Hub : Genes

GHRL

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.2850 0.0950 1.7e-03 0.093 NA 0.112 NA 0.097 1.1e-03 NA 3.5e-04 NA 8.6e-04
2 GTEx Brain Cortex 0.4500 0.1210 1.6e-03 0.099 NA 0.016 NA 0.110 1.1e-03 NA 1.1e-01 NA 6.0e-04
3 GTEx Esophagus Muscularis 0.1390 0.0480 6.8e-04 0.076 NA 0.078 NA 0.080 2.3e-05 NA 1.8e-05 NA 1.4e-05
4 GTEx Liver 0.5390 0.1220 6.1e-04 -0.006 NA -0.002 NA -0.002 5.0e-01 NA 3.8e-01 NA 3.7e-01
5 GTEx Nerve Tibial 0.1118 0.0348 1.5e-04 0.089 NA 0.113 NA 0.118 7.5e-07 NA 2.3e-08 NA 1.1e-08
6 GTEx Prostate 0.3050 0.1250 4.1e-03 -0.003 NA 0.020 NA -0.001 3.9e-01 NA 1.0e-01 NA 3.5e-01
7 GTEx Thyroid 0.1740 0.0540 1.0e-04 0.023 NA 0.041 NA 0.050 6.2e-03 NA 4.0e-04 NA 1.0e-04
8 NTR Blood 0.0433 0.0132 6.4e-05 0.008 0.020 0.024 0.024 0.019 1.2e-03 2.5e-07 2.9e-08 2.0e-08 5.1e-07
9 YFS Blood 0.0919 0.0190 0.0e+00 0.094 0.059 0.093 0.089 0.093 4.1e-29 8.9e-19 1.1e-28 1.1e-27 7.6e-29
10 TCGA Kidney Renal Clear Cell Carcinoma 0.0515 0.0256 1.8e-03 0.018 0.025 0.018 NA 0.011 3.6e-03 7.6e-04 3.6e-03 NA 1.7e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.6 1.0 2.8 0.6 1.2 -1.1 -0.5 1.7 0.1 1.0 -0.4 -1.6 0.2
Bipolar Disorder or Schizophrenia 0.8 2.0 4.4 1.6 1.5 -0.8 0.5 1.7 0.9 2.1 -0.0 -2.1 -1.2
Depressed Affect (Nagel 2018) 2.0 4.3 12.3 1.3 3.2 3.5 -0.8 -0.1 2.1 2.9 -1.6 -1.1 1.2
Depression (Nagel 2018) 1.2 1.7 5.9 1.5 2.4 1.6 -0.5 0.3 1.1 1.4 -1.3 -0.9 0.6
Intelligence (Savage-Jansen 2018) 0.8 2.4 6.5 -1.3 -1.3 -1.9 -1.2 -0.6 -2.5 -2.5 1.3 1.1 0.3
Neuroticism (Nagel 2018) 1.0 2.4 7.9 1.1 1.9 2.8 -0.8 -0.7 0.7 2.1 -1.5 -0.5 1.5
Schizophrenia (2018) 0.7 1.5 3.4 1.5 1.0 -0.1 1.1 0.9 1.1 1.8 0.3 -1.4 -1.7
Schizophrenia vs Biploar Disorder 0.4 0.5 1.3 -0.1 -0.6 0.4 1.0 -0.9 -0.0 -0.1 1.0 1.1 -0.6
Worry (Nagel 2018) 0.3 0.7 1.7 0.5 0.5 1.3 0.6 -0.7 0.5 0.9 -1.2 0.3 1.2
Alzheimer’s Disease (in mother) 0.4 0.5 1.6 -0.1 0.5 -0.5 -0.6 -1.0 0.5 -0.0 -1.0 0.2 1.3
Alzheimer’s Disease (in father) 0.6 0.7 4.4 -0.5 -0.6 0.5 -0.1 -0.2 -0.5 0.3 0.8 0.8 -2.1
Alzheimer’s Disease (including proxy) 0.3 0.4 1.4 -0.2 0.6 0.3 -0.7 -1.1 0.3 -0.1 0.2 1.2 -0.5
Crohns Disease (2017) 0.5 1.1 5.8 0.9 -0.1 -1.2 -0.5 0.9 0.3 0.5 -1.2 0.1 2.4
Irritable Bowel Disease (IBD) 0.4 1.0 2.3 -0.7 -1.5 -1.4 -1.2 -0.4 -0.2 -0.7 -0.5 0.4 1.5
Ulcerative Colitis (UC) 0.7 1.3 4.8 -1.6 -2.2 -1.2 -1.2 -1.1 -0.7 -1.2 0.1 0.1 0.0
Major Depression (MDD) 0.3 0.4 1.8 -0.1 -0.7 0.1 0.2 0.7 1.3 0.8 0.4 -0.7 0.4
Reaction Time 0.2 0.5 2.0 0.6 0.6 -0.7 0.3 0.1 1.0 -0.3 -0.5 -0.2 1.4
Verbal and Numeric Reasoning (VNR) 0.9 2.2 6.0 -1.5 -1.4 -1.5 -1.1 -1.2 -2.5 -2.3 0.6 1.1 0.8
Breast Cancer 0.5 1.2 3.1 -0.4 -0.7 0.0 0.4 0.1 -1.3 -1.3 1.6 1.8 -1.3
Ovarian Cancer 3.6 4.8 9.4 -2.4 -2.8 -3.1 -0.5 -2.7 -0.8 -2.7 -0.1 1.9 2.4
Prostate Cancer 0.7 1.0 3.1 0.2 0.3 -1.4 0.6 0.5 -0.7 -1.1 1.2 0.9 -1.8
Age at First Birth 1.2 1.7 4.7 -1.3 0.1 -0.2 -0.6 -0.8 -1.4 -1.9 2.2 1.7 -1.1
Bipolar Disorder (2011) 2.3 2.2 10.0 2.1 -0.4 -0.5 1.1 1.2 0.7 1.3 -1.6 -3.2 -0.1
Body Mass Index (BMI) (2010) 0.5 0.7 2.9 0.4 -0.0 -0.1 0.4 -0.0 0.6 0.1 -1.7 -0.8 1.6
Coronary Artery Disease (CAD) 0.5 0.6 1.9 0.4 -0.9 -1.2 -0.3 1.4 0.5 0.3 0.9 -0.6 -0.2
Crohns Disease (2012) 0.4 0.6 2.7 0.0 0.5 -0.2 -1.6 0.5 -1.0 0.2 0.4 0.7 0.9
Mean Putamen Volume 0.3 0.4 1.7 -0.2 1.3 0.1 -0.4 -0.5 0.0 -0.5 0.4 1.0 -0.4
Fasting Glucose 0.3 0.3 0.9 -0.3 0.2 -0.2 -0.3 -0.0 -0.9 -0.6 1.0 0.9 -0.6
HbA1C 0.8 0.9 3.8 0.5 1.2 1.9 0.9 0.6 0.3 1.1 0.7 0.5 -0.8
HDL Cholesterol 1.2 1.9 3.8 -1.8 -1.6 -2.0 0.2 -1.6 -0.4 -1.7 1.1 1.1 -1.1
LDL Cholesterol 0.5 0.8 2.8 -1.0 0.3 0.9 -0.1 -1.7 0.7 -0.6 0.5 1.2 0.7
Lupus 0.5 0.8 4.3 -0.3 -0.3 -0.6 0.9 0.3 0.9 0.5 0.7 -0.9 -2.1
Neuroticism (2016) 1.4 2.0 6.9 1.5 2.1 2.6 -1.1 0.1 0.5 2.2 0.5 -0.3 0.2
Primary Biliary Cirrhosis 1.5 2.1 6.8 -1.5 1.5 0.1 -0.1 1.2 -0.4 -0.2 2.6 1.2 -2.6
Rheumatoid Arthritis 0.3 0.4 2.2 -0.1 -0.2 -0.2 1.5 0.0 0.8 -0.4 -0.5 -0.5 -0.5
Schizophrenia (2014) 0.2 0.5 1.9 0.5 0.2 -1.0 0.7 -0.3 -0.2 0.5 0.7 -0.6 -1.4
Triglycerides 0.3 0.4 1.5 -0.2 0.7 1.2 0.2 0.8 0.8 0.8 0.3 -0.7 0.2
Type 2 Diabetes (T2D) (2012) 2.0 2.3 5.8 -1.7 -0.7 -0.3 -0.3 -2.2 -0.2 -2.4 -0.3 2.0 2.0
Ulcerative Colitis 0.9 1.3 2.2 -1.3 -1.5 -1.4 -1.5 -1.0 -1.3 -1.2 0.7 0.1 -0.2
Blood Eosinophil Count 0.6 4.6 18.7 1.0 -4.3 -2.1 -0.3 -1.7 -0.0 0.8 -3.1 -2.9 -0.9
Blood Platelet Count 0.1 1.5 4.0 -1.4 -0.9 -1.0 -1.0 -1.6 -0.4 -2.0 1.6 0.9 0.7
Blood Red Count 0.1 1.0 2.1 1.0 0.6 0.3 0.7 0.5 1.4 0.3 -1.4 -1.1 1.5
Blood White Count 0.1 0.6 2.0 -0.6 0.4 0.9 -0.3 -0.3 -0.3 -0.9 1.4 0.3 -1.2
Heel T-Score 0.1 1.1 2.3 1.0 1.2 -0.1 0.2 1.4 1.5 1.5 -0.3 -1.0 0.8
BMI 0.4 2.6 5.4 1.4 2.3 2.0 1.1 1.8 1.4 0.1 -1.8 -1.0 2.0
Height 0.4 7.0 30.0 -0.1 -1.9 -1.6 0.2 -2.5 0.3 -1.4 -5.0 -0.2 5.5
Waist Hip Ratio (WHR) 0.3 1.5 2.7 -1.5 -1.2 -0.4 -1.6 -1.4 -0.4 -1.6 0.9 0.8 1.5
Systolic Blood Pressure 0.7 3.6 9.2 0.8 2.2 3.0 1.8 1.8 -0.5 1.5 1.8 -0.6 -2.9
Smoking Status 1.0 2.3 4.5 1.4 0.6 1.2 0.0 1.8 2.1 2.1 -1.5 -2.0 0.7
Allergy or Eczema 0.2 0.7 1.9 0.6 1.2 -0.8 0.2 1.4 0.6 0.5 0.3 -1.2 -0.3
Cardiovascular Disease 1.1 3.6 16.9 0.6 4.1 3.2 0.8 0.6 -1.1 -0.4 2.1 1.2 0.0
Hypothyroidism (self reported) 0.8 1.7 6.7 -1.1 -2.6 -2.4 -0.4 -0.9 -0.9 -1.2 -0.3 0.2 0.6
Respiratory disease 0.5 1.0 4.3 0.0 0.1 -0.8 -0.1 1.3 -0.4 -0.5 2.1 0.3 -1.8
Type 2 Diabetes (T2D) (2018) 1.0 1.8 6.8 1.1 0.4 1.8 0.7 1.5 2.6 1.3 -0.7 -1.1 -0.5
Lung FEV1/FVC ratio 0.1 0.4 1.4 -1.2 0.0 -0.6 -0.2 -0.2 -1.1 -0.4 0.2 0.5 -0.4
Lung FVC 0.2 0.8 4.1 0.6 0.5 1.1 -0.7 0.7 0.5 0.4 2.0 0.4 -0.8
Neuroticism 0.7 1.6 4.8 0.2 1.6 2.2 -0.7 -1.1 0.8 1.2 -1.2 0.4 1.9
Chronotype (morning person) 0.0 0.1 0.4 0.1 -0.1 -0.0 -0.7 -0.1 0.4 -0.1 0.5 -0.3 -0.2
Hair Pigment 0.1 2.1 5.8 0.7 1.1 1.2 1.9 2.4 1.4 1.1 -0.8 -0.9 -1.8
Tanning 0.2 2.4 7.1 1.3 -0.8 0.2 1.0 0.8 1.8 1.7 -2.2 -2.7 1.2
Hand grip strength (left) 0.3 0.9 4.1 0.3 0.7 0.2 0.2 1.1 -1.2 -0.2 2.0 0.9 -1.0
Number of treatments/medications taken 1.0 1.9 5.5 1.4 -0.1 2.3 0.5 1.5 0.1 1.9 -1.2 -1.8 0.8
Average weekly spirits intake 0.4 0.5 1.7 1.3 0.2 0.3 0.7 0.6 0.2 1.3 -0.3 -0.8 0.4
Sensitivity / hurt feelings 0.8 1.4 4.8 1.1 -0.7 2.2 0.2 -0.9 0.9 1.4 -1.4 -0.5 1.3
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.9 -0.1 1.4 0.9 -1.1 -0.7 -0.3 0.3 -0.8 0.4 0.7
Hearing difficulty/problems: Yes 1.0 1.5 5.5 0.0 0.2 1.9 -1.2 -1.1 -0.2 -0.9 0.6 1.5 2.3
Relative age of first facial hair 0.6 1.3 3.5 -1.5 -0.4 -0.7 -1.6 0.2 0.3 -0.5 1.9 1.0 -1.6
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 2.0 -0.0 0.2 0.9 -1.4 -0.9 0.3 0.4 -0.5 -0.6 1.1
Ever used hormone-replacement therapy (HRT) 0.6 0.8 2.3 -0.5 -0.0 -0.4 -0.1 0.1 0.1 1.2 -1.3 -1.3 1.5
Ever had hysterectomy (womb removed) 0.7 0.8 2.7 0.5 0.0 1.3 1.1 1.7 0.7 1.2 0.0 -0.2 0.2
Systolic blood pressure, automated reading 0.8 2.2 4.5 1.4 0.8 1.8 0.8 1.6 1.7 2.1 -0.1 -1.9 -1.4
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 4.2 1.4 -0.7 2.0 0.8 0.8 1.1 1.1 -1.0 -0.9 1.3
Angina 1.4 1.8 3.9 1.9 1.6 2.0 -0.4 1.2 0.9 1.0 -1.2 -0.6 1.6
Medication for hormone replacement therapy 0.2 0.3 1.6 0.0 0.5 -1.2 0.3 -0.0 -0.3 -0.2 0.1 -0.3 -0.7
Vitamin and mineral supplements 0.4 0.6 3.3 -0.8 1.8 0.3 -0.8 0.4 0.8 -0.4 0.4 0.5 0.4
Supplements: Zinc 0.5 0.5 1.8 -0.1 0.9 0.2 0.9 -0.5 -1.4 -0.3 0.4 1.1 -0.2
Medication: Co-codamol 1.2 1.4 6.3 1.4 -2.5 0.3 1.4 0.7 0.1 0.6 -1.2 -1.1 -0.2
Medication: Metformin 0.5 0.7 2.5 0.2 -0.1 0.5 0.7 1.0 1.6 0.9 -0.4 -1.1 -0.2
Diabetes (father) 0.4 0.4 1.6 -1.1 1.3 -0.7 -0.3 -0.1 0.0 -0.3 -0.1 0.8 -0.6
Diabetes (mother) 0.8 1.1 5.0 0.7 0.6 -0.0 -0.7 1.9 0.2 -0.1 2.2 0.9 0.1
Severe depression (siblings) 0.5 0.5 1.9 0.9 -0.3 1.4 0.9 0.5 0.8 0.7 -0.3 -0.4 0.4
Pack years adult smoking proportion 0.6 0.8 3.3 1.3 1.8 0.6 -1.4 -0.3 0.8 0.5 0.2 -0.4 0.3
Impedance of leg (right) 0.3 1.6 4.1 -1.0 -1.9 -2.0 -1.0 -1.3 -0.9 -0.6 1.6 0.8 0.2
Leg fat-free mass (left) 0.4 2.4 9.3 1.2 1.6 1.3 0.6 0.7 0.7 0.0 -3.1 -1.0 2.5
Trunk fat percentage 0.7 2.8 12.1 0.7 1.5 0.6 0.3 0.4 1.2 0.7 -3.5 -1.4 2.9
Hand grip strength (right) 0.3 0.9 4.6 -0.2 0.7 0.2 -0.7 0.9 -0.8 -0.4 2.1 0.8 -0.9
Townsend deprivation index at recruitment 0.8 1.1 4.6 -1.1 -0.2 -0.2 -0.0 -2.1 -1.4 -0.1 -1.1 1.0 -0.8
Current tobacco smoking 0.8 1.4 3.1 1.0 1.2 1.8 -0.6 1.0 1.5 1.5 -0.0 -1.5 -0.2
Average weekly fortified wine intake 0.7 0.8 1.5 0.5 -1.2 -0.9 1.0 -0.6 -0.8 -0.8 1.2 1.2 -0.2
Maternal smoking around birth 0.4 0.5 2.5 0.7 -0.0 1.6 0.5 -0.4 0.2 0.7 -0.6 0.1 1.0
Fed-up feelings 0.8 1.5 6.1 0.9 0.4 2.5 -1.0 -1.0 0.7 1.2 -1.0 -0.4 1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.9 0.9 1.7 1.1 0.1 -0.2 1.1 1.0 -1.5 -0.6 0.8
Relative age voice broke 0.6 0.9 2.2 -0.9 -0.1 -0.3 -1.1 1.1 1.2 0.3 1.3 0.7 -1.5
Taking other prescription medications 1.3 2.1 4.9 1.4 -0.5 2.1 -0.1 1.3 1.3 2.2 -1.1 -2.2 0.1
Age when periods started (menarche) 0.7 1.7 4.7 -1.6 -0.1 -1.9 -0.7 -1.5 -1.3 -2.2 0.4 1.2 -0.1
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 3.4 1.5 0.6 1.5 0.8 1.5 1.2 1.9 -0.2 -0.8 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.8 0.3 0.4 1.0 -0.1 1.3 1.2 0.3 0.9 0.4 0.4
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 3.3 0.7 -0.2 1.4 0.2 0.1 0.2 0.4 -0.9 -0.9 -1.8
Qualifications: CSEs or equivalent 1.0 1.4 4.3 1.2 0.8 2.1 0.3 1.3 0.6 1.6 1.0 -0.9 -1.0
Serious illness, injury or assault to yourself 3.3 4.0 11.1 2.3 -0.2 1.6 -0.0 2.4 1.3 2.9 -2.3 -3.3 -0.2
High blood pressure 0.7 1.8 9.9 0.5 2.2 3.1 0.1 0.3 0.4 0.8 1.3 -0.5 -0.7
Hayfever, allergic rhinitis or eczema 0.1 0.3 1.2 0.0 0.8 -1.1 -0.1 0.8 0.3 -0.4 0.5 -0.5 -0.1
Multivitamins +/- minerals 0.9 1.1 7.9 0.5 -2.8 -0.2 0.6 -0.9 -1.1 -0.4 -0.2 -0.0 0.4
Stomach or abdominal pain in last month 0.9 1.1 3.3 -1.2 -0.1 -1.4 1.2 0.2 0.4 -1.8 0.8 1.2 -0.7
Supplements: Glucosamine 0.3 0.4 2.0 -0.1 0.0 0.2 0.3 0.2 -1.4 0.5 -0.5 -0.0 1.3
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.8 -0.5 -0.8 -0.4 -0.0 -1.3 0.8 -0.8 -0.5 0.3 0.2
Medication: Atenolol 0.6 0.7 1.8 -0.5 0.7 1.2 -1.3 -0.2 1.1 1.2 0.1 -0.2 0.3
Medication: Levothyroxine sodium 0.3 0.5 2.6 0.1 -0.9 -0.3 0.0 -0.7 0.2 -0.4 -1.6 -0.7 -0.3
Sitting height 0.3 2.3 8.2 -0.9 -1.2 -0.6 -0.1 -1.8 -0.2 -1.0 -2.7 -0.1 2.9
Chronic bronchitis/emphysema (father) 0.6 0.7 1.7 0.4 -1.1 -0.8 0.4 0.3 0.8 0.7 -1.3 -0.9 1.2
High blood pressure (mother) 0.8 1.1 3.2 -0.5 1.8 -0.2 -0.5 0.2 -1.2 -0.8 1.6 1.6 -0.0
Body mass index (BMI) 0.8 3.3 6.0 1.7 2.4 2.4 0.5 1.7 1.6 1.1 -2.3 -1.5 2.0
Impedance of leg (left) 0.3 1.5 3.6 -1.1 -1.9 -1.9 -1.0 -1.5 -0.5 -0.5 1.6 0.8 -0.0
Leg predicted mass (left) 0.5 2.4 9.4 1.2 1.6 1.3 0.5 0.7 0.7 0.0 -3.1 -1.0 2.5
Trunk fat mass 0.8 3.3 13.0 0.9 1.7 0.9 0.3 0.5 1.3 0.5 -3.6 -1.4 3.4
Waist circumference 0.7 2.4 7.8 0.6 1.8 1.1 0.2 0.5 1.4 0.1 -2.8 -1.2 2.8
Number of incorrect matches in round 1.7 2.8 5.1 1.9 2.1 1.3 1.5 2.2 -0.3 1.9 -0.2 -2.2 -1.4
Past tobacco smoking 0.1 0.2 0.6 0.3 -0.4 0.4 0.8 -0.2 -0.8 -0.4 0.2 0.5 -0.6
Alcohol usually taken with meals 0.4 0.6 2.0 0.9 -0.6 0.8 0.1 0.9 0.4 -0.2 -0.9 -0.2 1.4
Nervous feelings 0.2 0.4 2.0 0.0 -0.0 1.4 0.0 -0.7 0.8 0.9 -0.0 0.3 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 4.7 2.0 1.2 2.2 -0.6 0.6 -0.1 1.6 -0.6 -0.1 0.2
Hearing difficulty/problems with background noise 2.1 3.4 10.9 -1.6 1.0 1.1 -2.2 -1.6 -0.5 -1.6 1.8 3.3 2.1
Hair/balding pattern: Pattern 2 0.8 1.0 3.0 0.7 0.7 -0.6 1.7 1.1 -0.2 0.6 0.2 -1.2 -1.7
Had menopause 0.8 1.0 2.4 0.5 -1.0 1.1 0.7 1.5 1.2 1.4 0.4 -0.5 1.0
Had other major operations 0.2 0.3 1.0 0.1 -0.2 -0.3 -1.0 1.0 0.8 0.2 0.3 -0.1 -0.3
Forced vital capacity (FVC) 0.1 0.4 1.1 0.6 -0.7 0.2 -1.0 0.2 -0.1 -0.6 1.1 0.8 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.6 2.0 1.0 0.4 1.4 0.0 1.0 1.0 0.6 -0.0 0.0 0.4
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.6 -0.1 1.3 0.8 -0.9 -0.2 0.6 0.8 -0.9 -1.0 1.1
Qualifications: None of the above 0.7 1.4 5.0 1.3 1.1 1.3 -0.0 0.5 1.4 2.2 -0.9 -1.1 0.4
Financial difficulties in last 2 years 1.0 1.3 5.3 0.1 0.1 1.2 -0.1 1.3 -0.9 1.6 1.3 -0.2 -2.3
Mouth/teeth dental problems 0.5 0.7 2.5 0.8 -0.0 -1.6 -0.1 1.1 -0.6 0.4 0.1 -1.4 -0.6
Heart attack 0.5 0.6 3.3 0.0 0.0 -0.5 0.6 0.2 0.2 0.8 -1.8 -1.2 -0.3
Allergy 0.2 0.6 2.3 -0.3 -0.4 0.4 -0.4 -1.5 -1.0 -0.2 -0.8 0.8 0.7
Pain all over the body in last month 1.0 1.1 5.0 0.2 -0.9 1.3 0.2 -0.8 1.3 -0.1 -0.9 0.3 2.2
Diabetes (self-reported) 0.9 1.4 4.3 0.8 -0.1 1.0 0.2 1.4 2.1 1.2 -1.4 -1.5 0.2
Hayfever/allergic rhinitis (self-reported) 1.4 1.8 3.9 -1.5 -0.4 -1.8 -2.0 -1.1 -1.0 -1.8 0.7 1.2 1.2
Medication: Ramipril 0.5 0.6 2.3 0.9 0.4 0.5 0.8 1.1 -0.2 0.2 -0.7 -1.5 0.0
Medication: Simvastatin 1.3 2.0 4.1 1.4 1.7 1.8 1.1 2.0 0.4 1.6 0.2 -1.0 -1.6
Fluid intelligence score 1.0 2.1 6.2 -1.4 -0.9 -2.5 -1.6 0.3 -1.9 -1.6 0.0 1.3 1.2
Illnesses of siblings 2.8 3.9 8.8 -2.9 -0.6 -3.0 0.6 -2.7 -2.4 -2.6 0.0 1.1 0.2
Neuroticism score 0.8 1.7 7.1 0.3 0.4 2.1 -0.5 -1.4 0.6 0.7 -1.2 0.6 2.7
Weight 0.7 3.3 11.3 1.4 1.8 1.7 0.3 0.6 1.1 0.3 -3.4 -1.1 3.2
Impedance of arm (right) 0.6 3.0 9.4 -2.4 -1.6 -3.1 -0.7 -2.7 -1.6 -0.9 0.1 1.0 -0.5
Arm fat percentage (right) 0.6 2.2 7.3 0.9 2.2 1.1 0.6 0.8 1.0 1.0 -2.7 -1.4 1.6
Trunk fat-free mass 0.3 1.5 6.3 1.0 0.8 1.8 0.1 0.2 0.6 -0.3 -1.8 -0.3 2.5
Hip circumference 0.7 3.1 13.2 1.0 1.7 1.1 0.5 0.9 0.7 0.2 -3.6 -1.0 3.1
Time employed in main current job 0.3 0.4 1.5 0.2 1.0 -0.3 0.0 1.2 -0.3 0.8 0.0 -0.6 -0.1
Alcohol intake versus 10 years previously 3.0 4.5 11.8 1.7 1.3 1.2 1.4 3.4 2.1 3.1 0.1 -2.6 -2.2
Father’s age at death 0.5 0.6 2.5 -0.2 0.4 -1.2 -0.4 0.3 -0.2 -0.1 -1.2 0.4 1.6
Worrier / anxious feelings 0.4 0.7 2.8 -0.4 -0.3 1.1 -0.3 -1.1 -0.1 -0.4 -0.3 1.2 1.7
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 4.4 1.3 2.1 0.4 -0.7 0.6 -0.4 0.8 -0.8 -1.6 0.2
Falls in the last year 1.0 1.4 3.6 -1.6 -0.8 0.6 -1.9 -1.3 -1.1 -0.3 1.1 1.3 0.9
Hair/balding pattern: Pattern 3 0.2 0.2 0.9 1.0 0.2 0.4 -0.1 0.1 0.3 0.0 -0.8 -0.3 0.7
Number of live births 0.4 0.6 1.8 -0.4 0.3 0.3 1.3 -0.6 1.2 -0.3 0.3 1.0 -0.7
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.7 0.4 -0.5 0.2 -0.4 0.5 -0.5 -0.3 0.8 0.5 0.2
Pulse rate 1.2 2.1 5.2 -1.0 -1.0 -0.8 -0.1 -1.1 -2.3 -2.1 1.6 2.1 -0.6
Happiness 0.4 0.4 1.1 -0.0 0.1 -0.3 -0.6 -0.0 0.4 0.9 -0.9 -0.9 1.1
Noisy workplace 1.1 1.3 5.3 1.1 0.4 0.9 0.8 1.1 1.1 1.6 -0.3 -2.3 0.3
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.2 0.2 -1.1 -0.8 0.1 0.5 -1.1 -0.6 0.7 0.6 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 6.6 -0.4 -0.5 -2.6 -0.1 0.9 -0.0 -0.6 -0.9 -1.1 0.7
Mouth/teeth dental problems: Dentures 1.3 2.1 4.9 1.6 1.1 2.2 0.1 1.4 2.2 2.1 -0.4 -1.1 0.3
Asthma 0.3 0.7 2.6 0.2 -0.1 -0.8 0.0 1.2 -1.0 -0.2 0.9 -0.4 -1.6
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 2.8 0.6 0.6 0.6 -0.7 1.7 -1.0 1.1 0.1 -0.3 -0.5
Medication: Cholesterol lowering 1.4 2.1 4.5 1.6 0.9 1.9 2.1 0.9 -0.0 1.8 -1.7 -1.8 -0.0
Depression (self-reported) 0.3 0.4 1.2 0.9 0.8 1.1 -0.2 -0.5 0.2 -0.0 -0.7 -0.6 0.6
Medication: Lansoprazole 0.8 1.0 2.0 0.7 1.1 1.0 -1.1 0.5 1.3 0.9 1.0 0.1 -1.4
Prospective memory result 1.0 1.3 3.7 1.9 -0.7 1.0 0.6 0.7 -0.5 1.3 -1.1 -1.6 1.1
Lung cancer (father) 0.5 0.6 4.1 -0.5 -2.0 0.6 -0.1 -0.7 0.4 0.1 -0.1 0.4 0.6
Illnesses of mother 0.7 0.9 2.3 -1.0 -0.4 -1.4 -0.5 -1.5 -0.7 -1.5 -0.1 0.6 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.9 0.8 0.3 0.3 -0.2 0.9 -0.5 0.5 0.6 -0.4 -0.4
Pulse wave Arterial Stiffness index 0.2 0.2 0.8 0.9 0.0 -0.3 -0.0 0.4 -0.2 0.1 0.8 -0.1 -0.0
Impedance of arm (left) 0.8 3.8 9.8 -2.9 -1.7 -3.1 -1.1 -3.0 -1.6 -1.5 0.3 1.4 -0.1
Arm fat mass (right) 0.7 3.0 9.7 1.2 1.9 1.6 0.6 1.0 1.5 1.0 -3.1 -1.7 2.3
Trunk predicted mass 0.3 1.5 6.2 1.0 0.8 1.9 0.1 0.2 0.7 -0.2 -1.8 -0.3 2.5
Standing height 0.3 2.5 10.4 -0.3 -1.2 -1.0 -0.5 -1.9 -0.6 -1.5 -2.4 0.7 3.2
Length of working week for main job 0.7 0.8 2.7 -0.6 0.6 -0.4 -1.6 -0.4 -0.9 -1.3 -0.4 0.6 0.7
Exposure to tobacco smoke at home 1.5 1.6 5.2 0.9 0.0 0.7 1.3 1.4 1.2 1.3 1.4 -1.0 -2.3
Breastfed as a baby 1.0 1.3 5.1 0.6 0.1 -0.2 1.2 1.2 -1.0 1.2 -0.9 -2.3 -1.0
Tense / ‘highly strung’ 0.7 1.1 4.5 2.1 0.5 0.9 0.3 0.4 1.2 1.4 -0.7 -1.2 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 2.2 -0.2 -0.5 0.3 -0.8 -0.7 -0.4 -0.4 0.7 1.1 1.5
Hair/balding pattern: Pattern 4 0.2 0.6 2.6 -0.7 0.8 1.6 0.1 0.1 -0.2 0.8 -0.4 1.0 -0.4
Birth weight of first child 0.7 1.4 4.9 0.1 -1.1 -0.2 0.3 -2.0 -0.3 -0.9 -2.2 0.6 1.4
Peak expiratory flow (PEF) 0.0 0.1 0.4 -0.6 -0.2 -0.3 0.5 0.1 -0.0 -0.2 -0.2 0.2 -0.5
Pulse wave reflection index 0.4 0.5 1.3 1.0 1.1 -0.0 0.5 1.0 0.2 0.3 0.8 -0.2 -0.2
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.2 1.0 1.0 1.5 -0.1 0.5 0.7 0.8 0.0 -1.0 -0.8
Loud music exposure frequency 0.7 0.8 1.7 -1.3 -0.1 0.8 -0.1 -0.5 1.2 0.6 1.2 0.1 -1.3
Qualifications: O levels/GCSEs or equivalent 0.5 0.9 4.0 -0.5 -0.8 -0.3 0.8 1.3 -0.3 0.1 1.1 -0.1 -2.0
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 4.1 -0.6 0.7 1.3 1.3 -0.8 -0.4 -0.9 0.9 2.0 -0.4
Blood clot in the leg (DVT) 0.5 0.7 2.5 -0.5 1.6 0.5 0.3 1.3 0.1 0.7 0.7 0.2 -1.1
Medication: Paracetamol 0.7 1.2 3.7 1.2 -1.0 0.6 0.2 1.0 -0.7 1.5 -1.9 -1.4 -0.1
Headache pain in last month 0.5 0.9 3.2 0.9 0.5 0.0 -1.2 1.8 -0.1 1.1 0.9 -0.9 -0.6
Medication for cholesterol, blood pressure or diabetes 1.2 2.1 4.2 -1.7 -0.9 -2.0 -1.5 -1.0 0.1 -1.8 1.1 2.0 0.7
Glaucoma (self-reported) 0.3 0.4 3.0 0.4 -0.2 -0.0 0.0 0.6 0.0 0.0 0.5 -0.4 1.7
Gout (self-reported) 0.7 0.9 3.4 -0.1 -1.0 -0.8 0.9 -0.7 -0.5 -0.0 -1.8 -1.2 -0.9
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.1 -0.7 -0.6 -0.8 -0.3 -0.9 0.1 -0.4 -1.0 -0.4 0.6
Medication: Amlodipine 0.4 0.5 2.1 0.4 0.8 1.3 -0.2 0.2 0.0 0.4 -0.2 -1.5 -0.6
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.9 0.6 -0.1 0.0 0.4 1.4 1.0 0.2 0.3 -0.1 -1.1
Birth weight 0.3 0.7 2.7 -1.0 -1.1 -1.6 -0.2 0.0 0.5 -0.7 -1.1 -0.6 0.4
Chronic bronchitis/emphysema (mother) 0.5 0.6 4.8 -0.0 -0.2 2.2 -0.5 -0.0 0.3 0.6 0.6 0.2 0.5
High blood pressure (siblings) 1.0 1.5 4.8 1.9 1.0 2.2 -0.5 0.6 1.6 1.0 -0.6 -0.6 0.2
Forced vital capacity (FVC), Best measure 0.1 0.2 1.0 1.0 -0.2 0.7 -0.4 0.5 -0.0 0.2 0.7 -0.1 0.0
Body fat percentage 0.6 2.5 8.5 1.0 1.7 1.1 0.3 0.6 1.3 0.9 -2.9 -1.4 2.6
Leg fat percentage (right) 0.6 2.0 4.1 1.3 1.7 1.9 -0.2 1.2 1.3 1.1 -1.5 -1.2 2.0
Arm fat-free mass (right) 0.4 2.0 7.9 1.0 1.1 1.8 0.4 0.7 1.4 -0.2 -2.1 -0.4 2.8
Exposure to tobacco smoke outside home 0.9 1.3 7.2 -0.6 0.5 -0.7 0.4 -0.0 0.9 0.9 -0.5 -1.5 -2.7
Comparative body size at age 10 0.4 1.0 4.1 -0.0 1.2 -0.7 1.0 -0.3 0.9 0.1 -2.0 -1.3 -0.3
Number of full brothers 0.6 0.7 1.6 1.2 0.7 0.8 0.1 0.5 1.2 0.9 -0.4 -0.7 1.3
Worry too long after embarrassment 0.6 1.0 3.2 -0.3 -0.4 0.6 -0.8 -1.8 -1.5 0.3 0.1 0.5 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.8 -0.0 0.6 1.3 0.0 -0.9 -0.3 0.1 0.6 0.4 0.9
Wheeze or whistling in the chest in last year 0.2 0.3 1.1 0.2 0.4 -0.4 -0.2 1.0 0.1 -0.2 1.1 -0.7 0.2
Number of children fathered 1.2 1.4 3.6 -0.3 0.3 1.3 0.6 1.2 1.6 1.5 1.1 -0.9 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.7 -0.3 -0.0 -0.3 0.5 -0.7 -0.8 -0.8 0.1 -0.1 1.3
Age at first live birth 2.3 4.0 9.5 -2.6 0.9 -2.0 -1.6 -1.2 -3.1 -2.5 2.0 2.0 -0.8
Pulse wave peak to peak time 0.3 0.3 1.2 -1.1 -0.1 -0.0 -0.0 -0.6 0.1 -0.3 -1.1 0.1 0.6
Health satisfaction 0.8 1.0 1.8 1.2 0.9 0.7 -0.6 1.1 -0.4 0.8 -1.3 -1.2 1.1
Shortness of breath walking on level ground 0.5 0.6 2.2 -0.7 0.4 -0.7 -0.7 -0.2 0.2 -0.8 0.9 1.0 1.5
Qualifications: College or University degree 1.2 3.9 6.1 -2.0 -1.6 -2.5 -1.4 -1.1 -2.1 -2.5 1.9 2.1 -2.1
Eye problems/disorders: None of the above 0.7 0.8 5.2 -0.3 0.4 -0.3 2.3 0.7 -0.9 -0.5 0.0 0.2 -0.6
Mouth/teeth dental problems: Loose teeth 2.0 2.4 6.7 -1.7 -1.1 -0.9 0.7 -2.5 -0.3 -1.6 -2.6 1.0 1.5
Emphysema/chronic bronchitis 0.7 0.8 2.3 -1.5 -0.3 -0.4 -0.9 -0.5 -0.9 -1.1 0.9 1.2 0.7
Medication for pain relief, constipation, heartburn 2.1 3.6 8.6 -2.5 -0.8 -1.4 0.1 -2.9 0.0 -2.6 2.0 2.8 0.0
Neck or shoulder pain in last month 0.6 0.8 4.4 0.6 -0.2 -0.1 -2.1 0.7 0.2 0.6 -1.3 -0.8 0.4
Medication: Blood pressure 1.4 2.5 6.2 1.8 0.9 2.5 1.1 1.0 -0.0 2.1 -1.3 -2.4 -0.9
Angina (self-reported) 1.1 1.5 3.2 1.7 1.6 1.8 -0.4 1.2 0.8 0.9 -0.9 -0.4 1.4
Migraine (self-reported) 1.1 1.4 3.2 1.8 -0.1 1.3 1.1 0.5 1.4 1.5 -1.6 -1.0 0.2
Medication: Ibuprofen 0.2 0.3 1.1 -0.1 -0.2 0.2 -1.0 0.7 -0.5 0.2 0.1 0.4 -0.7
Medication: Allopurinol 0.7 1.0 6.4 0.3 -0.4 -0.6 1.0 -0.8 0.1 -0.3 -2.5 -1.0 0.2
Medication: Omeprazole 0.2 0.2 0.5 0.3 0.1 -0.4 0.5 0.6 -0.3 0.7 -0.4 -0.7 -0.6
Medication: Seretide 50 evohaler 0.9 1.0 5.0 -0.0 -2.2 -0.3 -1.0 0.2 -0.2 -0.3 -0.0 0.3 2.0
Mean time to correctly identify matches 0.3 0.5 2.4 -0.2 -0.2 0.2 0.5 -0.2 1.6 -0.0 -0.6 -0.2 1.5
Heart disease (mother) 1.5 1.8 4.9 1.3 0.6 0.9 1.8 2.2 1.0 1.5 -1.0 -1.1 -1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.1 -0.9 -0.4 -0.5 -1.1 -0.2 -1.1 -0.4 0.9 0.5 -1.0
Whole body fat mass 0.8 3.2 11.4 1.3 1.7 1.3 0.6 0.7 1.4 0.7 -3.4 -1.6 2.9
Leg fat mass (right) 0.8 2.9 7.1 1.6 1.9 1.8 0.1 1.2 1.4 0.9 -2.4 -1.5 2.7
Arm predicted mass (right) 0.4 2.2 7.6 1.2 1.3 1.7 0.4 0.9 1.4 0.1 -2.2 -0.8 2.8
Pulse rate, automated reading 0.5 1.6 3.8 -1.9 -0.6 -0.1 -1.7 -1.2 -0.1 -1.3 1.8 1.7 0.5
Alcohol intake frequency. 1.2 2.8 6.9 1.4 0.9 -0.3 2.6 1.9 1.9 1.8 -1.7 -2.0 0.6
Comparative height size at age 10 0.4 1.9 8.8 0.5 0.2 0.7 -0.3 -1.0 1.0 0.2 -3.0 -0.7 2.7
Number of full sisters 0.3 0.4 2.1 0.4 1.5 -0.7 0.0 0.6 -0.7 0.1 0.2 0.0 -0.2
Suffer from ‘nerves’ 1.1 1.7 4.5 0.9 0.4 1.6 2.1 0.2 1.4 1.2 -1.3 -0.4 1.9
Overall health rating 1.2 2.6 6.5 2.0 1.2 1.8 -0.2 2.2 1.2 2.5 -0.8 -1.9 -0.1
Chest pain or discomfort 1.2 1.8 3.3 1.4 1.8 -0.0 1.8 1.3 1.6 1.5 -1.0 -1.3 -0.0
Had major operations 0.8 0.9 1.8 0.4 -0.7 0.9 0.6 1.1 1.3 1.3 -0.7 -1.2 0.5
Age at last live birth 1.0 1.4 3.5 -1.1 0.9 -0.4 -1.9 -1.0 -1.5 -1.1 1.5 1.3 -0.2
Family relationship satisfaction 0.3 0.4 1.5 0.1 0.2 0.6 -0.1 -0.3 0.1 1.1 -1.2 -0.4 0.6
Leg pain on walking 0.6 0.7 3.0 0.3 -0.1 -0.3 -0.9 -1.2 0.4 -1.1 -0.5 0.2 1.7
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 3.0 -0.7 0.6 -0.1 1.7 0.8 -1.1 0.5 0.3 -0.7 -0.8
Commuting to job workplace: Car/motor vehicle 2.8 3.2 7.7 2.0 -0.4 1.8 1.6 2.1 1.5 2.8 -1.1 -2.3 -0.4
Illness, injury, bereavement, stress in last 2 years 3.4 4.1 10.9 -2.0 0.4 -0.8 -0.1 -2.9 -2.0 -3.3 1.4 2.9 1.8
Medication: Aspirin 1.4 1.8 4.5 1.9 1.5 1.0 0.3 2.1 0.4 1.2 -0.7 -1.4 1.6
Supplements: Vitamin C 0.6 0.7 1.7 0.9 1.3 0.3 1.1 0.7 0.5 1.0 -0.4 -0.2 -1.0
Knee pain experienced in last month 0.5 0.8 1.8 0.3 0.2 1.0 -0.9 0.2 0.2 1.3 -1.3 -0.8 1.3
Hypertension (Self-reported) 0.5 1.5 7.5 0.2 1.9 2.7 0.1 0.5 0.6 1.0 1.0 -0.7 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 3.5 1.2 0.3 -0.1 -0.0 -0.2 1.0 0.6 -0.8 -1.9 -0.7
Illnesses of father: Heart disease 0.7 0.9 2.7 -0.8 1.3 -0.3 -0.2 1.4 0.5 0.8 1.6 0.5 -1.1
Illnesses of siblings: Diabetes 0.6 0.7 2.4 1.3 -0.1 -0.1 -0.8 1.3 0.4 0.1 -0.1 0.3 1.5
Smoking status: Previous 0.2 0.4 1.2 -0.7 -0.3 -1.1 -0.2 0.0 0.5 -0.1 -0.9 -0.3 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 3.8 -0.8 0.3 -0.9 -0.1 0.4 -1.6 -1.7 1.7 1.9 -0.3
Whole body fat-free mass 0.3 2.0 7.2 1.1 1.2 1.6 0.4 0.4 0.8 -0.2 -2.4 -0.5 2.7
Leg fat-free mass (right) 0.4 2.1 8.6 1.1 1.5 1.4 0.6 0.5 0.8 0.0 -2.9 -0.7 2.3
Arm fat percentage (left) 0.5 2.0 6.6 0.6 2.2 1.1 0.3 0.6 1.0 0.7 -2.6 -1.2 1.9
Average weekly red wine intake 0.4 0.6 2.4 -0.1 -0.3 -0.1 -0.1 0.7 1.3 -0.7 0.5 1.5 -0.4
Handedness (chirality/laterality): Left-handed 2.6 3.1 7.2 2.0 -0.3 0.5 2.2 1.9 0.7 2.7 -1.5 -2.7 -1.0
Mood swings 0.9 1.6 8.8 1.0 1.0 3.0 -1.2 -0.3 1.0 1.5 0.3 0.0 0.6
Loneliness, isolation 1.6 2.2 6.0 1.6 1.9 0.7 0.6 1.0 0.9 2.4 -2.1 -1.8 0.5
Long-standing illness, disability or infirmity 1.2 1.9 5.0 2.0 0.5 1.9 -0.1 2.2 0.8 1.4 -0.6 -1.7 0.4
Ever had bowel cancer screening 0.7 0.8 2.4 -1.5 -0.1 0.7 -0.8 -1.0 -1.0 -0.9 0.5 0.9 -0.7
Diabetes diagnosed by doctor 0.6 1.0 4.8 0.2 -0.0 0.9 0.2 1.6 2.2 0.8 -0.5 -0.8 0.0
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 7.8 0.0 2.8 -1.3 0.1 -1.4 -0.0 -1.2 0.4 0.5 -0.5
Friendships satisfaction 1.5 1.9 5.5 -2.1 -0.6 -0.9 -1.1 -2.3 -0.5 -0.1 -1.6 0.8 1.7
Qualifications: nursing, teaching 1.1 1.7 5.2 -0.6 -0.1 -1.9 -0.5 -0.9 -2.0 -2.3 -0.9 0.8 1.2
Commuting to job workplace: Walk 0.9 1.0 4.3 -0.8 -0.4 0.4 -1.6 -0.3 0.7 0.4 0.6 0.9 2.1
Eye problems/disorders: Cataract 0.3 0.3 2.4 0.2 -0.5 -0.4 -1.6 -0.0 0.4 0.0 -0.1 -0.0 0.0
Mouth/teeth dental problems: Mouth ulcers 1.8 2.8 8.5 -2.6 -0.6 -1.3 -0.0 -2.9 -0.7 -2.7 -0.1 1.7 0.3
Medication for cholesterol 0.3 0.5 2.7 0.2 -1.6 -0.2 -0.2 -0.3 -0.5 0.6 -0.9 -0.5 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 5.1 -1.0 0.9 1.0 -1.6 -0.4 0.2 -1.1 2.3 0.8 -1.3
Back pain experienced in last month 1.6 2.4 7.4 1.4 0.7 0.5 0.7 2.3 0.4 2.6 -1.1 -2.7 -0.4
Mineral and other dietary supplements 2.0 2.7 6.1 -2.0 0.6 -0.6 -1.8 -2.2 0.5 -2.5 1.3 2.2 0.9
Breast cancer (self-reported) 0.5 0.7 2.1 -0.8 0.9 1.4 -0.6 -0.6 0.0 -0.0 1.3 0.7 0.3
Asthma (self-reported) 0.4 0.7 3.3 0.3 -0.3 -0.8 0.1 1.3 -0.6 -0.1 0.9 -0.6 -1.8
Osteoporosis (self-reported) 0.8 1.0 5.3 0.8 0.1 1.1 -0.2 1.3 0.3 2.3 -0.0 -0.8 -0.4
Osteoarthritis (self-reported) 0.3 0.4 1.3 0.2 0.4 0.3 -0.7 -0.7 0.1 -0.5 0.3 0.8 1.2
Medication: Aspirin 1.2 1.5 3.7 1.9 1.2 0.7 0.4 1.7 0.5 1.0 -1.1 -1.3 1.6
Medication: Gliclazide 1.2 1.4 4.7 1.5 1.1 -0.2 2.2 0.9 -0.2 0.8 -1.7 -1.0 0.3
Illnesses of father: None of the above (group 1) 1.1 1.4 4.2 2.1 -0.2 0.7 -0.4 0.7 -0.8 -0.1 -1.6 -1.8 1.4
Smoking status: Current 1.1 1.8 4.2 1.2 1.5 2.1 -0.8 1.1 1.6 1.8 0.2 -1.5 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.5 -0.4 1.0 1.3 -0.7 0.5 0.5 1.0 1.6 0.0 -1.4
Whole body water mass 0.3 1.9 7.1 1.1 1.2 1.6 0.3 0.4 0.7 -0.2 -2.4 -0.5 2.7
Leg predicted mass (right) 0.4 2.1 8.8 1.1 1.6 1.3 0.6 0.5 0.8 0.0 -3.0 -0.8 2.3
Arm fat mass (left) 0.7 2.9 7.7 1.2 2.2 1.9 0.5 1.2 1.5 0.8 -2.8 -1.5 2.3
Number of self-reported non-cancer illnesses 0.8 1.4 3.2 1.7 0.8 1.8 -0.2 0.8 1.2 1.4 -0.7 -1.3 0.5
Average weekly champagne plus white wine intake 0.4 0.5 2.4 -0.6 -0.4 0.9 -0.7 0.0 0.4 -0.1 -0.1 0.7 1.5
Miserableness 0.7 1.3 5.9 0.6 0.8 2.4 -1.5 -0.5 0.9 1.2 -0.7 0.6 0.7
Guilty feelings 1.0 1.4 3.5 -0.9 -0.7 0.6 -1.5 -1.6 -1.4 -0.3 -1.0 1.1 1.9
Wears glasses or contact lenses 1.9 2.2 6.8 -0.7 -1.6 -1.7 0.4 -2.0 -1.2 -2.6 0.6 1.8 0.1
Ever taken oral contraceptive pill 0.4 0.5 1.2 0.2 -0.8 0.7 -1.1 1.0 0.3 0.2 1.0 -0.4 0.0
Hearing aid user 0.5 0.6 1.9 -0.9 -0.1 0.0 -1.4 -0.6 1.3 0.0 0.2 0.3 0.9
Mother’s age at death 0.7 0.8 1.4 -1.0 -1.1 -1.1 0.5 -1.2 -1.0 -0.9 -0.6 0.8 0.7
Financial situation satisfaction 1.1 1.3 3.6 0.7 -0.6 1.7 -0.8 1.6 1.1 1.0 1.9 -0.1 -0.8
Tinnitus: Yes, now most or all of the time 2.1 2.5 5.4 1.4 0.8 1.8 0.7 1.6 1.2 2.2 2.3 -1.0 -1.8
Commuting to job workplace: Public transport 1.4 1.7 7.3 -0.9 -0.8 -1.9 0.3 -1.3 -0.8 -2.7 -0.4 0.9 1.2
Eye problems/disorders: Glaucoma 0.3 0.4 2.6 0.2 -0.1 0.9 -0.1 0.3 -0.2 -0.0 1.6 0.6 0.4
Medication: Blood pressure 0.3 0.6 2.0 -0.6 1.3 0.8 -0.7 0.1 1.4 0.1 0.9 0.3 0.3
Pain type(s) experienced in last month: Hip pain 1.6 2.1 4.9 2.2 1.7 -0.3 0.2 2.0 1.1 1.2 -1.4 -1.8 1.0
Supplements: Fish oil (including cod liver oil) 1.4 1.8 5.0 1.6 0.1 0.5 2.2 0.9 -0.2 1.7 -2.2 -1.3 0.3
High cholesterol (Self-reported) 0.5 0.8 3.1 -0.4 1.8 0.5 1.4 -0.0 -0.9 0.2 -0.0 0.8 0.9
Medication: Bendroflumethiazide 0.6 0.9 3.9 -0.0 1.0 1.6 0.3 0.7 -0.1 0.5 2.0 0.5 -0.5
Medication: Paracetamol 0.3 0.4 1.4 0.1 -1.0 0.1 -0.1 0.2 -1.1 -0.1 -1.2 -0.1 -0.4
Medication: Lisinopril 0.3 0.4 2.5 -0.4 0.5 0.5 -1.6 -0.1 0.6 -0.1 0.6 0.4 -0.6
Medication: Atorvastatin 0.3 0.4 1.6 0.0 -0.6 1.3 0.4 0.2 -0.3 0.5 0.7 0.6 0.4
Illnesses of father: High blood pressure 2.3 2.9 8.1 -1.9 0.8 0.3 -0.6 -1.9 -0.6 -1.9 2.9 2.8 -0.6
Alcohol drinker status: Never 0.6 0.8 2.3 0.8 0.0 1.0 0.9 1.4 1.5 1.0 0.3 -0.2 -0.3
Ever smoked 0.4 0.6 1.4 0.0 0.4 -0.3 -0.9 0.8 0.9 0.7 -0.7 -1.2 1.1
Basal metabolic rate 0.4 2.3 7.8 1.2 1.4 1.7 0.4 0.5 0.9 0.0 -2.7 -0.7 2.8
Leg fat percentage (left) 0.5 2.0 3.9 1.1 1.8 1.9 0.0 0.9 1.4 1.0 -1.6 -1.1 2.0
Arm fat-free mass (left) 0.5 2.4 7.2 1.5 1.3 1.9 0.4 0.6 1.3 0.0 -2.5 -0.8 2.7
Number of operations (self-reported) 0.4 0.5 1.0 0.7 -1.0 1.0 0.9 0.5 1.0 0.5 -0.1 -0.2 0.8
Average weekly beer plus cider intake 0.3 0.5 2.0 -0.1 1.4 1.1 0.3 -1.1 -0.5 0.2 0.1 -0.2 -0.6
Irritability 0.7 1.3 4.3 1.6 -0.7 2.1 -0.8 0.7 0.6 1.2 -0.8 -0.4 1.2
Risk taking 0.2 0.2 1.1 -0.4 -0.1 -0.3 -1.1 0.4 0.3 -0.3 -0.6 0.4 -0.2
Ever had prostate specific antigen (PSA) test 0.9 1.0 4.9 0.9 0.2 2.2 -1.4 0.1 1.1 0.8 0.5 -0.0 0.5
Fractured/broken bones in last 5 years 0.7 0.8 2.7 0.4 1.2 0.9 0.8 0.1 0.2 0.8 -1.6 -1.4 -0.3
Age started oral contraceptive pill 0.3 0.4 1.3 0.6 -0.1 0.3 0.9 0.6 -0.7 -0.5 -0.6 0.0 1.1
Diastolic blood pressure, automated reading 0.1 0.4 1.7 -0.1 0.6 1.1 -0.2 0.1 0.6 -0.1 1.3 0.1 -0.5
Ever depressed for a whole week 0.7 0.8 3.9 -0.9 0.5 -0.0 -2.0 -0.8 1.1 0.1 -0.4 0.5 1.0
Unable to work because of sickness or disability 0.6 0.7 2.1 1.5 0.7 0.7 -0.9 -0.1 1.0 0.6 -0.3 -1.1 0.9
Commuting to job workplace: Cycle 0.4 0.5 1.4 0.0 -0.2 -0.1 1.1 -0.2 -0.8 1.2 -0.8 -0.6 -0.9
Myopia 1.4 2.0 5.2 -1.0 0.0 -0.9 1.2 0.4 -2.3 -1.8 1.7 2.3 0.1
Vascular/heart problems diagnosed by doctor 0.7 2.0 11.7 -0.9 -2.1 -3.4 0.0 -0.2 -0.7 -0.8 -1.1 0.2 0.6
Cholesterol lowering medication 0.4 0.6 1.4 0.2 0.9 1.1 0.0 0.8 0.5 0.6 1.2 0.8 0.9
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.4 0.8 0.7 0.1 1.4 1.1 0.3 1.5 -0.7 -0.9 -1.4
Pain experienced in last month 0.6 1.0 3.6 -0.7 0.4 -1.2 1.9 -1.4 -0.4 -1.3 0.1 0.8 0.1
Supplements: Calcium 0.4 0.4 1.6 -0.0 -1.1 -0.1 0.6 0.3 -0.4 0.9 0.4 0.0 -1.3
Basal cell carcinoma (self-reported) 0.3 0.4 1.2 -0.2 -0.4 -0.6 -1.1 -1.1 -0.3 -0.2 0.5 0.2 0.2
Heart attack/myocardial infarction (self-reported) 0.4 0.5 3.2 -0.1 -0.1 -0.4 0.8 -0.2 0.5 0.5 -1.8 -0.9 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.5 -0.7 1.6 0.4 0.4 1.2 -0.1 0.6 1.0 0.4 -1.3
Heart disease (siblings) 3.8 4.6 11.5 2.1 -0.6 3.0 0.9 3.3 2.0 3.4 0.8 -1.6 -1.5
Alcohol drinker status: Previous 0.5 0.6 2.6 -1.0 -0.2 0.5 1.6 -0.6 -0.0 -0.6 -0.1 -0.0 1.3
Pack years of smoking 0.5 0.8 2.8 1.3 1.7 0.5 -1.1 -0.2 0.8 0.7 -0.1 -0.4 0.7
Impedance of whole body 0.5 2.7 7.1 -2.0 -2.0 -2.7 -0.9 -2.6 -1.0 -1.1 0.9 1.3 -0.0
Leg fat mass (left) 0.8 3.1 6.7 1.4 2.1 1.9 0.3 1.3 1.6 1.0 -2.6 -1.5 2.6
Arm predicted mass (left) 0.5 2.5 7.6 1.5 1.2 2.0 0.3 0.5 1.4 0.1 -2.6 -0.7 2.8