Hub : Genes

GNB4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.062 0.0290 8.6e-03 0.028 0.019 0.034 0.023 0.034 2.0e-04 0.0018 5.3e-05 0.00063 4.3e-05
2 GTEx Artery Aorta 0.163 0.0640 1.8e-03 0.022 NA 0.065 NA 0.048 2.2e-02 NA 1.8e-04 NA 1.2e-03
3 GTEx Esophagus Mucosa 0.116 0.0490 3.6e-03 0.001 NA 0.030 NA 0.011 2.8e-01 NA 4.1e-03 NA 5.4e-02
4 GTEx Heart Atrial Appendage 0.560 0.0680 2.3e-11 0.453 NA 0.330 NA 0.423 2.0e-22 NA 1.7e-15 NA 1.3e-20
5 GTEx Heart Left Ventricle 0.451 0.0733 6.1e-10 0.284 NA 0.328 NA 0.347 1.9e-15 NA 4.7e-18 NA 3.0e-19
6 TCGA Lung Adenocarcinoma 0.062 0.0346 1.3e-03 0.011 0.018 0.016 NA 0.013 1.6e-02 0.0032 4.9e-03 NA 1.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.5 2.4 5.7 -0.2 -2.4 -1.6 1.8 1.6 -0.4
Bipolar Disorder or Schizophrenia 0.4 0.9 2.3 0.5 -1.5 -1.4 0.8 0.7 0.2
Depressed Affect (Nagel 2018) 1.1 2.4 3.8 -1.6 -2.0 -1.5 1.6 1.6 -0.4
Depression (Nagel 2018) 1.1 1.7 6.9 -2.6 0.9 -0.6 -0.3 -0.3 -1.3
Intelligence (Savage-Jansen 2018) 0.1 0.4 0.8 -0.9 0.7 -0.2 -0.2 -0.1 -0.9
Neuroticism (Nagel 2018) 0.4 0.8 2.6 0.0 -1.6 -1.0 0.7 0.7 0.7
Schizophrenia (2018) 0.1 0.3 0.6 0.8 -0.0 -0.5 -0.4 -0.4 0.6
Schizophrenia vs Biploar Disorder 0.4 0.6 1.4 0.2 -0.4 0.6 -1.2 -1.2 0.1
Worry (Nagel 2018) 0.5 1.1 3.5 1.2 -1.2 -0.3 0.2 0.3 1.9
Alzheimer’s Disease (in mother) 0.7 0.8 2.6 0.4 -1.6 -0.9 0.7 0.7 0.4
Alzheimer’s Disease (in father) 0.2 0.2 0.4 -0.1 0.4 0.6 -0.5 -0.5 0.2
Alzheimer’s Disease (including proxy) 0.3 0.5 0.7 0.8 -0.6 -0.9 0.4 0.4 0.8
Crohns Disease (2017) 0.5 1.1 4.0 0.2 2.0 -0.6 0.7 0.7 1.0
Irritable Bowel Disease (IBD) 0.3 0.7 3.1 -0.9 1.8 -0.0 -0.4 -0.5 0.0
Ulcerative Colitis (UC) 0.3 0.6 1.5 -1.2 0.7 0.6 -0.7 -0.8 -0.4
Major Depression (MDD) 1.1 1.3 2.2 -1.4 -0.6 0.3 1.5 1.5 -1.1
Reaction Time 0.9 1.7 3.3 -0.9 -1.8 -0.5 1.8 1.7 0.3
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.3 -0.6 0.5 0.2 -0.5 -0.3 -0.2
Breast Cancer 1.6 3.9 8.0 2.4 2.8 0.7 -2.1 -2.1 0.7
Ovarian Cancer 0.2 0.3 0.9 0.7 -0.9 -0.5 -0.2 -0.3 -0.2
Prostate Cancer 1.6 2.2 5.0 -2.2 2.2 -0.2 1.2 1.3 -0.6
Age at First Birth 0.1 0.2 0.4 0.7 -0.5 0.2 -0.4 -0.5 0.1
Bipolar Disorder (2011) 1.5 1.4 3.2 0.4 -0.6 0.4 1.8 1.7 1.3
Body Mass Index (BMI) (2010) 0.7 1.0 3.2 -0.2 0.6 1.8 -0.6 -0.5 1.3
Coronary Artery Disease (CAD) 1.5 1.8 3.2 1.2 -1.8 -0.2 1.8 1.7 0.6
Crohns Disease (2012) 1.0 1.6 3.0 -1.0 1.5 1.6 0.7 0.6 1.7
Mean Putamen Volume 0.5 0.5 2.2 1.0 -0.1 0.1 -0.2 -0.2 1.5
Fasting Glucose 1.4 1.7 3.8 2.0 -1.8 -1.4 0.2 0.4 -0.8
HbA1C 0.9 1.0 2.7 1.3 -1.6 -1.1 0.2 0.2 0.2
HDL Cholesterol 0.6 0.9 1.9 0.1 -0.4 -0.7 -1.3 -1.4 -1.1
LDL Cholesterol 0.4 0.7 1.6 0.5 0.9 0.1 -1.1 -1.3 -0.4
Lupus 0.8 1.1 3.6 0.1 -0.5 -1.9 0.7 0.7 -1.4
Neuroticism (2016) 0.5 0.7 1.6 1.2 1.1 -0.7 -0.6 -0.6 -0.2
Primary Biliary Cirrhosis 0.7 1.0 2.4 1.2 -1.1 -1.5 0.5 0.5 -0.7
Rheumatoid Arthritis 0.2 0.2 0.5 0.2 0.7 -0.3 0.5 0.3 0.5
Schizophrenia (2014) 0.1 0.2 0.8 -0.6 -0.3 -0.9 -0.1 -0.1 0.5
Triglycerides 0.1 0.2 0.4 -0.3 0.7 0.2 -0.6 -0.6 0.0
Type 2 Diabetes (T2D) (2012) 1.0 1.2 2.1 -0.7 -0.8 -0.4 1.3 1.4 1.4
Ulcerative Colitis 0.3 0.5 2.4 -1.6 0.2 0.6 0.3 0.2 -0.4
Blood Eosinophil Count 0.2 1.8 5.4 -1.1 1.4 -1.1 0.8 0.8 -2.3
Blood Platelet Count 0.3 3.4 6.8 -1.3 2.6 -1.3 -1.8 -1.5 -2.2
Blood Red Count 0.2 1.6 4.5 -0.1 1.6 -2.1 0.7 0.9 -1.1
Blood White Count 0.4 2.7 8.5 -1.9 1.9 -0.5 -0.2 -0.1 -2.9
Heel T-Score 0.1 0.5 1.5 1.2 0.7 -0.2 -0.4 -0.4 0.7
BMI 1.0 6.0 12.0 -2.4 -1.1 -1.7 3.4 3.5 -1.6
Height 0.1 2.2 5.7 -0.9 -1.4 -2.4 0.7 0.7 -2.0
Waist Hip Ratio (WHR) 0.4 1.9 5.2 -2.3 -0.0 -1.0 0.7 0.7 -2.0
Systolic Blood Pressure 0.5 2.4 5.2 1.0 1.5 0.9 -2.3 -2.2 -0.3
Smoking Status 0.6 1.4 6.8 0.8 2.6 -0.7 -0.1 -0.0 -0.6
Allergy or Eczema 1.0 2.6 4.5 1.8 0.9 0.6 -2.1 -2.1 1.6
Cardiovascular Disease 0.7 2.2 5.3 0.9 0.9 1.1 -2.2 -2.3 0.1
Hypothyroidism (self reported) 0.3 0.8 1.3 0.2 -1.0 -0.1 1.1 1.1 -1.0
Respiratory disease 0.2 0.5 1.8 -0.1 1.3 0.2 -0.9 -0.7 0.2
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.6 0.0 -0.3 0.3 1.3 1.2 0.6
Lung FEV1/FVC ratio 0.2 0.9 2.1 -1.4 -0.1 0.4 1.1 1.1 0.7
Lung FVC 0.2 0.8 2.1 -0.4 -1.4 -0.2 1.2 1.1 0.3
Neuroticism 0.1 0.2 0.7 -0.3 -0.8 -0.3 -0.2 -0.1 0.7
Chronotype (morning person) 1.3 3.0 8.4 0.1 -1.6 -2.9 1.1 1.0 -2.2
Hair Pigment 0.1 2.4 8.6 1.2 0.2 1.0 1.4 1.2 2.9
Tanning 0.1 1.5 2.8 0.7 1.3 -1.0 -1.7 -1.6 -0.7
Hand grip strength (left) 0.6 1.5 3.9 1.5 -0.7 1.6 0.0 0.0 2.0
Number of treatments/medications taken 0.8 1.4 3.5 -0.8 -0.6 -0.8 1.9 1.9 -0.2
Average weekly spirits intake 1.4 1.8 4.9 2.2 -0.8 1.1 -0.4 -0.3 1.9
Sensitivity / hurt feelings 0.3 0.5 1.1 -0.1 -1.0 -0.0 -0.9 -1.0 0.2
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.9 -1.7 -1.1 -1.1 0.3 0.2 -0.8
Hearing difficulty/problems: Yes 0.3 0.5 1.6 0.4 0.1 1.0 -0.2 -0.1 1.3
Relative age of first facial hair 0.4 0.7 1.8 1.3 1.4 0.4 -0.1 -0.1 0.9
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.8 0.7 0.3 -0.9 0.8 0.9 -0.5
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.0 -0.6 -1.0 -0.7 0.9 0.9 -0.5
Ever had hysterectomy (womb removed) 1.1 1.2 2.4 -0.7 -0.3 -0.9 1.5 1.6 -1.0
Systolic blood pressure, automated reading 0.5 1.4 1.9 1.3 0.3 -1.4 -1.4 -1.3 -1.1
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 3.2 0.4 -0.8 -1.8 0.8 0.9 -1.1
Angina 1.7 2.2 5.0 -0.0 -1.2 -1.7 1.5 1.4 -2.2
Medication for hormone replacement therapy 0.9 1.0 2.0 -1.0 1.2 1.4 -0.8 -0.9 0.1
Vitamin and mineral supplements 0.9 1.2 2.0 -0.6 -1.3 -1.0 1.3 1.4 -0.2
Supplements: Zinc 0.8 0.9 3.0 1.7 -0.2 0.3 0.6 0.8 1.1
Medication: Co-codamol 0.2 0.2 0.8 -0.3 -0.2 -0.0 0.3 0.3 -0.9
Medication: Metformin 0.8 1.1 2.2 -0.4 -1.4 -0.2 1.5 1.5 0.5
Diabetes (father) 0.8 1.0 4.0 2.0 -1.1 -0.7 0.2 0.2 -0.7
Diabetes (mother) 2.5 3.1 4.8 0.5 -1.8 -1.6 2.2 2.1 -1.9
Severe depression (siblings) 0.2 0.3 0.5 0.3 0.6 -0.2 -0.7 -0.7 -0.3
Pack years adult smoking proportion 0.3 0.5 2.0 -0.1 -0.7 -1.4 0.2 0.2 -0.7
Impedance of leg (right) 0.4 2.1 4.6 -1.3 1.1 -0.1 -2.1 -2.1 -0.8
Leg fat-free mass (left) 0.9 4.5 9.6 -0.7 -2.2 -1.5 3.1 3.0 -0.9
Trunk fat percentage 1.6 6.5 10.7 -2.2 -1.3 -2.9 3.2 3.3 -1.9
Hand grip strength (right) 0.5 1.4 2.9 1.7 -1.5 0.4 -0.7 -0.6 1.5
Townsend deprivation index at recruitment 0.6 0.8 1.6 1.3 -0.9 -0.8 0.3 0.5 1.1
Current tobacco smoking 1.8 3.0 8.8 1.9 3.0 -0.5 -1.6 -1.6 -0.6
Average weekly fortified wine intake 0.2 0.2 0.8 0.5 -0.0 0.9 -0.4 -0.5 0.0
Maternal smoking around birth 1.2 1.7 4.0 -0.4 0.5 -1.7 -1.1 -1.3 -2.0
Fed-up feelings 0.6 1.0 3.7 -0.3 -1.9 -1.1 0.6 0.6 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 2.0 -1.4 0.9 -0.3 0.1 -0.0 -0.7
Relative age voice broke 0.6 0.9 2.2 0.7 1.5 0.3 -0.4 -0.3 1.5
Taking other prescription medications 0.2 0.4 0.8 0.9 0.2 -0.0 0.7 0.8 0.4
Age when periods started (menarche) 0.0 0.1 0.2 -0.3 0.4 -0.5 -0.3 -0.4 0.2
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.9 0.9 -0.3 -0.2 -0.3 -0.5 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.6 -0.5 0.1 -0.0 -0.7 -0.8 -0.5
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.8 -0.7 -0.0 -0.2 1.3 1.3 0.7
Qualifications: CSEs or equivalent 0.2 0.3 0.5 -0.5 0.5 0.7 -0.2 -0.3 0.7
Serious illness, injury or assault to yourself 1.1 1.4 5.2 -1.0 2.3 -0.8 0.7 0.6 -0.7
High blood pressure 0.2 0.6 1.2 0.7 0.8 0.4 -1.1 -1.1 0.2
Hayfever, allergic rhinitis or eczema 0.7 1.6 4.2 0.8 0.7 -0.0 -2.0 -2.0 0.6
Multivitamins +/- minerals 0.2 0.2 1.1 0.1 1.0 0.1 -0.3 -0.4 0.2
Stomach or abdominal pain in last month 0.4 0.5 1.2 -0.1 -0.9 -1.1 0.0 -0.1 -0.9
Supplements: Glucosamine 1.2 1.6 2.8 0.5 1.7 1.2 -1.3 -1.3 1.3
Diverticular disease/diverticulitis (self-reported) 2.2 2.6 6.2 -0.6 -2.5 -2.3 1.1 0.9 -1.3
Medication: Atenolol 0.7 0.9 2.3 0.8 -1.0 -1.5 -0.1 -0.2 -1.2
Medication: Levothyroxine sodium 0.2 0.4 0.8 0.4 0.3 0.7 0.9 0.8 0.4
Sitting height 0.0 0.3 0.7 0.9 -0.7 -0.4 0.3 0.2 0.5
Chronic bronchitis/emphysema (father) 0.7 0.8 1.4 0.6 0.8 -0.9 -1.2 -1.1 -0.6
High blood pressure (mother) 0.7 1.0 2.2 -1.0 0.0 1.5 -0.9 -0.7 1.2
Body mass index (BMI) 1.9 8.3 19.7 -1.4 -1.9 -1.6 4.4 4.4 -1.4
Impedance of leg (left) 0.5 2.5 5.3 -1.3 1.7 0.3 -2.3 -2.2 -0.4
Leg predicted mass (left) 0.9 4.5 9.4 -0.7 -2.3 -1.5 3.1 3.0 -0.9
Trunk fat mass 1.8 7.8 14.5 -2.5 -1.6 -2.6 3.7 3.8 -1.9
Waist circumference 1.7 6.4 16.1 -1.2 -1.0 -1.7 3.9 4.0 -1.2
Number of incorrect matches in round 0.2 0.3 1.1 1.0 0.2 0.2 0.0 0.0 0.8
Past tobacco smoking 1.4 2.6 6.2 -0.7 -1.1 0.0 -2.4 -2.5 -1.3
Alcohol usually taken with meals 0.4 0.7 2.5 -0.0 0.5 1.6 -0.8 -0.9 -0.0
Nervous feelings 1.2 2.2 4.9 2.2 -1.3 0.6 1.3 1.3 1.8
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 4.5 -0.1 -2.1 -0.3 0.8 0.8 -0.1
Hearing difficulty/problems with background noise 1.3 2.0 7.0 2.6 -0.5 0.6 -0.8 -0.8 1.8
Hair/balding pattern: Pattern 2 0.6 0.8 2.0 0.4 0.8 0.1 -1.2 -1.4 -0.6
Had menopause 1.7 2.1 6.1 -0.6 -1.2 -2.5 1.1 1.1 -1.6
Had other major operations 1.3 1.6 3.4 0.6 1.5 -0.1 -1.8 -1.7 -0.4
Forced vital capacity (FVC) 0.3 1.2 2.2 -0.6 -1.2 -1.1 1.4 1.5 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 2.9 -0.5 0.9 0.3 -1.7 -1.7 -0.6
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.9 0.9 -1.4 -0.4 0.3 0.3 0.5
Qualifications: None of the above 0.4 0.9 1.9 1.4 -1.3 0.3 -0.7 -0.7 0.9
Financial difficulties in last 2 years 1.3 1.8 3.8 -1.9 1.6 -1.1 0.4 0.4 -1.7
Mouth/teeth dental problems 0.4 0.6 1.8 -1.3 0.9 -0.3 -0.2 0.1 -1.0
Heart attack 1.1 1.4 3.6 0.8 -0.8 -0.5 1.9 1.8 -0.0
Allergy 0.4 0.9 2.3 -0.3 -0.8 -0.4 1.5 1.5 -0.6
Pain all over the body in last month 0.4 0.5 1.0 0.9 -0.1 -1.0 0.5 0.5 -0.7
Diabetes (self-reported) 0.8 1.2 3.1 0.5 -0.3 -0.8 1.8 1.7 0.4
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.6 0.2 -1.3 -1.2 -0.7 -0.6 -0.1
Medication: Ramipril 0.4 0.5 1.3 1.1 0.7 -0.7 0.4 0.4 -0.4
Medication: Simvastatin 0.9 1.3 2.2 -0.4 -0.5 -1.5 1.5 1.5 -0.9
Fluid intelligence score 0.2 0.4 1.0 -0.7 1.0 0.6 -0.4 -0.2 -0.6
Illnesses of siblings 0.0 0.1 0.3 -0.5 0.2 -0.1 -0.0 0.0 -0.1
Neuroticism score 0.2 0.4 1.1 -0.2 -1.0 0.2 0.2 0.2 1.1
Weight 1.7 8.6 18.6 -1.8 -2.1 -2.1 4.3 4.3 -1.6
Impedance of arm (right) 1.2 5.6 15.0 0.6 1.8 0.2 -3.9 -3.8 1.0
Arm fat percentage (right) 1.6 6.3 14.1 -1.4 -1.8 -2.0 3.7 3.8 -1.1
Trunk fat-free mass 0.9 5.2 12.3 -1.0 -2.0 -0.9 3.5 3.5 -0.7
Hip circumference 1.1 4.9 13.8 -0.8 -1.0 -1.0 3.6 3.7 -0.0
Time employed in main current job 1.0 1.1 2.6 1.2 -0.9 -0.3 0.9 1.0 1.6
Alcohol intake versus 10 years previously 0.6 0.9 1.6 0.9 1.3 0.5 -1.0 -1.0 0.6
Father’s age at death 0.1 0.1 0.4 0.0 -0.1 0.6 0.2 0.2 -0.1
Worrier / anxious feelings 0.4 0.8 2.8 0.5 -1.7 -1.3 -0.2 -0.2 0.0
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 3.4 0.6 1.6 -0.3 -1.7 -1.9 -0.5
Falls in the last year 1.6 2.1 4.3 0.3 -0.9 -1.9 1.9 2.1 -0.0
Hair/balding pattern: Pattern 3 0.4 0.6 2.2 -1.5 0.7 0.5 0.4 0.5 0.4
Number of live births 0.5 0.7 1.6 1.0 0.4 -0.4 0.7 0.8 1.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.1 -1.0 -0.6 -0.5 1.0 1.0 0.6
Pulse rate 4.4 7.5 21.5 1.8 0.4 0.2 -4.5 -4.6 -0.3
Happiness 0.6 0.7 2.1 -0.4 -1.4 -0.3 1.1 1.0 -0.1
Noisy workplace 0.4 0.5 1.3 0.9 0.4 -0.4 0.4 0.4 1.2
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.6 -1.0 -1.2 -0.0 1.2 1.2 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 3.0 1.7 -0.4 0.5 0.3 0.1 1.0
Mouth/teeth dental problems: Dentures 0.9 1.5 6.8 2.6 -1.0 -1.0 -0.2 -0.3 0.3
Asthma 0.2 0.3 0.8 -0.9 0.8 -0.4 -0.4 -0.2 -0.5
Medication: Ibuprofen (e.g. Nurofen) 1.7 2.1 5.6 -2.2 2.4 1.1 -0.7 -0.7 0.7
Medication: Cholesterol lowering 0.4 0.6 1.3 -0.5 -0.2 -0.4 1.1 1.1 -0.9
Depression (self-reported) 0.4 0.5 1.5 1.2 0.0 1.1 0.3 0.1 0.6
Medication: Lansoprazole 1.0 1.2 2.4 0.2 -0.9 -1.6 1.2 1.3 -0.7
Prospective memory result 1.1 1.4 3.2 0.3 -1.8 -1.7 0.5 0.4 -1.2
Lung cancer (father) 0.5 0.6 2.8 1.7 0.3 -0.5 -0.3 -0.3 0.3
Illnesses of mother 0.3 0.3 1.0 0.0 0.9 -0.2 0.3 0.2 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 2.9 -1.4 -1.4 -0.3 1.7 1.6 1.1
Pulse wave Arterial Stiffness index 0.6 0.7 1.1 -0.7 -0.6 -0.5 1.0 1.0 -1.0
Impedance of arm (left) 1.2 5.7 15.7 0.4 1.6 -0.3 -4.0 -3.9 0.8
Arm fat mass (right) 2.2 9.1 19.8 -1.8 -2.1 -2.4 4.4 4.5 -1.6
Trunk predicted mass 0.9 5.1 12.0 -1.0 -2.1 -0.9 3.5 3.5 -0.7
Standing height 0.1 0.7 2.2 -1.1 -0.5 -1.5 0.1 0.2 -0.8
Length of working week for main job 0.4 0.5 1.1 -0.4 -0.2 -0.3 1.0 1.1 0.7
Exposure to tobacco smoke at home 0.3 0.3 0.7 -0.2 -0.0 -0.2 -0.8 -0.8 -0.7
Breastfed as a baby 1.0 1.3 2.8 -0.3 -1.4 0.0 1.7 1.7 -0.0
Tense / ‘highly strung’ 0.4 0.6 1.4 -0.0 -0.9 -0.2 -1.1 -1.2 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.7 -1.3 -1.0 -0.3 1.0 0.9 -1.0
Hair/balding pattern: Pattern 4 0.8 1.9 5.6 2.4 0.3 0.8 0.0 0.0 2.2
Birth weight of first child 1.3 2.4 10.4 -3.2 -1.2 -0.6 0.3 0.2 -1.4
Peak expiratory flow (PEF) 0.3 0.8 2.8 0.7 0.6 0.8 0.3 0.4 1.7
Pulse wave reflection index 1.8 2.2 4.7 -0.8 -0.0 -1.5 2.1 2.2 -1.2
Ever highly irritable/argumentative for 2 days 1.8 2.1 3.4 1.8 0.9 -0.9 -1.8 -1.8 -1.1
Loud music exposure frequency 0.2 0.2 0.8 -0.9 0.1 0.2 -0.2 -0.2 0.5
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 1.7 -0.6 0.7 -1.0 1.3 1.3 -0.9
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.2 -0.3 0.4 0.4 0.1 -0.1 -0.5
Blood clot in the leg (DVT) 0.9 1.1 2.8 1.1 -1.1 1.0 0.5 0.5 1.7
Medication: Paracetamol 0.5 0.8 4.2 -2.0 -0.2 -0.2 0.3 0.4 -0.3
Headache pain in last month 0.5 0.8 4.3 -2.1 -0.5 0.3 0.3 0.2 -0.2
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 2.1 -0.0 0.5 1.3 -1.4 -1.3 1.4
Glaucoma (self-reported) 1.6 1.9 4.0 -1.6 0.6 -1.4 1.0 1.2 -2.0
Gout (self-reported) 0.6 0.8 1.7 -0.9 0.4 0.2 1.3 1.3 0.8
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 5.3 -0.2 -0.4 0.2 2.3 2.3 -0.1
Medication: Amlodipine 0.2 0.3 1.0 0.7 0.3 -1.0 -0.1 -0.2 -0.6
Medication: Ventolin 100micrograms inhaler 0.3 0.3 1.0 0.6 1.0 0.0 -0.6 -0.6 0.4
Birth weight 0.9 2.0 7.7 -2.8 -0.6 -1.2 0.3 0.3 -1.5
Chronic bronchitis/emphysema (mother) 0.5 0.5 1.1 0.1 -1.0 -0.7 0.9 0.9 0.3
High blood pressure (siblings) 0.5 0.8 2.6 0.0 0.9 1.6 -0.7 -0.7 0.6
Forced vital capacity (FVC), Best measure 0.5 2.0 3.7 -0.6 -1.6 -1.1 1.9 1.9 0.7
Body fat percentage 1.6 6.2 11.5 -2.0 -1.4 -2.4 3.3 3.4 -1.9
Leg fat percentage (right) 1.9 6.9 13.3 -1.9 -2.0 -1.8 3.6 3.6 -2.0
Arm fat-free mass (right) 1.4 7.0 14.7 -1.8 -2.0 -1.7 3.8 3.8 -1.7
Exposure to tobacco smoke outside home 0.3 0.4 1.5 -0.4 -0.8 -1.2 0.0 -0.0 -0.3
Comparative body size at age 10 0.1 0.3 0.9 -0.6 -0.4 -0.4 -0.1 0.1 -1.0
Number of full brothers 4.1 5.2 12.3 2.0 1.0 3.0 -1.5 -1.6 3.5
Worry too long after embarrassment 2.3 3.9 6.1 2.5 0.6 1.6 -2.2 -2.2 2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.4 3.6 -0.8 -0.6 0.2 1.8 1.9 0.6
Wheeze or whistling in the chest in last year 0.8 1.4 3.8 -1.9 1.1 -0.1 -0.8 -0.8 -1.4
Number of children fathered 0.5 0.5 2.4 0.5 0.1 -0.7 -0.1 -0.1 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.9 -0.0 0.9 -0.2 -0.6 -0.4 -0.5
Age at first live birth 0.2 0.4 1.0 -0.8 -0.5 0.4 -0.5 -0.4 -1.0
Pulse wave peak to peak time 0.4 0.5 1.0 0.6 0.5 0.3 -1.0 -1.0 0.6
Health satisfaction 0.7 0.9 2.1 -0.4 1.0 -1.4 1.1 1.1 -0.2
Shortness of breath walking on level ground 1.6 1.9 5.3 -0.1 0.1 0.7 2.3 2.3 -0.0
Qualifications: College or University degree 0.5 1.6 2.4 -0.8 -1.1 -1.4 1.5 1.6 -1.0
Eye problems/disorders: None of the above 2.3 2.7 6.1 0.7 0.9 2.5 -1.4 -1.5 2.1
Mouth/teeth dental problems: Loose teeth 1.4 1.7 4.1 1.7 -0.0 2.0 -0.7 -0.8 1.5
Emphysema/chronic bronchitis 0.5 0.6 1.0 -0.1 -0.3 -1.0 1.0 0.9 -0.9
Medication for pain relief, constipation, heartburn 0.7 1.3 2.5 1.6 -0.1 0.8 -1.5 -1.5 0.4
Neck or shoulder pain in last month 2.2 3.2 5.1 0.5 2.2 0.7 -2.3 -2.3 1.8
Medication: Blood pressure 0.5 0.9 1.6 -0.1 -0.1 -1.1 1.1 1.0 -1.3
Angina (self-reported) 1.6 2.1 4.6 -0.0 -1.0 -1.6 1.5 1.4 -2.1
Migraine (self-reported) 0.5 0.6 1.4 1.2 -0.8 -1.1 0.4 0.4 0.6
Medication: Ibuprofen 0.9 1.1 2.8 -1.7 1.6 0.9 -0.3 -0.2 0.6
Medication: Allopurinol 0.5 0.6 1.3 -0.1 0.4 0.8 1.1 1.1 0.7
Medication: Omeprazole 0.6 0.7 1.2 0.2 0.1 -1.1 1.0 1.1 -0.8
Medication: Seretide 50 evohaler 0.3 0.3 0.8 -0.4 -0.0 0.9 0.3 0.4 0.7
Mean time to correctly identify matches 1.0 1.8 3.8 -0.6 -1.7 0.1 1.9 1.9 0.6
Heart disease (mother) 1.9 2.4 6.5 -0.8 -2.5 -0.3 1.8 1.9 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.3 -0.5 0.6 1.1 -0.3 -0.2 0.4
Whole body fat mass 1.8 7.6 15.2 -2.2 -1.7 -2.2 3.8 3.9 -1.8
Leg fat mass (right) 2.0 7.9 16.2 -2.2 -1.7 -1.7 4.0 4.0 -2.2
Arm predicted mass (right) 1.3 6.5 13.8 -1.7 -2.0 -1.5 3.7 3.7 -1.6
Pulse rate, automated reading 11.8 38.0 106.1 1.8 3.3 0.6 -10.2 -10.3 -1.9
Alcohol intake frequency. 0.5 1.2 2.5 1.0 -1.6 1.3 0.0 -0.0 1.4
Comparative height size at age 10 0.3 1.6 3.4 -0.5 -1.9 -1.5 1.2 1.3 -0.8
Number of full sisters 0.6 0.7 1.6 0.9 0.2 0.2 -1.2 -1.3 0.2
Suffer from ‘nerves’ 1.0 1.5 5.2 2.3 -0.7 0.3 0.5 0.4 1.7
Overall health rating 0.8 1.6 2.8 -0.6 -0.5 -1.6 1.6 1.7 -1.2
Chest pain or discomfort 0.2 0.3 0.6 -0.8 -0.1 -0.6 -0.7 -0.7 0.1
Had major operations 1.5 1.7 3.6 0.0 1.8 1.9 -0.1 -0.2 1.9
Age at last live birth 0.3 0.4 1.1 1.0 -0.7 0.5 -0.7 -0.7 0.2
Family relationship satisfaction 0.7 0.8 2.0 -0.7 0.1 -0.3 -1.4 -1.4 -0.6
Leg pain on walking 2.2 2.8 6.8 -1.0 -0.3 -2.6 1.4 1.6 -2.0
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.6 0.8 -0.2 -0.2 -1.2 -1.2 0.0
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.3 -1.1 0.6 -0.1 -0.4 -0.5 -0.9
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 5.5 -0.6 -2.3 -0.2 -0.2 -0.0 -0.4
Medication: Aspirin 1.2 1.5 3.2 -1.0 -1.4 -0.5 1.7 1.8 0.0
Supplements: Vitamin C 1.7 2.0 3.4 1.0 1.6 1.9 -1.5 -1.5 0.9
Knee pain experienced in last month 1.0 1.6 2.7 0.9 -1.6 -0.0 1.6 1.6 0.8
Hypertension (Self-reported) 0.2 0.5 1.0 1.0 0.6 0.5 -0.7 -0.7 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.5 0.7 0.5 -0.5 0.5 0.6 0.6
Illnesses of father: Heart disease 0.8 1.1 2.4 -0.2 -1.2 -0.1 1.5 1.5 0.6
Illnesses of siblings: Diabetes 0.5 0.6 2.5 1.6 -0.6 -0.9 -0.1 -0.1 0.1
Smoking status: Previous 2.1 3.1 8.5 -1.0 -0.2 -0.0 2.8 2.9 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.4 -0.2 -1.2 -0.7 -0.5 -0.2 -0.2
Whole body fat-free mass 1.0 5.5 12.5 -0.9 -2.1 -1.3 3.5 3.5 -0.9
Leg fat-free mass (right) 0.7 3.5 7.9 -0.4 -1.8 -1.2 2.8 2.8 -0.6
Arm fat percentage (left) 1.6 6.3 13.0 -1.6 -1.8 -2.2 3.5 3.6 -1.3
Average weekly red wine intake 0.7 1.0 5.5 2.3 0.4 -0.7 -0.0 -0.1 0.3
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.9 0.5 1.0 0.2 -0.3 -0.2 0.2
Mood swings 0.7 1.3 3.3 -1.8 -1.5 -0.8 0.8 0.8 -0.6
Loneliness, isolation 1.9 2.6 4.5 -0.0 -2.1 -1.4 2.0 2.0 -0.9
Long-standing illness, disability or infirmity 0.9 1.3 4.1 -0.1 0.2 -0.3 1.9 2.0 0.4
Ever had bowel cancer screening 1.8 2.1 4.7 0.6 -0.9 -1.4 2.2 2.1 0.6
Diabetes diagnosed by doctor 1.1 1.7 4.5 0.2 -1.1 -0.6 2.1 2.1 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.9 -0.1 1.0 -0.2 -0.2 -0.2 -0.1
Friendships satisfaction 0.8 1.0 3.6 0.5 0.4 1.3 -0.4 -0.5 1.9
Qualifications: nursing, teaching 0.6 1.0 1.5 -0.2 -1.2 -1.0 1.0 1.0 -1.2
Commuting to job workplace: Walk 1.1 1.2 4.0 2.0 -0.9 0.0 0.1 0.1 1.5
Eye problems/disorders: Cataract 1.8 2.1 4.7 0.4 -1.8 -2.2 0.7 0.8 -1.8
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.0 -0.8 -1.0 0.4 -0.4 -0.5 0.6
Medication for cholesterol 0.5 0.7 1.9 1.4 -0.3 0.3 0.7 0.7 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.8 0.5 0.9 -0.6 -0.5 -0.7 -0.5
Back pain experienced in last month 0.2 0.3 0.7 0.9 -0.5 -0.5 -0.6 -0.6 0.1
Mineral and other dietary supplements 1.8 2.4 4.7 -2.1 -0.8 -0.5 1.6 1.4 -2.2
Breast cancer (self-reported) 1.3 1.6 3.6 -0.4 -1.1 -1.1 1.8 1.9 -0.2
Asthma (self-reported) 0.3 0.7 2.0 -0.8 1.4 0.0 -0.8 -0.6 -0.5
Osteoporosis (self-reported) 0.6 0.8 4.0 0.5 0.0 -2.0 0.1 0.1 -0.7
Osteoarthritis (self-reported) 0.6 0.8 2.3 1.5 -0.4 -0.7 1.0 0.9 0.4
Medication: Aspirin 1.4 1.8 4.0 -0.9 -1.2 -0.9 1.9 2.0 -0.2
Medication: Gliclazide 0.4 0.4 0.7 -0.8 -0.8 0.2 0.7 0.6 0.6
Illnesses of father: None of the above (group 1) 0.1 0.2 0.9 -0.9 -0.3 0.1 0.2 0.2 0.2
Smoking status: Current 1.6 2.5 7.1 1.7 2.7 -0.8 -1.3 -1.3 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 3.4 -1.9 -1.1 -0.3 0.6 0.6 0.1
Whole body water mass 1.0 5.7 13.3 -0.9 -2.2 -1.3 3.6 3.6 -0.8
Leg predicted mass (right) 0.7 3.6 8.0 -0.5 -1.9 -1.2 2.8 2.8 -0.6
Arm fat mass (left) 2.2 9.2 19.2 -1.8 -2.0 -2.6 4.3 4.4 -1.8
Number of self-reported non-cancer illnesses 0.4 0.6 2.4 0.8 0.2 -1.6 0.6 0.6 -0.2
Average weekly champagne plus white wine intake 0.3 0.4 1.3 -1.2 -0.2 0.4 -0.3 -0.4 -0.7
Miserableness 1.0 1.7 2.5 -1.5 -1.5 -0.7 1.6 1.5 0.2
Guilty feelings 1.1 1.6 4.1 -0.2 -2.0 -0.5 1.5 1.4 1.1
Wears glasses or contact lenses 0.8 0.9 1.4 0.1 1.2 0.5 1.2 1.2 1.0
Ever taken oral contraceptive pill 0.9 1.0 1.4 0.7 1.0 1.0 -1.2 -1.2 0.9
Hearing aid user 0.2 0.2 0.6 0.8 0.5 -0.3 -0.4 -0.3 0.1
Mother’s age at death 1.1 1.4 3.8 2.0 -1.2 0.6 -0.0 0.2 1.6
Financial situation satisfaction 0.3 0.4 1.2 -0.6 0.4 0.6 -0.2 -0.2 1.1
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.0 0.4 0.6 1.0 -0.8 -0.8 0.9
Commuting to job workplace: Public transport 0.7 0.8 2.6 0.0 0.4 -0.2 1.6 1.5 0.2
Eye problems/disorders: Glaucoma 0.9 1.1 2.6 -0.7 0.2 -1.6 0.9 1.0 -1.4
Medication: Blood pressure 0.1 0.1 0.6 -0.1 -0.3 -0.8 -0.0 -0.0 -0.3
Pain type(s) experienced in last month: Hip pain 1.4 1.7 6.1 0.5 -0.0 2.5 0.6 0.7 1.8
Supplements: Fish oil (including cod liver oil) 2.1 2.7 4.7 1.7 0.6 1.3 -1.9 -1.8 2.2
High cholesterol (Self-reported) 0.2 0.3 0.5 -0.6 0.0 -0.0 0.7 0.6 -0.6
Medication: Bendroflumethiazide 0.4 0.7 1.6 -1.2 -0.5 -0.3 -0.5 -0.5 -1.3
Medication: Paracetamol 0.5 0.8 3.3 -1.8 -0.2 0.4 0.8 0.8 0.2
Medication: Lisinopril 0.3 0.4 1.2 1.1 0.3 0.4 0.8 0.8 -0.3
Medication: Atorvastatin 0.3 0.3 1.5 0.1 -0.3 0.1 -0.5 -0.3 -1.2
Illnesses of father: High blood pressure 1.7 2.1 4.0 1.2 1.9 2.0 -1.0 -1.0 1.3
Alcohol drinker status: Never 3.1 3.7 6.2 -1.0 -2.4 -1.2 2.4 2.5 -1.5
Ever smoked 1.6 2.8 7.2 1.1 2.7 0.8 1.7 1.7 1.5
Basal metabolic rate 1.2 6.7 14.9 -1.3 -2.3 -1.5 3.9 3.9 -1.1
Leg fat percentage (left) 1.6 5.9 12.5 -1.9 -1.6 -1.5 3.4 3.5 -1.7
Arm fat-free mass (left) 1.8 9.1 19.3 -1.7 -2.5 -2.0 4.4 4.4 -1.6
Number of operations (self-reported) 0.4 0.6 1.6 0.7 1.2 0.6 -0.1 -0.1 1.3
Average weekly beer plus cider intake 0.8 1.2 3.4 1.6 -0.9 -0.3 0.0 0.0 1.9
Irritability 0.1 0.1 0.6 -0.8 0.2 0.1 0.3 0.2 0.1
Risk taking 0.2 0.3 1.2 0.6 -0.3 -1.1 0.5 0.5 -0.0
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.4 0.3 0.3 -0.0 -0.7 -0.6 -0.3
Fractured/broken bones in last 5 years 1.2 1.5 2.3 -0.3 -1.3 -1.5 1.4 1.5 -1.0
Age started oral contraceptive pill 1.3 1.6 4.4 -0.3 -1.2 -1.9 -0.2 -0.1 -2.1
Diastolic blood pressure, automated reading 2.4 7.3 20.1 1.2 1.4 0.1 -4.4 -4.5 -1.0
Ever depressed for a whole week 0.8 1.0 2.1 0.6 -0.3 0.7 -1.3 -1.2 1.4
Unable to work because of sickness or disability 2.6 3.4 9.5 -0.0 -0.1 -0.2 3.1 3.0 1.2
Commuting to job workplace: Cycle 1.5 1.8 2.4 1.5 0.7 1.2 -1.5 -1.4 1.6
Myopia 0.5 0.8 1.9 1.4 1.4 0.2 0.0 0.2 0.9
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.7 -0.3 -0.5 0.4 0.5 0.6 0.8
Cholesterol lowering medication 0.6 0.8 3.2 -0.4 -0.7 -1.8 0.2 0.3 -1.0
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 2.9 0.0 -0.6 -1.7 1.3 1.4 -1.1
Pain experienced in last month 0.2 0.4 0.8 0.6 0.2 0.7 0.9 0.8 0.3
Supplements: Calcium 0.3 0.3 1.0 -0.1 1.0 0.4 -0.4 -0.2 0.8
Basal cell carcinoma (self-reported) 0.9 1.1 2.2 -0.3 1.5 1.0 -1.3 -1.3 0.1
Heart attack/myocardial infarction (self-reported) 1.0 1.3 3.1 1.0 -0.7 -0.5 1.8 1.7 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.7 1.0 2.4 0.9 -0.9 1.1 0.5 0.5 1.6
Heart disease (siblings) 0.3 0.3 0.9 -0.6 -0.4 -0.6 0.2 0.3 -1.0
Alcohol drinker status: Previous 0.6 0.7 2.1 0.9 -1.4 0.1 0.5 0.4 1.0
Pack years of smoking 0.5 0.8 2.4 -0.3 -0.9 -1.6 0.6 0.6 -0.8
Impedance of whole body 1.1 5.4 14.0 -0.4 2.2 -0.2 -3.7 -3.6 0.1
Leg fat mass (left) 2.0 7.7 16.1 -2.2 -1.6 -1.7 3.9 4.0 -2.0
Arm predicted mass (left) 1.5 7.8 17.1 -1.3 -2.1 -1.9 4.1 4.1 -1.6