Hub : Genes

GGTA1P

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.150	0.0550	1.1e-04	0.103	NA	0.125	NA	0.120	2.7e-06	NA	2.3e-07	NA	3.8e-07
2	GTEx	Esophagus Mucosa	0.110	0.0370	7.0e-06	0.113	NA	0.113	NA	0.117	6.0e-08	NA	5.5e-08	NA	3.4e-08
3	GTEx	Heart Atrial Appendage	0.309	0.0580	9.3e-15	0.397	NA	0.431	NA	0.430	4.7e-19	NA	4.3e-21	NA	5.4e-21
4	GTEx	Heart Left Ventricle	0.298	0.0518	0.0e+00	0.427	NA	0.421	NA	0.438	1.4e-24	NA	3.5e-24	NA	2.1e-25
5	GTEx	Muscle Skeletal	0.134	0.0348	8.1e-11	0.164	NA	0.155	NA	0.161	7.3e-16	NA	4.6e-15	NA	1.3e-15
6	GTEx	Whole Blood	0.139	0.0350	3.0e-09	0.140	NA	0.115	NA	0.126	6.8e-13	NA	1.0e-10	NA	1.1e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.4	0.6	0.8	-0.8	0.7	-0.6	-0.8	-0.8	0.9
Bipolar Disorder or Schizophrenia	0.8	1.8	2.2	-1.3	1.4	-1.2	-1.3	-1.3	1.5
Depressed Affect (Nagel 2018)	0.6	1.2	1.6	1.2	-1.1	1.3	1.2	0.9	-1.0
Depression (Nagel 2018)	0.3	0.5	0.7	0.8	-0.5	0.8	0.8	0.6	-0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	-0.4	0.2	-0.6	-0.5	-0.3	0.3
Neuroticism (Nagel 2018)	0.1	0.2	0.4	0.5	-0.4	0.6	0.6	0.3	-0.4
Schizophrenia (2018)	0.6	1.3	1.5	-1.1	1.2	-1.1	-1.1	-1.1	1.2
Schizophrenia vs Biploar Disorder	0.5	0.6	0.8	0.8	-0.6	0.9	0.9	0.8	-0.8
Worry (Nagel 2018)	0.0	0.1	0.2	0.2	-0.1	0.3	0.4	0.2	-0.3
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	-0.2	0.1	-0.3	-0.2	-0.1	0.1
Alzheimer’s Disease (in father)	2.0	2.1	2.7	1.4	-1.6	1.4	1.4	1.5	-1.5
Alzheimer’s Disease (including proxy)	1.2	1.8	2.2	1.2	-1.5	1.1	1.2	1.4	-1.4
Crohns Disease (2017)	1.6	3.6	4.2	-2.0	1.6	-1.9	-2.0	-1.8	1.9
Irritable Bowel Disease (IBD)	2.1	5.0	5.6	-2.3	2.0	-2.2	-2.4	-2.2	2.3
Ulcerative Colitis (UC)	1.7	3.1	3.4	-1.8	1.8	-1.7	-1.8	-1.8	1.8
Major Depression (MDD)	1.4	1.7	1.9	1.3	-1.1	1.4	1.4	1.2	-1.3
Reaction Time	2.9	5.5	6.3	2.3	-2.3	2.1	2.3	2.5	-2.5
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.0	-0.1	-0.0	-0.1	-0.1	-0.1	0.1
Breast Cancer	2.4	5.7	6.0	-2.4	2.2	-2.4	-2.5	-2.4	2.3
Ovarian Cancer	1.4	1.9	2.3	-1.4	1.3	-1.2	-1.3	-1.5	1.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	4.3	6.3	7.5	2.6	-2.4	2.7	2.6	2.3	-2.4
Bipolar Disorder (2011)	1.5	1.5	1.8	-1.2	1.2	-1.1	-1.2	-1.2	1.4
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	0.2	0.1	0.3	0.2	0.1	0.1
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.4	-0.3	0.3	0.3	0.4	-0.4
Crohns Disease (2012)	0.3	0.4	0.5	-0.7	0.4	-0.6	-0.7	-0.7	0.7
Mean Putamen Volume	0.0	0.0	0.1	-0.0	-0.2	-0.1	-0.0	-0.1	-0.1
Fasting Glucose	0.4	0.5	1.0	-0.7	1.0	-0.5	-0.3	-0.8	0.6
HbA1C	0.1	0.1	0.2	-0.1	0.4	-0.0	0.1	-0.4	0.0
HDL Cholesterol	0.1	0.2	0.3	0.4	-0.5	0.3	0.4	0.4	-0.5
LDL Cholesterol	3.2	5.1	5.9	-2.3	2.2	-2.4	-2.3	-2.1	2.2
Lupus	0.4	0.5	0.8	-0.7	0.8	-0.5	-0.6	-0.9	0.8
Neuroticism (2016)	0.0	0.0	0.1	0.3	0.0	0.3	0.2	-0.0	-0.2
Primary Biliary Cirrhosis	1.2	1.6	1.9	1.3	-1.2	1.4	1.3	1.3	-1.3
Rheumatoid Arthritis	1.5	2.0	2.4	1.4	-1.5	1.5	1.4	1.4	-1.3
Schizophrenia (2014)	0.4	0.9	1.1	-0.9	1.1	-0.8	-0.9	-1.0	1.1
Triglycerides	0.1	0.1	0.2	-0.2	0.0	-0.3	-0.3	-0.4	0.3
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.1	0.8	-1.0	0.9	0.9	0.9	-0.6
Ulcerative Colitis	1.1	1.6	1.7	-1.3	1.2	-1.2	-1.3	-1.3	1.3
Blood Eosinophil Count	0.6	4.9	5.9	2.1	-2.4	1.9	2.2	2.1	-2.4
Blood Platelet Count	0.0	0.0	0.1	0.0	0.1	-0.3	-0.1	0.0	-0.3
Blood Red Count	1.0	9.8	11.1	3.1	-3.0	3.1	3.1	3.3	-3.1
Blood White Count	0.8	5.6	6.3	2.3	-2.3	2.3	2.3	2.5	-2.5
Heel T-Score	0.5	4.0	5.7	1.8	-2.2	1.7	1.7	2.4	-2.1
BMI	1.5	8.7	10.2	3.0	-2.6	3.2	3.1	2.9	-2.9
Height	2.9	56.4	60.5	-7.5	7.3	-7.4	-7.5	-7.6	7.8
Waist Hip Ratio (WHR)	1.5	6.6	7.5	-2.6	2.7	-2.6	-2.6	-2.3	2.5
Systolic Blood Pressure	0.7	3.4	4.2	1.8	-1.8	2.1	1.9	1.8	-1.7
Smoking Status	0.9	2.1	2.3	-1.5	1.4	-1.5	-1.5	-1.5	1.3
Allergy or Eczema	0.9	2.4	2.8	1.6	-1.4	1.6	1.7	1.4	-1.6
Cardiovascular Disease	0.0	0.1	0.1	-0.2	0.3	0.0	-0.0	-0.4	0.3
Hypothyroidism (self reported)	1.7	3.9	4.5	2.0	-2.1	1.9	2.0	1.9	-2.0
Respiratory disease	4.6	10.2	11.5	3.3	-3.0	3.0	3.2	3.4	-3.4
Type 2 Diabetes (T2D) (2018)	1.9	3.6	4.2	-1.9	1.9	-1.6	-1.9	-1.9	2.1
Lung FEV1/FVC ratio	0.2	0.8	1.1	-0.8	1.1	-0.7	-0.8	-1.0	0.9
Lung FVC	0.0	0.2	0.3	0.4	-0.6	0.5	0.3	0.5	-0.4
Neuroticism	0.2	0.5	0.9	0.7	-0.4	0.9	0.9	0.5	-0.7
Chronotype (morning person)	0.5	1.2	1.6	1.1	-1.1	1.3	1.1	1.0	-0.9
Hair Pigment	0.2	5.6	6.0	2.3	-2.3	2.3	2.4	2.4	-2.5
Tanning	0.0	0.4	0.7	0.7	-0.6	0.8	0.8	0.3	-0.5
Hand grip strength (left)	0.3	0.7	0.9	-0.9	0.5	-0.8	-0.9	-0.8	0.9
Number of treatments/medications taken	0.1	0.1	0.2	-0.3	0.5	-0.2	-0.3	-0.4	0.4
Average weekly spirits intake	0.2	0.2	0.3	-0.4	0.4	-0.6	-0.5	-0.4	0.4
Sensitivity / hurt feelings	0.0	0.0	0.1	-0.1	0.2	-0.1	-0.1	-0.4	0.3
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.1	1.3	-1.0	1.5	1.4	1.1	-1.1
Hearing difficulty/problems: Yes	0.3	0.4	0.6	-0.6	0.7	-0.5	-0.6	-0.7	0.8
Relative age of first facial hair	0.2	0.5	0.8	-0.7	0.5	-0.9	-0.7	-0.8	0.6
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.0	0.9	-0.9	0.9	1.0	1.0	-0.9
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.2	0.5	-0.3	0.4	0.5	0.3	-0.4
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	0.1	-0.3	-0.0	0.0	0.2	-0.2
Systolic blood pressure, automated reading	0.7	2.0	2.5	1.4	-1.3	1.6	1.4	1.5	-1.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.3	-0.2	0.4	0.4	0.3	-0.2
Angina	2.4	3.2	4.5	1.8	-1.5	2.1	1.9	1.6	-1.6
Medication for hormone replacement therapy	1.6	1.7	2.0	-1.4	1.2	-1.4	-1.3	-1.3	1.3
Vitamin and mineral supplements	0.3	0.5	0.6	-0.6	0.8	-0.6	-0.6	-0.8	0.7
Supplements: Zinc	0.2	0.3	0.5	0.5	-0.7	0.5	0.4	0.5	-0.5
Medication: Co-codamol	1.5	1.8	2.0	1.4	-1.3	1.4	1.4	1.2	-1.3
Medication: Metformin	0.3	0.4	0.6	-0.7	0.8	-0.5	-0.6	-0.7	0.7
Diabetes (father)	0.8	0.9	1.0	1.0	-0.9	1.0	1.0	1.0	-1.0
Diabetes (mother)	0.0	0.1	0.1	-0.2	0.0	-0.2	-0.3	-0.1	0.3
Severe depression (siblings)	0.3	0.4	0.4	-0.6	0.7	-0.5	-0.6	-0.6	0.6
Pack years adult smoking proportion	1.4	2.2	2.8	1.5	-1.4	1.3	1.4	1.7	-1.6
Impedance of leg (right)	0.1	0.6	1.0	0.8	-0.8	0.6	0.7	1.0	-0.9
Leg fat-free mass (left)	0.9	4.7	5.2	-2.1	2.2	-2.0	-2.1	-2.3	2.3
Trunk fat percentage	1.3	5.0	5.4	2.3	-1.9	2.3	2.3	2.3	-2.3
Hand grip strength (right)	1.1	2.9	3.5	-1.8	1.3	-1.8	-1.9	-1.6	1.8
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.5	-0.3	0.3	0.5	0.5	-0.5
Current tobacco smoking	0.3	0.5	0.8	-0.7	0.7	-0.9	-0.7	-0.7	0.5
Average weekly fortified wine intake	0.0	0.1	0.1	-0.3	0.2	-0.3	-0.2	-0.0	0.2
Maternal smoking around birth	1.9	2.8	3.1	-1.8	1.7	-1.7	-1.7	-1.6	1.6
Fed-up feelings	0.3	0.6	1.0	0.8	-0.5	1.0	1.0	0.5	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.2	0.4	-0.1	-0.1	-0.4	0.3
Relative age voice broke	0.9	1.4	1.7	-1.2	1.1	-1.3	-1.3	-1.2	1.1
Taking other prescription medications	0.9	1.4	2.1	1.3	-1.1	1.4	1.3	1.0	-1.0
Age when periods started (menarche)	0.0	0.0	0.1	-0.1	-0.1	-0.3	-0.1	-0.2	0.0
Bilateral oophorectomy (both ovaries removed)	2.6	3.0	3.3	1.7	-1.8	1.7	1.7	1.8	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.7	0.9	-1.2	0.9	0.9	1.3	-1.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.2	-0.9	0.9	-0.7	-0.9	-1.0	1.1
Qualifications: CSEs or equivalent	5.5	7.2	7.8	2.7	-2.8	2.6	2.7	2.6	-2.8
Serious illness, injury or assault to yourself	4.7	5.7	6.6	2.4	-2.1	2.5	2.6	2.3	-2.4
High blood pressure	0.6	1.8	2.3	-1.3	1.5	-1.2	-1.2	-1.4	1.4
Hayfever, allergic rhinitis or eczema	3.0	6.6	7.3	2.6	-2.4	2.6	2.7	2.5	-2.6
Multivitamins +/- minerals	0.4	0.4	0.8	0.6	-0.9	0.6	0.6	0.7	-0.6
Stomach or abdominal pain in last month	0.0	0.0	0.1	0.2	0.0	0.2	0.2	-0.1	0.0
Supplements: Glucosamine	3.4	4.5	5.2	-2.1	2.1	-1.9	-2.0	-2.3	2.2
Diverticular disease/diverticulitis (self-reported)	2.0	2.3	2.7	1.5	-1.6	1.5	1.4	1.6	-1.4
Medication: Atenolol	1.0	1.2	1.6	-1.1	1.0	-1.0	-1.0	-1.3	1.2
Medication: Levothyroxine sodium	2.3	3.9	4.5	2.0	-2.1	1.9	1.9	1.9	-2.0
Sitting height	3.8	26.9	27.5	-5.2	5.1	-5.2	-5.2	-5.2	5.2
Chronic bronchitis/emphysema (father)	1.2	1.4	1.9	-1.2	1.0	-1.0	-1.2	-1.2	1.4
High blood pressure (mother)	1.0	1.4	1.6	1.2	-1.2	1.2	1.3	1.1	-1.2
Body mass index (BMI)	1.4	6.2	7.1	2.5	-2.2	2.7	2.6	2.4	-2.4
Impedance of leg (left)	0.4	2.1	2.8	1.4	-1.5	1.2	1.3	1.7	-1.6
Leg predicted mass (left)	0.9	4.6	5.1	-2.1	2.2	-2.0	-2.1	-2.3	2.2
Trunk fat mass	0.3	1.3	1.5	1.2	-0.8	1.2	1.2	1.2	-1.1
Waist circumference	0.1	0.3	0.5	0.6	-0.3	0.7	0.7	0.6	-0.6
Number of incorrect matches in round	0.9	1.5	1.6	1.2	-1.2	1.2	1.3	1.2	-1.2
Past tobacco smoking	0.6	1.1	1.3	1.1	-1.0	1.1	1.0	1.1	-0.9
Alcohol usually taken with meals	0.1	0.1	0.1	-0.3	-0.1	-0.3	-0.3	-0.4	0.3
Nervous feelings	0.1	0.1	0.2	0.3	-0.1	0.5	0.4	0.3	-0.2
Frequency of tenseness / restlessness in last 2 weeks	2.7	4.1	4.9	2.1	-1.8	2.2	2.2	1.9	-2.0
Hearing difficulty/problems with background noise	0.2	0.3	0.6	-0.5	0.6	-0.3	-0.5	-0.8	0.7
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.3	-0.4	0.1	0.2	0.4	-0.4
Had menopause	0.2	0.3	0.5	-0.5	0.4	-0.7	-0.6	-0.4	0.4
Had other major operations	1.1	1.3	1.5	1.2	-1.2	1.0	1.1	1.2	-1.2
Forced vital capacity (FVC)	0.2	0.7	0.8	-0.8	0.8	-0.8	-0.9	-0.8	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	2.3	1.0	-1.4	0.9	1.0	1.5	-1.4
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	-0.3	0.3
Qualifications: None of the above	0.0	0.1	0.2	0.3	-0.3	0.2	0.3	0.5	-0.3
Financial difficulties in last 2 years	2.3	3.2	3.5	1.8	-1.6	1.8	1.8	1.9	-1.8
Mouth/teeth dental problems	0.5	0.7	0.9	-0.9	0.7	-0.7	-0.9	-0.8	1.0
Heart attack	0.2	0.2	0.3	0.4	-0.3	0.5	0.5	0.6	-0.5
Allergy	3.9	8.9	9.7	-3.0	2.8	-2.9	-3.1	-3.0	3.1
Pain all over the body in last month	6.5	7.0	7.7	2.7	-2.5	2.7	2.8	2.6	-2.7
Diabetes (self-reported)	1.9	3.0	3.4	-1.8	1.8	-1.6	-1.8	-1.6	1.8
Hayfever/allergic rhinitis (self-reported)	4.0	5.4	6.0	2.4	-2.1	2.4	2.4	2.2	-2.4
Medication: Ramipril	0.4	0.5	0.7	-0.8	0.8	-0.5	-0.7	-0.7	0.9
Medication: Simvastatin	0.3	0.4	0.7	-0.6	0.6	-0.3	-0.6	-0.8	0.8
Fluid intelligence score	0.8	1.6	1.7	-1.3	1.1	-1.3	-1.3	-1.2	1.3
Illnesses of siblings	1.4	2.0	2.2	-1.4	1.4	-1.4	-1.5	-1.4	1.4
Neuroticism score	0.5	1.0	1.6	1.1	-0.7	1.2	1.2	0.7	-0.9
Weight	0.0	0.1	0.2	-0.2	0.5	-0.1	-0.2	-0.3	0.4
Impedance of arm (right)	0.0	0.1	0.3	0.3	-0.2	0.1	0.2	0.5	-0.5
Arm fat percentage (right)	2.1	8.4	9.1	2.9	-2.5	3.0	3.0	3.0	-2.9
Trunk fat-free mass	2.1	11.8	13.1	-3.4	3.4	-3.3	-3.4	-3.5	3.6
Hip circumference	0.8	3.6	4.1	2.0	-1.7	2.0	2.0	1.9	-1.8
Time employed in main current job	2.1	2.5	3.0	-1.7	1.3	-1.7	-1.7	-1.4	1.5
Alcohol intake versus 10 years previously	0.8	1.3	1.6	-1.1	1.0	-1.1	-1.1	-1.2	1.2
Father’s age at death	0.1	0.1	0.1	0.3	-0.3	0.3	0.2	0.3	-0.3
Worrier / anxious feelings	0.3	0.5	0.7	-0.7	0.8	-0.6	-0.5	-0.8	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	0.2	-0.2	0.3	0.3	0.2	-0.2
Falls in the last year	0.9	1.2	1.3	1.1	-1.0	1.1	1.0	1.1	-1.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	0.4	-0.4	0.3	0.3	0.6	-0.5
Number of live births	0.4	0.6	0.8	0.8	-0.9	0.7	0.7	0.8	-0.8
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.1	-0.3	0.3	-0.3	-0.3	-0.3	0.3
Pulse rate	1.3	2.1	2.4	-1.4	1.5	-1.5	-1.6	-1.3	1.4
Happiness	0.3	0.4	0.6	-0.6	0.8	-0.5	-0.5	-0.7	0.7
Noisy workplace	1.0	1.2	1.5	1.1	-1.0	1.2	1.1	1.1	-1.0
Qualifications: A levels/AS levels or equivalent	0.6	1.3	1.9	-1.1	1.4	-1.0	-1.0	-1.2	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	1.4	-1.2	1.0	-1.2	-1.2	-0.9	1.1
Mouth/teeth dental problems: Dentures	0.7	1.1	1.8	1.1	-0.8	0.9	1.0	1.3	-1.2
Asthma	6.2	12.2	12.8	3.6	-3.3	3.4	3.5	3.6	-3.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.8	-0.7	0.9	-0.8	-0.7	-0.7	0.5
Medication: Cholesterol lowering	0.6	0.9	1.3	-1.0	1.0	-0.6	-0.9	-1.0	1.1
Depression (self-reported)	0.0	0.0	0.1	0.0	0.3	0.2	0.0	-0.0	0.2
Medication: Lansoprazole	2.5	2.8	3.2	1.7	-1.7	1.7	1.7	1.6	-1.8
Prospective memory result	0.5	0.6	0.7	0.8	-0.9	0.6	0.8	0.8	-0.8
Lung cancer (father)	0.3	0.4	0.6	0.6	-0.5	0.6	0.6	0.8	-0.7
Illnesses of mother	0.7	0.8	0.9	-0.9	1.0	-0.9	-0.9	-0.9	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	0.9	-0.9	0.9	-0.9	-0.9	-0.9	1.0
Pulse wave Arterial Stiffness index	4.8	5.6	6.1	-2.4	2.3	-2.5	-2.5	-2.3	2.3
Impedance of arm (left)	0.0	0.1	0.2	0.2	-0.2	0.0	0.2	0.4	-0.4
Arm fat mass (right)	0.6	2.4	2.8	1.6	-1.2	1.7	1.7	1.6	-1.5
Trunk predicted mass	2.0	11.6	13.0	-3.4	3.4	-3.2	-3.4	-3.5	3.6
Standing height	3.7	36.5	37.7	-6.0	5.8	-6.1	-6.1	-6.0	6.1
Length of working week for main job	2.0	2.2	2.4	1.5	-1.5	1.6	1.4	1.5	-1.3
Exposure to tobacco smoke at home	3.3	3.7	4.2	1.9	-1.7	1.8	2.0	1.9	-2.0
Breastfed as a baby	0.7	0.9	1.7	0.9	-1.3	0.9	0.9	0.8	-0.9
Tense / ‘highly strung’	0.0	0.1	0.2	-0.2	0.4	-0.1	-0.1	-0.4	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.4	1.1	-0.9	1.2	1.2	1.0	-1.0
Hair/balding pattern: Pattern 4	0.1	0.4	0.5	-0.6	0.7	-0.4	-0.5	-0.6	0.7
Birth weight of first child	0.5	0.9	1.1	-1.0	1.1	-1.0	-1.0	-0.8	0.9
Peak expiratory flow (PEF)	0.5	1.1	1.3	1.0	-1.2	1.1	1.0	1.0	-1.0
Pulse wave reflection index	2.3	2.8	3.2	-1.7	1.8	-1.8	-1.7	-1.5	1.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.8	0.7	-0.4	0.8	0.8	0.9	-0.8
Loud music exposure frequency	0.1	0.1	0.2	-0.3	0.5	-0.3	-0.3	-0.2	0.3
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	-0.2	0.3	-0.0	-0.1	-0.3	0.2
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	-0.1	0.3	-0.1	-0.1	-0.3	0.1
Blood clot in the leg (DVT)	0.5	0.7	0.8	-0.9	0.8	-0.8	-0.9	-0.9	0.8
Medication: Paracetamol	0.0	0.1	0.2	-0.3	0.3	-0.4	-0.3	-0.1	0.1
Headache pain in last month	0.1	0.1	0.2	0.5	-0.3	0.3	0.4	0.1	-0.4
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	2.1	1.4	-1.3	1.2	1.3	1.4	-1.4
Glaucoma (self-reported)	0.1	0.1	0.2	-0.3	0.4	-0.4	-0.3	-0.3	0.2
Gout (self-reported)	1.6	2.2	2.3	-1.5	1.5	-1.4	-1.5	-1.5	1.5
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	2.6	1.5	-1.6	1.4	1.5	1.4	-1.5
Medication: Amlodipine	0.6	0.8	0.9	-0.9	0.9	-0.9	-0.9	-0.9	1.0
Medication: Ventolin 100micrograms inhaler	1.1	1.4	1.8	1.2	-0.9	1.3	1.3	1.0	-1.1
Birth weight	0.4	0.8	1.3	-0.9	1.1	-0.8	-0.9	-0.9	0.9
Chronic bronchitis/emphysema (mother)	0.0	0.1	0.1	0.3	-0.2	0.2	0.2	0.2	-0.3
High blood pressure (siblings)	0.3	0.5	0.7	0.6	-0.8	0.7	0.7	0.7	-0.6
Forced vital capacity (FVC), Best measure	0.3	1.1	1.3	-1.1	1.0	-1.0	-1.1	-1.0	1.1
Body fat percentage	1.7	6.8	7.5	2.7	-2.2	2.7	2.7	2.7	-2.6
Leg fat percentage (right)	2.5	9.2	10.0	3.1	-2.6	3.1	3.2	3.1	-3.0
Arm fat-free mass (right)	1.0	4.9	5.8	-2.2	2.1	-2.0	-2.2	-2.3	2.4
Exposure to tobacco smoke outside home	0.7	0.9	1.0	1.0	-0.8	1.0	0.9	1.0	-1.0
Comparative body size at age 10	0.8	2.2	2.4	1.4	-1.6	1.5	1.5	1.4	-1.4
Number of full brothers	0.0	0.0	0.0	0.1	0.0	0.2	0.1	-0.0	0.0
Worry too long after embarrassment	0.1	0.2	0.3	0.4	-0.3	0.4	0.6	0.2	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.3	4.2	1.9	-1.5	2.1	1.9	1.7	-1.7
Wheeze or whistling in the chest in last year	2.1	3.7	4.1	2.0	-1.6	2.0	2.0	2.0	-2.0
Number of children fathered	0.7	0.8	1.1	-0.8	1.1	-0.7	-0.8	-1.1	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	0.3	-0.5	0.4	0.3	0.3	-0.3
Age at first live birth	0.0	0.0	0.0	-0.2	0.1	-0.2	-0.1	-0.0	0.1
Pulse wave peak to peak time	2.5	2.9	3.3	1.7	-1.6	1.8	1.8	1.7	-1.7
Health satisfaction	1.3	1.7	2.2	1.3	-1.0	1.5	1.4	1.3	-1.2
Shortness of breath walking on level ground	1.5	1.7	2.1	1.3	-1.3	1.2	1.3	1.5	-1.4
Qualifications: College or University degree	1.1	3.5	4.1	-1.8	1.8	-1.9	-1.8	-2.0	1.8
Eye problems/disorders: None of the above	0.0	0.0	0.1	0.1	-0.4	0.1	0.0	-0.1	-0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	0.5	-0.4	0.5	0.5	0.4	-0.5
Emphysema/chronic bronchitis	0.8	0.9	1.4	1.0	-0.9	0.9	0.8	1.2	-0.9
Medication for pain relief, constipation, heartburn	0.3	0.5	0.6	0.6	-0.7	0.6	0.6	0.8	-0.7
Neck or shoulder pain in last month	0.4	0.6	0.8	0.7	-0.5	0.7	0.8	0.9	-0.8
Medication: Blood pressure	1.1	1.9	2.1	-1.4	1.4	-1.3	-1.4	-1.5	1.4
Angina (self-reported)	2.1	2.8	4.0	1.7	-1.4	2.0	1.8	1.5	-1.5
Migraine (self-reported)	0.4	0.5	0.9	-0.7	0.5	-0.5	-0.7	-0.9	0.9
Medication: Ibuprofen	0.5	0.6	0.8	-0.8	0.9	-0.9	-0.8	-0.8	0.5
Medication: Allopurinol	0.6	0.7	0.9	-0.8	0.9	-0.8	-0.8	-0.9	0.9
Medication: Omeprazole	0.2	0.2	0.4	0.5	-0.6	0.5	0.5	0.3	-0.4
Medication: Seretide 50 evohaler	1.1	1.3	1.6	1.2	-0.9	1.3	1.2	1.1	-1.0
Mean time to correctly identify matches	1.1	2.2	2.7	1.4	-1.5	1.3	1.4	1.6	-1.6
Heart disease (mother)	0.1	0.1	0.2	-0.3	0.5	-0.1	-0.2	-0.2	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.5	0.6	-0.6	0.6	0.7	0.7	-0.7
Whole body fat mass	0.5	1.9	2.3	1.4	-1.0	1.5	1.5	1.4	-1.4
Leg fat mass (right)	0.7	2.7	3.2	1.7	-1.3	1.8	1.8	1.7	-1.6
Arm predicted mass (right)	1.2	6.2	7.0	-2.5	2.4	-2.3	-2.5	-2.6	2.7
Pulse rate, automated reading	1.7	5.5	6.3	-2.3	2.5	-2.4	-2.4	-2.2	2.2
Alcohol intake frequency.	1.0	2.2	2.5	1.5	-1.6	1.4	1.4	1.5	-1.4
Comparative height size at age 10	3.5	19.5	21.1	-4.4	4.5	-4.3	-4.4	-4.3	4.6
Number of full sisters	1.8	2.1	2.5	1.5	-1.5	1.3	1.5	1.4	-1.6
Suffer from ‘nerves’	0.0	0.1	0.1	0.2	0.3	0.3	0.2	-0.2	0.0
Overall health rating	1.7	3.6	4.1	1.9	-1.7	2.0	1.9	1.9	-1.8
Chest pain or discomfort	0.6	0.8	0.9	0.9	-0.8	1.0	1.0	0.9	-0.8
Had major operations	2.1	2.5	3.3	1.6	-1.5	1.8	1.7	1.3	-1.4
Age at last live birth	0.5	0.7	0.9	0.8	-0.8	0.7	0.8	1.0	-0.9
Family relationship satisfaction	0.0	0.0	0.0	0.0	-0.1	0.2	0.0	0.0	0.0
Leg pain on walking	0.1	0.1	0.2	-0.2	0.4	-0.3	-0.3	-0.4	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.2	0.9	-0.7	0.6	0.8	1.0	-1.1
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.2	0.1	0.3	0.2	0.2	-0.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	1.8	-1.0	1.1	-1.0	-1.1	-1.4	1.2
Medication: Aspirin	0.6	0.8	1.1	-0.9	0.9	-0.6	-0.8	-0.9	1.1
Supplements: Vitamin C	0.5	0.6	0.8	-0.8	0.7	-0.8	-0.9	-0.6	0.7
Knee pain experienced in last month	0.0	0.0	0.1	-0.1	0.4	-0.3	-0.2	0.1	-0.1
Hypertension (Self-reported)	0.7	2.0	2.4	-1.4	1.6	-1.3	-1.3	-1.5	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	-0.4	0.5	-0.5	-0.5	-0.6	0.4
Illnesses of father: Heart disease	2.0	2.8	3.2	1.6	-1.6	1.7	1.8	1.6	-1.8
Illnesses of siblings: Diabetes	0.0	0.0	0.0	0.0	-0.0	-0.1	-0.0	0.1	-0.1
Smoking status: Previous	0.4	0.6	0.8	-0.9	0.7	-0.8	-0.8	-0.8	0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	2.8	-1.4	1.7	-1.4	-1.4	-1.4	1.3
Whole body fat-free mass	1.6	9.0	10.0	-3.0	3.0	-2.8	-2.9	-3.1	3.2
Leg fat-free mass (right)	0.8	4.2	4.7	-2.0	2.1	-1.9	-2.0	-2.2	2.1
Arm fat percentage (left)	2.0	8.0	8.7	2.9	-2.4	2.9	3.0	2.9	-2.9
Average weekly red wine intake	0.2	0.3	0.5	-0.6	0.4	-0.6	-0.6	-0.7	0.5
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.1	0.9	-1.0	1.0	0.9	0.8	-0.7
Mood swings	1.0	1.8	2.5	1.4	-1.2	1.6	1.5	1.0	-1.3
Loneliness, isolation	1.2	1.7	2.0	1.4	-1.2	1.4	1.4	1.2	-1.3
Long-standing illness, disability or infirmity	2.3	3.5	4.3	1.9	-1.7	2.1	1.9	1.8	-1.7
Ever had bowel cancer screening	0.7	0.8	1.2	-0.9	0.7	-0.7	-0.8	-1.1	1.1
Diabetes diagnosed by doctor	1.1	1.8	2.2	-1.4	1.4	-1.1	-1.4	-1.3	1.5
Ever had stillbirth, spontaneous miscarriage or termination	2.8	2.9	3.2	1.7	-1.6	1.7	1.8	1.7	-1.8
Friendships satisfaction	0.1	0.1	0.2	0.2	-0.4	0.5	0.4	0.2	-0.2
Qualifications: nursing, teaching	0.7	1.2	1.4	-1.1	1.1	-1.0	-1.1	-1.1	1.2
Commuting to job workplace: Walk	0.7	0.8	0.8	0.9	-0.7	0.9	0.9	0.9	-0.9
Eye problems/disorders: Cataract	0.8	0.9	1.0	-1.0	0.8	-0.9	-1.0	-0.9	1.0
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	2.5	1.4	-1.6	1.3	1.4	1.1	-1.4
Medication for cholesterol	0.0	0.0	0.1	0.2	-0.2	0.3	0.2	0.2	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.1	0.9	-1.0	0.9	0.9	0.8	-0.8
Back pain experienced in last month	1.0	1.5	1.7	1.3	-1.1	1.3	1.3	1.2	-1.2
Mineral and other dietary supplements	0.4	0.5	0.6	0.7	-0.7	0.6	0.7	0.7	-0.8
Breast cancer (self-reported)	8.3	9.8	10.6	3.1	-3.2	3.0	3.1	3.3	-3.1
Asthma (self-reported)	6.9	13.8	14.5	3.8	-3.4	3.7	3.8	3.8	-3.8
Osteoporosis (self-reported)	0.4	0.5	0.6	-0.7	0.7	-0.8	-0.7	-0.8	0.7
Osteoarthritis (self-reported)	0.5	0.6	0.9	-0.8	1.0	-0.7	-0.7	-0.8	0.8
Medication: Aspirin	0.1	0.2	0.3	-0.4	0.4	-0.2	-0.4	-0.5	0.6
Medication: Gliclazide	3.0	3.4	3.7	-1.9	1.8	-1.7	-1.9	-1.8	1.9
Illnesses of father: None of the above (group 1)	2.2	2.7	2.9	-1.6	1.7	-1.5	-1.6	-1.7	1.7
Smoking status: Current	0.2	0.3	0.5	-0.5	0.6	-0.7	-0.5	-0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	1.9	1.0	-1.0	1.0	1.0	1.4	-1.1
Whole body water mass	1.5	8.3	9.2	-2.9	2.9	-2.7	-2.8	-3.0	3.0
Leg predicted mass (right)	0.8	4.3	4.7	-2.0	2.1	-2.0	-2.0	-2.2	2.1
Arm fat mass (left)	0.7	2.7	3.2	1.7	-1.3	1.8	1.8	1.7	-1.6
Number of self-reported non-cancer illnesses	0.7	1.3	1.8	1.2	-0.9	1.4	1.2	0.9	-1.0
Average weekly champagne plus white wine intake	0.6	0.8	1.3	-0.9	0.9	-1.2	-0.9	-0.8	0.7
Miserableness	0.1	0.1	0.3	0.4	-0.2	0.5	0.4	0.1	-0.1
Guilty feelings	0.6	0.9	1.2	1.0	-0.9	1.0	1.1	0.8	-1.0
Wears glasses or contact lenses	0.3	0.3	0.5	0.5	-0.6	0.5	0.5	0.7	-0.7
Ever taken oral contraceptive pill	1.9	2.1	2.4	-1.4	1.5	-1.4	-1.4	-1.6	1.4
Hearing aid user	0.2	0.3	0.6	0.5	-0.4	0.5	0.4	0.8	-0.5
Mother’s age at death	3.3	4.2	4.7	-2.0	2.2	-1.9	-2.0	-2.1	2.1
Financial situation satisfaction	0.0	0.0	0.1	0.1	-0.1	0.4	0.2	0.1	0.0
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	0.5	-0.8	0.7	0.5	0.5	-0.3
Commuting to job workplace: Public transport	0.1	0.1	0.1	-0.2	0.2	-0.2	-0.3	-0.3	0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.3	0.5	-0.4	-0.2	-0.2	0.1
Medication: Blood pressure	0.0	0.0	0.1	-0.0	0.3	-0.1	-0.0	-0.1	0.0
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	0.1	0.3	0.2	-0.0	0.1	0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.5	0.7	-0.5	0.7	0.7	0.7	-0.6
High cholesterol (Self-reported)	1.1	1.9	2.3	-1.4	1.3	-1.2	-1.4	-1.5	1.5
Medication: Bendroflumethiazide	0.0	0.0	0.0	0.0	0.1	-0.1	0.1	-0.0	-0.1
Medication: Paracetamol	0.0	0.0	0.1	0.0	0.0	-0.1	-0.0	0.2	-0.2
Medication: Lisinopril	0.0	0.0	0.0	0.1	0.1	0.1	0.1	0.0	-0.1
Medication: Atorvastatin	0.1	0.1	0.2	0.3	-0.2	0.4	0.3	0.4	-0.3
Illnesses of father: High blood pressure	2.9	3.6	4.0	-1.9	2.0	-1.9	-2.0	-1.7	1.8
Alcohol drinker status: Never	0.1	0.1	0.2	-0.2	0.1	-0.1	-0.2	-0.3	0.4
Ever smoked	0.4	0.6	0.8	-0.9	0.8	-0.9	-0.8	-0.8	0.7
Basal metabolic rate	1.0	5.7	6.4	-2.4	2.4	-2.2	-2.3	-2.5	2.5
Leg fat percentage (left)	3.2	11.6	12.7	3.5	-3.0	3.5	3.6	3.5	-3.4
Arm fat-free mass (left)	0.7	3.8	4.5	-1.9	1.9	-1.8	-1.9	-2.0	2.1
Number of operations (self-reported)	2.2	3.3	3.4	1.9	-1.8	1.8	1.8	1.8	-1.8
Average weekly beer plus cider intake	0.6	0.9	1.2	1.0	-0.7	1.1	1.1	0.8	-0.8
Irritability	0.0	0.0	0.1	0.1	0.1	0.3	0.1	-0.3	0.2
Risk taking	0.0	0.0	0.1	0.1	0.1	0.2	0.2	0.1	-0.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.1	-0.9	0.6	-0.7	-0.9	-0.9	1.0
Fractured/broken bones in last 5 years	1.3	1.6	1.9	1.4	-1.1	1.4	1.3	1.2	-1.3
Age started oral contraceptive pill	0.2	0.2	0.5	0.5	-0.7	0.4	0.5	0.5	-0.4
Diastolic blood pressure, automated reading	0.1	0.4	0.6	0.6	-0.2	0.8	0.7	0.6	-0.6
Ever depressed for a whole week	0.3	0.4	0.6	0.6	-0.8	0.8	0.6	0.4	-0.4
Unable to work because of sickness or disability	6.7	8.6	9.1	3.0	-2.7	3.0	3.0	2.9	-3.0
Commuting to job workplace: Cycle	0.0	0.0	0.0	-0.0	-0.2	-0.1	-0.1	-0.1	0.1
Myopia	0.0	0.0	0.1	0.1	-0.3	0.0	0.0	0.3	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.3	0.9	-1.1	0.7	0.8	1.0	-1.0
Cholesterol lowering medication	0.4	0.6	0.8	0.8	-0.8	0.9	0.8	0.5	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.9	0.8	-0.9	0.7	0.8	0.6	-0.8
Pain experienced in last month	0.1	0.1	0.2	-0.4	0.2	-0.4	-0.4	-0.3	0.4
Supplements: Calcium	0.1	0.1	0.1	0.3	-0.4	0.2	0.2	0.2	-0.1
Basal cell carcinoma (self-reported)	3.2	3.8	4.5	1.9	-2.1	1.9	1.8	2.1	-1.9
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.3	0.4	-0.2	0.5	0.5	0.5	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	1.3	-1.1	1.1	-1.1	-1.1	-1.2	1.1
Heart disease (siblings)	1.4	1.7	2.3	1.3	-1.1	1.5	1.4	1.2	-1.1
Alcohol drinker status: Previous	3.9	4.4	5.4	2.1	-2.2	1.9	1.9	2.3	-2.1
Pack years of smoking	1.2	1.7	2.1	1.3	-1.2	1.2	1.3	1.5	-1.4
Impedance of whole body	0.1	0.7	1.0	0.8	-0.9	0.6	0.7	1.0	-1.0
Leg fat mass (left)	0.9	3.4	4.0	1.9	-1.4	2.0	2.0	1.9	-1.8
Arm predicted mass (left)	0.7	3.4	4.0	-1.8	1.8	-1.7	-1.8	-1.9	2.0