TWAS hub - GMPR

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Small Intestine Terminal Ileum	0.5290	0.1420	0.0043	0.215	NA	0.036	NA	0.123	1.4e-05	NA	5.4e-02	NA	1.1e-03
2	YFS	Blood	0.0353	0.0136	0.0027	0.026	0.005	0.018	0.013	0.023	5.5e-09	0.0075	8.3e-07	2.4e-05	5.0e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Had major operations	5.0	5.9	8.3	1.9	-2.9
Blood Red Count	4.3	41.4	71.9	-3.3	8.5
Medication: Cholesterol lowering	3.8	6.0	7.3	2.7	-2.1
Handedness (chirality/laterality): Left-handed	3.7	4.5	6.8	-1.5	2.6
Type 2 Diabetes (T2D) (2012)	3.4	3.9	4.5	1.8	-2.1
Time employed in main current job	3.4	3.9	4.9	-2.2	1.7
Average weekly spirits intake	3.3	4.1	4.2	-2.0	2.0
Medication for cholesterol, blood pressure or diabetes	3.2	5.4	6.5	-2.6	2.1
Number of operations (self-reported)	3.2	4.7	6.3	1.7	-2.5
Ever had prostate specific antigen (PSA) test	3.2	3.7	6.7	2.6	-0.9
Diabetes (mother)	3.1	3.9	6.3	1.2	-2.5
Mouth/teeth dental problems: Bleeding gums	3.1	4.1	8.1	-0.1	2.8
Loneliness, isolation	2.8	3.8	7.3	-2.7	-0.5
Leg predicted mass (right)	2.8	14.9	21.2	2.9	-4.6
Impedance of leg (right)	2.7	13.2	16.5	-3.1	4.1
Leg fat-free mass (right)	2.7	14.4	20.3	2.9	-4.5
Leg predicted mass (left)	2.6	13.6	20.3	2.6	-4.5
Leg fat-free mass (left)	2.5	13.5	20.2	2.6	-4.5
Impedance of leg (left)	2.5	12.3	16.0	-2.9	4.0
Qualifications: O levels/GCSEs or equivalent	2.5	3.9	4.5	1.8	-2.1
Whole body water mass	2.5	14.4	21.3	2.7	-4.6
Pack years adult smoking proportion	2.4	3.6	4.1	2.0	-1.8
Arm fat-free mass (right)	2.4	12.2	18.2	2.5	-4.3
Whole body fat-free mass	2.4	13.6	20.4	2.6	-4.5
Arm predicted mass (left)	2.4	12.1	19.1	2.2	-4.4
Trunk fat-free mass	2.3	13.0	19.2	2.6	-4.4
Basal metabolic rate	2.3	12.6	19.9	2.3	-4.5
Impedance of whole body	2.3	11.8	16.5	-2.7	4.1
Trunk predicted mass	2.2	12.7	19.0	2.5	-4.4
Arm predicted mass (right)	2.2	11.5	17.4	2.4	-4.2
Average weekly champagne plus white wine intake	2.2	3.0	5.6	2.4	0.6
Arm fat-free mass (left)	2.2	10.9	18.1	1.9	-4.3
Systolic blood pressure, automated reading	2.1	6.1	6.1	-2.5	2.5
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	3.0	1.2	-1.7
Heart attack	2.1	2.7	4.8	0.8	-2.2
Loud music exposure frequency	2.1	2.3	2.7	1.4	-1.6
Neck or shoulder pain in last month	2.1	3.0	6.0	-2.5	0.2
Frequency of depressed mood in last 2 weeks	2.0	2.9	4.8	-2.2	-0.9
Hip circumference	2.0	8.8	16.6	1.0	-4.1
Impedance of arm (left)	2.0	9.3	13.5	-2.2	3.7
Friendships satisfaction	2.0	2.5	4.9	0.0	2.2
Medication: Blood pressure	2.0	3.8	4.5	-2.1	1.8
Pulse wave Arterial Stiffness index	1.9	2.2	2.8	-1.3	1.7
Pulse wave peak to peak time	1.9	2.2	2.7	1.3	-1.6
Smoking status: Previous	1.9	2.9	4.8	-1.0	2.2
Breast cancer (self-reported)	1.9	2.2	2.6	-1.6	-1.4
Miserableness	1.9	3.3	5.6	1.0	-2.4
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	3.2	1.0	-1.8
Hearing difficulty/problems with background noise	1.8	2.8	5.1	-0.8	2.2
Impedance of arm (right)	1.8	8.6	12.0	-2.3	3.5
High blood pressure (siblings)	1.8	2.6	4.6	0.8	-2.1
Medication for pain relief, constipation, heartburn	1.8	3.1	5.8	-0.6	2.4
Medication: Ibuprofen	1.8	2.2	3.6	0.8	-1.9
Medication: Paracetamol	1.8	2.8	4.6	1.0	-2.1
Crohns Disease (2017)	1.7	3.6	6.7	-2.6	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	3.3	-1.8	-1.2
Relative age voice broke	1.7	2.6	3.2	-1.4	1.8
Body mass index (BMI)	1.7	7.1	14.1	0.4	-3.8
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	4.0	0.5	-2.0
Commuting to job workplace: Car/motor vehicle	1.7	1.9	3.3	-0.7	1.8
Commuting to job workplace: Walk	1.7	1.8	1.9	1.4	1.3
Eye problems/disorders: Cataract	1.7	2.0	3.9	-2.0	-0.2
Basal cell carcinoma (self-reported)	1.7	2.0	3.5	-0.7	1.9
Pack years of smoking	1.7	2.5	3.7	1.9	-1.1
LDL Cholesterol	1.6	2.5	4.4	0.8	-2.1
Hearing difficulty/problems: Yes	1.6	2.5	4.0	-1.0	2.0
Average weekly fortified wine intake	1.6	1.8	3.6	-1.9	0.1
Age when periods started (menarche)	1.6	3.8	7.3	-0.5	2.7
Weight	1.6	7.9	14.1	1.3	-3.8
Peak expiratory flow (PEF)	1.6	3.7	6.0	1.2	-2.4
Family relationship satisfaction	1.6	1.9	2.7	-1.1	1.6
Severe depression (siblings)	1.5	1.7	1.8	1.2	-1.3
Angina (self-reported)	1.5	1.9	1.9	1.4	-1.4
Fasting Glucose	1.4	1.6	2.9	-1.7	0.7
Financial difficulties in last 2 years	1.4	1.8	3.6	-0.1	-1.9
Arm fat mass (right)	1.4	5.8	11.6	0.3	-3.4
Overall health rating	1.4	3.0	4.3	-2.1	-1.3
Ever had bowel cancer screening	1.4	1.6	3.1	-0.2	1.8
Arm fat mass (left)	1.4	5.8	11.6	0.3	-3.4
Ever had hysterectomy (womb removed)	1.3	1.4	2.7	0.5	-1.6
Had other major operations	1.3	1.6	2.1	1.0	-1.5
Qualifications: None of the above	1.3	2.7	5.1	-2.3	0.6
Pulse wave reflection index	1.3	1.6	2.3	-1.5	1.0
Irritability	1.3	2.2	3.4	-1.8	1.0
Heart attack/myocardial infarction (self-reported)	1.3	1.6	2.8	0.7	-1.7
Major Depression (MDD)	1.2	1.5	1.9	-1.4	-1.1
Prostate Cancer	1.2	1.7	2.2	1.1	-1.5
Angina	1.2	1.6	1.9	1.4	-1.2
Medication: Metformin	1.2	1.7	3.2	-1.8	-0.5
Glaucoma (self-reported)	1.2	1.5	2.4	1.6	-0.7
Medication for cholesterol	1.2	1.9	3.0	1.7	-0.8
Crohns Disease (2012)	1.1	1.7	2.8	-1.7	0.8
Systolic Blood Pressure	1.1	5.6	9.4	-1.4	3.1
Supplements: Zinc	1.1	1.2	2.3	0.4	-1.5
Medication: Co-codamol	1.1	1.3	2.2	-1.5	-0.6
Maternal smoking around birth	1.1	1.7	2.9	1.7	-0.6
Hayfever, allergic rhinitis or eczema	1.1	2.5	4.8	2.2	-0.4
Medication: Atenolol	1.1	1.3	1.5	-1.1	-1.2
Waist circumference	1.1	4.2	8.2	-0.4	-2.9
Father’s age at death	1.1	1.5	2.1	0.9	1.4
Medication: Paracetamol	1.1	1.8	3.5	0.4	-1.9
Mean time to correctly identify matches	1.1	2.0	3.6	-0.7	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	1.5	1.2	-1.1
Age at last live birth	1.1	1.6	2.8	-1.7	0.6
Illnesses of father: Heart disease	1.1	1.5	2.4	0.8	-1.5
Qualifications: nursing, teaching	1.1	1.7	3.4	1.9	-0.1
Commuting to job workplace: Public transport	1.1	1.3	2.0	1.4	-0.8
Unable to work because of sickness or disability	1.1	1.4	2.2	-1.5	-0.8
Schizophrenia vs Biploar Disorder	1.0	1.3	2.0	1.4	0.8
Ever used hormone-replacement therapy (HRT)	1.0	1.2	1.4	1.0	-1.2
Supplements: Glucosamine	1.0	1.3	2.4	0.5	-1.6
Exposure to tobacco smoke at home	1.0	1.1	1.2	1.0	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.4	-0.8	-1.5
Migraine (self-reported)	1.0	1.3	2.3	0.5	-1.5
Medication: Allopurinol	1.0	1.4	1.6	1.3	-1.1
Supplements: Vitamin C	1.0	1.2	1.9	-1.4	-0.6
Average weekly red wine intake	1.0	1.5	2.1	0.9	-1.5
Osteoarthritis (self-reported)	1.0	1.3	1.5	-1.0	1.2
Leg fat mass (left)	1.0	3.9	7.8	0.1	-2.8
Depression (Nagel 2018)	0.9	1.4	2.4	-1.6	-0.5
BMI	0.9	5.1	8.5	-1.3	-2.9
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	1.8	0.8	-1.3
Chronic bronchitis/emphysema (father)	0.9	1.0	1.4	-0.8	-1.2
Past tobacco smoking	0.9	1.7	2.8	0.8	-1.7
Falls in the last year	0.9	1.2	2.3	-1.5	-0.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	1.4	0.9	-1.2
Exposure to tobacco smoke outside home	0.9	1.2	1.7	-0.9	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.5	-0.8	1.2
Whole body fat mass	0.9	3.7	7.4	0.1	-2.7
Leg fat mass (right)	0.9	3.5	7.0	-0.0	-2.6
Ever taken oral contraceptive pill	0.9	1.0	1.1	-1.1	0.9
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.1	0.4	-1.5
Average weekly beer plus cider intake	0.9	1.3	2.3	-0.5	-1.5
Myopia	0.9	1.3	2.6	1.6	0.3
Cholesterol lowering medication	0.9	1.4	2.4	-1.5	-0.6
Type 2 Diabetes (T2D) (2018)	0.8	1.5	2.5	-1.6	-0.7
Number of treatments/medications taken	0.8	1.5	2.9	-0.4	-1.7
Taking other prescription medications	0.8	1.3	1.7	-0.9	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.0	-0.7	-1.4
Fluid intelligence score	0.8	1.7	2.4	1.6	-1.0
Illnesses of siblings	0.8	1.1	2.2	0.0	1.5
Arm fat percentage (right)	0.8	3.0	5.8	-0.5	-2.4
Illnesses of mother	0.8	1.0	1.5	-1.2	0.8
Breastfed as a baby	0.8	0.9	1.8	1.4	0.2
Medication: Blood pressure	0.8	1.4	2.2	1.5	-0.8
Arm fat percentage (left)	0.8	3.1	6.1	-0.3	-2.5
Eye problems/disorders: Glaucoma	0.8	0.9	1.2	1.1	-0.8
High cholesterol (Self-reported)	0.8	1.5	2.7	0.5	-1.6
Fractured/broken bones in last 5 years	0.8	1.0	1.9	-0.3	-1.4
Body Mass Index (BMI) (2010)	0.7	1.0	1.1	-1.0	-0.9
Triglycerides	0.7	1.1	1.7	-0.7	1.3
Number of incorrect matches in round	0.7	1.2	2.4	-0.1	1.5
Allergy	0.7	1.7	2.0	-1.4	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.3	-1.1	-0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.5	0.9	-1.6
Medication: Lansoprazole	0.7	0.8	1.1	-1.1	0.8
Length of working week for main job	0.7	0.8	0.9	0.8	-1.0
Number of children fathered	0.7	0.8	1.5	0.4	-1.2
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.1	-1.0	0.8
Suffer from ‘nerves’	0.7	1.1	2.2	-1.5	-0.2
Mineral and other dietary supplements	0.7	0.9	1.5	-0.6	1.2
Wears glasses or contact lenses	0.7	0.8	1.6	0.1	1.2
Bipolar Disorder (2018)	0.6	0.9	1.9	-1.4	-0.1
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.9	1.7	-0.4
Mean Putamen Volume	0.6	0.6	1.1	1.1	-0.4
Hand grip strength (left)	0.6	1.5	2.8	1.7	0.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	0.9	-0.9	-0.7
Current tobacco smoking	0.6	1.0	1.4	0.7	-1.2
Qualifications: CSEs or equivalent	0.6	0.8	1.4	-1.2	0.4
Sitting height	0.6	4.6	5.4	1.9	-2.3
Trunk fat mass	0.6	2.6	5.2	0.3	-2.3
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.4	1.2	-0.2
Asthma	0.6	1.2	2.2	0.4	-1.5
Tense / ‘highly strung’	0.6	1.0	1.4	-1.2	-0.8
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	1.6	-0.7	1.3
Eye problems/disorders: None of the above	0.6	0.7	1.4	0.2	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.2	-0.5	1.1
Medication: Aspirin	0.6	0.8	1.4	-1.2	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	0.8	-0.9	0.7
Long-standing illness, disability or infirmity	0.6	0.9	1.3	-1.1	-0.7
Smoking status: Current	0.6	1.0	1.9	0.3	-1.4
Mother’s age at death	0.6	0.7	1.0	1.0	0.7
Illnesses of father: High blood pressure	0.6	0.7	1.2	-0.4	-1.1
Ovarian Cancer	0.5	0.7	0.9	-1.0	-0.7
Age at First Birth	0.5	0.7	1.2	-0.5	1.1
Neuroticism (2016)	0.5	0.7	1.3	0.4	-1.2
Waist Hip Ratio (WHR)	0.5	2.1	2.2	-1.5	1.4
Allergy or Eczema	0.5	1.3	2.4	1.6	-0.4
Cardiovascular Disease	0.5	1.7	2.3	-1.5	-1.1
Hand grip strength (right)	0.5	1.4	2.8	1.7	0.3
Alcohol usually taken with meals	0.5	0.9	1.5	0.5	1.2
Medication: Amlodipine	0.5	0.7	1.3	1.2	0.4
Birth weight	0.5	1.1	2.3	1.5	-0.1
Leg fat percentage (right)	0.5	1.7	1.7	-1.3	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.1	-0.5	-1.1
Qualifications: College or University degree	0.5	1.4	1.6	1.2	1.1
Asthma (self-reported)	0.5	1.1	1.9	0.5	-1.4
Medication: Lisinopril	0.5	0.7	1.0	0.6	-1.0
Leg fat percentage (left)	0.5	1.7	2.1	-1.1	-1.5
Diastolic blood pressure, automated reading	0.5	1.7	3.0	-1.7	-0.6
Alzheimer’s Disease (in mother)	0.4	0.5	0.9	-0.9	0.2
Irritable Bowel Disease (IBD)	0.4	1.0	1.9	-1.4	0.4
Bipolar Disorder (2011)	0.4	0.4	0.7	-0.8	0.0
Rheumatoid Arthritis	0.4	0.6	1.2	-1.1	-0.3
Ulcerative Colitis	0.4	0.6	0.6	0.8	-0.8
Lung FVC	0.4	1.9	2.2	-1.3	1.5
Vitamin and mineral supplements	0.4	0.6	0.7	0.6	-0.9
Medication: Levothyroxine sodium	0.4	0.7	1.2	-1.1	0.5
Mouth/teeth dental problems	0.4	0.6	0.7	-0.7	-0.8
Pain all over the body in last month	0.4	0.4	0.7	-0.1	0.9
Diabetes (self-reported)	0.4	0.6	1.1	-1.0	-0.4
Medication: Simvastatin	0.4	0.5	0.9	0.4	-0.9
Hair/balding pattern: Pattern 3	0.4	0.6	1.0	0.4	1.0
Depression (self-reported)	0.4	0.5	0.8	-0.5	-0.9
Prospective memory result	0.4	0.5	0.6	0.5	0.8
Lung cancer (father)	0.4	0.5	0.9	-0.4	0.9
Body fat percentage	0.4	1.5	2.0	-1.0	-1.4
Health satisfaction	0.4	0.6	1.1	-1.0	-0.3
Shortness of breath walking on level ground	0.4	0.4	0.8	0.9	-0.3
Alcohol intake frequency.	0.4	0.8	0.9	-0.9	-1.0
Hypertension (Self-reported)	0.4	1.2	1.8	-1.4	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	0.7	0.9	-0.9
Diabetes diagnosed by doctor	0.4	0.7	1.3	-1.1	-0.2
Osteoporosis (self-reported)	0.4	0.5	0.5	-0.7	-0.7
Illnesses of father: None of the above (group 1)	0.4	0.5	0.8	0.5	0.9
Medication: Atorvastatin	0.4	0.4	0.7	-0.8	-0.4
Alcohol drinker status: Never	0.4	0.5	0.9	-1.0	-0.0
Ever smoked	0.4	0.8	1.5	0.0	1.2
Schizophrenia (2014)	0.3	0.6	0.7	0.9	0.6
Heel T-Score	0.3	2.1	2.6	-1.6	-1.2
Chronotype (morning person)	0.3	0.7	1.3	1.1	-0.0
Trunk fat percentage	0.3	1.0	1.6	-0.7	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.1	-1.1	-0.6
Hair/balding pattern: Pattern 2	0.3	0.3	0.5	-0.4	-0.7
Neuroticism score	0.3	0.6	1.0	-1.0	-0.5
Number of live births	0.3	0.4	0.6	-0.5	0.8
Standing height	0.3	3.0	5.5	2.3	-0.8
Birth weight of first child	0.3	0.6	0.9	1.0	0.5
Blood clot in the leg (DVT)	0.3	0.4	0.9	0.9	-0.0
Emphysema/chronic bronchitis	0.3	0.3	0.5	0.7	-0.3
Medication: Seretide 50 evohaler	0.3	0.3	0.7	0.8	-0.2
Comparative height size at age 10	0.3	1.6	2.2	1.5	-1.1
Knee pain experienced in last month	0.3	0.5	0.9	-0.1	0.9
Medication: Aspirin	0.3	0.4	0.4	-0.6	-0.6
Medication: Gliclazide	0.3	0.3	0.4	-0.5	0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.5	-0.4	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.6	-0.4	0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	0.9	0.1
Heart disease (siblings)	0.3	0.4	0.6	-0.4	-0.8
Alcohol drinker status: Previous	0.3	0.3	0.3	-0.6	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.9	0.9	-0.4
Schizophrenia (2018)	0.2	0.5	0.6	0.7	0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.6	0.2
Reaction Time	0.2	0.3	0.6	-0.8	0.3
HbA1C	0.2	0.2	0.3	0.6	-0.4
Lupus	0.2	0.2	0.3	-0.5	-0.4
Smoking Status	0.2	0.4	0.5	-0.6	-0.7
Lung FEV1/FVC ratio	0.2	0.8	1.5	0.3	-1.2
Fed-up feelings	0.2	0.3	0.6	0.0	-0.8
High blood pressure	0.2	0.4	0.7	-0.9	0.3
Stomach or abdominal pain in last month	0.2	0.2	0.3	-0.4	0.5
Had menopause	0.2	0.2	0.4	-0.1	-0.6
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.8	0.1
Pulse rate	0.2	0.3	0.4	-0.6	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.0	0.6	-1.0
Headache pain in last month	0.2	0.3	0.4	0.4	-0.6
Comparative body size at age 10	0.2	0.6	1.2	1.1	0.0
Worry too long after embarrassment	0.2	0.3	0.5	0.2	-0.7
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	0.1	-0.8
Medication: Omeprazole	0.2	0.2	0.2	-0.5	0.4
Number of full sisters	0.2	0.2	0.4	0.2	-0.6
Leg pain on walking	0.2	0.2	0.5	0.1	-0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.4	-0.5	0.6
Mood swings	0.2	0.4	0.6	-0.8	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	0.3	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.5	-0.7	0.5
Number of self-reported non-cancer illnesses	0.2	0.4	0.7	-0.8	-0.4
Hearing aid user	0.2	0.2	0.3	0.4	0.6
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.4	0.5	-0.6
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.8	0.3
Supplements: Calcium	0.2	0.3	0.4	0.4	-0.6
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	0.1	0.6
Depressed Affect (Nagel 2018)	0.1	0.3	0.5	-0.2	-0.7
Worry (Nagel 2018)	0.1	0.2	0.3	-0.5	-0.3
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.1	-0.4
HDL Cholesterol	0.1	0.2	0.4	0.2	-0.7
Primary Biliary Cirrhosis	0.1	0.2	0.3	0.1	0.6
Blood Eosinophil Count	0.1	0.4	0.6	-0.7	0.5
Blood Platelet Count	0.1	0.6	1.1	0.5	-1.0
Blood White Count	0.1	0.5	0.6	-0.8	-0.6
Height	0.1	2.6	3.8	1.9	-1.2
Hypothyroidism (self reported)	0.1	0.3	0.5	-0.3	0.7
Neuroticism	0.1	0.3	0.5	-0.7	-0.3
Hair Pigment	0.1	3.3	5.2	1.2	-2.3
Relative age of first facial hair	0.1	0.3	0.3	-0.5	0.5
Townsend deprivation index at recruitment	0.1	0.2	0.2	-0.4	0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	-0.3	0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.5	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	-0.7	-0.4
Medication: Ramipril	0.1	0.1	0.2	0.2	0.5
Worrier / anxious feelings	0.1	0.1	0.1	-0.4	0.3
Happiness	0.1	0.1	0.2	-0.5	-0.3
Noisy workplace	0.1	0.1	0.3	-0.2	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.2	0.3
Hair/balding pattern: Pattern 4	0.1	0.4	0.7	0.8	0.0
Gout (self-reported)	0.1	0.1	0.1	0.3	-0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	0.4	0.3
Forced vital capacity (FVC), Best measure	0.1	0.4	0.5	0.6	-0.7
Number of full brothers	0.1	0.2	0.3	-0.2	0.5
Heart disease (mother)	0.1	0.2	0.3	-0.2	-0.5
Pulse rate, automated reading	0.1	0.3	0.5	-0.7	-0.3
Chest pain or discomfort	0.1	0.2	0.2	-0.3	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.5	0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	0.6	-0.1
Financial situation satisfaction	0.1	0.1	0.2	-0.1	0.5
Age started oral contraceptive pill	0.1	0.2	0.2	0.4	0.4
Ever depressed for a whole week	0.1	0.1	0.2	0.2	0.5
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.3	0.6	0.4
Pain experienced in last month	0.1	0.2	0.3	-0.5	-0.5
Neuroticism (Nagel 2018)	0.0	0.1	0.1	-0.3	-0.3
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	0.0	0.3
Ulcerative Colitis (UC)	0.0	0.0	0.0	-0.2	-0.0
Breast Cancer	0.0	0.1	0.1	0.4	0.2
Respiratory disease	0.0	0.1	0.1	0.3	-0.4
Tanning	0.0	0.2	0.3	-0.3	-0.6
Sensitivity / hurt feelings	0.0	0.1	0.1	-0.1	-0.3
Medication for hormone replacement therapy	0.0	0.0	0.0	-0.1	-0.1
Diabetes (father)	0.0	0.0	0.0	-0.1	-0.0
Multivitamins +/- minerals	0.0	0.0	0.1	-0.1	0.3
High blood pressure (mother)	0.0	0.1	0.1	0.1	-0.3
Nervous feelings	0.0	0.1	0.1	0.0	0.4
Forced vital capacity (FVC)	0.0	0.0	0.0	-0.1	-0.1
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.0	0.1	-0.0
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	-0.2	-0.4
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	-0.0	-0.1
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	0.1	-0.2
Age at first live birth	0.0	0.1	0.2	0.1	0.4
Illnesses of siblings: Diabetes	0.0	0.1	0.1	-0.3	0.0
Back pain experienced in last month	0.0	0.1	0.1	-0.2	-0.3
Guilty feelings	0.0	0.0	0.0	0.0	0.1
Risk taking	0.0	0.1	0.1	0.1	-0.3
Commuting to job workplace: Cycle	0.0	0.1	0.1	0.1	0.3

Hub : Genes

GMPR

Models

Trait associations