TWAS hub - GNAO1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.4470	0.0670	8.4e-13	0.485	NA	0.435	NA	0.469	5.3e-30	NA	4.9e-26	NA	1.1e-28
2	GTEx	Artery Tibial	0.1331	0.0431	1.5e-05	0.120	NA	0.084	NA	0.110	1.2e-09	NA	4.1e-07	NA	6.0e-09
3	GTEx	Esophagus Muscularis	0.0930	0.0360	1.2e-03	0.027	NA	0.030	NA	0.063	9.1e-03	NA	6.3e-03	NA	1.1e-04
4	GTEx	Muscle Skeletal	0.0584	0.0255	7.5e-03	-0.003	NA	-0.003	NA	0.004	8.6e-01	NA	9.1e-01	NA	1.1e-01
5	TCGA	Esophageal Carcinoma	0.2070	0.1000	8.7e-03	-0.001	0.078	0.023	NA	0.004	3.5e-01	0.0018	6.3e-02	NA	2.3e-01
6	TCGA	Prostate Adenocarcinoma	0.0559	0.0340	3.4e-03	0.003	0.011	0.002	NA	0.010	1.5e-01	0.0200	1.9e-01	NA	2.9e-02
7	TCGA	Thyroid Carcinoma	0.0360	0.0200	6.4e-03	0.025	0.016	0.016	NA	0.018	1.5e-03	0.0094	8.9e-03	NA	6.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Reaction Time	8.4	16.0	28.9	3.7	5.4	3.1	-4.8	-1.6	4.8	-3.4
Handedness (chirality/laterality): Left-handed	8.1	9.8	17.1	2.1	3.2	2.7	-4.1	-2.9	3.5	-2.9
Mean time to correctly identify matches	6.8	12.9	24.9	3.9	5.0	3.0	-4.0	-0.7	4.3	-2.5
Prospective memory result	6.2	7.6	12.4	2.6	3.5	1.9	-3.0	0.8	3.4	-3.0
Impedance of leg (left)	6.0	29.1	41.7	4.7	6.3	5.2	-6.5	3.6	6.0	-4.8
Diastolic blood pressure, automated reading	5.4	16.7	27.2	-4.6	-3.9	-5.2	2.2	-4.9	-4.5	2.0
Impedance of leg (right)	4.8	23.3	30.7	4.5	5.5	5.0	-5.5	3.5	5.3	-4.2
Blood clot in the leg (DVT)	4.8	6.2	10.6	-2.3	-3.0	-2.2	3.1	-0.2	-3.3	1.8
Deep venous thrombosis (DVT) (self-reported)	4.6	5.9	11.0	-2.3	-3.1	-2.3	3.0	-0.3	-3.3	1.4
Alcohol drinker status: Never	4.4	5.2	7.8	-2.1	-2.4	-2.3	2.8	-1.5	-1.9	2.7
Impedance of whole body	3.8	19.3	28.5	3.9	5.0	4.5	-5.3	3.4	4.5	-3.7
Serious illness, injury or assault of a close relative in last 2 years	3.7	4.2	10.6	-1.0	-2.2	-1.5	2.7	-0.4	-1.9	3.2
Mineral and other dietary supplements	3.6	4.8	10.2	1.8	2.9	1.8	-3.2	-0.1	1.5	-2.6
Worry too long after embarrassment	3.4	5.7	10.5	-2.9	-2.5	-1.9	2.0	-1.2	-2.4	3.2
Stomach or abdominal pain in last month	3.3	4.1	6.0	2.0	2.3	1.7	-2.1	2.4	2.4	-0.6
Hayfever/allergic rhinitis (self-reported)	3.2	4.3	11.2	2.7	1.4	3.3	-0.1	1.8	2.4	-0.9
Heart disease (siblings)	3.2	3.9	7.6	-1.6	-1.6	-1.6	2.1	-2.8	-1.8	2.2
Eye problems/disorders: Diabetes related eye disease	3.1	3.4	5.9	-1.8	-1.6	-1.0	1.5	-2.4	-1.8	2.4
Pain experienced in last month	3.0	5.1	8.0	2.7	2.2	2.8	-1.8	-0.7	2.5	-2.2
Exposure to tobacco smoke at home	2.9	3.3	6.5	2.5	1.8	1.8	-1.5	1.7	1.8	-1.0
Verbal and Numeric Reasoning (VNR)	2.8	6.7	14.1	-1.5	-3.1	-1.7	3.7	-0.4	-2.1	3.8
Smoking Status	2.8	6.8	9.8	3.1	3.1	2.4	-3.0	1.4	2.6	-2.2
Ever used hormone-replacement therapy (HRT)	2.8	3.6	5.3	1.7	1.9	1.8	-2.0	1.8	1.6	-2.3
Leg fat-free mass (left)	2.8	14.6	16.1	-3.3	-4.0	-3.9	4.0	-3.9	-4.0	3.8
Long-standing illness, disability or infirmity	2.8	4.2	9.4	-2.6	-1.9	-2.4	1.1	-0.2	-3.1	1.6
Guilty feelings	2.8	4.1	6.7	-2.5	-1.5	-2.6	0.8	-2.2	-2.1	1.9
Current tobacco smoking	2.7	4.4	13.3	1.3	2.8	0.8	-3.6	-0.2	2.3	-1.5
Leg predicted mass (left)	2.7	14.6	15.7	-3.2	-3.9	-4.0	3.9	-3.9	-4.0	3.8
Leg fat-free mass (right)	2.7	14.3	15.8	-3.4	-3.9	-4.0	3.8	-3.9	-3.9	3.6
Leg predicted mass (right)	2.7	14.4	16.2	-3.4	-3.9	-4.0	3.7	-3.9	-3.9	3.6
Crohns Disease (2017)	2.6	5.7	9.5	2.3	2.8	2.7	-3.1	-0.7	1.9	-2.4
Primary Biliary Cirrhosis	2.4	3.4	8.5	1.2	2.0	2.0	-2.0	-0.1	1.4	-2.9
Qualifications: CSEs or equivalent	2.4	3.1	11.3	0.7	1.2	1.1	-2.3	1.0	1.2	-3.4
Fluid intelligence score	2.4	5.0	11.4	-1.3	-2.6	-1.8	2.9	-0.2	-1.8	3.4
Qualifications: O levels/GCSEs or equivalent	2.4	3.8	8.3	-1.8	-2.2	-0.5	2.0	-0.9	-2.2	2.9
Mouth/teeth dental problems: Loose teeth	2.4	2.8	5.9	-2.2	-1.7	-2.4	0.5	-1.2	-2.1	0.4
Diabetes diagnosed by doctor	2.4	4.0	9.0	-2.2	-2.1	-1.8	2.1	-0.5	-3.0	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.4	5.1	11.9	2.6	2.5	2.2	-2.1	-0.4	3.4	-1.2
Supplements: Fish oil (including cod liver oil)	2.4	3.1	5.9	-1.9	-2.1	-1.8	2.4	-0.6	-1.8	0.9
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	6.4	0.6	1.8	0.9	-2.1	2.5	0.9	-2.1
Breast Cancer	2.3	5.6	12.5	-1.5	-2.4	-3.5	2.0	-1.6	-2.2	2.8
Crohns Disease (2012)	2.3	3.8	5.9	1.8	2.4	2.0	-2.4	-1.7	1.8	-1.1
Osteoarthritis (self-reported)	2.3	3.0	6.7	-1.6	-1.4	-1.2	1.8	-1.1	-2.0	2.6
Smoking status: Current	2.3	3.6	11.4	1.1	2.5	0.4	-3.4	-0.1	2.0	-1.4
Irritable Bowel Disease (IBD)	2.2	5.3	8.6	1.9	2.6	2.6	-2.9	-0.3	1.9	-2.8
Average weekly spirits intake	2.2	2.7	5.3	0.9	2.3	1.1	-2.3	-0.1	2.1	-1.5
Medication for hormone replacement therapy	2.2	2.4	4.3	1.3	1.1	2.0	-0.6	1.8	1.4	-2.1
Medication: Metformin	2.2	3.1	5.8	-1.8	-1.8	-1.7	1.9	-0.8	-2.4	1.6
Ever taken oral contraceptive pill	2.2	2.4	5.1	1.3	1.6	1.7	-2.3	0.2	1.5	-1.5
Type 2 Diabetes (T2D) (2018)	2.1	3.8	9.3	-2.0	-2.0	-2.1	2.1	-0.1	-3.0	0.9
Time employed in main current job	2.1	2.4	8.0	0.1	-1.7	0.3	2.8	0.7	-1.2	2.1
Hair/balding pattern: Pattern 3	2.1	3.1	4.8	2.1	2.0	2.2	-1.2	0.9	2.0	-1.4
Medication: Omeprazole	2.1	2.5	8.3	1.0	1.4	1.0	-1.3	2.9	0.9	-1.6
Whole body fat-free mass	2.1	11.8	14.8	-2.6	-3.7	-3.4	3.9	-3.4	-3.2	3.8
Whole body water mass	2.1	12.0	15.2	-2.7	-3.7	-3.4	3.9	-3.4	-3.2	3.8
Average weekly champagne plus white wine intake	2.1	2.9	5.0	2.1	1.4	2.2	-1.1	1.6	1.5	-1.7
Basal metabolic rate	2.1	11.6	13.4	-2.8	-3.5	-3.5	3.5	-3.7	-3.3	3.5
Supplements: Calcium	2.1	2.3	6.0	-0.8	-1.5	-0.8	2.4	1.4	-1.2	1.8
Mean Putamen Volume	2.0	2.3	5.1	-1.0	-1.9	-1.1	1.9	0.7	-1.1	2.3
Chronotype (morning person)	2.0	4.6	9.2	3.0	0.6	2.2	-0.7	2.9	2.3	-1.9
Tinnitus: Yes, but not now, but have in the past	2.0	2.2	6.9	1.4	1.0	0.9	-1.1	1.7	0.7	-2.6
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	4.0	1.4	1.5	1.7	-0.8	1.9	2.0	-1.1
Osteoporosis (self-reported)	2.0	2.4	5.2	-1.4	-1.4	-1.9	1.1	-0.1	-2.3	1.8
Tinnitus: Yes, now most or all of the time	2.0	2.3	4.0	1.1	1.3	1.4	-1.6	1.9	0.9	-2.0
Intelligence (Savage-Jansen 2018)	1.9	5.9	15.5	-1.2	-2.7	-1.6	3.4	-0.6	-1.8	3.9
Average weekly fortified wine intake	1.9	2.3	4.8	2.1	1.0	1.9	-0.3	-0.2	2.2	1.4
Age when periods started (menarche)	1.9	4.6	11.9	1.3	2.5	2.0	-2.2	1.2	1.3	-3.5
Trunk fat-free mass	1.9	10.8	15.2	-2.4	-3.7	-3.2	3.9	-2.9	-2.9	3.8
Trunk predicted mass	1.9	10.8	15.5	-2.3	-3.7	-3.1	3.9	-2.8	-2.8	3.9
Headache pain in last month	1.9	3.3	10.4	-1.9	-1.7	-1.3	1.5	0.9	-1.1	3.2
Back pain experienced in last month	1.9	2.8	4.5	-2.1	-1.7	-1.9	1.7	-0.3	-1.8	1.5
Neuroticism (2016)	1.8	2.6	4.9	-2.2	-1.6	-1.1	1.7	1.3	-2.1	0.3
Hayfever, allergic rhinitis or eczema	1.8	3.8	7.3	2.2	2.3	2.7	-1.3	0.9	2.5	0.3
Body mass index (BMI)	1.8	7.5	14.7	-2.5	-2.2	-3.2	1.9	-3.8	-3.1	1.6
Diabetes (self-reported)	1.8	2.8	6.9	-1.8	-1.8	-1.3	1.9	-0.7	-2.6	0.9
Noisy workplace	1.8	2.2	12.9	0.2	0.7	-0.1	-1.4	-0.0	0.0	-3.6
Allergy or Eczema	1.7	4.6	9.1	2.6	2.3	3.0	-0.9	1.9	2.5	0.4
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	5.6	0.4	2.1	1.6	-2.4	-1.2	1.2	-0.5
Had other major operations	1.7	2.1	4.4	1.1	-0.6	1.2	1.9	2.0	0.2	2.1
Weight	1.7	8.6	15.4	-2.6	-2.4	-3.4	2.1	-3.9	-3.2	2.4
Ever had bowel cancer screening	1.7	2.0	7.7	1.6	0.5	1.4	-0.1	2.8	0.7	-0.9
Type 2 Diabetes (T2D) (2012)	1.6	1.8	2.9	-1.0	-1.3	-1.6	1.1	-1.7	-1.6	0.8
Pain all over the body in last month	1.6	1.7	4.2	0.4	1.6	1.3	-2.1	-1.5	1.2	0.3
Qualifications: A levels/AS levels or equivalent	1.6	3.7	9.1	-1.4	-2.0	-0.4	2.6	0.8	-1.8	3.0
Tense / ‘highly strung’	1.6	2.6	5.5	1.0	1.6	2.4	-1.6	0.9	1.9	-1.4
Comparative body size at age 10	1.6	4.4	8.5	-1.8	-1.9	-1.9	1.6	-2.9	-1.2	2.9
Pain type(s) experienced in last month: Hip pain	1.6	2.0	3.8	-1.7	-1.3	-1.4	1.0	0.5	-1.5	2.0
BMI	1.5	8.8	14.1	-2.9	-2.6	-3.5	2.3	-3.5	-3.8	1.6
Supplements: Zinc	1.5	1.6	4.4	-0.8	-1.5	-0.9	2.1	-0.4	-0.9	1.5
Waist circumference	1.5	5.3	10.7	-2.1	-1.7	-2.7	1.6	-3.3	-2.6	1.7
Supplements: Vitamin C	1.5	1.8	3.3	-1.5	-1.5	-1.8	1.7	0.1	-1.2	0.7
Rheumatoid Arthritis	1.4	2.0	3.3	-1.2	-1.4	-1.4	1.6	1.8	-1.6	0.3
Had menopause	1.4	1.7	3.6	1.9	1.8	1.3	-0.6	1.5	0.7	-0.6
Hip circumference	1.4	6.1	17.5	-2.4	-1.6	-2.8	0.8	-4.2	-2.6	1.4
Falls in the last year	1.4	1.9	4.5	-1.0	-1.8	-0.7	2.1	0.8	-1.9	-0.5
Illnesses of mother	1.4	1.8	3.4	1.8	1.3	1.7	-0.9	1.1	1.2	-1.0
Arm fat mass (right)	1.4	5.8	14.7	-2.2	-1.6	-2.7	1.2	-3.8	-2.7	1.5
Glaucoma (self-reported)	1.4	1.6	4.1	1.3	0.6	1.7	0.0	2.0	1.5	-0.4
Heart disease (mother)	1.4	1.7	3.5	-1.8	-0.5	-1.9	-0.2	-1.2	-0.9	1.6
Eye problems/disorders: Cataract	1.4	1.7	3.8	1.2	1.1	2.0	-0.8	1.0	1.3	-1.4
Arm fat-free mass (left)	1.4	6.9	11.7	-2.1	-2.4	-2.8	2.5	-3.4	-2.4	2.6
Average weekly beer plus cider intake	1.4	2.0	5.8	-1.6	-1.6	-2.4	0.8	-0.1	-1.1	0.9
Supplements: Glucosamine	1.3	1.7	3.0	-0.9	-1.7	-1.0	1.7	-0.9	-0.9	1.5
Father’s age at death	1.3	1.7	6.1	1.0	-0.6	0.4	1.9	2.5	-0.2	1.0
Overall health rating	1.3	2.8	5.6	-2.2	-1.0	-1.7	1.1	-1.1	-1.7	2.4
Illnesses of father: Heart disease	1.3	1.7	3.1	1.2	1.7	1.5	-1.1	-0.9	1.8	0.4
Arm fat mass (left)	1.3	5.4	13.8	-2.1	-1.6	-2.6	1.2	-3.7	-2.6	1.5
Hearing aid user	1.3	1.4	4.5	1.3	1.2	2.1	-0.9	0.2	0.8	-1.0
Commuting to job workplace: Cycle	1.3	1.5	2.9	-0.6	-1.5	-1.3	1.7	-0.5	-1.2	1.3
Severe depression (siblings)	1.2	1.4	2.9	-0.8	-0.9	-0.9	1.0	1.7	-1.3	1.3
Taking other prescription medications	1.2	1.8	3.5	1.1	1.7	1.9	-1.6	0.3	1.3	-1.0
Chronic bronchitis/emphysema (father)	1.2	1.4	3.8	-0.8	-1.1	-0.5	1.3	-1.3	-2.0	0.7
Alcohol usually taken with meals	1.2	2.0	5.0	2.2	0.3	1.8	0.0	1.4	1.8	-0.2
Impedance of arm (right)	1.2	5.7	9.6	2.0	2.5	2.8	-3.1	2.0	2.2	-1.8
Happiness	1.2	1.5	4.9	-2.2	-0.3	-1.2	-1.0	-1.5	-0.5	0.7
Mouth/teeth dental problems: Dentures	1.2	1.9	4.8	-2.1	-0.6	-1.7	0.2	-2.2	-1.1	0.3
Impedance of arm (left)	1.2	5.8	9.7	2.0	2.7	2.6	-3.1	2.3	2.2	-1.6
Leg fat mass (right)	1.2	4.6	12.9	-1.9	-1.1	-2.7	0.9	-3.6	-2.3	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.6	5.9	2.3	0.6	2.1	-0.8	1.4	2.4	-0.0
Loneliness, isolation	1.2	1.7	5.6	0.1	1.8	0.6	-2.4	-0.9	1.2	0.0
Myopia	1.2	1.8	6.9	0.7	-0.9	-0.0	2.0	0.6	-0.1	2.6
Arm predicted mass (left)	1.2	6.2	11.0	-2.0	-2.3	-2.5	2.4	-3.3	-2.2	2.5
Schizophrenia vs Biploar Disorder	1.1	1.5	3.5	-1.4	-1.6	-1.9	0.6	0.6	-1.3	-0.1
Diabetes (father)	1.1	1.4	2.2	-0.5	-1.3	-0.9	1.5	-1.2	-1.3	1.1
Maternal smoking around birth	1.1	1.7	3.1	0.1	1.5	0.9	-1.8	-1.4	1.1	-1.5
Arm fat percentage (right)	1.1	4.2	11.4	-1.9	-1.3	-2.2	0.7	-3.4	-2.5	1.0
Depression (self-reported)	1.1	1.3	4.5	-1.1	-0.4	0.1	0.7	-2.1	-0.8	1.4
Arm fat-free mass (right)	1.1	5.9	7.7	-1.6	-2.4	-2.6	2.8	-2.6	-2.0	2.7
Medication: Seretide 50 evohaler	1.1	1.3	2.8	1.7	0.9	1.1	-0.5	1.6	0.6	-0.9
Arm predicted mass (right)	1.1	5.6	7.1	-1.7	-2.4	-2.5	2.6	-2.7	-1.9	2.5
Had major operations	1.1	1.3	3.1	1.0	0.9	1.0	-0.6	1.8	0.3	-1.8
Age at last live birth	1.1	1.6	6.5	-0.4	0.6	-0.3	-0.7	-2.5	-0.4	1.9
Number of operations (self-reported)	1.1	1.7	8.1	0.8	0.3	1.6	0.3	2.8	0.1	-0.6
Neuroticism (Nagel 2018)	1.0	2.4	5.1	-2.3	-1.5	-1.7	1.0	0.3	-2.0	1.1
Diabetes (mother)	1.0	1.2	4.6	-0.2	-0.8	-0.7	1.1	2.2	-0.9	-0.9
Hair/balding pattern: Pattern 4	1.0	2.3	4.1	-1.7	-1.3	-1.1	1.1	-2.0	-1.5	1.7
Eye problems/disorders: None of the above	1.0	1.1	2.2	-1.2	-0.6	-1.5	0.3	-0.8	-1.2	1.2
Neck or shoulder pain in last month	1.0	1.5	4.8	-1.3	-0.9	-1.0	0.8	2.2	-1.1	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	4.0	0.5	1.7	0.8	-2.0	-0.2	0.9	-0.5
Arm fat percentage (left)	1.0	4.2	10.4	-1.9	-1.4	-2.4	0.7	-3.2	-2.4	1.1
Leg fat mass (left)	1.0	3.9	12.3	-1.7	-0.8	-2.5	0.5	-3.5	-1.9	0.9
Body Mass Index (BMI) (2010)	0.9	1.3	5.6	-0.8	-0.3	-1.3	-0.4	-2.4	-0.8	-0.3
Ulcerative Colitis	0.9	1.2	3.5	-0.1	1.1	0.5	-1.5	-1.0	0.6	-1.9
Hypothyroidism (self reported)	0.9	2.0	5.6	1.3	1.3	1.6	-1.1	-0.8	2.4	0.8
Vitamin and mineral supplements	0.9	1.2	2.0	1.3	1.4	1.4	-1.3	0.5	0.7	-0.6
Medication: Atenolol	0.9	1.1	3.3	-0.7	-0.9	-0.8	0.2	-1.8	-1.2	1.0
Mouth/teeth dental problems	0.9	1.3	3.4	1.5	0.6	1.3	-0.5	1.8	0.9	-0.7
Alcohol intake versus 10 years previously	0.9	1.3	3.6	0.5	1.5	-0.2	-1.9	0.7	1.1	-1.1
Worrier / anxious feelings	0.9	1.6	3.1	-1.7	-1.5	-0.8	0.9	0.4	-1.7	1.3
Shortness of breath walking on level ground	0.9	1.0	2.7	1.1	1.3	1.6	-0.8	0.3	0.7	-0.7
Whole body fat mass	0.9	3.9	12.0	-1.8	-0.9	-2.4	0.4	-3.5	-2.1	1.0
Ever smoked	0.9	1.5	3.7	1.3	1.7	0.8	-1.9	-0.7	0.9	-0.3
Risk taking	0.9	1.4	3.5	1.3	0.8	0.7	-0.6	1.9	0.6	-1.6
Vascular/heart problems diagnosed by doctor	0.9	2.4	7.7	1.9	0.1	1.6	0.9	2.8	1.3	0.6
Ulcerative Colitis (UC)	0.8	1.5	3.1	0.8	1.1	1.5	-1.6	0.1	0.8	-1.8
Neuroticism	0.8	1.8	3.5	-1.9	-1.3	-0.7	0.9	1.2	-1.7	1.4
High blood pressure	0.8	2.2	8.9	-1.7	-0.1	-1.5	-0.7	-3.0	-1.1	-0.3
Trunk fat mass	0.8	3.2	9.4	-1.7	-0.7	-2.2	0.1	-3.1	-2.1	0.9
Financial difficulties in last 2 years	0.8	1.1	2.1	1.5	1.3	0.8	-0.4	0.9	1.3	-0.8
Length of working week for main job	0.8	0.9	3.0	0.3	0.6	0.2	-0.8	1.7	0.4	-1.3
Loud music exposure frequency	0.8	0.9	2.0	-1.1	0.4	-0.9	-1.4	-0.3	-0.6	-1.2
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.5	-1.4	-0.8	-0.9	0.6	0.2	-1.6	0.1
Number of children fathered	0.8	0.9	2.5	-0.9	-0.4	-0.7	-0.3	1.3	-0.8	-1.6
Emphysema/chronic bronchitis	0.8	0.9	2.0	0.6	1.4	1.0	-1.3	-0.9	0.4	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.8	1.0	0.6	1.1	-0.1	1.7	1.0	0.6
Commuting to job workplace: Walk	0.8	0.8	1.8	0.6	1.1	0.6	-1.1	-1.0	1.3	-0.1
Mother’s age at death	0.8	1.1	2.6	-0.4	-1.2	-0.4	1.6	1.1	-1.3	0.1
Medication: Blood pressure	0.8	1.5	3.5	-1.2	-1.5	-1.5	0.9	-0.3	-1.9	0.3
Medication: Lisinopril	0.8	1.0	2.8	-1.6	-0.6	-1.7	-0.1	-0.2	-1.0	-0.8
Depression (Nagel 2018)	0.7	1.0	2.0	-1.4	0.0	-1.3	-0.0	-1.4	-1.1	0.5
Alzheimer’s Disease (in mother)	0.7	0.8	2.1	-1.4	-0.4	-0.8	-0.5	-1.3	-1.0	0.0
Major Depression (MDD)	0.7	0.9	1.3	-1.1	-1.0	-0.5	1.1	0.9	-0.9	0.9
Coronary Artery Disease (CAD)	0.7	0.9	1.8	-0.7	-1.4	-0.8	1.2	0.2	-1.3	0.2
HbA1C	0.7	0.7	1.5	0.4	0.1	0.5	1.2	1.1	1.2	0.7
Cardiovascular Disease	0.7	2.2	9.0	-1.8	-0.2	-1.0	-0.6	-3.0	-1.1	0.0
Ever had hysterectomy (womb removed)	0.7	0.8	1.3	0.8	1.0	1.1	-0.4	0.9	0.4	-1.1
Number of incorrect matches in round	0.7	1.1	2.2	1.0	1.3	1.0	-1.1	0.9	1.5	0.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	7.6	1.7	0.9	2.2	-0.7	-1.0	2.8	-0.2
Leg fat percentage (right)	0.7	2.4	7.5	-1.5	-0.0	-2.1	-0.5	-2.7	-1.5	-0.1
Qualifications: College or University degree	0.7	2.1	6.0	0.4	-1.5	0.4	2.4	0.2	-0.5	2.4
Mood swings	0.7	1.2	4.2	-2.1	-1.2	-1.0	0.1	0.7	-1.1	-0.1
Illnesses of father: None of the above (group 1)	0.7	0.9	3.2	0.5	0.3	0.1	-0.5	1.8	0.8	-1.3
Eye problems/disorders: Glaucoma	0.7	0.9	2.0	1.2	0.3	1.3	0.2	1.0	1.4	0.1
Medication: Atorvastatin	0.7	0.9	2.4	-1.6	0.0	-1.1	-0.6	-0.4	-1.2	-0.7
Age started oral contraceptive pill	0.7	0.8	1.8	1.0	1.4	0.9	-0.9	-1.0	0.5	-0.4
Schizophrenia (2018)	0.6	1.2	3.6	-1.9	-0.5	-1.1	-0.7	-0.6	-1.4	-0.3
Age at First Birth	0.6	0.9	1.7	0.8	-0.6	0.9	1.1	1.3	-0.2	1.3
Blood Red Count	0.6	6.1	10.9	2.4	3.3	2.3	-3.0	0.1	2.6	-2.2
Blood White Count	0.6	4.1	6.8	2.0	2.4	1.8	-2.6	1.6	1.9	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.9	-0.4	1.1	-0.2	-1.4	-1.3	0.3	-0.2
Relative age voice broke	0.6	1.0	2.0	-1.3	-1.1	-1.1	0.8	0.2	-1.4	-0.3
Nervous feelings	0.6	1.0	2.1	-1.3	-1.3	0.1	0.8	-1.0	-0.3	1.4
Hair/balding pattern: Pattern 2	0.6	0.8	2.0	1.0	1.1	0.8	-0.2	1.4	0.9	-0.2
Medication: Ramipril	0.6	0.8	1.9	0.1	-1.0	0.2	1.4	0.6	-1.1	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.1	6.9	1.8	0.6	1.8	-0.2	-0.8	2.6	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.4	0.4	0.5	1.5	-1.1	1.5	0.3	-0.0
Birth weight of first child	0.6	1.0	1.7	-0.5	-1.0	-1.3	0.7	-1.0	-1.1	1.3
Ever highly irritable/argumentative for 2 days	0.6	0.8	2.2	-1.1	0.4	-0.6	-0.7	-0.0	-1.1	-1.5
Wheeze or whistling in the chest in last year	0.6	1.1	2.3	0.5	1.5	1.1	-1.5	0.3	0.4	-1.2
Pulse wave peak to peak time	0.6	0.7	1.8	0.1	-0.7	0.4	1.3	0.6	0.8	1.1
Medication: Blood pressure	0.6	1.1	3.8	-0.5	1.2	-0.1	-1.4	-1.9	0.1	-0.1
Medication: Ibuprofen	0.6	0.7	1.6	-0.9	-0.6	-1.1	1.3	0.9	-0.0	-0.1
Family relationship satisfaction	0.6	0.7	1.6	0.2	0.7	0.2	-1.3	-0.8	1.2	-0.8
Hypertension (Self-reported)	0.6	1.7	7.2	-1.3	0.1	-1.2	-0.9	-2.7	-0.9	-0.3
Leg fat percentage (left)	0.6	2.2	7.1	-1.4	0.4	-2.0	-1.0	-2.7	-1.1	-0.4
Irritability	0.6	1.0	3.5	-1.9	-0.4	-1.6	-0.4	0.1	-0.7	-0.4
Alzheimer’s Disease (including proxy)	0.5	0.8	3.0	-1.7	-0.2	-0.9	-0.8	-0.6	-0.6	-0.4
LDL Cholesterol	0.5	0.8	1.6	0.5	1.3	1.0	-1.1	0.4	1.3	0.1
Systolic Blood Pressure	0.5	2.5	5.7	1.4	1.3	2.4	-1.2	-0.6	1.8	-1.8
Lung FEV1/FVC ratio	0.5	2.6	4.8	1.7	2.0	1.1	-2.1	-0.1	2.2	-0.9
Pack years adult smoking proportion	0.5	0.7	2.6	-1.2	0.0	-1.6	0.0	0.4	0.0	0.9
Townsend deprivation index at recruitment	0.5	0.6	1.4	0.9	1.2	-0.1	-0.5	-0.9	0.9	-0.7
Qualifications: None of the above	0.5	1.0	2.3	-0.1	1.1	-0.3	-1.5	-1.1	0.2	-1.5
Illnesses of siblings	0.5	0.7	2.0	0.4	1.0	0.9	-1.4	-0.4	0.4	-0.6
Pulse rate	0.5	0.9	1.7	1.3	1.3	0.8	-0.7	-0.4	0.5	-1.2
Medication: Lansoprazole	0.5	0.5	1.1	0.5	1.0	1.0	-1.1	0.2	0.5	0.1
Lung cancer (father)	0.5	0.6	1.4	0.8	0.7	1.1	-0.4	-0.1	0.6	-1.2
Pulse wave Arterial Stiffness index	0.5	0.6	1.7	-0.1	0.5	-0.4	-1.3	-0.7	-0.9	-0.9
Pulse wave reflection index	0.5	0.6	1.3	-1.1	-0.8	-0.9	0.4	0.5	-0.8	0.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.0	0.7	1.2	1.0	-0.8	-0.2	1.4	1.1
Medication: Amlodipine	0.5	0.7	1.7	-0.7	-1.3	-0.5	0.8	0.2	-1.2	0.8
Exposure to tobacco smoke outside home	0.5	0.7	2.0	0.4	1.4	-0.5	-1.4	-0.0	0.1	-0.8
Medication for pain relief, constipation, heartburn	0.5	0.9	4.8	-0.4	0.1	-0.6	-0.2	-2.2	-0.9	-0.6
Alcohol intake frequency.	0.5	1.1	2.1	-1.3	-0.8	-1.4	0.9	-1.4	-0.4	0.6
Number of full sisters	0.5	0.6	3.3	-0.2	0.5	0.3	-0.7	-1.8	0.5	-0.2
Knee pain experienced in last month	0.5	0.7	1.3	-0.5	-1.1	-0.5	1.1	0.9	-1.1	0.2
Friendships satisfaction	0.5	0.6	3.0	-0.4	0.0	-0.2	-0.6	-1.7	0.5	-0.5
Qualifications: nursing, teaching	0.5	0.7	3.1	0.6	0.2	1.0	0.4	0.5	0.2	1.8
Medication: Gliclazide	0.5	0.5	0.9	-0.7	-1.0	-0.3	0.7	0.7	-0.9	0.7
Wears glasses or contact lenses	0.5	0.5	2.3	0.7	0.6	0.7	0.2	1.5	0.2	0.0
Medication: Bendroflumethiazide	0.5	0.8	1.9	-0.3	-0.5	-0.6	0.9	-1.4	-0.8	1.1
Alcohol drinker status: Previous	0.5	0.6	1.5	0.5	1.0	0.8	-0.7	-0.3	1.2	-0.4
Pack years of smoking	0.5	0.8	2.8	-1.3	-0.1	-1.7	0.1	0.2	-0.1	0.9
Depressed Affect (Nagel 2018)	0.4	0.8	2.6	-1.6	-0.1	-1.0	-0.6	0.3	-1.1	0.1
Worry (Nagel 2018)	0.4	0.9	1.8	-0.8	-1.4	0.1	1.1	0.8	-1.2	0.8
Ovarian Cancer	0.4	0.5	1.3	-1.1	-0.8	-1.1	0.5	0.2	-0.3	0.5
Prostate Cancer	0.4	0.6	2.0	0.1	0.9	0.4	-0.8	-1.4	0.4	-0.4
Heel T-Score	0.4	3.0	7.7	0.0	-1.6	-0.6	2.8	-0.3	-1.5	2.8
Waist Hip Ratio (WHR)	0.4	1.6	3.2	1.7	1.3	1.8	-0.6	0.5	1.6	-0.7
Tanning	0.4	5.2	8.5	-2.9	-2.6	-2.7	1.2	0.7	-2.8	2.0
Hand grip strength (left)	0.4	1.1	5.3	-0.3	0.0	0.0	0.0	-1.1	0.9	2.3
Medication: Co-codamol	0.4	0.5	1.6	1.1	0.2	1.2	0.5	0.7	0.2	0.0
Trunk fat percentage	0.4	1.6	5.5	-0.8	0.6	-1.1	-1.3	-2.4	-1.2	-0.4
Fed-up feelings	0.4	0.7	2.2	-1.1	0.5	-0.7	-1.5	-0.3	-0.8	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	3.2	0.5	-1.1	-0.3	1.8	0.6	-0.3	0.7
Medication: Levothyroxine sodium	0.4	0.6	1.4	0.1	0.7	0.7	-0.6	-1.0	0.7	1.2
Past tobacco smoking	0.4	0.7	1.8	-0.9	-1.2	-0.8	1.3	0.0	-0.3	0.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.0	0.7	0.8	0.7	-1.0	0.3	0.3	-0.4
Neuroticism score	0.4	0.8	3.4	-1.8	-0.5	-0.4	-0.3	-0.2	-1.0	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	-0.6	-0.3	-0.6	0.8	1.2	0.6	-0.1
Medication: Cholesterol lowering	0.4	0.7	2.9	-0.9	0.2	-0.4	-0.4	-1.7	-0.7	0.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.7	0.9	-0.3	0.7	0.5	1.6	0.5	0.0
Birth weight	0.4	0.8	1.4	-0.7	-0.6	-1.0	1.2	-1.1	-0.7	0.7
Forced vital capacity (FVC), Best measure	0.4	1.3	4.2	1.3	-0.1	1.5	0.1	-0.6	2.1	0.8
Body fat percentage	0.4	1.6	6.3	-0.9	0.4	-1.3	-1.0	-2.5	-1.2	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.2	0.6	0.7	1.1	-0.9	0.1	0.7	-0.3
Medication: Allopurinol	0.4	0.5	1.0	-0.9	-0.8	-1.0	-0.1	-0.2	-1.0	0.5
Pulse rate, automated reading	0.4	1.2	2.5	-0.5	1.6	-0.5	-1.2	-1.5	-0.2	-1.2
Comparative height size at age 10	0.4	2.4	13.0	0.3	-1.1	-0.5	1.6	-0.4	0.2	3.6
Suffer from ‘nerves’	0.4	0.6	1.3	-0.4	-1.0	-0.0	1.1	0.4	-0.6	1.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.2	-0.6	0.2	0.2	-0.9	-0.2	1.5	-0.3
Smoking status: Previous	0.4	0.5	1.6	1.0	0.5	1.3	-0.1	0.8	0.3	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.8	0.2	0.0	0.6	0.2	-1.3	0.6	1.0
Commuting to job workplace: Public transport	0.4	0.5	2.3	-0.0	0.6	-0.2	-0.8	-1.5	0.1	0.0
Illnesses of father: High blood pressure	0.4	0.5	1.5	-1.2	-0.3	-0.7	-0.3	-1.1	0.0	0.5
Unable to work because of sickness or disability	0.4	0.5	1.2	-0.1	0.4	0.1	-1.1	1.1	-0.6	-0.7
Bipolar Disorder or Schizophrenia	0.3	0.7	2.3	-1.5	0.2	-0.7	-0.6	-0.7	-0.9	-0.1
Alzheimer’s Disease (in father)	0.3	0.4	0.8	-0.8	0.3	-0.9	-0.2	0.8	-0.5	-0.4
Bipolar Disorder (2011)	0.3	0.3	1.1	0.0	0.3	0.5	0.5	-1.1	-0.1	0.3
HDL Cholesterol	0.3	0.5	1.1	0.8	-0.1	0.8	-0.7	1.1	-0.7	-0.3
Lupus	0.3	0.4	0.9	-0.3	0.5	0.4	-0.8	1.0	-0.3	-0.8
Schizophrenia (2014)	0.3	0.6	1.7	-1.0	0.4	-0.2	-1.0	-0.3	-0.5	-1.3
Triglycerides	0.3	0.4	1.5	-0.7	0.6	-0.3	-0.6	-1.2	0.1	0.3
Blood Platelet Count	0.3	3.4	8.5	2.1	1.6	1.5	-1.1	2.9	1.7	-1.3
Lung FVC	0.3	1.6	3.6	1.9	0.3	1.8	0.2	-0.8	1.9	0.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	-0.8	0.6	-0.3	-0.4	-1.0	-0.3	0.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.7	-0.5	-0.5	-0.5	0.6	-0.8	-0.8	0.1
Serious illness, injury or assault to yourself	0.3	0.4	2.2	0.2	0.1	0.4	0.1	1.5	-0.5	-0.1
Forced vital capacity (FVC)	0.3	1.1	3.7	1.0	0.2	1.5	-0.2	-0.6	1.9	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.4	-0.5	0.1	-0.3	0.4	-0.6	-0.1	1.5
Breastfed as a baby	0.3	0.4	0.8	-0.9	0.0	-0.9	-0.6	0.3	-0.8	0.1
Peak expiratory flow (PEF)	0.3	0.6	1.1	0.7	-0.1	1.1	1.0	-0.2	0.9	0.8
Gout (self-reported)	0.3	0.4	0.9	-0.9	-0.8	-0.5	-0.3	-0.2	-0.6	0.7
High blood pressure (siblings)	0.3	0.4	1.6	0.1	-0.3	-0.3	0.5	0.6	0.4	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.9	0.7	0.8	0.9	-0.2	-0.1	0.3	-0.8
Health satisfaction	0.3	0.4	1.3	-0.9	-0.4	-0.5	0.0	-0.2	-0.2	1.1
Migraine (self-reported)	0.3	0.4	0.9	-0.3	-0.6	-0.2	1.0	-0.6	-0.3	0.9
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.9	0.0	-0.5	-0.2	0.2	0.9	-0.9	-0.9
Medication: Aspirin	0.3	0.4	0.9	0.7	-0.0	0.4	-0.3	0.7	0.6	1.0
Illnesses of siblings: Diabetes	0.3	0.3	0.8	-0.9	-0.2	-0.5	0.4	-0.6	-0.5	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.7	-0.2	-0.6	-0.1	1.0	-0.7	-0.3	1.3
Breast cancer (self-reported)	0.3	0.4	1.4	-0.5	0.2	-0.6	0.1	1.2	-0.7	0.3
Medication: Aspirin	0.3	0.3	0.8	0.6	-0.3	0.3	-0.2	0.9	0.5	0.9
Number of self-reported non-cancer illnesses	0.3	0.5	1.4	-0.8	-0.8	-0.0	0.6	-0.1	-1.2	0.5
Financial situation satisfaction	0.3	0.4	1.4	-0.4	0.2	-0.3	-0.5	0.8	0.2	-1.2
Ever depressed for a whole week	0.3	0.4	1.2	-0.1	0.6	-0.4	-1.1	0.3	-0.3	-1.0
Cholesterol lowering medication	0.3	0.4	1.3	-0.1	-0.4	-0.3	0.9	0.7	0.1	1.2
Fasting Glucose	0.2	0.3	0.7	-0.6	-0.1	-0.7	0.5	0.1	-0.8	-0.4
Sensitivity / hurt feelings	0.2	0.3	1.2	-1.1	-0.3	-0.5	0.4	-0.1	-0.4	0.7
Hearing difficulty/problems: Yes	0.2	0.3	0.7	-0.7	0.5	0.3	-0.7	0.1	0.2	-0.8
Relative age of first facial hair	0.2	0.4	1.0	-0.7	-0.6	-1.0	0.5	-0.4	-0.7	-0.1
Systolic blood pressure, automated reading	0.2	0.7	1.9	1.3	0.4	1.4	-0.0	-0.3	0.7	-0.8
Hand grip strength (right)	0.2	0.4	2.1	-0.5	-0.1	-0.6	0.0	-0.6	0.2	1.4
Sitting height	0.2	1.2	3.3	-1.1	-0.9	-1.1	0.7	-1.0	-0.1	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.3	-1.1	0.2	-0.4	-0.3	-0.7	-0.1	0.1
Allergy	0.2	0.5	1.6	-0.5	-1.1	-1.3	0.6	-0.1	-0.5	-0.1
Medication: Simvastatin	0.2	0.3	1.0	-0.1	0.0	-0.3	-0.0	-0.9	0.2	1.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	0.5	0.6	0.3	-0.4	-0.1	0.6	-0.3
Medication: Paracetamol	0.2	0.4	2.1	-0.2	-0.4	0.2	0.4	1.4	-0.0	0.6
Age at first live birth	0.2	0.4	1.2	-0.2	-0.2	0.0	0.2	-1.0	-0.6	1.1
Chest pain or discomfort	0.2	0.3	0.9	-0.1	0.5	0.1	-0.7	0.9	0.4	-0.3
Leg pain on walking	0.2	0.2	0.7	-0.5	-0.7	-0.2	-0.0	0.8	-0.3	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.7	0.5	-0.0	0.2	-0.7	0.2	-0.0	-0.8
Average weekly red wine intake	0.2	0.4	1.1	-0.4	-0.6	-0.1	0.9	-0.3	-0.3	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.2	0.4	-0.1	-0.8	0.4	0.4	-0.2
Asthma (self-reported)	0.2	0.4	1.1	-0.9	-0.4	-0.8	0.1	0.4	-1.1	0.5
Miserableness	0.2	0.3	1.1	-1.0	0.3	-0.2	-0.8	0.6	-0.3	-0.1
High cholesterol (Self-reported)	0.2	0.3	1.3	-0.1	0.3	0.1	-0.1	-1.1	0.3	0.8
Medication: Paracetamol	0.2	0.3	0.7	-0.8	-0.5	-0.6	0.1	0.2	-0.5	0.6
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.9	0.4	0.5	0.3	-0.2	0.9	0.4	-0.5
Fractured/broken bones in last 5 years	0.2	0.3	1.1	-0.3	0.8	-0.4	-1.0	0.3	0.2	0.2
Bipolar Disorder (2018)	0.1	0.2	1.1	-0.1	1.0	0.3	-0.2	-0.4	0.2	0.3
Respiratory disease	0.1	0.3	0.5	-0.5	0.3	-0.6	-0.7	0.6	-0.7	0.2
Number of treatments/medications taken	0.1	0.1	0.2	-0.1	0.2	0.5	-0.1	0.1	0.3	-0.5
Angina	0.1	0.1	0.3	-0.6	-0.2	-0.2	-0.4	-0.1	-0.4	0.3
Multivitamins +/- minerals	0.1	0.1	0.3	0.1	0.3	-0.1	-0.0	-0.6	0.5	-0.5
High blood pressure (mother)	0.1	0.1	0.3	0.0	-0.2	0.1	0.1	-0.5	0.5	0.4
Hearing difficulty/problems with background noise	0.1	0.2	1.0	-1.0	-0.2	-0.4	-0.3	0.6	0.0	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.8	0.5	-0.4	-0.1	0.9	0.6	0.2	0.2
Heart attack	0.1	0.1	0.4	-0.1	0.3	-0.1	-0.6	0.4	-0.3	-0.5
Number of live births	0.1	0.1	0.4	0.2	0.2	0.5	0.4	-0.0	0.6	0.0
Asthma	0.1	0.2	0.4	-0.4	0.0	-0.3	-0.2	0.6	-0.6	0.2
Standing height	0.1	1.0	5.1	-0.2	-0.7	-0.4	0.7	-0.6	-0.1	2.3
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.8	0.1	0.5	0.0	-0.9	0.1	-0.3	-0.2
Number of full brothers	0.1	0.2	0.6	0.0	-0.2	0.5	0.7	0.1	-0.0	-0.5
Angina (self-reported)	0.1	0.1	0.3	-0.4	-0.1	-0.1	-0.5	-0.2	-0.3	0.2
Medication for cholesterol	0.1	0.2	0.4	0.5	0.4	0.2	-0.2	-0.5	0.5	0.6
Basal cell carcinoma (self-reported)	0.1	0.2	0.5	-0.7	-0.2	-0.3	-0.2	0.7	0.1	0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.5	-0.2	0.5	-0.1	-0.7	0.2	-0.3	-0.6
Blood Eosinophil Count	0.0	0.2	0.8	0.6	0.5	0.1	-0.2	-0.9	0.3	0.3
Height	0.0	0.5	2.9	0.0	0.0	-0.2	-0.2	0.7	0.1	1.7
Hair Pigment	0.0	1.4	3.6	-1.5	-0.1	-1.9	1.2	-0.4	-1.6	0.0

Hub : Genes

GNAO1

Models

Trait associations