Hub : Genes

GOLGA7B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0690	0.0300	0.0055	0.005	0.009	0.039	NA	0.030	7.9e-02	0.0240	1.3e-05	NA	1.3e-04
2	GTEx	Thyroid	0.2190	0.0600	0.0005	0.092	NA	0.051	NA	0.075	1.5e-07	NA	8.4e-05	NA	2.1e-06
3	METSIM	Adipose	0.0796	0.0333	0.0014	0.050	0.014	0.068	0.042	0.057	4.4e-08	0.0025	2.0e-10	5e-07	6.2e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.6	1.5	-0.2	1.2	0.4
Bipolar Disorder or Schizophrenia	0.8	2.0	5.0	0.3	2.2	-0.9
Depressed Affect (Nagel 2018)	1.4	2.9	6.7	0.5	1.3	-2.6
Depression (Nagel 2018)	4.5	6.7	10.4	1.7	3.2	-2.6
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.5	1.1	-1.2	-0.8
Neuroticism (Nagel 2018)	1.3	3.0	7.2	1.1	0.7	-2.7
Schizophrenia (2018)	0.9	1.8	3.5	0.6	1.9	-1.3
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.0	0.4	0.5
Worry (Nagel 2018)	1.2	2.5	3.6	1.7	1.1	-1.9
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	-0.0	0.1	0.3
Alzheimer’s Disease (in father)	2.7	2.9	5.5	-0.9	-2.4	1.5
Alzheimer’s Disease (including proxy)	1.0	1.4	1.8	-0.9	-1.2	1.4
Crohns Disease (2017)	1.1	2.5	4.3	-2.1	0.1	1.8
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	-0.2	-0.2	0.9
Ulcerative Colitis (UC)	0.3	0.5	1.5	1.2	-0.2	-0.1
Major Depression (MDD)	0.3	0.4	0.5	-0.7	0.5	0.7
Reaction Time	0.8	1.6	2.9	-0.7	1.2	-1.7
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.0	1.6	0.1	-1.7
Breast Cancer	0.1	0.2	0.4	0.1	0.0	-0.7
Ovarian Cancer	0.6	0.8	2.3	-0.2	-0.0	1.5
Prostate Cancer	0.8	1.1	1.8	0.1	-1.2	1.4
Age at First Birth	0.1	0.2	0.4	-0.0	0.6	-0.4
Bipolar Disorder (2011)	0.2	0.2	0.4	0.6	0.2	-0.5
Body Mass Index (BMI) (2010)	0.4	0.5	1.2	-0.6	-1.1	0.1
Coronary Artery Disease (CAD)	0.5	0.6	1.0	-0.7	-1.0	0.4
Crohns Disease (2012)	2.2	3.5	7.2	-2.7	0.4	1.8
Mean Putamen Volume	1.9	2.1	4.6	-0.2	2.1	-1.3
Fasting Glucose	0.5	0.6	1.2	-0.6	-1.1	0.4
HbA1C	0.5	0.6	0.8	0.5	0.8	-0.9
HDL Cholesterol	0.8	1.3	2.0	-0.7	1.4	1.2
LDL Cholesterol	0.9	1.4	2.5	-1.6	0.6	-1.2
Lupus	1.5	2.3	4.2	2.0	-1.3	-1.0
Neuroticism (2016)	0.9	1.2	1.6	1.0	1.1	-1.3
Primary Biliary Cirrhosis	1.2	1.7	2.7	1.6	0.7	1.4
Rheumatoid Arthritis	0.4	0.5	1.3	-0.0	-0.4	1.1
Schizophrenia (2014)	0.4	0.9	2.5	-0.3	1.6	0.2
Triglycerides	0.9	1.5	3.7	-0.7	-0.7	-1.9
Type 2 Diabetes (T2D) (2012)	1.4	1.7	3.4	-1.8	-1.0	0.8
Ulcerative Colitis	0.4	0.5	0.9	-0.9	-0.7	0.6
Blood Eosinophil Count	0.2	1.5	2.3	-0.9	1.1	1.5
Blood Platelet Count	0.2	2.3	3.8	-0.7	1.7	1.9
Blood Red Count	0.2	1.6	2.9	-1.7	1.3	-0.5
Blood White Count	0.2	1.8	2.7	-0.3	1.6	1.6
Heel T-Score	0.1	0.6	1.2	1.1	0.4	0.6
BMI	2.5	14.5	42.2	-6.5	-1.2	0.1
Height	0.1	1.0	2.0	1.4	-0.7	-0.7
Waist Hip Ratio (WHR)	0.0	0.2	0.4	0.6	0.2	0.2
Systolic Blood Pressure	0.5	2.6	6.0	0.3	1.3	-2.5
Smoking Status	0.4	1.0	2.3	-0.9	-0.1	-1.5
Allergy or Eczema	0.3	0.7	2.0	-0.1	1.4	0.1
Cardiovascular Disease	0.3	0.9	1.6	-1.3	-0.7	-0.8
Hypothyroidism (self reported)	0.3	0.8	1.4	-0.4	-1.2	0.9
Respiratory disease	0.7	1.5	3.0	-0.9	-0.7	1.7
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.7	-0.1	-0.8	-0.0
Lung FEV1/FVC ratio	0.0	0.2	0.4	-0.2	0.4	0.6
Lung FVC	1.3	6.6	10.0	3.2	0.8	-3.0
Neuroticism	0.3	0.7	1.3	0.9	-0.4	-1.1
Chronotype (morning person)	0.8	1.9	3.1	0.4	1.8	-1.6
Hair Pigment	0.0	1.0	2.1	-0.6	0.7	1.5
Tanning	0.1	1.0	2.9	-0.2	1.7	-0.2
Hand grip strength (left)	1.9	5.0	6.5	2.5	-1.4	-2.5
Number of treatments/medications taken	2.0	3.7	8.1	-1.4	-1.0	2.9
Average weekly spirits intake	1.6	2.0	5.3	-0.9	2.3	-0.0
Sensitivity / hurt feelings	0.7	1.1	3.2	0.4	-1.8	-0.1
Frequency of depressed mood in last 2 weeks	2.5	3.6	7.5	0.7	1.6	-2.7
Hearing difficulty/problems: Yes	1.5	2.3	3.9	-2.0	-1.6	0.6
Relative age of first facial hair	0.2	0.5	0.9	-0.7	0.2	-1.0
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	3.2	-1.0	1.8	-0.7
Ever used hormone-replacement therapy (HRT)	2.8	3.5	8.0	-2.8	-0.1	1.6
Ever had hysterectomy (womb removed)	2.2	2.5	4.3	-2.1	1.3	1.2
Systolic blood pressure, automated reading	0.8	2.3	4.1	-1.6	2.0	-0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.2	-0.6	0.4
Angina	1.1	1.4	2.5	-1.3	0.2	1.6
Medication for hormone replacement therapy	1.5	1.6	2.4	-1.2	-1.1	1.6
Vitamin and mineral supplements	0.4	0.6	0.9	-0.6	-0.7	-1.0
Supplements: Zinc	1.9	2.1	5.9	2.4	-0.3	-0.4
Medication: Co-codamol	0.8	0.9	1.4	-0.6	1.2	0.9
Medication: Metformin	2.3	3.2	5.0	-2.0	-2.2	0.6
Diabetes (father)	0.4	0.5	1.6	0.0	-0.2	-1.2
Diabetes (mother)	0.4	0.5	1.1	-0.6	-1.1	-0.4
Severe depression (siblings)	0.0	0.0	0.1	0.2	0.2	-0.1
Pack years adult smoking proportion	0.2	0.4	1.0	-1.0	-0.0	-0.2
Impedance of leg (right)	1.1	5.4	12.8	3.6	0.6	1.8
Leg fat-free mass (left)	1.0	5.0	10.2	-3.2	-0.9	-2.0
Trunk fat percentage	2.5	9.9	28.7	-5.4	-0.3	0.9
Hand grip strength (right)	1.8	4.8	10.2	1.9	-0.7	-3.2
Townsend deprivation index at recruitment	0.2	0.3	0.5	-0.7	0.4	0.4
Current tobacco smoking	0.2	0.3	0.6	-0.7	0.4	-0.3
Average weekly fortified wine intake	0.4	0.5	0.6	-0.7	0.6	-0.6
Maternal smoking around birth	0.2	0.2	0.4	-0.5	0.2	-0.6
Fed-up feelings	1.7	3.1	5.7	0.5	1.8	-2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.7	5.9	0.9	2.4	-1.2
Relative age voice broke	0.3	0.4	0.9	0.5	-0.3	-0.9
Taking other prescription medications	1.1	1.8	2.6	-1.6	-0.5	1.6
Age when periods started (menarche)	0.5	1.1	3.3	1.8	-0.2	0.1
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	3.6	-1.9	-0.9	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	3.2	-0.7	-1.0	1.8
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.5	0.3	-1.6	-0.0
Qualifications: CSEs or equivalent	0.7	0.9	2.0	0.6	0.7	-1.4
Serious illness, injury or assault to yourself	0.5	0.6	1.9	-1.4	-0.1	0.0
High blood pressure	0.3	0.7	2.1	-1.5	-0.3	0.0
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.5	0.4	1.2	-0.4
Multivitamins +/- minerals	0.1	0.2	0.3	0.6	0.4	0.1
Stomach or abdominal pain in last month	1.8	2.3	4.4	-2.1	0.5	1.5
Supplements: Glucosamine	0.1	0.2	0.4	0.6	0.5	-0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	0.1	0.9	-0.8
Medication: Atenolol	0.8	1.1	2.8	-1.7	0.5	-0.3
Medication: Levothyroxine sodium	0.4	0.7	0.8	-0.8	-0.7	0.9
Sitting height	0.1	0.9	2.5	-0.5	-0.1	-1.6
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	-0.1	1.0	0.1
High blood pressure (mother)	0.6	0.9	1.3	-1.2	-0.9	-0.7
Body mass index (BMI)	3.2	13.5	40.2	-6.3	-0.1	-0.5
Impedance of leg (left)	1.2	5.9	15.1	3.9	1.1	1.1
Leg predicted mass (left)	1.0	5.2	10.7	-3.3	-0.9	-2.0
Trunk fat mass	2.4	10.4	30.9	-5.6	-0.5	0.2
Waist circumference	2.4	8.8	25.7	-5.1	-0.0	-0.7
Number of incorrect matches in round	1.5	2.5	6.6	-0.6	2.6	0.8
Past tobacco smoking	0.6	1.1	2.8	0.2	0.6	1.7
Alcohol usually taken with meals	1.0	1.6	2.7	-0.9	-1.2	-1.6
Nervous feelings	0.6	1.1	2.9	1.7	0.5	-0.5
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	8.1	0.1	2.9	-1.7
Hearing difficulty/problems with background noise	0.4	0.6	1.6	0.1	0.5	-1.3
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.1	0.5	-1.0
Had menopause	2.1	2.6	6.6	-2.6	0.7	1.0
Had other major operations	0.8	1.0	2.1	-0.6	-0.7	1.4
Forced vital capacity (FVC)	1.8	6.9	12.1	2.9	-0.6	-3.5
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.3	0.4	-0.6	2.1
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.0	1.4	-0.1	-1.4
Qualifications: None of the above	1.4	2.9	4.6	-1.6	2.1	1.3
Financial difficulties in last 2 years	0.3	0.4	0.5	-0.7	0.7	-0.4
Mouth/teeth dental problems	0.1	0.1	0.3	0.3	0.2	0.6
Heart attack	1.1	1.4	3.8	-2.0	-0.5	0.3
Allergy	0.1	0.2	0.3	-0.3	-0.6	-0.4
Pain all over the body in last month	1.0	1.1	2.0	-0.2	1.4	-1.1
Diabetes (self-reported)	0.3	0.5	1.3	-0.3	-0.1	1.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	4.0	0.3	2.0	-0.1
Medication: Ramipril	0.8	1.0	1.9	-1.4	-0.6	-0.9
Medication: Simvastatin	3.2	4.7	5.6	-2.2	-2.0	2.4
Fluid intelligence score	0.9	1.8	5.3	2.3	-0.0	-0.5
Illnesses of siblings	1.4	1.9	2.2	1.5	-1.3	1.3
Neuroticism score	0.2	0.5	1.0	1.0	0.0	-0.7
Weight	1.8	9.1	25.4	-5.0	-0.4	-1.3
Impedance of arm (right)	1.2	5.5	10.7	3.3	-0.8	2.2
Arm fat percentage (right)	3.1	12.4	35.8	-6.0	-0.9	0.8
Trunk fat-free mass	0.6	3.5	6.1	-2.1	-0.2	-2.5
Hip circumference	2.0	8.6	25.6	-5.1	-0.5	-0.0
Time employed in main current job	2.2	2.6	6.3	-1.1	-2.5	0.3
Alcohol intake versus 10 years previously	1.2	1.8	1.9	-1.3	-1.4	1.4
Father’s age at death	0.5	0.6	0.9	-0.4	-0.9	-0.9
Worrier / anxious feelings	0.7	1.2	2.8	1.7	0.5	0.8
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	5.0	0.7	1.1	-2.2
Falls in the last year	3.5	4.7	14.1	0.1	3.8	0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	-0.3	0.8	-0.3
Number of live births	1.7	2.5	4.4	-1.5	-0.9	2.1
Forced expiratory volume in 1-second (FEV1)	1.4	4.9	9.1	2.2	-0.7	-3.0
Pulse rate	0.7	1.3	2.2	-0.3	-1.5	1.2
Happiness	2.4	2.9	5.5	0.1	1.7	-2.4
Noisy workplace	0.1	0.1	0.2	-0.2	0.5	-0.2
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.2	0.3	-1.8	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.0	-0.7	0.2	-1.0
Mouth/teeth dental problems: Dentures	1.2	2.0	4.7	-2.2	1.1	0.3
Asthma	0.7	1.4	2.2	-0.7	-1.2	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.2	-1.5	0.3	-0.2
Medication: Cholesterol lowering	1.5	2.3	2.7	-1.6	-1.3	1.7
Depression (self-reported)	1.0	1.2	3.2	0.2	0.5	-1.8
Medication: Lansoprazole	1.4	1.6	4.1	-2.0	0.1	-0.8
Prospective memory result	0.1	0.1	0.2	0.1	0.2	-0.5
Lung cancer (father)	0.7	0.8	1.4	0.5	1.2	-0.9
Illnesses of mother	0.9	1.1	1.9	-1.4	0.4	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	4.6	1.6	-0.4	-2.2
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.2	-0.4	-0.4
Impedance of arm (left)	1.0	4.8	8.2	2.9	-0.4	2.5
Arm fat mass (right)	2.8	11.6	34.6	-5.9	-0.4	-0.3
Trunk predicted mass	0.6	3.7	6.3	-2.2	-0.1	-2.5
Standing height	0.2	2.5	4.1	2.0	-0.2	-1.8
Length of working week for main job	1.8	2.0	3.4	0.4	1.6	-1.8
Exposure to tobacco smoke at home	0.3	0.3	0.5	0.2	0.5	-0.7
Breastfed as a baby	0.7	0.8	2.4	0.2	1.5	-0.0
Tense / ‘highly strung’	0.6	1.0	2.2	-1.5	0.8	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.2	5.0	-0.6	1.2	-2.2
Hair/balding pattern: Pattern 4	0.7	1.8	2.8	-0.3	-1.7	1.6
Birth weight of first child	0.2	0.4	0.9	0.3	-0.9	-0.4
Peak expiratory flow (PEF)	0.4	1.0	2.3	-0.2	-0.8	-1.5
Pulse wave reflection index	0.1	0.2	0.4	-0.7	0.2	0.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.8	-1.7	-0.4	-0.5
Loud music exposure frequency	2.6	2.9	5.2	-1.1	1.5	-2.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.0	0.4	-0.5	-1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	0.3	-0.9	-0.4
Blood clot in the leg (DVT)	0.3	0.4	0.9	1.0	-0.5	-0.1
Medication: Paracetamol	0.5	0.9	2.2	-0.5	1.5	0.3
Headache pain in last month	0.2	0.3	0.5	-0.7	0.1	0.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.6	3.2	1.8	0.7	-1.0
Glaucoma (self-reported)	0.7	0.9	2.5	1.6	-0.0	-0.2
Gout (self-reported)	0.7	0.9	1.9	-0.6	-1.4	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	-0.0	-1.0	0.6
Medication: Amlodipine	2.4	3.3	7.9	-2.8	1.3	0.6
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.1	-0.8	-1.4	-0.8
Birth weight	0.4	0.8	1.6	0.0	1.3	0.9
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.2	0.9	1.1	0.3
High blood pressure (siblings)	1.7	2.4	3.1	-1.3	1.5	-1.8
Forced vital capacity (FVC), Best measure	1.1	3.9	6.6	2.2	-0.4	-2.6
Body fat percentage	2.9	11.4	33.2	-5.8	-0.3	1.0
Leg fat percentage (right)	2.7	9.7	28.5	-5.3	0.3	0.7
Arm fat-free mass (right)	1.0	5.3	9.8	-3.1	0.3	-2.4
Exposure to tobacco smoke outside home	4.5	6.0	7.9	1.6	2.8	-2.7
Comparative body size at age 10	0.4	1.1	1.8	-1.0	0.6	-1.4
Number of full brothers	1.2	1.5	3.9	0.8	2.0	0.1
Worry too long after embarrassment	1.0	1.6	4.2	2.0	-0.0	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.9	1.0	0.3	-1.4
Wheeze or whistling in the chest in last year	0.7	1.2	3.0	-0.6	1.7	-0.6
Number of children fathered	0.8	1.0	1.5	-1.2	-0.7	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.8	0.3	-0.9	1.4
Age at first live birth	0.5	1.0	2.1	1.5	-0.7	0.5
Pulse wave peak to peak time	0.2	0.2	0.3	0.5	0.5	0.2
Health satisfaction	1.1	1.4	3.8	-2.0	-0.2	-0.6
Shortness of breath walking on level ground	1.8	2.2	4.4	-2.1	-0.5	-1.4
Qualifications: College or University degree	0.7	2.2	4.1	2.0	-1.6	0.1
Eye problems/disorders: None of the above	0.4	0.5	0.7	-0.4	-0.8	-0.8
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.7	0.5	-0.7	-0.9
Emphysema/chronic bronchitis	2.3	2.6	7.7	0.4	2.8	-0.2
Medication for pain relief, constipation, heartburn	0.9	1.6	3.6	1.9	-0.2	-1.1
Neck or shoulder pain in last month	1.2	1.7	4.5	0.7	0.5	-2.1
Medication: Blood pressure	0.3	0.5	0.6	-0.8	-0.7	0.7
Angina (self-reported)	0.7	1.0	1.7	-1.1	0.2	1.3
Migraine (self-reported)	0.9	1.1	3.0	-0.6	-0.0	1.7
Medication: Ibuprofen	0.6	0.7	1.0	-0.8	1.0	-0.6
Medication: Allopurinol	1.0	1.3	3.1	-1.8	-0.9	-0.2
Medication: Omeprazole	1.6	2.0	3.2	-1.8	-0.6	1.5
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.5	-0.5	0.5
Mean time to correctly identify matches	0.6	1.1	1.8	-1.3	1.1	-0.3
Heart disease (mother)	0.4	0.5	1.3	0.4	1.1	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.0	0.9	-0.5	-1.0
Whole body fat mass	2.8	11.8	34.9	-5.9	-0.6	0.3
Leg fat mass (right)	2.9	11.2	33.5	-5.8	-0.3	-0.3
Arm predicted mass (right)	1.0	5.3	9.4	-3.1	0.3	-2.5
Pulse rate, automated reading	0.7	2.4	3.8	-2.0	-1.7	0.7
Alcohol intake frequency.	2.4	5.6	12.2	-3.5	1.4	1.5
Comparative height size at age 10	0.4	1.9	5.6	0.1	-2.4	-0.5
Number of full sisters	1.5	1.9	2.4	-1.6	-1.3	1.3
Suffer from ‘nerves’	1.5	2.4	4.8	2.2	1.3	-0.8
Overall health rating	1.1	2.4	7.2	-2.7	0.0	-0.1
Chest pain or discomfort	0.4	0.5	1.2	0.6	1.1	0.4
Had major operations	0.6	0.7	1.3	-1.2	0.7	-0.6
Age at last live birth	1.0	1.4	4.1	0.4	-2.0	0.3
Family relationship satisfaction	4.1	5.1	13.0	1.5	0.3	-3.6
Leg pain on walking	0.4	0.5	0.9	-1.0	-0.8	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	0.1	0.7	-0.4
Commuting to job workplace: Car/motor vehicle	1.5	1.7	1.8	-1.3	-1.3	1.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.6	1.9	-0.2	0.0
Medication: Aspirin	0.5	0.7	1.4	-1.2	-0.4	0.7
Supplements: Vitamin C	1.6	1.9	5.2	2.3	-0.6	0.2
Knee pain experienced in last month	1.0	1.6	2.9	-1.7	1.4	0.2
Hypertension (Self-reported)	0.5	1.3	3.5	-1.9	-0.6	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	3.2	0.1	-1.5	1.8
Illnesses of father: Heart disease	2.2	3.1	6.8	-2.6	-1.3	-0.9
Illnesses of siblings: Diabetes	1.1	1.3	2.3	-1.5	0.1	-1.3
Smoking status: Previous	0.5	0.7	1.4	-0.8	-0.4	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	0.8	0.9	-0.7	-0.5
Whole body fat-free mass	0.8	4.5	7.6	-2.8	-0.3	-2.4
Leg fat-free mass (right)	0.9	4.7	7.7	-2.8	-0.7	-2.4
Arm fat percentage (left)	3.4	13.6	39.8	-6.3	-0.6	0.7
Average weekly red wine intake	1.6	2.4	6.6	-0.7	-2.6	-0.1
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.1	-0.6	1.4	-0.9
Mood swings	0.2	0.3	0.6	0.4	0.2	-0.8
Loneliness, isolation	1.3	1.8	4.5	0.4	0.9	-2.1
Long-standing illness, disability or infirmity	0.1	0.1	0.3	-0.1	0.2	0.5
Ever had bowel cancer screening	0.8	0.9	2.6	-0.0	1.6	0.3
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.2	-0.2	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	-0.1	0.2	0.1
Friendships satisfaction	4.7	5.8	13.2	0.8	1.9	-3.6
Qualifications: nursing, teaching	2.4	3.7	5.3	-0.6	-2.3	2.3
Commuting to job workplace: Walk	0.4	0.4	1.2	0.2	-0.3	-1.1
Eye problems/disorders: Cataract	0.8	0.9	2.2	-0.6	1.5	0.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.9	-0.4	-1.4	-0.7
Medication for cholesterol	1.0	1.5	2.3	1.4	1.5	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.3	-1.1	0.3	-0.6
Back pain experienced in last month	0.5	0.7	1.8	-1.3	0.5	-0.3
Mineral and other dietary supplements	2.6	3.4	7.9	-2.8	-1.4	0.6
Breast cancer (self-reported)	0.8	0.9	2.3	-1.5	-0.4	0.5
Asthma (self-reported)	0.4	0.8	1.7	-0.2	-0.9	1.3
Osteoporosis (self-reported)	0.6	0.8	1.0	-1.0	0.7	1.0
Osteoarthritis (self-reported)	1.5	2.0	5.1	-0.7	2.3	-0.6
Medication: Aspirin	0.6	0.8	2.2	-1.5	-0.0	0.3
Medication: Gliclazide	1.2	1.4	3.0	-1.7	-0.9	0.5
Illnesses of father: None of the above (group 1)	1.2	1.4	3.0	1.7	-0.3	1.1
Smoking status: Current	0.1	0.2	0.5	-0.7	0.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.0	1.0	-0.1	-0.6
Whole body water mass	0.8	4.4	7.2	-2.7	-0.3	-2.5
Leg predicted mass (right)	0.9	4.8	8.2	-2.9	-0.7	-2.4
Arm fat mass (left)	3.1	12.8	38.1	-6.2	-0.4	-0.2
Number of self-reported non-cancer illnesses	0.6	1.1	2.0	-1.4	-0.9	0.7
Average weekly champagne plus white wine intake	0.7	1.0	2.0	-1.4	-0.8	0.5
Miserableness	0.3	0.6	0.8	0.9	0.5	-0.9
Guilty feelings	0.2	0.3	0.7	-0.0	0.8	-0.6
Wears glasses or contact lenses	3.0	3.5	3.8	-1.9	-1.8	1.9
Ever taken oral contraceptive pill	1.3	1.5	2.8	-0.2	-1.7	-1.2
Hearing aid user	2.0	2.3	6.0	-1.0	-2.4	0.2
Mother’s age at death	0.8	1.0	1.9	0.5	-1.4	0.9
Financial situation satisfaction	0.7	0.9	1.6	-1.3	0.5	-1.0
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	-0.6	0.3	0.8
Commuting to job workplace: Public transport	1.9	2.3	5.2	2.3	1.0	-0.9
Eye problems/disorders: Glaucoma	0.8	1.0	2.7	1.6	0.3	-0.4
Medication: Blood pressure	1.2	2.3	6.2	-2.5	-0.9	-0.0
Pain type(s) experienced in last month: Hip pain	2.4	3.1	4.2	-2.0	1.1	-1.9
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.3	0.7	1.2	0.2
High cholesterol (Self-reported)	0.5	0.9	1.9	-1.4	-1.0	-0.1
Medication: Bendroflumethiazide	1.1	1.7	2.2	-0.9	-1.4	1.5
Medication: Paracetamol	0.3	0.4	1.0	-0.2	1.0	0.5
Medication: Lisinopril	0.3	0.4	0.8	-0.6	-0.9	0.2
Medication: Atorvastatin	0.2	0.2	0.4	-0.0	-0.5	-0.6
Illnesses of father: High blood pressure	2.0	2.4	3.7	-1.9	-0.0	-1.9
Alcohol drinker status: Never	4.1	4.9	10.8	-3.3	0.1	2.0
Ever smoked	0.3	0.6	1.6	0.2	-0.4	-1.3
Basal metabolic rate	1.0	5.3	10.6	-3.3	-0.4	-2.3
Leg fat percentage (left)	2.6	9.4	27.6	-5.2	0.6	0.5
Arm fat-free mass (left)	1.1	5.6	10.1	-3.2	0.3	-2.6
Number of operations (self-reported)	0.8	1.2	1.8	-1.4	0.3	1.3
Average weekly beer plus cider intake	0.0	0.1	0.1	0.1	-0.3	0.2
Irritability	0.5	0.9	2.2	0.4	-0.5	-1.5
Risk taking	1.0	1.4	2.2	-0.9	-1.1	1.5
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.4	0.4	0.5	-0.7
Fractured/broken bones in last 5 years	0.7	1.0	1.7	-0.9	-0.6	1.3
Age started oral contraceptive pill	1.2	1.5	3.5	-0.9	-0.2	1.9
Diastolic blood pressure, automated reading	0.6	1.8	4.1	-2.0	0.9	-0.8
Ever depressed for a whole week	0.6	0.7	1.7	-0.6	0.1	-1.3
Unable to work because of sickness or disability	4.0	5.1	12.0	-1.8	3.5	-0.5
Commuting to job workplace: Cycle	0.3	0.3	0.7	0.6	-0.3	-0.8
Myopia	0.4	0.6	1.6	1.3	-0.0	-0.5
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.7	1.9	0.9	-0.6
Cholesterol lowering medication	1.3	1.8	2.9	-1.3	-1.7	0.9
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.0	-1.4	-0.2	1.4
Pain experienced in last month	0.6	1.1	3.1	1.8	-0.2	0.0
Supplements: Calcium	1.0	1.1	3.3	1.8	0.1	-0.1
Basal cell carcinoma (self-reported)	0.6	0.8	1.9	-0.6	-0.1	-1.4
Heart attack/myocardial infarction (self-reported)	1.6	2.0	5.5	-2.3	-0.7	0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	0.6	-0.5	-0.2
Heart disease (siblings)	0.4	0.5	1.0	-0.8	-0.2	-1.0
Alcohol drinker status: Previous	3.0	3.4	9.6	-0.3	3.1	-0.8
Pack years of smoking	0.3	0.4	1.1	-1.1	0.2	-0.1
Impedance of whole body	1.2	6.0	13.6	3.7	0.5	2.0
Leg fat mass (left)	2.8	11.0	32.7	-5.7	-0.1	-0.5
Arm predicted mass (left)	1.0	5.2	9.9	-3.1	0.2	-2.4