TWAS hub - GDPD3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.1512	0.0714	8.4e-03	0.027	NA	0.030	NA	0.118	3.7e-02	NA	2.9e-02	NA	5.3e-05
2	GTEx	Artery Tibial	0.0810	0.0420	2.7e-03	0.050	NA	0.047	NA	0.045	8.9e-05	NA	1.5e-04	NA	1.8e-04
3	GTEx	Colon Transverse	0.1780	0.0720	9.2e-03	0.054	NA	0.074	NA	0.030	1.4e-03	NA	2.1e-04	NA	1.4e-02
4	GTEx	Muscle Skeletal	0.1194	0.0538	3.2e-03	0.003	NA	0.011	NA	0.007	1.5e-01	NA	2.4e-02	NA	6.5e-02
5	GTEx	Nerve Tibial	0.2059	0.0563	5.0e-06	0.007	NA	0.046	NA	0.026	9.3e-02	NA	3.5e-04	NA	6.1e-03
6	GTEx	Thyroid	0.2500	0.0750	8.1e-05	0.008	NA	0.098	NA	0.027	6.9e-02	NA	6.4e-08	NA	3.5e-03
7	GTEx	Whole Blood	0.2340	0.0510	2.7e-08	0.005	NA	0.097	NA	0.034	9.6e-02	NA	3.2e-09	NA	3.9e-04
8	METSIM	Adipose	0.4017	0.0609	0.0e+00	0.124	0.143	0.144	0.150	0.151	4.6e-18	9.8e-21	5.6e-21	8.4e-22	5.9e-22
9	ROSMAP	Brain Pre-frontal Cortex	0.0719	0.0281	3.4e-05	0.028	0.028	0.025	0.024	0.024	1.4e-04	1.6e-04	2.9e-04	3.5e-04	3.7e-04
10	YFS	Blood	0.4901	0.0318	0.0e+00	0.155	0.284	0.299	0.268	0.257	2.4e-48	1.1e-93	1.1e-99	7.3e-88	1.8e-83
11	TCGA	Brain Lower Grade Glioma	0.2295	0.1040	1.2e-09	0.037	0.084	0.103	NA	0.073	3.9e-05	8.6e-10	9.4e-12	NA	9.9e-09
12	TCGA	Thyroid Carcinoma	0.1010	0.0540	1.7e-04	0.049	0.046	0.044	NA	0.048	1.4e-05	2.7e-05	4.2e-05	NA	1.9e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Blood Red Count	11.8	113.7	240.2	-10.7	14.4	1.8	8.3	11.6	3.3	8.4	6.9	15.5	15.2	13.5	7.4
Number of incorrect matches in round	8.6	14.3	34.5	-3.4	5.9	2.1	1.8	4.2	1.8	4.7	3.9	5.2	4.1	3.9	0.8
Impedance of leg (right)	7.1	34.3	81.5	-8.2	8.0	0.9	1.4	5.5	3.1	7.5	4.1	9.0	6.3	6.5	1.3
Leg fat-free mass (right)	6.7	35.6	79.6	8.3	-8.9	-1.1	-1.5	-5.9	-2.5	-8.5	-4.6	-8.4	-6.1	-5.4	2.1
Leg predicted mass (right)	6.7	35.6	79.6	8.2	-8.9	-1.1	-1.4	-5.9	-2.6	-8.6	-4.6	-8.4	-6.1	-5.4	2.0
Impedance of leg (left)	6.6	32.3	73.4	-7.5	7.8	1.3	1.4	5.6	3.2	7.4	4.1	8.6	6.2	6.5	1.1
Impedance of whole body	6.4	32.7	79.2	-7.5	7.9	1.0	2.0	5.2	3.5	7.8	4.3	8.9	5.8	6.1	1.0
Leg fat-free mass (left)	6.3	33.4	73.6	8.1	-8.6	-1.0	-1.3	-5.8	-2.3	-8.3	-4.3	-8.1	-5.9	-5.3	2.1
Leg predicted mass (left)	6.3	33.3	73.1	8.1	-8.6	-1.0	-1.2	-5.8	-2.3	-8.3	-4.2	-8.1	-5.8	-5.3	2.2
Basal metabolic rate	6.3	35.0	79.2	8.1	-8.9	-1.0	-1.3	-5.8	-2.3	-8.7	-4.6	-8.2	-6.0	-5.1	2.6
Whole body water mass	6.2	35.2	82.6	7.6	-9.1	-1.5	-1.7	-5.8	-2.9	-8.9	-5.0	-8.1	-5.9	-4.9	2.7
Whole body fat-free mass	6.1	34.7	82.3	7.4	-9.1	-1.5	-1.6	-5.8	-2.9	-8.9	-5.0	-7.9	-5.8	-4.8	2.8
Weight	5.7	27.8	76.9	8.8	-7.2	0.4	0.9	-5.0	-0.5	-7.4	-2.8	-7.4	-5.4	-5.2	1.8
Trunk fat-free mass	5.6	32.1	81.2	6.2	-9.0	-2.0	-1.8	-5.7	-3.4	-8.7	-5.4	-7.2	-5.5	-4.2	3.0
Trunk predicted mass	5.6	32.0	81.5	6.2	-9.0	-2.0	-1.8	-5.7	-3.4	-8.7	-5.4	-7.2	-5.5	-4.2	3.1
Arm fat-free mass (right)	5.5	28.1	67.2	7.0	-7.9	-1.1	-1.4	-5.0	-2.2	-8.2	-4.2	-7.5	-5.2	-4.4	2.3
Arm predicted mass (left)	5.5	27.8	65.6	7.4	-7.9	-0.5	-1.1	-5.3	-2.0	-8.1	-3.6	-7.1	-5.2	-4.4	2.8
Body mass index (BMI)	5.4	23.2	79.6	8.9	-5.4	1.3	1.2	-4.1	0.3	-5.7	-1.4	-7.7	-4.9	-5.6	-0.7
Arm fat mass (left)	5.4	22.3	73.3	8.6	-5.8	0.8	1.1	-4.6	0.4	-5.6	-1.5	-7.3	-4.9	-5.2	0.3
Arm fat-free mass (left)	5.4	27.5	63.2	7.5	-7.8	-0.5	-1.1	-5.0	-1.8	-8.0	-3.8	-7.2	-5.2	-4.4	2.7
Arm predicted mass (right)	5.3	27.2	65.0	6.9	-7.8	-1.0	-1.3	-4.9	-2.0	-8.1	-4.3	-7.2	-5.1	-4.3	2.5
Arm fat mass (right)	5.2	21.4	71.7	8.5	-5.6	0.9	1.3	-4.4	0.4	-5.7	-1.4	-7.1	-4.6	-5.0	0.5
Hip circumference	5.1	22.1	72.2	8.5	-6.0	1.6	0.9	-4.8	-0.2	-5.6	-1.4	-6.7	-5.0	-5.2	0.7
Waist circumference	4.9	18.0	58.7	7.7	-5.2	0.4	3.0	-4.1	1.3	-5.8	-1.0	-5.7	-3.9	-4.3	1.3
BMI	4.4	25.4	68.1	8.2	-5.9	1.1	2.3	-4.4	-0.1	-6.1	-2.3	-7.8	-6.4	-5.7	-0.4
Medication: Ventolin 100micrograms inhaler	4.4	5.7	13.3	1.5	-2.5	-1.0	-1.7	-1.0	-1.0	-0.7	-2.5	-3.6	-3.4	-3.5	-3.2
Impedance of arm (right)	4.3	20.3	55.4	-5.7	5.9	0.8	2.0	3.8	2.4	6.5	3.4	7.4	4.3	4.7	1.1
Ever had hysterectomy (womb removed)	4.0	4.5	9.8	-0.2	3.0	1.4	1.6	1.4	1.8	2.5	3.1	2.9	2.8	1.8	0.1
Impedance of arm (left)	4.0	18.5	47.6	-5.8	6.0	0.5	1.5	3.4	2.3	6.3	3.2	6.9	4.0	4.4	0.4
Ulcerative Colitis	3.9	5.6	18.0	2.8	0.0	-0.4	-1.4	-1.0	-3.3	-3.3	-2.2	-4.2	-2.1	-1.5	-2.4
Relative age voice broke	3.9	6.0	16.9	-0.8	3.0	1.8	0.6	4.1	2.5	3.8	2.1	1.9	2.8	1.8	1.4
Alcohol usually taken with meals	3.9	6.2	13.4	-1.5	-3.5	-3.2	-1.3	-3.2	-1.8	-2.9	-3.7	-1.7	-2.5	-1.8	-1.0
Number of children fathered	3.8	4.3	9.6	3.1	-2.4	-0.3	-1.0	-1.6	-2.4	-2.7	-1.3	-3.1	-2.4	-1.5	-0.5
Leg fat mass (left)	3.8	14.8	56.1	7.5	-4.4	1.4	1.4	-3.4	1.0	-4.7	-0.5	-5.7	-3.7	-4.2	0.5
Whole body fat mass	3.7	15.4	58.5	7.7	-4.3	1.3	2.1	-3.6	0.9	-5.0	-0.6	-5.7	-3.8	-4.1	0.9
High cholesterol (Self-reported)	3.6	6.3	15.3	-0.6	3.4	1.2	3.9	3.0	3.6	1.0	2.4	2.8	2.3	1.9	1.1
Leg fat mass (right)	3.5	13.4	49.7	7.0	-4.2	1.3	1.4	-3.2	1.0	-4.6	-0.6	-5.4	-3.5	-3.9	0.7
Medication: Simvastatin	3.3	4.9	11.7	0.7	3.4	2.1	3.2	2.6	1.7	1.3	3.0	1.5	2.2	1.7	1.0
Wheeze or whistling in the chest in last year	3.2	5.7	17.7	4.2	-2.6	-0.2	-0.7	-2.8	-1.7	-2.1	-1.5	-3.8	-2.7	-1.7	-1.0
Arm fat percentage (right)	3.1	12.0	51.6	7.2	-3.4	1.6	2.5	-3.0	1.4	-3.1	0.1	-5.0	-3.3	-3.9	0.1
Arm fat percentage (left)	3.1	12.5	51.6	7.2	-3.4	1.4	2.3	-3.1	1.5	-3.2	-0.2	-5.3	-3.5	-4.1	-0.1
Trunk fat mass	3.0	12.9	48.4	7.0	-3.9	1.1	2.0	-3.3	1.1	-4.6	-0.6	-5.0	-3.6	-3.6	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.0	3.5	10.4	1.1	-1.5	-1.7	-0.5	-1.2	-0.4	-1.8	-2.6	-3.2	-1.9	-1.5	-2.7
Comparative height size at age 10	2.8	15.5	48.4	1.5	-6.2	-4.2	-0.6	-4.6	-2.5	-7.0	-4.7	-3.8	-2.5	-1.6	2.5
Asthma (self-reported)	2.8	5.7	14.4	3.2	-2.9	-0.4	-1.6	-1.4	-0.8	-0.9	-1.7	-3.4	-3.8	-3.1	-2.2
Risk taking	2.6	3.7	8.0	-0.8	-2.8	-2.1	-2.5	-2.2	-2.8	-1.5	-2.6	-1.4	-1.3	-0.5	-0.0
Time employed in main current job	2.5	2.9	5.5	-0.7	2.1	0.7	1.7	1.7	2.1	1.4	1.9	2.4	2.2	1.7	0.8
Comparative body size at age 10	2.5	7.0	24.1	4.9	-1.5	0.3	2.5	-1.3	2.4	-2.2	-0.9	-4.0	-2.2	-3.6	-1.8
Cholesterol lowering medication	2.5	3.7	11.8	-0.1	2.6	1.5	3.4	2.4	2.4	1.0	1.8	1.1	1.7	1.5	1.1
Prostate Cancer	2.4	3.4	8.0	-0.3	1.8	0.6	2.1	2.0	1.9	2.8	1.2	1.8	1.9	2.2	1.9
Respiratory disease	2.4	5.4	15.1	2.1	-2.9	-0.4	-1.0	-1.6	-0.1	-1.1	-2.1	-2.9	-3.9	-3.1	-3.0
Qualifications: NVQ or HND or HNC or equivalent	2.4	2.9	14.6	3.8	-0.4	1.2	0.2	-1.0	-0.0	-2.5	0.2	-2.5	-1.6	-1.3	0.3
Commuting to job workplace: Cycle	2.4	2.9	8.5	-0.1	0.3	1.1	2.2	0.5	-0.3	2.6	1.7	2.9	1.7	1.3	2.3
Diabetes (father)	2.3	2.8	8.9	1.5	-3.0	-0.1	-0.9	-2.8	-1.4	-2.1	-1.1	-1.6	-1.6	-1.0	0.2
Multivitamins +/- minerals	2.3	3.0	20.1	1.2	0.7	2.2	-0.5	0.5	0.7	1.0	1.2	1.0	0.8	1.9	4.5
Asthma	2.3	4.6	11.3	3.0	-2.7	-0.2	-1.8	-1.2	-0.5	-0.6	-1.5	-3.0	-3.4	-2.8	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.3	2.9	8.6	-2.5	2.9	-0.8	1.3	1.7	0.6	1.2	0.8	2.6	1.6	1.8	0.5
Shortness of breath walking on level ground	2.3	2.7	5.5	0.9	-1.0	-1.9	1.2	-1.7	-2.3	-1.5	-0.8	-1.8	-1.7	-1.9	-2.3
Long-standing illness, disability or infirmity	2.3	3.5	7.7	1.3	-2.0	-1.3	-1.0	-2.4	-1.2	-1.6	-1.6	-2.8	-2.0	-2.2	-2.2
Primary Biliary Cirrhosis	2.2	3.2	17.8	4.2	-1.1	1.4	-0.3	-0.0	0.2	0.3	-0.3	-3.0	-1.9	-1.3	-1.8
High blood pressure (siblings)	2.2	3.2	6.8	1.3	2.1	1.3	2.6	1.7	2.1	1.1	2.4	1.1	1.7	1.8	1.3
Family relationship satisfaction	2.2	2.7	9.5	-3.1	-1.5	-1.5	-0.8	-0.3	-2.0	0.1	-2.5	1.4	0.4	1.3	2.0
Eye problems/disorders: Cataract	2.2	2.5	6.2	-2.3	2.3	0.8	1.2	1.0	0.8	0.7	1.4	2.5	1.5	1.9	0.9
Age when periods started (menarche)	2.1	5.1	13.8	-3.6	3.1	2.1	-1.6	3.7	1.2	1.6	-0.6	3.2	0.3	1.5	-0.5
Mouth/teeth dental problems	2.1	3.2	18.1	-4.2	-1.0	-2.0	-1.2	0.5	-0.9	0.1	-3.2	1.4	-0.4	0.3	-0.4
Tense / ‘highly strung’	2.1	3.5	10.1	-1.2	3.2	-0.3	1.6	1.7	-0.6	2.4	2.3	2.6	2.2	1.1	-0.8
Forced vital capacity (FVC), Best measure	2.1	7.5	22.0	-1.7	-4.7	-3.9	-3.2	-1.8	-2.6	-2.0	-4.1	-1.0	-2.3	-0.9	1.3
Ulcerative Colitis (UC)	2.0	3.7	14.7	2.9	-0.6	-0.5	0.1	-0.3	-1.2	-2.9	-1.0	-3.8	-0.3	-1.4	-2.8
Hair/balding pattern: Pattern 3	2.0	3.0	8.7	-0.5	1.8	1.9	1.1	1.9	0.7	2.9	2.1	2.3	1.8	1.2	0.7
Number of live births	2.0	2.8	11.1	0.4	3.0	1.0	0.9	0.5	0.6	1.6	3.3	0.9	2.4	1.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	11.9	-0.4	-2.2	-1.3	-3.5	-2.3	-0.1	0.1	-0.8	-1.2	-1.0	-0.8	-0.3
Body fat percentage	2.0	7.7	36.8	6.1	-1.4	2.2	3.1	-1.9	2.4	-2.3	1.2	-3.4	-2.1	-2.7	0.4
Medication: Bendroflumethiazide	2.0	3.0	13.0	3.6	-0.5	1.8	2.1	0.9	0.7	-1.5	-1.8	-1.8	-1.4	-0.5	1.5
Diastolic blood pressure, automated reading	2.0	6.0	19.6	1.1	0.7	2.9	2.2	2.4	4.4	2.7	1.3	1.6	2.0	1.4	3.8
Blood Eosinophil Count	1.9	14.7	45.2	-6.7	5.3	-5.0	3.1	2.1	-3.0	-0.5	1.1	3.7	4.8	3.6	-2.1
Maternal smoking around birth	1.9	2.8	11.8	3.4	0.7	2.4	-2.2	0.6	1.5	-0.2	0.6	-2.5	-0.5	0.1	-0.5
Forced vital capacity (FVC)	1.9	7.3	22.8	-0.4	-4.8	-3.3	-2.9	-2.0	-2.2	-2.8	-4.0	-1.7	-2.4	-0.9	1.7
Medication: Cholesterol lowering	1.9	3.0	6.0	-0.2	2.4	1.4	0.9	1.6	1.6	1.4	2.3	2.1	2.5	1.6	1.5
Suffer from ‘nerves’	1.9	3.1	9.9	-0.8	3.1	-1.1	1.6	2.3	0.2	1.6	2.1	1.6	2.5	0.4	-1.1
Supplements: Vitamin C	1.9	2.3	9.4	-3.1	-0.6	-1.1	0.7	-0.2	-1.9	0.3	-1.4	2.3	0.3	1.5	1.8
Leg fat percentage (left)	1.9	6.9	33.4	5.8	-1.3	2.6	2.8	-1.2	2.6	-1.6	1.4	-3.2	-1.7	-2.6	-0.1
Basal cell carcinoma (self-reported)	1.9	2.3	13.2	-3.6	-0.2	-1.7	-1.8	-0.4	-0.6	0.1	-0.9	1.3	1.0	1.7	1.1
Hearing difficulty/problems with background noise	1.8	2.9	6.0	-0.5	1.9	1.6	1.2	0.7	1.5	2.4	2.1	2.4	2.0	1.7	1.0
Gout (self-reported)	1.8	2.4	4.3	-0.5	-1.5	-2.1	-1.6	-1.5	-1.6	-1.8	-1.1	-1.7	-1.0	-1.7	-1.9
Medication: Aspirin	1.8	2.3	8.1	-2.8	1.4	-1.1	1.4	0.9	0.3	0.3	0.5	2.2	2.3	1.5	1.1
Knee pain experienced in last month	1.8	2.8	8.6	2.9	0.8	0.4	1.1	0.6	0.6	0.3	0.7	-2.9	-1.3	-2.1	-2.6
Medication: Aspirin	1.8	2.4	7.1	-2.7	1.2	-1.0	1.6	1.0	0.3	0.6	0.4	2.3	2.4	1.5	1.4
Bipolar Disorder or Schizophrenia	1.7	4.2	15.9	-4.0	0.0	-0.7	0.2	2.1	-0.7	2.5	-0.4	3.7	2.6	1.7	-0.1
Heel T-Score	1.7	13.4	26.9	-3.2	4.6	1.5	0.1	3.8	0.2	4.7	2.4	5.2	5.0	5.2	2.4
Cardiovascular Disease	1.7	5.5	14.6	2.8	1.4	2.9	3.8	3.1	2.9	0.7	0.7	0.4	1.4	1.3	3.2
Trunk fat percentage	1.7	6.8	31.6	5.6	-1.4	1.9	2.8	-1.9	2.3	-2.2	1.1	-3.2	-2.2	-2.5	0.4
Fed-up feelings	1.7	3.1	12.9	2.5	-1.9	-0.8	-1.0	-1.0	0.0	-2.1	-2.0	-3.6	-0.6	-1.6	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	8.2	-0.2	-2.8	-1.5	-2.5	-1.7	-1.2	-2.9	-2.6	-1.8	-1.7	-1.2	0.5
Depressed Affect (Nagel 2018)	1.6	3.5	12.7	3.2	-0.2	-0.5	-0.4	-0.9	-0.4	-2.7	-1.2	-3.6	-1.4	-1.9	-1.8
Systolic blood pressure, automated reading	1.6	4.5	9.6	1.8	1.5	2.6	2.6	1.9	2.6	0.7	2.6	0.9	2.3	1.5	3.1
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	8.1	-0.6	1.8	1.1	-0.7	1.1	0.4	2.8	2.4	2.8	2.0	2.5	2.3
Birth weight of first child	1.6	2.9	7.4	1.5	-2.5	-0.2	-0.6	-1.0	-0.7	-1.3	-2.0	-2.7	-2.3	-2.6	-0.6
Neck or shoulder pain in last month	1.6	2.3	12.6	3.6	-1.4	1.0	-0.0	-0.5	0.8	-1.3	-0.3	-2.1	-1.9	-0.8	1.1
Supplements: Calcium	1.6	1.7	3.3	-0.4	1.5	0.8	1.8	0.3	0.3	1.8	1.4	1.6	1.3	1.5	1.7
Schizophrenia (2018)	1.5	3.2	12.2	-3.5	0.0	-0.9	0.2	2.0	-0.3	1.8	-0.2	3.1	2.5	1.6	-0.0
Schizophrenia (2014)	1.5	3.4	13.7	-3.7	0.0	-1.2	0.8	2.3	-0.7	2.0	-0.7	2.9	1.9	1.4	-0.4
Blood White Count	1.5	11.0	31.7	-5.1	0.9	-5.5	-2.1	-0.7	-5.6	-2.1	0.2	2.4	2.9	4.1	1.8
Systolic Blood Pressure	1.5	7.5	32.0	1.3	0.8	2.3	2.9	2.9	2.8	1.2	1.4	2.1	3.3	2.7	5.7
Lung FEV1/FVC ratio	1.5	7.4	17.9	-2.0	4.2	-0.3	1.8	2.3	-1.6	2.1	2.5	3.6	4.2	3.4	1.6
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	3.6	-1.2	1.8	-0.2	1.7	1.0	0.9	0.6	1.2	1.9	1.6	1.9	0.3
Nervous feelings	1.5	2.9	11.3	-1.5	3.0	-1.7	-0.0	1.0	-1.3	0.7	1.5	0.7	1.5	0.8	-3.4
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	6.4	-0.0	-1.5	-1.2	-1.2	-1.9	-1.4	0.3	-0.6	-1.8	-2.0	-2.3	-2.5
Leg fat percentage (right)	1.5	5.4	25.0	5.0	-0.9	2.4	2.8	-1.1	2.5	-1.4	1.5	-2.6	-1.4	-2.3	0.1
Qualifications: College or University degree	1.5	4.6	24.1	-4.9	-1.0	-3.0	-2.6	-1.3	-2.5	-0.6	-2.0	0.9	-0.2	-0.3	-0.6
Alcohol intake frequency.	1.5	3.5	12.8	3.6	-1.3	0.8	3.5	-0.6	0.7	-1.7	-0.0	-1.0	0.2	0.5	3.2
Medication for cholesterol	1.5	2.2	11.0	-1.0	-1.2	-0.4	-3.3	-1.7	-1.6	-0.5	-1.7	-0.8	-1.2	-0.8	-1.3
Body Mass Index (BMI) (2010)	1.4	2.0	9.3	3.1	-1.3	1.3	-0.5	-1.8	0.1	-0.3	0.5	-1.5	-1.4	-1.6	0.1
Hypothyroidism (self reported)	1.4	3.2	7.9	-0.8	1.3	1.6	0.4	1.0	0.6	1.4	1.5	2.8	2.7	2.4	2.6
Relative age of first facial hair	1.4	2.8	9.7	-1.4	2.2	0.8	1.1	3.1	1.7	2.5	0.8	1.6	1.5	0.9	0.3
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	5.6	-0.3	1.9	1.5	0.8	1.4	-0.2	1.3	1.5	2.4	0.8	1.5	1.2
Taking other prescription medications	1.4	2.2	5.5	1.7	-0.8	-0.5	0.4	-0.6	-0.9	-1.5	-1.6	-2.3	-2.3	-1.5	-2.0
Had menopause	1.4	1.8	6.7	0.0	1.1	1.0	2.6	0.3	1.2	1.5	2.0	2.0	0.6	0.2	0.6
Pain all over the body in last month	1.4	1.5	3.3	1.6	0.5	1.1	1.2	1.3	1.1	1.5	1.0	0.7	0.6	1.2	1.8
Medication: Ramipril	1.4	1.8	5.1	1.5	0.6	1.5	1.7	1.1	1.0	0.6	1.7	1.3	1.0	0.9	2.2
Alcohol intake versus 10 years previously	1.4	2.1	6.8	2.5	-1.8	-0.6	0.3	-0.2	1.9	-1.2	-0.5	-2.6	-1.1	-0.9	0.9
Mouth/teeth dental problems: Dentures	1.4	2.4	11.7	3.4	-0.9	1.0	0.8	-1.0	1.4	-0.5	2.5	-1.7	-0.6	-1.5	-0.3
Breastfed as a baby	1.4	1.7	4.7	-1.7	-2.2	-1.3	-1.3	-1.4	-1.1	-0.5	-2.1	-0.0	-1.1	-0.9	-0.2
Medication: Seretide 50 evohaler	1.4	1.6	5.0	1.0	-0.8	-1.0	-0.6	-2.1	-2.2	-0.9	-0.5	-1.5	-1.7	-0.2	-1.0
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.2	-0.0	-0.4	-1.8	-0.7	-2.1	-1.9	-1.9	0.2	-1.3	-0.7	-0.9	-1.1
Alzheimer’s Disease (including proxy)	1.3	1.9	6.0	-1.7	0.0	-2.4	-1.4	0.6	-1.3	-0.6	-1.7	-0.1	0.6	0.0	-2.4
Hand grip strength (left)	1.3	3.3	13.1	3.6	-2.5	1.8	0.2	0.5	1.0	-1.4	-1.0	-2.1	-2.1	-1.0	1.9
Sensitivity / hurt feelings	1.3	2.2	5.0	0.8	2.2	1.2	0.9	1.4	2.1	1.5	2.2	1.0	1.8	0.5	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.2	12.0	-2.6	-2.6	-3.5	-2.2	-1.1	-2.6	-1.3	-2.8	0.3	-1.0	0.2	1.2
Birth weight	1.3	2.8	7.7	0.2	-2.7	-1.4	-1.5	-1.3	0.2	-1.4	-2.8	-2.3	-1.1	-1.9	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	6.0	-0.7	0.2	-2.5	0.0	-1.1	-1.2	-1.5	-0.3	-1.2	0.6	-0.1	-2.3
Ever taken oral contraceptive pill	1.3	1.4	3.8	0.8	-1.9	-0.1	-1.8	-1.3	-1.4	-0.8	-1.9	-0.9	0.2	0.3	0.5
Medication: Atorvastatin	1.3	1.6	3.8	-0.4	0.8	1.4	-0.7	1.4	1.8	2.0	0.7	1.4	1.2	1.2	1.2
Illnesses of father: High blood pressure	1.3	1.6	9.8	3.1	-0.1	1.6	-1.3	-0.1	1.1	-0.1	1.2	-1.3	-0.5	0.1	0.1
Lupus	1.2	1.8	4.3	-0.5	-0.9	-0.7	-1.3	-0.6	-0.2	-1.7	-2.1	-1.4	-1.4	-1.8	-2.0
Vitamin and mineral supplements	1.2	1.7	10.1	-0.1	-0.2	-1.8	0.3	-0.7	-0.1	-0.9	0.5	-1.0	-0.5	-2.0	-3.2
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	7.0	-0.3	1.0	1.3	-1.0	1.3	0.0	2.3	1.5	2.4	1.1	2.3	2.6
Illnesses of siblings	1.2	1.7	7.4	-1.3	-1.3	-1.6	-2.7	-0.5	-1.0	-0.5	-2.0	-0.7	-0.7	-0.8	-0.3
Falls in the last year	1.2	1.7	4.7	-0.6	-0.2	1.5	-0.1	0.1	2.1	0.7	0.6	1.5	1.3	1.9	2.2
Forced expiratory volume in 1-second (FEV1)	1.2	3.9	9.8	-0.9	-3.1	-2.7	-2.1	-1.5	-2.3	-1.7	-2.9	-0.6	-1.2	0.1	1.9
Pulse rate	1.2	2.1	4.0	-1.5	1.8	2.0	0.4	1.7	1.2	1.6	0.4	1.8	1.2	1.7	0.5
Exposure to tobacco smoke at home	1.2	1.4	3.4	0.1	-1.6	-1.2	1.0	-1.4	-0.8	-1.8	-1.0	-0.6	-0.9	-1.8	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	6.0	-1.4	2.5	0.1	0.8	2.1	1.5	1.5	0.1	1.3	1.6	1.0	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	5.0	0.1	1.1	1.9	1.3	0.9	0.5	1.0	2.2	1.0	1.5	0.4	0.7
Had major operations	1.2	1.4	4.9	-0.6	1.2	0.9	0.6	0.8	-0.4	1.0	-0.0	1.1	1.3	1.9	2.2
Leg pain on walking	1.2	1.5	5.6	0.7	-1.3	-1.4	-1.2	-0.7	-0.8	-2.0	-1.3	-2.4	-0.5	0.4	0.1
Eye problems/disorders: Glaucoma	1.2	1.4	7.3	0.4	-1.9	-1.4	-0.9	-2.7	-0.6	-1.3	-0.5	-0.7	-0.8	-0.3	-0.1
Alzheimer’s Disease (in father)	1.1	1.2	4.5	-0.9	-0.6	-2.1	-0.0	-0.8	-1.5	-0.7	-0.7	0.4	-0.3	-0.8	-2.0
Triglycerides	1.1	1.7	4.5	2.1	0.8	1.9	1.5	1.6	1.9	0.2	1.4	0.2	0.5	0.2	1.1
Serious illness, injury or assault to yourself	1.1	1.4	8.8	0.4	-0.2	0.6	0.3	-0.4	-0.6	-0.6	-0.6	0.7	1.1	2.0	3.0
Fluid intelligence score	1.1	2.3	4.5	0.8	-1.8	-0.7	-1.2	-1.4	-1.5	-1.8	-1.4	-2.1	-1.7	-1.9	-1.4
Loud music exposure frequency	1.1	1.2	3.2	0.4	-0.9	-0.9	-1.3	-0.7	-1.5	-0.7	-0.8	-1.8	-0.8	-0.3	-1.7
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	5.8	-1.2	1.5	0.9	1.0	1.0	0.9	1.2	2.0	2.4	1.8	1.4	1.1
Chronic bronchitis/emphysema (mother)	1.1	1.2	3.3	1.8	1.1	0.2	-0.2	1.6	1.4	0.4	0.4	-1.5	-0.0	-0.4	-1.8
Health satisfaction	1.1	1.5	6.3	-0.6	0.3	-0.5	2.5	0.2	0.9	1.0	0.7	1.8	1.1	1.3	1.5
Emphysema/chronic bronchitis	1.1	1.3	3.3	0.7	-0.9	-0.2	-0.9	-0.2	0.2	-0.3	-1.1	-1.6	-1.8	-1.5	-1.8
Medication: Allopurinol	1.1	1.4	4.4	-0.1	-0.4	-1.3	-1.3	-1.5	-2.1	-1.3	-0.2	-1.0	-0.9	-1.0	-1.6
Hypertension (Self-reported)	1.1	3.1	9.8	2.3	0.3	2.0	3.1	2.4	1.8	-1.1	-0.2	0.3	0.2	0.7	2.7
Mood swings	1.1	2.1	5.2	2.3	0.5	-0.4	0.4	0.0	-0.8	-2.1	-0.8	-2.3	-1.2	-1.4	-2.2
Loneliness, isolation	1.1	1.5	3.2	0.1	-1.4	-1.7	1.1	-1.4	-1.0	-1.4	-1.8	-1.3	-0.2	-1.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	7.9	-2.8	1.2	-2.3	-0.5	1.3	-0.9	1.2	-0.0	1.7	2.0	1.6	-0.4
Worry (Nagel 2018)	1.0	2.1	11.6	-0.7	2.3	-1.6	-0.2	0.8	-1.2	0.7	1.0	0.5	0.1	-1.1	-3.4
Mean Putamen Volume	1.0	1.2	5.9	1.3	-0.6	-1.1	-0.6	-1.0	0.4	-0.8	0.1	-2.4	0.2	-0.6	-1.5
Townsend deprivation index at recruitment	1.0	1.4	4.8	0.5	0.7	1.4	0.5	1.0	1.3	0.8	0.8	0.3	1.6	1.4	2.2
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.5	1.9	0.7	0.8	-0.4	-0.8	1.0	-0.3	1.8	-0.7	-0.0	-0.4	-1.7
High blood pressure	1.0	2.9	10.3	2.5	0.0	1.6	3.2	2.1	2.0	-1.2	-0.3	-0.2	-0.0	0.4	2.3
Happiness	1.0	1.3	4.1	-2.0	0.3	-0.3	0.2	0.5	-0.9	0.5	-1.0	1.6	1.5	1.5	1.2
Standing height	1.0	10.2	28.9	0.8	-5.3	-2.2	-1.1	-3.2	-1.9	-5.2	-3.5	-0.8	-2.1	0.1	5.4
Length of working week for main job	1.0	1.1	2.8	-0.0	-1.1	-1.1	-0.6	-1.4	-1.4	-1.5	-1.7	-1.1	-0.1	-0.1	0.4
Medication: Amlodipine	1.0	1.3	2.6	0.9	1.2	1.6	0.8	1.6	0.0	0.2	1.4	1.4	0.8	1.1	1.5
Eye problems/disorders: None of the above	1.0	1.1	3.9	1.7	0.4	0.3	-0.6	2.0	1.3	0.9	-0.7	-1.4	0.0	-0.2	-1.0
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	6.7	2.6	1.2	1.8	-0.3	-0.4	-2.1	-0.3	1.1	-1.4	0.1	0.0	-0.5
Mother’s age at death	1.0	1.3	4.0	-2.0	-0.4	-0.8	1.4	-0.9	-1.7	-0.8	-0.7	1.3	0.1	1.0	0.9
Vascular/heart problems diagnosed by doctor	1.0	2.6	7.8	-2.3	-0.1	-1.5	-2.8	-2.1	-2.0	0.5	0.1	0.1	-0.2	-0.5	-2.5
Neuroticism (2016)	0.9	1.3	6.7	1.1	1.7	0.1	2.6	1.0	0.3	-0.8	0.9	0.7	1.4	0.3	-0.0
Chronotype (morning person)	0.9	2.1	6.1	2.5	-1.9	-0.3	0.7	-1.5	-0.4	-2.2	-0.4	-1.6	-1.6	-1.5	0.0
Hand grip strength (right)	0.9	2.4	9.1	3.0	-1.8	1.9	-0.1	0.2	0.6	-1.6	-0.5	-1.4	-1.4	-0.4	2.5
High blood pressure (mother)	0.9	1.3	6.5	2.6	-0.8	1.7	-0.9	0.0	-0.6	-1.1	0.2	-0.9	-0.5	0.1	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	3.8	-1.1	1.9	-1.0	0.1	0.4	-1.1	0.9	1.4	1.3	1.9	0.9	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.8	1.6	-1.7	-0.4	0.5	-0.6	1.0	-1.0	-0.8	-1.5	-0.5	-1.5	0.2
Prospective memory result	0.9	1.1	3.9	-1.3	0.6	-1.2	2.0	0.0	-0.8	0.2	-0.1	1.0	1.2	1.3	0.4
Lung cancer (father)	0.9	1.1	4.2	-0.5	-1.2	-1.2	0.3	-0.1	0.1	-0.8	-2.0	-1.1	-1.0	-1.3	-1.1
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.9	1.0	1.2	1.1	-0.1	0.0	1.2	1.1	2.0	0.7	0.8	1.1	1.3
Headache pain in last month	0.9	1.6	5.3	0.9	1.5	-0.0	2.3	0.6	2.3	1.4	1.5	0.1	0.9	-0.5	-0.3
Glaucoma (self-reported)	0.9	1.1	3.3	0.5	-1.5	-0.6	-1.6	-1.8	-0.4	-1.2	-1.1	-0.6	-0.4	0.4	0.7
Exposure to tobacco smoke outside home	0.9	1.2	3.1	-0.1	1.4	0.4	-0.1	1.3	1.5	0.9	0.3	1.0	1.8	1.6	1.0
Medication: Blood pressure	0.9	1.6	6.3	1.4	0.6	1.2	1.6	1.0	1.0	-0.8	0.4	0.9	1.1	1.5	2.5
Medication: Omeprazole	0.9	1.1	4.8	0.6	-0.2	-1.4	-0.1	0.0	-0.0	-0.6	-0.8	-2.1	-0.3	-0.7	-2.2
Age at last live birth	0.9	1.3	4.9	-0.7	1.2	-0.4	1.7	-0.6	-0.1	-0.0	1.7	2.2	1.1	0.6	0.9
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	8.3	0.4	1.0	0.1	1.1	0.2	-0.5	-0.9	0.6	-0.6	-0.4	-1.0	-2.9
Medication: Paracetamol	0.9	1.4	4.5	1.0	1.1	0.2	2.1	1.5	1.7	1.6	0.9	0.0	1.1	0.3	0.2
Ever had prostate specific antigen (PSA) test	0.9	1.0	5.2	-0.9	0.2	0.5	-0.1	1.2	0.1	0.9	-0.9	1.4	0.4	1.1	2.3
Ever depressed for a whole week	0.9	1.1	3.3	-1.8	-0.4	-1.5	-1.3	0.7	-0.4	-0.4	-1.3	-0.2	0.0	-0.8	-1.7
Neuroticism (Nagel 2018)	0.8	1.9	7.9	1.6	0.6	-1.5	-0.6	-0.7	-0.8	-1.4	-0.3	-2.0	-0.5	-1.6	-2.8
Alzheimer’s Disease (in mother)	0.8	1.0	2.1	-1.4	0.2	-1.3	-1.3	1.2	-0.0	-0.1	-1.2	0.1	1.4	0.9	-0.8
Rheumatoid Arthritis	0.8	1.2	4.3	2.1	-0.6	0.5	1.0	0.5	2.1	0.3	0.8	-0.9	0.1	-1.1	-0.8
Height	0.8	15.7	53.7	2.0	-7.0	-0.6	-2.2	-3.1	-1.0	-5.7	-4.9	-1.2	-2.8	0.0	7.3
Waist Hip Ratio (WHR)	0.8	3.6	12.7	-0.5	-0.2	-1.3	3.6	1.0	2.7	-0.5	-0.5	2.2	1.9	1.8	2.8
Type 2 Diabetes (T2D) (2018)	0.8	1.5	4.2	2.1	-0.4	1.3	2.0	-0.2	0.3	-1.6	-0.8	0.4	0.4	1.2	1.8
Neuroticism	0.8	1.8	5.5	2.3	0.9	-1.2	1.1	0.1	-0.1	-1.1	0.4	-1.6	-0.2	-2.0	-2.3
Hearing difficulty/problems: Yes	0.8	1.2	4.1	0.5	1.2	1.2	1.3	0.2	1.1	0.6	2.0	1.3	1.1	0.4	0.6
Medication for hormone replacement therapy	0.8	0.9	2.5	-1.5	0.1	-1.2	0.2	-0.5	-0.3	0.2	0.7	1.3	1.6	1.0	0.8
Diabetes (mother)	0.8	1.0	5.8	1.3	-0.1	-0.1	2.4	0.3	0.8	-1.4	0.5	0.1	0.4	0.3	1.1
Severe depression (siblings)	0.8	0.9	2.4	1.1	1.0	1.1	0.8	0.9	1.1	0.1	-0.6	0.1	1.0	1.5	1.2
Average weekly fortified wine intake	0.8	0.9	3.1	-0.9	0.9	1.8	-1.1	1.0	0.1	0.8	-0.9	0.9	-0.3	0.4	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	3.0	-0.1	-0.8	-1.7	1.4	-0.8	-1.6	-1.5	-0.6	-0.6	0.6	-0.8	-0.5
Qualifications: CSEs or equivalent	0.8	1.0	2.3	1.5	-0.1	1.0	-1.5	0.1	1.1	0.9	0.8	-1.2	1.1	-0.5	1.0
Supplements: Glucosamine	0.8	1.0	3.1	1.8	-0.2	1.2	-0.7	-0.8	-1.0	-1.8	-0.0	-1.1	-0.8	-0.0	0.4
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.9	-2.0	1.0	-1.1	-0.1	1.0	0.5	0.6	-0.6	1.0	0.6	0.2	-1.6
Father’s age at death	0.8	1.1	2.5	-1.0	-1.5	-1.4	-1.3	-0.5	-1.6	-0.4	-1.4	-0.7	-0.9	-0.2	-0.3
Worrier / anxious feelings	0.8	1.5	9.6	-0.2	2.1	-1.1	-0.4	0.9	-0.1	-0.0	0.1	-0.4	-0.6	-0.8	-3.1
Noisy workplace	0.8	1.0	4.3	0.1	-0.6	-0.7	-0.3	0.4	-1.5	-1.0	-2.1	-1.4	-0.9	-0.2	-0.4
Peak expiratory flow (PEF)	0.8	1.9	9.8	-0.8	-0.8	0.2	0.3	0.2	-0.7	0.3	-1.6	1.6	0.8	2.1	3.1
Pulse wave reflection index	0.8	1.0	3.7	1.9	-0.1	-0.2	1.5	0.8	-1.0	-0.1	-0.7	-1.0	-0.9	-0.2	1.4
Medication: Paracetamol	0.8	1.4	4.5	1.7	0.5	-0.0	2.1	1.1	2.1	0.8	0.7	-1.0	1.0	-0.5	-0.3
Pulse wave peak to peak time	0.8	1.0	3.1	-0.7	-1.1	-0.6	-1.8	-1.4	-0.7	-1.4	-0.4	-0.6	-0.1	-0.7	-0.9
Mouth/teeth dental problems: Loose teeth	0.8	1.0	4.0	1.0	-1.0	-0.7	-0.0	-1.7	-2.0	-1.2	-0.1	-0.5	-0.6	-0.2	-0.3
Medication for pain relief, constipation, heartburn	0.8	1.4	4.9	-1.0	-0.1	1.2	-2.2	-0.7	-2.1	0.2	0.4	1.6	-0.6	0.9	1.0
Heart disease (mother)	0.8	1.0	4.1	2.0	-0.3	-0.5	-0.2	-0.6	-1.0	-0.6	-0.3	-1.9	-0.5	-0.4	-1.1
Pulse rate, automated reading	0.8	2.6	6.5	-1.2	1.6	2.4	1.5	1.9	2.0	1.1	0.5	2.6	0.3	1.4	1.5
Hearing aid user	0.8	0.9	4.8	0.5	-0.1	-0.1	2.2	0.6	1.4	0.9	0.5	0.1	0.8	-0.8	-0.8
Tinnitus: Yes, now most or all of the time	0.8	1.0	3.3	-0.7	1.0	0.5	1.8	0.4	-1.0	0.1	0.3	1.6	1.1	1.1	0.6
Medication: Blood pressure	0.8	1.5	6.6	2.5	-0.6	0.5	2.6	1.1	0.8	-0.7	-0.1	-0.9	-0.8	-0.9	0.3
Average weekly beer plus cider intake	0.8	1.2	4.4	0.6	1.5	1.2	-0.4	2.1	1.1	0.1	1.6	-0.2	1.1	0.9	-0.4
Fractured/broken bones in last 5 years	0.8	1.0	3.0	1.7	0.1	1.1	-1.0	-0.8	-1.3	-0.5	0.9	-1.5	-0.9	-0.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.5	1.0	1.0	-0.2	0.0	1.3	0.9	0.1	-0.8	-1.9	0.3	-0.1	-1.8
Pain experienced in last month	0.8	1.3	3.4	-1.8	-1.1	-0.7	-1.4	-1.3	-1.8	-1.0	-1.2	0.3	0.0	0.9	0.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	3.8	-2.0	0.1	-1.3	1.0	-0.5	-0.3	0.4	1.3	1.6	1.1	0.5	0.0
Bipolar Disorder (2018)	0.7	1.2	5.0	-2.2	0.0	-0.4	-0.4	0.4	-0.9	1.4	-0.5	2.1	0.7	0.7	-0.1
LDL Cholesterol	0.7	1.2	5.3	-0.7	2.3	1.0	0.6	0.6	0.0	1.0	1.3	1.0	1.2	1.0	-0.6
Hayfever, allergic rhinitis or eczema	0.7	1.6	5.9	0.0	-1.1	-0.1	-2.1	-1.8	-1.5	0.1	-0.3	-0.4	-2.4	-0.7	-0.9
Medication: Levothyroxine sodium	0.7	1.1	4.2	-0.7	0.6	1.1	1.5	0.2	0.6	0.1	2.0	1.8	0.7	0.4	0.9
Sitting height	0.7	4.7	16.7	-1.7	-1.6	-2.3	-0.9	-1.7	-3.0	-3.0	-0.6	1.2	0.6	2.2	4.1
Chronic bronchitis/emphysema (father)	0.7	0.8	2.4	0.7	-0.4	-0.4	1.3	-0.1	-0.4	-0.8	-0.5	-1.5	-0.8	-1.1	-1.4
Pulse wave Arterial Stiffness index	0.7	0.8	2.1	0.7	0.7	0.6	1.4	1.3	0.7	1.3	0.2	0.6	-0.1	0.7	1.4
Blood clot in the leg (DVT)	0.7	0.9	2.9	-1.7	-0.1	-1.5	1.2	-0.7	-0.3	0.0	1.2	1.3	0.9	0.1	-0.2
Average weekly red wine intake	0.7	1.0	4.8	-2.2	-0.5	-0.4	0.0	-1.6	-0.2	-0.5	0.3	1.7	0.4	0.9	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.9	-0.3	-0.2	-0.0	1.0	0.2	-1.1	-0.2	-1.1	0.9	0.2	1.1	1.7
Friendships satisfaction	0.7	0.8	2.4	-1.0	0.1	-0.4	0.8	0.4	0.5	1.6	-0.5	1.4	0.7	0.6	1.5
Back pain experienced in last month	0.7	1.0	4.0	0.4	-0.9	-0.3	-0.6	-0.1	0.1	-0.8	-1.2	-2.0	-0.8	-1.4	-1.5
Medication: Gliclazide	0.7	0.8	2.9	0.8	-0.7	1.4	-0.6	-0.3	0.3	-0.3	-0.8	-0.3	0.8	1.5	1.7
Guilty feelings	0.7	1.0	5.9	1.0	0.1	-1.0	2.4	-0.4	1.6	-0.3	0.6	0.1	0.8	-0.1	0.7
Commuting to job workplace: Public transport	0.7	0.8	1.9	0.2	0.5	1.0	0.6	1.3	1.4	1.2	0.6	1.0	0.5	0.6	0.9
Number of operations (self-reported)	0.7	1.1	3.6	1.9	1.0	1.6	1.2	0.8	1.5	0.9	0.8	-0.4	-0.1	0.6	0.0
Verbal and Numeric Reasoning (VNR)	0.6	1.5	4.4	0.4	-1.2	-1.5	0.1	-1.0	-0.4	-1.5	-0.4	-1.6	-1.2	-2.1	-1.2
Lung FVC	0.6	3.1	8.2	-2.9	-2.0	-2.8	-2.6	0.6	-0.8	0.5	-2.7	0.4	-0.9	-0.5	-0.2
Average weekly spirits intake	0.6	0.7	4.0	0.6	0.1	2.0	-1.5	0.6	0.2	0.6	0.4	-0.2	0.2	0.6	0.9
Supplements: Zinc	0.6	0.7	2.8	-0.2	-1.2	-0.7	-0.3	-1.4	-1.7	-0.3	-0.8	-0.4	-0.2	-0.0	0.2
Current tobacco smoking	0.6	1.0	3.7	1.6	0.9	1.9	0.5	1.5	0.9	0.2	0.4	-0.5	0.3	0.0	1.1
Allergy	0.6	1.3	4.0	-0.7	1.4	0.1	1.6	1.5	1.0	-0.3	-0.1	0.7	2.0	1.2	1.2
Qualifications: A levels/AS levels or equivalent	0.6	1.2	8.9	-3.0	0.3	-1.0	-0.1	0.3	1.1	0.2	-0.8	1.6	-0.1	-0.2	-0.1
Migraine (self-reported)	0.6	0.7	2.9	0.1	1.1	-0.4	0.5	0.3	1.1	-0.0	1.2	-0.4	-0.2	-0.9	-1.7
Mean time to correctly identify matches	0.6	1.1	3.6	-0.4	1.8	0.6	1.6	0.6	0.2	1.9	0.8	1.4	0.6	0.4	-0.6
Chest pain or discomfort	0.6	0.8	3.3	-0.5	-0.1	-0.7	0.1	-0.1	-0.8	0.1	-0.1	1.0	1.4	1.4	1.8
Illnesses of siblings: Diabetes	0.6	0.7	3.9	1.0	0.3	1.0	1.0	-0.4	-0.0	-0.4	2.0	0.6	0.4	-0.3	0.7
Handedness (chirality/laterality): Left-handed	0.6	0.8	3.2	0.5	0.0	0.7	1.4	-0.3	1.8	0.5	1.3	0.9	-0.1	-0.3	0.7
Qualifications: nursing, teaching	0.6	1.0	3.4	-1.9	0.2	0.2	0.0	0.4	-0.1	-0.7	-1.5	1.6	-0.9	0.7	1.2
Breast cancer (self-reported)	0.6	0.7	3.1	0.1	-1.1	-0.1	-1.8	-1.4	0.4	0.1	-1.1	-0.8	-0.7	-0.2	-0.1
Miserableness	0.6	1.0	4.7	2.2	0.4	0.4	0.2	0.4	0.0	-2.0	-0.4	-1.3	0.4	-0.3	1.0
Medication: Lisinopril	0.6	0.7	2.5	1.5	-0.2	1.0	0.9	0.8	0.4	-1.0	-0.2	0.3	-0.2	0.5	1.6
Irritable Bowel Disease (IBD)	0.5	1.2	3.7	1.4	0.2	-0.1	0.5	0.6	-0.6	-1.8	-0.6	-1.9	1.0	-0.2	-1.7
Age at First Birth	0.5	0.8	4.4	-2.1	-0.6	-1.1	-0.0	-0.4	-0.3	-0.5	-1.4	0.9	0.1	0.4	0.4
Smoking Status	0.5	1.1	5.4	2.3	0.2	1.6	0.8	1.1	0.9	0.8	0.3	-1.3	0.3	-0.1	0.3
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	3.7	-0.8	-0.9	-0.8	0.8	-0.1	-1.9	-0.0	-0.4	0.5	0.1	-0.1	-0.1
Qualifications: None of the above	0.5	1.0	5.6	2.4	0.5	0.9	1.5	0.4	-0.2	0.3	1.2	-0.7	0.0	0.4	-0.8
Diabetes (self-reported)	0.5	0.7	2.1	0.6	-0.6	0.5	0.9	-0.7	-1.0	-1.5	-0.2	0.2	0.7	1.4	0.9
Neuroticism score	0.5	1.1	2.8	1.7	1.1	-1.0	1.3	0.3	0.0	-1.0	0.5	-1.0	0.3	-1.2	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.1	0.2	1.0	-0.1	1.3	0.6	0.6	-0.0	0.9	0.8	1.4	1.5	0.6
Depression (self-reported)	0.5	0.7	2.6	-0.4	0.9	-0.6	0.8	0.4	0.9	-0.0	-0.7	-0.6	-0.9	-0.9	-1.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.7	1.0	-0.8	-0.7	0.4	-0.8	-0.6	-1.1	-0.8	-0.0	-1.3	-0.0	0.1
Number of full brothers	0.5	0.7	2.4	-0.9	-0.9	-0.2	0.1	-0.1	-1.4	-0.3	-0.2	0.3	1.2	0.7	1.5
Diabetes diagnosed by doctor	0.5	0.8	2.2	1.3	-0.3	1.5	1.0	-0.0	-0.4	-1.0	0.0	0.1	0.6	1.2	1.3
Commuting to job workplace: Walk	0.5	0.5	1.8	-0.7	0.5	0.5	0.9	0.2	0.2	-0.4	-0.2	1.3	0.7	0.7	1.1
Smoking status: Current	0.5	0.8	3.0	1.1	0.4	1.7	0.5	1.5	0.5	0.1	-0.1	-0.1	0.3	0.3	1.5
Number of self-reported non-cancer illnesses	0.5	0.8	3.0	0.5	0.8	0.6	1.6	1.2	1.7	0.5	0.6	0.6	0.6	0.6	0.0
Wears glasses or contact lenses	0.5	0.6	2.9	1.7	-0.0	1.3	-0.8	-0.4	-0.3	0.4	0.1	-0.1	-0.9	-0.2	0.3
Ever smoked	0.5	0.9	3.4	1.0	0.3	0.2	1.8	0.8	-0.7	0.9	-0.4	0.2	0.7	0.9	1.6
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.8	-0.9	-0.3	-0.5	0.5	-0.0	-0.7	0.3	-0.1	1.1	1.1	1.1	1.3
Pack years of smoking	0.5	0.7	3.0	-0.4	0.1	0.0	0.2	-1.7	-0.5	-0.7	1.1	-0.6	0.2	-0.9	-1.4
Depression (Nagel 2018)	0.4	0.6	2.1	-0.4	-0.2	-0.6	0.1	-0.2	-1.4	-0.4	-1.4	-1.0	-0.2	-0.6	-0.7
Crohns Disease (2012)	0.4	0.7	3.1	-0.3	1.8	0.8	0.8	1.2	-0.3	0.2	0.7	0.5	0.9	0.3	-0.4
Fasting Glucose	0.4	0.5	2.5	0.0	1.6	0.3	-0.6	0.2	0.0	0.9	1.2	0.1	0.6	0.2	-0.5
HbA1C	0.4	0.5	2.7	-0.1	-0.3	-0.7	-0.3	-0.7	1.6	0.2	1.3	-0.4	0.0	-0.3	-0.4
HDL Cholesterol	0.4	0.7	3.1	-0.6	-0.0	-0.4	-0.5	0.1	-1.8	-1.2	-1.4	-0.7	-0.7	-0.1	-0.5
Number of treatments/medications taken	0.4	0.7	4.3	2.1	0.4	0.6	1.3	0.5	0.9	0.1	-0.0	-0.6	0.0	0.4	0.2
Frequency of depressed mood in last 2 weeks	0.4	0.5	2.1	0.3	0.1	-0.3	-0.1	-0.1	-0.1	0.2	-0.4	-1.4	0.2	-1.3	-1.5
Angina	0.4	0.5	1.7	0.6	-1.0	-0.4	0.3	0.9	-0.3	-0.2	-1.0	-0.4	0.7	0.2	1.3
Medication: Co-codamol	0.4	0.5	1.7	0.8	-0.7	0.3	0.7	-0.1	1.2	1.3	-0.4	-0.5	-0.2	-0.3	-0.2
Medication: Metformin	0.4	0.6	1.6	1.3	-0.5	1.2	-0.1	-0.9	-0.1	-0.7	0.3	-0.2	1.0	0.7	1.2
Pack years adult smoking proportion	0.4	0.7	2.5	-0.3	-0.2	-0.1	-0.3	-1.6	-0.7	-0.9	0.5	-1.0	0.2	-0.9	-1.3
Stomach or abdominal pain in last month	0.4	0.5	1.8	-0.2	0.8	-0.4	-0.4	0.3	0.3	0.5	1.3	0.3	1.2	0.1	-0.9
Financial difficulties in last 2 years	0.4	0.6	2.5	-0.6	-1.1	0.2	-1.0	-0.4	-0.2	0.1	-1.6	-0.2	0.1	0.0	1.1
Heart attack	0.4	0.5	1.2	-0.8	-0.4	-0.7	0.5	-0.1	-0.9	0.2	-0.1	0.7	1.1	0.9	1.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.1	-0.3	0.6	-0.8	-1.3	0.4	-1.4	-0.5	0.1	-0.1	-0.8	-0.2	-0.9
Medication: Ibuprofen	0.4	0.5	1.7	1.3	-1.2	-0.3	0.5	-0.2	1.0	0.0	-0.3	-0.8	-0.0	-1.0	-0.1
Ever had bowel cancer screening	0.4	0.5	1.7	-0.4	0.4	-0.5	1.3	0.6	1.1	-0.9	-0.2	0.7	0.4	-0.3	-0.0
Osteoporosis (self-reported)	0.4	0.5	1.8	0.3	-1.0	0.7	0.0	-0.1	-0.8	-1.0	-0.9	-0.1	-1.3	-0.2	0.2
Irritability	0.4	0.6	1.9	1.4	-0.3	-0.5	0.7	0.3	-1.3	-0.8	-0.5	-1.0	0.3	-0.8	-0.3
Age started oral contraceptive pill	0.4	0.5	2.3	-0.1	0.0	-0.3	1.2	-0.5	0.2	0.2	-0.3	-0.3	-1.5	-0.9	-1.2
Myopia	0.4	0.6	4.0	-0.6	0.5	2.0	-0.5	0.5	0.2	0.7	-0.1	0.7	0.2	0.1	0.8
Alcohol drinker status: Previous	0.4	0.5	2.0	0.1	-0.2	-0.1	0.9	0.0	0.7	-0.3	-0.1	-0.1	1.3	0.6	1.4
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.1	0.4	-1.4	-1.4	-0.7	-1.3	0.1	-1.4	-0.3	-1.2	-0.3	-1.4	-0.2
Schizophrenia vs Biploar Disorder	0.3	0.4	1.8	-0.2	0.0	-0.3	1.3	0.5	0.0	0.2	0.2	-0.3	-0.7	-0.8	-1.0
Crohns Disease (2017)	0.3	0.6	3.0	-0.8	0.6	-0.1	0.6	0.9	-0.4	-0.1	-0.1	0.9	1.7	0.9	0.3
Reaction Time	0.3	0.7	2.7	0.6	1.4	0.6	0.9	0.6	0.5	1.6	0.6	0.1	0.1	-0.3	-0.7
Allergy or Eczema	0.3	0.9	3.7	-1.1	-0.0	-0.1	-1.9	-1.1	-1.2	0.5	0.1	0.4	-1.4	-0.0	-0.8
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.2	-0.0	0.6	1.1	-0.5	0.6	0.9	0.7	-0.0	0.6	0.2	0.6	0.3
Medication: Atenolol	0.3	0.3	1.3	-0.4	-0.2	-0.5	1.1	-0.3	0.7	0.1	0.2	0.6	0.8	0.7	0.5
Past tobacco smoking	0.3	0.6	3.1	-1.8	0.0	-0.2	-1.0	-0.4	-0.5	-0.3	0.1	1.2	-0.6	-0.4	-0.5
Illnesses of mother	0.3	0.3	1.6	-1.3	0.6	-0.3	0.7	-0.1	-0.4	0.6	-0.0	0.8	0.1	-0.0	-0.0
Hair/balding pattern: Pattern 4	0.3	0.8	2.9	0.9	-0.6	0.4	-0.3	-0.5	-1.0	-0.8	-0.9	-0.8	-1.7	-0.8	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.4	-1.2	-0.4	-0.2	-0.5	0.0	0.4	0.5	0.2	0.9	0.9	0.1	0.3
Angina (self-reported)	0.3	0.5	2.0	0.4	-0.8	-0.1	0.2	0.8	-0.5	-0.3	-1.0	-0.2	0.7	0.4	1.4
Overall health rating	0.3	0.7	4.3	0.1	0.4	-0.5	2.1	1.2	0.6	-0.4	-1.0	-0.7	0.3	0.7	0.2
Illnesses of father: Heart disease	0.3	0.4	2.0	0.2	0.4	0.3	1.4	-0.3	-0.5	0.1	0.6	0.5	0.9	0.7	0.7
Smoking status: Previous	0.3	0.4	1.4	1.2	-0.3	-0.3	0.4	-0.4	0.6	0.3	0.2	-1.2	0.8	0.3	-0.4
Mineral and other dietary supplements	0.3	0.4	2.7	-0.8	0.4	-0.8	0.1	0.1	0.1	0.0	-0.2	0.2	-0.2	-0.6	-1.6
Osteoarthritis (self-reported)	0.3	0.4	1.8	0.1	0.0	-0.3	-1.4	0.3	1.4	0.3	-0.5	-0.8	0.4	0.4	-0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	-1.1	1.1	-0.0	-0.8	0.9	-0.1	0.1	-0.6	0.6	-0.0	-0.2	-0.2
Average weekly champagne plus white wine intake	0.3	0.5	2.0	-0.0	0.5	0.8	-0.1	0.7	-0.9	0.9	0.4	1.4	0.3	0.2	0.6
Financial situation satisfaction	0.3	0.4	2.1	-0.4	-0.9	-0.4	-0.8	-1.4	-0.9	-0.1	-0.3	-0.5	-0.2	-0.3	0.1
Alcohol drinker status: Never	0.3	0.4	1.3	0.2	0.2	0.4	0.6	0.2	0.9	0.3	0.2	0.8	0.3	1.0	1.1
Heart disease (siblings)	0.3	0.3	1.9	-0.4	-0.0	0.2	1.4	0.4	0.5	-0.5	0.1	0.0	0.4	0.7	0.7
Blood Platelet Count	0.2	2.3	10.8	-1.2	3.3	-0.3	1.0	0.4	-0.6	-1.7	2.9	-1.0	-0.0	0.4	-1.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.9	-0.7	-0.5	0.2	0.1	-0.0	0.6	0.3	-0.2	0.8	0.6	1.0	0.4
Had other major operations	0.2	0.3	0.8	0.6	-0.7	-0.4	-0.0	-0.1	0.7	-0.1	-0.6	-0.9	-0.9	-0.4	-0.3
Medication: Lansoprazole	0.2	0.3	1.3	0.5	0.3	0.3	0.5	0.3	0.2	0.2	0.2	-0.6	-0.2	-0.8	-1.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	2.7	-0.5	-0.6	0.2	0.1	0.4	0.1	-0.1	-1.6	0.3	-0.2	-0.0	-0.0
Worry too long after embarrassment	0.2	0.3	1.3	-0.2	0.5	-1.1	0.4	-0.1	0.1	-0.3	0.8	-0.0	0.5	-0.2	-0.6
Age at first live birth	0.2	0.4	2.4	0.1	0.1	0.3	-0.4	-0.9	0.3	0.3	0.6	1.6	-0.6	0.3	0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.3	2.6	-0.0	-0.6	0.2	0.3	0.1	-0.3	-0.1	-0.3	0.0	0.5	0.1	1.6
Major Depression (MDD)	0.1	0.1	0.6	-0.1	0.0	0.0	-0.2	0.0	0.0	0.8	0.0	0.2	0.5	0.0	0.0
Breast Cancer	0.1	0.2	0.9	0.9	0.6	-0.3	-0.1	-0.2	0.7	-0.3	0.7	-0.1	-0.3	0.3	0.1
Ovarian Cancer	0.1	0.1	0.4	0.4	0.5	0.6	0.3	0.3	-0.3	-0.3	0.4	-0.3	-0.0	0.1	-0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	1.6	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.3	0.0
Tanning	0.1	0.7	2.1	0.2	0.7	-0.7	-1.3	1.5	-0.3	0.6	-1.1	-0.7	0.6	0.6	-0.9
Hair/balding pattern: Pattern 2	0.1	0.2	1.3	-0.4	-0.1	-0.1	-1.1	0.0	0.3	-0.1	0.2	0.2	-0.1	-0.3	0.6
Number of full sisters	0.1	0.2	0.4	0.7	0.0	-0.3	0.3	-0.5	0.6	-0.6	0.6	-0.2	-0.0	0.1	0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.6	0.5	0.3	0.8	-0.7	-0.6	-0.3	-0.2	-0.0	-0.2	-0.3	0.2	0.2
Unable to work because of sickness or disability	0.1	0.2	0.9	-0.1	0.0	-0.5	0.7	0.1	0.1	0.3	-1.0	-0.0	-0.0	0.3	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.0	3.3	0.0	-1.4	-0.1	-1.4	-0.5	-1.0	0.6	-1.1	-0.7	-0.7	-1.1	-1.8

Hub : Genes

GDPD3

Models

Trait associations