Hub : Genes

GHRL

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2850	0.0950	1.7e-03	0.093	NA	0.112	NA	0.097	1.1e-03	NA	3.5e-04	NA	8.6e-04
2	GTEx	Brain Cortex	0.4500	0.1210	1.6e-03	0.099	NA	0.016	NA	0.110	1.1e-03	NA	1.1e-01	NA	6.0e-04
3	GTEx	Esophagus Muscularis	0.1390	0.0480	6.8e-04	0.076	NA	0.078	NA	0.080	2.3e-05	NA	1.8e-05	NA	1.4e-05
4	GTEx	Liver	0.5390	0.1220	6.1e-04	-0.006	NA	-0.002	NA	-0.002	5.0e-01	NA	3.8e-01	NA	3.7e-01
5	GTEx	Nerve Tibial	0.1118	0.0348	1.5e-04	0.089	NA	0.113	NA	0.118	7.5e-07	NA	2.3e-08	NA	1.1e-08
6	GTEx	Prostate	0.3050	0.1250	4.1e-03	-0.003	NA	0.020	NA	-0.001	3.9e-01	NA	1.0e-01	NA	3.5e-01
7	GTEx	Thyroid	0.1740	0.0540	1.0e-04	0.023	NA	0.041	NA	0.050	6.2e-03	NA	4.0e-04	NA	1.0e-04
8	NTR	Blood	0.0433	0.0132	6.4e-05	0.008	0.020	0.024	0.024	0.019	1.2e-03	2.5e-07	2.9e-08	2.0e-08	5.1e-07
9	YFS	Blood	0.0919	0.0190	0.0e+00	0.094	0.059	0.093	0.089	0.093	4.1e-29	8.9e-19	1.1e-28	1.1e-27	7.6e-29
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0515	0.0256	1.8e-03	0.018	0.025	0.018	NA	0.011	3.6e-03	7.6e-04	3.6e-03	NA	1.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.6	1.0	2.8	0.6	1.2	-1.1	-0.5	1.7	0.1	1.0	-0.4	-1.6	0.2
Bipolar Disorder or Schizophrenia	0.8	2.0	4.4	1.6	1.5	-0.8	0.5	1.7	0.9	2.1	-0.0	-2.1	-1.2
Depressed Affect (Nagel 2018)	2.0	4.3	12.3	1.3	3.2	3.5	-0.8	-0.1	2.1	2.9	-1.6	-1.1	1.2
Depression (Nagel 2018)	1.2	1.7	5.9	1.5	2.4	1.6	-0.5	0.3	1.1	1.4	-1.3	-0.9	0.6
Intelligence (Savage-Jansen 2018)	0.8	2.4	6.5	-1.3	-1.3	-1.9	-1.2	-0.6	-2.5	-2.5	1.3	1.1	0.3
Neuroticism (Nagel 2018)	1.0	2.4	7.9	1.1	1.9	2.8	-0.8	-0.7	0.7	2.1	-1.5	-0.5	1.5
Schizophrenia (2018)	0.7	1.5	3.4	1.5	1.0	-0.1	1.1	0.9	1.1	1.8	0.3	-1.4	-1.7
Schizophrenia vs Biploar Disorder	0.4	0.5	1.3	-0.1	-0.6	0.4	1.0	-0.9	-0.0	-0.1	1.0	1.1	-0.6
Worry (Nagel 2018)	0.3	0.7	1.7	0.5	0.5	1.3	0.6	-0.7	0.5	0.9	-1.2	0.3	1.2
Alzheimer’s Disease (in mother)	0.4	0.5	1.6	-0.1	0.5	-0.5	-0.6	-1.0	0.5	-0.0	-1.0	0.2	1.3
Alzheimer’s Disease (in father)	0.6	0.7	4.4	-0.5	-0.6	0.5	-0.1	-0.2	-0.5	0.3	0.8	0.8	-2.1
Alzheimer’s Disease (including proxy)	0.3	0.4	1.4	-0.2	0.6	0.3	-0.7	-1.1	0.3	-0.1	0.2	1.2	-0.5
Crohns Disease (2017)	0.5	1.1	5.8	0.9	-0.1	-1.2	-0.5	0.9	0.3	0.5	-1.2	0.1	2.4
Irritable Bowel Disease (IBD)	0.4	1.0	2.3	-0.7	-1.5	-1.4	-1.2	-0.4	-0.2	-0.7	-0.5	0.4	1.5
Ulcerative Colitis (UC)	0.7	1.3	4.8	-1.6	-2.2	-1.2	-1.2	-1.1	-0.7	-1.2	0.1	0.1	0.0
Major Depression (MDD)	0.3	0.4	1.8	-0.1	-0.7	0.1	0.2	0.7	1.3	0.8	0.4	-0.7	0.4
Reaction Time	0.2	0.5	2.0	0.6	0.6	-0.7	0.3	0.1	1.0	-0.3	-0.5	-0.2	1.4
Verbal and Numeric Reasoning (VNR)	0.9	2.2	6.0	-1.5	-1.4	-1.5	-1.1	-1.2	-2.5	-2.3	0.6	1.1	0.8
Breast Cancer	0.5	1.2	3.1	-0.4	-0.7	0.0	0.4	0.1	-1.3	-1.3	1.6	1.8	-1.3
Ovarian Cancer	3.6	4.8	9.4	-2.4	-2.8	-3.1	-0.5	-2.7	-0.8	-2.7	-0.1	1.9	2.4
Prostate Cancer	0.7	1.0	3.1	0.2	0.3	-1.4	0.6	0.5	-0.7	-1.1	1.2	0.9	-1.8
Age at First Birth	1.2	1.7	4.7	-1.3	0.1	-0.2	-0.6	-0.8	-1.4	-1.9	2.2	1.7	-1.1
Bipolar Disorder (2011)	2.3	2.2	10.0	2.1	-0.4	-0.5	1.1	1.2	0.7	1.3	-1.6	-3.2	-0.1
Body Mass Index (BMI) (2010)	0.5	0.7	2.9	0.4	-0.0	-0.1	0.4	-0.0	0.6	0.1	-1.7	-0.8	1.6
Coronary Artery Disease (CAD)	0.5	0.6	1.9	0.4	-0.9	-1.2	-0.3	1.4	0.5	0.3	0.9	-0.6	-0.2
Crohns Disease (2012)	0.4	0.6	2.7	0.0	0.5	-0.2	-1.6	0.5	-1.0	0.2	0.4	0.7	0.9
Mean Putamen Volume	0.3	0.4	1.7	-0.2	1.3	0.1	-0.4	-0.5	0.0	-0.5	0.4	1.0	-0.4
Fasting Glucose	0.3	0.3	0.9	-0.3	0.2	-0.2	-0.3	-0.0	-0.9	-0.6	1.0	0.9	-0.6
HbA1C	0.8	0.9	3.8	0.5	1.2	1.9	0.9	0.6	0.3	1.1	0.7	0.5	-0.8
HDL Cholesterol	1.2	1.9	3.8	-1.8	-1.6	-2.0	0.2	-1.6	-0.4	-1.7	1.1	1.1	-1.1
LDL Cholesterol	0.5	0.8	2.8	-1.0	0.3	0.9	-0.1	-1.7	0.7	-0.6	0.5	1.2	0.7
Lupus	0.5	0.8	4.3	-0.3	-0.3	-0.6	0.9	0.3	0.9	0.5	0.7	-0.9	-2.1
Neuroticism (2016)	1.4	2.0	6.9	1.5	2.1	2.6	-1.1	0.1	0.5	2.2	0.5	-0.3	0.2
Primary Biliary Cirrhosis	1.5	2.1	6.8	-1.5	1.5	0.1	-0.1	1.2	-0.4	-0.2	2.6	1.2	-2.6
Rheumatoid Arthritis	0.3	0.4	2.2	-0.1	-0.2	-0.2	1.5	0.0	0.8	-0.4	-0.5	-0.5	-0.5
Schizophrenia (2014)	0.2	0.5	1.9	0.5	0.2	-1.0	0.7	-0.3	-0.2	0.5	0.7	-0.6	-1.4
Triglycerides	0.3	0.4	1.5	-0.2	0.7	1.2	0.2	0.8	0.8	0.8	0.3	-0.7	0.2
Type 2 Diabetes (T2D) (2012)	2.0	2.3	5.8	-1.7	-0.7	-0.3	-0.3	-2.2	-0.2	-2.4	-0.3	2.0	2.0
Ulcerative Colitis	0.9	1.3	2.2	-1.3	-1.5	-1.4	-1.5	-1.0	-1.3	-1.2	0.7	0.1	-0.2
Blood Eosinophil Count	0.6	4.6	18.7	1.0	-4.3	-2.1	-0.3	-1.7	-0.0	0.8	-3.1	-2.9	-0.9
Blood Platelet Count	0.1	1.5	4.0	-1.4	-0.9	-1.0	-1.0	-1.6	-0.4	-2.0	1.6	0.9	0.7
Blood Red Count	0.1	1.0	2.1	1.0	0.6	0.3	0.7	0.5	1.4	0.3	-1.4	-1.1	1.5
Blood White Count	0.1	0.6	2.0	-0.6	0.4	0.9	-0.3	-0.3	-0.3	-0.9	1.4	0.3	-1.2
Heel T-Score	0.1	1.1	2.3	1.0	1.2	-0.1	0.2	1.4	1.5	1.5	-0.3	-1.0	0.8
BMI	0.4	2.6	5.4	1.4	2.3	2.0	1.1	1.8	1.4	0.1	-1.8	-1.0	2.0
Height	0.4	7.0	30.0	-0.1	-1.9	-1.6	0.2	-2.5	0.3	-1.4	-5.0	-0.2	5.5
Waist Hip Ratio (WHR)	0.3	1.5	2.7	-1.5	-1.2	-0.4	-1.6	-1.4	-0.4	-1.6	0.9	0.8	1.5
Systolic Blood Pressure	0.7	3.6	9.2	0.8	2.2	3.0	1.8	1.8	-0.5	1.5	1.8	-0.6	-2.9
Smoking Status	1.0	2.3	4.5	1.4	0.6	1.2	0.0	1.8	2.1	2.1	-1.5	-2.0	0.7
Allergy or Eczema	0.2	0.7	1.9	0.6	1.2	-0.8	0.2	1.4	0.6	0.5	0.3	-1.2	-0.3
Cardiovascular Disease	1.1	3.6	16.9	0.6	4.1	3.2	0.8	0.6	-1.1	-0.4	2.1	1.2	0.0
Hypothyroidism (self reported)	0.8	1.7	6.7	-1.1	-2.6	-2.4	-0.4	-0.9	-0.9	-1.2	-0.3	0.2	0.6
Respiratory disease	0.5	1.0	4.3	0.0	0.1	-0.8	-0.1	1.3	-0.4	-0.5	2.1	0.3	-1.8
Type 2 Diabetes (T2D) (2018)	1.0	1.8	6.8	1.1	0.4	1.8	0.7	1.5	2.6	1.3	-0.7	-1.1	-0.5
Lung FEV1/FVC ratio	0.1	0.4	1.4	-1.2	0.0	-0.6	-0.2	-0.2	-1.1	-0.4	0.2	0.5	-0.4
Lung FVC	0.2	0.8	4.1	0.6	0.5	1.1	-0.7	0.7	0.5	0.4	2.0	0.4	-0.8
Neuroticism	0.7	1.6	4.8	0.2	1.6	2.2	-0.7	-1.1	0.8	1.2	-1.2	0.4	1.9
Chronotype (morning person)	0.0	0.1	0.4	0.1	-0.1	-0.0	-0.7	-0.1	0.4	-0.1	0.5	-0.3	-0.2
Hair Pigment	0.1	2.1	5.8	0.7	1.1	1.2	1.9	2.4	1.4	1.1	-0.8	-0.9	-1.8
Tanning	0.2	2.4	7.1	1.3	-0.8	0.2	1.0	0.8	1.8	1.7	-2.2	-2.7	1.2
Hand grip strength (left)	0.3	0.9	4.1	0.3	0.7	0.2	0.2	1.1	-1.2	-0.2	2.0	0.9	-1.0
Number of treatments/medications taken	1.0	1.9	5.5	1.4	-0.1	2.3	0.5	1.5	0.1	1.9	-1.2	-1.8	0.8
Average weekly spirits intake	0.4	0.5	1.7	1.3	0.2	0.3	0.7	0.6	0.2	1.3	-0.3	-0.8	0.4
Sensitivity / hurt feelings	0.8	1.4	4.8	1.1	-0.7	2.2	0.2	-0.9	0.9	1.4	-1.4	-0.5	1.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.9	-0.1	1.4	0.9	-1.1	-0.7	-0.3	0.3	-0.8	0.4	0.7
Hearing difficulty/problems: Yes	1.0	1.5	5.5	0.0	0.2	1.9	-1.2	-1.1	-0.2	-0.9	0.6	1.5	2.3
Relative age of first facial hair	0.6	1.3	3.5	-1.5	-0.4	-0.7	-1.6	0.2	0.3	-0.5	1.9	1.0	-1.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	2.0	-0.0	0.2	0.9	-1.4	-0.9	0.3	0.4	-0.5	-0.6	1.1
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.3	-0.5	-0.0	-0.4	-0.1	0.1	0.1	1.2	-1.3	-1.3	1.5
Ever had hysterectomy (womb removed)	0.7	0.8	2.7	0.5	0.0	1.3	1.1	1.7	0.7	1.2	0.0	-0.2	0.2
Systolic blood pressure, automated reading	0.8	2.2	4.5	1.4	0.8	1.8	0.8	1.6	1.7	2.1	-0.1	-1.9	-1.4
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	4.2	1.4	-0.7	2.0	0.8	0.8	1.1	1.1	-1.0	-0.9	1.3
Angina	1.4	1.8	3.9	1.9	1.6	2.0	-0.4	1.2	0.9	1.0	-1.2	-0.6	1.6
Medication for hormone replacement therapy	0.2	0.3	1.6	0.0	0.5	-1.2	0.3	-0.0	-0.3	-0.2	0.1	-0.3	-0.7
Vitamin and mineral supplements	0.4	0.6	3.3	-0.8	1.8	0.3	-0.8	0.4	0.8	-0.4	0.4	0.5	0.4
Supplements: Zinc	0.5	0.5	1.8	-0.1	0.9	0.2	0.9	-0.5	-1.4	-0.3	0.4	1.1	-0.2
Medication: Co-codamol	1.2	1.4	6.3	1.4	-2.5	0.3	1.4	0.7	0.1	0.6	-1.2	-1.1	-0.2
Medication: Metformin	0.5	0.7	2.5	0.2	-0.1	0.5	0.7	1.0	1.6	0.9	-0.4	-1.1	-0.2
Diabetes (father)	0.4	0.4	1.6	-1.1	1.3	-0.7	-0.3	-0.1	0.0	-0.3	-0.1	0.8	-0.6
Diabetes (mother)	0.8	1.1	5.0	0.7	0.6	-0.0	-0.7	1.9	0.2	-0.1	2.2	0.9	0.1
Severe depression (siblings)	0.5	0.5	1.9	0.9	-0.3	1.4	0.9	0.5	0.8	0.7	-0.3	-0.4	0.4
Pack years adult smoking proportion	0.6	0.8	3.3	1.3	1.8	0.6	-1.4	-0.3	0.8	0.5	0.2	-0.4	0.3
Impedance of leg (right)	0.3	1.6	4.1	-1.0	-1.9	-2.0	-1.0	-1.3	-0.9	-0.6	1.6	0.8	0.2
Leg fat-free mass (left)	0.4	2.4	9.3	1.2	1.6	1.3	0.6	0.7	0.7	0.0	-3.1	-1.0	2.5
Trunk fat percentage	0.7	2.8	12.1	0.7	1.5	0.6	0.3	0.4	1.2	0.7	-3.5	-1.4	2.9
Hand grip strength (right)	0.3	0.9	4.6	-0.2	0.7	0.2	-0.7	0.9	-0.8	-0.4	2.1	0.8	-0.9
Townsend deprivation index at recruitment	0.8	1.1	4.6	-1.1	-0.2	-0.2	-0.0	-2.1	-1.4	-0.1	-1.1	1.0	-0.8
Current tobacco smoking	0.8	1.4	3.1	1.0	1.2	1.8	-0.6	1.0	1.5	1.5	-0.0	-1.5	-0.2
Average weekly fortified wine intake	0.7	0.8	1.5	0.5	-1.2	-0.9	1.0	-0.6	-0.8	-0.8	1.2	1.2	-0.2
Maternal smoking around birth	0.4	0.5	2.5	0.7	-0.0	1.6	0.5	-0.4	0.2	0.7	-0.6	0.1	1.0
Fed-up feelings	0.8	1.5	6.1	0.9	0.4	2.5	-1.0	-1.0	0.7	1.2	-1.0	-0.4	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.9	0.9	1.7	1.1	0.1	-0.2	1.1	1.0	-1.5	-0.6	0.8
Relative age voice broke	0.6	0.9	2.2	-0.9	-0.1	-0.3	-1.1	1.1	1.2	0.3	1.3	0.7	-1.5
Taking other prescription medications	1.3	2.1	4.9	1.4	-0.5	2.1	-0.1	1.3	1.3	2.2	-1.1	-2.2	0.1
Age when periods started (menarche)	0.7	1.7	4.7	-1.6	-0.1	-1.9	-0.7	-1.5	-1.3	-2.2	0.4	1.2	-0.1
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	3.4	1.5	0.6	1.5	0.8	1.5	1.2	1.9	-0.2	-0.8	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.8	0.3	0.4	1.0	-0.1	1.3	1.2	0.3	0.9	0.4	0.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	3.3	0.7	-0.2	1.4	0.2	0.1	0.2	0.4	-0.9	-0.9	-1.8
Qualifications: CSEs or equivalent	1.0	1.4	4.3	1.2	0.8	2.1	0.3	1.3	0.6	1.6	1.0	-0.9	-1.0
Serious illness, injury or assault to yourself	3.3	4.0	11.1	2.3	-0.2	1.6	-0.0	2.4	1.3	2.9	-2.3	-3.3	-0.2
High blood pressure	0.7	1.8	9.9	0.5	2.2	3.1	0.1	0.3	0.4	0.8	1.3	-0.5	-0.7
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.2	0.0	0.8	-1.1	-0.1	0.8	0.3	-0.4	0.5	-0.5	-0.1
Multivitamins +/- minerals	0.9	1.1	7.9	0.5	-2.8	-0.2	0.6	-0.9	-1.1	-0.4	-0.2	-0.0	0.4
Stomach or abdominal pain in last month	0.9	1.1	3.3	-1.2	-0.1	-1.4	1.2	0.2	0.4	-1.8	0.8	1.2	-0.7
Supplements: Glucosamine	0.3	0.4	2.0	-0.1	0.0	0.2	0.3	0.2	-1.4	0.5	-0.5	-0.0	1.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.8	-0.5	-0.8	-0.4	-0.0	-1.3	0.8	-0.8	-0.5	0.3	0.2
Medication: Atenolol	0.6	0.7	1.8	-0.5	0.7	1.2	-1.3	-0.2	1.1	1.2	0.1	-0.2	0.3
Medication: Levothyroxine sodium	0.3	0.5	2.6	0.1	-0.9	-0.3	0.0	-0.7	0.2	-0.4	-1.6	-0.7	-0.3
Sitting height	0.3	2.3	8.2	-0.9	-1.2	-0.6	-0.1	-1.8	-0.2	-1.0	-2.7	-0.1	2.9
Chronic bronchitis/emphysema (father)	0.6	0.7	1.7	0.4	-1.1	-0.8	0.4	0.3	0.8	0.7	-1.3	-0.9	1.2
High blood pressure (mother)	0.8	1.1	3.2	-0.5	1.8	-0.2	-0.5	0.2	-1.2	-0.8	1.6	1.6	-0.0
Body mass index (BMI)	0.8	3.3	6.0	1.7	2.4	2.4	0.5	1.7	1.6	1.1	-2.3	-1.5	2.0
Impedance of leg (left)	0.3	1.5	3.6	-1.1	-1.9	-1.9	-1.0	-1.5	-0.5	-0.5	1.6	0.8	-0.0
Leg predicted mass (left)	0.5	2.4	9.4	1.2	1.6	1.3	0.5	0.7	0.7	0.0	-3.1	-1.0	2.5
Trunk fat mass	0.8	3.3	13.0	0.9	1.7	0.9	0.3	0.5	1.3	0.5	-3.6	-1.4	3.4
Waist circumference	0.7	2.4	7.8	0.6	1.8	1.1	0.2	0.5	1.4	0.1	-2.8	-1.2	2.8
Number of incorrect matches in round	1.7	2.8	5.1	1.9	2.1	1.3	1.5	2.2	-0.3	1.9	-0.2	-2.2	-1.4
Past tobacco smoking	0.1	0.2	0.6	0.3	-0.4	0.4	0.8	-0.2	-0.8	-0.4	0.2	0.5	-0.6
Alcohol usually taken with meals	0.4	0.6	2.0	0.9	-0.6	0.8	0.1	0.9	0.4	-0.2	-0.9	-0.2	1.4
Nervous feelings	0.2	0.4	2.0	0.0	-0.0	1.4	0.0	-0.7	0.8	0.9	-0.0	0.3	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.7	2.0	1.2	2.2	-0.6	0.6	-0.1	1.6	-0.6	-0.1	0.2
Hearing difficulty/problems with background noise	2.1	3.4	10.9	-1.6	1.0	1.1	-2.2	-1.6	-0.5	-1.6	1.8	3.3	2.1
Hair/balding pattern: Pattern 2	0.8	1.0	3.0	0.7	0.7	-0.6	1.7	1.1	-0.2	0.6	0.2	-1.2	-1.7
Had menopause	0.8	1.0	2.4	0.5	-1.0	1.1	0.7	1.5	1.2	1.4	0.4	-0.5	1.0
Had other major operations	0.2	0.3	1.0	0.1	-0.2	-0.3	-1.0	1.0	0.8	0.2	0.3	-0.1	-0.3
Forced vital capacity (FVC)	0.1	0.4	1.1	0.6	-0.7	0.2	-1.0	0.2	-0.1	-0.6	1.1	0.8	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	2.0	1.0	0.4	1.4	0.0	1.0	1.0	0.6	-0.0	0.0	0.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.6	-0.1	1.3	0.8	-0.9	-0.2	0.6	0.8	-0.9	-1.0	1.1
Qualifications: None of the above	0.7	1.4	5.0	1.3	1.1	1.3	-0.0	0.5	1.4	2.2	-0.9	-1.1	0.4
Financial difficulties in last 2 years	1.0	1.3	5.3	0.1	0.1	1.2	-0.1	1.3	-0.9	1.6	1.3	-0.2	-2.3
Mouth/teeth dental problems	0.5	0.7	2.5	0.8	-0.0	-1.6	-0.1	1.1	-0.6	0.4	0.1	-1.4	-0.6
Heart attack	0.5	0.6	3.3	0.0	0.0	-0.5	0.6	0.2	0.2	0.8	-1.8	-1.2	-0.3
Allergy	0.2	0.6	2.3	-0.3	-0.4	0.4	-0.4	-1.5	-1.0	-0.2	-0.8	0.8	0.7
Pain all over the body in last month	1.0	1.1	5.0	0.2	-0.9	1.3	0.2	-0.8	1.3	-0.1	-0.9	0.3	2.2
Diabetes (self-reported)	0.9	1.4	4.3	0.8	-0.1	1.0	0.2	1.4	2.1	1.2	-1.4	-1.5	0.2
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	3.9	-1.5	-0.4	-1.8	-2.0	-1.1	-1.0	-1.8	0.7	1.2	1.2
Medication: Ramipril	0.5	0.6	2.3	0.9	0.4	0.5	0.8	1.1	-0.2	0.2	-0.7	-1.5	0.0
Medication: Simvastatin	1.3	2.0	4.1	1.4	1.7	1.8	1.1	2.0	0.4	1.6	0.2	-1.0	-1.6
Fluid intelligence score	1.0	2.1	6.2	-1.4	-0.9	-2.5	-1.6	0.3	-1.9	-1.6	0.0	1.3	1.2
Illnesses of siblings	2.8	3.9	8.8	-2.9	-0.6	-3.0	0.6	-2.7	-2.4	-2.6	0.0	1.1	0.2
Neuroticism score	0.8	1.7	7.1	0.3	0.4	2.1	-0.5	-1.4	0.6	0.7	-1.2	0.6	2.7
Weight	0.7	3.3	11.3	1.4	1.8	1.7	0.3	0.6	1.1	0.3	-3.4	-1.1	3.2
Impedance of arm (right)	0.6	3.0	9.4	-2.4	-1.6	-3.1	-0.7	-2.7	-1.6	-0.9	0.1	1.0	-0.5
Arm fat percentage (right)	0.6	2.2	7.3	0.9	2.2	1.1	0.6	0.8	1.0	1.0	-2.7	-1.4	1.6
Trunk fat-free mass	0.3	1.5	6.3	1.0	0.8	1.8	0.1	0.2	0.6	-0.3	-1.8	-0.3	2.5
Hip circumference	0.7	3.1	13.2	1.0	1.7	1.1	0.5	0.9	0.7	0.2	-3.6	-1.0	3.1
Time employed in main current job	0.3	0.4	1.5	0.2	1.0	-0.3	0.0	1.2	-0.3	0.8	0.0	-0.6	-0.1
Alcohol intake versus 10 years previously	3.0	4.5	11.8	1.7	1.3	1.2	1.4	3.4	2.1	3.1	0.1	-2.6	-2.2
Father’s age at death	0.5	0.6	2.5	-0.2	0.4	-1.2	-0.4	0.3	-0.2	-0.1	-1.2	0.4	1.6
Worrier / anxious feelings	0.4	0.7	2.8	-0.4	-0.3	1.1	-0.3	-1.1	-0.1	-0.4	-0.3	1.2	1.7
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	4.4	1.3	2.1	0.4	-0.7	0.6	-0.4	0.8	-0.8	-1.6	0.2
Falls in the last year	1.0	1.4	3.6	-1.6	-0.8	0.6	-1.9	-1.3	-1.1	-0.3	1.1	1.3	0.9
Hair/balding pattern: Pattern 3	0.2	0.2	0.9	1.0	0.2	0.4	-0.1	0.1	0.3	0.0	-0.8	-0.3	0.7
Number of live births	0.4	0.6	1.8	-0.4	0.3	0.3	1.3	-0.6	1.2	-0.3	0.3	1.0	-0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.7	0.4	-0.5	0.2	-0.4	0.5	-0.5	-0.3	0.8	0.5	0.2
Pulse rate	1.2	2.1	5.2	-1.0	-1.0	-0.8	-0.1	-1.1	-2.3	-2.1	1.6	2.1	-0.6
Happiness	0.4	0.4	1.1	-0.0	0.1	-0.3	-0.6	-0.0	0.4	0.9	-0.9	-0.9	1.1
Noisy workplace	1.1	1.3	5.3	1.1	0.4	0.9	0.8	1.1	1.1	1.6	-0.3	-2.3	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.2	0.2	-1.1	-0.8	0.1	0.5	-1.1	-0.6	0.7	0.6	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	6.6	-0.4	-0.5	-2.6	-0.1	0.9	-0.0	-0.6	-0.9	-1.1	0.7
Mouth/teeth dental problems: Dentures	1.3	2.1	4.9	1.6	1.1	2.2	0.1	1.4	2.2	2.1	-0.4	-1.1	0.3
Asthma	0.3	0.7	2.6	0.2	-0.1	-0.8	0.0	1.2	-1.0	-0.2	0.9	-0.4	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.8	0.6	0.6	0.6	-0.7	1.7	-1.0	1.1	0.1	-0.3	-0.5
Medication: Cholesterol lowering	1.4	2.1	4.5	1.6	0.9	1.9	2.1	0.9	-0.0	1.8	-1.7	-1.8	-0.0
Depression (self-reported)	0.3	0.4	1.2	0.9	0.8	1.1	-0.2	-0.5	0.2	-0.0	-0.7	-0.6	0.6
Medication: Lansoprazole	0.8	1.0	2.0	0.7	1.1	1.0	-1.1	0.5	1.3	0.9	1.0	0.1	-1.4
Prospective memory result	1.0	1.3	3.7	1.9	-0.7	1.0	0.6	0.7	-0.5	1.3	-1.1	-1.6	1.1
Lung cancer (father)	0.5	0.6	4.1	-0.5	-2.0	0.6	-0.1	-0.7	0.4	0.1	-0.1	0.4	0.6
Illnesses of mother	0.7	0.9	2.3	-1.0	-0.4	-1.4	-0.5	-1.5	-0.7	-1.5	-0.1	0.6	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.9	0.8	0.3	0.3	-0.2	0.9	-0.5	0.5	0.6	-0.4	-0.4
Pulse wave Arterial Stiffness index	0.2	0.2	0.8	0.9	0.0	-0.3	-0.0	0.4	-0.2	0.1	0.8	-0.1	-0.0
Impedance of arm (left)	0.8	3.8	9.8	-2.9	-1.7	-3.1	-1.1	-3.0	-1.6	-1.5	0.3	1.4	-0.1
Arm fat mass (right)	0.7	3.0	9.7	1.2	1.9	1.6	0.6	1.0	1.5	1.0	-3.1	-1.7	2.3
Trunk predicted mass	0.3	1.5	6.2	1.0	0.8	1.9	0.1	0.2	0.7	-0.2	-1.8	-0.3	2.5
Standing height	0.3	2.5	10.4	-0.3	-1.2	-1.0	-0.5	-1.9	-0.6	-1.5	-2.4	0.7	3.2
Length of working week for main job	0.7	0.8	2.7	-0.6	0.6	-0.4	-1.6	-0.4	-0.9	-1.3	-0.4	0.6	0.7
Exposure to tobacco smoke at home	1.5	1.6	5.2	0.9	0.0	0.7	1.3	1.4	1.2	1.3	1.4	-1.0	-2.3
Breastfed as a baby	1.0	1.3	5.1	0.6	0.1	-0.2	1.2	1.2	-1.0	1.2	-0.9	-2.3	-1.0
Tense / ‘highly strung’	0.7	1.1	4.5	2.1	0.5	0.9	0.3	0.4	1.2	1.4	-0.7	-1.2	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.2	-0.2	-0.5	0.3	-0.8	-0.7	-0.4	-0.4	0.7	1.1	1.5
Hair/balding pattern: Pattern 4	0.2	0.6	2.6	-0.7	0.8	1.6	0.1	0.1	-0.2	0.8	-0.4	1.0	-0.4
Birth weight of first child	0.7	1.4	4.9	0.1	-1.1	-0.2	0.3	-2.0	-0.3	-0.9	-2.2	0.6	1.4
Peak expiratory flow (PEF)	0.0	0.1	0.4	-0.6	-0.2	-0.3	0.5	0.1	-0.0	-0.2	-0.2	0.2	-0.5
Pulse wave reflection index	0.4	0.5	1.3	1.0	1.1	-0.0	0.5	1.0	0.2	0.3	0.8	-0.2	-0.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.2	1.0	1.0	1.5	-0.1	0.5	0.7	0.8	0.0	-1.0	-0.8
Loud music exposure frequency	0.7	0.8	1.7	-1.3	-0.1	0.8	-0.1	-0.5	1.2	0.6	1.2	0.1	-1.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	4.0	-0.5	-0.8	-0.3	0.8	1.3	-0.3	0.1	1.1	-0.1	-2.0
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	4.1	-0.6	0.7	1.3	1.3	-0.8	-0.4	-0.9	0.9	2.0	-0.4
Blood clot in the leg (DVT)	0.5	0.7	2.5	-0.5	1.6	0.5	0.3	1.3	0.1	0.7	0.7	0.2	-1.1
Medication: Paracetamol	0.7	1.2	3.7	1.2	-1.0	0.6	0.2	1.0	-0.7	1.5	-1.9	-1.4	-0.1
Headache pain in last month	0.5	0.9	3.2	0.9	0.5	0.0	-1.2	1.8	-0.1	1.1	0.9	-0.9	-0.6
Medication for cholesterol, blood pressure or diabetes	1.2	2.1	4.2	-1.7	-0.9	-2.0	-1.5	-1.0	0.1	-1.8	1.1	2.0	0.7
Glaucoma (self-reported)	0.3	0.4	3.0	0.4	-0.2	-0.0	0.0	0.6	0.0	0.0	0.5	-0.4	1.7
Gout (self-reported)	0.7	0.9	3.4	-0.1	-1.0	-0.8	0.9	-0.7	-0.5	-0.0	-1.8	-1.2	-0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.1	-0.7	-0.6	-0.8	-0.3	-0.9	0.1	-0.4	-1.0	-0.4	0.6
Medication: Amlodipine	0.4	0.5	2.1	0.4	0.8	1.3	-0.2	0.2	0.0	0.4	-0.2	-1.5	-0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.9	0.6	-0.1	0.0	0.4	1.4	1.0	0.2	0.3	-0.1	-1.1
Birth weight	0.3	0.7	2.7	-1.0	-1.1	-1.6	-0.2	0.0	0.5	-0.7	-1.1	-0.6	0.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	4.8	-0.0	-0.2	2.2	-0.5	-0.0	0.3	0.6	0.6	0.2	0.5
High blood pressure (siblings)	1.0	1.5	4.8	1.9	1.0	2.2	-0.5	0.6	1.6	1.0	-0.6	-0.6	0.2
Forced vital capacity (FVC), Best measure	0.1	0.2	1.0	1.0	-0.2	0.7	-0.4	0.5	-0.0	0.2	0.7	-0.1	0.0
Body fat percentage	0.6	2.5	8.5	1.0	1.7	1.1	0.3	0.6	1.3	0.9	-2.9	-1.4	2.6
Leg fat percentage (right)	0.6	2.0	4.1	1.3	1.7	1.9	-0.2	1.2	1.3	1.1	-1.5	-1.2	2.0
Arm fat-free mass (right)	0.4	2.0	7.9	1.0	1.1	1.8	0.4	0.7	1.4	-0.2	-2.1	-0.4	2.8
Exposure to tobacco smoke outside home	0.9	1.3	7.2	-0.6	0.5	-0.7	0.4	-0.0	0.9	0.9	-0.5	-1.5	-2.7
Comparative body size at age 10	0.4	1.0	4.1	-0.0	1.2	-0.7	1.0	-0.3	0.9	0.1	-2.0	-1.3	-0.3
Number of full brothers	0.6	0.7	1.6	1.2	0.7	0.8	0.1	0.5	1.2	0.9	-0.4	-0.7	1.3
Worry too long after embarrassment	0.6	1.0	3.2	-0.3	-0.4	0.6	-0.8	-1.8	-1.5	0.3	0.1	0.5	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.8	-0.0	0.6	1.3	0.0	-0.9	-0.3	0.1	0.6	0.4	0.9
Wheeze or whistling in the chest in last year	0.2	0.3	1.1	0.2	0.4	-0.4	-0.2	1.0	0.1	-0.2	1.1	-0.7	0.2
Number of children fathered	1.2	1.4	3.6	-0.3	0.3	1.3	0.6	1.2	1.6	1.5	1.1	-0.9	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.7	-0.3	-0.0	-0.3	0.5	-0.7	-0.8	-0.8	0.1	-0.1	1.3
Age at first live birth	2.3	4.0	9.5	-2.6	0.9	-2.0	-1.6	-1.2	-3.1	-2.5	2.0	2.0	-0.8
Pulse wave peak to peak time	0.3	0.3	1.2	-1.1	-0.1	-0.0	-0.0	-0.6	0.1	-0.3	-1.1	0.1	0.6
Health satisfaction	0.8	1.0	1.8	1.2	0.9	0.7	-0.6	1.1	-0.4	0.8	-1.3	-1.2	1.1
Shortness of breath walking on level ground	0.5	0.6	2.2	-0.7	0.4	-0.7	-0.7	-0.2	0.2	-0.8	0.9	1.0	1.5
Qualifications: College or University degree	1.2	3.9	6.1	-2.0	-1.6	-2.5	-1.4	-1.1	-2.1	-2.5	1.9	2.1	-2.1
Eye problems/disorders: None of the above	0.7	0.8	5.2	-0.3	0.4	-0.3	2.3	0.7	-0.9	-0.5	0.0	0.2	-0.6
Mouth/teeth dental problems: Loose teeth	2.0	2.4	6.7	-1.7	-1.1	-0.9	0.7	-2.5	-0.3	-1.6	-2.6	1.0	1.5
Emphysema/chronic bronchitis	0.7	0.8	2.3	-1.5	-0.3	-0.4	-0.9	-0.5	-0.9	-1.1	0.9	1.2	0.7
Medication for pain relief, constipation, heartburn	2.1	3.6	8.6	-2.5	-0.8	-1.4	0.1	-2.9	0.0	-2.6	2.0	2.8	0.0
Neck or shoulder pain in last month	0.6	0.8	4.4	0.6	-0.2	-0.1	-2.1	0.7	0.2	0.6	-1.3	-0.8	0.4
Medication: Blood pressure	1.4	2.5	6.2	1.8	0.9	2.5	1.1	1.0	-0.0	2.1	-1.3	-2.4	-0.9
Angina (self-reported)	1.1	1.5	3.2	1.7	1.6	1.8	-0.4	1.2	0.8	0.9	-0.9	-0.4	1.4
Migraine (self-reported)	1.1	1.4	3.2	1.8	-0.1	1.3	1.1	0.5	1.4	1.5	-1.6	-1.0	0.2
Medication: Ibuprofen	0.2	0.3	1.1	-0.1	-0.2	0.2	-1.0	0.7	-0.5	0.2	0.1	0.4	-0.7
Medication: Allopurinol	0.7	1.0	6.4	0.3	-0.4	-0.6	1.0	-0.8	0.1	-0.3	-2.5	-1.0	0.2
Medication: Omeprazole	0.2	0.2	0.5	0.3	0.1	-0.4	0.5	0.6	-0.3	0.7	-0.4	-0.7	-0.6
Medication: Seretide 50 evohaler	0.9	1.0	5.0	-0.0	-2.2	-0.3	-1.0	0.2	-0.2	-0.3	-0.0	0.3	2.0
Mean time to correctly identify matches	0.3	0.5	2.4	-0.2	-0.2	0.2	0.5	-0.2	1.6	-0.0	-0.6	-0.2	1.5
Heart disease (mother)	1.5	1.8	4.9	1.3	0.6	0.9	1.8	2.2	1.0	1.5	-1.0	-1.1	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	-0.9	-0.4	-0.5	-1.1	-0.2	-1.1	-0.4	0.9	0.5	-1.0
Whole body fat mass	0.8	3.2	11.4	1.3	1.7	1.3	0.6	0.7	1.4	0.7	-3.4	-1.6	2.9
Leg fat mass (right)	0.8	2.9	7.1	1.6	1.9	1.8	0.1	1.2	1.4	0.9	-2.4	-1.5	2.7
Arm predicted mass (right)	0.4	2.2	7.6	1.2	1.3	1.7	0.4	0.9	1.4	0.1	-2.2	-0.8	2.8
Pulse rate, automated reading	0.5	1.6	3.8	-1.9	-0.6	-0.1	-1.7	-1.2	-0.1	-1.3	1.8	1.7	0.5
Alcohol intake frequency.	1.2	2.8	6.9	1.4	0.9	-0.3	2.6	1.9	1.9	1.8	-1.7	-2.0	0.6
Comparative height size at age 10	0.4	1.9	8.8	0.5	0.2	0.7	-0.3	-1.0	1.0	0.2	-3.0	-0.7	2.7
Number of full sisters	0.3	0.4	2.1	0.4	1.5	-0.7	0.0	0.6	-0.7	0.1	0.2	0.0	-0.2
Suffer from ‘nerves’	1.1	1.7	4.5	0.9	0.4	1.6	2.1	0.2	1.4	1.2	-1.3	-0.4	1.9
Overall health rating	1.2	2.6	6.5	2.0	1.2	1.8	-0.2	2.2	1.2	2.5	-0.8	-1.9	-0.1
Chest pain or discomfort	1.2	1.8	3.3	1.4	1.8	-0.0	1.8	1.3	1.6	1.5	-1.0	-1.3	-0.0
Had major operations	0.8	0.9	1.8	0.4	-0.7	0.9	0.6	1.1	1.3	1.3	-0.7	-1.2	0.5
Age at last live birth	1.0	1.4	3.5	-1.1	0.9	-0.4	-1.9	-1.0	-1.5	-1.1	1.5	1.3	-0.2
Family relationship satisfaction	0.3	0.4	1.5	0.1	0.2	0.6	-0.1	-0.3	0.1	1.1	-1.2	-0.4	0.6
Leg pain on walking	0.6	0.7	3.0	0.3	-0.1	-0.3	-0.9	-1.2	0.4	-1.1	-0.5	0.2	1.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	3.0	-0.7	0.6	-0.1	1.7	0.8	-1.1	0.5	0.3	-0.7	-0.8
Commuting to job workplace: Car/motor vehicle	2.8	3.2	7.7	2.0	-0.4	1.8	1.6	2.1	1.5	2.8	-1.1	-2.3	-0.4
Illness, injury, bereavement, stress in last 2 years	3.4	4.1	10.9	-2.0	0.4	-0.8	-0.1	-2.9	-2.0	-3.3	1.4	2.9	1.8
Medication: Aspirin	1.4	1.8	4.5	1.9	1.5	1.0	0.3	2.1	0.4	1.2	-0.7	-1.4	1.6
Supplements: Vitamin C	0.6	0.7	1.7	0.9	1.3	0.3	1.1	0.7	0.5	1.0	-0.4	-0.2	-1.0
Knee pain experienced in last month	0.5	0.8	1.8	0.3	0.2	1.0	-0.9	0.2	0.2	1.3	-1.3	-0.8	1.3
Hypertension (Self-reported)	0.5	1.5	7.5	0.2	1.9	2.7	0.1	0.5	0.6	1.0	1.0	-0.7	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	3.5	1.2	0.3	-0.1	-0.0	-0.2	1.0	0.6	-0.8	-1.9	-0.7
Illnesses of father: Heart disease	0.7	0.9	2.7	-0.8	1.3	-0.3	-0.2	1.4	0.5	0.8	1.6	0.5	-1.1
Illnesses of siblings: Diabetes	0.6	0.7	2.4	1.3	-0.1	-0.1	-0.8	1.3	0.4	0.1	-0.1	0.3	1.5
Smoking status: Previous	0.2	0.4	1.2	-0.7	-0.3	-1.1	-0.2	0.0	0.5	-0.1	-0.9	-0.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.8	-0.8	0.3	-0.9	-0.1	0.4	-1.6	-1.7	1.7	1.9	-0.3
Whole body fat-free mass	0.3	2.0	7.2	1.1	1.2	1.6	0.4	0.4	0.8	-0.2	-2.4	-0.5	2.7
Leg fat-free mass (right)	0.4	2.1	8.6	1.1	1.5	1.4	0.6	0.5	0.8	0.0	-2.9	-0.7	2.3
Arm fat percentage (left)	0.5	2.0	6.6	0.6	2.2	1.1	0.3	0.6	1.0	0.7	-2.6	-1.2	1.9
Average weekly red wine intake	0.4	0.6	2.4	-0.1	-0.3	-0.1	-0.1	0.7	1.3	-0.7	0.5	1.5	-0.4
Handedness (chirality/laterality): Left-handed	2.6	3.1	7.2	2.0	-0.3	0.5	2.2	1.9	0.7	2.7	-1.5	-2.7	-1.0
Mood swings	0.9	1.6	8.8	1.0	1.0	3.0	-1.2	-0.3	1.0	1.5	0.3	0.0	0.6
Loneliness, isolation	1.6	2.2	6.0	1.6	1.9	0.7	0.6	1.0	0.9	2.4	-2.1	-1.8	0.5
Long-standing illness, disability or infirmity	1.2	1.9	5.0	2.0	0.5	1.9	-0.1	2.2	0.8	1.4	-0.6	-1.7	0.4
Ever had bowel cancer screening	0.7	0.8	2.4	-1.5	-0.1	0.7	-0.8	-1.0	-1.0	-0.9	0.5	0.9	-0.7
Diabetes diagnosed by doctor	0.6	1.0	4.8	0.2	-0.0	0.9	0.2	1.6	2.2	0.8	-0.5	-0.8	0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	7.8	0.0	2.8	-1.3	0.1	-1.4	-0.0	-1.2	0.4	0.5	-0.5
Friendships satisfaction	1.5	1.9	5.5	-2.1	-0.6	-0.9	-1.1	-2.3	-0.5	-0.1	-1.6	0.8	1.7
Qualifications: nursing, teaching	1.1	1.7	5.2	-0.6	-0.1	-1.9	-0.5	-0.9	-2.0	-2.3	-0.9	0.8	1.2
Commuting to job workplace: Walk	0.9	1.0	4.3	-0.8	-0.4	0.4	-1.6	-0.3	0.7	0.4	0.6	0.9	2.1
Eye problems/disorders: Cataract	0.3	0.3	2.4	0.2	-0.5	-0.4	-1.6	-0.0	0.4	0.0	-0.1	-0.0	0.0
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	8.5	-2.6	-0.6	-1.3	-0.0	-2.9	-0.7	-2.7	-0.1	1.7	0.3
Medication for cholesterol	0.3	0.5	2.7	0.2	-1.6	-0.2	-0.2	-0.3	-0.5	0.6	-0.9	-0.5	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	5.1	-1.0	0.9	1.0	-1.6	-0.4	0.2	-1.1	2.3	0.8	-1.3
Back pain experienced in last month	1.6	2.4	7.4	1.4	0.7	0.5	0.7	2.3	0.4	2.6	-1.1	-2.7	-0.4
Mineral and other dietary supplements	2.0	2.7	6.1	-2.0	0.6	-0.6	-1.8	-2.2	0.5	-2.5	1.3	2.2	0.9
Breast cancer (self-reported)	0.5	0.7	2.1	-0.8	0.9	1.4	-0.6	-0.6	0.0	-0.0	1.3	0.7	0.3
Asthma (self-reported)	0.4	0.7	3.3	0.3	-0.3	-0.8	0.1	1.3	-0.6	-0.1	0.9	-0.6	-1.8
Osteoporosis (self-reported)	0.8	1.0	5.3	0.8	0.1	1.1	-0.2	1.3	0.3	2.3	-0.0	-0.8	-0.4
Osteoarthritis (self-reported)	0.3	0.4	1.3	0.2	0.4	0.3	-0.7	-0.7	0.1	-0.5	0.3	0.8	1.2
Medication: Aspirin	1.2	1.5	3.7	1.9	1.2	0.7	0.4	1.7	0.5	1.0	-1.1	-1.3	1.6
Medication: Gliclazide	1.2	1.4	4.7	1.5	1.1	-0.2	2.2	0.9	-0.2	0.8	-1.7	-1.0	0.3
Illnesses of father: None of the above (group 1)	1.1	1.4	4.2	2.1	-0.2	0.7	-0.4	0.7	-0.8	-0.1	-1.6	-1.8	1.4
Smoking status: Current	1.1	1.8	4.2	1.2	1.5	2.1	-0.8	1.1	1.6	1.8	0.2	-1.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.5	-0.4	1.0	1.3	-0.7	0.5	0.5	1.0	1.6	0.0	-1.4
Whole body water mass	0.3	1.9	7.1	1.1	1.2	1.6	0.3	0.4	0.7	-0.2	-2.4	-0.5	2.7
Leg predicted mass (right)	0.4	2.1	8.8	1.1	1.6	1.3	0.6	0.5	0.8	0.0	-3.0	-0.8	2.3
Arm fat mass (left)	0.7	2.9	7.7	1.2	2.2	1.9	0.5	1.2	1.5	0.8	-2.8	-1.5	2.3
Number of self-reported non-cancer illnesses	0.8	1.4	3.2	1.7	0.8	1.8	-0.2	0.8	1.2	1.4	-0.7	-1.3	0.5
Average weekly champagne plus white wine intake	0.4	0.5	2.4	-0.6	-0.4	0.9	-0.7	0.0	0.4	-0.1	-0.1	0.7	1.5
Miserableness	0.7	1.3	5.9	0.6	0.8	2.4	-1.5	-0.5	0.9	1.2	-0.7	0.6	0.7
Guilty feelings	1.0	1.4	3.5	-0.9	-0.7	0.6	-1.5	-1.6	-1.4	-0.3	-1.0	1.1	1.9
Wears glasses or contact lenses	1.9	2.2	6.8	-0.7	-1.6	-1.7	0.4	-2.0	-1.2	-2.6	0.6	1.8	0.1
Ever taken oral contraceptive pill	0.4	0.5	1.2	0.2	-0.8	0.7	-1.1	1.0	0.3	0.2	1.0	-0.4	0.0
Hearing aid user	0.5	0.6	1.9	-0.9	-0.1	0.0	-1.4	-0.6	1.3	0.0	0.2	0.3	0.9
Mother’s age at death	0.7	0.8	1.4	-1.0	-1.1	-1.1	0.5	-1.2	-1.0	-0.9	-0.6	0.8	0.7
Financial situation satisfaction	1.1	1.3	3.6	0.7	-0.6	1.7	-0.8	1.6	1.1	1.0	1.9	-0.1	-0.8
Tinnitus: Yes, now most or all of the time	2.1	2.5	5.4	1.4	0.8	1.8	0.7	1.6	1.2	2.2	2.3	-1.0	-1.8
Commuting to job workplace: Public transport	1.4	1.7	7.3	-0.9	-0.8	-1.9	0.3	-1.3	-0.8	-2.7	-0.4	0.9	1.2
Eye problems/disorders: Glaucoma	0.3	0.4	2.6	0.2	-0.1	0.9	-0.1	0.3	-0.2	-0.0	1.6	0.6	0.4
Medication: Blood pressure	0.3	0.6	2.0	-0.6	1.3	0.8	-0.7	0.1	1.4	0.1	0.9	0.3	0.3
Pain type(s) experienced in last month: Hip pain	1.6	2.1	4.9	2.2	1.7	-0.3	0.2	2.0	1.1	1.2	-1.4	-1.8	1.0
Supplements: Fish oil (including cod liver oil)	1.4	1.8	5.0	1.6	0.1	0.5	2.2	0.9	-0.2	1.7	-2.2	-1.3	0.3
High cholesterol (Self-reported)	0.5	0.8	3.1	-0.4	1.8	0.5	1.4	-0.0	-0.9	0.2	-0.0	0.8	0.9
Medication: Bendroflumethiazide	0.6	0.9	3.9	-0.0	1.0	1.6	0.3	0.7	-0.1	0.5	2.0	0.5	-0.5
Medication: Paracetamol	0.3	0.4	1.4	0.1	-1.0	0.1	-0.1	0.2	-1.1	-0.1	-1.2	-0.1	-0.4
Medication: Lisinopril	0.3	0.4	2.5	-0.4	0.5	0.5	-1.6	-0.1	0.6	-0.1	0.6	0.4	-0.6
Medication: Atorvastatin	0.3	0.4	1.6	0.0	-0.6	1.3	0.4	0.2	-0.3	0.5	0.7	0.6	0.4
Illnesses of father: High blood pressure	2.3	2.9	8.1	-1.9	0.8	0.3	-0.6	-1.9	-0.6	-1.9	2.9	2.8	-0.6
Alcohol drinker status: Never	0.6	0.8	2.3	0.8	0.0	1.0	0.9	1.4	1.5	1.0	0.3	-0.2	-0.3
Ever smoked	0.4	0.6	1.4	0.0	0.4	-0.3	-0.9	0.8	0.9	0.7	-0.7	-1.2	1.1
Basal metabolic rate	0.4	2.3	7.8	1.2	1.4	1.7	0.4	0.5	0.9	0.0	-2.7	-0.7	2.8
Leg fat percentage (left)	0.5	2.0	3.9	1.1	1.8	1.9	0.0	0.9	1.4	1.0	-1.6	-1.1	2.0
Arm fat-free mass (left)	0.5	2.4	7.2	1.5	1.3	1.9	0.4	0.6	1.3	0.0	-2.5	-0.8	2.7
Number of operations (self-reported)	0.4	0.5	1.0	0.7	-1.0	1.0	0.9	0.5	1.0	0.5	-0.1	-0.2	0.8
Average weekly beer plus cider intake	0.3	0.5	2.0	-0.1	1.4	1.1	0.3	-1.1	-0.5	0.2	0.1	-0.2	-0.6
Irritability	0.7	1.3	4.3	1.6	-0.7	2.1	-0.8	0.7	0.6	1.2	-0.8	-0.4	1.2
Risk taking	0.2	0.2	1.1	-0.4	-0.1	-0.3	-1.1	0.4	0.3	-0.3	-0.6	0.4	-0.2
Ever had prostate specific antigen (PSA) test	0.9	1.0	4.9	0.9	0.2	2.2	-1.4	0.1	1.1	0.8	0.5	-0.0	0.5
Fractured/broken bones in last 5 years	0.7	0.8	2.7	0.4	1.2	0.9	0.8	0.1	0.2	0.8	-1.6	-1.4	-0.3
Age started oral contraceptive pill	0.3	0.4	1.3	0.6	-0.1	0.3	0.9	0.6	-0.7	-0.5	-0.6	0.0	1.1
Diastolic blood pressure, automated reading	0.1	0.4	1.7	-0.1	0.6	1.1	-0.2	0.1	0.6	-0.1	1.3	0.1	-0.5
Ever depressed for a whole week	0.7	0.8	3.9	-0.9	0.5	-0.0	-2.0	-0.8	1.1	0.1	-0.4	0.5	1.0
Unable to work because of sickness or disability	0.6	0.7	2.1	1.5	0.7	0.7	-0.9	-0.1	1.0	0.6	-0.3	-1.1	0.9
Commuting to job workplace: Cycle	0.4	0.5	1.4	0.0	-0.2	-0.1	1.1	-0.2	-0.8	1.2	-0.8	-0.6	-0.9
Myopia	1.4	2.0	5.2	-1.0	0.0	-0.9	1.2	0.4	-2.3	-1.8	1.7	2.3	0.1
Vascular/heart problems diagnosed by doctor	0.7	2.0	11.7	-0.9	-2.1	-3.4	0.0	-0.2	-0.7	-0.8	-1.1	0.2	0.6
Cholesterol lowering medication	0.4	0.6	1.4	0.2	0.9	1.1	0.0	0.8	0.5	0.6	1.2	0.8	0.9
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.4	0.8	0.7	0.1	1.4	1.1	0.3	1.5	-0.7	-0.9	-1.4
Pain experienced in last month	0.6	1.0	3.6	-0.7	0.4	-1.2	1.9	-1.4	-0.4	-1.3	0.1	0.8	0.1
Supplements: Calcium	0.4	0.4	1.6	-0.0	-1.1	-0.1	0.6	0.3	-0.4	0.9	0.4	0.0	-1.3
Basal cell carcinoma (self-reported)	0.3	0.4	1.2	-0.2	-0.4	-0.6	-1.1	-1.1	-0.3	-0.2	0.5	0.2	0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	3.2	-0.1	-0.1	-0.4	0.8	-0.2	0.5	0.5	-1.8	-0.9	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.5	-0.7	1.6	0.4	0.4	1.2	-0.1	0.6	1.0	0.4	-1.3
Heart disease (siblings)	3.8	4.6	11.5	2.1	-0.6	3.0	0.9	3.3	2.0	3.4	0.8	-1.6	-1.5
Alcohol drinker status: Previous	0.5	0.6	2.6	-1.0	-0.2	0.5	1.6	-0.6	-0.0	-0.6	-0.1	-0.0	1.3
Pack years of smoking	0.5	0.8	2.8	1.3	1.7	0.5	-1.1	-0.2	0.8	0.7	-0.1	-0.4	0.7
Impedance of whole body	0.5	2.7	7.1	-2.0	-2.0	-2.7	-0.9	-2.6	-1.0	-1.1	0.9	1.3	-0.0
Leg fat mass (left)	0.8	3.1	6.7	1.4	2.1	1.9	0.3	1.3	1.6	1.0	-2.6	-1.5	2.6
Arm predicted mass (left)	0.5	2.5	7.6	1.5	1.2	2.0	0.3	0.5	1.4	0.1	-2.6	-0.7	2.8