Hub : Genes

GMPR

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Small Intestine Terminal Ileum 0.5290 0.1420 0.0043 0.215 NA 0.036 NA 0.123 1.4e-05 NA 5.4e-02 NA 1.1e-03
2 YFS Blood 0.0353 0.0136 0.0027 0.026 0.005 0.018 0.013 0.023 5.5e-09 0.0075 8.3e-07 2.4e-05 5.0e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.6 0.9 1.9 -1.4 -0.1
Bipolar Disorder or Schizophrenia 0.1 0.2 0.3 0.1 0.6
Depressed Affect (Nagel 2018) 0.1 0.3 0.5 -0.2 -0.7
Depression (Nagel 2018) 0.9 1.4 2.4 -1.6 -0.5
Intelligence (Savage-Jansen 2018) 0.2 0.5 0.9 0.9 -0.4
Neuroticism (Nagel 2018) 0.0 0.1 0.1 -0.3 -0.3
Schizophrenia (2018) 0.2 0.5 0.6 0.7 0.8
Schizophrenia vs Biploar Disorder 1.0 1.3 2.0 1.4 0.8
Worry (Nagel 2018) 0.1 0.2 0.3 -0.5 -0.3
Alzheimer’s Disease (in mother) 0.4 0.5 0.9 -0.9 0.2
Alzheimer’s Disease (in father) 0.2 0.2 0.4 0.6 0.2
Alzheimer’s Disease (including proxy) 0.0 0.0 0.1 0.0 0.3
Crohns Disease (2017) 1.7 3.6 6.7 -2.6 0.8
Irritable Bowel Disease (IBD) 0.4 1.0 1.9 -1.4 0.4
Ulcerative Colitis (UC) 0.0 0.0 0.0 -0.2 -0.0
Major Depression (MDD) 1.2 1.5 1.9 -1.4 -1.1
Reaction Time 0.2 0.3 0.6 -0.8 0.3
Verbal and Numeric Reasoning (VNR) 0.6 1.5 2.9 1.7 -0.4
Breast Cancer 0.0 0.1 0.1 0.4 0.2
Ovarian Cancer 0.5 0.7 0.9 -1.0 -0.7
Prostate Cancer 1.2 1.7 2.2 1.1 -1.5
Age at First Birth 0.5 0.7 1.2 -0.5 1.1
Bipolar Disorder (2011) 0.4 0.4 0.7 -0.8 0.0
Body Mass Index (BMI) (2010) 0.7 1.0 1.1 -1.0 -0.9
Coronary Artery Disease (CAD) 0.1 0.1 0.2 0.1 -0.4
Crohns Disease (2012) 1.1 1.7 2.8 -1.7 0.8
Mean Putamen Volume 0.6 0.6 1.1 1.1 -0.4
Fasting Glucose 1.4 1.6 2.9 -1.7 0.7
HbA1C 0.2 0.2 0.3 0.6 -0.4
HDL Cholesterol 0.1 0.2 0.4 0.2 -0.7
LDL Cholesterol 1.6 2.5 4.4 0.8 -2.1
Lupus 0.2 0.2 0.3 -0.5 -0.4
Neuroticism (2016) 0.5 0.7 1.3 0.4 -1.2
Primary Biliary Cirrhosis 0.1 0.2 0.3 0.1 0.6
Rheumatoid Arthritis 0.4 0.6 1.2 -1.1 -0.3
Schizophrenia (2014) 0.3 0.6 0.7 0.9 0.6
Triglycerides 0.7 1.1 1.7 -0.7 1.3
Type 2 Diabetes (T2D) (2012) 3.4 3.9 4.5 1.8 -2.1
Ulcerative Colitis 0.4 0.6 0.6 0.8 -0.8
Blood Eosinophil Count 0.1 0.4 0.6 -0.7 0.5
Blood Platelet Count 0.1 0.6 1.1 0.5 -1.0
Blood Red Count 4.3 41.4 71.9 -3.3 8.5
Blood White Count 0.1 0.5 0.6 -0.8 -0.6
Heel T-Score 0.3 2.1 2.6 -1.6 -1.2
BMI 0.9 5.1 8.5 -1.3 -2.9
Height 0.1 2.6 3.8 1.9 -1.2
Waist Hip Ratio (WHR) 0.5 2.1 2.2 -1.5 1.4
Systolic Blood Pressure 1.1 5.6 9.4 -1.4 3.1
Smoking Status 0.2 0.4 0.5 -0.6 -0.7
Allergy or Eczema 0.5 1.3 2.4 1.6 -0.4
Cardiovascular Disease 0.5 1.7 2.3 -1.5 -1.1
Hypothyroidism (self reported) 0.1 0.3 0.5 -0.3 0.7
Respiratory disease 0.0 0.1 0.1 0.3 -0.4
Type 2 Diabetes (T2D) (2018) 0.8 1.5 2.5 -1.6 -0.7
Lung FEV1/FVC ratio 0.2 0.8 1.5 0.3 -1.2
Lung FVC 0.4 1.9 2.2 -1.3 1.5
Neuroticism 0.1 0.3 0.5 -0.7 -0.3
Chronotype (morning person) 0.3 0.7 1.3 1.1 -0.0
Hair Pigment 0.1 3.3 5.2 1.2 -2.3
Tanning 0.0 0.2 0.3 -0.3 -0.6
Hand grip strength (left) 0.6 1.5 2.8 1.7 0.3
Number of treatments/medications taken 0.8 1.5 2.9 -0.4 -1.7
Average weekly spirits intake 3.3 4.1 4.2 -2.0 2.0
Sensitivity / hurt feelings 0.0 0.1 0.1 -0.1 -0.3
Frequency of depressed mood in last 2 weeks 2.0 2.9 4.8 -2.2 -0.9
Hearing difficulty/problems: Yes 1.6 2.5 4.0 -1.0 2.0
Relative age of first facial hair 0.1 0.3 0.3 -0.5 0.5
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 1.8 0.8 -1.3
Ever used hormone-replacement therapy (HRT) 1.0 1.2 1.4 1.0 -1.2
Ever had hysterectomy (womb removed) 1.3 1.4 2.7 0.5 -1.6
Systolic blood pressure, automated reading 2.1 6.1 6.1 -2.5 2.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 0.9 -0.9 -0.7
Angina 1.2 1.6 1.9 1.4 -1.2
Medication for hormone replacement therapy 0.0 0.0 0.0 -0.1 -0.1
Vitamin and mineral supplements 0.4 0.6 0.7 0.6 -0.9
Supplements: Zinc 1.1 1.2 2.3 0.4 -1.5
Medication: Co-codamol 1.1 1.3 2.2 -1.5 -0.6
Medication: Metformin 1.2 1.7 3.2 -1.8 -0.5
Diabetes (father) 0.0 0.0 0.0 -0.1 -0.0
Diabetes (mother) 3.1 3.9 6.3 1.2 -2.5
Severe depression (siblings) 1.5 1.7 1.8 1.2 -1.3
Pack years adult smoking proportion 2.4 3.6 4.1 2.0 -1.8
Impedance of leg (right) 2.7 13.2 16.5 -3.1 4.1
Leg fat-free mass (left) 2.5 13.5 20.2 2.6 -4.5
Trunk fat percentage 0.3 1.0 1.6 -0.7 -1.3
Hand grip strength (right) 0.5 1.4 2.8 1.7 0.3
Townsend deprivation index at recruitment 0.1 0.2 0.2 -0.4 0.4
Current tobacco smoking 0.6 1.0 1.4 0.7 -1.2
Average weekly fortified wine intake 1.6 1.8 3.6 -1.9 0.1
Maternal smoking around birth 1.1 1.7 2.9 1.7 -0.6
Fed-up feelings 0.2 0.3 0.6 0.0 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.3 3.3 -1.8 -1.2
Relative age voice broke 1.7 2.6 3.2 -1.4 1.8
Taking other prescription medications 0.8 1.3 1.7 -0.9 -1.3
Age when periods started (menarche) 1.6 3.8 7.3 -0.5 2.7
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.1 -0.3 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.1 -1.1 -0.6
Tinnitus: Yes, but not now, but have in the past 2.1 2.3 3.0 1.2 -1.7
Qualifications: CSEs or equivalent 0.6 0.8 1.4 -1.2 0.4
Serious illness, injury or assault to yourself 0.1 0.1 0.3 -0.5 -0.1
High blood pressure 0.2 0.4 0.7 -0.9 0.3
Hayfever, allergic rhinitis or eczema 1.1 2.5 4.8 2.2 -0.4
Multivitamins +/- minerals 0.0 0.0 0.1 -0.1 0.3
Stomach or abdominal pain in last month 0.2 0.2 0.3 -0.4 0.5
Supplements: Glucosamine 1.0 1.3 2.4 0.5 -1.6
Diverticular disease/diverticulitis (self-reported) 1.8 2.1 3.2 1.0 -1.8
Medication: Atenolol 1.1 1.3 1.5 -1.1 -1.2
Medication: Levothyroxine sodium 0.4 0.7 1.2 -1.1 0.5
Sitting height 0.6 4.6 5.4 1.9 -2.3
Chronic bronchitis/emphysema (father) 0.9 1.0 1.4 -0.8 -1.2
High blood pressure (mother) 0.0 0.1 0.1 0.1 -0.3
Body mass index (BMI) 1.7 7.1 14.1 0.4 -3.8
Impedance of leg (left) 2.5 12.3 16.0 -2.9 4.0
Leg predicted mass (left) 2.6 13.6 20.3 2.6 -4.5
Trunk fat mass 0.6 2.6 5.2 0.3 -2.3
Waist circumference 1.1 4.2 8.2 -0.4 -2.9
Number of incorrect matches in round 0.7 1.2 2.4 -0.1 1.5
Past tobacco smoking 0.9 1.7 2.8 0.8 -1.7
Alcohol usually taken with meals 0.5 0.9 1.5 0.5 1.2
Nervous feelings 0.0 0.1 0.1 0.0 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 2.0 -0.7 -1.4
Hearing difficulty/problems with background noise 1.8 2.8 5.1 -0.8 2.2
Hair/balding pattern: Pattern 2 0.3 0.3 0.5 -0.4 -0.7
Had menopause 0.2 0.2 0.4 -0.1 -0.6
Had other major operations 1.3 1.6 2.1 1.0 -1.5
Forced vital capacity (FVC) 0.0 0.0 0.0 -0.1 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.5 -0.7 -0.4
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.4 1.2 -0.2
Qualifications: None of the above 1.3 2.7 5.1 -2.3 0.6
Financial difficulties in last 2 years 1.4 1.8 3.6 -0.1 -1.9
Mouth/teeth dental problems 0.4 0.6 0.7 -0.7 -0.8
Heart attack 2.1 2.7 4.8 0.8 -2.2
Allergy 0.7 1.7 2.0 -1.4 1.2
Pain all over the body in last month 0.4 0.4 0.7 -0.1 0.9
Diabetes (self-reported) 0.4 0.6 1.1 -1.0 -0.4
Hayfever/allergic rhinitis (self-reported) 0.0 0.0 0.0 0.1 -0.0
Medication: Ramipril 0.1 0.1 0.2 0.2 0.5
Medication: Simvastatin 0.4 0.5 0.9 0.4 -0.9
Fluid intelligence score 0.8 1.7 2.4 1.6 -1.0
Illnesses of siblings 0.8 1.1 2.2 0.0 1.5
Neuroticism score 0.3 0.6 1.0 -1.0 -0.5
Weight 1.6 7.9 14.1 1.3 -3.8
Impedance of arm (right) 1.8 8.6 12.0 -2.3 3.5
Arm fat percentage (right) 0.8 3.0 5.8 -0.5 -2.4
Trunk fat-free mass 2.3 13.0 19.2 2.6 -4.4
Hip circumference 2.0 8.8 16.6 1.0 -4.1
Time employed in main current job 3.4 3.9 4.9 -2.2 1.7
Alcohol intake versus 10 years previously 0.2 0.3 0.6 -0.8 0.1
Father’s age at death 1.1 1.5 2.1 0.9 1.4
Worrier / anxious feelings 0.1 0.1 0.1 -0.4 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 1.3 -1.1 -0.9
Falls in the last year 0.9 1.2 2.3 -1.5 -0.1
Hair/balding pattern: Pattern 3 0.4 0.6 1.0 0.4 1.0
Number of live births 0.3 0.4 0.6 -0.5 0.8
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.2 -0.2 -0.4
Pulse rate 0.2 0.3 0.4 -0.6 0.4
Happiness 0.1 0.1 0.2 -0.5 -0.3
Noisy workplace 0.1 0.1 0.3 -0.2 0.5
Qualifications: A levels/AS levels or equivalent 0.7 1.6 2.5 0.9 -1.6
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.1 -0.2 0.3
Mouth/teeth dental problems: Dentures 0.0 0.0 0.0 -0.0 -0.1
Asthma 0.6 1.2 2.2 0.4 -1.5
Medication: Ibuprofen (e.g. Nurofen) 1.7 2.2 4.0 0.5 -2.0
Medication: Cholesterol lowering 3.8 6.0 7.3 2.7 -2.1
Depression (self-reported) 0.4 0.5 0.8 -0.5 -0.9
Medication: Lansoprazole 0.7 0.8 1.1 -1.1 0.8
Prospective memory result 0.4 0.5 0.6 0.5 0.8
Lung cancer (father) 0.4 0.5 0.9 -0.4 0.9
Illnesses of mother 0.8 1.0 1.5 -1.2 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.0 0.6 -1.0
Pulse wave Arterial Stiffness index 1.9 2.2 2.8 -1.3 1.7
Impedance of arm (left) 2.0 9.3 13.5 -2.2 3.7
Arm fat mass (right) 1.4 5.8 11.6 0.3 -3.4
Trunk predicted mass 2.2 12.7 19.0 2.5 -4.4
Standing height 0.3 3.0 5.5 2.3 -0.8
Length of working week for main job 0.7 0.8 0.9 0.8 -1.0
Exposure to tobacco smoke at home 1.0 1.1 1.2 1.0 -1.1
Breastfed as a baby 0.8 0.9 1.8 1.4 0.2
Tense / ‘highly strung’ 0.6 1.0 1.4 -1.2 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 2.4 -0.8 -1.5
Hair/balding pattern: Pattern 4 0.1 0.4 0.7 0.8 0.0
Birth weight of first child 0.3 0.6 0.9 1.0 0.5
Peak expiratory flow (PEF) 1.6 3.7 6.0 1.2 -2.4
Pulse wave reflection index 1.3 1.6 2.3 -1.5 1.0
Ever highly irritable/argumentative for 2 days 0.9 1.1 1.4 0.9 -1.2
Loud music exposure frequency 2.1 2.3 2.7 1.4 -1.6
Qualifications: O levels/GCSEs or equivalent 2.5 3.9 4.5 1.8 -2.1
Mouth/teeth dental problems: Bleeding gums 3.1 4.1 8.1 -0.1 2.8
Blood clot in the leg (DVT) 0.3 0.4 0.9 0.9 -0.0
Medication: Paracetamol 1.1 1.8 3.5 0.4 -1.9
Headache pain in last month 0.2 0.3 0.4 0.4 -0.6
Medication for cholesterol, blood pressure or diabetes 3.2 5.4 6.5 -2.6 2.1
Glaucoma (self-reported) 1.2 1.5 2.4 1.6 -0.7
Gout (self-reported) 0.1 0.1 0.1 0.3 -0.3
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 1.6 -0.7 1.3
Medication: Amlodipine 0.5 0.7 1.3 1.2 0.4
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.1 0.4 0.3
Birth weight 0.5 1.1 2.3 1.5 -0.1
Chronic bronchitis/emphysema (mother) 0.0 0.0 0.0 0.1 -0.2
High blood pressure (siblings) 1.8 2.6 4.6 0.8 -2.1
Forced vital capacity (FVC), Best measure 0.1 0.4 0.5 0.6 -0.7
Body fat percentage 0.4 1.5 2.0 -1.0 -1.4
Leg fat percentage (right) 0.5 1.7 1.7 -1.3 -1.3
Arm fat-free mass (right) 2.4 12.2 18.2 2.5 -4.3
Exposure to tobacco smoke outside home 0.9 1.2 1.7 -0.9 -1.3
Comparative body size at age 10 0.2 0.6 1.2 1.1 0.0
Number of full brothers 0.1 0.2 0.3 -0.2 0.5
Worry too long after embarrassment 0.2 0.3 0.5 0.2 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.1 -0.5 -1.1
Wheeze or whistling in the chest in last year 0.2 0.3 0.6 0.1 -0.8
Number of children fathered 0.7 0.8 1.5 0.4 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 1.5 -0.8 1.2
Age at first live birth 0.0 0.1 0.2 0.1 0.4
Pulse wave peak to peak time 1.9 2.2 2.7 1.3 -1.6
Health satisfaction 0.4 0.6 1.1 -1.0 -0.3
Shortness of breath walking on level ground 0.4 0.4 0.8 0.9 -0.3
Qualifications: College or University degree 0.5 1.4 1.6 1.2 1.1
Eye problems/disorders: None of the above 0.6 0.7 1.4 0.2 1.2
Mouth/teeth dental problems: Loose teeth 0.7 0.9 1.1 -1.0 0.8
Emphysema/chronic bronchitis 0.3 0.3 0.5 0.7 -0.3
Medication for pain relief, constipation, heartburn 1.8 3.1 5.8 -0.6 2.4
Neck or shoulder pain in last month 2.1 3.0 6.0 -2.5 0.2
Medication: Blood pressure 0.8 1.4 2.2 1.5 -0.8
Angina (self-reported) 1.5 1.9 1.9 1.4 -1.4
Migraine (self-reported) 1.0 1.3 2.3 0.5 -1.5
Medication: Ibuprofen 1.8 2.2 3.6 0.8 -1.9
Medication: Allopurinol 1.0 1.4 1.6 1.3 -1.1
Medication: Omeprazole 0.2 0.2 0.2 -0.5 0.4
Medication: Seretide 50 evohaler 0.3 0.3 0.7 0.8 -0.2
Mean time to correctly identify matches 1.1 2.0 3.6 -0.7 1.9
Heart disease (mother) 0.1 0.2 0.3 -0.2 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 1.5 1.2 -1.1
Whole body fat mass 0.9 3.7 7.4 0.1 -2.7
Leg fat mass (right) 0.9 3.5 7.0 -0.0 -2.6
Arm predicted mass (right) 2.2 11.5 17.4 2.4 -4.2
Pulse rate, automated reading 0.1 0.3 0.5 -0.7 -0.3
Alcohol intake frequency. 0.4 0.8 0.9 -0.9 -1.0
Comparative height size at age 10 0.3 1.6 2.2 1.5 -1.1
Number of full sisters 0.2 0.2 0.4 0.2 -0.6
Suffer from ‘nerves’ 0.7 1.1 2.2 -1.5 -0.2
Overall health rating 1.4 3.0 4.3 -2.1 -1.3
Chest pain or discomfort 0.1 0.2 0.2 -0.3 -0.5
Had major operations 5.0 5.9 8.3 1.9 -2.9
Age at last live birth 1.1 1.6 2.8 -1.7 0.6
Family relationship satisfaction 1.6 1.9 2.7 -1.1 1.6
Leg pain on walking 0.2 0.2 0.5 0.1 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.2 -0.5 1.1
Commuting to job workplace: Car/motor vehicle 1.7 1.9 3.3 -0.7 1.8
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.4 -0.5 0.6
Medication: Aspirin 0.6 0.8 1.4 -1.2 -0.3
Supplements: Vitamin C 1.0 1.2 1.9 -1.4 -0.6
Knee pain experienced in last month 0.3 0.5 0.9 -0.1 0.9
Hypertension (Self-reported) 0.4 1.2 1.8 -1.4 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 0.8 -0.9 0.7
Illnesses of father: Heart disease 1.1 1.5 2.4 0.8 -1.5
Illnesses of siblings: Diabetes 0.0 0.1 0.1 -0.3 0.0
Smoking status: Previous 1.9 2.9 4.8 -1.0 2.2
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.7 0.7 0.9 -0.9
Whole body fat-free mass 2.4 13.6 20.4 2.6 -4.5
Leg fat-free mass (right) 2.7 14.4 20.3 2.9 -4.5
Arm fat percentage (left) 0.8 3.1 6.1 -0.3 -2.5
Average weekly red wine intake 1.0 1.5 2.1 0.9 -1.5
Handedness (chirality/laterality): Left-handed 3.7 4.5 6.8 -1.5 2.6
Mood swings 0.2 0.4 0.6 -0.8 0.4
Loneliness, isolation 2.8 3.8 7.3 -2.7 -0.5
Long-standing illness, disability or infirmity 0.6 0.9 1.3 -1.1 -0.7
Ever had bowel cancer screening 1.4 1.6 3.1 -0.2 1.8
Diabetes diagnosed by doctor 0.4 0.7 1.3 -1.1 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 0.5 0.2
Friendships satisfaction 2.0 2.5 4.9 0.0 2.2
Qualifications: nursing, teaching 1.1 1.7 3.4 1.9 -0.1
Commuting to job workplace: Walk 1.7 1.8 1.9 1.4 1.3
Eye problems/disorders: Cataract 1.7 2.0 3.9 -2.0 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.3 0.6 -0.1
Medication for cholesterol 1.2 1.9 3.0 1.7 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.3 0.3 0.6
Back pain experienced in last month 0.0 0.1 0.1 -0.2 -0.3
Mineral and other dietary supplements 0.7 0.9 1.5 -0.6 1.2
Breast cancer (self-reported) 1.9 2.2 2.6 -1.6 -1.4
Asthma (self-reported) 0.5 1.1 1.9 0.5 -1.4
Osteoporosis (self-reported) 0.4 0.5 0.5 -0.7 -0.7
Osteoarthritis (self-reported) 1.0 1.3 1.5 -1.0 1.2
Medication: Aspirin 0.3 0.4 0.4 -0.6 -0.6
Medication: Gliclazide 0.3 0.3 0.4 -0.5 0.7
Illnesses of father: None of the above (group 1) 0.4 0.5 0.8 0.5 0.9
Smoking status: Current 0.6 1.0 1.9 0.3 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.5 -0.7 0.5
Whole body water mass 2.5 14.4 21.3 2.7 -4.6
Leg predicted mass (right) 2.8 14.9 21.2 2.9 -4.6
Arm fat mass (left) 1.4 5.8 11.6 0.3 -3.4
Number of self-reported non-cancer illnesses 0.2 0.4 0.7 -0.8 -0.4
Average weekly champagne plus white wine intake 2.2 3.0 5.6 2.4 0.6
Miserableness 1.9 3.3 5.6 1.0 -2.4
Guilty feelings 0.0 0.0 0.0 0.0 0.1
Wears glasses or contact lenses 0.7 0.8 1.6 0.1 1.2
Ever taken oral contraceptive pill 0.9 1.0 1.1 -1.1 0.9
Hearing aid user 0.2 0.2 0.3 0.4 0.6
Mother’s age at death 0.6 0.7 1.0 1.0 0.7
Financial situation satisfaction 0.1 0.1 0.2 -0.1 0.5
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.4 0.5 -0.6
Commuting to job workplace: Public transport 1.1 1.3 2.0 1.4 -0.8
Eye problems/disorders: Glaucoma 0.8 0.9 1.2 1.1 -0.8
Medication: Blood pressure 2.0 3.8 4.5 -2.1 1.8
Pain type(s) experienced in last month: Hip pain 0.3 0.3 0.5 -0.4 -0.7
Supplements: Fish oil (including cod liver oil) 0.9 1.2 2.1 0.4 -1.5
High cholesterol (Self-reported) 0.8 1.5 2.7 0.5 -1.6
Medication: Bendroflumethiazide 0.2 0.3 0.6 -0.8 0.3
Medication: Paracetamol 1.8 2.8 4.6 1.0 -2.1
Medication: Lisinopril 0.5 0.7 1.0 0.6 -1.0
Medication: Atorvastatin 0.4 0.4 0.7 -0.8 -0.4
Illnesses of father: High blood pressure 0.6 0.7 1.2 -0.4 -1.1
Alcohol drinker status: Never 0.4 0.5 0.9 -1.0 -0.0
Ever smoked 0.4 0.8 1.5 0.0 1.2
Basal metabolic rate 2.3 12.6 19.9 2.3 -4.5
Leg fat percentage (left) 0.5 1.7 2.1 -1.1 -1.5
Arm fat-free mass (left) 2.2 10.9 18.1 1.9 -4.3
Number of operations (self-reported) 3.2 4.7 6.3 1.7 -2.5
Average weekly beer plus cider intake 0.9 1.3 2.3 -0.5 -1.5
Irritability 1.3 2.2 3.4 -1.8 1.0
Risk taking 0.0 0.1 0.1 0.1 -0.3
Ever had prostate specific antigen (PSA) test 3.2 3.7 6.7 2.6 -0.9
Fractured/broken bones in last 5 years 0.8 1.0 1.9 -0.3 -1.4
Age started oral contraceptive pill 0.1 0.2 0.2 0.4 0.4
Diastolic blood pressure, automated reading 0.5 1.7 3.0 -1.7 -0.6
Ever depressed for a whole week 0.1 0.1 0.2 0.2 0.5
Unable to work because of sickness or disability 1.1 1.4 2.2 -1.5 -0.8
Commuting to job workplace: Cycle 0.0 0.1 0.1 0.1 0.3
Myopia 0.9 1.3 2.6 1.6 0.3
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.3 0.6 0.4
Cholesterol lowering medication 0.9 1.4 2.4 -1.5 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.6 -0.4 0.8
Pain experienced in last month 0.1 0.2 0.3 -0.5 -0.5
Supplements: Calcium 0.2 0.3 0.4 0.4 -0.6
Basal cell carcinoma (self-reported) 1.7 2.0 3.5 -0.7 1.9
Heart attack/myocardial infarction (self-reported) 1.3 1.6 2.8 0.7 -1.7
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.7 0.9 0.1
Heart disease (siblings) 0.3 0.4 0.6 -0.4 -0.8
Alcohol drinker status: Previous 0.3 0.3 0.3 -0.6 -0.5
Pack years of smoking 1.7 2.5 3.7 1.9 -1.1
Impedance of whole body 2.3 11.8 16.5 -2.7 4.1
Leg fat mass (left) 1.0 3.9 7.8 0.1 -2.8
Arm predicted mass (left) 2.4 12.1 19.1 2.2 -4.4