TWAS hub - GNB4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.062	0.0290	8.6e-03	0.028	0.019	0.034	0.023	0.034	2.0e-04	0.0018	5.3e-05	0.00063	4.3e-05
2	GTEx	Artery Aorta	0.163	0.0640	1.8e-03	0.022	NA	0.065	NA	0.048	2.2e-02	NA	1.8e-04	NA	1.2e-03
3	GTEx	Esophagus Mucosa	0.116	0.0490	3.6e-03	0.001	NA	0.030	NA	0.011	2.8e-01	NA	4.1e-03	NA	5.4e-02
4	GTEx	Heart Atrial Appendage	0.560	0.0680	2.3e-11	0.453	NA	0.330	NA	0.423	2.0e-22	NA	1.7e-15	NA	1.3e-20
5	GTEx	Heart Left Ventricle	0.451	0.0733	6.1e-10	0.284	NA	0.328	NA	0.347	1.9e-15	NA	4.7e-18	NA	3.0e-19
6	TCGA	Lung Adenocarcinoma	0.062	0.0346	1.3e-03	0.011	0.018	0.016	NA	0.013	1.6e-02	0.0032	4.9e-03	NA	1.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Pulse rate, automated reading	11.8	38.0	106.1	1.8	3.3	0.6	-10.2	-10.3	-1.9
Pulse rate	4.4	7.5	21.5	1.8	0.4	0.2	-4.5	-4.6	-0.3
Number of full brothers	4.1	5.2	12.3	2.0	1.0	3.0	-1.5	-1.6	3.5
Alcohol drinker status: Never	3.1	3.7	6.2	-1.0	-2.4	-1.2	2.4	2.5	-1.5
Unable to work because of sickness or disability	2.6	3.4	9.5	-0.0	-0.1	-0.2	3.1	3.0	1.2
Diabetes (mother)	2.5	3.1	4.8	0.5	-1.8	-1.6	2.2	2.1	-1.9
Diastolic blood pressure, automated reading	2.4	7.3	20.1	1.2	1.4	0.1	-4.4	-4.5	-1.0
Worry too long after embarrassment	2.3	3.9	6.1	2.5	0.6	1.6	-2.2	-2.2	2.2
Eye problems/disorders: None of the above	2.3	2.7	6.1	0.7	0.9	2.5	-1.4	-1.5	2.1
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	6.2	-0.6	-2.5	-2.3	1.1	0.9	-1.3
Arm fat mass (right)	2.2	9.1	19.8	-1.8	-2.1	-2.4	4.4	4.5	-1.6
Neck or shoulder pain in last month	2.2	3.2	5.1	0.5	2.2	0.7	-2.3	-2.3	1.8
Leg pain on walking	2.2	2.8	6.8	-1.0	-0.3	-2.6	1.4	1.6	-2.0
Arm fat mass (left)	2.2	9.2	19.2	-1.8	-2.0	-2.6	4.3	4.4	-1.8
Smoking status: Previous	2.1	3.1	8.5	-1.0	-0.2	-0.0	2.8	2.9	0.9
Supplements: Fish oil (including cod liver oil)	2.1	2.7	4.7	1.7	0.6	1.3	-1.9	-1.8	2.2
Leg fat mass (right)	2.0	7.9	16.2	-2.2	-1.7	-1.7	4.0	4.0	-2.2
Leg fat mass (left)	2.0	7.7	16.1	-2.2	-1.6	-1.7	3.9	4.0	-2.0
Body mass index (BMI)	1.9	8.3	19.7	-1.4	-1.9	-1.6	4.4	4.4	-1.4
Leg fat percentage (right)	1.9	6.9	13.3	-1.9	-2.0	-1.8	3.6	3.6	-2.0
Heart disease (mother)	1.9	2.4	6.5	-0.8	-2.5	-0.3	1.8	1.9	-0.1
Loneliness, isolation	1.9	2.6	4.5	-0.0	-2.1	-1.4	2.0	2.0	-0.9
Current tobacco smoking	1.8	3.0	8.8	1.9	3.0	-0.5	-1.6	-1.6	-0.6
Trunk fat mass	1.8	7.8	14.5	-2.5	-1.6	-2.6	3.7	3.8	-1.9
Pulse wave reflection index	1.8	2.2	4.7	-0.8	-0.0	-1.5	2.1	2.2	-1.2
Ever highly irritable/argumentative for 2 days	1.8	2.1	3.4	1.8	0.9	-0.9	-1.8	-1.8	-1.1
Whole body fat mass	1.8	7.6	15.2	-2.2	-1.7	-2.2	3.8	3.9	-1.8
Ever had bowel cancer screening	1.8	2.1	4.7	0.6	-0.9	-1.4	2.2	2.1	0.6
Eye problems/disorders: Cataract	1.8	2.1	4.7	0.4	-1.8	-2.2	0.7	0.8	-1.8
Mineral and other dietary supplements	1.8	2.4	4.7	-2.1	-0.8	-0.5	1.6	1.4	-2.2
Arm fat-free mass (left)	1.8	9.1	19.3	-1.7	-2.5	-2.0	4.4	4.4	-1.6
Angina	1.7	2.2	5.0	-0.0	-1.2	-1.7	1.5	1.4	-2.2
Waist circumference	1.7	6.4	16.1	-1.2	-1.0	-1.7	3.9	4.0	-1.2
Had menopause	1.7	2.1	6.1	-0.6	-1.2	-2.5	1.1	1.1	-1.6
Weight	1.7	8.6	18.6	-1.8	-2.1	-2.1	4.3	4.3	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	5.6	-2.2	2.4	1.1	-0.7	-0.7	0.7
Supplements: Vitamin C	1.7	2.0	3.4	1.0	1.6	1.9	-1.5	-1.5	0.9
Illnesses of father: High blood pressure	1.7	2.1	4.0	1.2	1.9	2.0	-1.0	-1.0	1.3
Breast Cancer	1.6	3.9	8.0	2.4	2.8	0.7	-2.1	-2.1	0.7
Prostate Cancer	1.6	2.2	5.0	-2.2	2.2	-0.2	1.2	1.3	-0.6
Trunk fat percentage	1.6	6.5	10.7	-2.2	-1.3	-2.9	3.2	3.3	-1.9
Arm fat percentage (right)	1.6	6.3	14.1	-1.4	-1.8	-2.0	3.7	3.8	-1.1
Falls in the last year	1.6	2.1	4.3	0.3	-0.9	-1.9	1.9	2.1	-0.0
Glaucoma (self-reported)	1.6	1.9	4.0	-1.6	0.6	-1.4	1.0	1.2	-2.0
Body fat percentage	1.6	6.2	11.5	-2.0	-1.4	-2.4	3.3	3.4	-1.9
Shortness of breath walking on level ground	1.6	1.9	5.3	-0.1	0.1	0.7	2.3	2.3	-0.0
Angina (self-reported)	1.6	2.1	4.6	-0.0	-1.0	-1.6	1.5	1.4	-2.1
Arm fat percentage (left)	1.6	6.3	13.0	-1.6	-1.8	-2.2	3.5	3.6	-1.3
Smoking status: Current	1.6	2.5	7.1	1.7	2.7	-0.8	-1.3	-1.3	-0.8
Ever smoked	1.6	2.8	7.2	1.1	2.7	0.8	1.7	1.7	1.5
Leg fat percentage (left)	1.6	5.9	12.5	-1.9	-1.6	-1.5	3.4	3.5	-1.7
Bipolar Disorder (2018)	1.5	2.4	5.7	-0.2	-2.4	-1.6	1.8	1.6	-0.4
Bipolar Disorder (2011)	1.5	1.4	3.2	0.4	-0.6	0.4	1.8	1.7	1.3
Coronary Artery Disease (CAD)	1.5	1.8	3.2	1.2	-1.8	-0.2	1.8	1.7	0.6
Had major operations	1.5	1.7	3.6	0.0	1.8	1.9	-0.1	-0.2	1.9
Commuting to job workplace: Cycle	1.5	1.8	2.4	1.5	0.7	1.2	-1.5	-1.4	1.6
Arm predicted mass (left)	1.5	7.8	17.1	-1.3	-2.1	-1.9	4.1	4.1	-1.6
Fasting Glucose	1.4	1.7	3.8	2.0	-1.8	-1.4	0.2	0.4	-0.8
Average weekly spirits intake	1.4	1.8	4.9	2.2	-0.8	1.1	-0.4	-0.3	1.9
Past tobacco smoking	1.4	2.6	6.2	-0.7	-1.1	0.0	-2.4	-2.5	-1.3
Arm fat-free mass (right)	1.4	7.0	14.7	-1.8	-2.0	-1.7	3.8	3.8	-1.7
Mouth/teeth dental problems: Loose teeth	1.4	1.7	4.1	1.7	-0.0	2.0	-0.7	-0.8	1.5
Medication: Aspirin	1.4	1.8	4.0	-0.9	-1.2	-0.9	1.9	2.0	-0.2
Pain type(s) experienced in last month: Hip pain	1.4	1.7	6.1	0.5	-0.0	2.5	0.6	0.7	1.8
Chronotype (morning person)	1.3	3.0	8.4	0.1	-1.6	-2.9	1.1	1.0	-2.2
Hearing difficulty/problems with background noise	1.3	2.0	7.0	2.6	-0.5	0.6	-0.8	-0.8	1.8
Had other major operations	1.3	1.6	3.4	0.6	1.5	-0.1	-1.8	-1.7	-0.4
Financial difficulties in last 2 years	1.3	1.8	3.8	-1.9	1.6	-1.1	0.4	0.4	-1.7
Birth weight of first child	1.3	2.4	10.4	-3.2	-1.2	-0.6	0.3	0.2	-1.4
Arm predicted mass (right)	1.3	6.5	13.8	-1.7	-2.0	-1.5	3.7	3.7	-1.6
Breast cancer (self-reported)	1.3	1.6	3.6	-0.4	-1.1	-1.1	1.8	1.9	-0.2
Age started oral contraceptive pill	1.3	1.6	4.4	-0.3	-1.2	-1.9	-0.2	-0.1	-2.1
Maternal smoking around birth	1.2	1.7	4.0	-0.4	0.5	-1.7	-1.1	-1.3	-2.0
Supplements: Glucosamine	1.2	1.6	2.8	0.5	1.7	1.2	-1.3	-1.3	1.3
Nervous feelings	1.2	2.2	4.9	2.2	-1.3	0.6	1.3	1.3	1.8
Impedance of arm (right)	1.2	5.6	15.0	0.6	1.8	0.2	-3.9	-3.8	1.0
Impedance of arm (left)	1.2	5.7	15.7	0.4	1.6	-0.3	-4.0	-3.9	0.8
Medication: Aspirin	1.2	1.5	3.2	-1.0	-1.4	-0.5	1.7	1.8	0.0
Basal metabolic rate	1.2	6.7	14.9	-1.3	-2.3	-1.5	3.9	3.9	-1.1
Fractured/broken bones in last 5 years	1.2	1.5	2.3	-0.3	-1.3	-1.5	1.4	1.5	-1.0
Depressed Affect (Nagel 2018)	1.1	2.4	3.8	-1.6	-2.0	-1.5	1.6	1.6	-0.4
Depression (Nagel 2018)	1.1	1.7	6.9	-2.6	0.9	-0.6	-0.3	-0.3	-1.3
Major Depression (MDD)	1.1	1.3	2.2	-1.4	-0.6	0.3	1.5	1.5	-1.1
Ever had hysterectomy (womb removed)	1.1	1.2	2.4	-0.7	-0.3	-0.9	1.5	1.6	-1.0
Serious illness, injury or assault to yourself	1.1	1.4	5.2	-1.0	2.3	-0.8	0.7	0.6	-0.7
Heart attack	1.1	1.4	3.6	0.8	-0.8	-0.5	1.9	1.8	-0.0
Hip circumference	1.1	4.9	13.8	-0.8	-1.0	-1.0	3.6	3.7	-0.0
Prospective memory result	1.1	1.4	3.2	0.3	-1.8	-1.7	0.5	0.4	-1.2
Diabetes diagnosed by doctor	1.1	1.7	4.5	0.2	-1.1	-0.6	2.1	2.1	0.4
Commuting to job workplace: Walk	1.1	1.2	4.0	2.0	-0.9	0.0	0.1	0.1	1.5
Guilty feelings	1.1	1.6	4.1	-0.2	-2.0	-0.5	1.5	1.4	1.1
Mother’s age at death	1.1	1.4	3.8	2.0	-1.2	0.6	-0.0	0.2	1.6
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.9	0.0	-0.6	-1.7	1.3	1.4	-1.1
Impedance of whole body	1.1	5.4	14.0	-0.4	2.2	-0.2	-3.7	-3.6	0.1
Crohns Disease (2012)	1.0	1.6	3.0	-1.0	1.5	1.6	0.7	0.6	1.7
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.1	-0.7	-0.8	-0.4	1.3	1.4	1.4
BMI	1.0	6.0	12.0	-2.4	-1.1	-1.7	3.4	3.5	-1.6
Allergy or Eczema	1.0	2.6	4.5	1.8	0.9	0.6	-2.1	-2.1	1.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.2	0.4	-0.8	-1.8	0.8	0.9	-1.1
Time employed in main current job	1.0	1.1	2.6	1.2	-0.9	-0.3	0.9	1.0	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.4	0.6	1.6	-0.3	-1.7	-1.9	-0.5
Medication: Lansoprazole	1.0	1.2	2.4	0.2	-0.9	-1.6	1.2	1.3	-0.7
Breastfed as a baby	1.0	1.3	2.8	-0.3	-1.4	0.0	1.7	1.7	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.4	3.6	-0.8	-0.6	0.2	1.8	1.9	0.6
Mean time to correctly identify matches	1.0	1.8	3.8	-0.6	-1.7	0.1	1.9	1.9	0.6
Suffer from ‘nerves’	1.0	1.5	5.2	2.3	-0.7	0.3	0.5	0.4	1.7
Knee pain experienced in last month	1.0	1.6	2.7	0.9	-1.6	-0.0	1.6	1.6	0.8
Whole body fat-free mass	1.0	5.5	12.5	-0.9	-2.1	-1.3	3.5	3.5	-0.9
Whole body water mass	1.0	5.7	13.3	-0.9	-2.2	-1.3	3.6	3.6	-0.8
Miserableness	1.0	1.7	2.5	-1.5	-1.5	-0.7	1.6	1.5	0.2
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.1	1.0	-0.7	-0.5	1.8	1.7	-0.2
Reaction Time	0.9	1.7	3.3	-0.9	-1.8	-0.5	1.8	1.7	0.3
HbA1C	0.9	1.0	2.7	1.3	-1.6	-1.1	0.2	0.2	0.2
Medication for hormone replacement therapy	0.9	1.0	2.0	-1.0	1.2	1.4	-0.8	-0.9	0.1
Vitamin and mineral supplements	0.9	1.2	2.0	-0.6	-1.3	-1.0	1.3	1.4	-0.2
Leg fat-free mass (left)	0.9	4.5	9.6	-0.7	-2.2	-1.5	3.1	3.0	-0.9
Leg predicted mass (left)	0.9	4.5	9.4	-0.7	-2.3	-1.5	3.1	3.0	-0.9
Medication: Simvastatin	0.9	1.3	2.2	-0.4	-0.5	-1.5	1.5	1.5	-0.9
Trunk fat-free mass	0.9	5.2	12.3	-1.0	-2.0	-0.9	3.5	3.5	-0.7
Mouth/teeth dental problems: Dentures	0.9	1.5	6.8	2.6	-1.0	-1.0	-0.2	-0.3	0.3
Trunk predicted mass	0.9	5.1	12.0	-1.0	-2.1	-0.9	3.5	3.5	-0.7
Blood clot in the leg (DVT)	0.9	1.1	2.8	1.1	-1.1	1.0	0.5	0.5	1.7
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	5.3	-0.2	-0.4	0.2	2.3	2.3	-0.1
Birth weight	0.9	2.0	7.7	-2.8	-0.6	-1.2	0.3	0.3	-1.5
Medication: Ibuprofen	0.9	1.1	2.8	-1.7	1.6	0.9	-0.3	-0.2	0.6
Long-standing illness, disability or infirmity	0.9	1.3	4.1	-0.1	0.2	-0.3	1.9	2.0	0.4
Ever taken oral contraceptive pill	0.9	1.0	1.4	0.7	1.0	1.0	-1.2	-1.2	0.9
Eye problems/disorders: Glaucoma	0.9	1.1	2.6	-0.7	0.2	-1.6	0.9	1.0	-1.4
Basal cell carcinoma (self-reported)	0.9	1.1	2.2	-0.3	1.5	1.0	-1.3	-1.3	0.1
Lupus	0.8	1.1	3.6	0.1	-0.5	-1.9	0.7	0.7	-1.4
Number of treatments/medications taken	0.8	1.4	3.5	-0.8	-0.6	-0.8	1.9	1.9	-0.2
Supplements: Zinc	0.8	0.9	3.0	1.7	-0.2	0.3	0.6	0.8	1.1
Medication: Metformin	0.8	1.1	2.2	-0.4	-1.4	-0.2	1.5	1.5	0.5
Diabetes (father)	0.8	1.0	4.0	2.0	-1.1	-0.7	0.2	0.2	-0.7
Diabetes (self-reported)	0.8	1.2	3.1	0.5	-0.3	-0.8	1.8	1.7	0.4
Hair/balding pattern: Pattern 4	0.8	1.9	5.6	2.4	0.3	0.8	0.0	0.0	2.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.1	-0.0	0.5	1.3	-1.4	-1.3	1.4
Wheeze or whistling in the chest in last year	0.8	1.4	3.8	-1.9	1.1	-0.1	-0.8	-0.8	-1.4
Overall health rating	0.8	1.6	2.8	-0.6	-0.5	-1.6	1.6	1.7	-1.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	5.5	-0.6	-2.3	-0.2	-0.2	-0.0	-0.4
Illnesses of father: Heart disease	0.8	1.1	2.4	-0.2	-1.2	-0.1	1.5	1.5	0.6
Friendships satisfaction	0.8	1.0	3.6	0.5	0.4	1.3	-0.4	-0.5	1.9
Wears glasses or contact lenses	0.8	0.9	1.4	0.1	1.2	0.5	1.2	1.2	1.0
Average weekly beer plus cider intake	0.8	1.2	3.4	1.6	-0.9	-0.3	0.0	0.0	1.9
Ever depressed for a whole week	0.8	1.0	2.1	0.6	-0.3	0.7	-1.3	-1.2	1.4
Alzheimer’s Disease (in mother)	0.7	0.8	2.6	0.4	-1.6	-0.9	0.7	0.7	0.4
Body Mass Index (BMI) (2010)	0.7	1.0	3.2	-0.2	0.6	1.8	-0.6	-0.5	1.3
Primary Biliary Cirrhosis	0.7	1.0	2.4	1.2	-1.1	-1.5	0.5	0.5	-0.7
Cardiovascular Disease	0.7	2.2	5.3	0.9	0.9	1.1	-2.2	-2.3	0.1
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.9	-1.7	-1.1	-1.1	0.3	0.2	-0.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.8	-0.7	-0.0	-0.2	1.3	1.3	0.7
Hayfever, allergic rhinitis or eczema	0.7	1.6	4.2	0.8	0.7	-0.0	-2.0	-2.0	0.6
Medication: Atenolol	0.7	0.9	2.3	0.8	-1.0	-1.5	-0.1	-0.2	-1.2
Chronic bronchitis/emphysema (father)	0.7	0.8	1.4	0.6	0.8	-0.9	-1.2	-1.1	-0.6
High blood pressure (mother)	0.7	1.0	2.2	-1.0	0.0	1.5	-0.9	-0.7	1.2
Health satisfaction	0.7	0.9	2.1	-0.4	1.0	-1.4	1.1	1.1	-0.2
Medication for pain relief, constipation, heartburn	0.7	1.3	2.5	1.6	-0.1	0.8	-1.5	-1.5	0.4
Family relationship satisfaction	0.7	0.8	2.0	-0.7	0.1	-0.3	-1.4	-1.4	-0.6
Leg fat-free mass (right)	0.7	3.5	7.9	-0.4	-1.8	-1.2	2.8	2.8	-0.6
Average weekly red wine intake	0.7	1.0	5.5	2.3	0.4	-0.7	-0.0	-0.1	0.3
Mood swings	0.7	1.3	3.3	-1.8	-1.5	-0.8	0.8	0.8	-0.6
Leg predicted mass (right)	0.7	3.6	8.0	-0.5	-1.9	-1.2	2.8	2.8	-0.6
Commuting to job workplace: Public transport	0.7	0.8	2.6	0.0	0.4	-0.2	1.6	1.5	0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	2.4	0.9	-0.9	1.1	0.5	0.5	1.6
HDL Cholesterol	0.6	0.9	1.9	0.1	-0.4	-0.7	-1.3	-1.4	-1.1
Smoking Status	0.6	1.4	6.8	0.8	2.6	-0.7	-0.1	-0.0	-0.6
Hand grip strength (left)	0.6	1.5	3.9	1.5	-0.7	1.6	0.0	0.0	2.0
Townsend deprivation index at recruitment	0.6	0.8	1.6	1.3	-0.9	-0.8	0.3	0.5	1.1
Fed-up feelings	0.6	1.0	3.7	-0.3	-1.9	-1.1	0.6	0.6	-0.5
Relative age voice broke	0.6	0.9	2.2	0.7	1.5	0.3	-0.4	-0.3	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	4.5	-0.1	-2.1	-0.3	0.8	0.8	-0.1
Hair/balding pattern: Pattern 2	0.6	0.8	2.0	0.4	0.8	0.1	-1.2	-1.4	-0.6
Alcohol intake versus 10 years previously	0.6	0.9	1.6	0.9	1.3	0.5	-1.0	-1.0	0.6
Happiness	0.6	0.7	2.1	-0.4	-1.4	-0.3	1.1	1.0	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	3.0	1.7	-0.4	0.5	0.3	0.1	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	2.9	-1.4	-1.4	-0.3	1.7	1.6	1.1
Pulse wave Arterial Stiffness index	0.6	0.7	1.1	-0.7	-0.6	-0.5	1.0	1.0	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.7	-1.3	-1.0	-0.3	1.0	0.9	-1.0
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.7	-0.6	0.7	-1.0	1.3	1.3	-0.9
Gout (self-reported)	0.6	0.8	1.7	-0.9	0.4	0.2	1.3	1.3	0.8
Medication: Omeprazole	0.6	0.7	1.2	0.2	0.1	-1.1	1.0	1.1	-0.8
Number of full sisters	0.6	0.7	1.6	0.9	0.2	0.2	-1.2	-1.3	0.2
Qualifications: nursing, teaching	0.6	1.0	1.5	-0.2	-1.2	-1.0	1.0	1.0	-1.2
Osteoporosis (self-reported)	0.6	0.8	4.0	0.5	0.0	-2.0	0.1	0.1	-0.7
Osteoarthritis (self-reported)	0.6	0.8	2.3	1.5	-0.4	-0.7	1.0	0.9	0.4
Cholesterol lowering medication	0.6	0.8	3.2	-0.4	-0.7	-1.8	0.2	0.3	-1.0
Alcohol drinker status: Previous	0.6	0.7	2.1	0.9	-1.4	0.1	0.5	0.4	1.0
Worry (Nagel 2018)	0.5	1.1	3.5	1.2	-1.2	-0.3	0.2	0.3	1.9
Crohns Disease (2017)	0.5	1.1	4.0	0.2	2.0	-0.6	0.7	0.7	1.0
Mean Putamen Volume	0.5	0.5	2.2	1.0	-0.1	0.1	-0.2	-0.2	1.5
Neuroticism (2016)	0.5	0.7	1.6	1.2	1.1	-0.7	-0.6	-0.6	-0.2
Systolic Blood Pressure	0.5	2.4	5.2	1.0	1.5	0.9	-2.3	-2.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.0	-0.6	-1.0	-0.7	0.9	0.9	-0.5
Systolic blood pressure, automated reading	0.5	1.4	1.9	1.3	0.3	-1.4	-1.4	-1.3	-1.1
Hand grip strength (right)	0.5	1.4	2.9	1.7	-1.5	0.4	-0.7	-0.6	1.5
Impedance of leg (left)	0.5	2.5	5.3	-1.3	1.7	0.3	-2.3	-2.2	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.9	-0.5	0.9	0.3	-1.7	-1.7	-0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.9	0.9	-1.4	-0.4	0.3	0.3	0.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.6	0.2	-1.3	-1.2	-0.7	-0.6	-0.1
Number of live births	0.5	0.7	1.6	1.0	0.4	-0.4	0.7	0.8	1.2
Lung cancer (father)	0.5	0.6	2.8	1.7	0.3	-0.5	-0.3	-0.3	0.3
Medication: Paracetamol	0.5	0.8	4.2	-2.0	-0.2	-0.2	0.3	0.4	-0.3
Headache pain in last month	0.5	0.8	4.3	-2.1	-0.5	0.3	0.3	0.2	-0.2
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.1	0.1	-1.0	-0.7	0.9	0.9	0.3
High blood pressure (siblings)	0.5	0.8	2.6	0.0	0.9	1.6	-0.7	-0.7	0.6
Forced vital capacity (FVC), Best measure	0.5	2.0	3.7	-0.6	-1.6	-1.1	1.9	1.9	0.7
Number of children fathered	0.5	0.5	2.4	0.5	0.1	-0.7	-0.1	-0.1	-1.6
Qualifications: College or University degree	0.5	1.6	2.4	-0.8	-1.1	-1.4	1.5	1.6	-1.0
Emphysema/chronic bronchitis	0.5	0.6	1.0	-0.1	-0.3	-1.0	1.0	0.9	-0.9
Medication: Blood pressure	0.5	0.9	1.6	-0.1	-0.1	-1.1	1.1	1.0	-1.3
Migraine (self-reported)	0.5	0.6	1.4	1.2	-0.8	-1.1	0.4	0.4	0.6
Medication: Allopurinol	0.5	0.6	1.3	-0.1	0.4	0.8	1.1	1.1	0.7
Alcohol intake frequency.	0.5	1.2	2.5	1.0	-1.6	1.3	0.0	-0.0	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.6	0.8	-0.2	-0.2	-1.2	-1.2	0.0
Illnesses of siblings: Diabetes	0.5	0.6	2.5	1.6	-0.6	-0.9	-0.1	-0.1	0.1
Medication for cholesterol	0.5	0.7	1.9	1.4	-0.3	0.3	0.7	0.7	1.0
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.0	0.4	0.6	1.0	-0.8	-0.8	0.9
Medication: Paracetamol	0.5	0.8	3.3	-1.8	-0.2	0.4	0.8	0.8	0.2
Myopia	0.5	0.8	1.9	1.4	1.4	0.2	0.0	0.2	0.9
Pack years of smoking	0.5	0.8	2.4	-0.3	-0.9	-1.6	0.6	0.6	-0.8
Bipolar Disorder or Schizophrenia	0.4	0.9	2.3	0.5	-1.5	-1.4	0.8	0.7	0.2
Neuroticism (Nagel 2018)	0.4	0.8	2.6	0.0	-1.6	-1.0	0.7	0.7	0.7
Schizophrenia vs Biploar Disorder	0.4	0.6	1.4	0.2	-0.4	0.6	-1.2	-1.2	0.1
LDL Cholesterol	0.4	0.7	1.6	0.5	0.9	0.1	-1.1	-1.3	-0.4
Blood White Count	0.4	2.7	8.5	-1.9	1.9	-0.5	-0.2	-0.1	-2.9
Waist Hip Ratio (WHR)	0.4	1.9	5.2	-2.3	-0.0	-1.0	0.7	0.7	-2.0
Relative age of first facial hair	0.4	0.7	1.8	1.3	1.4	0.4	-0.1	-0.1	0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.8	0.7	0.3	-0.9	0.8	0.9	-0.5
Impedance of leg (right)	0.4	2.1	4.6	-1.3	1.1	-0.1	-2.1	-2.1	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	2.0	-1.4	0.9	-0.3	0.1	-0.0	-0.7
Stomach or abdominal pain in last month	0.4	0.5	1.2	-0.1	-0.9	-1.1	0.0	-0.1	-0.9
Alcohol usually taken with meals	0.4	0.7	2.5	-0.0	0.5	1.6	-0.8	-0.9	-0.0
Qualifications: None of the above	0.4	0.9	1.9	1.4	-1.3	0.3	-0.7	-0.7	0.9
Mouth/teeth dental problems	0.4	0.6	1.8	-1.3	0.9	-0.3	-0.2	0.1	-1.0
Allergy	0.4	0.9	2.3	-0.3	-0.8	-0.4	1.5	1.5	-0.6
Pain all over the body in last month	0.4	0.5	1.0	0.9	-0.1	-1.0	0.5	0.5	-0.7
Medication: Ramipril	0.4	0.5	1.3	1.1	0.7	-0.7	0.4	0.4	-0.4
Worrier / anxious feelings	0.4	0.8	2.8	0.5	-1.7	-1.3	-0.2	-0.2	0.0
Hair/balding pattern: Pattern 3	0.4	0.6	2.2	-1.5	0.7	0.5	0.4	0.5	0.4
Noisy workplace	0.4	0.5	1.3	0.9	0.4	-0.4	0.4	0.4	1.2
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.6	-1.0	-1.2	-0.0	1.2	1.2	-0.4
Medication: Cholesterol lowering	0.4	0.6	1.3	-0.5	-0.2	-0.4	1.1	1.1	-0.9
Depression (self-reported)	0.4	0.5	1.5	1.2	0.0	1.1	0.3	0.1	0.6
Length of working week for main job	0.4	0.5	1.1	-0.4	-0.2	-0.3	1.0	1.1	0.7
Tense / ‘highly strung’	0.4	0.6	1.4	-0.0	-0.9	-0.2	-1.1	-1.2	0.3
Pulse wave peak to peak time	0.4	0.5	1.0	0.6	0.5	0.3	-1.0	-1.0	0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	-1.1	0.6	-0.1	-0.4	-0.5	-0.9
Medication: Gliclazide	0.4	0.4	0.7	-0.8	-0.8	0.2	0.7	0.6	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.4	-1.9	-1.1	-0.3	0.6	0.6	0.1
Number of self-reported non-cancer illnesses	0.4	0.6	2.4	0.8	0.2	-1.6	0.6	0.6	-0.2
Medication: Bendroflumethiazide	0.4	0.7	1.6	-1.2	-0.5	-0.3	-0.5	-0.5	-1.3
Number of operations (self-reported)	0.4	0.6	1.6	0.7	1.2	0.6	-0.1	-0.1	1.3
Alzheimer’s Disease (including proxy)	0.3	0.5	0.7	0.8	-0.6	-0.9	0.4	0.4	0.8
Irritable Bowel Disease (IBD)	0.3	0.7	3.1	-0.9	1.8	-0.0	-0.4	-0.5	0.0
Ulcerative Colitis (UC)	0.3	0.6	1.5	-1.2	0.7	0.6	-0.7	-0.8	-0.4
Ulcerative Colitis	0.3	0.5	2.4	-1.6	0.2	0.6	0.3	0.2	-0.4
Blood Platelet Count	0.3	3.4	6.8	-1.3	2.6	-1.3	-1.8	-1.5	-2.2
Hypothyroidism (self reported)	0.3	0.8	1.3	0.2	-1.0	-0.1	1.1	1.1	-1.0
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.6	0.0	-0.3	0.3	1.3	1.2	0.6
Sensitivity / hurt feelings	0.3	0.5	1.1	-0.1	-1.0	-0.0	-0.9	-1.0	0.2
Hearing difficulty/problems: Yes	0.3	0.5	1.6	0.4	0.1	1.0	-0.2	-0.1	1.3
Pack years adult smoking proportion	0.3	0.5	2.0	-0.1	-0.7	-1.4	0.2	0.2	-0.7
Forced vital capacity (FVC)	0.3	1.2	2.2	-0.6	-1.2	-1.1	1.4	1.5	0.2
Illnesses of mother	0.3	0.3	1.0	0.0	0.9	-0.2	0.3	0.2	-1.0
Exposure to tobacco smoke at home	0.3	0.3	0.7	-0.2	-0.0	-0.2	-0.8	-0.8	-0.7
Peak expiratory flow (PEF)	0.3	0.8	2.8	0.7	0.6	0.8	0.3	0.4	1.7
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.0	0.6	1.0	0.0	-0.6	-0.6	0.4
Exposure to tobacco smoke outside home	0.3	0.4	1.5	-0.4	-0.8	-1.2	0.0	-0.0	-0.3
Medication: Seretide 50 evohaler	0.3	0.3	0.8	-0.4	-0.0	0.9	0.3	0.4	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.3	-0.5	0.6	1.1	-0.3	-0.2	0.4
Comparative height size at age 10	0.3	1.6	3.4	-0.5	-1.9	-1.5	1.2	1.3	-0.8
Age at last live birth	0.3	0.4	1.1	1.0	-0.7	0.5	-0.7	-0.7	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.5	0.7	0.5	-0.5	0.5	0.6	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.0	-0.8	-1.0	0.4	-0.4	-0.5	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	0.5	0.9	-0.6	-0.5	-0.7	-0.5
Asthma (self-reported)	0.3	0.7	2.0	-0.8	1.4	0.0	-0.8	-0.6	-0.5
Average weekly champagne plus white wine intake	0.3	0.4	1.3	-1.2	-0.2	0.4	-0.3	-0.4	-0.7
Financial situation satisfaction	0.3	0.4	1.2	-0.6	0.4	0.6	-0.2	-0.2	1.1
Medication: Lisinopril	0.3	0.4	1.2	1.1	0.3	0.4	0.8	0.8	-0.3
Medication: Atorvastatin	0.3	0.3	1.5	0.1	-0.3	0.1	-0.5	-0.3	-1.2
Supplements: Calcium	0.3	0.3	1.0	-0.1	1.0	0.4	-0.4	-0.2	0.8
Heart disease (siblings)	0.3	0.3	0.9	-0.6	-0.4	-0.6	0.2	0.3	-1.0
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.1	0.4	0.6	-0.5	-0.5	0.2
Ovarian Cancer	0.2	0.3	0.9	0.7	-0.9	-0.5	-0.2	-0.3	-0.2
Rheumatoid Arthritis	0.2	0.2	0.5	0.2	0.7	-0.3	0.5	0.3	0.5
Blood Eosinophil Count	0.2	1.8	5.4	-1.1	1.4	-1.1	0.8	0.8	-2.3
Blood Red Count	0.2	1.6	4.5	-0.1	1.6	-2.1	0.7	0.9	-1.1
Respiratory disease	0.2	0.5	1.8	-0.1	1.3	0.2	-0.9	-0.7	0.2
Lung FEV1/FVC ratio	0.2	0.9	2.1	-1.4	-0.1	0.4	1.1	1.1	0.7
Lung FVC	0.2	0.8	2.1	-0.4	-1.4	-0.2	1.2	1.1	0.3
Medication: Co-codamol	0.2	0.2	0.8	-0.3	-0.2	-0.0	0.3	0.3	-0.9
Severe depression (siblings)	0.2	0.3	0.5	0.3	0.6	-0.2	-0.7	-0.7	-0.3
Average weekly fortified wine intake	0.2	0.2	0.8	0.5	-0.0	0.9	-0.4	-0.5	0.0
Taking other prescription medications	0.2	0.4	0.8	0.9	0.2	-0.0	0.7	0.8	0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.9	0.9	-0.3	-0.2	-0.3	-0.5	0.1
Qualifications: CSEs or equivalent	0.2	0.3	0.5	-0.5	0.5	0.7	-0.2	-0.3	0.7
High blood pressure	0.2	0.6	1.2	0.7	0.8	0.4	-1.1	-1.1	0.2
Multivitamins +/- minerals	0.2	0.2	1.1	0.1	1.0	0.1	-0.3	-0.4	0.2
Medication: Levothyroxine sodium	0.2	0.4	0.8	0.4	0.3	0.7	0.9	0.8	0.4
Number of incorrect matches in round	0.2	0.3	1.1	1.0	0.2	0.2	0.0	0.0	0.8
Fluid intelligence score	0.2	0.4	1.0	-0.7	1.0	0.6	-0.4	-0.2	-0.6
Neuroticism score	0.2	0.4	1.1	-0.2	-1.0	0.2	0.2	0.2	1.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.1	-1.0	-0.6	-0.5	1.0	1.0	0.6
Asthma	0.2	0.3	0.8	-0.9	0.8	-0.4	-0.4	-0.2	-0.5
Loud music exposure frequency	0.2	0.2	0.8	-0.9	0.1	0.2	-0.2	-0.2	0.5
Medication: Amlodipine	0.2	0.3	1.0	0.7	0.3	-1.0	-0.1	-0.2	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.9	-0.0	0.9	-0.2	-0.6	-0.4	-0.5
Age at first live birth	0.2	0.4	1.0	-0.8	-0.5	0.4	-0.5	-0.4	-1.0
Chest pain or discomfort	0.2	0.3	0.6	-0.8	-0.1	-0.6	-0.7	-0.7	0.1
Hypertension (Self-reported)	0.2	0.5	1.0	1.0	0.6	0.5	-0.7	-0.7	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.4	-0.2	-1.2	-0.7	-0.5	-0.2	-0.2
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.9	0.5	1.0	0.2	-0.3	-0.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.9	-0.1	1.0	-0.2	-0.2	-0.2	-0.1
Back pain experienced in last month	0.2	0.3	0.7	0.9	-0.5	-0.5	-0.6	-0.6	0.1
Hearing aid user	0.2	0.2	0.6	0.8	0.5	-0.3	-0.4	-0.3	0.1
High cholesterol (Self-reported)	0.2	0.3	0.5	-0.6	0.0	-0.0	0.7	0.6	-0.6
Risk taking	0.2	0.3	1.2	0.6	-0.3	-1.1	0.5	0.5	-0.0
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	0.3	0.3	-0.0	-0.7	-0.6	-0.3
Pain experienced in last month	0.2	0.4	0.8	0.6	0.2	0.7	0.9	0.8	0.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	-0.9	0.7	-0.2	-0.2	-0.1	-0.9
Schizophrenia (2018)	0.1	0.3	0.6	0.8	-0.0	-0.5	-0.4	-0.4	0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.6	0.5	0.2	-0.5	-0.3	-0.2
Age at First Birth	0.1	0.2	0.4	0.7	-0.5	0.2	-0.4	-0.5	0.1
Schizophrenia (2014)	0.1	0.2	0.8	-0.6	-0.3	-0.9	-0.1	-0.1	0.5
Triglycerides	0.1	0.2	0.4	-0.3	0.7	0.2	-0.6	-0.6	0.0
Heel T-Score	0.1	0.5	1.5	1.2	0.7	-0.2	-0.4	-0.4	0.7
Height	0.1	2.2	5.7	-0.9	-1.4	-2.4	0.7	0.7	-2.0
Neuroticism	0.1	0.2	0.7	-0.3	-0.8	-0.3	-0.2	-0.1	0.7
Hair Pigment	0.1	2.4	8.6	1.2	0.2	1.0	1.4	1.2	2.9
Tanning	0.1	1.5	2.8	0.7	1.3	-1.0	-1.7	-1.6	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	-0.5	0.1	-0.0	-0.7	-0.8	-0.5
Father’s age at death	0.1	0.1	0.4	0.0	-0.1	0.6	0.2	0.2	-0.1
Standing height	0.1	0.7	2.2	-1.1	-0.5	-1.5	0.1	0.2	-0.8
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.3	0.4	0.4	0.1	-0.1	-0.5
Comparative body size at age 10	0.1	0.3	0.9	-0.6	-0.4	-0.4	-0.1	0.1	-1.0
Illnesses of father: None of the above (group 1)	0.1	0.2	0.9	-0.9	-0.3	0.1	0.2	0.2	0.2
Medication: Blood pressure	0.1	0.1	0.6	-0.1	-0.3	-0.8	-0.0	-0.0	-0.3
Irritability	0.1	0.1	0.6	-0.8	0.2	0.1	0.3	0.2	0.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.3	-0.5	0.4	0.5	0.6	0.8
Age when periods started (menarche)	0.0	0.1	0.2	-0.3	0.4	-0.5	-0.3	-0.4	0.2
Sitting height	0.0	0.3	0.7	0.9	-0.7	-0.4	0.3	0.2	0.5
Illnesses of siblings	0.0	0.1	0.3	-0.5	0.2	-0.1	-0.0	0.0	-0.1

Hub : Genes

GNB4

Models

Trait associations