Hub : Genes

GGTA1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Esophageal Carcinoma 0.565 0.1510 0.00025 0.057 0.117 0.196 NA 0.059 0.0067 0.00015 7.4e-07 NA 0.0061
2 TCGA Kidney Renal Clear Cell Carcinoma 0.092 0.0482 0.00290 0.016 0.023 0.032 NA 0.025 0.0054 0.00100 1.5e-04 NA 0.0007

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.2 0.4 0.5 -0.7 0.5
Bipolar Disorder or Schizophrenia 0.3 0.7 1.4 0.1 1.2
Depressed Affect (Nagel 2018) 1.6 3.4 4.2 -2.1 1.6
Depression (Nagel 2018) 0.8 1.2 1.7 -0.8 1.3
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.1 0.4 -0.4
Neuroticism (Nagel 2018) 1.1 2.6 3.0 -1.7 1.5
Schizophrenia (2018) 0.4 0.8 1.3 0.6 1.1
Schizophrenia vs Biploar Disorder 0.4 0.5 0.6 -0.8 0.6
Worry (Nagel 2018) 0.5 1.1 1.3 -1.0 1.1
Alzheimer’s Disease (in mother) 0.3 0.4 0.7 0.4 -0.8
Alzheimer’s Disease (in father) 3.6 3.9 7.6 -2.8 -0.4
Alzheimer’s Disease (including proxy) 1.5 2.1 3.1 -1.8 -1.1
Crohns Disease (2017) 0.1 0.2 0.2 -0.3 -0.4
Irritable Bowel Disease (IBD) 0.0 0.1 0.2 0.1 0.4
Ulcerative Colitis (UC) 0.7 1.3 1.6 1.0 1.2
Major Depression (MDD) 0.6 0.7 1.4 -1.2 -0.4
Reaction Time 1.0 1.8 3.0 -0.8 -1.7
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.2 0.5 -0.1
Breast Cancer 0.5 1.3 2.4 1.5 -0.5
Ovarian Cancer 1.6 2.1 3.9 0.6 2.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.1 1.6 3.2 -1.8 -0.0
Bipolar Disorder (2011) 0.4 0.4 0.9 0.0 0.9
Body Mass Index (BMI) (2010) 0.2 0.3 0.5 0.7 0.4
Coronary Artery Disease (CAD) 0.3 0.3 0.6 -0.7 0.3
Crohns Disease (2012) 0.3 0.4 0.6 -0.6 -0.7
Mean Putamen Volume 0.4 0.5 0.8 -0.4 -0.9
Fasting Glucose 1.2 1.4 2.6 0.6 1.6
HbA1C 0.4 0.4 0.5 0.5 0.7
HDL Cholesterol 4.6 7.7 14.4 -3.8 1.0
LDL Cholesterol 0.8 1.3 1.6 -1.2 1.0
Lupus 0.6 0.9 1.0 0.9 1.0
Neuroticism (2016) 0.3 0.5 0.9 -0.0 1.0
Primary Biliary Cirrhosis 0.6 0.8 1.7 -1.3 0.1
Rheumatoid Arthritis 0.8 1.1 2.1 0.1 -1.5
Schizophrenia (2014) 0.5 1.2 2.3 0.2 1.5
Triglycerides 0.4 0.7 1.1 1.0 -0.5
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.1 -1.1 0.7
Ulcerative Colitis 0.2 0.2 0.3 -0.5 0.5
Blood Eosinophil Count 0.0 0.3 0.7 -0.1 -0.8
Blood Platelet Count 0.8 9.0 17.1 -4.1 -1.0
Blood Red Count 0.1 0.8 1.5 -0.4 -1.2
Blood White Count 1.0 7.5 10.9 -3.3 -2.0
Heel T-Score 1.2 9.8 11.1 -2.9 -3.3
BMI 1.0 5.8 11.0 -3.3 0.8
Height 1.6 31.2 56.9 7.5 2.4
Waist Hip Ratio (WHR) 0.1 0.3 0.5 0.7 0.3
Systolic Blood Pressure 0.2 1.2 2.4 -1.6 0.2
Smoking Status 0.7 1.6 2.7 0.8 -1.6
Allergy or Eczema 0.8 2.2 2.9 -1.2 1.7
Cardiovascular Disease 0.3 0.9 1.6 -0.5 1.3
Hypothyroidism (self reported) 0.0 0.0 0.1 -0.2 -0.2
Respiratory disease 1.0 2.2 4.0 -2.0 -0.7
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.6 0.1 0.8
Lung FEV1/FVC ratio 0.3 1.5 3.1 -0.0 1.8
Lung FVC 0.0 0.2 0.2 -0.5 -0.3
Neuroticism 0.5 1.1 1.7 -0.7 1.3
Chronotype (morning person) 1.0 2.2 3.5 -0.9 1.9
Hair Pigment 0.0 0.3 0.4 -0.5 -0.6
Tanning 0.3 3.6 7.2 -0.2 2.7
Hand grip strength (left) 1.3 3.4 4.6 2.1 -1.5
Number of treatments/medications taken 0.1 0.2 0.4 -0.7 0.2
Average weekly spirits intake 0.3 0.3 0.6 0.8 0.1
Sensitivity / hurt feelings 1.3 2.2 4.1 -0.6 2.0
Frequency of depressed mood in last 2 weeks 2.8 3.9 5.2 -1.6 2.3
Hearing difficulty/problems: Yes 0.3 0.5 0.6 0.7 0.8
Relative age of first facial hair 0.2 0.4 0.7 0.8 -0.4
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.6 -0.8 0.5
Ever used hormone-replacement therapy (HRT) 0.0 0.1 0.1 -0.0 0.3
Ever had hysterectomy (womb removed) 0.6 0.6 1.2 -0.2 -1.1
Systolic blood pressure, automated reading 0.5 1.5 2.7 -1.6 0.6
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 0.8 -0.6 0.9
Angina 0.6 0.8 1.0 -0.8 1.0
Medication for hormone replacement therapy 0.1 0.1 0.2 -0.1 0.5
Vitamin and mineral supplements 1.0 1.3 2.6 1.6 -0.3
Supplements: Zinc 0.8 0.9 1.2 -1.1 -0.8
Medication: Co-codamol 1.1 1.3 2.6 -1.6 0.2
Medication: Metformin 0.4 0.5 0.9 -0.9 -0.5
Diabetes (father) 0.2 0.2 0.3 0.5 -0.5
Diabetes (mother) 0.5 0.6 1.1 -0.2 -1.1
Severe depression (siblings) 0.3 0.3 0.3 -0.6 0.6
Pack years adult smoking proportion 1.1 1.7 3.2 -1.8 -0.5
Impedance of leg (right) 0.7 3.3 4.7 1.4 -2.2
Leg fat-free mass (left) 0.5 2.8 2.8 1.7 1.7
Trunk fat percentage 0.2 0.6 1.3 -1.1 -0.1
Hand grip strength (right) 2.1 5.7 6.6 2.6 -2.2
Townsend deprivation index at recruitment 0.3 0.4 0.5 0.5 0.7
Current tobacco smoking 0.3 0.5 1.0 0.2 -1.0
Average weekly fortified wine intake 0.3 0.3 0.4 0.6 0.5
Maternal smoking around birth 0.0 0.0 0.0 0.1 -0.0
Fed-up feelings 2.9 5.4 10.0 -0.8 3.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 3.3 -0.4 1.8
Relative age voice broke 0.3 0.5 0.9 0.1 -1.0
Taking other prescription medications 3.8 5.9 7.8 -2.0 2.8
Age when periods started (menarche) 0.3 0.8 1.2 -0.6 -1.1
Bilateral oophorectomy (both ovaries removed) 1.4 1.7 2.9 -1.7 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.4 3.8 -1.7 -1.9
Tinnitus: Yes, but not now, but have in the past 2.0 2.2 3.1 -1.1 1.8
Qualifications: CSEs or equivalent 1.1 1.5 1.8 -1.1 -1.4
Serious illness, injury or assault to yourself 3.2 3.8 4.1 -2.0 1.9
High blood pressure 0.6 1.6 3.1 -0.1 1.8
Hayfever, allergic rhinitis or eczema 1.7 3.8 4.6 -2.1 1.7
Multivitamins +/- minerals 0.9 1.1 2.3 -1.5 -0.0
Stomach or abdominal pain in last month 1.0 1.2 2.3 0.2 1.5
Supplements: Glucosamine 2.2 2.9 5.8 2.4 -0.1
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 1.4 -1.2 -0.8
Medication: Atenolol 0.8 1.0 1.5 1.2 0.7
Medication: Levothyroxine sodium 0.8 1.3 2.5 -1.6 -0.3
Sitting height 1.6 11.1 21.4 4.6 0.8
Chronic bronchitis/emphysema (father) 0.3 0.4 0.7 0.3 0.8
High blood pressure (mother) 0.2 0.3 0.5 -0.1 0.7
Body mass index (BMI) 0.5 2.2 3.3 -1.8 1.1
Impedance of leg (left) 0.7 3.3 6.1 0.7 -2.5
Leg predicted mass (left) 0.6 3.0 3.2 1.8 1.7
Trunk fat mass 0.0 0.1 0.2 -0.1 0.4
Waist circumference 0.3 1.2 2.1 -0.5 1.4
Number of incorrect matches in round 0.3 0.5 0.9 -0.3 1.0
Past tobacco smoking 1.2 2.2 2.6 -1.6 1.4
Alcohol usually taken with meals 0.1 0.2 0.4 0.6 0.0
Nervous feelings 0.4 0.7 1.3 -0.3 1.1
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 2.5 -1.6 1.6
Hearing difficulty/problems with background noise 0.9 1.5 2.9 0.0 1.7
Hair/balding pattern: Pattern 2 1.9 2.4 4.9 0.1 -2.2
Had menopause 0.6 0.7 0.9 1.0 -0.7
Had other major operations 0.2 0.3 0.5 0.0 -0.7
Forced vital capacity (FVC) 0.1 0.3 0.5 0.7 -0.0
Heel bone mineral density (BMD) T-score, automated (right) 3.0 7.0 7.5 -2.5 -2.7
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.8 0.2 0.9
Qualifications: None of the above 0.1 0.3 0.5 -0.0 -0.7
Financial difficulties in last 2 years 1.9 2.5 4.8 -2.2 0.4
Mouth/teeth dental problems 0.6 0.9 1.6 1.3 0.4
Heart attack 0.4 0.5 0.9 -1.0 -0.2
Allergy 1.5 3.5 6.0 2.5 -0.9
Pain all over the body in last month 0.4 0.5 0.8 -0.9 0.3
Diabetes (self-reported) 0.1 0.1 0.2 -0.1 -0.4
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 3.5 -1.9 0.8
Medication: Ramipril 0.5 0.7 1.1 -0.6 1.0
Medication: Simvastatin 1.1 1.6 3.1 0.2 1.8
Fluid intelligence score 0.1 0.1 0.2 0.0 0.5
Illnesses of siblings 0.7 1.0 1.4 1.2 -0.7
Neuroticism score 2.1 4.3 6.7 -1.4 2.6
Weight 0.3 1.3 1.7 0.9 1.3
Impedance of arm (right) 0.1 0.5 1.0 0.2 -1.0
Arm fat percentage (right) 0.7 2.6 4.9 -2.2 0.6
Trunk fat-free mass 1.1 6.4 10.4 3.2 1.6
Hip circumference 0.3 1.3 1.9 -0.8 1.4
Time employed in main current job 2.3 2.6 4.7 0.8 -2.2
Alcohol intake versus 10 years previously 0.2 0.3 0.6 0.8 0.0
Father’s age at death 0.6 0.8 1.6 0.2 -1.3
Worrier / anxious feelings 1.8 3.4 6.8 0.2 2.6
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.5 3.3 -1.8 1.3
Falls in the last year 2.1 2.8 5.5 -2.3 -0.3
Hair/balding pattern: Pattern 3 1.0 1.5 2.3 -0.9 -1.5
Number of live births 0.6 0.8 1.3 -0.5 -1.1
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.2 0.5 -0.0
Pulse rate 0.2 0.4 0.7 -0.1 -0.9
Happiness 1.8 2.2 3.4 1.1 1.8
Noisy workplace 0.7 0.8 1.4 -0.5 1.2
Qualifications: A levels/AS levels or equivalent 0.8 1.8 1.9 1.4 1.3
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 1.4 1.2 -0.8
Mouth/teeth dental problems: Dentures 1.5 2.5 4.7 -2.2 -0.4
Asthma 2.2 4.4 8.8 -3.0 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.4 -0.1 -0.6
Medication: Cholesterol lowering 0.6 0.9 1.8 -0.2 1.4
Depression (self-reported) 2.9 3.5 5.3 -1.3 2.3
Medication: Lansoprazole 0.8 0.9 1.0 -1.0 -1.0
Prospective memory result 0.1 0.1 0.1 -0.3 -0.3
Lung cancer (father) 1.0 1.1 2.3 -1.5 -0.0
Illnesses of mother 0.3 0.3 0.6 0.8 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.4 1.2 -0.1
Pulse wave Arterial Stiffness index 0.2 0.2 0.2 0.5 -0.4
Impedance of arm (left) 0.2 0.9 1.7 0.2 -1.3
Arm fat mass (right) 0.2 0.8 0.8 -0.9 0.9
Trunk predicted mass 1.1 6.4 10.0 3.2 1.6
Standing height 1.8 18.3 36.2 6.0 0.6
Length of working week for main job 0.1 0.1 0.1 -0.3 0.2
Exposure to tobacco smoke at home 1.1 1.2 1.3 -1.1 1.1
Breastfed as a baby 0.5 0.7 1.3 0.0 -1.1
Tense / ‘highly strung’ 0.2 0.4 0.5 -0.6 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.4 2.5 -1.5 1.6
Hair/balding pattern: Pattern 4 0.2 0.6 1.0 0.4 1.0
Birth weight of first child 0.9 1.7 3.3 -1.8 0.3
Peak expiratory flow (PEF) 0.1 0.2 0.4 0.0 -0.6
Pulse wave reflection index 0.0 0.0 0.1 0.2 -0.1
Ever highly irritable/argumentative for 2 days 2.4 2.9 4.3 -2.1 1.2
Loud music exposure frequency 0.1 0.1 0.2 0.1 -0.4
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.6 0.6 0.7
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.4 -0.6 0.4
Blood clot in the leg (DVT) 0.7 0.9 1.5 1.2 0.6
Medication: Paracetamol 0.7 1.2 2.4 -0.2 -1.6
Headache pain in last month 0.5 0.8 1.6 0.2 1.3
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 0.8 -0.9 -0.5
Glaucoma (self-reported) 0.7 0.9 1.7 1.3 -0.3
Gout (self-reported) 1.6 2.1 4.0 2.0 -0.5
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.1 -1.1 0.5
Medication: Amlodipine 0.0 0.1 0.1 -0.1 0.3
Medication: Ventolin 100micrograms inhaler 1.2 1.6 2.3 -0.9 1.5
Birth weight 0.2 0.4 0.8 0.3 0.9
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.3 -0.4 -0.6
High blood pressure (siblings) 0.2 0.2 0.4 -0.6 0.3
Forced vital capacity (FVC), Best measure 0.3 1.0 1.8 1.3 -0.3
Body fat percentage 0.2 0.7 1.3 -1.1 0.2
Leg fat percentage (right) 0.2 0.7 1.1 -1.0 0.5
Arm fat-free mass (right) 0.7 3.4 5.6 2.4 1.1
Exposure to tobacco smoke outside home 0.3 0.4 0.5 -0.7 -0.6
Comparative body size at age 10 0.9 2.5 4.1 -2.0 1.0
Number of full brothers 0.7 0.8 1.5 0.4 1.2
Worry too long after embarrassment 0.3 0.6 0.6 -0.8 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 4.2 5.5 5.7 -2.4 2.3
Wheeze or whistling in the chest in last year 1.1 1.9 3.7 -1.9 0.3
Number of children fathered 0.4 0.5 0.7 0.8 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.6 0.8 -0.0
Age at first live birth 0.0 0.1 0.2 -0.4 -0.1
Pulse wave peak to peak time 0.1 0.1 0.3 0.0 0.5
Health satisfaction 1.3 1.7 2.3 -1.0 1.5
Shortness of breath walking on level ground 1.6 2.0 3.2 -0.8 -1.8
Qualifications: College or University degree 0.1 0.3 0.6 0.8 -0.0
Eye problems/disorders: None of the above 0.1 0.1 0.1 0.3 -0.3
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.0 0.1 0.0
Emphysema/chronic bronchitis 0.2 0.3 0.4 -0.6 0.4
Medication for pain relief, constipation, heartburn 0.6 1.1 1.6 1.3 -0.7
Neck or shoulder pain in last month 1.6 2.3 3.4 -1.9 1.1
Medication: Blood pressure 0.2 0.3 0.6 0.8 -0.2
Angina (self-reported) 0.6 0.8 1.1 -0.7 1.1
Migraine (self-reported) 0.5 0.6 0.6 0.7 0.8
Medication: Ibuprofen 0.6 0.7 1.4 -0.3 -1.2
Medication: Allopurinol 1.9 2.5 4.9 2.2 -0.0
Medication: Omeprazole 0.4 0.5 0.6 -0.7 0.8
Medication: Seretide 50 evohaler 0.8 0.9 1.8 0.2 1.3
Mean time to correctly identify matches 0.5 0.9 1.8 -0.2 -1.4
Heart disease (mother) 0.8 1.0 1.6 -0.6 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.3 -0.6 -0.3
Whole body fat mass 0.1 0.4 0.8 -0.2 0.9
Leg fat mass (right) 0.1 0.4 0.7 -0.2 0.9
Arm predicted mass (right) 0.7 3.8 6.7 2.6 1.0
Pulse rate, automated reading 0.2 0.7 1.5 -1.2 0.1
Alcohol intake frequency. 0.1 0.2 0.3 -0.6 0.1
Comparative height size at age 10 2.1 11.3 19.4 4.4 1.8
Number of full sisters 0.7 0.8 1.4 -0.4 -1.2
Suffer from ‘nerves’ 1.9 3.0 5.5 -0.7 2.3
Overall health rating 0.9 2.0 3.4 -1.8 0.8
Chest pain or discomfort 0.2 0.3 0.5 -0.3 0.7
Had major operations 0.6 0.7 1.3 0.3 1.1
Age at last live birth 1.0 1.4 2.1 -0.8 -1.5
Family relationship satisfaction 0.5 0.7 1.0 -1.0 0.5
Leg pain on walking 0.2 0.3 0.4 -0.3 0.7
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.2 2.3 1.5 -1.4
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.4 -1.2 -0.1
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.3 0.2 1.1
Medication: Aspirin 1.3 1.7 3.1 -0.5 1.8
Supplements: Vitamin C 1.2 1.4 2.6 -0.4 -1.6
Knee pain experienced in last month 0.7 1.1 1.7 -0.6 -1.3
Hypertension (Self-reported) 0.4 1.2 2.4 0.1 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 1.0 -1.0 0.9
Illnesses of father: Heart disease 0.5 0.7 1.4 -1.2 -0.3
Illnesses of siblings: Diabetes 0.4 0.5 0.8 -0.9 -0.3
Smoking status: Previous 1.1 1.7 1.7 1.3 -1.3
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 3.7 1.9 -0.4
Whole body fat-free mass 0.8 4.8 7.0 2.6 1.6
Leg fat-free mass (right) 0.4 2.2 2.2 1.5 1.5
Arm fat percentage (left) 0.5 1.9 3.6 -1.9 0.3
Average weekly red wine intake 0.3 0.5 0.9 0.3 -0.9
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.7 -0.3 0.9
Mood swings 2.5 4.6 4.8 -2.2 2.1
Loneliness, isolation 3.2 4.5 5.2 -2.3 1.9
Long-standing illness, disability or infirmity 1.8 2.8 2.9 -1.7 1.7
Ever had bowel cancer screening 1.3 1.6 2.5 0.8 1.6
Diabetes diagnosed by doctor 0.3 0.4 0.6 -0.7 0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 2.8 -1.7 -0.0
Friendships satisfaction 0.4 0.4 0.9 -0.1 0.9
Qualifications: nursing, teaching 1.2 1.9 3.0 1.7 0.9
Commuting to job workplace: Walk 0.3 0.4 0.7 -0.0 -0.9
Eye problems/disorders: Cataract 0.2 0.2 0.2 0.5 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.6 -1.3 0.2
Medication for cholesterol 0.0 0.0 0.0 -0.1 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 1.5 -1.2 1.1
Back pain experienced in last month 2.8 4.1 5.1 -2.2 1.8
Mineral and other dietary supplements 0.2 0.3 0.6 -0.8 0.1
Breast cancer (self-reported) 1.1 1.4 2.7 -1.6 -0.2
Asthma (self-reported) 2.1 4.1 8.1 -2.9 0.3
Osteoporosis (self-reported) 0.5 0.6 1.0 1.0 0.4
Osteoarthritis (self-reported) 1.6 2.1 2.4 -1.6 1.4
Medication: Aspirin 1.1 1.4 2.3 -0.8 1.5
Medication: Gliclazide 0.0 0.0 0.0 0.0 0.0
Illnesses of father: None of the above (group 1) 2.3 2.8 5.4 -0.5 2.3
Smoking status: Current 0.3 0.5 1.0 0.3 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 3.2 -1.8 -0.5
Whole body water mass 0.7 4.1 6.1 2.5 1.5
Leg predicted mass (right) 0.4 2.2 2.3 1.5 1.4
Arm fat mass (left) 0.2 0.9 0.9 -0.9 1.0
Number of self-reported non-cancer illnesses 4.7 8.2 8.4 -2.8 2.9
Average weekly champagne plus white wine intake 0.5 0.7 0.9 0.7 -0.9
Miserableness 1.7 3.0 5.0 -1.0 2.2
Guilty feelings 0.8 1.1 1.6 -0.8 1.3
Wears glasses or contact lenses 1.2 1.4 2.0 -0.9 -1.4
Ever taken oral contraceptive pill 0.7 0.8 0.9 0.9 0.8
Hearing aid user 0.0 0.0 0.1 -0.1 -0.3
Mother’s age at death 0.9 1.1 1.8 1.3 0.6
Financial situation satisfaction 2.2 2.8 5.2 -0.6 2.3
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.6 -0.6 0.8
Commuting to job workplace: Public transport 0.6 0.7 1.2 -0.5 1.1
Eye problems/disorders: Glaucoma 3.0 3.5 6.7 2.6 -0.5
Medication: Blood pressure 0.3 0.5 1.0 -0.3 1.0
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.8 -1.3 -0.2
Supplements: Fish oil (including cod liver oil) 0.0 0.1 0.1 0.2 0.3
High cholesterol (Self-reported) 0.2 0.4 0.8 0.2 0.9
Medication: Bendroflumethiazide 0.5 0.8 1.0 -1.0 0.8
Medication: Paracetamol 1.1 1.6 3.2 -0.3 -1.8
Medication: Lisinopril 0.2 0.3 0.6 -0.8 -0.1
Medication: Atorvastatin 0.1 0.1 0.2 -0.2 -0.4
Illnesses of father: High blood pressure 1.4 1.8 2.9 1.7 -0.9
Alcohol drinker status: Never 0.4 0.5 0.5 0.7 0.6
Ever smoked 1.2 2.2 2.4 1.6 -1.4
Basal metabolic rate 0.6 3.6 4.7 2.2 1.6
Leg fat percentage (left) 0.3 1.3 2.2 -1.5 0.5
Arm fat-free mass (left) 0.7 3.5 4.4 2.1 1.6
Number of operations (self-reported) 0.6 0.9 1.8 -1.3 0.3
Average weekly beer plus cider intake 1.1 1.6 3.2 -0.1 1.8
Irritability 1.6 2.8 5.5 -0.3 2.3
Risk taking 1.0 1.4 2.4 -0.6 1.6
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.4 -0.6 1.2
Fractured/broken bones in last 5 years 1.5 1.9 3.7 -1.9 -0.3
Age started oral contraceptive pill 0.7 0.9 1.0 -1.0 0.9
Diastolic blood pressure, automated reading 0.8 2.4 4.2 -2.0 0.9
Ever depressed for a whole week 0.1 0.1 0.2 0.5 0.2
Unable to work because of sickness or disability 2.4 3.2 6.2 -2.5 -0.3
Commuting to job workplace: Cycle 0.2 0.2 0.5 0.7 0.2
Myopia 1.0 1.4 2.3 0.7 -1.5
Vascular/heart problems diagnosed by doctor 0.9 2.5 4.8 0.4 -2.2
Cholesterol lowering medication 0.3 0.5 0.7 -0.5 0.8
Medication: Omeprazole (e.g. Zanprol) 1.7 2.0 4.0 -2.0 0.1
Pain experienced in last month 1.6 2.6 3.2 1.8 -1.4
Supplements: Calcium 0.5 0.5 0.7 0.6 0.8
Basal cell carcinoma (self-reported) 1.6 1.9 3.3 -1.8 -0.7
Heart attack/myocardial infarction (self-reported) 0.4 0.6 1.1 -1.1 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.2 1.1 0.6
Heart disease (siblings) 0.8 0.9 1.8 0.3 1.3
Alcohol drinker status: Previous 2.8 3.2 3.8 -1.9 -1.6
Pack years of smoking 1.0 1.5 2.9 -1.7 0.0
Impedance of whole body 0.3 1.6 2.9 0.4 -1.7
Leg fat mass (left) 0.1 0.4 0.8 -0.3 0.9
Arm predicted mass (left) 0.6 2.9 3.9 2.0 1.3