Hub : Genes

GGPS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1810	0.0400	0.0e+00	0.212	0.221	0.238	0.238	0.226	2.5e-25	2.0e-26	1.1e-28	1.3e-28	4.2e-27
2	GTEx	Adipose Subcutaneous	0.1190	0.0450	1.1e-03	0.051	NA	0.030	NA	0.047	5.5e-05	NA	1.7e-03	NA	1.0e-04
3	GTEx	Cells Transformed fibroblasts	0.0770	0.0330	3.9e-03	0.060	NA	0.038	NA	0.040	2.9e-05	NA	7.3e-04	NA	5.8e-04
4	GTEx	Lung	0.1146	0.0404	1.9e-04	0.074	NA	0.058	NA	0.066	2.7e-06	NA	2.8e-05	NA	9.1e-06
5	GTEx	Nerve Tibial	0.2403	0.0493	5.2e-11	0.231	NA	0.233	NA	0.226	2.4e-16	NA	1.6e-16	NA	5.7e-16
6	GTEx	Whole Blood	0.0880	0.0350	9.3e-04	0.057	NA	0.028	NA	0.043	5.7e-06	NA	1.2e-03	NA	6.9e-05
7	NTR	Blood	0.0309	0.0096	3.7e-08	0.029	0.025	0.025	0.027	0.030	6.5e-10	9.7e-09	1.6e-08	2.6e-09	5.0e-10
8	YFS	Blood	0.0793	0.0178	0.0e+00	0.093	0.099	0.106	0.106	0.100	9.3e-29	8.9e-31	9.8e-33	1.1e-32	6.2e-31
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0761	0.0324	3.2e-08	0.079	0.072	0.085	NA	0.077	3.6e-09	1.8e-08	8.7e-10	NA	4.9e-09
10	TCGA	Brain Lower Grade Glioma	0.0887	0.0408	7.8e-08	0.070	0.079	0.080	NA	0.077	2.0e-08	2.6e-09	2.3e-09	NA	4.5e-09
11	TCGA	Thyroid Carcinoma	0.0490	0.0290	1.9e-03	0.013	0.004	0.016	NA	0.005	1.6e-02	1.1e-01	9.6e-03	NA	9.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.0	0.1	0.3	-0.0	-0.5	0.0	-0.2	-0.0	-0.4	-0.3	0.1	-0.1	0.1	-0.4
Bipolar Disorder or Schizophrenia	0.2	0.6	1.9	-0.7	-0.7	0.8	-0.9	-0.8	-1.1	-0.2	0.1	-0.7	-1.4	-0.1
Depressed Affect (Nagel 2018)	0.8	1.6	3.1	1.0	-1.0	1.5	-1.4	-1.5	-1.4	-0.6	-0.7	-1.5	-1.8	-1.2
Depression (Nagel 2018)	2.3	3.5	5.6	1.4	-1.8	2.2	-1.9	-2.4	-2.1	-1.1	-1.2	-2.0	-1.9	-2.0
Intelligence (Savage-Jansen 2018)	1.6	5.0	15.0	-3.3	0.4	-1.4	1.3	1.0	1.2	3.5	3.9	0.9	1.4	3.0
Neuroticism (Nagel 2018)	1.4	3.3	5.9	1.2	-1.7	1.9	-2.2	-2.0	-1.8	-1.2	-1.4	-2.1	-2.4	-1.5
Schizophrenia (2018)	0.4	0.8	3.2	-0.9	-0.5	1.0	-0.9	-1.0	-1.1	-0.0	0.0	-0.8	-1.8	0.2
Schizophrenia vs Biploar Disorder	0.4	0.5	1.4	1.2	0.5	-0.2	0.6	0.2	0.4	-1.0	-1.0	0.6	-0.4	-0.3
Worry (Nagel 2018)	1.7	3.6	5.4	2.3	-1.4	1.7	-1.7	-1.7	-1.8	-2.3	-2.3	-1.4	-1.9	-1.9
Alzheimer’s Disease (in mother)	0.5	0.6	2.5	-0.5	1.6	-0.7	0.5	1.1	0.8	-0.3	-0.2	0.7	0.8	-0.4
Alzheimer’s Disease (in father)	1.5	1.6	5.9	-1.6	0.8	-0.6	0.6	0.5	0.2	1.9	2.4	0.3	0.6	1.8
Alzheimer’s Disease (including proxy)	0.3	0.4	1.6	-0.8	1.3	-0.4	0.4	0.8	0.3	0.3	0.4	0.5	0.5	0.2
Crohns Disease (2017)	0.9	2.0	3.4	-0.3	-1.8	1.6	-1.8	-1.4	-1.8	-0.5	-0.6	-1.8	-1.5	-1.1
Irritable Bowel Disease (IBD)	0.2	0.6	2.2	-0.7	-1.5	0.5	-0.6	-0.5	-0.8	0.4	0.6	-0.8	-0.8	0.4
Ulcerative Colitis (UC)	0.3	0.6	2.3	-0.8	-0.8	-0.6	0.5	0.3	0.3	0.8	1.2	0.4	-0.1	1.5
Major Depression (MDD)	2.6	3.2	6.6	-0.1	-2.0	1.9	-2.4	-2.2	-1.9	-0.2	-0.0	-2.6	-2.2	-1.2
Reaction Time	0.4	0.8	1.7	0.6	0.9	-1.1	1.1	1.2	1.2	-0.1	0.1	1.3	1.0	0.5
Verbal and Numeric Reasoning (VNR)	1.9	4.6	10.2	-2.5	1.3	-1.9	1.7	1.6	1.5	2.8	3.2	1.6	1.3	2.9
Breast Cancer	0.4	0.9	2.0	0.8	0.6	-1.1	1.2	1.4	1.1	-0.3	-0.6	1.2	1.2	0.1
Ovarian Cancer	0.4	0.5	1.1	0.8	0.1	-0.7	0.7	0.6	0.9	-1.1	-0.7	0.7	0.9	-0.5
Prostate Cancer	0.2	0.3	0.8	-0.5	-0.1	-0.4	0.4	0.6	0.4	0.4	0.9	0.3	0.8	0.3
Age at First Birth	0.6	0.8	3.2	1.8	-0.2	-0.3	0.4	0.1	0.3	-1.7	-1.1	0.9	-0.3	-0.6
Bipolar Disorder (2011)	1.8	1.7	2.6	-1.0	1.6	-1.4	1.4	1.6	1.2	0.9	1.3	1.3	1.5	1.0
Body Mass Index (BMI) (2010)	1.1	1.5	5.5	-2.3	-0.8	0.9	-1.0	-0.7	-1.0	1.3	1.3	-1.6	-1.2	-0.2
Coronary Artery Disease (CAD)	2.3	2.8	4.2	-1.3	1.2	-1.7	1.8	1.9	1.8	1.5	2.0	1.6	1.6	1.7
Crohns Disease (2012)	0.8	1.3	2.7	-0.7	-1.6	1.3	-1.3	-1.2	-1.5	0.2	-0.3	-1.4	-1.2	-0.5
Mean Putamen Volume	0.5	0.5	1.7	0.3	1.3	-0.7	0.8	0.9	0.8	-0.4	-0.4	0.7	0.8	-0.4
Fasting Glucose	0.4	0.4	1.4	-0.5	-1.1	0.1	-0.4	-0.3	-0.3	1.2	0.9	-0.7	-0.2	0.4
HbA1C	1.3	1.5	5.1	0.9	1.4	-0.8	2.3	0.7	1.1	-0.7	-0.5	2.2	0.3	0.8
HDL Cholesterol	0.3	0.5	1.7	0.9	-0.5	0.3	-0.3	-0.3	0.0	-1.3	-1.1	-0.0	-0.1	-1.0
LDL Cholesterol	0.2	0.3	1.0	-1.0	0.0	-0.0	-0.1	-0.1	-0.2	0.9	1.0	-0.2	-0.1	0.5
Lupus	2.2	3.3	6.9	-2.6	-1.9	1.2	-1.4	-1.1	-1.5	2.6	2.5	-2.0	-0.9	1.2
Neuroticism (2016)	0.7	1.1	3.4	-1.7	-0.7	-0.1	-0.0	-0.3	-0.0	1.8	1.9	-0.5	-0.5	1.1
Primary Biliary Cirrhosis	0.5	0.7	1.9	-1.4	-0.2	0.7	-0.6	-0.9	-0.6	0.9	1.2	-0.9	-0.7	0.3
Rheumatoid Arthritis	0.8	1.1	4.3	2.1	0.3	0.1	-0.2	-0.4	-0.0	-1.8	-1.9	0.2	-0.6	-0.9
Schizophrenia (2014)	0.1	0.2	1.2	0.3	0.2	0.3	-0.2	-0.2	-0.2	-0.8	-0.6	0.1	-1.1	0.2
Triglycerides	0.0	0.1	0.2	0.4	0.1	0.0	0.0	-0.3	0.2	-0.2	-0.2	0.0	-0.1	-0.4
Type 2 Diabetes (T2D) (2012)	0.0	0.1	0.2	0.1	-0.1	-0.3	0.2	0.2	0.3	0.1	0.5	0.1	-0.2	0.1
Ulcerative Colitis	0.4	0.6	2.0	-1.2	-0.8	-0.3	0.4	0.2	0.1	0.9	1.4	0.3	0.1	1.2
Blood Eosinophil Count	0.9	6.7	11.2	-1.4	-3.1	3.1	-3.3	-3.1	-3.0	-0.1	-0.2	-3.3	-3.3	-0.7
Blood Platelet Count	1.2	13.5	26.7	-1.5	-3.0	4.6	-4.9	-4.6	-4.9	1.0	-1.2	-5.2	-4.0	-1.5
Blood Red Count	0.8	7.4	13.5	0.3	2.9	-3.4	3.5	3.7	3.0	0.7	1.0	3.4	3.7	1.0
Blood White Count	0.0	0.2	0.8	0.6	0.1	-0.0	-0.3	0.1	-0.0	-0.9	-0.7	-0.1	-0.2	-0.2
Heel T-Score	0.8	6.0	22.5	4.7	0.7	-0.4	0.8	0.1	0.9	-4.2	-3.8	1.2	0.3	-2.9
BMI	0.3	1.6	6.6	-2.6	-1.1	0.4	-0.7	-0.3	-0.5	1.8	2.1	-1.2	-0.2	-0.1
Height	1.5	29.8	82.8	-8.8	2.9	-2.7	2.5	3.0	1.7	9.1	8.9	1.2	2.7	6.8
Waist Hip Ratio (WHR)	0.3	1.4	3.5	0.6	1.0	-1.6	1.6	1.3	1.9	0.1	0.2	1.4	1.4	0.5
Systolic Blood Pressure	0.3	1.4	4.3	-1.8	-0.3	-0.5	0.5	0.8	0.1	1.7	1.8	0.3	0.6	2.1
Smoking Status	0.4	0.9	3.0	1.6	-0.3	-0.2	0.2	-0.1	0.3	-1.7	-1.4	0.3	-0.7	-1.0
Allergy or Eczema	0.1	0.2	0.6	0.4	0.4	-0.4	0.6	0.2	0.5	0.2	-0.2	0.3	0.8	0.1
Cardiovascular Disease	0.3	0.9	2.0	-1.4	-1.0	0.7	-1.2	-0.7	-0.8	0.9	0.9	-1.3	-1.0	0.2
Hypothyroidism (self reported)	2.3	5.2	15.4	-3.9	-1.7	0.7	-1.1	-0.4	-0.9	3.7	3.8	-1.9	-0.7	1.9
Respiratory disease	0.9	2.0	4.2	-1.5	-0.8	1.4	-1.8	-1.7	-1.4	1.2	0.6	-2.0	-1.6	-0.4
Type 2 Diabetes (T2D) (2018)	1.4	2.7	8.3	-2.4	0.2	-0.6	0.8	0.9	0.4	2.9	2.8	0.1	0.8	2.3
Lung FEV1/FVC ratio	1.3	6.5	11.1	-1.1	3.3	-2.9	3.0	2.9	3.1	0.9	1.8	3.0	2.6	1.9
Lung FVC	0.2	1.1	2.2	-0.4	0.9	-1.3	0.9	1.3	1.5	0.7	0.7	1.1	1.0	1.3
Neuroticism	0.4	0.9	1.8	1.2	-0.8	1.0	-0.9	-1.2	-0.9	-0.7	-0.7	-0.9	-1.4	-0.6
Chronotype (morning person)	0.2	0.4	1.4	-0.6	0.1	0.8	-0.9	-0.3	-1.2	-0.1	-0.0	-1.0	-0.5	-0.3
Hair Pigment	0.1	1.9	4.4	0.6	2.1	-1.6	1.5	1.6	1.5	0.3	0.5	1.8	1.0	1.5
Tanning	0.1	1.4	2.8	0.6	-1.2	1.2	-1.3	-1.5	-0.9	-1.2	-1.7	-1.0	-1.3	-1.0
Hand grip strength (left)	0.4	1.2	2.8	-1.3	1.1	-1.0	0.4	1.0	1.0	1.7	1.4	-0.1	1.3	0.3
Number of treatments/medications taken	0.7	1.3	3.8	-1.9	-1.7	0.3	-0.2	0.1	-0.5	1.3	1.8	-0.4	-0.6	1.2
Average weekly spirits intake	0.4	0.5	1.2	0.0	-0.4	-1.1	0.7	0.8	0.8	0.6	0.5	0.6	0.9	0.2
Sensitivity / hurt feelings	1.9	3.3	5.1	0.7	-1.8	2.2	-1.9	-2.1	-1.9	-1.4	-1.3	-1.9	-2.2	-1.9
Frequency of depressed mood in last 2 weeks	1.8	2.5	3.8	0.3	-0.9	1.9	-1.9	-1.9	-1.8	-0.7	-0.9	-2.0	-1.9	-1.7
Hearing difficulty/problems: Yes	0.1	0.2	0.7	0.9	-0.7	0.3	-0.4	-0.2	-0.3	-0.6	-0.3	-0.1	-0.7	0.1
Relative age of first facial hair	1.1	2.2	7.4	2.7	-0.1	0.7	-0.5	-0.7	-0.6	-2.2	-2.5	-0.2	0.1	-1.8
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	4.7	-1.8	-0.9	0.4	-0.5	-0.3	-0.3	2.0	2.2	-0.7	-0.4	1.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.9	-1.2	-0.1	-0.3	0.2	0.4	-0.1	1.4	1.2	0.1	0.3	1.1
Ever had hysterectomy (womb removed)	0.4	0.5	2.2	-0.7	-0.1	0.2	-0.1	-0.3	-0.2	1.3	0.8	0.0	-0.2	1.5
Systolic blood pressure, automated reading	0.3	0.8	2.5	-1.3	-0.7	-0.2	0.3	0.4	-0.2	1.2	1.4	0.2	0.7	1.6
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	2.4	-0.8	0.8	-0.7	0.7	0.9	0.4	1.6	1.4	0.6	0.6	1.3
Angina	0.1	0.2	0.8	-0.0	-0.9	0.2	0.1	0.0	-0.4	-0.1	0.3	0.3	-0.1	0.7
Medication for hormone replacement therapy	0.5	0.6	1.4	-1.2	-0.5	0.5	-0.7	-0.4	-0.7	0.9	1.0	-0.7	-0.7	0.9
Vitamin and mineral supplements	0.1	0.2	0.9	0.3	0.3	-0.1	0.3	-0.2	0.2	-0.3	-0.3	0.2	1.0	-0.4
Supplements: Zinc	0.1	0.1	0.2	-0.3	-0.2	0.3	-0.5	-0.4	-0.2	0.4	-0.1	-0.5	-0.1	0.3
Medication: Co-codamol	0.2	0.2	0.5	-0.1	0.0	0.6	-0.5	-0.3	-0.7	-0.3	-0.6	-0.5	-0.4	-0.5
Medication: Metformin	0.6	0.9	3.3	-1.4	-0.2	-0.1	0.3	0.2	-0.0	1.6	1.8	-0.0	0.1	1.3
Diabetes (father)	0.1	0.1	0.3	-0.1	-0.5	-0.2	0.3	0.2	0.3	0.3	0.6	0.3	-0.3	0.5
Diabetes (mother)	0.3	0.3	2.3	-0.3	-1.5	0.1	-0.7	-0.0	-0.2	0.0	0.5	-0.6	-0.5	-0.2
Severe depression (siblings)	2.0	2.3	3.6	-0.5	-1.7	1.8	-1.8	-1.7	-1.8	-0.6	-0.5	-1.9	-1.7	-1.4
Pack years adult smoking proportion	0.2	0.3	0.8	-0.6	-0.7	0.3	-0.1	-0.4	-0.4	0.9	0.9	-0.4	0.0	0.2
Impedance of leg (right)	0.6	3.1	10.5	3.2	1.7	-0.6	1.1	0.4	0.5	-2.8	-2.7	1.8	0.1	-0.7
Leg fat-free mass (left)	1.1	5.8	23.8	-4.9	-0.8	0.2	-0.6	-0.1	-0.3	4.1	3.9	-1.3	0.3	2.1
Trunk fat percentage	0.1	0.5	1.7	-1.3	-1.0	-0.0	-0.1	0.0	-0.1	0.7	1.1	-0.3	0.6	-0.1
Hand grip strength (right)	1.4	3.8	9.8	-2.6	1.7	-1.4	1.0	1.5	1.3	3.1	3.0	0.4	1.5	1.9
Townsend deprivation index at recruitment	1.7	2.5	4.0	2.0	1.0	-1.7	2.0	1.8	1.5	-1.1	-1.2	1.9	1.8	-0.3
Current tobacco smoking	0.2	0.3	1.1	0.1	-1.1	0.3	-0.5	-0.7	-0.2	0.1	-0.2	-0.7	-0.7	-0.3
Average weekly fortified wine intake	0.2	0.3	0.9	-0.3	-1.0	0.1	0.0	-0.1	-0.2	0.9	0.9	-0.1	0.1	0.3
Maternal smoking around birth	0.6	0.9	1.3	1.0	-0.5	0.9	-1.0	-1.1	-1.0	-1.1	-0.8	-0.8	-1.1	-1.1
Fed-up feelings	0.5	0.8	1.7	0.8	0.1	0.9	-0.8	-1.1	-0.9	-0.8	-0.8	-0.8	-1.3	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	3.6	1.2	-1.7	1.9	-1.5	-1.9	-1.8	-1.2	-1.3	-1.4	-1.6	-1.4
Relative age voice broke	0.3	0.4	2.2	1.5	-0.2	0.1	-0.2	-0.0	-0.1	-0.8	-1.0	-0.0	-0.1	-0.7
Taking other prescription medications	0.3	0.5	2.0	-1.4	-0.9	0.5	-0.0	-0.3	-0.5	1.0	0.9	-0.2	-0.4	0.6
Age when periods started (menarche)	1.3	3.0	6.2	0.3	-0.5	2.0	-2.0	-2.3	-2.3	-1.1	-1.5	-1.8	-2.5	-1.1
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	4.4	-1.8	-0.1	0.1	0.2	-0.1	-0.5	2.0	2.1	-0.1	0.0	1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	6.8	1.8	2.0	-1.9	1.9	1.9	2.0	-1.1	-0.8	1.6	2.6	-1.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.2	-0.4	-1.1	0.8	-0.7	-0.5	-0.9	0.3	0.8	-0.9	-0.7	-0.6
Qualifications: CSEs or equivalent	0.5	0.6	2.0	1.4	0.6	-0.4	0.6	0.4	0.3	-1.1	-1.1	1.0	0.4	-0.3
Serious illness, injury or assault to yourself	0.2	0.2	0.7	0.8	0.2	-0.4	0.5	0.4	0.1	-0.3	-0.3	0.6	0.5	-0.1
High blood pressure	0.3	0.8	2.5	-1.6	-0.4	-0.3	0.0	0.4	0.1	1.6	1.6	-0.2	0.2	1.1
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.3	0.4	0.1	0.3	-0.2	-0.4	-0.2	-0.1	-0.6	-0.4	0.1	-0.1
Multivitamins +/- minerals	0.1	0.1	0.5	0.4	0.0	-0.3	-0.0	0.7	0.4	-0.2	-0.2	0.2	-0.3	0.0
Stomach or abdominal pain in last month	0.6	0.7	1.9	0.3	-1.4	1.0	-1.1	-0.8	-1.0	-0.2	-0.4	-1.1	-0.5	-0.1
Supplements: Glucosamine	1.0	1.3	4.3	-2.1	0.1	-0.5	0.1	0.6	0.3	2.0	2.1	-0.2	0.0	1.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	-0.2	-0.9	1.0	-0.9	-0.6	-1.2	0.1	-0.3	-0.9	-0.7	-0.1
Medication: Atenolol	0.2	0.2	0.5	0.1	0.3	0.4	-0.1	-0.4	-0.6	-0.7	-0.6	0.0	-0.4	-0.6
Medication: Levothyroxine sodium	2.6	4.4	13.3	-3.5	-1.4	0.1	-0.6	0.2	-0.5	3.3	3.6	-1.0	-0.5	2.9
Sitting height	1.3	9.0	21.9	-4.7	2.3	-1.9	2.0	2.1	1.5	4.6	4.4	1.3	2.0	3.5
Chronic bronchitis/emphysema (father)	0.8	0.9	4.7	2.2	-0.4	-0.3	0.6	0.0	0.4	-1.5	-1.3	0.9	-0.0	-0.5
High blood pressure (mother)	1.9	2.6	6.4	0.3	-2.5	1.9	-1.9	-1.7	-1.8	-1.0	-0.9	-1.7	-1.7	-1.1
Body mass index (BMI)	0.2	1.0	4.0	-0.8	-2.0	0.9	-1.0	-0.9	-0.8	0.2	0.5	-1.3	-0.0	-1.0
Impedance of leg (left)	0.5	2.2	7.6	2.8	1.5	-0.5	1.0	0.5	0.5	-2.3	-2.2	1.4	0.1	-0.8
Leg predicted mass (left)	1.1	5.8	24.3	-4.9	-0.9	0.3	-0.6	-0.2	-0.4	4.1	3.9	-1.4	0.3	2.1
Trunk fat mass	0.4	1.5	6.0	-2.4	-0.9	-0.1	-0.1	0.2	-0.0	1.9	2.2	-0.5	0.7	0.7
Waist circumference	0.2	0.9	2.6	-1.5	-1.2	-0.0	-0.2	-0.1	0.1	1.4	1.6	-0.7	0.7	0.1
Number of incorrect matches in round	1.8	3.0	8.0	2.8	1.2	-1.1	1.1	1.1	1.1	-2.7	-2.8	1.7	0.2	-0.8
Past tobacco smoking	0.3	0.6	2.0	-1.1	-0.3	-0.2	0.2	0.3	0.1	1.4	1.1	-0.0	1.1	0.8
Alcohol usually taken with meals	0.6	0.9	3.9	-2.0	-0.1	0.5	-0.5	-0.6	-0.7	1.3	1.3	-0.4	-0.9	0.8
Nervous feelings	2.8	5.2	11.0	3.3	-1.4	1.8	-1.7	-1.9	-1.6	-3.2	-3.2	-1.3	-2.0	-2.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.6	0.4	-0.9	0.8	-0.9	-1.1	-0.6	-0.4	-0.5	-0.8	-1.3	-0.2
Hearing difficulty/problems with background noise	0.8	1.3	2.4	-1.0	-1.4	1.0	-1.3	-0.9	-0.8	1.0	1.4	-1.6	-1.2	0.2
Hair/balding pattern: Pattern 2	2.2	2.8	8.0	2.8	-0.7	0.8	-0.8	-0.8	-0.8	-2.6	-2.8	-0.3	-1.9	-1.6
Had menopause	1.2	1.5	3.0	-1.3	-1.7	1.4	-1.3	-1.2	-1.6	1.1	0.8	-1.5	-0.7	0.0
Had other major operations	0.3	0.4	0.8	0.0	-0.9	0.4	-0.6	-0.6	-0.7	0.6	0.7	-0.5	-0.8	0.8
Forced vital capacity (FVC)	2.7	10.4	17.0	-3.7	3.5	-3.0	2.5	2.8	2.7	4.1	4.1	2.2	2.3	3.9
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	6.8	2.1	1.9	-2.0	2.4	2.1	2.3	-1.7	-1.0	2.2	2.6	-1.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.9	1.7	-1.2	0.5	-0.7	-0.8	-0.3	-1.5	-0.9	-0.6	-1.0	-1.3
Qualifications: None of the above	0.4	0.8	1.2	1.0	0.3	-0.8	0.9	0.8	0.9	-1.0	-1.1	1.1	1.1	0.1
Financial difficulties in last 2 years	1.2	1.7	3.3	1.8	1.7	-1.4	1.2	1.0	1.6	-1.1	-1.2	1.5	0.4	-0.4
Mouth/teeth dental problems	0.4	0.6	1.7	0.8	1.1	-0.3	0.2	0.2	0.5	-0.8	-1.3	0.2	0.4	-1.1
Heart attack	0.8	1.0	2.3	0.7	-1.5	1.0	-0.9	-1.2	-1.2	-0.9	-0.4	-0.7	-1.3	-0.4
Allergy	0.5	1.1	1.8	-0.4	0.9	-1.1	1.3	1.2	1.0	0.4	1.0	1.3	1.1	0.8
Pain all over the body in last month	0.2	0.2	0.8	0.5	-0.1	-0.0	0.4	0.1	0.4	-0.4	-0.6	0.3	0.9	-0.3
Diabetes (self-reported)	0.9	1.4	4.4	-1.5	0.7	-0.5	0.7	0.8	0.5	2.1	2.0	0.1	0.7	1.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	0.6	0.4	-0.1	0.3	0.3	0.1	-0.5	-0.2	0.4	-0.2	0.2
Medication: Ramipril	0.1	0.2	0.8	0.5	-0.9	-0.1	-0.0	-0.1	0.2	-0.5	-0.1	0.3	-0.7	0.3
Medication: Simvastatin	0.9	1.3	4.3	-1.9	-0.8	-0.0	-0.4	-0.0	-0.4	2.1	2.0	-0.6	-0.0	1.1
Fluid intelligence score	0.6	1.3	4.2	-2.0	0.4	-0.3	0.4	0.3	-0.1	1.9	2.0	0.2	0.1	1.4
Illnesses of siblings	0.1	0.2	0.7	-0.3	0.3	-0.5	0.4	0.3	0.5	0.3	0.1	0.3	0.8	-0.2
Neuroticism score	1.2	2.5	3.7	1.4	-0.9	1.6	-1.6	-1.8	-1.4	-1.4	-1.5	-1.7	-1.9	-1.9
Weight	0.7	3.5	13.3	-3.6	-1.3	0.4	-0.7	-0.4	-0.6	3.1	3.1	-1.3	0.3	1.2
Impedance of arm (right)	0.2	0.9	2.4	0.8	1.6	-0.9	1.0	0.6	0.8	-0.9	-0.9	1.3	0.4	0.3
Arm fat percentage (right)	0.1	0.3	1.0	-0.5	-1.0	0.1	-0.2	-0.1	-0.0	0.1	0.4	-0.4	0.8	-0.8
Trunk fat-free mass	1.0	5.8	20.3	-4.5	-0.5	0.0	-0.4	-0.0	-0.3	4.3	4.0	-1.0	0.1	2.6
Hip circumference	0.4	1.7	5.5	-2.4	-1.4	0.6	-0.8	-0.6	-0.7	1.9	2.0	-1.2	0.2	0.2
Time employed in main current job	0.6	0.7	1.3	-1.0	-1.1	0.8	-0.9	-0.9	-1.1	0.1	0.3	-1.0	-0.8	-0.6
Alcohol intake versus 10 years previously	0.4	0.6	1.8	1.2	-0.4	0.8	-0.6	-0.6	-0.8	-1.3	-0.7	-0.3	-0.7	-0.6
Father’s age at death	0.7	1.0	2.8	-0.1	1.7	-1.0	1.0	1.1	1.3	0.5	0.3	1.0	0.7	1.0
Worrier / anxious feelings	0.6	1.1	3.4	-1.8	-0.6	0.9	-1.1	-0.6	-1.2	1.0	1.0	-1.3	-0.9	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.9	0.3	-1.7	1.0	-1.0	-1.1	-0.9	-0.2	-0.2	-1.0	-1.2	-0.2
Falls in the last year	0.3	0.4	1.0	0.4	-0.7	0.7	-0.7	-0.7	-0.6	-0.5	-0.4	-0.5	-1.0	-0.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.4	0.1	0.3	0.3	-0.6	-0.3	-0.1	0.2	-0.1	-0.6	-0.3	-0.3
Number of live births	2.1	2.9	5.0	1.0	-1.4	1.7	-2.1	-1.7	-1.7	-1.5	-1.9	-1.9	-1.4	-2.2
Forced expiratory volume in 1-second (FEV1)	3.7	12.6	21.6	-4.4	3.6	-3.2	2.6	3.0	2.9	4.5	4.6	2.3	2.6	4.4
Pulse rate	0.0	0.0	0.1	-0.0	-0.3	-0.3	-0.1	0.1	0.1	0.0	0.0	-0.2	0.3	-0.4
Happiness	1.0	1.3	2.9	1.2	-1.2	0.7	-1.3	-1.0	-0.6	-1.4	-1.2	-1.0	-1.7	-0.5
Noisy workplace	1.0	1.2	2.5	0.6	1.3	-1.3	1.3	1.6	1.3	0.1	0.4	1.3	1.1	0.7
Qualifications: A levels/AS levels or equivalent	0.9	2.0	5.9	-2.2	1.5	-1.1	0.6	1.0	0.9	1.9	2.4	0.2	0.2	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.0	1.0	-0.3	0.5	-0.4	-0.7	-0.7	-0.3	-0.3	-0.3	-0.2	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.5	3.1	0.6	-1.8	0.4	-0.5	-0.7	-0.6	-0.6	-0.3	-0.2	-0.5	-0.1
Asthma	1.0	1.9	5.0	-1.1	-1.0	1.5	-2.0	-1.6	-1.2	0.9	0.5	-2.2	-1.4	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.6	-0.2	-0.7	0.3	-0.1	-0.3	-0.3	-0.2	0.0	-0.2	0.1	-0.0
Medication: Cholesterol lowering	0.4	0.6	1.5	-1.2	-1.1	0.2	-0.4	-0.2	-0.6	0.8	1.1	-0.3	-0.3	1.2
Depression (self-reported)	0.3	0.4	1.1	0.5	-0.2	0.4	-0.7	-0.8	-0.2	0.1	-0.2	-1.1	-0.6	-0.8
Medication: Lansoprazole	4.0	4.6	8.5	-2.5	1.1	-2.1	1.8	2.1	1.9	2.3	2.9	1.7	2.0	2.5
Prospective memory result	0.2	0.3	0.7	0.8	-0.5	-0.2	0.4	0.0	0.3	-0.5	-0.6	0.6	0.9	0.0
Lung cancer (father)	1.1	1.3	2.2	-0.8	0.6	-1.5	1.5	1.1	1.3	0.5	1.1	1.4	1.3	1.2
Illnesses of mother	1.1	1.4	2.2	-0.2	1.5	-1.4	1.3	0.9	1.3	1.2	1.1	1.1	1.0	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	3.4	10.8	15.0	-3.6	3.8	-3.0	2.8	3.1	2.9	3.7	3.9	2.6	2.6	3.7
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	0.0	-0.5	0.4	-0.5	-0.6	-0.8	0.5	0.8	-0.6	-0.9	0.4
Impedance of arm (left)	0.2	0.8	2.5	0.1	1.6	-1.0	1.1	0.8	0.9	-0.2	-0.2	1.3	0.5	0.7
Arm fat mass (right)	0.3	1.1	3.4	-1.9	-1.5	0.5	-0.7	-0.5	-0.6	1.2	1.4	-1.1	0.3	-0.3
Trunk predicted mass	1.0	5.8	20.4	-4.5	-0.5	0.1	-0.4	-0.0	-0.3	4.3	4.1	-1.0	0.1	2.6
Standing height	1.4	13.9	43.6	-6.6	1.4	-1.1	0.8	1.1	0.6	6.5	6.0	0.0	0.9	5.0
Length of working week for main job	0.9	1.0	2.3	0.4	-1.4	0.9	-1.5	-1.0	-0.9	-0.7	-0.6	-1.2	-1.4	-0.5
Exposure to tobacco smoke at home	0.1	0.1	0.4	-0.0	-0.4	0.5	0.1	-0.3	-0.7	0.0	0.2	-0.1	0.1	0.1
Breastfed as a baby	1.1	1.4	3.3	-0.7	1.2	-1.2	1.1	1.0	1.1	1.3	1.0	0.9	1.1	1.8
Tense / ‘highly strung’	1.3	2.2	4.5	2.0	-1.5	0.9	-1.4	-1.2	-1.0	-2.0	-2.1	-1.1	-1.3	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.5	3.9	4.8	1.5	-2.1	2.0	-2.1	-2.2	-1.9	-1.3	-2.2	-2.1	-2.1	-1.8
Hair/balding pattern: Pattern 4	1.4	3.5	8.7	-2.1	1.0	-1.5	1.3	1.4	1.2	2.5	3.0	1.1	1.7	2.5
Birth weight of first child	0.6	1.2	2.2	-0.2	0.5	-1.3	1.2	1.3	1.3	0.6	1.3	1.2	0.5	1.5
Peak expiratory flow (PEF)	4.9	11.3	22.8	-4.7	3.4	-2.6	2.1	2.6	2.2	4.5	4.8	1.7	2.4	4.0
Pulse wave reflection index	0.2	0.3	1.4	0.3	0.0	0.5	-0.5	-0.7	-0.3	-0.2	0.1	-0.5	-1.2	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	-0.2	-0.4	-0.2	0.2	-0.0	0.3	0.1	0.4	0.4	-0.0	0.6
Loud music exposure frequency	0.1	0.1	0.4	0.1	-0.4	0.3	-0.3	-0.3	-0.3	-0.3	0.4	-0.3	-0.6	0.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.6	-0.2	1.2	-0.8	0.5	0.6	0.6	0.5	0.3	0.5	0.6	0.6
Mouth/teeth dental problems: Bleeding gums	1.7	2.1	3.9	0.0	-1.5	1.8	-1.8	-1.7	-1.8	-0.3	-0.4	-1.9	-2.0	-1.1
Blood clot in the leg (DVT)	0.2	0.3	1.1	0.6	-0.3	0.1	-0.3	-0.2	-0.2	-1.1	-0.5	0.2	-0.8	-0.5
Medication: Paracetamol	0.3	0.5	0.9	0.5	-0.8	0.9	-0.8	-0.8	-0.9	-0.6	-0.5	-0.8	-0.6	-0.9
Headache pain in last month	0.3	0.5	1.2	-0.1	-0.3	0.9	-0.9	-0.8	-1.0	-0.3	-0.3	-0.8	-1.1	-0.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	2.4	0.0	1.6	-0.6	0.6	0.4	0.8	0.2	-0.1	0.6	0.6	0.2
Glaucoma (self-reported)	0.2	0.3	0.6	0.5	-0.7	0.7	-0.5	-0.5	-0.6	-0.5	-0.8	-0.4	-0.1	-0.2
Gout (self-reported)	0.2	0.3	1.3	-0.8	-0.1	0.0	0.5	0.3	-0.1	0.6	1.1	0.3	0.6	0.4
Hypothyroidism/myxoedema (self-reported)	1.8	3.6	11.0	-3.0	-1.1	-0.1	-0.3	0.4	-0.1	3.3	3.3	-0.9	-0.2	2.5
Medication: Amlodipine	1.5	2.2	6.0	-0.7	-2.5	1.7	-1.8	-1.4	-2.0	0.0	-0.1	-2.0	-1.1	-0.6
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.9	-0.5	-0.6	1.8	-1.9	-1.6	-1.6	-0.1	-0.6	-2.0	-1.3	-1.3
Birth weight	2.5	5.4	8.9	-2.9	1.9	-2.2	2.0	2.2	2.1	2.9	3.0	1.6	1.7	2.5
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.0	-0.9	1.0	-0.2	0.5	0.4	-0.0	0.8	1.0	0.4	-0.3	0.7
High blood pressure (siblings)	0.4	0.6	1.6	0.9	-0.3	0.9	-0.6	-0.8	-0.7	-1.2	-0.8	-0.3	-1.3	-0.4
Forced vital capacity (FVC), Best measure	1.8	6.5	10.0	-3.2	3.0	-2.2	2.0	2.2	2.2	3.1	3.2	1.8	1.7	2.9
Body fat percentage	0.1	0.2	1.1	-0.2	-1.1	0.1	-0.1	-0.1	-0.1	-0.1	0.2	-0.3	0.7	-0.8
Leg fat percentage (right)	0.2	0.9	2.5	1.4	-1.0	0.3	-0.0	-0.2	-0.2	-1.5	-1.3	0.1	0.7	-1.6
Arm fat-free mass (right)	1.0	5.0	17.9	-4.2	-1.0	0.3	-0.6	-0.1	-0.4	3.9	3.8	-1.2	0.2	2.1
Exposure to tobacco smoke outside home	1.6	2.2	9.5	3.1	-0.7	-0.3	0.4	0.1	0.4	-2.3	-2.4	0.7	1.0	-1.0
Comparative body size at age 10	0.5	1.5	3.1	-0.1	-1.8	1.5	-1.6	-1.5	-1.3	-0.1	-0.5	-1.5	-1.5	-0.5
Number of full brothers	0.4	0.5	2.1	0.5	0.3	0.7	-0.9	-0.8	-0.7	-0.3	-1.4	-0.6	-0.7	-0.5
Worry too long after embarrassment	0.4	0.6	1.3	0.3	-0.5	0.9	-1.0	-0.9	-0.7	-0.4	-0.5	-1.1	-0.8	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.5	0.6	-0.7	0.5	-1.0	-0.9	-0.5	-0.4	-1.0	-1.0	-1.2	-0.5
Wheeze or whistling in the chest in last year	0.3	0.5	2.1	0.3	-1.4	0.7	-0.7	-0.9	-0.5	-0.1	-0.0	-0.8	-0.8	-0.2
Number of children fathered	0.4	0.4	1.7	-0.2	1.3	-0.5	0.4	0.8	0.5	0.6	0.4	0.5	0.7	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.0	-0.5	-0.7	1.2	-1.3	-1.4	-1.1	-0.5	-0.5	-1.0	-2.0	-0.4
Age at first live birth	0.2	0.3	1.4	-0.0	1.2	-0.5	0.5	0.6	0.5	0.3	0.2	0.4	0.5	-0.0
Pulse wave peak to peak time	0.3	0.3	0.7	-0.4	0.6	-0.5	0.6	0.7	0.8	-0.1	-0.4	0.6	0.9	-0.1
Health satisfaction	0.0	0.1	0.2	0.3	0.2	-0.2	0.4	-0.0	0.0	0.0	0.4	0.1	0.2	0.2
Shortness of breath walking on level ground	0.3	0.3	1.6	-0.6	-0.5	-0.1	0.1	-0.1	0.0	0.8	1.2	-0.1	-0.0	0.7
Qualifications: College or University degree	1.2	3.8	15.4	-3.9	-0.8	0.8	-1.3	-0.9	-0.9	2.5	3.0	-1.8	-1.6	1.1
Eye problems/disorders: None of the above	0.2	0.3	1.0	0.3	0.8	-0.5	0.2	0.4	0.3	-0.1	-0.6	-0.1	1.0	-0.6
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	-0.5	-0.9	0.5	-0.4	-0.8	-0.8	0.4	0.9	-0.5	-0.4	0.0
Emphysema/chronic bronchitis	0.2	0.2	0.9	-0.9	-0.1	-0.0	-0.1	0.4	0.1	0.9	0.6	-0.2	-0.1	0.6
Medication for pain relief, constipation, heartburn	0.3	0.5	2.1	-0.9	1.4	-0.4	-0.0	0.0	0.3	1.3	0.4	-0.2	-0.2	0.6
Neck or shoulder pain in last month	0.1	0.2	0.7	-0.6	-0.2	-0.3	0.1	0.3	0.5	0.1	0.9	0.1	-0.6	0.4
Medication: Blood pressure	0.1	0.1	0.6	-0.4	-0.8	0.2	-0.1	-0.1	-0.4	0.2	0.6	-0.1	-0.3	-0.2
Angina (self-reported)	0.1	0.2	1.2	0.3	-1.1	0.3	-0.1	-0.2	-0.5	-0.4	-0.1	0.2	-0.4	0.5
Migraine (self-reported)	0.3	0.3	1.1	-0.5	0.5	-0.6	0.5	0.6	0.5	0.6	1.1	0.4	0.1	0.6
Medication: Ibuprofen	0.3	0.3	0.6	-0.4	-0.1	-0.5	0.7	0.5	0.5	0.4	0.6	0.6	0.8	0.7
Medication: Allopurinol	0.4	0.5	1.5	-0.5	0.0	-0.3	0.8	0.7	0.1	0.4	0.9	0.8	1.2	0.8
Medication: Omeprazole	0.6	0.7	2.6	-0.9	-1.6	0.9	-0.7	-0.7	-1.0	0.5	0.8	-1.0	-0.3	0.1
Medication: Seretide 50 evohaler	0.8	0.9	2.2	-0.1	-1.1	1.2	-1.3	-1.0	-1.1	0.6	0.0	-1.5	-0.7	-0.4
Mean time to correctly identify matches	0.2	0.5	1.3	0.4	0.0	-0.8	0.8	0.9	0.8	-0.1	0.3	1.1	0.6	0.6
Heart disease (mother)	0.4	0.5	1.4	0.4	-1.2	0.7	-0.6	-0.5	-0.7	-1.2	-0.9	-0.3	0.1	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.8	-0.9	-0.0	0.1	-0.2	-0.1	-0.3	0.7	0.8	-0.4	-0.4	0.5
Whole body fat mass	0.2	0.8	2.9	-1.7	-1.2	0.2	-0.4	-0.2	-0.4	1.3	1.4	-0.8	0.6	0.0
Leg fat mass (right)	0.1	0.4	1.7	-0.7	-1.3	0.5	-0.5	-0.4	-0.5	0.4	0.5	-0.7	0.5	-0.6
Arm predicted mass (right)	0.9	4.6	17.0	-4.1	-0.9	0.3	-0.6	-0.1	-0.5	3.7	3.7	-1.3	0.1	1.9
Pulse rate, automated reading	0.7	2.2	6.0	-0.4	-2.5	1.7	-1.9	-1.6	-1.6	-0.0	-0.2	-1.9	-1.3	-0.7
Alcohol intake frequency.	0.2	0.5	1.0	0.1	-0.7	0.8	-1.0	-0.7	-0.9	0.1	-0.2	-1.0	-0.9	0.0
Comparative height size at age 10	1.2	6.8	18.6	-4.2	1.3	-1.3	1.3	1.3	1.0	4.3	4.3	0.7	1.7	3.0
Number of full sisters	0.1	0.1	0.7	-0.0	0.3	-0.2	0.1	0.2	0.2	-0.5	-0.5	0.1	0.3	-0.8
Suffer from ‘nerves’	4.7	7.4	12.3	3.1	-1.6	2.5	-2.6	-2.9	-2.5	-3.1	-3.5	-2.2	-2.8	-2.7
Overall health rating	0.9	1.9	3.8	-0.5	-1.9	1.7	-1.4	-1.7	-1.7	-0.1	-0.2	-1.7	-1.3	-1.0
Chest pain or discomfort	0.7	1.0	1.4	1.1	-1.0	1.0	-0.8	-1.1	-0.7	-1.1	-1.1	-0.6	-1.2	-0.9
Had major operations	1.3	1.5	5.0	-0.8	-2.2	1.2	-1.3	-1.1	-1.3	0.4	0.6	-1.6	-1.2	-0.6
Age at last live birth	0.1	0.1	0.3	0.4	0.4	-0.0	-0.1	-0.2	0.2	-0.6	-0.4	0.1	-0.0	-0.4
Family relationship satisfaction	0.3	0.4	1.4	1.2	0.4	-0.6	0.7	0.5	0.9	-0.5	-0.4	0.6	0.5	0.0
Leg pain on walking	0.3	0.4	0.8	-0.7	-0.4	0.7	-0.6	-0.7	-0.6	0.3	0.4	-0.7	-0.9	0.2
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	3.2	1.2	0.9	-1.6	1.7	1.4	1.6	-0.6	-0.4	1.8	1.4	0.0
Commuting to job workplace: Car/motor vehicle	1.3	1.5	4.7	1.0	-0.5	1.1	-1.0	-1.0	-1.1	-1.4	-1.7	-1.0	-0.6	-2.2
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	3.5	-1.2	-1.6	1.3	-1.4	-1.1	-1.1	0.3	0.3	-1.9	-0.7	-1.0
Medication: Aspirin	0.5	0.6	2.8	0.9	-1.7	0.2	0.0	-0.1	-0.5	-1.6	-0.4	0.4	0.1	-0.6
Supplements: Vitamin C	0.1	0.1	0.4	0.4	0.7	-0.2	0.2	0.2	0.4	-0.3	-0.4	0.4	-0.3	0.2
Knee pain experienced in last month	0.3	0.4	0.8	-0.9	-0.7	0.4	-0.8	-0.3	-0.5	0.1	0.4	-0.6	-0.8	0.9
Hypertension (Self-reported)	0.4	1.1	3.1	-1.8	-0.8	0.5	-0.7	-0.4	-0.7	1.5	1.5	-0.9	-0.6	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.6	-1.1	-0.3	0.2	0.1	-0.3	-0.1	1.2	1.2	-0.2	0.4	0.4
Illnesses of father: Heart disease	0.2	0.2	0.6	0.4	0.3	-0.5	0.8	0.4	0.4	-0.0	0.1	0.7	0.7	0.0
Illnesses of siblings: Diabetes	0.5	0.6	2.0	-0.7	0.1	-0.6	0.6	0.4	0.4	1.3	1.0	0.4	0.5	1.4
Smoking status: Previous	0.4	0.6	2.5	1.0	0.2	0.3	-0.1	-0.3	-0.2	-1.6	-1.2	0.2	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.0	-2.0	1.0	-0.5	0.4	0.6	0.6	1.8	1.8	-0.1	0.7	1.3
Whole body fat-free mass	1.1	6.2	23.2	-4.8	-0.9	0.3	-0.6	-0.2	-0.4	4.3	4.1	-1.3	0.1	2.4
Leg fat-free mass (right)	1.3	7.0	28.4	-5.3	-1.1	0.4	-0.8	-0.2	-0.5	4.6	4.3	-1.6	0.2	2.2
Arm fat percentage (left)	0.1	0.3	1.2	-0.7	-1.1	0.1	-0.2	-0.1	-0.1	0.3	0.5	-0.5	0.7	-0.7
Average weekly red wine intake	0.1	0.2	0.9	-0.5	0.2	0.1	-0.6	-0.3	-0.0	0.0	-0.1	-0.3	-0.9	-0.2
Handedness (chirality/laterality): Left-handed	1.6	1.9	6.6	1.8	-0.7	0.7	-0.7	-0.8	-0.6	-2.6	-2.2	-0.4	-0.5	-1.8
Mood swings	1.8	3.2	4.4	1.6	-1.6	1.8	-1.7	-1.9	-1.4	-1.8	-2.0	-1.7	-2.1	-2.1
Loneliness, isolation	2.2	3.0	6.0	0.5	-1.0	2.0	-2.2	-2.1	-2.1	-0.6	-0.8	-2.1	-2.4	-1.6
Long-standing illness, disability or infirmity	1.8	2.7	6.7	-2.5	-2.0	0.9	-0.8	-0.7	-1.0	2.3	2.6	-1.3	-0.6	1.5
Ever had bowel cancer screening	0.8	1.0	3.4	0.5	-1.9	1.0	-1.1	-1.3	-1.2	-0.2	0.1	-1.1	-0.9	-0.1
Diabetes diagnosed by doctor	0.6	0.9	3.8	-1.1	0.1	-0.3	0.5	0.4	0.1	1.9	1.7	0.0	0.5	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	0.9	0.5	-0.4	-0.0	0.1	0.1	-0.5	-0.6	0.1	0.4	0.1
Friendships satisfaction	1.5	1.8	3.9	0.7	1.4	-2.0	1.6	1.6	2.0	-0.0	0.4	1.7	1.0	0.8
Qualifications: nursing, teaching	0.7	1.1	3.7	-1.3	0.7	-0.5	0.6	0.8	0.3	1.6	1.9	0.4	0.3	1.6
Commuting to job workplace: Walk	1.8	1.9	7.7	-1.8	-0.3	-0.5	0.7	0.3	0.5	2.1	2.0	0.6	0.5	2.8
Eye problems/disorders: Cataract	0.2	0.3	1.1	0.6	0.4	-0.4	0.6	0.0	0.3	-0.8	-0.5	1.1	-0.0	0.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.7	-1.0	1.5	-0.9	0.9	1.1	0.6	1.3	1.5	1.0	0.8	1.7
Medication for cholesterol	1.0	1.4	4.3	2.1	1.1	-0.1	0.6	0.2	0.4	-1.9	-1.8	0.7	0.7	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.2	-0.5	0.2	-1.3	1.3	1.0	1.3	0.8	0.8	1.6	0.8	1.8
Back pain experienced in last month	1.3	1.9	3.5	-1.0	-1.9	1.6	-1.6	-1.6	-1.8	0.1	0.2	-1.5	-1.9	0.1
Mineral and other dietary supplements	0.4	0.5	1.1	1.0	0.9	-0.4	0.7	0.2	0.5	-1.0	-0.6	0.8	0.8	-0.6
Breast cancer (self-reported)	1.2	1.5	3.5	-0.3	-1.3	1.7	-1.3	-1.6	-1.9	0.1	0.4	-1.4	-1.4	-0.3
Asthma (self-reported)	1.1	2.2	5.9	-1.0	-1.1	1.7	-2.2	-1.7	-1.4	0.7	0.2	-2.4	-1.5	-1.0
Osteoporosis (self-reported)	0.1	0.1	0.4	-0.7	-0.0	-0.1	0.1	0.3	0.3	0.2	-0.2	0.3	-0.2	0.5
Osteoarthritis (self-reported)	1.1	1.4	2.7	-0.8	0.5	-1.3	0.7	1.3	1.1	1.5	1.5	0.7	1.5	1.6
Medication: Aspirin	0.3	0.4	2.4	0.4	-1.5	0.3	-0.2	-0.2	-0.6	-1.0	-0.2	0.1	-0.1	-0.4
Medication: Gliclazide	1.1	1.3	2.6	-1.5	-1.3	1.1	-1.3	-1.0	-1.1	1.2	0.6	-1.6	-0.7	-0.3
Illnesses of father: None of the above (group 1)	0.7	0.9	2.3	0.3	-0.6	1.0	-1.0	-0.8	-0.8	-1.0	-1.4	-1.0	-0.3	-1.5
Smoking status: Current	0.2	0.3	0.8	0.1	-0.9	0.4	-0.6	-0.8	-0.4	0.2	-0.2	-0.8	-0.8	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.4	7.2	12.0	0.4	3.1	-3.1	3.3	2.9	3.4	0.3	0.9	3.5	3.5	1.8
Whole body water mass	1.1	6.3	23.8	-4.9	-0.8	0.3	-0.6	-0.2	-0.4	4.4	4.2	-1.4	0.1	2.4
Leg predicted mass (right)	1.3	6.9	27.9	-5.3	-1.1	0.4	-0.9	-0.3	-0.5	4.5	4.2	-1.7	0.1	2.2
Arm fat mass (left)	0.3	1.1	3.1	-1.8	-1.6	0.6	-0.7	-0.5	-0.6	1.2	1.4	-1.1	0.3	-0.2
Number of self-reported non-cancer illnesses	0.9	1.6	4.4	-2.0	-1.3	0.2	-0.5	-0.1	-0.3	1.9	2.1	-0.8	-0.7	1.3
Average weekly champagne plus white wine intake	1.6	2.1	8.0	-2.8	-0.6	0.9	-1.3	-0.9	-1.1	2.2	1.5	-1.7	-0.7	0.6
Miserableness	0.2	0.3	0.7	0.1	0.4	0.5	-0.6	-0.8	-0.4	0.2	0.1	-0.8	-0.6	-0.6
Guilty feelings	0.4	0.6	1.7	-0.1	-0.2	0.7	-1.1	-0.8	-0.9	0.3	-0.0	-1.3	-1.0	-0.5
Wears glasses or contact lenses	1.3	1.5	2.5	0.3	-1.3	1.5	-1.6	-1.5	-1.4	-0.5	-1.3	-1.4	-1.4	-0.6
Ever taken oral contraceptive pill	0.5	0.5	0.9	0.9	-0.3	0.6	-0.8	-0.6	-0.5	-0.9	-0.8	-0.8	-0.7	-0.9
Hearing aid user	0.1	0.1	0.3	0.3	0.3	0.4	-0.2	-0.4	-0.4	-0.1	-0.5	-0.3	0.0	-0.6
Mother’s age at death	1.5	1.8	4.2	-1.8	1.2	-1.1	0.8	0.9	0.8	2.0	1.8	0.8	1.0	1.7
Financial situation satisfaction	1.6	2.0	7.3	2.7	0.3	1.0	-0.7	-1.0	-0.5	-2.0	-2.4	-0.4	-0.4	-1.4
Tinnitus: Yes, now most or all of the time	1.5	1.8	2.7	-0.8	1.5	-1.6	1.1	1.6	1.3	1.1	1.3	1.1	1.3	1.6
Commuting to job workplace: Public transport	0.3	0.3	0.9	-0.9	-0.3	-0.1	-0.4	0.1	0.1	0.7	0.9	-0.4	-0.3	0.8
Eye problems/disorders: Glaucoma	0.8	1.0	2.9	0.1	-1.7	1.3	-1.1	-1.1	-1.2	0.0	-0.3	-1.2	-0.8	-0.2
Medication: Blood pressure	0.7	1.3	4.4	-2.1	-0.3	-0.0	-0.1	0.1	-0.2	2.1	1.7	-0.3	-0.2	1.6
Pain type(s) experienced in last month: Hip pain	1.8	2.3	7.6	-2.8	-0.6	0.3	-0.7	-0.3	-0.4	2.2	2.5	-0.9	-1.4	1.7
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.7	0.1	0.2	-0.5	0.6	0.9	0.6	0.3	0.1	0.6	0.3	0.6
High cholesterol (Self-reported)	0.2	0.3	1.0	-0.6	-1.0	-0.2	-0.0	0.4	-0.3	0.6	0.8	0.1	0.3	0.8
Medication: Bendroflumethiazide	0.5	0.7	1.8	-0.5	-1.3	0.9	-1.0	-0.9	-0.9	0.4	0.1	-1.0	-1.1	-0.1
Medication: Paracetamol	0.2	0.3	1.2	-1.1	-0.4	0.0	-0.2	0.0	-0.0	0.8	1.1	-0.2	-0.3	0.4
Medication: Lisinopril	1.2	1.6	2.9	-1.6	-0.5	1.1	-1.2	-1.0	-1.4	1.4	1.4	-1.3	-1.7	0.6
Medication: Atorvastatin	0.2	0.3	1.2	-0.0	-1.1	0.4	-0.3	-0.5	-0.6	-0.2	0.3	-0.2	-0.3	0.7
Illnesses of father: High blood pressure	2.3	2.9	7.5	-0.1	-0.6	2.1	-2.2	-2.0	-2.3	-0.3	-0.5	-2.1	-2.7	-0.8
Alcohol drinker status: Never	2.4	2.8	4.9	-1.6	-2.2	1.5	-2.2	-1.8	-1.8	1.1	0.5	-2.2	-1.9	0.5
Ever smoked	0.3	0.5	1.2	0.9	-0.3	0.4	-0.5	-0.7	-0.2	-1.1	-0.9	-0.4	-1.0	-0.8
Basal metabolic rate	1.0	5.5	21.2	-4.6	-1.0	0.4	-0.7	-0.4	-0.6	4.0	3.8	-1.4	0.1	2.0
Leg fat percentage (left)	0.2	0.8	2.7	1.1	-1.2	0.4	-0.2	-0.3	-0.3	-1.1	-1.0	-0.3	0.6	-1.7
Arm fat-free mass (left)	0.7	3.6	12.9	-3.6	-1.1	0.5	-0.6	-0.4	-0.6	3.2	3.2	-1.2	0.1	1.5
Number of operations (self-reported)	0.8	1.2	3.5	-0.5	-1.3	0.2	-0.5	-0.4	-0.8	1.8	1.9	-0.6	-0.7	1.6
Average weekly beer plus cider intake	1.2	1.7	2.3	-1.3	1.2	-1.2	1.2	1.4	1.4	1.5	1.5	0.8	1.3	1.5
Irritability	0.5	0.9	3.1	-1.7	-0.7	-0.2	-0.5	-0.1	0.1	1.7	1.3	-0.9	-0.4	0.9
Risk taking	0.2	0.4	1.4	-0.7	0.7	-0.5	0.0	0.4	0.4	1.2	0.3	0.1	-0.1	0.9
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.5	-0.8	0.4	-0.7	0.2	0.5	0.6	1.2	1.0	0.2	0.4	1.2
Fractured/broken bones in last 5 years	1.8	2.3	4.0	-2.0	-1.8	1.4	-1.6	-1.3	-1.8	1.6	1.2	-2.0	-1.1	0.1
Age started oral contraceptive pill	0.4	0.4	1.4	-1.1	-0.8	0.2	-0.0	0.1	-0.2	0.9	1.2	-0.1	0.4	0.8
Diastolic blood pressure, automated reading	0.1	0.3	1.2	0.6	0.0	-0.4	0.6	0.5	0.3	-0.4	-0.2	0.6	1.1	-0.1
Ever depressed for a whole week	2.2	2.7	4.9	1.2	-2.0	1.5	-2.0	-1.9	-1.4	-1.4	-1.3	-1.7	-2.2	-0.8
Unable to work because of sickness or disability	0.7	0.9	2.1	0.1	0.9	-1.2	1.2	1.1	1.4	0.3	0.2	1.1	1.4	0.2
Commuting to job workplace: Cycle	0.2	0.3	1.1	-0.5	1.0	-0.4	0.5	0.1	0.7	0.1	0.1	0.6	0.2	0.5
Myopia	0.9	1.2	2.8	-0.1	-0.8	1.2	-1.5	-1.0	-1.4	-0.3	-1.0	-1.7	-1.4	-0.8
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.7	1.6	0.7	0.4	-0.1	-0.4	-0.2	-1.5	-1.6	0.0	-0.2	-1.3
Cholesterol lowering medication	0.5	0.8	2.7	-1.4	-0.8	0.1	-0.6	-0.1	-0.4	1.6	1.3	-0.7	-0.2	0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.0	-0.3	-1.0	0.0	0.1	0.2	-0.0	0.1	0.7	-0.0	0.4	0.5
Pain experienced in last month	1.0	1.6	3.3	1.8	1.7	-1.1	1.4	0.9	1.2	-0.7	-0.9	1.5	1.4	-0.5
Supplements: Calcium	0.5	0.6	1.5	-0.5	-1.2	0.8	-0.8	-0.9	-0.9	0.2	-0.3	-0.8	-0.8	-0.3
Basal cell carcinoma (self-reported)	1.0	1.2	2.6	-1.0	1.6	-0.7	0.8	0.7	0.6	1.6	1.6	0.6	0.1	1.6
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.7	0.8	-1.6	1.1	-1.0	-1.4	-1.3	-1.0	-0.5	-0.8	-1.3	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.5	0.7	-0.7	0.4	-0.6	-0.5	-0.5	-1.2	-0.7	-0.2	-0.9	-0.8
Heart disease (siblings)	0.4	0.5	1.5	-1.2	0.4	-0.3	0.1	0.3	0.1	1.2	1.1	0.0	-0.0	1.2
Alcohol drinker status: Previous	0.2	0.3	1.2	0.4	0.4	-0.4	0.4	0.4	0.4	-0.1	0.2	0.7	-0.0	1.1
Pack years of smoking	0.3	0.4	1.1	-0.7	-0.8	0.3	-0.2	-0.4	-0.5	1.0	1.0	-0.4	-0.0	0.4
Impedance of whole body	0.2	1.3	2.8	1.4	1.7	-0.8	1.1	0.7	0.8	-1.4	-1.2	1.5	0.4	0.0
Leg fat mass (left)	0.2	0.6	2.2	-0.9	-1.5	0.6	-0.6	-0.4	-0.6	0.6	0.7	-0.9	0.4	-0.6
Arm predicted mass (left)	0.7	3.3	11.8	-3.4	-0.9	0.3	-0.5	-0.2	-0.4	3.1	3.2	-1.0	0.2	1.6