3
Number of treatments/medications taken	0.5	0.8	1.6	-0.8	-1.0	-1.0	1.3	-0.4	0.9
Average weekly spirits intake	0.5	0.6	1.7	0.2	-0.8	0.4	1.1	-1.3	0.2
Diabetes (father)	0.5	0.6	1.1	1.1	0.8	-1.0	0.6	-0.4	-0.6
Hand grip strength (right)	0.5	1.3	2.7	-0.9	-1.2	1.6	-1.5	0.3	0.8
Average weekly fortified wine intake	0.5	0.6	1.8	-0.2	0.1	1.0	-0.3	-0.8	1.4
Fed-up feelings	0.5	0.9	1.9	-0.9	-0.7	1.0	0.5	1.4	0.8
Qualifications: CSEs or equivalent	0.5	0.7	1.6	-0.6	-1.3	0.8	-0.8	0.5	-0.7
Chronic bronchitis/emphysema (father)	0.5	0.6	3.2	0.4	0.5	1.8	-0.1	-0.2	-0.4
Impedance of leg (left)	0.5	2.2	9.1	3.0	1.8	0.3	-0.1	0.7	-0.6
Waist circumference	0.5	2.0	5.2	-2.3	-1.4	-0.8	1.3	-1.2	0.9
Medication: Ramipril	0.5	0.7	1.3	-0.7	-0.3	-0.4	0.9	-1.1	1.2
Number of live births	0.5	0.7	1.4	-0.7	-0.9	1.1	0.1	-0.7	1.2
Qualifications: A levels/AS levels or equivalent	0.5	1.1	4.0	-0.7	-2.0	1.1	-0.0	0.4	-0.6
Mouth/teeth dental problems: Dentures	0.5	0.9	2.7	0.2	0.7	-0.9	0.8	-1.6	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.2	-0.1	-0.9	-1.0	0.5	-1.1	-0.9
Tense / ‘highly strung’	0.5	0.8	3.1	0.3	0.2	0.5	0.2	1.7	-1.2
Hair/balding pattern: Pattern 4	0.5	1.1	3.8	-0.2	-0.3	-1.9	-1.0	1.3	-0.4
Neck or shoulder pain in last month	0.5	0.7	1.5	1.2	-0.3	-1.2	0.2	1.0	0.6
Whole body fat mass	0.5	2.0	5.5	-2.3	-1.5	-0.4	0.8	-1.9	0.5
Suffer from ‘nerves’	0.5	0.8	2.8	0.2	0.7	0.7	-0.7	1.7	-0.7
Family relationship satisfaction	0.5	0.6	2.7	0.0	0.5	0.3	0.3	-0.5	1.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.5	1.3	1.1	0.5	1.0	0.1	0.7	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	0.3	-0.6	-0.5	-1.1	1.1	0.3
Mood swings	0.5	0.9	2.2	-0.0	-0.8	-0.5	1.5	1.4	-0.3
Mineral and other dietary supplements	0.5	0.7	2.8	0.5	0.5	0.7	0.2	1.7	-0.3
Wears glasses or contact lenses	0.5	0.5	2.2	-0.6	0.7	0.2	1.5	0.4	-0.2
Eye problems/disorders: Glaucoma	0.5	0.5	2.2	0.3	0.0	-0.3	-0.8	1.5	0.5
High cholesterol (Self-reported)	0.5	1.0	1.9	-0.8	-1.4	-0.9	1.2	-0.2	-0.9
Medication: Bendroflumethiazide	0.5	0.8	2.2	0.6	0.8	-0.3	-0.3	1.3	-1.5
Ever depressed for a whole week	0.5	0.7	1.1	-0.5	-0.3	-1.0	-0.8	0.9	1.1
Myopia	0.5	0.8	4.0	-0.6	0.4	0.3	2.0	-0.4	0.1
Heart disease (siblings)	0.5	0.6	1.8	0.3	0.5	1.1	-0.5	1.3	0.3
Bipolar Disorder or Schizophrenia	0.4	1.1	2.3	0.6	1.5	1.3	0.7	1.2	-0.0
Worry (Nagel 2018)	0.4	0.9	3.8	0.6	0.5	0.4	-0.9	1.9	-0.4
Lupus	0.4	0.6	1.3	1.2	1.0	0.9	-0.3	0.5	-0.1
Blood Red Count	0.4	4.0	13.7	1.1	0.2	2.1	-1.9	1.0	-3.7
Smoking Status	0.4	0.9	3.5	1.9	0.7	-0.2	0.9	0.5	0.3
Hypothyroidism (self reported)	0.4	0.9	1.6	0.2	-1.2	1.3	-0.8	-0.2	1.2
Neuroticism	0.4	1.1	4.2	0.0	0.0	0.6	0.1	2.0	-1.4
Impedance of leg (right)	0.4	2.2	9.7	3.1	1.5	0.4	-0.1	0.5	-0.8
Multivitamins +/- minerals	0.4	0.5	1.5	0.2	-0.8	0.1	0.1	-1.2	-0.8
Medication: Atenolol	0.4	0.5	1.0	0.6	0.6	1.0	0.2	-0.1	-1.0
Trunk fat mass	0.4	1.8	4.5	-2.1	-1.5	-0.3	0.9	-1.7	0.2
Nervous feelings	0.4	0.7	2.2	-0.4	-1.0	1.5	-0.1	-0.8	0.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	-0.7	-0.1	-1.2	0.7	0.6	0.1
Financial difficulties in last 2 years	0.4	0.5	2.3	0.5	0.3	0.3	-0.3	1.5	-0.5
Medication: Simvastatin	0.4	0.6	2.4	0.9	0.2	-0.4	1.5	-0.4	-0.5
Illnesses of siblings	0.4	0.6	2.6	-1.6	0.3	-0.1	0.2	-0.7	0.6
Neuroticism score	0.4	0.9	3.4	-0.7	-0.7	0.8	0.0	1.8	-0.8
Arm fat percentage (right)	0.4	1.7	5.0	-2.2	-1.5	-0.1	0.4	-1.7	-0.3
Worrier / anxious feelings	0.4	0.7	2.0	0.4	-0.1	-0.3	-1.3	1.4	-0.6
Falls in the last year	0.4	0.6	1.8	0.3	-0.5	-1.4	1.0	-0.3	0.6
Lung cancer (father)	0.4	0.4	1.2	0.6	0.6	0.6	0.1	-1.1	-0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.8	0.2	-0.1	-0.1	-1.3	0.8	-0.5
Blood clot in the leg (DVT)	0.4	0.5	1.7	1.0	0.4	1.3	-0.2	-0.6	-0.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.9	0.2	-0.9	-0.8	0.9	-1.0	-0.1
Leg fat percentage (right)	0.4	1.3	4.8	-1.4	-0.6	-0.5	0.7	-2.2	-0.2
Exposure to tobacco smoke outside home	0.4	0.6	1.0	-0.2	-0.3	1.0	-0.5	1.0	-1.0
Wheeze or whistling in the chest in last year	0.4	0.7	1.9	0.7	-0.2	-0.8	-0.7	0.8	-1.4
Age at first live birth	0.4	0.7	1.6	0.9	1.3	0.1	-0.7	1.0	-0.5
Eye problems/disorders: None of the above	0.4	0.5	1.0	-0.4	-1.0	0.8	0.3	-0.6	-0.9
Had major operations	0.4	0.5	1.3	-0.3	0.7	1.1	-0.8	0.5	-0.7
Age at last live birth	0.4	0.6	1.7	0.4	1.1	1.3	-0.3	0.5	0.1
Leg pain on walking	0.4	0.5	2.7	-0.1	-0.6	-0.0	1.6	-0.0	0.1
Illnesses of siblings: Diabetes	0.4	0.4	1.1	0.8	-1.1	-0.3	-0.4	0.8	-0.2
Arm fat percentage (left)	0.4	1.8	4.6	-2.1	-1.3	-0.3	0.6	-1.9	-0.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.3	-0.6	-0.2	1.1	0.5	-0.5	-0.7
Number of self-reported non-cancer illnesses	0.4	0.7	2.6	0.2	0.1	0.0	1.6	0.2	1.1
Financial situation satisfaction	0.4	0.5	1.6	-0.6	-1.2	0.7	-0.5	-0.8	0.2
Medication: Blood pressure	0.4	0.8	3.0	-0.1	0.5	1.1	1.7	-0.6	-0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.4	0.8	0.0	-0.3	-0.1	1.2	-0.9
Leg fat percentage (left)	0.4	1.3	4.0	-1.6	-0.7	-0.5	0.7	-2.0	-0.1
Risk taking	0.4	0.5	1.8	0.7	1.4	-0.3	0.7	-0.5	0.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	0.4	1.0	0.6	0.8	-0.2	0.9
Neuroticism (Nagel 2018)	0.3	0.8	1.9	-1.4	-1.1	0.2	0.8	0.8	-0.4
Schizophrenia (2018)	0.3	0.6	1.4	0.6	1.2	1.1	-0.1	0.8	0.2
Ulcerative Colitis (UC)	0.3	0.5	1.2	0.1	-0.7	-0.1	1.1	-1.0	0.6
Body Mass Index (BMI) (2010)	0.3	0.3	1.0	0.2	0.4	-0.2	1.0	-0.9	0.3
LDL Cholesterol	0.3	0.5	1.4	0.3	-0.5	-0.9	1.2	-0.6	-0.1
Blood Platelet Count	0.3	4.0	13.2	3.6	2.4	-0.6	0.0	2.1	-0.6
Systolic Blood Pressure	0.3	1.6	4.9	2.0	0.7	2.2	-0.5	0.4	-0.3
Relative age of first facial hair	0.3	0.6	1.5	0.5	0.8	1.2	0.8	-0.2	0.8
Supplements: Zinc	0.3	0.3	1.1	1.0	0.4	-0.5	0.5	-0.3	0.2
Diabetes (mother)	0.3	0.4	1.0	-1.0	-0.5	0.6	-0.2	0.4	0.6
Trunk fat percentage	0.3	1.1	2.5	-1.4	-0.8	-0.3	1.0	-1.6	-0.0
Current tobacco smoking	0.3	0.4	1.2	0.4	0.0	0.7	-0.3	1.1	0.7
High blood pressure	0.3	0.8	1.5	1.1	1.2	0.3	1.1	-0.1	0.7
Number of incorrect matches in round	0.3	0.5	1.4	0.6	1.2	-0.5	-0.0	0.0	0.9
Hair/balding pattern: Pattern 3	0.3	0.4	1.4	0.4	-0.2	1.2	0.5	-0.1	-0.6
Loud music exposure frequency	0.3	0.3	1.2	0.4	0.6	-0.2	-0.1	1.1	-0.4
Headache pain in last month	0.3	0.5	1.4	-0.8	-0.4	0.5	-0.7	1.2	-0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.0	0.9	1.0	0.7	-0.6	0.5	-0.4
Body fat percentage	0.3	1.3	3.6	-1.5	-0.7	-0.5	1.0	-1.9	0.1
Emphysema/chronic bronchitis	0.3	0.3	1.1	-0.0	-0.5	-0.5	1.0	-0.2	0.3
Comparative height size at age 10	0.3	1.4	4.3	0.2	-1.1	-2.1	0.8	1.4	-0.2
Number of full sisters	0.3	0.4	0.7	-0.7	-0.8	-0.7	-0.8	-0.5	0.1
Hypertension (Self-reported)	0.3	0.9	1.9	0.9	1.3	-0.1	1.4	-0.3	0.9
Average weekly red wine intake	0.3	0.4	1.9	-0.2	0.2	-0.5	0.5	-1.4	0.0
Diabetes diagnosed by doctor	0.3	0.5	0.9	0.1	-0.8	-0.8	0.8	-0.9	0.2
Medication for cholesterol	0.3	0.5	1.6	0.8	0.2	-0.4	-1.2	0.6	-0.5
Breast cancer (self-reported)	0.3	0.4	1.0	1.0	0.1	-0.4	-0.4	-0.3	0.9
Osteoarthritis (self-reported)	0.3	0.4	1.8	0.3	-0.1	-0.5	-1.4	-0.1	0.5
Ever taken oral contraceptive pill	0.3	0.3	1.2	0.1	0.0	-0.3	1.1	0.5	0.4
Hearing aid user	0.3	0.4	1.1	0.4	0.5	-0.2	0.6	1.1	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.8	1.9	-0.2	-0.4	1.1	1.4	-1.0	0.3
Crohns Disease (2017)	0.2	0.4	1.7	0.4	-0.3	-0.2	-0.6	1.3	0.3
Fasting Glucose	0.2	0.2	0.6	0.8	0.1	0.8	-0.0	-0.0	-0.4
Rheumatoid Arthritis	0.2	0.3	1.3	-0.5	0.1	1.1	-0.3	0.5	0.0
Heel T-Score	0.2	1.6	6.7	1.1	1.2	0.2	0.1	-2.6	0.6
Allergy or Eczema	0.2	0.6	2.2	0.5	-1.5	0.9	0.0	-0.6	0.3
Cardiovascular Disease	0.2	0.6	1.6	0.5	0.4	-1.1	1.3	0.2	-0.6
Hair Pigment	0.2	6.3	30.2	0.6	-1.8	-2.0	0.5	-0.2	-5.5
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	0.5	-0.4	-0.5	-0.8	-0.2	-0.4
Systolic blood pressure, automated reading	0.2	0.5	1.6	1.3	0.1	0.8	-0.6	0.2	-0.6
Medication for hormone replacement therapy	0.2	0.3	1.0	-1.0	0.1	0.6	0.4	0.1	-0.2
Severe depression (siblings)	0.2	0.3	0.8	-0.2	-0.5	-0.4	0.9	-0.5	-0.2
Maternal smoking around birth	0.2	0.4	0.9	0.6	-0.9	-0.7	-0.6	-0.1	0.1
Sitting height	0.2	1.3	2.9	-1.1	-1.7	1.6	-0.3	-0.0	-1.0
Hearing difficulty/problems with background noise	0.2	0.4	1.3	-0.1	-0.3	-0.1	1.1	-0.3	0.8
Qualifications: None of the above	0.2	0.4	0.7	-0.6	-0.8	0.6	-0.9	-0.6	-0.4
Mouth/teeth dental problems	0.2	0.3	1.2	-0.2	-0.2	0.2	0.5	1.1	-0.3
Allergy	0.2	0.6	2.2	-0.6	1.5	-0.6	-0.3	0.6	0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	-0.2	-0.3	-0.1	0.8	0.7	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.4	-0.2	-0.3	0.1	-0.3	1.2	-0.4
Asthma	0.2	0.5	1.9	1.0	0.1	-1.4	-0.2	0.1	-0.2
Medication: Cholesterol lowering	0.2	0.3	1.0	0.1	-0.6	0.3	1.0	0.1	0.3
Prospective memory result	0.2	0.3	0.6	0.8	0.5	0.1	0.6	-0.5	0.5
Medication: Paracetamol	0.2	0.3	1.1	0.6	0.2	0.3	-0.0	0.5	1.1
Gout (self-reported)	0.2	0.3	0.9	-0.4	-0.3	0.9	-0.6	-0.4	0.6
Qualifications: College or University degree	0.2	0.6	1.8	-1.3	-0.6	-0.0	0.1	-0.7	1.0
Alcohol intake frequency.	0.2	0.4	2.2	-0.6	-0.1	1.5	-0.2	-0.2	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.9	-0.5	-1.4	0.2	-0.1	0.3	-0.3
Friendships satisfaction	0.2	0.3	0.7	-0.8	0.5	-0.4	0.4	0.7	0.3
Asthma (self-reported)	0.2	0.4	1.3	0.9	-0.0	-1.1	-0.4	-0.1	-0.3
Smoking status: Current	0.2	0.4	0.9	0.3	0.1	0.9	-0.3	1.0	0.7
Medication: Paracetamol	0.2	0.3	0.7	0.9	0.1	-0.1	-0.4	0.5	0.8
Average weekly beer plus cider intake	0.2	0.3	0.5	0.2	-0.7	-0.4	0.4	-0.7	0.6
Vascular/heart problems diagnosed by doctor	0.2	0.7	2.2	-0.5	-0.7	0.1	-1.5	0.5	-0.9
Irritable Bowel Disease (IBD)	0.1	0.2	0.7	0.4	-0.5	0.0	0.6	-0.1	0.8
Bipolar Disorder (2011)	0.1	0.1	0.7	0.8	0.1	0.2	0.0	0.0	0.0
Triglycerides	0.1	0.2	0.9	0.4	0.1	0.1	1.0	0.1	-0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.5	0.2	0.2	0.1	-0.5	-0.7	0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	0.6	-0.1	-0.7	0.2	-0.1	-0.3
Lung FEV1/FVC ratio	0.1	0.5	2.0	0.5	0.6	1.4	-0.0	-0.2	0.8
Tanning	0.1	0.9	2.9	0.4	1.4	0.4	0.1	0.4	1.7
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.3	0.3	-1.1	0.7	0.1	-0.3	-0.1
Diabetes (self-reported)	0.1	0.1	0.4	0.3	-0.7	-0.3	-0.1	-0.5	-0.1
Illnesses of mother	0.1	0.2	0.4	0.1	-0.5	0.6	0.3	-0.5	-0.2
Glaucoma (self-reported)	0.1	0.1	0.3	0.5	0.1	0.0	-0.1	0.3	0.6
Medication for pain relief, constipation, heartburn	0.1	0.2	0.7	-0.8	-0.2	0.5	-0.1	-0.1	0.1
Medication: Blood pressure	0.1	0.1	0.4	-0.3	-0.2	-0.2	0.7	0.2	0.1
Illnesses of father: Heart disease	0.1	0.2	0.4	0.1	0.6	0.5	0.4	0.7	0.0
Diastolic blood pressure, automated reading	0.1	0.4	1.5	0.6	-1.2	-0.8	-0.2	-0.1	-0.3
Height	0.0	0.5	1.0	1.0	-0.1	-1.0	0.8	-0.2	0.3
Hair/balding pattern: Pattern 2	0.0	0.1	0.2	0.2	0.1	-0.2	-0.1	-0.4	-0.0
Standing height	0.0	0.5	2.3	0.1	-1.5	0.1	0.6	-0.2	0.2

Hub : Genes

GCNT2

Models

Trait associations