Hub : Genes

GNB4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.062	0.0290	8.6e-03	0.028	0.019	0.034	0.023	0.034	2.0e-04	0.0018	5.3e-05	0.00063	4.3e-05
2	GTEx	Artery Aorta	0.163	0.0640	1.8e-03	0.022	NA	0.065	NA	0.048	2.2e-02	NA	1.8e-04	NA	1.2e-03
3	GTEx	Esophagus Mucosa	0.116	0.0490	3.6e-03	0.001	NA	0.030	NA	0.011	2.8e-01	NA	4.1e-03	NA	5.4e-02
4	GTEx	Heart Atrial Appendage	0.560	0.0680	2.3e-11	0.453	NA	0.330	NA	0.423	2.0e-22	NA	1.7e-15	NA	1.3e-20
5	GTEx	Heart Left Ventricle	0.451	0.0733	6.1e-10	0.284	NA	0.328	NA	0.347	1.9e-15	NA	4.7e-18	NA	3.0e-19
6	TCGA	Lung Adenocarcinoma	0.062	0.0346	1.3e-03	0.011	0.018	0.016	NA	0.013	1.6e-02	0.0032	4.9e-03	NA	1.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.5	2.4	5.7	-0.2	-2.4	-1.6	1.8	1.6	-0.4
Bipolar Disorder or Schizophrenia	0.4	0.9	2.3	0.5	-1.5	-1.4	0.8	0.7	0.2
Depressed Affect (Nagel 2018)	1.1	2.4	3.8	-1.6	-2.0	-1.5	1.6	1.6	-0.4
Depression (Nagel 2018)	1.1	1.7	6.9	-2.6	0.9	-0.6	-0.3	-0.3	-1.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	-0.9	0.7	-0.2	-0.2	-0.1	-0.9
Neuroticism (Nagel 2018)	0.4	0.8	2.6	0.0	-1.6	-1.0	0.7	0.7	0.7
Schizophrenia (2018)	0.1	0.3	0.6	0.8	-0.0	-0.5	-0.4	-0.4	0.6
Schizophrenia vs Biploar Disorder	0.4	0.6	1.4	0.2	-0.4	0.6	-1.2	-1.2	0.1
Worry (Nagel 2018)	0.5	1.1	3.5	1.2	-1.2	-0.3	0.2	0.3	1.9
Alzheimer’s Disease (in mother)	0.7	0.8	2.6	0.4	-1.6	-0.9	0.7	0.7	0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.1	0.4	0.6	-0.5	-0.5	0.2
Alzheimer’s Disease (including proxy)	0.3	0.5	0.7	0.8	-0.6	-0.9	0.4	0.4	0.8
Crohns Disease (2017)	0.5	1.1	4.0	0.2	2.0	-0.6	0.7	0.7	1.0
Irritable Bowel Disease (IBD)	0.3	0.7	3.1	-0.9	1.8	-0.0	-0.4	-0.5	0.0
Ulcerative Colitis (UC)	0.3	0.6	1.5	-1.2	0.7	0.6	-0.7	-0.8	-0.4
Major Depression (MDD)	1.1	1.3	2.2	-1.4	-0.6	0.3	1.5	1.5	-1.1
Reaction Time	0.9	1.7	3.3	-0.9	-1.8	-0.5	1.8	1.7	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.6	0.5	0.2	-0.5	-0.3	-0.2
Breast Cancer	1.6	3.9	8.0	2.4	2.8	0.7	-2.1	-2.1	0.7
Ovarian Cancer	0.2	0.3	0.9	0.7	-0.9	-0.5	-0.2	-0.3	-0.2
Prostate Cancer	1.6	2.2	5.0	-2.2	2.2	-0.2	1.2	1.3	-0.6
Age at First Birth	0.1	0.2	0.4	0.7	-0.5	0.2	-0.4	-0.5	0.1
Bipolar Disorder (2011)	1.5	1.4	3.2	0.4	-0.6	0.4	1.8	1.7	1.3
Body Mass Index (BMI) (2010)	0.7	1.0	3.2	-0.2	0.6	1.8	-0.6	-0.5	1.3
Coronary Artery Disease (CAD)	1.5	1.8	3.2	1.2	-1.8	-0.2	1.8	1.7	0.6
Crohns Disease (2012)	1.0	1.6	3.0	-1.0	1.5	1.6	0.7	0.6	1.7
Mean Putamen Volume	0.5	0.5	2.2	1.0	-0.1	0.1	-0.2	-0.2	1.5
Fasting Glucose	1.4	1.7	3.8	2.0	-1.8	-1.4	0.2	0.4	-0.8
HbA1C	0.9	1.0	2.7	1.3	-1.6	-1.1	0.2	0.2	0.2
HDL Cholesterol	0.6	0.9	1.9	0.1	-0.4	-0.7	-1.3	-1.4	-1.1
LDL Cholesterol	0.4	0.7	1.6	0.5	0.9	0.1	-1.1	-1.3	-0.4
Lupus	0.8	1.1	3.6	0.1	-0.5	-1.9	0.7	0.7	-1.4
Neuroticism (2016)	0.5	0.7	1.6	1.2	1.1	-0.7	-0.6	-0.6	-0.2
Primary Biliary Cirrhosis	0.7	1.0	2.4	1.2	-1.1	-1.5	0.5	0.5	-0.7
Rheumatoid Arthritis	0.2	0.2	0.5	0.2	0.7	-0.3	0.5	0.3	0.5
Schizophrenia (2014)	0.1	0.2	0.8	-0.6	-0.3	-0.9	-0.1	-0.1	0.5
Triglycerides	0.1	0.2	0.4	-0.3	0.7	0.2	-0.6	-0.6	0.0
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.1	-0.7	-0.8	-0.4	1.3	1.4	1.4
Ulcerative Colitis	0.3	0.5	2.4	-1.6	0.2	0.6	0.3	0.2	-0.4
Blood Eosinophil Count	0.2	1.8	5.4	-1.1	1.4	-1.1	0.8	0.8	-2.3
Blood Platelet Count	0.3	3.4	6.8	-1.3	2.6	-1.3	-1.8	-1.5	-2.2
Blood Red Count	0.2	1.6	4.5	-0.1	1.6	-2.1	0.7	0.9	-1.1
Blood White Count	0.4	2.7	8.5	-1.9	1.9	-0.5	-0.2	-0.1	-2.9
Heel T-Score	0.1	0.5	1.5	1.2	0.7	-0.2	-0.4	-0.4	0.7
BMI	1.0	6.0	12.0	-2.4	-1.1	-1.7	3.4	3.5	-1.6
Height	0.1	2.2	5.7	-0.9	-1.4	-2.4	0.7	0.7	-2.0
Waist Hip Ratio (WHR)	0.4	1.9	5.2	-2.3	-0.0	-1.0	0.7	0.7	-2.0
Systolic Blood Pressure	0.5	2.4	5.2	1.0	1.5	0.9	-2.3	-2.2	-0.3
Smoking Status	0.6	1.4	6.8	0.8	2.6	-0.7	-0.1	-0.0	-0.6
Allergy or Eczema	1.0	2.6	4.5	1.8	0.9	0.6	-2.1	-2.1	1.6
Cardiovascular Disease	0.7	2.2	5.3	0.9	0.9	1.1	-2.2	-2.3	0.1
Hypothyroidism (self reported)	0.3	0.8	1.3	0.2	-1.0	-0.1	1.1	1.1	-1.0
Respiratory disease	0.2	0.5	1.8	-0.1	1.3	0.2	-0.9	-0.7	0.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.6	0.0	-0.3	0.3	1.3	1.2	0.6
Lung FEV1/FVC ratio	0.2	0.9	2.1	-1.4	-0.1	0.4	1.1	1.1	0.7
Lung FVC	0.2	0.8	2.1	-0.4	-1.4	-0.2	1.2	1.1	0.3
Neuroticism	0.1	0.2	0.7	-0.3	-0.8	-0.3	-0.2	-0.1	0.7
Chronotype (morning person)	1.3	3.0	8.4	0.1	-1.6	-2.9	1.1	1.0	-2.2
Hair Pigment	0.1	2.4	8.6	1.2	0.2	1.0	1.4	1.2	2.9
Tanning	0.1	1.5	2.8	0.7	1.3	-1.0	-1.7	-1.6	-0.7
Hand grip strength (left)	0.6	1.5	3.9	1.5	-0.7	1.6	0.0	0.0	2.0
Number of treatments/medications taken	0.8	1.4	3.5	-0.8	-0.6	-0.8	1.9	1.9	-0.2
Average weekly spirits intake	1.4	1.8	4.9	2.2	-0.8	1.1	-0.4	-0.3	1.9
Sensitivity / hurt feelings	0.3	0.5	1.1	-0.1	-1.0	-0.0	-0.9	-1.0	0.2
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.9	-1.7	-1.1	-1.1	0.3	0.2	-0.8
Hearing difficulty/problems: Yes	0.3	0.5	1.6	0.4	0.1	1.0	-0.2	-0.1	1.3
Relative age of first facial hair	0.4	0.7	1.8	1.3	1.4	0.4	-0.1	-0.1	0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.8	0.7	0.3	-0.9	0.8	0.9	-0.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.0	-0.6	-1.0	-0.7	0.9	0.9	-0.5
Ever had hysterectomy (womb removed)	1.1	1.2	2.4	-0.7	-0.3	-0.9	1.5	1.6	-1.0
Systolic blood pressure, automated reading	0.5	1.4	1.9	1.3	0.3	-1.4	-1.4	-1.3	-1.1
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.2	0.4	-0.8	-1.8	0.8	0.9	-1.1
Angina	1.7	2.2	5.0	-0.0	-1.2	-1.7	1.5	1.4	-2.2
Medication for hormone replacement therapy	0.9	1.0	2.0	-1.0	1.2	1.4	-0.8	-0.9	0.1
Vitamin and mineral supplements	0.9	1.2	2.0	-0.6	-1.3	-1.0	1.3	1.4	-0.2
Supplements: Zinc	0.8	0.9	3.0	1.7	-0.2	0.3	0.6	0.8	1.1
Medication: Co-codamol	0.2	0.2	0.8	-0.3	-0.2	-0.0	0.3	0.3	-0.9
Medication: Metformin	0.8	1.1	2.2	-0.4	-1.4	-0.2	1.5	1.5	0.5
Diabetes (father)	0.8	1.0	4.0	2.0	-1.1	-0.7	0.2	0.2	-0.7
Diabetes (mother)	2.5	3.1	4.8	0.5	-1.8	-1.6	2.2	2.1	-1.9
Severe depression (siblings)	0.2	0.3	0.5	0.3	0.6	-0.2	-0.7	-0.7	-0.3
Pack years adult smoking proportion	0.3	0.5	2.0	-0.1	-0.7	-1.4	0.2	0.2	-0.7
Impedance of leg (right)	0.4	2.1	4.6	-1.3	1.1	-0.1	-2.1	-2.1	-0.8
Leg fat-free mass (left)	0.9	4.5	9.6	-0.7	-2.2	-1.5	3.1	3.0	-0.9
Trunk fat percentage	1.6	6.5	10.7	-2.2	-1.3	-2.9	3.2	3.3	-1.9
Hand grip strength (right)	0.5	1.4	2.9	1.7	-1.5	0.4	-0.7	-0.6	1.5
Townsend deprivation index at recruitment	0.6	0.8	1.6	1.3	-0.9	-0.8	0.3	0.5	1.1
Current tobacco smoking	1.8	3.0	8.8	1.9	3.0	-0.5	-1.6	-1.6	-0.6
Average weekly fortified wine intake	0.2	0.2	0.8	0.5	-0.0	0.9	-0.4	-0.5	0.0
Maternal smoking around birth	1.2	1.7	4.0	-0.4	0.5	-1.7	-1.1	-1.3	-2.0
Fed-up feelings	0.6	1.0	3.7	-0.3	-1.9	-1.1	0.6	0.6	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	2.0	-1.4	0.9	-0.3	0.1	-0.0	-0.7
Relative age voice broke	0.6	0.9	2.2	0.7	1.5	0.3	-0.4	-0.3	1.5
Taking other prescription medications	0.2	0.4	0.8	0.9	0.2	-0.0	0.7	0.8	0.4
Age when periods started (menarche)	0.0	0.1	0.2	-0.3	0.4	-0.5	-0.3	-0.4	0.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.9	0.9	-0.3	-0.2	-0.3	-0.5	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	-0.5	0.1	-0.0	-0.7	-0.8	-0.5
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.8	-0.7	-0.0	-0.2	1.3	1.3	0.7
Qualifications: CSEs or equivalent	0.2	0.3	0.5	-0.5	0.5	0.7	-0.2	-0.3	0.7
Serious illness, injury or assault to yourself	1.1	1.4	5.2	-1.0	2.3	-0.8	0.7	0.6	-0.7
High blood pressure	0.2	0.6	1.2	0.7	0.8	0.4	-1.1	-1.1	0.2
Hayfever, allergic rhinitis or eczema	0.7	1.6	4.2	0.8	0.7	-0.0	-2.0	-2.0	0.6
Multivitamins +/- minerals	0.2	0.2	1.1	0.1	1.0	0.1	-0.3	-0.4	0.2
Stomach or abdominal pain in last month	0.4	0.5	1.2	-0.1	-0.9	-1.1	0.0	-0.1	-0.9
Supplements: Glucosamine	1.2	1.6	2.8	0.5	1.7	1.2	-1.3	-1.3	1.3
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	6.2	-0.6	-2.5	-2.3	1.1	0.9	-1.3
Medication: Atenolol	0.7	0.9	2.3	0.8	-1.0	-1.5	-0.1	-0.2	-1.2
Medication: Levothyroxine sodium	0.2	0.4	0.8	0.4	0.3	0.7	0.9	0.8	0.4
Sitting height	0.0	0.3	0.7	0.9	-0.7	-0.4	0.3	0.2	0.5
Chronic bronchitis/emphysema (father)	0.7	0.8	1.4	0.6	0.8	-0.9	-1.2	-1.1	-0.6
High blood pressure (mother)	0.7	1.0	2.2	-1.0	0.0	1.5	-0.9	-0.7	1.2
Body mass index (BMI)	1.9	8.3	19.7	-1.4	-1.9	-1.6	4.4	4.4	-1.4
Impedance of leg (left)	0.5	2.5	5.3	-1.3	1.7	0.3	-2.3	-2.2	-0.4
Leg predicted mass (left)	0.9	4.5	9.4	-0.7	-2.3	-1.5	3.1	3.0	-0.9
Trunk fat mass	1.8	7.8	14.5	-2.5	-1.6	-2.6	3.7	3.8	-1.9
Waist circumference	1.7	6.4	16.1	-1.2	-1.0	-1.7	3.9	4.0	-1.2
Number of incorrect matches in round	0.2	0.3	1.1	1.0	0.2	0.2	0.0	0.0	0.8
Past tobacco smoking	1.4	2.6	6.2	-0.7	-1.1	0.0	-2.4	-2.5	-1.3
Alcohol usually taken with meals	0.4	0.7	2.5	-0.0	0.5	1.6	-0.8	-0.9	-0.0
Nervous feelings	1.2	2.2	4.9	2.2	-1.3	0.6	1.3	1.3	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	4.5	-0.1	-2.1	-0.3	0.8	0.8	-0.1
Hearing difficulty/problems with background noise	1.3	2.0	7.0	2.6	-0.5	0.6	-0.8	-0.8	1.8
Hair/balding pattern: Pattern 2	0.6	0.8	2.0	0.4	0.8	0.1	-1.2	-1.4	-0.6
Had menopause	1.7	2.1	6.1	-0.6	-1.2	-2.5	1.1	1.1	-1.6
Had other major operations	1.3	1.6	3.4	0.6	1.5	-0.1	-1.8	-1.7	-0.4
Forced vital capacity (FVC)	0.3	1.2	2.2	-0.6	-1.2	-1.1	1.4	1.5	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.9	-0.5	0.9	0.3	-1.7	-1.7	-0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.9	0.9	-1.4	-0.4	0.3	0.3	0.5
Qualifications: None of the above	0.4	0.9	1.9	1.4	-1.3	0.3	-0.7	-0.7	0.9
Financial difficulties in last 2 years	1.3	1.8	3.8	-1.9	1.6	-1.1	0.4	0.4	-1.7
Mouth/teeth dental problems	0.4	0.6	1.8	-1.3	0.9	-0.3	-0.2	0.1	-1.0
Heart attack	1.1	1.4	3.6	0.8	-0.8	-0.5	1.9	1.8	-0.0
Allergy	0.4	0.9	2.3	-0.3	-0.8	-0.4	1.5	1.5	-0.6
Pain all over the body in last month	0.4	0.5	1.0	0.9	-0.1	-1.0	0.5	0.5	-0.7
Diabetes (self-reported)	0.8	1.2	3.1	0.5	-0.3	-0.8	1.8	1.7	0.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.6	0.2	-1.3	-1.2	-0.7	-0.6	-0.1
Medication: Ramipril	0.4	0.5	1.3	1.1	0.7	-0.7	0.4	0.4	-0.4
Medication: Simvastatin	0.9	1.3	2.2	-0.4	-0.5	-1.5	1.5	1.5	-0.9
Fluid intelligence score	0.2	0.4	1.0	-0.7	1.0	0.6	-0.4	-0.2	-0.6
Illnesses of siblings	0.0	0.1	0.3	-0.5	0.2	-0.1	-0.0	0.0	-0.1
Neuroticism score	0.2	0.4	1.1	-0.2	-1.0	0.2	0.2	0.2	1.1
Weight	1.7	8.6	18.6	-1.8	-2.1	-2.1	4.3	4.3	-1.6
Impedance of arm (right)	1.2	5.6	15.0	0.6	1.8	0.2	-3.9	-3.8	1.0
Arm fat percentage (right)	1.6	6.3	14.1	-1.4	-1.8	-2.0	3.7	3.8	-1.1
Trunk fat-free mass	0.9	5.2	12.3	-1.0	-2.0	-0.9	3.5	3.5	-0.7
Hip circumference	1.1	4.9	13.8	-0.8	-1.0	-1.0	3.6	3.7	-0.0
Time employed in main current job	1.0	1.1	2.6	1.2	-0.9	-0.3	0.9	1.0	1.6
Alcohol intake versus 10 years previously	0.6	0.9	1.6	0.9	1.3	0.5	-1.0	-1.0	0.6
Father’s age at death	0.1	0.1	0.4	0.0	-0.1	0.6	0.2	0.2	-0.1
Worrier / anxious feelings	0.4	0.8	2.8	0.5	-1.7	-1.3	-0.2	-0.2	0.0
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.4	0.6	1.6	-0.3	-1.7	-1.9	-0.5
Falls in the last year	1.6	2.1	4.3	0.3	-0.9	-1.9	1.9	2.1	-0.0
Hair/balding pattern: Pattern 3	0.4	0.6	2.2	-1.5	0.7	0.5	0.4	0.5	0.4
Number of live births	0.5	0.7	1.6	1.0	0.4	-0.4	0.7	0.8	1.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.1	-1.0	-0.6	-0.5	1.0	1.0	0.6
Pulse rate	4.4	7.5	21.5	1.8	0.4	0.2	-4.5	-4.6	-0.3
Happiness	0.6	0.7	2.1	-0.4	-1.4	-0.3	1.1	1.0	-0.1
Noisy workplace	0.4	0.5	1.3	0.9	0.4	-0.4	0.4	0.4	1.2
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.6	-1.0	-1.2	-0.0	1.2	1.2	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	3.0	1.7	-0.4	0.5	0.3	0.1	1.0
Mouth/teeth dental problems: Dentures	0.9	1.5	6.8	2.6	-1.0	-1.0	-0.2	-0.3	0.3
Asthma	0.2	0.3	0.8	-0.9	0.8	-0.4	-0.4	-0.2	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	5.6	-2.2	2.4	1.1	-0.7	-0.7	0.7
Medication: Cholesterol lowering	0.4	0.6	1.3	-0.5	-0.2	-0.4	1.1	1.1	-0.9
Depression (self-reported)	0.4	0.5	1.5	1.2	0.0	1.1	0.3	0.1	0.6
Medication: Lansoprazole	1.0	1.2	2.4	0.2	-0.9	-1.6	1.2	1.3	-0.7
Prospective memory result	1.1	1.4	3.2	0.3	-1.8	-1.7	0.5	0.4	-1.2
Lung cancer (father)	0.5	0.6	2.8	1.7	0.3	-0.5	-0.3	-0.3	0.3
Illnesses of mother	0.3	0.3	1.0	0.0	0.9	-0.2	0.3	0.2	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	2.9	-1.4	-1.4	-0.3	1.7	1.6	1.1
Pulse wave Arterial Stiffness index	0.6	0.7	1.1	-0.7	-0.6	-0.5	1.0	1.0	-1.0
Impedance of arm (left)	1.2	5.7	15.7	0.4	1.6	-0.3	-4.0	-3.9	0.8
Arm fat mass (right)	2.2	9.1	19.8	-1.8	-2.1	-2.4	4.4	4.5	-1.6
Trunk predicted mass	0.9	5.1	12.0	-1.0	-2.1	-0.9	3.5	3.5	-0.7
Standing height	0.1	0.7	2.2	-1.1	-0.5	-1.5	0.1	0.2	-0.8
Length of working week for main job	0.4	0.5	1.1	-0.4	-0.2	-0.3	1.0	1.1	0.7
Exposure to tobacco smoke at home	0.3	0.3	0.7	-0.2	-0.0	-0.2	-0.8	-0.8	-0.7
Breastfed as a baby	1.0	1.3	2.8	-0.3	-1.4	0.0	1.7	1.7	-0.0
Tense / ‘highly strung’	0.4	0.6	1.4	-0.0	-0.9	-0.2	-1.1	-1.2	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.7	-1.3	-1.0	-0.3	1.0	0.9	-1.0
Hair/balding pattern: Pattern 4	0.8	1.9	5.6	2.4	0.3	0.8	0.0	0.0	2.2
Birth weight of first child	1.3	2.4	10.4	-3.2	-1.2	-0.6	0.3	0.2	-1.4
Peak expiratory flow (PEF)	0.3	0.8	2.8	0.7	0.6	0.8	0.3	0.4	1.7
Pulse wave reflection index	1.8	2.2	4.7	-0.8	-0.0	-1.5	2.1	2.2	-1.2
Ever highly irritable/argumentative for 2 days	1.8	2.1	3.4	1.8	0.9	-0.9	-1.8	-1.8	-1.1
Loud music exposure frequency	0.2	0.2	0.8	-0.9	0.1	0.2	-0.2	-0.2	0.5
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.7	-0.6	0.7	-1.0	1.3	1.3	-0.9
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.3	0.4	0.4	0.1	-0.1	-0.5
Blood clot in the leg (DVT)	0.9	1.1	2.8	1.1	-1.1	1.0	0.5	0.5	1.7
Medication: Paracetamol	0.5	0.8	4.2	-2.0	-0.2	-0.2	0.3	0.4	-0.3
Headache pain in last month	0.5	0.8	4.3	-2.1	-0.5	0.3	0.3	0.2	-0.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.1	-0.0	0.5	1.3	-1.4	-1.3	1.4
Glaucoma (self-reported)	1.6	1.9	4.0	-1.6	0.6	-1.4	1.0	1.2	-2.0
Gout (self-reported)	0.6	0.8	1.7	-0.9	0.4	0.2	1.3	1.3	0.8
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	5.3	-0.2	-0.4	0.2	2.3	2.3	-0.1
Medication: Amlodipine	0.2	0.3	1.0	0.7	0.3	-1.0	-0.1	-0.2	-0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.0	0.6	1.0	0.0	-0.6	-0.6	0.4
Birth weight	0.9	2.0	7.7	-2.8	-0.6	-1.2	0.3	0.3	-1.5
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.1	0.1	-1.0	-0.7	0.9	0.9	0.3
High blood pressure (siblings)	0.5	0.8	2.6	0.0	0.9	1.6	-0.7	-0.7	0.6
Forced vital capacity (FVC), Best measure	0.5	2.0	3.7	-0.6	-1.6	-1.1	1.9	1.9	0.7
Body fat percentage	1.6	6.2	11.5	-2.0	-1.4	-2.4	3.3	3.4	-1.9
Leg fat percentage (right)	1.9	6.9	13.3	-1.9	-2.0	-1.8	3.6	3.6	-2.0
Arm fat-free mass (right)	1.4	7.0	14.7	-1.8	-2.0	-1.7	3.8	3.8	-1.7
Exposure to tobacco smoke outside home	0.3	0.4	1.5	-0.4	-0.8	-1.2	0.0	-0.0	-0.3
Comparative body size at age 10	0.1	0.3	0.9	-0.6	-0.4	-0.4	-0.1	0.1	-1.0
Number of full brothers	4.1	5.2	12.3	2.0	1.0	3.0	-1.5	-1.6	3.5
Worry too long after embarrassment	2.3	3.9	6.1	2.5	0.6	1.6	-2.2	-2.2	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.4	3.6	-0.8	-0.6	0.2	1.8	1.9	0.6
Wheeze or whistling in the chest in last year	0.8	1.4	3.8	-1.9	1.1	-0.1	-0.8	-0.8	-1.4
Number of children fathered	0.5	0.5	2.4	0.5	0.1	-0.7	-0.1	-0.1	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.9	-0.0	0.9	-0.2	-0.6	-0.4	-0.5
Age at first live birth	0.2	0.4	1.0	-0.8	-0.5	0.4	-0.5	-0.4	-1.0
Pulse wave peak to peak time	0.4	0.5	1.0	0.6	0.5	0.3	-1.0	-1.0	0.6
Health satisfaction	0.7	0.9	2.1	-0.4	1.0	-1.4	1.1	1.1	-0.2
Shortness of breath walking on level ground	1.6	1.9	5.3	-0.1	0.1	0.7	2.3	2.3	-0.0
Qualifications: College or University degree	0.5	1.6	2.4	-0.8	-1.1	-1.4	1.5	1.6	-1.0
Eye problems/disorders: None of the above	2.3	2.7	6.1	0.7	0.9	2.5	-1.4	-1.5	2.1
Mouth/teeth dental problems: Loose teeth	1.4	1.7	4.1	1.7	-0.0	2.0	-0.7	-0.8	1.5
Emphysema/chronic bronchitis	0.5	0.6	1.0	-0.1	-0.3	-1.0	1.0	0.9	-0.9
Medication for pain relief, constipation, heartburn	0.7	1.3	2.5	1.6	-0.1	0.8	-1.5	-1.5	0.4
Neck or shoulder pain in last month	2.2	3.2	5.1	0.5	2.2	0.7	-2.3	-2.3	1.8
Medication: Blood pressure	0.5	0.9	1.6	-0.1	-0.1	-1.1	1.1	1.0	-1.3
Angina (self-reported)	1.6	2.1	4.6	-0.0	-1.0	-1.6	1.5	1.4	-2.1
Migraine (self-reported)	0.5	0.6	1.4	1.2	-0.8	-1.1	0.4	0.4	0.6
Medication: Ibuprofen	0.9	1.1	2.8	-1.7	1.6	0.9	-0.3	-0.2	0.6
Medication: Allopurinol	0.5	0.6	1.3	-0.1	0.4	0.8	1.1	1.1	0.7
Medication: Omeprazole	0.6	0.7	1.2	0.2	0.1	-1.1	1.0	1.1	-0.8
Medication: Seretide 50 evohaler	0.3	0.3	0.8	-0.4	-0.0	0.9	0.3	0.4	0.7
Mean time to correctly identify matches	1.0	1.8	3.8	-0.6	-1.7	0.1	1.9	1.9	0.6
Heart disease (mother)	1.9	2.4	6.5	-0.8	-2.5	-0.3	1.8	1.9	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.3	-0.5	0.6	1.1	-0.3	-0.2	0.4
Whole body fat mass	1.8	7.6	15.2	-2.2	-1.7	-2.2	3.8	3.9	-1.8
Leg fat mass (right)	2.0	7.9	16.2	-2.2	-1.7	-1.7	4.0	4.0	-2.2
Arm predicted mass (right)	1.3	6.5	13.8	-1.7	-2.0	-1.5	3.7	3.7	-1.6
Pulse rate, automated reading	11.8	38.0	106.1	1.8	3.3	0.6	-10.2	-10.3	-1.9
Alcohol intake frequency.	0.5	1.2	2.5	1.0	-1.6	1.3	0.0	-0.0	1.4
Comparative height size at age 10	0.3	1.6	3.4	-0.5	-1.9	-1.5	1.2	1.3	-0.8
Number of full sisters	0.6	0.7	1.6	0.9	0.2	0.2	-1.2	-1.3	0.2
Suffer from ‘nerves’	1.0	1.5	5.2	2.3	-0.7	0.3	0.5	0.4	1.7
Overall health rating	0.8	1.6	2.8	-0.6	-0.5	-1.6	1.6	1.7	-1.2
Chest pain or discomfort	0.2	0.3	0.6	-0.8	-0.1	-0.6	-0.7	-0.7	0.1
Had major operations	1.5	1.7	3.6	0.0	1.8	1.9	-0.1	-0.2	1.9
Age at last live birth	0.3	0.4	1.1	1.0	-0.7	0.5	-0.7	-0.7	0.2
Family relationship satisfaction	0.7	0.8	2.0	-0.7	0.1	-0.3	-1.4	-1.4	-0.6
Leg pain on walking	2.2	2.8	6.8	-1.0	-0.3	-2.6	1.4	1.6	-2.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.6	0.8	-0.2	-0.2	-1.2	-1.2	0.0
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	-1.1	0.6	-0.1	-0.4	-0.5	-0.9
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	5.5	-0.6	-2.3	-0.2	-0.2	-0.0	-0.4
Medication: Aspirin	1.2	1.5	3.2	-1.0	-1.4	-0.5	1.7	1.8	0.0
Supplements: Vitamin C	1.7	2.0	3.4	1.0	1.6	1.9	-1.5	-1.5	0.9
Knee pain experienced in last month	1.0	1.6	2.7	0.9	-1.6	-0.0	1.6	1.6	0.8
Hypertension (Self-reported)	0.2	0.5	1.0	1.0	0.6	0.5	-0.7	-0.7	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.5	0.7	0.5	-0.5	0.5	0.6	0.6
Illnesses of father: Heart disease	0.8	1.1	2.4	-0.2	-1.2	-0.1	1.5	1.5	0.6
Illnesses of siblings: Diabetes	0.5	0.6	2.5	1.6	-0.6	-0.9	-0.1	-0.1	0.1
Smoking status: Previous	2.1	3.1	8.5	-1.0	-0.2	-0.0	2.8	2.9	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.4	-0.2	-1.2	-0.7	-0.5	-0.2	-0.2
Whole body fat-free mass	1.0	5.5	12.5	-0.9	-2.1	-1.3	3.5	3.5	-0.9
Leg fat-free mass (right)	0.7	3.5	7.9	-0.4	-1.8	-1.2	2.8	2.8	-0.6
Arm fat percentage (left)	1.6	6.3	13.0	-1.6	-1.8	-2.2	3.5	3.6	-1.3
Average weekly red wine intake	0.7	1.0	5.5	2.3	0.4	-0.7	-0.0	-0.1	0.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.9	0.5	1.0	0.2	-0.3	-0.2	0.2
Mood swings	0.7	1.3	3.3	-1.8	-1.5	-0.8	0.8	0.8	-0.6
Loneliness, isolation	1.9	2.6	4.5	-0.0	-2.1	-1.4	2.0	2.0	-0.9
Long-standing illness, disability or infirmity	0.9	1.3	4.1	-0.1	0.2	-0.3	1.9	2.0	0.4
Ever had bowel cancer screening	1.8	2.1	4.7	0.6	-0.9	-1.4	2.2	2.1	0.6
Diabetes diagnosed by doctor	1.1	1.7	4.5	0.2	-1.1	-0.6	2.1	2.1	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.9	-0.1	1.0	-0.2	-0.2	-0.2	-0.1
Friendships satisfaction	0.8	1.0	3.6	0.5	0.4	1.3	-0.4	-0.5	1.9
Qualifications: nursing, teaching	0.6	1.0	1.5	-0.2	-1.2	-1.0	1.0	1.0	-1.2
Commuting to job workplace: Walk	1.1	1.2	4.0	2.0	-0.9	0.0	0.1	0.1	1.5
Eye problems/disorders: Cataract	1.8	2.1	4.7	0.4	-1.8	-2.2	0.7	0.8	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.0	-0.8	-1.0	0.4	-0.4	-0.5	0.6
Medication for cholesterol	0.5	0.7	1.9	1.4	-0.3	0.3	0.7	0.7	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	0.5	0.9	-0.6	-0.5	-0.7	-0.5
Back pain experienced in last month	0.2	0.3	0.7	0.9	-0.5	-0.5	-0.6	-0.6	0.1
Mineral and other dietary supplements	1.8	2.4	4.7	-2.1	-0.8	-0.5	1.6	1.4	-2.2
Breast cancer (self-reported)	1.3	1.6	3.6	-0.4	-1.1	-1.1	1.8	1.9	-0.2
Asthma (self-reported)	0.3	0.7	2.0	-0.8	1.4	0.0	-0.8	-0.6	-0.5
Osteoporosis (self-reported)	0.6	0.8	4.0	0.5	0.0	-2.0	0.1	0.1	-0.7
Osteoarthritis (self-reported)	0.6	0.8	2.3	1.5	-0.4	-0.7	1.0	0.9	0.4
Medication: Aspirin	1.4	1.8	4.0	-0.9	-1.2	-0.9	1.9	2.0	-0.2
Medication: Gliclazide	0.4	0.4	0.7	-0.8	-0.8	0.2	0.7	0.6	0.6
Illnesses of father: None of the above (group 1)	0.1	0.2	0.9	-0.9	-0.3	0.1	0.2	0.2	0.2
Smoking status: Current	1.6	2.5	7.1	1.7	2.7	-0.8	-1.3	-1.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.4	-1.9	-1.1	-0.3	0.6	0.6	0.1
Whole body water mass	1.0	5.7	13.3	-0.9	-2.2	-1.3	3.6	3.6	-0.8
Leg predicted mass (right)	0.7	3.6	8.0	-0.5	-1.9	-1.2	2.8	2.8	-0.6
Arm fat mass (left)	2.2	9.2	19.2	-1.8	-2.0	-2.6	4.3	4.4	-1.8
Number of self-reported non-cancer illnesses	0.4	0.6	2.4	0.8	0.2	-1.6	0.6	0.6	-0.2
Average weekly champagne plus white wine intake	0.3	0.4	1.3	-1.2	-0.2	0.4	-0.3	-0.4	-0.7
Miserableness	1.0	1.7	2.5	-1.5	-1.5	-0.7	1.6	1.5	0.2
Guilty feelings	1.1	1.6	4.1	-0.2	-2.0	-0.5	1.5	1.4	1.1
Wears glasses or contact lenses	0.8	0.9	1.4	0.1	1.2	0.5	1.2	1.2	1.0
Ever taken oral contraceptive pill	0.9	1.0	1.4	0.7	1.0	1.0	-1.2	-1.2	0.9
Hearing aid user	0.2	0.2	0.6	0.8	0.5	-0.3	-0.4	-0.3	0.1
Mother’s age at death	1.1	1.4	3.8	2.0	-1.2	0.6	-0.0	0.2	1.6
Financial situation satisfaction	0.3	0.4	1.2	-0.6	0.4	0.6	-0.2	-0.2	1.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.0	0.4	0.6	1.0	-0.8	-0.8	0.9
Commuting to job workplace: Public transport	0.7	0.8	2.6	0.0	0.4	-0.2	1.6	1.5	0.2
Eye problems/disorders: Glaucoma	0.9	1.1	2.6	-0.7	0.2	-1.6	0.9	1.0	-1.4
Medication: Blood pressure	0.1	0.1	0.6	-0.1	-0.3	-0.8	-0.0	-0.0	-0.3
Pain type(s) experienced in last month: Hip pain	1.4	1.7	6.1	0.5	-0.0	2.5	0.6	0.7	1.8
Supplements: Fish oil (including cod liver oil)	2.1	2.7	4.7	1.7	0.6	1.3	-1.9	-1.8	2.2
High cholesterol (Self-reported)	0.2	0.3	0.5	-0.6	0.0	-0.0	0.7	0.6	-0.6
Medication: Bendroflumethiazide	0.4	0.7	1.6	-1.2	-0.5	-0.3	-0.5	-0.5	-1.3
Medication: Paracetamol	0.5	0.8	3.3	-1.8	-0.2	0.4	0.8	0.8	0.2
Medication: Lisinopril	0.3	0.4	1.2	1.1	0.3	0.4	0.8	0.8	-0.3
Medication: Atorvastatin	0.3	0.3	1.5	0.1	-0.3	0.1	-0.5	-0.3	-1.2
Illnesses of father: High blood pressure	1.7	2.1	4.0	1.2	1.9	2.0	-1.0	-1.0	1.3
Alcohol drinker status: Never	3.1	3.7	6.2	-1.0	-2.4	-1.2	2.4	2.5	-1.5
Ever smoked	1.6	2.8	7.2	1.1	2.7	0.8	1.7	1.7	1.5
Basal metabolic rate	1.2	6.7	14.9	-1.3	-2.3	-1.5	3.9	3.9	-1.1
Leg fat percentage (left)	1.6	5.9	12.5	-1.9	-1.6	-1.5	3.4	3.5	-1.7
Arm fat-free mass (left)	1.8	9.1	19.3	-1.7	-2.5	-2.0	4.4	4.4	-1.6
Number of operations (self-reported)	0.4	0.6	1.6	0.7	1.2	0.6	-0.1	-0.1	1.3
Average weekly beer plus cider intake	0.8	1.2	3.4	1.6	-0.9	-0.3	0.0	0.0	1.9
Irritability	0.1	0.1	0.6	-0.8	0.2	0.1	0.3	0.2	0.1
Risk taking	0.2	0.3	1.2	0.6	-0.3	-1.1	0.5	0.5	-0.0
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	0.3	0.3	-0.0	-0.7	-0.6	-0.3
Fractured/broken bones in last 5 years	1.2	1.5	2.3	-0.3	-1.3	-1.5	1.4	1.5	-1.0
Age started oral contraceptive pill	1.3	1.6	4.4	-0.3	-1.2	-1.9	-0.2	-0.1	-2.1
Diastolic blood pressure, automated reading	2.4	7.3	20.1	1.2	1.4	0.1	-4.4	-4.5	-1.0
Ever depressed for a whole week	0.8	1.0	2.1	0.6	-0.3	0.7	-1.3	-1.2	1.4
Unable to work because of sickness or disability	2.6	3.4	9.5	-0.0	-0.1	-0.2	3.1	3.0	1.2
Commuting to job workplace: Cycle	1.5	1.8	2.4	1.5	0.7	1.2	-1.5	-1.4	1.6
Myopia	0.5	0.8	1.9	1.4	1.4	0.2	0.0	0.2	0.9
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.3	-0.5	0.4	0.5	0.6	0.8
Cholesterol lowering medication	0.6	0.8	3.2	-0.4	-0.7	-1.8	0.2	0.3	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.9	0.0	-0.6	-1.7	1.3	1.4	-1.1
Pain experienced in last month	0.2	0.4	0.8	0.6	0.2	0.7	0.9	0.8	0.3
Supplements: Calcium	0.3	0.3	1.0	-0.1	1.0	0.4	-0.4	-0.2	0.8
Basal cell carcinoma (self-reported)	0.9	1.1	2.2	-0.3	1.5	1.0	-1.3	-1.3	0.1
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.1	1.0	-0.7	-0.5	1.8	1.7	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	2.4	0.9	-0.9	1.1	0.5	0.5	1.6
Heart disease (siblings)	0.3	0.3	0.9	-0.6	-0.4	-0.6	0.2	0.3	-1.0
Alcohol drinker status: Previous	0.6	0.7	2.1	0.9	-1.4	0.1	0.5	0.4	1.0
Pack years of smoking	0.5	0.8	2.4	-0.3	-0.9	-1.6	0.6	0.6	-0.8
Impedance of whole body	1.1	5.4	14.0	-0.4	2.2	-0.2	-3.7	-3.6	0.1
Leg fat mass (left)	2.0	7.7	16.1	-2.2	-1.6	-1.7	3.9	4.0	-2.0
Arm predicted mass (left)	1.5	7.8	17.1	-1.3	-2.1	-1.9	4.1	4.1	-1.6