Hub : Genes

GGA1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.156	0.0510	0.00035	0.061	NA	0.029	NA	0.017	2.4e-05	NA	0.00290	NA	0.0170
2	GTEx	Vagina	0.441	0.1570	0.00840	0.008	NA	0.166	NA	0.101	2.1e-01	NA	0.00013	NA	0.0027
3	TCGA	Lung Adenocarcinoma	0.044	0.0233	0.00110	0.022	0.031	0.028	NA	0.022	1.1e-03	0.00012	0.00026	NA	0.0012
4	TCGA	Thyroid Carcinoma	0.038	0.0190	0.00200	0.014	0.025	0.018	NA	0.014	1.3e-02	0.00170	0.00610	NA	0.0140

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	1.0	1.6	-0.8	0.3	1.2	1.3
Bipolar Disorder or Schizophrenia	0.3	0.6	1.2	0.6	0.1	1.0	1.1
Depressed Affect (Nagel 2018)	0.3	0.6	2.1	-1.4	0.5	0.3	-0.1
Depression (Nagel 2018)	0.2	0.2	0.4	0.6	-0.4	0.1	-0.6
Intelligence (Savage-Jansen 2018)	1.6	5.0	8.2	2.2	-0.0	-2.9	-2.6
Neuroticism (Nagel 2018)	0.3	0.6	1.4	-1.2	0.1	-0.4	-0.9
Schizophrenia (2018)	0.2	0.5	1.7	1.3	-0.2	0.3	0.4
Schizophrenia vs Biploar Disorder	1.0	1.4	3.7	1.9	1.3	0.2	-0.4
Worry (Nagel 2018)	0.7	1.4	2.5	-0.7	-0.1	-1.6	-1.6
Alzheimer’s Disease (in mother)	2.0	2.3	4.6	2.2	1.9	0.9	0.5
Alzheimer’s Disease (in father)	0.2	0.2	0.8	0.3	-0.1	-0.9	0.2
Alzheimer’s Disease (including proxy)	0.8	1.2	2.2	1.5	0.9	0.8	1.0
Crohns Disease (2017)	0.3	0.6	0.9	0.5	0.9	0.9	-0.6
Irritable Bowel Disease (IBD)	0.2	0.6	1.7	-0.7	1.3	-0.1	-0.4
Ulcerative Colitis (UC)	0.4	0.7	1.6	-0.9	1.3	-0.6	0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.5	2.9	5.8	1.4	-0.3	-2.0	-2.4
Verbal and Numeric Reasoning (VNR)	1.6	3.7	5.3	2.0	-0.9	-2.3	-2.2
Breast Cancer	1.5	3.6	6.2	-1.5	-2.5	1.3	2.0
Ovarian Cancer	1.4	1.9	4.5	2.1	-1.4	0.4	1.0
Prostate Cancer	0.7	1.0	2.6	-0.4	-0.2	-1.6	-1.1
Age at First Birth	1.5	2.1	8.0	2.8	0.3	0.6	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	-0.8	0.3	0.6	0.2
Coronary Artery Disease (CAD)	1.3	1.6	4.8	-0.4	2.2	-0.9	-0.9
Crohns Disease (2012)	0.8	1.2	2.8	0.8	1.7	-0.5	-1.1
Mean Putamen Volume	1.3	1.5	3.4	-1.8	-0.9	1.2	0.7
Fasting Glucose	0.1	0.1	0.4	0.2	-0.0	-0.6	-0.2
HbA1C	1.1	1.2	3.5	0.4	-1.9	-0.9	-0.6
HDL Cholesterol	0.2	0.4	0.7	0.8	0.4	0.6	0.5
LDL Cholesterol	0.7	1.1	1.8	1.1	1.3	-0.5	-1.1
Lupus	1.4	2.1	4.6	-1.7	2.1	0.9	0.3
Neuroticism (2016)	0.6	0.9	1.5	-1.1	-0.8	-0.5	-1.2
Primary Biliary Cirrhosis	0.3	0.4	1.3	-0.4	0.2	-0.4	-1.1
Rheumatoid Arthritis	1.0	1.4	3.4	-0.4	-0.0	-1.8	-1.4
Schizophrenia (2014)	0.3	0.6	1.9	1.4	-0.3	0.2	0.7
Triglycerides	0.2	0.3	0.6	-0.6	-0.4	-0.0	0.8
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.9	1.1	1.7	-0.3	-0.6
Ulcerative Colitis	0.3	0.5	1.5	-0.1	0.0	-1.2	0.6
Blood Eosinophil Count	0.4	3.2	4.2	1.8	-1.5	2.0	1.7
Blood Platelet Count	0.6	7.5	13.4	-3.7	-2.7	2.4	1.8
Blood Red Count	0.4	3.8	8.2	-1.4	0.7	2.1	2.9
Blood White Count	0.4	3.0	6.4	-0.5	0.0	2.3	2.5
Heel T-Score	1.5	12.2	20.0	-3.4	-1.0	4.0	4.5
BMI	2.6	15.0	34.4	-0.1	-0.1	5.1	5.9
Height	0.8	15.5	31.0	3.5	-0.5	-5.6	-4.3
Waist Hip Ratio (WHR)	0.3	1.3	3.0	-1.7	-1.1	-0.3	-0.8
Systolic Blood Pressure	0.4	1.8	5.0	-2.2	-1.0	0.9	0.7
Smoking Status	0.2	0.4	0.8	0.5	0.4	-0.6	-0.9
Allergy or Eczema	0.0	0.0	0.1	0.1	-0.3	0.1	0.1
Cardiovascular Disease	0.1	0.3	0.6	-0.3	0.2	0.7	0.6
Hypothyroidism (self reported)	0.2	0.5	0.9	-0.5	0.3	1.0	0.8
Respiratory disease	0.6	1.4	3.1	-0.1	-0.8	-1.4	-1.8
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.7	-1.3	-0.7	-0.9	-0.6
Lung FEV1/FVC ratio	0.4	2.3	6.0	-0.3	0.0	2.5	1.7
Lung FVC	0.2	1.1	2.6	0.8	0.4	-1.0	-1.6
Neuroticism	0.2	0.5	1.7	-1.3	0.3	0.3	-0.1
Chronotype (morning person)	0.5	1.3	3.2	0.9	1.8	-0.6	-0.9
Hair Pigment	0.0	0.1	0.2	0.4	-0.0	-0.3	-0.2
Tanning	0.4	5.5	7.0	2.6	1.9	-2.2	-2.5
Hand grip strength (left)	0.2	0.6	2.1	0.3	0.0	0.6	1.5
Number of treatments/medications taken	0.9	1.7	3.6	1.9	1.7	0.0	-0.4
Average weekly spirits intake	0.3	0.3	0.5	0.6	0.5	0.4	0.7
Sensitivity / hurt feelings	0.7	1.2	3.5	-1.9	-0.3	-0.5	-1.0
Frequency of depressed mood in last 2 weeks	0.9	1.3	4.6	-0.1	0.2	-0.8	-2.1
Hearing difficulty/problems: Yes	0.8	1.2	2.2	-1.5	-1.4	-0.7	-0.0
Relative age of first facial hair	0.5	1.1	3.0	1.7	-0.1	-0.5	1.0
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	0.3	-0.2	-0.1	-0.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.2	1.1	0.0	1.1	0.9
Ever had hysterectomy (womb removed)	0.4	0.5	0.8	-0.8	-0.4	-0.9	-0.5
Systolic blood pressure, automated reading	0.2	0.6	2.2	-1.5	-0.6	0.1	-0.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.2	0.1	-0.6	0.9	1.1
Angina	1.7	2.2	3.6	1.6	1.0	-1.3	-1.9
Medication for hormone replacement therapy	0.5	0.6	1.5	-0.8	-1.2	0.2	0.2
Vitamin and mineral supplements	0.5	0.6	1.9	-1.4	0.0	-0.3	-0.7
Supplements: Zinc	2.0	2.2	7.3	-1.2	-2.7	-0.1	0.0
Medication: Co-codamol	0.0	0.1	0.2	-0.0	-0.4	-0.1	0.1
Medication: Metformin	0.4	0.6	1.2	-0.8	0.3	-1.1	-0.6
Diabetes (father)	0.8	1.0	2.9	-1.7	-0.4	-0.9	-0.1
Diabetes (mother)	2.5	3.2	7.1	-2.7	-2.0	0.7	1.2
Severe depression (siblings)	0.2	0.2	0.8	-0.9	-0.2	-0.1	-0.3
Pack years adult smoking proportion	1.2	1.8	5.1	0.3	-1.0	0.9	2.2
Impedance of leg (right)	0.1	0.5	1.0	-0.5	-0.1	-1.0	-0.9
Leg fat-free mass (left)	0.2	1.1	3.1	0.2	-0.5	1.0	1.8
Trunk fat percentage	1.6	6.2	15.6	-1.1	0.8	2.7	4.0
Hand grip strength (right)	0.1	0.2	0.3	0.2	-0.5	-0.5	0.4
Townsend deprivation index at recruitment	0.3	0.5	0.8	-0.3	0.5	0.9	0.9
Current tobacco smoking	0.5	0.9	1.4	0.7	-0.5	-1.2	-1.1
Average weekly fortified wine intake	0.9	1.1	1.5	1.1	0.0	-1.2	-1.2
Maternal smoking around birth	0.6	0.8	1.6	1.1	-1.3	0.4	-0.6
Fed-up feelings	0.4	0.8	2.5	-1.6	0.3	0.5	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.4	0.6	-0.7	1.2	0.9
Relative age voice broke	0.2	0.4	1.2	-0.3	0.0	0.4	1.1
Taking other prescription medications	0.2	0.2	0.6	0.8	0.4	-0.4	-0.3
Age when periods started (menarche)	0.2	0.4	1.3	0.0	-0.3	-0.5	-1.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.4	-0.2	0.1	-0.9	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	5.2	-1.6	0.1	1.6	2.3
Tinnitus: Yes, but not now, but have in the past	1.8	2.0	4.7	2.2	1.5	0.6	0.8
Qualifications: CSEs or equivalent	0.4	0.5	0.8	0.8	0.9	-0.3	-0.7
Serious illness, injury or assault to yourself	0.1	0.2	0.4	-0.0	0.0	0.6	0.6
High blood pressure	0.0	0.1	0.3	0.1	-0.2	-0.6	-0.3
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.2	0.0	-1.8	0.1	0.4
Multivitamins +/- minerals	0.5	0.7	2.5	1.6	0.4	0.1	0.2
Stomach or abdominal pain in last month	0.5	0.6	1.6	-0.7	-1.3	0.6	0.3
Supplements: Glucosamine	1.0	1.3	3.4	1.8	0.5	-0.7	-1.0
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.8	-0.9	-0.2	-0.2	-0.5
Medication: Atenolol	3.2	4.0	9.9	3.1	2.4	0.2	-0.2
Medication: Levothyroxine sodium	0.1	0.2	0.6	-0.2	0.7	0.4	0.5
Sitting height	0.6	4.4	8.6	1.0	-1.2	-2.9	-2.5
Chronic bronchitis/emphysema (father)	0.3	0.4	1.1	0.1	1.1	-0.7	-0.2
High blood pressure (mother)	0.3	0.4	0.9	-0.4	-0.9	-0.3	0.6
Body mass index (BMI)	1.4	6.1	14.3	-0.5	0.5	3.1	3.8
Impedance of leg (left)	0.2	0.9	1.7	-0.6	0.2	-1.2	-1.3
Leg predicted mass (left)	0.2	1.0	3.0	0.2	-0.5	0.9	1.7
Trunk fat mass	1.0	4.5	11.9	-1.0	0.2	2.3	3.4
Waist circumference	0.7	2.7	6.8	-0.5	-0.3	1.9	2.6
Number of incorrect matches in round	1.0	1.6	2.6	-1.0	0.8	1.4	1.6
Past tobacco smoking	0.7	1.4	4.6	-0.8	-2.1	-0.3	0.4
Alcohol usually taken with meals	0.8	1.3	2.1	1.4	-1.4	0.8	0.6
Nervous feelings	0.6	1.0	2.2	-0.6	-0.7	-1.5	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.1	-0.1	0.4	1.0	0.3
Hearing difficulty/problems with background noise	1.0	1.6	5.0	-2.2	-1.1	-0.2	0.5
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	0.6	0.2	0.5	0.8
Had menopause	2.3	2.9	5.9	2.4	1.1	1.3	1.7
Had other major operations	1.3	1.6	3.0	1.2	0.6	1.7	1.2
Forced vital capacity (FVC)	0.3	1.3	2.7	0.1	-1.1	-1.6	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.2	-1.6	-0.2	1.6	2.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.6	-1.3	-0.8	0.5	1.0
Qualifications: None of the above	0.4	1.0	2.7	-1.0	1.6	0.1	-0.3
Financial difficulties in last 2 years	0.3	0.4	1.4	-0.0	-1.2	-0.0	-0.3
Mouth/teeth dental problems	0.5	0.8	1.5	-1.0	0.2	-1.2	-0.8
Heart attack	1.2	1.5	5.3	-0.2	2.3	-0.0	-0.8
Allergy	0.2	0.4	1.2	-0.2	1.1	-0.3	-0.4
Pain all over the body in last month	0.6	0.6	1.7	-1.3	-0.9	0.1	-0.2
Diabetes (self-reported)	0.3	0.4	1.1	-1.1	0.5	-0.5	-0.4
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	2.3	-0.3	-0.4	-1.5	-1.4
Medication: Ramipril	1.6	2.1	4.2	1.4	0.1	-2.0	-1.4
Medication: Simvastatin	0.5	0.8	1.8	0.2	-0.4	-1.3	-1.0
Fluid intelligence score	1.7	3.4	4.8	1.9	-1.6	-2.2	-1.7
Illnesses of siblings	0.5	0.8	2.0	1.4	0.7	0.4	-0.6
Neuroticism score	0.4	0.9	2.8	-1.7	0.2	-0.4	-0.8
Weight	0.4	2.1	6.1	0.1	-0.4	1.5	2.5
Impedance of arm (right)	0.1	0.5	1.0	-0.7	-0.7	-1.0	-0.5
Arm fat percentage (right)	1.7	6.7	16.0	-1.1	-0.1	3.1	4.0
Trunk fat-free mass	0.1	0.8	1.4	1.2	-1.1	-0.6	-0.4
Hip circumference	0.5	2.0	5.2	0.6	0.1	1.5	2.3
Time employed in main current job	0.2	0.2	0.5	-0.4	0.1	0.5	0.7
Alcohol intake versus 10 years previously	0.5	0.7	1.5	-1.2	-0.6	-0.1	0.9
Father’s age at death	0.2	0.3	0.7	0.8	0.5	-0.0	0.2
Worrier / anxious feelings	1.2	2.2	3.5	-1.7	-0.3	-1.6	-1.9
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.5	6.4	-1.1	0.4	2.5	2.5
Falls in the last year	0.6	0.9	1.6	-1.3	-0.9	0.3	1.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.3	0.7	0.2	-0.2
Number of live births	0.2	0.3	1.1	0.2	0.4	1.0	0.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.0	-0.5	-1.0	-0.9	-0.6
Pulse rate	0.3	0.4	0.8	0.1	0.9	0.8	0.5
Happiness	0.1	0.1	0.2	-0.2	-0.5	0.0	0.4
Noisy workplace	0.5	0.6	0.9	0.5	1.0	0.7	0.9
Qualifications: A levels/AS levels or equivalent	1.2	2.6	7.2	1.6	-2.7	-0.7	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.1	-0.2	0.6	0.7
Mouth/teeth dental problems: Dentures	0.9	1.6	3.1	0.6	-0.9	1.8	1.4
Asthma	0.1	0.2	0.5	-0.2	-0.3	-0.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.2	-0.3	0.9	-0.8	-1.5
Medication: Cholesterol lowering	0.4	0.6	1.7	0.2	1.3	-0.5	-0.6
Depression (self-reported)	0.5	0.6	2.0	-0.0	-1.4	0.4	0.3
Medication: Lansoprazole	0.4	0.5	1.0	0.3	-0.3	0.9	1.0
Prospective memory result	0.4	0.5	1.6	-1.3	-0.0	0.4	-0.1
Lung cancer (father)	2.8	3.3	4.9	1.8	-1.3	-1.8	-2.2
Illnesses of mother	0.5	0.6	1.4	0.7	0.2	-0.7	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.0	-0.5	-0.3	-0.8	-1.0
Pulse wave Arterial Stiffness index	0.6	0.7	1.1	0.9	0.6	-1.1	-0.8
Impedance of arm (left)	0.3	1.2	2.2	-1.4	-0.6	-1.5	-0.7
Arm fat mass (right)	1.3	5.2	12.9	-0.6	0.1	2.7	3.6
Trunk predicted mass	0.1	0.8	1.5	1.2	-1.1	-0.6	-0.3
Standing height	0.6	5.6	10.0	1.7	-1.9	-3.2	-2.4
Length of working week for main job	0.5	0.5	1.1	0.5	-0.2	1.1	0.8
Exposure to tobacco smoke at home	0.8	0.9	2.1	0.8	1.4	0.9	0.2
Breastfed as a baby	0.8	1.0	1.8	0.3	0.9	-1.1	-1.3
Tense / ‘highly strung’	0.4	0.7	2.5	-1.6	-0.0	-0.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	3.7	-1.9	-1.9	0.4	0.6
Hair/balding pattern: Pattern 4	0.3	0.7	1.2	-1.1	-1.0	-0.3	-0.6
Birth weight of first child	3.2	5.8	11.9	1.3	1.3	2.8	3.5
Peak expiratory flow (PEF)	0.3	0.7	1.0	-1.0	-0.6	0.8	0.9
Pulse wave reflection index	2.7	3.3	4.8	0.7	1.9	-2.1	-2.2
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.1	-0.6	-1.0	1.4	1.4
Loud music exposure frequency	1.1	1.3	1.7	-0.9	-1.1	1.3	1.2
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	3.8	1.7	-2.0	-0.8	0.3
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	4.5	2.1	1.3	-0.2	-0.2
Blood clot in the leg (DVT)	0.4	0.6	1.3	-1.2	0.1	-0.6	-0.8
Medication: Paracetamol	0.5	0.8	0.9	-0.9	0.7	-0.9	-0.9
Headache pain in last month	0.5	0.9	2.3	-1.5	-0.8	-0.4	-0.5
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	-0.0	-0.7	0.2	0.6
Glaucoma (self-reported)	2.0	2.3	3.5	1.7	0.9	1.9	1.4
Gout (self-reported)	1.5	2.0	4.9	-2.2	-0.7	1.3	1.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	-0.3	0.5	-0.0	0.7
Medication: Amlodipine	0.2	0.2	0.9	-0.0	0.1	1.0	0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	1.1	-0.3	0.1	-0.4
Birth weight	1.2	2.6	6.3	0.7	-0.1	1.8	2.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.7	1.3	1.2	-0.2	-0.3
High blood pressure (siblings)	1.6	2.2	3.7	-1.7	-1.5	0.6	1.9
Forced vital capacity (FVC), Best measure	0.4	1.6	3.3	0.2	-0.2	-1.8	-1.7
Body fat percentage	1.8	7.1	16.6	-1.3	0.7	3.1	4.1
Leg fat percentage (right)	1.8	6.7	14.8	-1.0	0.6	3.2	3.8
Arm fat-free mass (right)	0.1	0.5	1.1	0.9	-0.2	0.6	1.1
Exposure to tobacco smoke outside home	0.1	0.2	0.5	-0.7	-0.1	0.4	-0.2
Comparative body size at age 10	0.6	1.7	2.5	0.7	1.5	1.3	1.6
Number of full brothers	6.7	8.4	15.1	-3.9	-0.5	-2.9	-3.1
Worry too long after embarrassment	1.1	1.9	3.3	-0.6	0.7	-1.8	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.2	-0.7	0.3	1.5	0.4
Wheeze or whistling in the chest in last year	0.2	0.4	0.6	0.7	0.5	0.8	0.3
Number of children fathered	0.5	0.6	1.4	-0.4	-0.5	-0.7	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.9	-1.7	-1.0	0.1	-0.4
Age at first live birth	0.4	0.7	2.5	1.6	-0.2	-0.2	0.3
Pulse wave peak to peak time	0.5	0.6	0.9	-0.7	-0.8	1.0	0.6
Health satisfaction	0.3	0.4	1.2	-0.3	-0.4	-1.1	-0.4
Shortness of breath walking on level ground	0.4	0.4	1.3	1.1	0.5	0.3	-0.3
Qualifications: College or University degree	0.5	1.5	3.8	1.5	-2.0	-0.1	0.4
Eye problems/disorders: None of the above	0.1	0.1	0.4	-0.3	0.6	-0.4	-0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	0.1	-0.8	-0.5	-0.5
Emphysema/chronic bronchitis	0.1	0.1	0.3	0.6	0.5	0.1	-0.2
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	0.5	-0.7	0.2	0.5
Neck or shoulder pain in last month	0.3	0.4	0.6	0.5	-0.5	-0.8	-0.6
Medication: Blood pressure	0.1	0.1	0.2	-0.0	-0.1	0.5	-0.3
Angina (self-reported)	1.4	1.9	3.6	1.3	0.9	-1.2	-1.9
Migraine (self-reported)	0.1	0.1	0.2	-0.4	-0.4	0.3	0.1
Medication: Ibuprofen	0.4	0.4	0.8	0.5	0.8	-0.0	-0.9
Medication: Allopurinol	1.3	1.7	3.8	-1.9	-0.8	1.1	1.1
Medication: Omeprazole	0.1	0.1	0.1	0.1	-0.2	-0.3	-0.3
Medication: Seretide 50 evohaler	0.2	0.2	0.4	-0.4	0.6	0.4	0.3
Mean time to correctly identify matches	1.7	3.3	8.4	1.6	0.3	-1.5	-2.9
Heart disease (mother)	0.6	0.8	1.4	-0.6	-0.7	0.9	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.9	1.0	0.1	-0.9	-1.4
Whole body fat mass	1.3	5.6	14.2	-1.0	0.2	2.7	3.8
Leg fat mass (right)	1.5	5.9	14.1	-0.9	0.1	2.9	3.8
Arm predicted mass (right)	0.1	0.3	0.7	0.7	0.0	0.4	0.8
Pulse rate, automated reading	0.2	0.5	1.0	-0.9	1.0	0.3	0.5
Alcohol intake frequency.	0.2	0.5	1.4	-0.5	-0.2	0.6	1.2
Comparative height size at age 10	0.1	0.8	2.1	1.4	-0.3	-1.0	-0.1
Number of full sisters	0.2	0.3	0.8	-0.3	0.9	0.5	0.2
Suffer from ‘nerves’	0.9	1.3	2.5	0.0	-1.0	-1.4	-1.6
Overall health rating	0.5	1.0	1.6	-1.2	-0.7	1.1	0.9
Chest pain or discomfort	0.9	1.2	3.6	-0.3	-1.9	1.0	0.5
Had major operations	0.2	0.2	0.5	0.4	-0.7	-0.2	0.3
Age at last live birth	0.2	0.2	0.9	0.9	0.0	-0.2	-0.1
Family relationship satisfaction	0.2	0.2	0.4	0.4	0.1	-0.6	-0.5
Leg pain on walking	1.7	2.1	4.2	-1.5	-2.1	-1.1	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	-0.7	-0.3	-0.4	0.5
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.4	1.1	0.6	1.5	1.6
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.8	0.2	1.7	1.0	1.0
Medication: Aspirin	0.2	0.2	0.4	-0.6	0.3	-0.6	-0.1
Supplements: Vitamin C	0.9	1.1	1.8	1.3	-0.9	0.5	1.2
Knee pain experienced in last month	0.7	1.2	2.9	1.7	-0.6	-1.0	-0.6
Hypertension (Self-reported)	0.0	0.1	0.2	0.4	0.2	-0.4	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.5	-0.9	-0.6	-1.5	-1.6
Illnesses of father: Heart disease	0.8	1.2	3.5	1.9	0.9	-0.4	-0.3
Illnesses of siblings: Diabetes	0.7	0.9	1.8	-0.5	-0.2	-1.2	-1.3
Smoking status: Previous	0.5	0.8	2.3	0.2	1.5	0.8	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.6	-0.4	-0.7	-0.8	-0.6
Whole body fat-free mass	0.1	0.4	0.6	0.8	-0.8	-0.0	0.5
Leg fat-free mass (right)	0.1	0.5	1.5	0.4	-0.4	0.6	1.2
Arm fat percentage (left)	1.8	7.3	17.1	-1.6	-0.2	3.1	4.1
Average weekly red wine intake	0.3	0.4	0.9	-0.0	-0.0	0.8	1.0
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.4	-1.5	-1.4	-0.0	-0.5
Mood swings	1.6	2.9	11.1	-3.3	-0.5	-0.3	-0.3
Loneliness, isolation	0.3	0.5	1.1	0.1	1.1	-0.1	-0.9
Long-standing illness, disability or infirmity	1.4	2.2	6.1	2.5	1.2	0.7	0.8
Ever had bowel cancer screening	0.2	0.3	0.6	0.2	0.8	-0.1	-0.7
Diabetes diagnosed by doctor	0.7	1.1	3.3	-1.8	0.2	-0.9	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	4.3	4.6	9.4	-3.1	-3.0	-0.2	-0.3
Friendships satisfaction	0.5	0.6	2.1	0.3	-1.4	-0.2	0.4
Qualifications: nursing, teaching	0.1	0.1	0.3	0.5	-0.3	-0.3	-0.0
Commuting to job workplace: Walk	0.0	0.0	0.1	0.1	0.3	0.2	0.1
Eye problems/disorders: Cataract	1.0	1.1	2.1	-1.2	-1.5	-0.9	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	0.3	-0.5	0.0	0.2
Medication for cholesterol	0.6	0.9	1.8	0.1	1.0	1.3	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	2.3	-0.8	-1.5	1.2	1.3
Back pain experienced in last month	0.3	0.4	0.7	0.7	0.1	0.9	0.5
Mineral and other dietary supplements	0.3	0.4	1.3	-1.1	-0.2	0.5	0.3
Breast cancer (self-reported)	0.5	0.6	1.0	0.3	0.9	1.0	0.8
Asthma (self-reported)	0.1	0.2	0.4	-0.3	-0.4	0.0	-0.7
Osteoporosis (self-reported)	0.0	0.0	0.0	-0.0	-0.1	-0.1	-0.1
Osteoarthritis (self-reported)	2.1	2.7	7.7	2.8	1.8	0.3	0.1
Medication: Aspirin	0.1	0.2	0.3	-0.5	0.5	-0.4	-0.1
Medication: Gliclazide	1.0	1.1	1.8	-0.2	1.0	-1.2	-1.3
Illnesses of father: None of the above (group 1)	0.4	0.5	0.9	0.8	-1.0	-0.2	-0.5
Smoking status: Current	0.3	0.4	0.7	0.6	-0.5	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.2	-1.5	-1.3	0.6	0.4
Whole body water mass	0.1	0.4	0.8	0.9	-0.7	0.2	0.7
Leg predicted mass (right)	0.1	0.5	1.4	0.5	-0.4	0.6	1.2
Arm fat mass (left)	1.2	5.0	12.4	-0.7	-0.3	2.6	3.5
Number of self-reported non-cancer illnesses	0.4	0.7	1.4	1.2	0.5	-0.6	-0.8
Average weekly champagne plus white wine intake	0.5	0.6	0.8	-0.9	0.8	-0.6	-0.8
Miserableness	0.5	0.9	2.3	-1.5	-1.2	0.1	-0.0
Guilty feelings	0.6	0.9	1.2	-0.8	1.1	-0.6	-1.1
Wears glasses or contact lenses	0.7	0.8	1.6	0.0	0.4	-1.2	-1.3
Ever taken oral contraceptive pill	0.3	0.4	0.6	0.2	-0.8	-0.6	-0.7
Hearing aid user	0.7	0.8	2.2	-0.4	-1.5	-0.4	-0.9
Mother’s age at death	0.9	1.1	2.3	0.3	-0.1	-1.5	-1.5
Financial situation satisfaction	0.2	0.3	0.5	0.2	0.7	0.4	0.7
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.9	0.0	-0.7	-1.7	-1.4
Commuting to job workplace: Public transport	0.9	1.1	1.5	-1.0	-0.9	-1.1	-1.2
Eye problems/disorders: Glaucoma	2.4	2.9	3.8	2.0	1.0	1.8	1.9
Medication: Blood pressure	0.6	1.2	1.5	1.2	-1.2	-1.1	-0.7
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.5	1.6	-0.0	-0.8	-1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.0	1.0	0.6	0.7	1.0
High cholesterol (Self-reported)	0.0	0.0	0.1	-0.1	-0.3	-0.3	0.0
Medication: Bendroflumethiazide	0.6	0.9	3.0	1.7	-0.4	-0.5	-0.5
Medication: Paracetamol	0.2	0.3	0.9	-0.9	0.3	-0.1	-0.2
Medication: Lisinopril	0.5	0.6	1.1	-0.9	0.2	-0.8	-1.0
Medication: Atorvastatin	0.8	1.0	3.2	0.6	1.8	0.0	0.6
Illnesses of father: High blood pressure	0.9	1.2	3.7	-1.9	-0.1	0.9	0.4
Alcohol drinker status: Never	0.3	0.3	1.0	1.0	0.4	0.3	0.3
Ever smoked	0.5	1.0	1.9	1.3	1.4	-0.2	-0.4
Basal metabolic rate	0.1	0.5	1.2	0.6	-0.6	0.5	1.1
Leg fat percentage (left)	1.7	6.2	13.1	-0.8	0.8	3.2	3.6
Arm fat-free mass (left)	0.2	0.8	2.4	1.6	-0.3	0.3	0.7
Number of operations (self-reported)	0.5	0.8	1.5	0.3	-0.2	1.2	1.2
Average weekly beer plus cider intake	0.5	0.7	1.7	-0.6	1.3	-0.8	-0.2
Irritability	0.8	1.4	3.6	-0.7	0.1	1.9	1.2
Risk taking	0.2	0.4	1.0	1.0	0.1	-0.7	-0.1
Ever had prostate specific antigen (PSA) test	1.8	2.1	4.2	0.9	-0.0	-2.0	-1.9
Fractured/broken bones in last 5 years	1.3	1.6	2.5	-1.6	-0.6	-1.2	-1.4
Age started oral contraceptive pill	0.5	0.7	1.4	0.3	0.5	1.0	1.2
Diastolic blood pressure, automated reading	0.3	1.0	2.4	-1.6	0.5	-0.8	-0.8
Ever depressed for a whole week	0.2	0.3	0.6	-0.7	0.3	-0.8	-0.2
Unable to work because of sickness or disability	0.6	0.8	1.6	-1.3	-0.5	0.9	0.8
Commuting to job workplace: Cycle	0.3	0.3	0.4	0.6	-0.6	0.2	0.6
Myopia	1.4	2.0	3.2	-0.9	-1.2	-1.6	-1.8
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	-0.6	-0.7	0.1	-0.0
Cholesterol lowering medication	0.4	0.5	1.8	-0.1	-0.5	-1.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.0	0.1	0.1	0.3	-0.3	-0.1	0.1
Pain experienced in last month	0.4	0.7	2.0	0.9	1.4	0.2	0.2
Supplements: Calcium	0.4	0.5	0.8	0.9	0.4	0.4	0.8
Basal cell carcinoma (self-reported)	0.5	0.6	1.4	-0.2	1.2	-0.8	-0.7
Heart attack/myocardial infarction (self-reported)	1.3	1.7	6.3	-0.0	2.5	0.0	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	-1.0	0.2	-0.5	-0.6
Heart disease (siblings)	1.2	1.5	3.5	-1.9	-1.3	-0.7	-0.6
Alcohol drinker status: Previous	0.4	0.5	1.4	0.7	-0.0	-1.2	-0.3
Pack years of smoking	1.1	1.7	4.6	0.7	-0.9	0.8	2.1
Impedance of whole body	0.2	1.2	2.4	-0.9	-0.2	-1.6	-1.2
Leg fat mass (left)	1.4	5.6	13.4	-0.7	0.3	2.9	3.7
Arm predicted mass (left)	0.2	0.8	2.2	1.5	-0.3	0.5	0.8