Hub : Genes

GDPD5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1485	0.0471	3.0e-05	0.076	NA	0.098	NA	0.098	5.0e-06	NA	2.1e-07	NA	2.0e-07
2	GTEx	Skin Sun Exposed Lower leg	0.0920	0.0350	7.8e-04	0.053	NA	0.019	NA	0.060	3.2e-05	NA	9.5e-03	NA	1.0e-05
3	METSIM	Adipose	0.0636	0.0216	2.3e-05	0.013	0.032	0.051	0.038	0.042	3.8e-03	1.1e-05	3.8e-08	2.0e-06	5.8e-07
4	NTR	Blood	0.0408	0.0122	3.3e-06	0.020	0.021	0.022	0.023	0.020	4.5e-07	1.2e-07	9.6e-08	4.4e-08	2.5e-07
5	ROSMAP	Brain Pre-frontal Cortex	0.0359	0.0179	1.7e-02	0.002	0.003	0.001	0.002	-0.001	1.6e-01	1.1e-01	2.0e-01	1.4e-01	3.9e-01
6	YFS	Blood	0.4844	0.0410	0.0e+00	0.304	0.306	0.338	0.334	0.337	2.1e-101	1.5e-102	3.1e-115	9.4e-114	4.4e-115
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0249	0.0135	1.6e-03	0.031	0.027	0.029	NA	0.029	1.8e-04	4.8e-04	3.0e-04	NA	2.7e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.6	1.0	-0.9	0.3	-0.1	-0.9	0.9	-0.6	1.0
Bipolar Disorder or Schizophrenia	0.5	1.2	2.4	-1.5	-0.2	0.2	-1.0	1.2	-1.2	1.6
Depressed Affect (Nagel 2018)	0.1	0.3	0.8	0.2	-0.4	-0.4	0.9	-0.4	0.6	0.4
Depression (Nagel 2018)	0.4	0.6	1.0	0.6	0.9	-0.3	1.0	-0.9	0.8	-0.7
Intelligence (Savage-Jansen 2018)	0.9	2.9	5.0	1.9	1.9	1.9	2.2	-0.5	1.8	-1.1
Neuroticism (Nagel 2018)	0.1	0.2	0.4	-0.6	-0.3	-0.6	-0.5	-0.6	-0.3	0.4
Schizophrenia (2018)	0.4	0.8	1.4	-1.2	-0.5	0.4	-0.6	0.8	-1.1	1.2
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	0.8	0.2	-0.8	0.2	0.2	0.5	-0.3
Worry (Nagel 2018)	0.2	0.4	2.4	-0.3	0.1	-1.5	-0.7	-0.1	-0.1	-0.2
Alzheimer’s Disease (in mother)	0.8	0.9	2.4	-1.0	-0.7	-1.6	-0.8	-0.2	-0.5	1.2
Alzheimer’s Disease (in father)	0.3	0.4	0.6	0.5	0.7	0.7	0.7	0.1	0.5	-0.7
Alzheimer’s Disease (including proxy)	0.1	0.1	0.6	-0.0	-0.2	-0.5	0.8	-0.1	0.1	0.1
Crohns Disease (2017)	0.3	0.6	2.0	-0.0	1.2	-0.3	-0.4	-1.4	0.5	0.8
Irritable Bowel Disease (IBD)	0.2	0.4	1.2	-0.7	0.3	-0.7	-1.1	-0.0	-0.9	0.1
Ulcerative Colitis (UC)	0.4	0.7	1.4	-0.7	-0.3	-0.9	-1.0	0.8	-1.2	-0.6
Major Depression (MDD)	0.6	0.7	1.6	-0.2	-1.3	-0.9	0.2	-0.5	-1.0	-1.0
Reaction Time	0.9	1.7	3.0	0.9	0.5	1.7	1.5	1.3	1.5	-1.2
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.8	0.5	1.4	0.8	0.2	0.2	0.9	-0.2
Breast Cancer	0.4	1.1	4.8	-0.1	-1.0	0.5	1.1	2.2	0.3	0.1
Ovarian Cancer	0.2	0.2	0.5	0.0	0.6	0.5	-0.2	-0.1	0.5	0.7
Prostate Cancer	0.4	0.6	2.1	0.6	-0.0	-0.8	0.2	1.4	1.1	-0.2
Age at First Birth	5.8	8.5	12.8	3.2	2.3	2.9	3.3	-0.8	3.3	-3.6
Bipolar Disorder (2011)	0.2	0.2	1.2	-0.0	0.2	1.1	0.1	0.4	0.2	-0.2
Body Mass Index (BMI) (2010)	0.5	0.7	1.7	-0.9	-1.3	-0.0	-0.4	1.0	-0.0	0.9
Coronary Artery Disease (CAD)	1.6	1.9	3.9	1.6	1.0	1.1	1.4	-2.0	1.0	-1.3
Crohns Disease (2012)	0.8	1.3	2.6	1.1	1.6	0.6	0.9	-1.6	1.3	0.0
Mean Putamen Volume	1.7	2.0	3.1	1.7	1.7	0.7	1.1	-1.8	1.3	-1.2
Fasting Glucose	2.6	3.1	7.8	-2.1	-1.8	-1.4	-0.3	2.8	-0.7	2.0
HbA1C	0.9	1.0	3.2	-1.1	-0.7	0.6	0.1	0.8	0.9	1.8
HDL Cholesterol	0.7	1.2	3.0	-1.2	-1.1	0.4	-1.7	-0.5	-1.1	0.9
LDL Cholesterol	0.2	0.3	1.2	0.7	1.1	0.2	0.4	-0.2	0.7	-0.1
Lupus	1.2	1.8	4.4	1.3	1.8	0.4	0.2	-2.1	1.0	-1.5
Neuroticism (2016)	0.3	0.4	1.3	-0.4	-1.1	-0.4	-0.8	-0.6	-0.4	-0.7
Primary Biliary Cirrhosis	1.5	2.1	4.1	1.8	1.7	-0.0	2.0	-0.2	1.4	-1.6
Rheumatoid Arthritis	0.8	1.1	6.4	0.0	-0.0	2.5	-0.3	0.4	1.1	0.1
Schizophrenia (2014)	0.3	0.7	1.5	-1.2	-0.5	0.5	-0.6	0.8	-0.9	1.1
Triglycerides	0.2	0.3	0.8	0.3	0.7	0.3	-0.9	-0.5	-0.1	-0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.8	-0.4	-0.4	-0.9	0.2	-0.3	0.2	0.3
Ulcerative Colitis	0.6	0.8	2.7	-0.4	-0.2	-1.2	-0.2	1.6	-1.1	-0.6
Blood Eosinophil Count	0.1	0.7	1.2	-0.9	-1.1	-0.7	-1.0	0.6	-1.1	0.3
Blood Platelet Count	0.0	0.4	1.0	0.2	0.3	1.0	-0.6	-0.9	0.6	-0.3
Blood Red Count	0.5	4.5	9.6	-1.9	-2.1	-2.5	-1.0	3.1	-1.8	1.9
Blood White Count	0.2	1.1	4.3	-0.1	0.9	2.1	0.7	0.5	1.4	0.5
Heel T-Score	0.9	7.3	10.4	-2.9	-3.2	-2.7	-1.5	2.3	-3.1	2.9
BMI	0.2	1.1	2.1	1.4	1.2	-0.2	1.5	-0.1	0.9	-1.2
Height	0.5	8.7	26.6	1.0	2.0	0.5	-4.7	-5.2	-0.5	-2.5
Waist Hip Ratio (WHR)	0.2	0.8	3.8	0.2	-0.7	0.5	0.7	0.4	-0.8	-1.9
Systolic Blood Pressure	0.4	2.1	8.2	1.8	0.8	-0.1	1.6	-0.5	-0.2	-2.9
Smoking Status	0.5	1.2	2.4	1.3	0.7	0.4	1.4	-1.6	1.1	-0.9
Allergy or Eczema	0.5	1.3	3.1	0.7	1.7	-1.6	-0.3	-1.3	0.4	-1.0
Cardiovascular Disease	0.2	0.8	2.9	0.6	-0.2	1.1	1.7	0.3	0.1	-1.0
Hypothyroidism (self reported)	0.1	0.2	0.9	0.5	0.0	-0.4	0.1	-1.0	-0.3	-0.5
Respiratory disease	0.3	0.7	1.4	1.1	0.9	0.4	0.8	-0.9	0.2	-1.2
Type 2 Diabetes (T2D) (2018)	0.5	0.8	2.9	-0.4	-1.7	-1.3	0.1	0.8	-0.5	0.5
Lung FEV1/FVC ratio	1.0	5.2	15.8	2.2	2.3	0.9	1.2	-4.0	1.7	-2.3
Lung FVC	0.5	2.5	6.8	-1.0	-1.1	-2.1	1.0	1.7	0.8	2.6
Neuroticism	0.0	0.1	0.3	-0.6	-0.1	-0.1	-0.4	-0.3	-0.1	0.5
Chronotype (morning person)	0.5	1.3	4.8	0.7	1.0	1.1	1.1	-0.0	2.2	-0.0
Hair Pigment	0.0	0.9	2.7	0.7	0.4	0.4	0.6	1.5	-0.0	-1.6
Tanning	0.0	0.3	1.5	-0.5	-0.1	0.3	-0.0	-0.6	0.4	1.2
Hand grip strength (left)	0.2	0.6	1.9	0.4	1.4	0.5	-0.9	-0.4	0.2	-0.8
Number of treatments/medications taken	0.6	1.0	2.7	1.3	0.9	-0.9	0.8	0.4	0.5	-1.7
Average weekly spirits intake	0.8	1.0	1.9	0.7	0.6	1.4	1.2	-0.9	0.8	-1.1
Sensitivity / hurt feelings	0.8	1.3	2.6	-1.4	-1.6	-1.1	-1.1	0.9	-0.9	0.7
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	-0.5	0.0	-0.1	-0.3	0.3	-0.7	-0.4
Hearing difficulty/problems: Yes	2.6	4.0	7.0	-1.8	-2.6	-2.2	-2.3	0.7	-2.4	1.0
Relative age of first facial hair	0.4	0.8	2.7	-0.2	-0.6	-1.0	-1.6	-0.8	-0.8	-0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.7	-0.2	-0.5	0.5	-0.7	0.8	-0.7	-0.2
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.6	-1.1	-1.6	-1.3	-0.2	0.9	-1.1	1.4
Ever had hysterectomy (womb removed)	0.7	0.8	2.6	-1.1	-1.6	0.1	-0.5	0.5	-0.8	1.0
Systolic blood pressure, automated reading	0.2	0.5	1.7	-0.3	-0.6	-1.3	-0.1	0.5	-1.0	-0.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.7	-0.2	-0.7	-1.6	-0.0	-0.4	-0.4	0.3
Angina	1.3	1.7	5.7	1.2	0.5	-2.4	0.3	-1.2	-0.1	-1.8
Medication for hormone replacement therapy	0.1	0.1	0.4	0.4	0.7	-0.4	0.3	0.4	-0.0	-0.2
Vitamin and mineral supplements	0.7	0.9	4.6	0.1	-0.3	-0.7	-0.3	-2.1	0.3	1.1
Supplements: Zinc	0.4	0.4	1.4	-0.2	-0.4	-0.8	0.2	1.2	-0.5	0.4
Medication: Co-codamol	0.2	0.2	0.7	0.1	-0.6	-0.8	-0.3	-0.3	-0.1	-0.6
Medication: Metformin	0.2	0.3	1.0	-0.2	-1.0	-0.6	0.7	0.2	-0.1	0.5
Diabetes (father)	0.7	0.9	1.8	1.3	0.4	1.1	0.8	-0.9	1.1	-0.6
Diabetes (mother)	0.5	0.6	2.6	-1.1	-0.8	0.2	-0.1	0.2	0.2	1.6
Severe depression (siblings)	1.0	1.1	4.3	-0.6	-1.2	-0.7	-0.4	2.1	-0.8	0.1
Pack years adult smoking proportion	1.1	1.7	3.8	1.5	0.9	0.2	1.9	-1.0	0.3	-2.0
Impedance of leg (right)	0.1	0.7	2.8	-0.6	-0.9	0.5	-1.7	-0.1	-0.8	0.4
Leg fat-free mass (left)	0.2	1.2	2.6	1.4	1.6	0.4	0.2	-1.2	0.4	-1.5
Trunk fat percentage	0.3	1.1	3.3	0.8	0.2	0.3	-1.2	-1.2	-0.8	-1.8
Hand grip strength (right)	0.4	1.2	3.2	0.6	0.5	0.3	-1.4	-1.8	-0.6	-1.3
Townsend deprivation index at recruitment	0.1	0.2	0.4	-0.5	0.3	0.1	0.3	-0.4	0.6	0.4
Current tobacco smoking	0.4	0.6	2.3	0.3	0.9	0.0	1.5	-0.8	0.4	-0.3
Average weekly fortified wine intake	1.0	1.2	2.6	-0.0	-1.5	-1.4	-0.1	-0.3	-1.6	-1.1
Maternal smoking around birth	0.1	0.1	0.4	-0.2	-0.4	0.0	0.2	-0.2	0.5	0.7
Fed-up feelings	0.4	0.8	3.8	0.4	-0.4	0.1	1.9	-0.3	1.0	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.8	-0.1	0.1	-0.5	0.3	-1.7	0.2	-0.3
Relative age voice broke	0.6	1.0	2.5	0.9	0.7	1.4	0.1	-0.5	0.9	-1.6
Taking other prescription medications	0.5	0.7	2.4	0.6	0.1	-1.3	-0.3	0.3	-0.3	-1.5
Age when periods started (menarche)	0.3	0.7	1.8	0.4	0.4	-1.3	-0.9	-1.2	-0.4	-0.6
Bilateral oophorectomy (both ovaries removed)	2.6	3.0	6.4	-1.3	-1.8	-2.5	-1.8	-0.6	-1.8	1.6
Heel bone mineral density (BMD) T-score, automated (left)	2.2	5.0	15.5	-2.6	-1.5	-2.1	-0.4	1.5	-1.7	3.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	-0.0	0.5	0.8	1.0	0.6	0.8	-0.1
Qualifications: CSEs or equivalent	0.2	0.3	1.4	0.5	1.2	-0.3	0.2	-0.4	0.2	-0.5
Serious illness, injury or assault to yourself	0.7	0.8	2.1	1.0	0.7	-0.9	0.1	-1.1	0.0	-1.4
High blood pressure	0.1	0.4	1.0	-0.3	-0.4	0.6	1.0	0.6	-0.5	-0.5
Hayfever, allergic rhinitis or eczema	0.2	0.4	2.0	0.4	0.8	-1.4	-0.1	-0.3	-0.1	-0.4
Multivitamins +/- minerals	1.3	1.6	4.8	0.8	0.7	1.3	0.9	2.2	0.2	-1.7
Stomach or abdominal pain in last month	2.3	2.9	4.5	-2.1	-2.1	-2.1	-1.4	0.5	-2.0	1.0
Supplements: Glucosamine	0.3	0.4	1.0	-0.7	-0.4	-0.6	-0.1	0.6	-0.4	1.0
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.9	0.6	0.9	-0.3	0.4	-1.7	0.4	-1.1
Medication: Atenolol	1.6	2.1	5.3	1.4	2.0	-0.6	0.7	-1.1	1.0	-2.3
Medication: Levothyroxine sodium	0.4	0.6	1.7	-0.4	-0.6	-1.0	-1.0	-0.3	-1.3	0.1
Sitting height	0.3	2.2	5.8	1.0	2.3	1.0	-1.3	-2.4	0.1	-0.9
Chronic bronchitis/emphysema (father)	4.1	4.8	10.5	-2.3	-2.1	-2.1	-2.4	0.4	-3.2	1.8
High blood pressure (mother)	2.3	3.3	9.7	1.3	1.6	3.1	2.3	0.0	0.6	-1.8
Body mass index (BMI)	0.3	1.1	2.4	1.1	1.0	0.1	1.6	-0.1	1.1	-1.2
Impedance of leg (left)	0.1	0.7	2.6	-0.5	-0.9	0.4	-1.6	-0.0	-0.9	0.0
Leg predicted mass (left)	0.2	1.2	2.5	1.4	1.6	0.5	0.2	-1.2	0.4	-1.5
Trunk fat mass	0.3	1.4	4.2	1.2	1.0	0.6	-0.7	-1.4	-0.1	-2.1
Waist circumference	0.5	1.8	5.8	1.6	1.1	0.7	1.2	-0.3	0.9	-2.4
Number of incorrect matches in round	0.7	1.1	4.9	-0.7	-1.3	0.2	0.4	2.2	0.5	0.3
Past tobacco smoking	0.2	0.3	1.0	-0.6	-0.2	0.1	0.1	0.3	-0.7	1.0
Alcohol usually taken with meals	0.6	1.0	3.8	-0.6	-0.2	-0.4	-1.1	2.0	-0.8	0.6
Nervous feelings	0.5	1.0	1.9	-1.2	-0.5	-1.2	-0.9	1.0	-1.4	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	3.4	-1.3	-1.8	-1.8	-1.1	1.3	-1.0	1.0
Hearing difficulty/problems with background noise	2.1	3.4	7.0	-1.5	-2.0	-1.8	-2.2	1.5	-2.6	-0.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.1	0.3	0.1	0.1
Had menopause	0.2	0.3	0.8	-0.3	-0.9	-0.8	-0.2	-0.0	-0.4	0.3
Had other major operations	0.3	0.4	1.2	-0.0	0.8	-0.6	-1.1	-0.8	0.2	-0.2
Forced vital capacity (FVC)	0.2	0.7	1.5	0.8	1.2	1.2	-0.1	-0.2	1.2	0.1
Heel bone mineral density (BMD) T-score, automated (right)	4.2	9.6	22.0	-3.5	-2.9	-2.6	-1.6	3.0	-2.4	4.7
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.6	-1.0	-1.9	-0.5	0.2	1.0	-1.2	0.7
Qualifications: None of the above	0.7	1.5	6.2	-0.5	0.8	1.2	-0.2	-2.5	1.2	0.5
Financial difficulties in last 2 years	0.6	0.9	1.5	1.0	1.2	1.2	0.6	0.0	1.2	-0.6
Mouth/teeth dental problems	1.6	2.5	6.4	-1.6	-1.4	-0.9	-0.9	2.5	-0.3	2.1
Heart attack	2.5	3.2	11.0	2.1	1.4	0.9	1.6	-1.2	0.3	-3.3
Allergy	0.3	0.6	1.9	-0.6	-0.4	1.1	0.5	0.5	0.4	1.4
Pain all over the body in last month	0.3	0.4	1.2	0.0	-1.1	-1.0	-0.5	0.3	-0.3	0.1
Diabetes (self-reported)	0.2	0.3	0.7	0.5	-0.8	-0.7	0.8	0.2	0.4	0.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.2	-0.4	-0.7	-1.1	-0.1	0.1	-1.1	-0.6
Medication: Ramipril	1.6	2.1	2.9	1.7	1.4	1.5	1.5	-1.6	1.3	-1.0
Medication: Simvastatin	0.2	0.2	0.9	-0.3	-0.2	-0.6	-1.0	-0.3	0.1	-0.3
Fluid intelligence score	0.6	1.2	3.8	1.2	2.0	1.2	0.6	-0.2	0.9	-0.8
Illnesses of siblings	0.4	0.5	1.8	0.4	0.9	-1.3	-0.5	0.1	0.4	0.6
Neuroticism score	0.4	0.7	1.6	-1.2	-1.2	-0.8	-0.6	0.2	-0.8	0.8
Weight	0.4	1.9	4.2	1.6	1.7	0.7	0.2	-1.4	0.9	-2.0
Impedance of arm (right)	0.4	1.8	7.0	-0.6	-1.2	0.5	-2.6	-0.6	-1.8	0.2
Arm fat percentage (right)	0.0	0.2	0.8	0.5	0.2	0.3	0.1	0.2	0.2	-0.9
Trunk fat-free mass	0.4	2.5	5.9	1.8	2.4	1.0	1.2	-0.8	2.0	-1.4
Hip circumference	1.0	4.4	7.0	2.6	2.6	1.6	1.1	-1.0	2.2	-2.7
Time employed in main current job	0.4	0.5	1.6	-0.4	-0.3	0.7	-0.2	-1.3	-1.0	-0.2
Alcohol intake versus 10 years previously	0.2	0.2	0.7	-0.2	-0.7	-0.1	0.1	-0.8	0.1	0.7
Father’s age at death	0.4	0.6	1.5	-0.8	1.0	1.2	-0.6	0.7	-0.1	0.5
Worrier / anxious feelings	0.5	1.0	2.2	-0.9	-1.5	-1.1	-0.8	0.5	-1.3	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.0	-1.3	-0.6	-0.8	-0.7	-1.3	-0.9	1.4
Falls in the last year	0.3	0.4	1.1	0.3	-1.1	-0.2	0.7	-0.7	0.2	-0.4
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	-0.6	-0.0	-0.4	-0.9	0.4	-0.9	0.4
Number of live births	0.3	0.4	1.0	-0.5	-0.9	0.8	-1.0	-0.4	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.9	1.2	1.6	1.2	0.2	-1.2	1.7	-0.1
Pulse rate	0.3	0.5	1.3	-0.8	-0.8	-0.6	-1.1	-0.0	-0.6	0.3
Happiness	0.4	0.4	1.5	0.5	1.1	0.1	0.2	0.2	-0.0	-1.2
Noisy workplace	0.9	1.1	3.0	-1.5	-1.4	-0.1	0.3	1.7	-0.4	0.4
Qualifications: A levels/AS levels or equivalent	0.7	1.5	6.3	1.4	2.5	0.2	0.5	0.6	0.7	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.2	1.0	0.5	1.1	1.2	-0.3	-0.3	-1.5
Mouth/teeth dental problems: Dentures	3.1	5.3	9.3	1.8	2.5	3.0	2.4	-1.8	2.2	-2.1
Asthma	1.6	3.2	6.4	2.1	1.8	0.4	1.5	-2.4	0.8	-2.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.4	0.2	-0.5	1.0	-0.9	1.8	-0.7	-0.9
Medication: Cholesterol lowering	0.3	0.5	1.7	0.6	0.0	-1.3	-0.1	-0.5	0.5	-0.8
Depression (self-reported)	1.7	2.0	3.5	-1.8	-1.1	-1.0	-1.9	1.6	-1.1	1.1
Medication: Lansoprazole	0.2	0.3	0.8	-0.3	-0.0	-0.2	-0.7	-0.3	-0.9	-0.6
Prospective memory result	1.4	1.7	5.7	-1.0	-1.7	-1.0	-0.2	2.4	0.1	1.0
Lung cancer (father)	1.0	1.1	2.7	-1.6	-0.7	-0.4	-1.4	0.3	-0.1	1.6
Illnesses of mother	2.0	2.4	6.1	-1.8	-1.2	-1.1	-2.5	0.3	-1.6	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	4.3	1.5	1.9	1.7	0.8	-0.6	2.1	-0.5
Pulse wave Arterial Stiffness index	0.3	0.3	0.8	0.3	0.6	-0.7	0.5	-0.1	0.9	0.4
Impedance of arm (left)	0.6	2.7	10.1	-0.9	-1.2	0.5	-3.2	-1.0	-2.3	0.3
Arm fat mass (right)	0.2	0.7	2.2	1.0	1.0	0.4	0.4	-0.5	0.5	-1.5
Trunk predicted mass	0.5	2.6	6.1	1.8	2.5	1.0	1.2	-0.8	2.0	-1.4
Standing height	0.4	3.7	8.4	1.2	1.9	1.3	-2.7	-2.9	-0.3	-1.7
Length of working week for main job	0.3	0.3	0.7	0.7	0.4	0.7	0.1	0.8	0.7	-0.1
Exposure to tobacco smoke at home	0.3	0.3	1.1	-0.6	-0.6	1.0	-0.6	-0.2	0.5	0.0
Breastfed as a baby	0.6	0.7	1.5	0.7	0.1	-0.7	1.0	1.2	0.5	-1.2
Tense / ‘highly strung’	0.4	0.7	4.5	0.1	0.4	-2.1	-0.1	-0.2	0.3	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.9	-1.4	-2.0	-0.4	-0.5	1.5	-0.9	0.7
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	0.3	0.1	-0.3	0.7	-0.3	0.5	-0.6
Birth weight of first child	1.6	2.9	11.1	-1.4	-0.7	-0.8	-3.3	-0.8	-1.6	1.7
Peak expiratory flow (PEF)	0.7	1.7	4.0	1.2	1.9	0.5	0.9	-1.2	2.0	0.3
Pulse wave reflection index	0.1	0.2	0.4	0.0	-0.3	-0.2	0.6	0.6	0.5	0.4
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.7	-0.3	-0.3	-0.3	-0.8	-0.0	-0.8	-0.5
Loud music exposure frequency	0.6	0.6	1.4	-0.4	0.7	0.3	0.6	1.1	0.7	1.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.8	0.0	0.2	1.2	0.4	1.4	-0.1	0.2
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.1	1.5	1.0	0.0	0.7	-2.0	0.1	-1.9
Blood clot in the leg (DVT)	0.4	0.5	0.9	0.1	-0.9	-0.9	-0.2	-0.9	-0.0	-0.9
Medication: Paracetamol	0.3	0.5	1.4	-0.2	-0.8	1.2	0.4	1.1	-0.5	0.3
Headache pain in last month	2.8	4.8	12.1	-2.5	-2.4	-1.2	-2.0	1.0	-3.5	1.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	-0.6	0.0	0.5	-0.5	0.1	-0.4	0.9
Glaucoma (self-reported)	0.8	1.0	2.1	0.9	1.5	-1.1	0.4	-1.3	1.0	-0.1
Gout (self-reported)	0.6	0.9	4.4	-0.1	-0.4	-2.1	0.0	1.1	-0.4	0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.0	0.3	0.1	-0.7	-0.7	-1.0	-0.5	-0.2
Medication: Amlodipine	0.6	0.8	2.2	1.0	0.7	-0.6	0.6	-1.0	-0.6	-1.5
Medication: Ventolin 100micrograms inhaler	0.6	0.7	3.7	0.4	0.5	0.9	1.9	0.1	0.5	-0.2
Birth weight	0.8	1.8	5.2	-0.9	-0.2	-0.6	-2.3	-1.9	-1.4	-0.9
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.8	-0.0	0.6	-0.2	-0.2	-1.3	1.1	1.3
High blood pressure (siblings)	0.7	1.0	4.6	0.3	-0.3	2.2	1.0	0.5	0.3	-0.8
Forced vital capacity (FVC), Best measure	0.3	1.2	2.7	1.0	1.3	1.6	0.6	-0.0	1.6	-0.0
Body fat percentage	0.2	0.6	2.9	0.7	0.3	0.1	-0.6	-0.7	-0.3	-1.7
Leg fat percentage (right)	0.2	0.7	2.2	1.1	0.6	-0.0	0.5	-0.4	0.7	-1.5
Arm fat-free mass (right)	0.3	1.6	4.3	1.4	2.1	0.9	0.5	-1.0	1.1	-1.3
Exposure to tobacco smoke outside home	0.8	1.1	3.5	-0.7	-1.4	-1.1	-0.7	0.4	-1.9	-0.1
Comparative body size at age 10	0.2	0.7	2.0	-0.6	-0.1	0.2	0.5	1.4	0.6	1.3
Number of full brothers	0.2	0.2	0.6	-0.6	-0.8	0.4	-0.4	-0.4	-0.0	-0.1
Worry too long after embarrassment	0.9	1.5	4.3	-1.4	-0.9	-0.9	-2.1	0.0	-0.8	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.4	7.8	-2.0	-2.0	-1.3	-1.4	2.8	-1.1	1.8
Wheeze or whistling in the chest in last year	0.6	1.1	3.5	-1.3	-1.9	-0.5	-0.6	0.9	-0.9	0.8
Number of children fathered	1.0	1.1	4.4	-1.2	-2.1	0.1	-0.2	-0.3	-1.1	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.1	0.5	0.4	1.4	0.6	0.4	1.1	-0.1
Age at first live birth	1.1	2.0	5.3	1.6	2.3	0.4	1.5	-0.8	1.5	-0.8
Pulse wave peak to peak time	0.2	0.3	0.9	0.0	-0.2	0.9	-0.4	-0.1	-0.6	-0.8
Health satisfaction	0.4	0.5	2.4	-0.8	-0.1	0.8	-0.3	-0.2	-1.5	-0.1
Shortness of breath walking on level ground	0.3	0.4	0.8	-0.9	-0.5	0.7	-0.3	0.8	-0.2	0.7
Qualifications: College or University degree	0.2	0.5	1.8	-0.1	-0.3	-1.3	-0.2	1.2	-0.3	0.6
Eye problems/disorders: None of the above	0.3	0.4	0.7	0.5	-0.7	0.7	0.5	-0.8	-0.7	-0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.0	0.1	0.6	0.5	0.4	-1.0	-0.4	-0.5
Emphysema/chronic bronchitis	1.0	1.1	2.0	-1.3	-1.2	-0.1	-1.2	-0.4	-1.1	1.4
Medication for pain relief, constipation, heartburn	0.5	0.9	4.1	-0.8	0.3	-0.3	-0.8	-2.0	-0.2	0.7
Neck or shoulder pain in last month	0.9	1.3	2.2	-1.5	-1.3	-0.1	-0.3	1.3	-1.4	1.3
Medication: Blood pressure	0.1	0.1	0.2	0.1	-0.5	-0.5	0.4	0.2	-0.1	-0.2
Angina (self-reported)	1.1	1.5	4.0	1.2	0.6	-2.0	0.4	-1.2	0.1	-1.7
Migraine (self-reported)	0.8	1.0	2.2	0.9	0.5	1.2	0.9	1.5	0.5	-1.2
Medication: Ibuprofen	0.9	1.1	3.5	0.7	-0.1	1.6	0.2	1.9	0.1	-1.0
Medication: Allopurinol	0.3	0.3	0.9	0.5	0.5	-1.0	0.4	0.8	0.4	-0.1
Medication: Omeprazole	0.4	0.5	1.5	-0.4	-1.2	-0.6	-0.0	0.8	-0.8	-0.5
Medication: Seretide 50 evohaler	0.2	0.2	0.6	-0.6	0.2	0.2	-0.1	0.6	0.2	0.8
Mean time to correctly identify matches	0.3	0.5	1.8	-0.2	-0.6	0.8	0.7	1.3	0.3	-0.5
Heart disease (mother)	1.9	2.4	4.5	2.0	0.9	1.4	2.1	-0.1	1.5	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.0	1.0	1.4	0.1	0.1	-0.8	1.1	-0.2
Whole body fat mass	0.2	1.0	3.5	1.0	1.0	0.3	-0.4	-1.0	0.2	-1.9
Leg fat mass (right)	0.2	0.7	2.2	1.0	0.9	0.1	0.3	-0.5	0.5	-1.5
Arm predicted mass (right)	0.4	2.3	5.7	1.7	2.4	1.0	0.8	-1.2	1.4	-1.5
Pulse rate, automated reading	0.4	1.3	3.0	-1.7	-1.2	0.2	-0.9	1.0	-0.3	1.6
Alcohol intake frequency.	0.1	0.3	1.5	-0.1	0.2	0.2	0.4	-1.2	0.0	-0.5
Comparative height size at age 10	0.2	1.3	4.7	-0.6	0.0	0.3	-2.2	-1.8	-0.9	0.1
Number of full sisters	0.2	0.2	0.7	0.2	0.2	0.1	-0.8	-0.3	0.4	0.5
Suffer from ‘nerves’	1.1	1.7	4.0	-1.5	-0.9	-2.0	-1.3	0.4	-1.3	0.9
Overall health rating	0.1	0.2	0.4	-0.6	-0.0	0.5	0.4	-0.1	-0.3	0.5
Chest pain or discomfort	2.5	3.7	6.2	-2.3	-2.5	-2.0	-1.4	-0.4	-2.3	1.6
Had major operations	0.4	0.5	0.8	-0.6	-0.2	-0.5	-0.8	0.6	-0.8	0.9
Age at last live birth	0.7	1.1	3.7	1.0	1.9	0.4	1.2	-0.2	1.0	-0.3
Family relationship satisfaction	0.7	0.9	2.6	0.7	1.6	-0.3	0.7	-0.5	1.4	-0.2
Leg pain on walking	2.8	3.5	6.8	-2.6	-2.4	-0.7	-1.6	0.8	-1.2	2.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.9	-0.5	-1.2	-1.3	-0.3	0.3	-1.4	-0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.1	0.6	0.3	-1.0	0.6	-0.9	0.3	0.8
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	5.8	-1.8	-0.5	-0.3	-1.2	0.4	-0.8	2.4
Medication: Aspirin	0.5	0.6	2.2	0.7	0.5	-1.5	0.9	0.5	0.7	-0.2
Supplements: Vitamin C	0.3	0.3	1.0	-0.6	-0.6	-0.2	-0.1	1.0	-0.4	0.6
Knee pain experienced in last month	0.3	0.5	1.5	-0.4	-0.5	-1.2	0.1	0.8	-0.7	0.5
Hypertension (Self-reported)	0.1	0.4	0.7	-0.7	-0.8	0.1	0.6	0.7	-0.8	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.0	-0.1	-0.3	-1.0	-0.1	0.2	-0.8	-0.5
Illnesses of father: Heart disease	0.4	0.6	1.4	1.0	0.4	-0.3	1.2	0.5	0.2	-1.1
Illnesses of siblings: Diabetes	0.2	0.2	0.6	0.5	0.3	0.6	-0.3	-0.8	0.2	-0.6
Smoking status: Previous	0.2	0.3	1.1	0.3	-0.4	0.5	-0.5	-0.1	0.3	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.2	6.1	2.0	2.5	2.4	0.2	-1.3	0.9	-2.0
Whole body fat-free mass	0.3	1.8	4.0	1.6	2.0	0.7	0.7	-0.9	1.2	-1.5
Leg fat-free mass (right)	0.2	1.2	2.5	1.4	1.6	0.3	0.2	-1.1	0.3	-1.6
Arm fat percentage (left)	0.1	0.4	1.7	0.7	0.6	0.5	0.1	-0.2	0.2	-1.3
Average weekly red wine intake	0.2	0.3	1.3	-0.1	0.6	-0.7	0.3	1.1	0.4	0.1
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.2	-1.7	-1.2	-1.2	-1.2	1.8	-0.6	1.3
Mood swings	0.4	0.7	2.2	-0.5	-1.5	0.3	0.7	1.2	-0.7	-0.2
Loneliness, isolation	0.8	1.1	2.0	-1.4	-1.3	-0.8	-0.3	-0.8	-1.4	0.9
Long-standing illness, disability or infirmity	1.0	1.5	4.0	1.4	1.1	0.1	1.3	-0.8	0.9	-2.0
Ever had bowel cancer screening	3.0	3.5	5.5	-2.1	-2.1	-2.3	-1.1	0.7	-1.7	2.3
Diabetes diagnosed by doctor	0.2	0.4	1.1	-0.2	-1.0	-0.7	0.4	0.2	0.3	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.8	0.2	0.2	1.3	1.1	0.9	0.3	0.3
Friendships satisfaction	1.3	1.6	3.2	1.0	1.8	0.9	1.7	-0.5	1.6	-0.9
Qualifications: nursing, teaching	0.7	1.1	3.4	1.0	1.8	-0.6	1.1	0.3	1.3	-0.6
Commuting to job workplace: Walk	1.3	1.4	7.3	-0.6	0.4	2.7	-0.7	0.7	-0.5	-0.6
Eye problems/disorders: Cataract	0.3	0.3	0.9	0.4	1.0	0.2	-0.3	0.1	1.0	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.6	0.2	-0.0	-0.0	-0.6	0.1	-0.7
Medication for cholesterol	0.2	0.2	0.8	0.1	-0.4	-0.1	0.5	-0.2	0.6	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.9	-0.1	-0.6	-0.5	0.9	0.9	0.3	0.3
Back pain experienced in last month	0.3	0.4	1.7	0.3	0.1	-1.3	0.1	-0.6	-0.3	-0.8
Mineral and other dietary supplements	0.9	1.2	2.2	1.5	0.8	0.3	1.0	-1.1	1.5	-1.1
Breast cancer (self-reported)	3.7	4.4	8.2	-2.8	-1.4	-1.8	-2.6	0.9	-1.4	2.9
Asthma (self-reported)	1.4	2.9	6.0	2.0	1.7	0.3	1.5	-2.1	0.5	-2.4
Osteoporosis (self-reported)	0.9	1.1	3.7	0.9	0.5	1.2	1.0	-0.7	-0.5	-1.9
Osteoarthritis (self-reported)	0.3	0.4	1.7	-0.8	-0.0	-0.7	-0.4	0.1	0.2	1.3
Medication: Aspirin	0.5	0.6	2.3	0.7	0.4	-1.5	0.9	0.4	0.7	-0.3
Medication: Gliclazide	1.0	1.1	3.1	0.1	-0.2	0.2	1.8	0.9	1.7	1.0
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.3	-0.1	0.1	-0.4	-0.0	0.3	0.4
Smoking status: Current	0.4	0.7	2.5	0.5	0.9	-0.1	1.6	-0.7	0.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	2.5	0.1	0.3	-0.0	0.3	-0.2	0.9	1.6
Whole body water mass	0.3	1.7	4.1	1.6	2.0	0.6	0.7	-0.9	1.2	-1.4
Leg predicted mass (right)	0.2	1.3	2.8	1.5	1.6	0.3	0.2	-1.1	0.3	-1.7
Arm fat mass (left)	0.3	1.1	2.8	1.3	1.2	0.5	0.6	-0.9	0.7	-1.7
Number of self-reported non-cancer illnesses	0.3	0.5	1.1	0.3	1.0	-0.3	0.1	1.1	0.5	-0.7
Average weekly champagne plus white wine intake	0.8	1.1	2.6	1.6	0.5	0.9	1.5	0.0	0.6	-1.1
Miserableness	0.2	0.3	0.9	-0.3	-0.3	-0.3	0.7	0.4	0.6	0.9
Guilty feelings	1.2	1.8	3.3	-1.8	-1.1	0.0	-1.5	0.3	-1.7	1.6
Wears glasses or contact lenses	0.2	0.3	0.8	0.1	0.2	-0.6	0.3	-0.8	0.9	-0.0
Ever taken oral contraceptive pill	0.5	0.6	2.2	0.9	-0.5	-0.7	-0.0	-0.3	-0.2	-1.5
Hearing aid user	0.7	0.8	1.7	-0.6	-1.2	-1.2	-1.3	0.7	-0.2	0.4
Mother’s age at death	0.5	0.7	3.0	0.5	-0.2	1.0	1.7	0.4	0.3	-0.3
Financial situation satisfaction	0.4	0.5	1.7	0.1	0.3	1.3	0.7	0.7	0.4	-0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.7	-0.3	-0.5	0.1	0.8	0.9	1.3	1.1
Commuting to job workplace: Public transport	0.4	0.5	1.5	0.3	0.8	0.6	0.5	1.2	0.6	-0.6
Eye problems/disorders: Glaucoma	1.2	1.4	3.2	1.2	1.8	-0.6	0.9	-0.9	1.8	-0.2
Medication: Blood pressure	0.5	0.9	4.0	0.5	0.9	0.9	0.2	-0.2	-0.5	-2.0
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	-0.3	0.5	-0.3	0.2	-0.4	-0.4	0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.5	-0.7	0.7	0.1	-0.0	0.5	-0.5	0.5
High cholesterol (Self-reported)	1.0	1.8	3.9	-2.0	-1.7	-0.3	-1.3	1.1	-0.5	1.6
Medication: Bendroflumethiazide	2.0	3.0	9.0	1.3	0.9	2.2	1.4	1.5	0.8	-3.0
Medication: Paracetamol	0.6	0.9	3.5	0.5	-0.5	1.9	1.2	0.9	0.2	-0.2
Medication: Lisinopril	0.6	0.8	1.5	-1.2	-0.7	0.3	-1.2	-0.6	-1.1	0.9
Medication: Atorvastatin	0.3	0.4	1.0	1.0	0.4	-0.4	0.4	0.6	0.6	-0.5
Illnesses of father: High blood pressure	1.1	1.3	3.4	1.2	0.6	1.6	1.9	0.1	1.3	-0.1
Alcohol drinker status: Never	0.1	0.1	0.6	0.2	-0.0	0.2	0.8	0.1	-0.0	0.1
Ever smoked	0.1	0.2	0.8	-0.4	-0.0	-0.8	-0.9	-0.2	-0.2	-0.2
Basal metabolic rate	0.3	1.8	3.8	1.7	1.9	0.7	0.6	-1.0	1.1	-1.7
Leg fat percentage (left)	0.2	0.7	2.9	1.0	0.6	-0.2	0.4	-0.5	0.6	-1.7
Arm fat-free mass (left)	0.3	1.7	3.6	1.6	1.9	0.6	0.8	-1.0	1.3	-1.4
Number of operations (self-reported)	1.2	1.8	6.2	-0.9	-0.1	-2.5	-1.4	0.8	-1.6	0.7
Average weekly beer plus cider intake	0.3	0.5	1.9	-0.0	-0.9	0.7	-0.1	1.4	0.1	-0.3
Irritability	0.1	0.2	0.4	-0.5	-0.4	0.6	-0.0	-0.1	-0.4	0.4
Risk taking	0.9	1.3	3.7	-0.9	-1.9	0.3	-0.9	1.3	-1.3	0.3
Ever had prostate specific antigen (PSA) test	4.0	4.6	10.2	-2.6	-2.4	-1.9	-2.0	0.7	-1.4	3.2
Fractured/broken bones in last 5 years	1.5	1.9	7.8	0.9	0.4	2.8	0.7	1.2	1.1	-1.1
Age started oral contraceptive pill	2.0	2.5	5.2	-1.4	-1.7	-2.3	-1.7	-0.1	-1.5	1.4
Diastolic blood pressure, automated reading	0.1	0.5	2.2	-0.4	-0.6	-0.5	0.5	1.5	-0.1	0.1
Ever depressed for a whole week	0.2	0.3	1.0	-0.5	-0.8	0.0	0.1	-0.4	-1.0	-0.1
Unable to work because of sickness or disability	0.5	0.6	2.5	-0.7	0.5	-0.6	-0.7	-1.6	-0.3	-0.0
Commuting to job workplace: Cycle	0.3	0.3	1.2	-0.5	-1.1	0.3	-0.0	0.7	0.1	0.3
Myopia	1.1	1.6	3.2	-1.1	-1.8	-1.1	-0.4	1.6	-1.2	1.2
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.1	-0.3	0.0	-0.3	-1.4	-0.2	0.1	1.2
Cholesterol lowering medication	0.7	1.1	3.4	-1.1	-1.0	-0.1	-1.8	0.1	-1.4	0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.2	0.3	-0.5	-0.1	0.6	0.6	-0.2	-1.1
Pain experienced in last month	0.1	0.2	0.5	-0.0	0.1	0.3	-0.7	-0.6	0.4	-0.1
Supplements: Calcium	0.1	0.1	0.3	-0.3	0.3	-0.4	-0.1	0.6	0.0	0.5
Basal cell carcinoma (self-reported)	0.3	0.4	1.1	0.2	-0.5	-1.0	0.1	1.0	0.4	0.3
Heart attack/myocardial infarction (self-reported)	2.3	2.9	9.9	2.0	1.4	0.8	1.7	-1.0	0.3	-3.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.7	-0.1	-1.3	-0.9	-0.2	-0.7	-0.2	-0.8
Heart disease (siblings)	0.2	0.2	0.7	0.2	-0.6	0.2	0.7	-0.3	-0.1	-0.8
Alcohol drinker status: Previous	1.3	1.5	3.4	-1.6	-1.2	-0.6	-1.4	1.0	-1.8	0.1
Pack years of smoking	1.2	1.8	4.5	1.4	0.9	0.1	2.1	-1.1	0.6	-1.9
Impedance of whole body	0.4	2.0	7.4	-0.6	-1.1	0.5	-2.7	-1.1	-1.9	-0.1
Leg fat mass (left)	0.2	0.9	3.0	1.1	1.1	-0.1	0.3	-0.7	0.6	-1.7
Arm predicted mass (left)	0.4	1.9	3.8	1.6	1.9	0.6	0.9	-1.1	1.4	-1.6