Hub : Genes

GOLIM4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0540	0.0210	2.1e-03	0.000	0.007	0.000	0.009	0.000	3.4e-01	0.04700	3.4e-01	2.7e-02	3.2e-01
2	GTEx	Brain Frontal Cortex BA9	0.4584	0.1217	2.2e-03	0.005	NA	-0.009	NA	0.005	2.3e-01	NA	6.7e-01	NA	2.4e-01
3	GTEx	Nerve Tibial	0.0924	0.0406	6.5e-03	0.000	NA	0.000	NA	0.012	3.4e-01	NA	2.9e-01	NA	4.6e-02
4	YFS	Blood	0.0598	0.0192	7.6e-05	0.027	0.015	0.029	0.029	0.025	2.7e-09	0.00001	5.0e-10	6.4e-10	8.3e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.4	0.8	-0.2	0.9	0.9	0.3
Bipolar Disorder or Schizophrenia	0.2	0.4	1.4	0.2	1.2	0.2	0.4
Depressed Affect (Nagel 2018)	0.7	1.5	3.7	1.1	1.9	0.9	-0.5
Depression (Nagel 2018)	0.2	0.3	1.1	0.1	1.0	0.0	0.5
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.5	-0.8	0.2	-1.1	-1.2
Neuroticism (Nagel 2018)	0.2	0.5	1.6	0.6	1.3	0.4	-0.1
Schizophrenia (2018)	0.1	0.3	0.6	0.4	0.8	-0.4	0.3
Schizophrenia vs Biploar Disorder	0.7	0.9	2.1	1.5	1.0	0.6	0.1
Worry (Nagel 2018)	0.1	0.2	0.8	-0.0	-0.1	-0.2	0.9
Alzheimer’s Disease (in mother)	1.1	1.3	3.2	0.0	1.1	0.8	1.8
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.0	-0.2	0.1	-0.6
Alzheimer’s Disease (including proxy)	0.6	0.9	1.6	0.8	0.1	1.3	1.2
Crohns Disease (2017)	0.5	1.1	3.3	1.8	-1.0	0.4	-0.2
Irritable Bowel Disease (IBD)	0.4	1.0	2.5	1.6	-0.4	0.0	-1.1
Ulcerative Colitis (UC)	0.3	0.6	1.8	0.8	0.2	-0.0	-1.3
Major Depression (MDD)	0.4	0.4	0.8	-0.5	0.9	0.7	0.5
Reaction Time	0.6	1.1	3.6	-1.9	0.4	-0.4	0.6
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.1	-1.5	0.5	-1.8	-0.5
Breast Cancer	0.2	0.6	1.0	0.5	-1.0	-0.0	-1.0
Ovarian Cancer	0.5	0.7	2.4	0.0	-0.5	1.5	0.4
Prostate Cancer	0.2	0.2	0.6	-0.5	-0.1	-0.3	0.8
Age at First Birth	0.7	1.0	1.3	1.1	1.1	0.5	-1.1
Bipolar Disorder (2011)	0.5	0.5	1.7	-0.6	-1.3	-0.2	-0.1
Body Mass Index (BMI) (2010)	2.1	2.9	4.5	-2.1	-1.5	-1.5	1.6
Coronary Artery Disease (CAD)	0.5	0.5	1.8	-0.2	0.6	-0.2	-1.3
Crohns Disease (2012)	0.5	0.8	1.6	1.2	-0.9	0.6	0.6
Mean Putamen Volume	1.0	1.1	2.9	-0.6	0.4	-1.7	1.1
Fasting Glucose	1.9	2.3	4.9	1.1	-2.2	1.1	1.4
HbA1C	1.0	1.1	3.5	0.9	-1.9	0.1	-0.3
HDL Cholesterol	0.4	0.7	1.5	-1.2	0.3	0.2	1.1
LDL Cholesterol	0.3	0.5	0.7	0.7	0.8	-0.8	-0.2
Lupus	0.1	0.1	0.2	-0.5	0.0	0.5	-0.3
Neuroticism (2016)	0.3	0.4	1.0	-0.9	0.1	-1.0	-0.0
Primary Biliary Cirrhosis	1.4	2.0	4.5	-1.5	-0.5	-1.0	2.1
Rheumatoid Arthritis	0.3	0.4	1.5	-0.0	-1.2	-0.3	-0.4
Schizophrenia (2014)	0.6	1.4	3.7	1.1	1.9	0.5	0.5
Triglycerides	0.4	0.7	1.7	0.4	-0.4	-1.3	1.0
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.7	0.7	-1.7	1.2	-0.2
Ulcerative Colitis	0.6	0.9	2.0	1.3	-0.1	-0.1	-1.4
Blood Eosinophil Count	0.5	3.7	8.3	2.9	-1.8	0.6	-1.6
Blood Platelet Count	0.8	9.8	15.4	3.9	-3.8	-0.2	-3.1
Blood Red Count	0.1	1.1	2.0	0.1	0.5	-1.4	-1.4
Blood White Count	0.1	0.7	1.6	0.6	-0.8	0.0	-1.3
Heel T-Score	0.8	6.6	15.0	-3.9	-0.5	-2.0	2.7
BMI	0.3	1.9	3.8	1.6	-1.9	0.6	-0.8
Height	0.9	18.1	37.3	6.1	-0.4	0.6	-5.9
Waist Hip Ratio (WHR)	0.0	0.1	0.2	0.2	0.3	-0.2	-0.4
Systolic Blood Pressure	0.5	2.3	8.5	0.5	-0.0	0.8	2.9
Smoking Status	0.4	0.9	2.7	-0.5	-0.8	-0.2	1.6
Allergy or Eczema	0.6	1.5	3.0	-0.8	0.8	-1.7	-1.3
Cardiovascular Disease	0.5	1.6	3.3	0.5	-0.9	1.4	1.8
Hypothyroidism (self reported)	0.5	1.2	2.9	-1.7	-0.8	0.3	1.1
Respiratory disease	0.5	1.0	3.3	-0.9	-1.8	-0.1	-0.0
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.1	0.1	-1.6	1.1	1.8
Lung FEV1/FVC ratio	0.2	1.1	2.3	1.5	-0.1	1.5	0.1
Lung FVC	0.5	2.3	6.5	-1.0	-0.0	-2.6	-1.4
Neuroticism	0.2	0.6	1.7	-0.0	1.3	0.2	0.7
Chronotype (morning person)	0.4	0.9	2.6	0.5	0.4	0.6	-1.6
Hair Pigment	0.0	0.7	1.6	1.3	-0.9	0.6	-0.3
Tanning	0.2	2.1	3.2	0.7	1.5	1.8	1.6
Hand grip strength (left)	0.3	0.7	2.4	0.7	1.5	-0.3	0.3
Number of treatments/medications taken	0.1	0.2	0.4	0.7	-0.2	0.3	0.3
Average weekly spirits intake	0.3	0.3	0.9	-0.5	-0.1	1.0	-0.5
Sensitivity / hurt feelings	0.2	0.4	0.7	-0.8	0.6	0.6	0.0
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.8	0.8	1.3	0.3	0.2
Hearing difficulty/problems: Yes	0.1	0.2	0.3	-0.2	-0.6	-0.4	-0.4
Relative age of first facial hair	0.3	0.5	0.9	-0.8	-0.7	-1.0	0.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.4	-0.5	-1.2	0.6	0.8
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.9	-0.4	-1.4	-1.3	-0.4
Ever had hysterectomy (womb removed)	0.6	0.7	1.9	-1.4	-0.9	-0.3	0.1
Systolic blood pressure, automated reading	0.4	1.2	3.9	-0.8	-0.4	-0.2	2.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.0	0.2	-0.9	0.8	1.4
Angina	1.6	2.1	3.9	-1.9	0.4	-0.8	2.0
Medication for hormone replacement therapy	3.1	3.5	7.3	2.2	0.6	1.2	-2.7
Vitamin and mineral supplements	0.5	0.7	2.3	0.7	-0.4	-0.1	-1.5
Supplements: Zinc	0.5	0.5	1.2	-1.1	0.4	-0.8	0.3
Medication: Co-codamol	0.2	0.3	0.5	-0.5	0.5	-0.4	0.7
Medication: Metformin	0.7	1.0	2.3	-1.5	-0.6	-1.1	0.3
Diabetes (father)	0.3	0.3	0.8	0.0	0.9	0.8	0.2
Diabetes (mother)	3.7	4.7	12.9	-3.6	-1.4	-0.9	1.9
Severe depression (siblings)	0.2	0.2	0.6	0.3	0.3	0.3	0.8
Pack years adult smoking proportion	0.6	1.0	2.2	1.2	-0.2	1.5	-0.4
Impedance of leg (right)	0.3	1.4	3.5	-0.6	1.9	0.6	1.2
Leg fat-free mass (left)	1.1	5.8	9.3	3.0	-2.2	0.1	-3.1
Trunk fat percentage	0.3	1.1	1.5	1.2	-1.2	1.2	-0.5
Hand grip strength (right)	0.3	0.8	2.2	1.5	0.7	0.6	-0.3
Townsend deprivation index at recruitment	0.4	0.5	1.9	0.4	-1.4	-0.1	0.4
Current tobacco smoking	0.5	0.8	1.7	0.6	0.7	0.9	1.3
Average weekly fortified wine intake	1.5	1.8	3.8	-0.6	1.5	-0.9	-1.9
Maternal smoking around birth	0.9	1.3	2.3	-1.5	-0.8	-1.5	0.3
Fed-up feelings	0.4	0.7	2.5	-0.4	1.6	-0.5	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	4.5	0.2	2.1	0.3	0.0
Relative age voice broke	0.4	0.6	1.7	-1.3	-0.6	-0.2	0.5
Taking other prescription medications	0.2	0.4	0.5	-0.7	-0.6	-0.3	0.7
Age when periods started (menarche)	0.3	0.8	2.0	-1.0	-0.4	-0.4	1.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.7	-0.1	-0.2	1.3	0.5
Heel bone mineral density (BMD) T-score, automated (left)	2.2	4.9	9.7	-2.9	-0.4	-3.1	1.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.4	-0.1	-0.4	0.3
Qualifications: CSEs or equivalent	0.7	1.0	2.2	-0.3	-1.5	-0.4	1.2
Serious illness, injury or assault to yourself	0.9	1.1	1.8	-0.1	0.9	1.3	1.3
High blood pressure	0.1	0.4	1.0	0.0	-0.7	-0.4	1.0
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.2	-0.1	0.1	-1.1	-0.9
Multivitamins +/- minerals	0.2	0.2	0.9	-0.1	0.0	-0.2	1.0
Stomach or abdominal pain in last month	1.7	2.1	4.7	-1.8	-0.5	-0.7	2.2
Supplements: Glucosamine	0.3	0.4	1.0	-0.6	-0.5	0.4	1.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.5	0.8	-1.2	-0.6	-0.0
Medication: Atenolol	1.7	2.1	5.1	-2.2	0.1	-1.7	0.8
Medication: Levothyroxine sodium	0.6	1.0	1.2	-1.1	-0.8	1.1	0.9
Sitting height	0.6	4.5	9.7	2.4	-1.1	-1.2	-3.1
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	0.8	-0.5	1.0	0.2
High blood pressure (mother)	0.5	0.8	2.7	0.5	-1.6	-0.1	-0.2
Body mass index (BMI)	0.3	1.4	5.5	0.4	-2.4	-0.1	-0.0
Impedance of leg (left)	0.3	1.7	2.4	-0.3	1.6	1.3	1.6
Leg predicted mass (left)	1.1	5.8	9.2	3.0	-2.2	0.1	-3.0
Trunk fat mass	0.5	2.2	3.7	1.9	-1.7	1.0	-1.2
Waist circumference	0.5	1.9	3.8	1.2	-2.0	-0.1	-1.5
Number of incorrect matches in round	1.0	1.6	2.3	-1.5	1.2	-0.4	1.5
Past tobacco smoking	1.2	2.2	5.0	1.5	1.2	0.5	-2.2
Alcohol usually taken with meals	0.4	0.7	1.9	0.4	-0.2	-0.8	-1.4
Nervous feelings	0.2	0.3	1.1	-0.0	1.0	-0.4	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.4	0.5	0.4	-0.6	-0.5
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.5	-0.7	-0.1	-0.3
Hair/balding pattern: Pattern 2	0.3	0.3	0.7	-0.4	-0.0	0.8	0.7
Had menopause	2.1	2.7	5.5	-0.4	-1.6	-1.6	-2.3
Had other major operations	0.4	0.5	1.8	-0.2	0.4	0.2	-1.3
Forced vital capacity (FVC)	0.5	2.0	5.7	1.3	-0.5	-0.8	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.5	11.7	-3.1	-0.1	-3.4	0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.0	0.6	1.0	0.4	0.7
Qualifications: None of the above	0.1	0.1	0.3	-0.4	0.1	0.5	0.4
Financial difficulties in last 2 years	0.9	1.2	2.3	-1.4	-0.8	-0.2	1.5
Mouth/teeth dental problems	0.5	0.7	1.4	0.9	-0.5	1.2	0.6
Heart attack	0.9	1.2	2.9	-1.7	0.7	-0.4	1.1
Allergy	0.5	1.1	2.2	0.5	-0.1	1.5	1.3
Pain all over the body in last month	1.3	1.3	3.1	-1.2	-0.9	0.2	1.8
Diabetes (self-reported)	1.5	2.3	4.6	-1.1	-2.1	-0.7	1.7
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	2.4	-1.6	-0.3	-1.4	-0.2
Medication: Ramipril	0.6	0.8	1.7	0.1	1.1	-1.3	-0.5
Medication: Simvastatin	1.3	2.0	5.0	0.5	-1.4	0.8	2.2
Fluid intelligence score	0.6	1.3	4.1	-0.1	-0.5	-2.0	-1.0
Illnesses of siblings	0.8	1.1	2.1	-0.9	-0.3	-1.5	-1.1
Neuroticism score	0.2	0.4	1.1	-0.3	1.1	-0.2	0.4
Weight	0.8	3.8	5.5	2.4	-2.3	0.3	-2.0
Impedance of arm (right)	0.1	0.7	1.3	0.3	0.9	1.1	-0.7
Arm fat percentage (right)	0.3	1.2	4.3	0.5	-2.1	0.4	-0.0
Trunk fat-free mass	0.9	5.2	8.1	2.9	-2.3	-0.5	-2.7
Hip circumference	0.6	2.5	4.2	2.0	-1.4	-0.1	-2.0
Time employed in main current job	0.3	0.4	0.8	0.9	-0.6	-0.1	-0.7
Alcohol intake versus 10 years previously	0.6	0.9	2.6	-0.3	-0.6	0.7	1.6
Father’s age at death	0.3	0.4	1.0	0.2	-0.4	1.0	0.6
Worrier / anxious feelings	0.2	0.4	0.8	-0.0	0.7	-0.5	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.1	0.4	0.3	0.3	1.0
Falls in the last year	0.6	0.8	1.2	0.4	1.1	0.9	1.1
Hair/balding pattern: Pattern 3	0.2	0.2	0.4	-0.2	0.6	0.6	0.2
Number of live births	0.4	0.6	1.8	1.4	0.1	-0.5	-0.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	5.6	2.2	-0.3	-0.7	-2.4
Pulse rate	0.4	0.7	2.2	0.3	1.5	0.3	-0.7
Happiness	3.2	3.9	9.1	-1.7	1.7	0.9	3.0
Noisy workplace	0.1	0.1	0.1	-0.4	-0.1	-0.1	0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.0	0.8	1.0	0.4	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.7	0.8	0.4	0.2	-0.5
Mouth/teeth dental problems: Dentures	0.4	0.7	2.3	-0.7	1.5	0.4	0.1
Asthma	1.2	2.4	5.9	-1.6	-2.4	-1.0	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	0.9	-0.6	1.0	0.2	0.9
Medication: Cholesterol lowering	1.1	1.7	4.9	-1.0	0.9	0.2	2.2
Depression (self-reported)	0.3	0.3	0.8	-0.5	0.0	-0.9	0.6
Medication: Lansoprazole	0.7	0.8	2.5	0.4	-0.6	-0.6	-1.6
Prospective memory result	0.8	1.0	1.8	1.1	0.9	1.3	0.5
Lung cancer (father)	0.6	0.7	1.4	1.2	0.1	0.5	-1.1
Illnesses of mother	0.1	0.2	0.5	-0.1	-0.1	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	4.2	1.1	-0.3	-1.0	-2.0
Pulse wave Arterial Stiffness index	1.2	1.4	3.4	-0.2	1.8	1.4	-0.5
Impedance of arm (left)	0.1	0.7	1.7	0.1	1.3	1.0	-0.3
Arm fat mass (right)	0.5	2.1	5.9	1.4	-2.4	0.1	-0.9
Trunk predicted mass	0.9	5.3	8.3	2.9	-2.3	-0.4	-2.7
Standing height	0.9	9.4	18.7	4.3	-0.1	0.8	-4.3
Length of working week for main job	1.2	1.3	3.0	0.8	-1.7	1.2	0.0
Exposure to tobacco smoke at home	4.6	5.1	10.1	2.8	-0.5	1.4	-3.2
Breastfed as a baby	0.7	0.9	2.4	-0.6	0.7	-1.6	0.7
Tense / ‘highly strung’	0.8	1.4	2.4	-1.4	0.9	-0.7	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.0	-0.9	-0.4	-0.3	1.0
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	-0.1	-0.3	-0.3	0.8
Birth weight of first child	0.5	1.0	1.9	1.3	1.4	0.5	-0.2
Peak expiratory flow (PEF)	0.6	1.4	3.2	0.7	-0.5	-1.3	-1.8
Pulse wave reflection index	0.7	0.9	1.2	-0.5	-1.0	-1.1	-1.0
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.8	0.9	-0.2	-0.1	0.8
Loud music exposure frequency	1.5	1.6	2.2	-1.0	1.0	1.5	1.5
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	0.2	0.1	0.1	-0.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.8	-0.5	-1.4	-0.2	1.0
Blood clot in the leg (DVT)	0.6	0.8	1.2	1.1	1.1	0.3	-0.8
Medication: Paracetamol	0.3	0.5	1.0	0.8	1.0	0.2	0.7
Headache pain in last month	0.3	0.5	0.8	-0.8	0.8	-0.9	-0.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.5	0.7	-0.4	0.7	-1.9
Glaucoma (self-reported)	0.5	0.5	1.9	-0.4	-0.1	-1.4	0.2
Gout (self-reported)	1.9	2.6	4.7	-2.1	-2.2	-0.3	1.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.5	-1.6	0.0	0.9	1.1
Medication: Amlodipine	0.8	1.1	2.4	0.7	-0.3	-1.2	-1.5
Medication: Ventolin 100micrograms inhaler	3.5	4.5	13.6	-1.4	-3.7	-0.9	-1.3
Birth weight	0.6	1.3	3.1	0.6	-1.1	-1.8	-0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.0	0.4	0.4	-0.3
High blood pressure (siblings)	0.4	0.6	1.1	0.8	-0.4	1.1	0.6
Forced vital capacity (FVC), Best measure	0.4	1.4	3.7	0.3	-0.4	-1.3	-1.9
Body fat percentage	0.2	0.7	1.7	0.7	-1.3	0.8	-0.1
Leg fat percentage (right)	0.2	0.8	2.4	-0.5	-1.6	-0.1	0.6
Arm fat-free mass (right)	0.8	3.9	7.5	2.7	-1.9	-0.2	-2.2
Exposure to tobacco smoke outside home	1.1	1.5	6.0	0.0	-2.4	0.1	0.1
Comparative body size at age 10	0.3	0.7	1.4	0.9	-1.2	0.8	-0.2
Number of full brothers	0.7	0.9	2.3	0.8	-1.5	0.5	0.7
Worry too long after embarrassment	0.1	0.1	0.3	0.6	0.4	0.3	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.2	0.3	-0.6	0.6
Wheeze or whistling in the chest in last year	0.3	0.5	0.7	-0.7	-0.8	0.8	-0.3
Number of children fathered	0.3	0.3	0.9	-0.3	-1.0	0.3	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.9	-0.3	-0.9	-0.3	-1.4
Age at first live birth	0.2	0.4	1.1	1.1	0.7	0.0	-0.2
Pulse wave peak to peak time	1.0	1.2	3.1	0.6	-1.8	-1.2	0.2
Health satisfaction	2.2	2.8	7.5	-0.3	1.3	1.4	2.7
Shortness of breath walking on level ground	0.5	0.6	1.5	0.7	0.2	1.2	0.5
Qualifications: College or University degree	0.3	0.8	3.1	-0.4	-0.3	-1.8	-0.3
Eye problems/disorders: None of the above	1.0	1.2	1.5	-0.7	1.2	1.2	1.2
Mouth/teeth dental problems: Loose teeth	2.6	3.0	7.6	2.7	-0.0	1.7	-1.2
Emphysema/chronic bronchitis	1.4	1.6	2.7	-1.1	-1.5	-1.6	0.1
Medication for pain relief, constipation, heartburn	0.4	0.7	1.6	0.3	-1.1	-0.3	-1.3
Neck or shoulder pain in last month	2.7	3.8	6.6	-2.5	-0.5	-2.6	1.5
Medication: Blood pressure	0.8	1.3	4.3	-0.8	0.5	-0.4	2.1
Angina (self-reported)	1.7	2.2	3.8	-1.9	0.4	-1.1	1.9
Migraine (self-reported)	0.6	0.7	1.3	0.8	1.0	1.1	0.0
Medication: Ibuprofen	0.4	0.5	1.1	-0.3	1.1	0.8	0.3
Medication: Allopurinol	0.6	0.8	1.7	-0.6	-1.3	0.4	1.0
Medication: Omeprazole	0.3	0.3	1.2	0.2	0.1	0.0	1.1
Medication: Seretide 50 evohaler	1.2	1.4	2.9	-1.7	-1.3	-1.0	0.3
Mean time to correctly identify matches	0.7	1.3	3.8	-1.9	1.0	-0.4	0.5
Heart disease (mother)	0.7	0.8	1.6	1.3	0.9	0.5	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	5.2	-1.1	2.3	0.2	0.6
Whole body fat mass	0.4	1.6	3.1	1.5	-1.8	0.5	-0.8
Leg fat mass (right)	0.3	1.2	3.3	1.0	-1.8	0.2	-0.5
Arm predicted mass (right)	0.8	4.3	7.0	2.6	-1.9	-0.4	-2.5
Pulse rate, automated reading	0.3	0.9	1.6	0.8	1.1	-0.4	-1.3
Alcohol intake frequency.	0.9	2.1	3.2	1.8	1.6	1.5	-0.4
Comparative height size at age 10	1.3	7.0	12.6	3.5	1.4	1.1	-3.5
Number of full sisters	0.3	0.4	0.9	-0.5	-0.9	-0.2	0.7
Suffer from ‘nerves’	0.6	0.9	2.5	-1.6	0.2	-0.8	0.6
Overall health rating	1.1	2.4	5.4	-1.2	-1.7	-0.2	2.3
Chest pain or discomfort	0.1	0.1	0.2	0.1	-0.5	-0.2	-0.5
Had major operations	2.3	2.7	5.1	2.3	-0.2	1.7	-1.6
Age at last live birth	0.2	0.4	1.2	1.1	0.4	-0.3	-0.2
Family relationship satisfaction	1.3	1.6	3.0	0.5	0.7	1.7	1.6
Leg pain on walking	0.6	0.8	1.4	-1.2	0.5	-1.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	3.0	0.1	-0.6	1.7	0.2
Commuting to job workplace: Car/motor vehicle	1.5	1.7	4.0	2.0	1.0	0.7	-1.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	3.0	0.0	-0.1	0.1	-1.7
Medication: Aspirin	1.0	1.3	3.1	-0.4	1.0	1.1	1.8
Supplements: Vitamin C	0.1	0.1	0.2	0.4	-0.2	-0.2	0.2
Knee pain experienced in last month	1.3	1.9	3.1	-1.8	1.2	-1.5	-1.0
Hypertension (Self-reported)	0.1	0.4	0.7	-0.4	-0.7	-0.4	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	2.5	1.6	1.3	1.5	0.5
Illnesses of father: Heart disease	0.4	0.6	1.4	0.5	0.4	0.8	1.2
Illnesses of siblings: Diabetes	1.0	1.2	2.3	0.1	1.2	1.0	1.5
Smoking status: Previous	1.2	1.7	3.6	-1.2	-1.9	-0.7	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.6	0.8	0.0	1.3	0.2
Whole body fat-free mass	1.0	6.0	9.7	3.1	-2.3	-0.1	-3.0
Leg fat-free mass (right)	1.2	6.2	10.1	3.0	-2.4	0.4	-3.2
Arm fat percentage (left)	0.3	1.1	4.3	0.3	-2.1	0.2	0.1
Average weekly red wine intake	1.2	1.8	3.4	-1.0	-1.4	-1.9	-0.9
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	0.0	0.7	-0.4	-0.6
Mood swings	0.9	1.6	2.7	1.6	1.4	1.1	-0.7
Loneliness, isolation	0.5	0.6	1.3	-0.6	1.1	0.4	0.8
Long-standing illness, disability or infirmity	0.4	0.6	1.2	0.1	-1.0	0.4	1.1
Ever had bowel cancer screening	0.7	0.9	1.7	-1.2	0.0	-0.4	1.3
Diabetes diagnosed by doctor	0.9	1.5	2.9	-0.9	-1.4	-0.6	1.7
Ever had stillbirth, spontaneous miscarriage or termination	3.0	3.2	8.3	-2.9	-0.1	-1.3	1.7
Friendships satisfaction	0.5	0.6	1.5	-0.1	0.4	0.8	1.2
Qualifications: nursing, teaching	0.5	0.8	2.0	-0.7	1.4	-0.7	-0.5
Commuting to job workplace: Walk	0.3	0.3	1.2	-0.3	-0.1	-0.3	-1.1
Eye problems/disorders: Cataract	1.7	2.0	5.9	2.4	-0.6	0.7	-1.1
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	6.6	-1.7	1.1	-2.6	-0.3
Medication for cholesterol	1.7	2.6	4.0	-2.0	1.7	-0.8	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.3	0.3	1.0	-0.8	1.2
Back pain experienced in last month	1.8	2.7	6.9	-1.7	0.3	-2.6	1.0
Mineral and other dietary supplements	0.4	0.5	1.2	1.1	-0.1	-0.1	-0.9
Breast cancer (self-reported)	0.4	0.5	1.9	-0.0	1.4	-0.2	-0.4
Asthma (self-reported)	1.4	2.8	6.1	-1.8	-2.5	-1.4	-0.3
Osteoporosis (self-reported)	0.9	1.1	3.5	-0.3	-1.9	0.7	0.6
Osteoarthritis (self-reported)	1.8	2.3	4.8	-2.2	1.5	-1.3	0.7
Medication: Aspirin	0.8	1.0	2.1	-0.6	1.1	0.8	1.4
Medication: Gliclazide	0.9	1.0	1.6	1.3	-0.4	0.9	-1.2
Illnesses of father: None of the above (group 1)	1.3	1.6	3.5	-1.5	-0.1	-1.9	-0.9
Smoking status: Current	0.7	1.1	3.1	0.3	0.5	0.9	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.0	-0.2	0.8	-1.1	-1.4
Whole body water mass	1.0	5.8	9.1	3.0	-2.4	-0.2	-2.9
Leg predicted mass (right)	1.2	6.3	10.3	3.0	-2.4	0.3	-3.2
Arm fat mass (left)	0.5	2.2	6.0	1.4	-2.4	0.1	-1.0
Number of self-reported non-cancer illnesses	1.2	2.1	3.5	-1.9	-1.1	-1.4	1.2
Average weekly champagne plus white wine intake	0.3	0.4	0.7	-0.3	0.1	-0.8	-0.8
Miserableness	0.5	0.8	2.0	0.9	1.4	0.4	-0.5
Guilty feelings	0.2	0.2	0.7	0.0	-0.2	0.5	-0.8
Wears glasses or contact lenses	0.7	0.8	1.4	-1.2	0.9	-0.7	-0.8
Ever taken oral contraceptive pill	2.5	2.7	7.7	-1.6	-0.7	-0.5	2.8
Hearing aid user	0.8	0.9	1.2	1.1	1.1	0.8	-0.8
Mother’s age at death	3.7	4.6	7.2	2.7	-0.3	2.0	-2.6
Financial situation satisfaction	1.1	1.4	4.7	0.1	-0.7	0.5	2.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.3	-0.9	0.5	0.7	1.1
Commuting to job workplace: Public transport	0.9	1.1	2.6	-1.6	1.0	-0.7	0.6
Eye problems/disorders: Glaucoma	1.3	1.6	5.9	-0.0	0.7	-2.4	-0.2
Medication: Blood pressure	0.5	1.0	2.2	-0.4	-1.5	-1.0	-0.8
Pain type(s) experienced in last month: Hip pain	0.8	0.9	1.8	-1.1	-0.8	-1.3	0.0
Supplements: Fish oil (including cod liver oil)	0.7	1.0	2.3	-1.5	0.5	-1.1	-0.2
High cholesterol (Self-reported)	0.4	0.7	1.3	-0.5	-0.5	0.9	1.2
Medication: Bendroflumethiazide	0.4	0.7	0.9	-0.9	0.9	0.8	0.6
Medication: Paracetamol	0.9	1.3	2.8	1.7	1.4	0.7	-0.4
Medication: Lisinopril	0.6	0.7	1.8	0.5	-1.4	0.5	0.8
Medication: Atorvastatin	0.5	0.6	1.0	-0.9	0.6	-1.0	0.4
Illnesses of father: High blood pressure	1.4	1.8	3.6	1.9	-1.6	0.5	0.9
Alcohol drinker status: Never	0.6	0.8	2.8	0.4	0.3	-0.3	-1.7
Ever smoked	1.2	2.1	6.1	-1.1	-1.0	-0.0	2.5
Basal metabolic rate	1.1	6.0	9.8	3.1	-2.4	0.1	-2.9
Leg fat percentage (left)	0.3	0.9	3.0	-0.3	-1.7	0.1	0.7
Arm fat-free mass (left)	1.0	5.2	8.9	3.0	-2.4	-0.1	-2.5
Number of operations (self-reported)	0.2	0.3	0.9	-1.0	0.4	-0.1	0.1
Average weekly beer plus cider intake	0.5	0.7	1.9	0.8	0.3	1.4	0.1
Irritability	0.8	1.4	5.1	-0.6	2.2	-0.3	-0.2
Risk taking	0.5	0.7	1.0	0.6	-0.8	1.0	0.9
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.4	-1.2	0.2	-0.8	-0.2
Fractured/broken bones in last 5 years	0.4	0.6	1.3	-0.3	-1.1	-0.3	0.9
Age started oral contraceptive pill	0.7	0.9	1.6	0.9	-0.1	-1.1	-1.2
Diastolic blood pressure, automated reading	0.4	1.3	4.1	-0.3	-2.0	-0.5	0.8
Ever depressed for a whole week	0.5	0.6	1.3	0.5	-1.0	-1.1	0.0
Unable to work because of sickness or disability	0.1	0.1	0.3	0.5	-0.1	0.3	0.2
Commuting to job workplace: Cycle	0.8	1.0	3.2	0.4	0.6	-0.4	1.8
Myopia	0.5	0.8	1.2	1.1	0.3	-1.0	-0.9
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.6	0.6	0.1	0.4	-1.3
Cholesterol lowering medication	0.6	0.9	2.9	0.5	-1.7	0.6	0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.7	0.3	0.6	0.5	1.3
Pain experienced in last month	3.5	5.9	11.7	3.4	-0.2	3.0	-1.6
Supplements: Calcium	0.8	0.9	3.0	-0.0	-1.7	0.6	0.5
Basal cell carcinoma (self-reported)	1.1	1.3	3.3	-0.7	1.0	-0.7	1.8
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.3	-1.8	0.9	-0.6	1.0
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	2.8	1.7	1.2	0.7	-1.2
Heart disease (siblings)	0.0	0.0	0.2	0.0	0.1	0.2	0.4
Alcohol drinker status: Previous	1.8	2.0	7.0	0.3	0.9	0.4	-2.6
Pack years of smoking	0.7	1.1	3.1	1.0	0.1	1.7	-0.3
Impedance of whole body	0.3	1.5	4.1	0.0	2.0	1.4	0.1
Leg fat mass (left)	0.3	1.4	3.9	1.1	-2.0	0.3	-0.4
Arm predicted mass (left)	0.9	4.7	7.0	2.6	-2.3	-0.2	-2.6