Hub : Genes

GGA1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.156 0.0510 0.00035 0.061 NA 0.029 NA 0.017 2.4e-05 NA 0.00290 NA 0.0170
2 GTEx Vagina 0.441 0.1570 0.00840 0.008 NA 0.166 NA 0.101 2.1e-01 NA 0.00013 NA 0.0027
3 TCGA Lung Adenocarcinoma 0.044 0.0233 0.00110 0.022 0.031 0.028 NA 0.022 1.1e-03 0.00012 0.00026 NA 0.0012
4 TCGA Thyroid Carcinoma 0.038 0.0190 0.00200 0.014 0.025 0.018 NA 0.014 1.3e-02 0.00170 0.00610 NA 0.0140

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.6 1.0 1.6 -0.8 0.3 1.2 1.3
Bipolar Disorder or Schizophrenia 0.3 0.6 1.2 0.6 0.1 1.0 1.1
Depressed Affect (Nagel 2018) 0.3 0.6 2.1 -1.4 0.5 0.3 -0.1
Depression (Nagel 2018) 0.2 0.2 0.4 0.6 -0.4 0.1 -0.6
Intelligence (Savage-Jansen 2018) 1.6 5.0 8.2 2.2 -0.0 -2.9 -2.6
Neuroticism (Nagel 2018) 0.3 0.6 1.4 -1.2 0.1 -0.4 -0.9
Schizophrenia (2018) 0.2 0.5 1.7 1.3 -0.2 0.3 0.4
Schizophrenia vs Biploar Disorder 1.0 1.4 3.7 1.9 1.3 0.2 -0.4
Worry (Nagel 2018) 0.7 1.4 2.5 -0.7 -0.1 -1.6 -1.6
Alzheimer’s Disease (in mother) 2.0 2.3 4.6 2.2 1.9 0.9 0.5
Alzheimer’s Disease (in father) 0.2 0.2 0.8 0.3 -0.1 -0.9 0.2
Alzheimer’s Disease (including proxy) 0.8 1.2 2.2 1.5 0.9 0.8 1.0
Crohns Disease (2017) 0.3 0.6 0.9 0.5 0.9 0.9 -0.6
Irritable Bowel Disease (IBD) 0.2 0.6 1.7 -0.7 1.3 -0.1 -0.4
Ulcerative Colitis (UC) 0.4 0.7 1.6 -0.9 1.3 -0.6 0.2
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 1.5 2.9 5.8 1.4 -0.3 -2.0 -2.4
Verbal and Numeric Reasoning (VNR) 1.6 3.7 5.3 2.0 -0.9 -2.3 -2.2
Breast Cancer 1.5 3.6 6.2 -1.5 -2.5 1.3 2.0
Ovarian Cancer 1.4 1.9 4.5 2.1 -1.4 0.4 1.0
Prostate Cancer 0.7 1.0 2.6 -0.4 -0.2 -1.6 -1.1
Age at First Birth 1.5 2.1 8.0 2.8 0.3 0.6 -0.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.2 0.3 0.7 -0.8 0.3 0.6 0.2
Coronary Artery Disease (CAD) 1.3 1.6 4.8 -0.4 2.2 -0.9 -0.9
Crohns Disease (2012) 0.8 1.2 2.8 0.8 1.7 -0.5 -1.1
Mean Putamen Volume 1.3 1.5 3.4 -1.8 -0.9 1.2 0.7
Fasting Glucose 0.1 0.1 0.4 0.2 -0.0 -0.6 -0.2
HbA1C 1.1 1.2 3.5 0.4 -1.9 -0.9 -0.6
HDL Cholesterol 0.2 0.4 0.7 0.8 0.4 0.6 0.5
LDL Cholesterol 0.7 1.1 1.8 1.1 1.3 -0.5 -1.1
Lupus 1.4 2.1 4.6 -1.7 2.1 0.9 0.3
Neuroticism (2016) 0.6 0.9 1.5 -1.1 -0.8 -0.5 -1.2
Primary Biliary Cirrhosis 0.3 0.4 1.3 -0.4 0.2 -0.4 -1.1
Rheumatoid Arthritis 1.0 1.4 3.4 -0.4 -0.0 -1.8 -1.4
Schizophrenia (2014) 0.3 0.6 1.9 1.4 -0.3 0.2 0.7
Triglycerides 0.2 0.3 0.6 -0.6 -0.4 -0.0 0.8
Type 2 Diabetes (T2D) (2012) 1.0 1.1 2.9 1.1 1.7 -0.3 -0.6
Ulcerative Colitis 0.3 0.5 1.5 -0.1 0.0 -1.2 0.6
Blood Eosinophil Count 0.4 3.2 4.2 1.8 -1.5 2.0 1.7
Blood Platelet Count 0.6 7.5 13.4 -3.7 -2.7 2.4 1.8
Blood Red Count 0.4 3.8 8.2 -1.4 0.7 2.1 2.9
Blood White Count 0.4 3.0 6.4 -0.5 0.0 2.3 2.5
Heel T-Score 1.5 12.2 20.0 -3.4 -1.0 4.0 4.5
BMI 2.6 15.0 34.4 -0.1 -0.1 5.1 5.9
Height 0.8 15.5 31.0 3.5 -0.5 -5.6 -4.3
Waist Hip Ratio (WHR) 0.3 1.3 3.0 -1.7 -1.1 -0.3 -0.8
Systolic Blood Pressure 0.4 1.8 5.0 -2.2 -1.0 0.9 0.7
Smoking Status 0.2 0.4 0.8 0.5 0.4 -0.6 -0.9
Allergy or Eczema 0.0 0.0 0.1 0.1 -0.3 0.1 0.1
Cardiovascular Disease 0.1 0.3 0.6 -0.3 0.2 0.7 0.6
Hypothyroidism (self reported) 0.2 0.5 0.9 -0.5 0.3 1.0 0.8
Respiratory disease 0.6 1.4 3.1 -0.1 -0.8 -1.4 -1.8
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.7 -1.3 -0.7 -0.9 -0.6
Lung FEV1/FVC ratio 0.4 2.3 6.0 -0.3 0.0 2.5 1.7
Lung FVC 0.2 1.1 2.6 0.8 0.4 -1.0 -1.6
Neuroticism 0.2 0.5 1.7 -1.3 0.3 0.3 -0.1
Chronotype (morning person) 0.5 1.3 3.2 0.9 1.8 -0.6 -0.9
Hair Pigment 0.0 0.1 0.2 0.4 -0.0 -0.3 -0.2
Tanning 0.4 5.5 7.0 2.6 1.9 -2.2 -2.5
Hand grip strength (left) 0.2 0.6 2.1 0.3 0.0 0.6 1.5
Number of treatments/medications taken 0.9 1.7 3.6 1.9 1.7 0.0 -0.4
Average weekly spirits intake 0.3 0.3 0.5 0.6 0.5 0.4 0.7
Sensitivity / hurt feelings 0.7 1.2 3.5 -1.9 -0.3 -0.5 -1.0
Frequency of depressed mood in last 2 weeks 0.9 1.3 4.6 -0.1 0.2 -0.8 -2.1
Hearing difficulty/problems: Yes 0.8 1.2 2.2 -1.5 -1.4 -0.7 -0.0
Relative age of first facial hair 0.5 1.1 3.0 1.7 -0.1 -0.5 1.0
Other serious medical condition/disability diagnosed by doctor 0.0 0.0 0.1 0.3 -0.2 -0.1 -0.0
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.2 1.1 0.0 1.1 0.9
Ever had hysterectomy (womb removed) 0.4 0.5 0.8 -0.8 -0.4 -0.9 -0.5
Systolic blood pressure, automated reading 0.2 0.6 2.2 -1.5 -0.6 0.1 -0.1
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.2 0.1 -0.6 0.9 1.1
Angina 1.7 2.2 3.6 1.6 1.0 -1.3 -1.9
Medication for hormone replacement therapy 0.5 0.6 1.5 -0.8 -1.2 0.2 0.2
Vitamin and mineral supplements 0.5 0.6 1.9 -1.4 0.0 -0.3 -0.7
Supplements: Zinc 2.0 2.2 7.3 -1.2 -2.7 -0.1 0.0
Medication: Co-codamol 0.0 0.1 0.2 -0.0 -0.4 -0.1 0.1
Medication: Metformin 0.4 0.6 1.2 -0.8 0.3 -1.1 -0.6
Diabetes (father) 0.8 1.0 2.9 -1.7 -0.4 -0.9 -0.1
Diabetes (mother) 2.5 3.2 7.1 -2.7 -2.0 0.7 1.2
Severe depression (siblings) 0.2 0.2 0.8 -0.9 -0.2 -0.1 -0.3
Pack years adult smoking proportion 1.2 1.8 5.1 0.3 -1.0 0.9 2.2
Impedance of leg (right) 0.1 0.5 1.0 -0.5 -0.1 -1.0 -0.9
Leg fat-free mass (left) 0.2 1.1 3.1 0.2 -0.5 1.0 1.8
Trunk fat percentage 1.6 6.2 15.6 -1.1 0.8 2.7 4.0
Hand grip strength (right) 0.1 0.2 0.3 0.2 -0.5 -0.5 0.4
Townsend deprivation index at recruitment 0.3 0.5 0.8 -0.3 0.5 0.9 0.9
Current tobacco smoking 0.5 0.9 1.4 0.7 -0.5 -1.2 -1.1
Average weekly fortified wine intake 0.9 1.1 1.5 1.1 0.0 -1.2 -1.2
Maternal smoking around birth 0.6 0.8 1.6 1.1 -1.3 0.4 -0.6
Fed-up feelings 0.4 0.8 2.5 -1.6 0.3 0.5 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.4 0.6 -0.7 1.2 0.9
Relative age voice broke 0.2 0.4 1.2 -0.3 0.0 0.4 1.1
Taking other prescription medications 0.2 0.2 0.6 0.8 0.4 -0.4 -0.3
Age when periods started (menarche) 0.2 0.4 1.3 0.0 -0.3 -0.5 -1.2
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.4 -0.2 0.1 -0.9 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.6 5.2 -1.6 0.1 1.6 2.3
Tinnitus: Yes, but not now, but have in the past 1.8 2.0 4.7 2.2 1.5 0.6 0.8
Qualifications: CSEs or equivalent 0.4 0.5 0.8 0.8 0.9 -0.3 -0.7
Serious illness, injury or assault to yourself 0.1 0.2 0.4 -0.0 0.0 0.6 0.6
High blood pressure 0.0 0.1 0.3 0.1 -0.2 -0.6 -0.3
Hayfever, allergic rhinitis or eczema 0.4 0.9 3.2 0.0 -1.8 0.1 0.4
Multivitamins +/- minerals 0.5 0.7 2.5 1.6 0.4 0.1 0.2
Stomach or abdominal pain in last month 0.5 0.6 1.6 -0.7 -1.3 0.6 0.3
Supplements: Glucosamine 1.0 1.3 3.4 1.8 0.5 -0.7 -1.0
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.8 -0.9 -0.2 -0.2 -0.5
Medication: Atenolol 3.2 4.0 9.9 3.1 2.4 0.2 -0.2
Medication: Levothyroxine sodium 0.1 0.2 0.6 -0.2 0.7 0.4 0.5
Sitting height 0.6 4.4 8.6 1.0 -1.2 -2.9 -2.5
Chronic bronchitis/emphysema (father) 0.3 0.4 1.1 0.1 1.1 -0.7 -0.2
High blood pressure (mother) 0.3 0.4 0.9 -0.4 -0.9 -0.3 0.6
Body mass index (BMI) 1.4 6.1 14.3 -0.5 0.5 3.1 3.8
Impedance of leg (left) 0.2 0.9 1.7 -0.6 0.2 -1.2 -1.3
Leg predicted mass (left) 0.2 1.0 3.0 0.2 -0.5 0.9 1.7
Trunk fat mass 1.0 4.5 11.9 -1.0 0.2 2.3 3.4
Waist circumference 0.7 2.7 6.8 -0.5 -0.3 1.9 2.6
Number of incorrect matches in round 1.0 1.6 2.6 -1.0 0.8 1.4 1.6
Past tobacco smoking 0.7 1.4 4.6 -0.8 -2.1 -0.3 0.4
Alcohol usually taken with meals 0.8 1.3 2.1 1.4 -1.4 0.8 0.6
Nervous feelings 0.6 1.0 2.2 -0.6 -0.7 -1.5 -1.0
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.1 -0.1 0.4 1.0 0.3
Hearing difficulty/problems with background noise 1.0 1.6 5.0 -2.2 -1.1 -0.2 0.5
Hair/balding pattern: Pattern 2 0.2 0.3 0.6 0.6 0.2 0.5 0.8
Had menopause 2.3 2.9 5.9 2.4 1.1 1.3 1.7
Had other major operations 1.3 1.6 3.0 1.2 0.6 1.7 1.2
Forced vital capacity (FVC) 0.3 1.3 2.7 0.1 -1.1 -1.6 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 4.2 -1.6 -0.2 1.6 2.0
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.6 -1.3 -0.8 0.5 1.0
Qualifications: None of the above 0.4 1.0 2.7 -1.0 1.6 0.1 -0.3
Financial difficulties in last 2 years 0.3 0.4 1.4 -0.0 -1.2 -0.0 -0.3
Mouth/teeth dental problems 0.5 0.8 1.5 -1.0 0.2 -1.2 -0.8
Heart attack 1.2 1.5 5.3 -0.2 2.3 -0.0 -0.8
Allergy 0.2 0.4 1.2 -0.2 1.1 -0.3 -0.4
Pain all over the body in last month 0.6 0.6 1.7 -1.3 -0.9 0.1 -0.2
Diabetes (self-reported) 0.3 0.4 1.1 -1.1 0.5 -0.5 -0.4
Hayfever/allergic rhinitis (self-reported) 0.9 1.1 2.3 -0.3 -0.4 -1.5 -1.4
Medication: Ramipril 1.6 2.1 4.2 1.4 0.1 -2.0 -1.4
Medication: Simvastatin 0.5 0.8 1.8 0.2 -0.4 -1.3 -1.0
Fluid intelligence score 1.7 3.4 4.8 1.9 -1.6 -2.2 -1.7
Illnesses of siblings 0.5 0.8 2.0 1.4 0.7 0.4 -0.6
Neuroticism score 0.4 0.9 2.8 -1.7 0.2 -0.4 -0.8
Weight 0.4 2.1 6.1 0.1 -0.4 1.5 2.5
Impedance of arm (right) 0.1 0.5 1.0 -0.7 -0.7 -1.0 -0.5
Arm fat percentage (right) 1.7 6.7 16.0 -1.1 -0.1 3.1 4.0
Trunk fat-free mass 0.1 0.8 1.4 1.2 -1.1 -0.6 -0.4
Hip circumference 0.5 2.0 5.2 0.6 0.1 1.5 2.3
Time employed in main current job 0.2 0.2 0.5 -0.4 0.1 0.5 0.7
Alcohol intake versus 10 years previously 0.5 0.7 1.5 -1.2 -0.6 -0.1 0.9
Father’s age at death 0.2 0.3 0.7 0.8 0.5 -0.0 0.2
Worrier / anxious feelings 1.2 2.2 3.5 -1.7 -0.3 -1.6 -1.9
Frequency of tiredness / lethargy in last 2 weeks 2.2 3.5 6.4 -1.1 0.4 2.5 2.5
Falls in the last year 0.6 0.9 1.6 -1.3 -0.9 0.3 1.0
Hair/balding pattern: Pattern 3 0.1 0.2 0.4 0.3 0.7 0.2 -0.2
Number of live births 0.2 0.3 1.1 0.2 0.4 1.0 0.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.0 -0.5 -1.0 -0.9 -0.6
Pulse rate 0.3 0.4 0.8 0.1 0.9 0.8 0.5
Happiness 0.1 0.1 0.2 -0.2 -0.5 0.0 0.4
Noisy workplace 0.5 0.6 0.9 0.5 1.0 0.7 0.9
Qualifications: A levels/AS levels or equivalent 1.2 2.6 7.2 1.6 -2.7 -0.7 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.5 0.1 -0.2 0.6 0.7
Mouth/teeth dental problems: Dentures 0.9 1.6 3.1 0.6 -0.9 1.8 1.4
Asthma 0.1 0.2 0.5 -0.2 -0.3 -0.1 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.2 -0.3 0.9 -0.8 -1.5
Medication: Cholesterol lowering 0.4 0.6 1.7 0.2 1.3 -0.5 -0.6
Depression (self-reported) 0.5 0.6 2.0 -0.0 -1.4 0.4 0.3
Medication: Lansoprazole 0.4 0.5 1.0 0.3 -0.3 0.9 1.0
Prospective memory result 0.4 0.5 1.6 -1.3 -0.0 0.4 -0.1
Lung cancer (father) 2.8 3.3 4.9 1.8 -1.3 -1.8 -2.2
Illnesses of mother 0.5 0.6 1.4 0.7 0.2 -0.7 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 1.0 -0.5 -0.3 -0.8 -1.0
Pulse wave Arterial Stiffness index 0.6 0.7 1.1 0.9 0.6 -1.1 -0.8
Impedance of arm (left) 0.3 1.2 2.2 -1.4 -0.6 -1.5 -0.7
Arm fat mass (right) 1.3 5.2 12.9 -0.6 0.1 2.7 3.6
Trunk predicted mass 0.1 0.8 1.5 1.2 -1.1 -0.6 -0.3
Standing height 0.6 5.6 10.0 1.7 -1.9 -3.2 -2.4
Length of working week for main job 0.5 0.5 1.1 0.5 -0.2 1.1 0.8
Exposure to tobacco smoke at home 0.8 0.9 2.1 0.8 1.4 0.9 0.2
Breastfed as a baby 0.8 1.0 1.8 0.3 0.9 -1.1 -1.3
Tense / ‘highly strung’ 0.4 0.7 2.5 -1.6 -0.0 -0.2 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 1.9 3.7 -1.9 -1.9 0.4 0.6
Hair/balding pattern: Pattern 4 0.3 0.7 1.2 -1.1 -1.0 -0.3 -0.6
Birth weight of first child 3.2 5.8 11.9 1.3 1.3 2.8 3.5
Peak expiratory flow (PEF) 0.3 0.7 1.0 -1.0 -0.6 0.8 0.9
Pulse wave reflection index 2.7 3.3 4.8 0.7 1.9 -2.1 -2.2
Ever highly irritable/argumentative for 2 days 1.1 1.3 2.1 -0.6 -1.0 1.4 1.4
Loud music exposure frequency 1.1 1.3 1.7 -0.9 -1.1 1.3 1.2
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 3.8 1.7 -2.0 -0.8 0.3
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 4.5 2.1 1.3 -0.2 -0.2
Blood clot in the leg (DVT) 0.4 0.6 1.3 -1.2 0.1 -0.6 -0.8
Medication: Paracetamol 0.5 0.8 0.9 -0.9 0.7 -0.9 -0.9
Headache pain in last month 0.5 0.9 2.3 -1.5 -0.8 -0.4 -0.5
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.4 -0.0 -0.7 0.2 0.6
Glaucoma (self-reported) 2.0 2.3 3.5 1.7 0.9 1.9 1.4
Gout (self-reported) 1.5 2.0 4.9 -2.2 -0.7 1.3 1.1
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.4 -0.3 0.5 -0.0 0.7
Medication: Amlodipine 0.2 0.2 0.9 -0.0 0.1 1.0 0.2
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.3 1.1 -0.3 0.1 -0.4
Birth weight 1.2 2.6 6.3 0.7 -0.1 1.8 2.5
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.7 1.3 1.2 -0.2 -0.3
High blood pressure (siblings) 1.6 2.2 3.7 -1.7 -1.5 0.6 1.9
Forced vital capacity (FVC), Best measure 0.4 1.6 3.3 0.2 -0.2 -1.8 -1.7
Body fat percentage 1.8 7.1 16.6 -1.3 0.7 3.1 4.1
Leg fat percentage (right) 1.8 6.7 14.8 -1.0 0.6 3.2 3.8
Arm fat-free mass (right) 0.1 0.5 1.1 0.9 -0.2 0.6 1.1
Exposure to tobacco smoke outside home 0.1 0.2 0.5 -0.7 -0.1 0.4 -0.2
Comparative body size at age 10 0.6 1.7 2.5 0.7 1.5 1.3 1.6
Number of full brothers 6.7 8.4 15.1 -3.9 -0.5 -2.9 -3.1
Worry too long after embarrassment 1.1 1.9 3.3 -0.6 0.7 -1.8 -1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.2 -0.7 0.3 1.5 0.4
Wheeze or whistling in the chest in last year 0.2 0.4 0.6 0.7 0.5 0.8 0.3
Number of children fathered 0.5 0.6 1.4 -0.4 -0.5 -0.7 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 2.9 -1.7 -1.0 0.1 -0.4
Age at first live birth 0.4 0.7 2.5 1.6 -0.2 -0.2 0.3
Pulse wave peak to peak time 0.5 0.6 0.9 -0.7 -0.8 1.0 0.6
Health satisfaction 0.3 0.4 1.2 -0.3 -0.4 -1.1 -0.4
Shortness of breath walking on level ground 0.4 0.4 1.3 1.1 0.5 0.3 -0.3
Qualifications: College or University degree 0.5 1.5 3.8 1.5 -2.0 -0.1 0.4
Eye problems/disorders: None of the above 0.1 0.1 0.4 -0.3 0.6 -0.4 -0.1
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.6 0.1 -0.8 -0.5 -0.5
Emphysema/chronic bronchitis 0.1 0.1 0.3 0.6 0.5 0.1 -0.2
Medication for pain relief, constipation, heartburn 0.2 0.3 0.5 0.5 -0.7 0.2 0.5
Neck or shoulder pain in last month 0.3 0.4 0.6 0.5 -0.5 -0.8 -0.6
Medication: Blood pressure 0.1 0.1 0.2 -0.0 -0.1 0.5 -0.3
Angina (self-reported) 1.4 1.9 3.6 1.3 0.9 -1.2 -1.9
Migraine (self-reported) 0.1 0.1 0.2 -0.4 -0.4 0.3 0.1
Medication: Ibuprofen 0.4 0.4 0.8 0.5 0.8 -0.0 -0.9
Medication: Allopurinol 1.3 1.7 3.8 -1.9 -0.8 1.1 1.1
Medication: Omeprazole 0.1 0.1 0.1 0.1 -0.2 -0.3 -0.3
Medication: Seretide 50 evohaler 0.2 0.2 0.4 -0.4 0.6 0.4 0.3
Mean time to correctly identify matches 1.7 3.3 8.4 1.6 0.3 -1.5 -2.9
Heart disease (mother) 0.6 0.8 1.4 -0.6 -0.7 0.9 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 1.9 1.0 0.1 -0.9 -1.4
Whole body fat mass 1.3 5.6 14.2 -1.0 0.2 2.7 3.8
Leg fat mass (right) 1.5 5.9 14.1 -0.9 0.1 2.9 3.8
Arm predicted mass (right) 0.1 0.3 0.7 0.7 0.0 0.4 0.8
Pulse rate, automated reading 0.2 0.5 1.0 -0.9 1.0 0.3 0.5
Alcohol intake frequency. 0.2 0.5 1.4 -0.5 -0.2 0.6 1.2
Comparative height size at age 10 0.1 0.8 2.1 1.4 -0.3 -1.0 -0.1
Number of full sisters 0.2 0.3 0.8 -0.3 0.9 0.5 0.2
Suffer from ‘nerves’ 0.9 1.3 2.5 0.0 -1.0 -1.4 -1.6
Overall health rating 0.5 1.0 1.6 -1.2 -0.7 1.1 0.9
Chest pain or discomfort 0.9 1.2 3.6 -0.3 -1.9 1.0 0.5
Had major operations 0.2 0.2 0.5 0.4 -0.7 -0.2 0.3
Age at last live birth 0.2 0.2 0.9 0.9 0.0 -0.2 -0.1
Family relationship satisfaction 0.2 0.2 0.4 0.4 0.1 -0.6 -0.5
Leg pain on walking 1.7 2.1 4.2 -1.5 -2.1 -1.1 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.5 -0.7 -0.3 -0.4 0.5
Commuting to job workplace: Car/motor vehicle 1.4 1.6 2.4 1.1 0.6 1.5 1.6
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.8 0.2 1.7 1.0 1.0
Medication: Aspirin 0.2 0.2 0.4 -0.6 0.3 -0.6 -0.1
Supplements: Vitamin C 0.9 1.1 1.8 1.3 -0.9 0.5 1.2
Knee pain experienced in last month 0.7 1.2 2.9 1.7 -0.6 -1.0 -0.6
Hypertension (Self-reported) 0.0 0.1 0.2 0.4 0.2 -0.4 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 2.5 -0.9 -0.6 -1.5 -1.6
Illnesses of father: Heart disease 0.8 1.2 3.5 1.9 0.9 -0.4 -0.3
Illnesses of siblings: Diabetes 0.7 0.9 1.8 -0.5 -0.2 -1.2 -1.3
Smoking status: Previous 0.5 0.8 2.3 0.2 1.5 0.8 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.6 -0.4 -0.7 -0.8 -0.6
Whole body fat-free mass 0.1 0.4 0.6 0.8 -0.8 -0.0 0.5
Leg fat-free mass (right) 0.1 0.5 1.5 0.4 -0.4 0.6 1.2
Arm fat percentage (left) 1.8 7.3 17.1 -1.6 -0.2 3.1 4.1
Average weekly red wine intake 0.3 0.4 0.9 -0.0 -0.0 0.8 1.0
Handedness (chirality/laterality): Left-handed 1.0 1.2 2.4 -1.5 -1.4 -0.0 -0.5
Mood swings 1.6 2.9 11.1 -3.3 -0.5 -0.3 -0.3
Loneliness, isolation 0.3 0.5 1.1 0.1 1.1 -0.1 -0.9
Long-standing illness, disability or infirmity 1.4 2.2 6.1 2.5 1.2 0.7 0.8
Ever had bowel cancer screening 0.2 0.3 0.6 0.2 0.8 -0.1 -0.7
Diabetes diagnosed by doctor 0.7 1.1 3.3 -1.8 0.2 -0.9 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 4.3 4.6 9.4 -3.1 -3.0 -0.2 -0.3
Friendships satisfaction 0.5 0.6 2.1 0.3 -1.4 -0.2 0.4
Qualifications: nursing, teaching 0.1 0.1 0.3 0.5 -0.3 -0.3 -0.0
Commuting to job workplace: Walk 0.0 0.0 0.1 0.1 0.3 0.2 0.1
Eye problems/disorders: Cataract 1.0 1.1 2.1 -1.2 -1.5 -0.9 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.3 0.3 -0.5 0.0 0.2
Medication for cholesterol 0.6 0.9 1.8 0.1 1.0 1.3 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 2.3 -0.8 -1.5 1.2 1.3
Back pain experienced in last month 0.3 0.4 0.7 0.7 0.1 0.9 0.5
Mineral and other dietary supplements 0.3 0.4 1.3 -1.1 -0.2 0.5 0.3
Breast cancer (self-reported) 0.5 0.6 1.0 0.3 0.9 1.0 0.8
Asthma (self-reported) 0.1 0.2 0.4 -0.3 -0.4 0.0 -0.7
Osteoporosis (self-reported) 0.0 0.0 0.0 -0.0 -0.1 -0.1 -0.1
Osteoarthritis (self-reported) 2.1 2.7 7.7 2.8 1.8 0.3 0.1
Medication: Aspirin 0.1 0.2 0.3 -0.5 0.5 -0.4 -0.1
Medication: Gliclazide 1.0 1.1 1.8 -0.2 1.0 -1.2 -1.3
Illnesses of father: None of the above (group 1) 0.4 0.5 0.9 0.8 -1.0 -0.2 -0.5
Smoking status: Current 0.3 0.4 0.7 0.6 -0.5 -0.8 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 2.2 -1.5 -1.3 0.6 0.4
Whole body water mass 0.1 0.4 0.8 0.9 -0.7 0.2 0.7
Leg predicted mass (right) 0.1 0.5 1.4 0.5 -0.4 0.6 1.2
Arm fat mass (left) 1.2 5.0 12.4 -0.7 -0.3 2.6 3.5
Number of self-reported non-cancer illnesses 0.4 0.7 1.4 1.2 0.5 -0.6 -0.8
Average weekly champagne plus white wine intake 0.5 0.6 0.8 -0.9 0.8 -0.6 -0.8
Miserableness 0.5 0.9 2.3 -1.5 -1.2 0.1 -0.0
Guilty feelings 0.6 0.9 1.2 -0.8 1.1 -0.6 -1.1
Wears glasses or contact lenses 0.7 0.8 1.6 0.0 0.4 -1.2 -1.3
Ever taken oral contraceptive pill 0.3 0.4 0.6 0.2 -0.8 -0.6 -0.7
Hearing aid user 0.7 0.8 2.2 -0.4 -1.5 -0.4 -0.9
Mother’s age at death 0.9 1.1 2.3 0.3 -0.1 -1.5 -1.5
Financial situation satisfaction 0.2 0.3 0.5 0.2 0.7 0.4 0.7
Tinnitus: Yes, now most or all of the time 1.1 1.3 2.9 0.0 -0.7 -1.7 -1.4
Commuting to job workplace: Public transport 0.9 1.1 1.5 -1.0 -0.9 -1.1 -1.2
Eye problems/disorders: Glaucoma 2.4 2.9 3.8 2.0 1.0 1.8 1.9
Medication: Blood pressure 0.6 1.2 1.5 1.2 -1.2 -1.1 -0.7
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.5 1.6 -0.0 -0.8 -1.0
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.0 1.0 0.6 0.7 1.0
High cholesterol (Self-reported) 0.0 0.0 0.1 -0.1 -0.3 -0.3 0.0
Medication: Bendroflumethiazide 0.6 0.9 3.0 1.7 -0.4 -0.5 -0.5
Medication: Paracetamol 0.2 0.3 0.9 -0.9 0.3 -0.1 -0.2
Medication: Lisinopril 0.5 0.6 1.1 -0.9 0.2 -0.8 -1.0
Medication: Atorvastatin 0.8 1.0 3.2 0.6 1.8 0.0 0.6
Illnesses of father: High blood pressure 0.9 1.2 3.7 -1.9 -0.1 0.9 0.4
Alcohol drinker status: Never 0.3 0.3 1.0 1.0 0.4 0.3 0.3
Ever smoked 0.5 1.0 1.9 1.3 1.4 -0.2 -0.4
Basal metabolic rate 0.1 0.5 1.2 0.6 -0.6 0.5 1.1
Leg fat percentage (left) 1.7 6.2 13.1 -0.8 0.8 3.2 3.6
Arm fat-free mass (left) 0.2 0.8 2.4 1.6 -0.3 0.3 0.7
Number of operations (self-reported) 0.5 0.8 1.5 0.3 -0.2 1.2 1.2
Average weekly beer plus cider intake 0.5 0.7 1.7 -0.6 1.3 -0.8 -0.2
Irritability 0.8 1.4 3.6 -0.7 0.1 1.9 1.2
Risk taking 0.2 0.4 1.0 1.0 0.1 -0.7 -0.1
Ever had prostate specific antigen (PSA) test 1.8 2.1 4.2 0.9 -0.0 -2.0 -1.9
Fractured/broken bones in last 5 years 1.3 1.6 2.5 -1.6 -0.6 -1.2 -1.4
Age started oral contraceptive pill 0.5 0.7 1.4 0.3 0.5 1.0 1.2
Diastolic blood pressure, automated reading 0.3 1.0 2.4 -1.6 0.5 -0.8 -0.8
Ever depressed for a whole week 0.2 0.3 0.6 -0.7 0.3 -0.8 -0.2
Unable to work because of sickness or disability 0.6 0.8 1.6 -1.3 -0.5 0.9 0.8
Commuting to job workplace: Cycle 0.3 0.3 0.4 0.6 -0.6 0.2 0.6
Myopia 1.4 2.0 3.2 -0.9 -1.2 -1.6 -1.8
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.4 -0.6 -0.7 0.1 -0.0
Cholesterol lowering medication 0.4 0.5 1.8 -0.1 -0.5 -1.3 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.0 0.1 0.1 0.3 -0.3 -0.1 0.1
Pain experienced in last month 0.4 0.7 2.0 0.9 1.4 0.2 0.2
Supplements: Calcium 0.4 0.5 0.8 0.9 0.4 0.4 0.8
Basal cell carcinoma (self-reported) 0.5 0.6 1.4 -0.2 1.2 -0.8 -0.7
Heart attack/myocardial infarction (self-reported) 1.3 1.7 6.3 -0.0 2.5 0.0 -0.8
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.0 -1.0 0.2 -0.5 -0.6
Heart disease (siblings) 1.2 1.5 3.5 -1.9 -1.3 -0.7 -0.6
Alcohol drinker status: Previous 0.4 0.5 1.4 0.7 -0.0 -1.2 -0.3
Pack years of smoking 1.1 1.7 4.6 0.7 -0.9 0.8 2.1
Impedance of whole body 0.2 1.2 2.4 -0.9 -0.2 -1.6 -1.2
Leg fat mass (left) 1.4 5.6 13.4 -0.7 0.3 2.9 3.7
Arm predicted mass (left) 0.2 0.8 2.2 1.5 -0.3 0.5 0.8