Hub : Genes

GPC5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.276	0.0370	0.0e+00	0.180	0.192	0.246	0.270	0.265	2.3e-21	7.3e-23	1.2e-29	6.6e-33	3.8e-32
2	ROSMAP	Brain Pre-frontal Cortex	0.260	0.0412	8.9e-12	0.081	0.114	0.115	0.113	0.103	1.4e-10	1.8e-14	1.4e-14	2.8e-14	4.0e-13
3	TCGA	Pancreatic Adenocarcinoma	0.165	0.0630	5.4e-03	-0.005	0.020	0.035	NA	0.011	5.6e-01	5.0e-02	1.4e-02	NA	1.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.5	0.7	0.5	0.6	0.8
Bipolar Disorder or Schizophrenia	0.3	0.8	1.3	-0.3	0.9	1.1
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.3	-0.0	-0.6
Depression (Nagel 2018)	0.5	0.8	1.8	-1.3	-0.2	0.8
Intelligence (Savage-Jansen 2018)	0.7	2.0	5.4	2.3	-0.1	0.8
Neuroticism (Nagel 2018)	0.1	0.3	0.8	-0.2	-0.1	0.9
Schizophrenia (2018)	0.3	0.5	0.7	-0.8	0.5	0.8
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.7	-0.3	-0.5
Worry (Nagel 2018)	0.3	0.6	1.7	-0.2	-0.1	1.3
Alzheimer’s Disease (in mother)	2.5	2.9	4.2	2.1	1.9	-0.9
Alzheimer’s Disease (in father)	3.8	4.1	5.9	-2.4	-0.9	-2.4
Alzheimer’s Disease (including proxy)	1.8	2.6	3.5	1.2	1.9	-1.7
Crohns Disease (2017)	0.4	0.8	1.8	-1.3	-0.3	0.7
Irritable Bowel Disease (IBD)	0.9	2.1	4.2	-2.1	-1.4	-0.2
Ulcerative Colitis (UC)	1.4	2.6	4.0	-2.0	-1.8	-0.8
Major Depression (MDD)	0.3	0.4	1.2	-1.1	0.1	0.2
Reaction Time	1.9	3.7	6.1	-2.5	-0.6	2.1
Verbal and Numeric Reasoning (VNR)	1.0	2.3	5.9	2.4	1.0	0.1
Breast Cancer	0.8	1.9	3.9	-2.0	-1.0	-0.9
Ovarian Cancer	0.7	0.9	1.4	1.2	1.1	-0.2
Prostate Cancer	0.6	0.9	1.2	1.0	1.1	-0.7
Age at First Birth	0.8	1.2	2.7	0.5	-0.8	1.6
Bipolar Disorder (2011)	1.1	1.0	1.6	0.2	1.3	1.2
Body Mass Index (BMI) (2010)	0.3	0.5	1.0	-0.6	-0.2	-1.0
Coronary Artery Disease (CAD)	0.9	1.1	1.9	-0.8	-0.9	1.4
Crohns Disease (2012)	0.3	0.5	0.9	-0.7	-0.3	0.9
Mean Putamen Volume	0.6	0.6	1.0	-0.9	-0.3	-1.0
Fasting Glucose	1.4	1.7	3.8	1.9	1.1	0.1
HbA1C	0.5	0.6	1.1	0.1	-1.0	-0.8
HDL Cholesterol	1.2	2.0	2.2	-1.3	-1.5	-1.4
LDL Cholesterol	0.2	0.4	0.6	0.7	0.3	0.8
Lupus	0.1	0.2	0.3	-0.1	-0.6	-0.5
Neuroticism (2016)	0.2	0.2	0.4	-0.5	0.6	0.3
Primary Biliary Cirrhosis	0.1	0.2	0.3	0.2	0.5	0.5
Rheumatoid Arthritis	0.2	0.3	0.4	-0.5	0.5	-0.6
Schizophrenia (2014)	0.5	1.1	2.3	-1.5	0.4	0.9
Triglycerides	0.2	0.4	0.9	0.9	0.2	0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.8	-0.9	-0.3	-0.6
Ulcerative Colitis	1.8	2.6	3.8	-1.5	-1.9	-1.4
Blood Eosinophil Count	0.0	0.4	0.6	0.8	0.4	-0.6
Blood Platelet Count	0.1	1.1	2.1	1.5	-0.9	0.5
Blood Red Count	0.2	1.6	4.0	-0.7	-2.0	-0.6
Blood White Count	0.4	2.9	4.6	-1.0	-1.7	-2.1
Heel T-Score	0.0	0.2	0.4	-0.3	-0.6	-0.3
BMI	0.6	3.5	5.8	-2.4	-1.0	-1.9
Height	3.3	64.4	114.5	10.7	8.8	0.7
Waist Hip Ratio (WHR)	0.2	0.7	1.7	0.3	-0.5	-1.3
Systolic Blood Pressure	0.1	0.3	0.6	0.6	-0.8	0.2
Smoking Status	0.7	1.7	2.9	1.4	0.5	-1.7
Allergy or Eczema	0.7	2.0	4.9	2.2	0.9	0.4
Cardiovascular Disease	1.0	3.4	4.7	-2.2	-2.0	-1.3
Hypothyroidism (self reported)	0.5	1.2	2.6	-0.6	0.9	1.6
Respiratory disease	0.9	2.1	3.3	1.8	1.5	-0.7
Type 2 Diabetes (T2D) (2018)	1.4	2.7	7.6	0.2	0.7	-2.8
Lung FEV1/FVC ratio	0.1	0.7	1.7	-0.3	-0.5	-1.3
Lung FVC	0.2	1.2	3.5	-0.1	-0.1	1.9
Neuroticism	0.5	1.1	1.9	-1.2	-1.4	0.3
Chronotype (morning person)	0.5	1.1	2.8	-0.6	-0.3	-1.7
Hair Pigment	0.0	1.0	1.9	-0.7	0.7	1.4
Tanning	0.2	2.7	7.2	-0.9	-0.3	-2.7
Hand grip strength (left)	1.1	3.0	6.8	2.6	1.4	0.5
Number of treatments/medications taken	0.5	0.8	1.6	-0.9	0.2	-1.3
Average weekly spirits intake	1.6	2.0	3.0	1.7	1.1	1.3
Sensitivity / hurt feelings	1.4	2.4	4.1	-2.0	-1.1	1.4
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.8	-1.7	-0.6	0.2
Hearing difficulty/problems: Yes	0.7	1.1	2.2	-1.5	-0.6	-0.9
Relative age of first facial hair	1.5	3.1	4.6	-2.0	-2.1	-0.8
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	2.9	-1.4	-1.0	-1.7
Ever used hormone-replacement therapy (HRT)	1.3	1.6	3.1	-0.4	1.2	-1.8
Ever had hysterectomy (womb removed)	1.2	1.3	3.5	-1.9	-0.3	-0.6
Systolic blood pressure, automated reading	0.2	0.5	1.1	1.1	0.4	0.4
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	2.1	-1.3	-1.4	-1.4
Angina	1.3	1.7	4.2	-2.0	-0.5	-0.8
Medication for hormone replacement therapy	0.7	0.7	1.2	-0.7	0.7	-1.1
Vitamin and mineral supplements	0.7	1.0	2.8	-0.4	0.2	1.7
Supplements: Zinc	0.5	0.5	1.1	0.5	-0.5	1.1
Medication: Co-codamol	2.1	2.5	3.4	-1.8	-1.6	-1.1
Medication: Metformin	1.5	2.1	6.1	-0.1	0.4	-2.5
Diabetes (father)	2.5	3.0	8.8	-0.3	-0.5	-3.0
Diabetes (mother)	2.8	3.5	6.1	-2.5	-1.8	-1.2
Severe depression (siblings)	0.5	0.6	1.3	-0.4	-0.5	-1.1
Pack years adult smoking proportion	0.1	0.2	0.3	0.5	0.2	-0.5
Impedance of leg (right)	0.5	2.3	4.0	1.3	1.1	2.0
Leg fat-free mass (left)	1.4	7.3	11.3	3.4	2.8	-1.6
Trunk fat percentage	0.4	1.5	3.4	1.1	1.8	-0.1
Hand grip strength (right)	0.8	2.1	4.5	2.1	1.3	0.5
Townsend deprivation index at recruitment	1.8	2.5	4.7	-1.6	-2.2	0.5
Current tobacco smoking	0.4	0.7	1.4	-0.1	-0.8	-1.2
Average weekly fortified wine intake	2.2	2.6	4.0	-2.0	-1.5	1.2
Maternal smoking around birth	1.1	1.6	2.5	-1.6	-1.2	-1.0
Fed-up feelings	0.6	1.1	1.5	-1.2	-1.1	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.9	-1.4	0.1	0.9
Relative age voice broke	1.9	2.9	4.3	-2.0	-2.1	0.6
Taking other prescription medications	0.6	1.0	2.7	-0.5	0.3	-1.6
Age when periods started (menarche)	2.3	5.6	11.9	1.5	1.6	3.4
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	3.2	-1.8	-1.5	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	0.6	1.1	0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.7	0.5	1.3	-0.3
Qualifications: CSEs or equivalent	1.1	1.4	2.5	-1.6	-1.3	-0.3
Serious illness, injury or assault to yourself	1.6	2.0	2.7	1.2	1.7	-1.3
High blood pressure	0.3	0.8	1.6	-1.3	-0.7	-0.5
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.6	1.3	0.9	0.4
Multivitamins +/- minerals	1.1	1.4	4.0	0.3	-0.4	-2.0
Stomach or abdominal pain in last month	1.9	2.4	3.4	-1.8	-1.8	-0.7
Supplements: Glucosamine	0.2	0.3	0.6	-0.4	-0.3	0.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	-0.6	0.1	0.5
Medication: Atenolol	2.6	3.3	8.1	-2.8	-1.2	-0.6
Medication: Levothyroxine sodium	0.8	1.4	3.4	0.6	0.6	1.8
Sitting height	2.8	19.8	40.9	6.4	4.3	-0.6
Chronic bronchitis/emphysema (father)	0.8	0.9	2.1	-1.5	-0.7	-0.1
High blood pressure (mother)	0.8	1.2	3.0	-1.7	-0.7	-0.2
Body mass index (BMI)	0.4	1.5	4.1	-0.7	0.1	-2.0
Impedance of leg (left)	0.3	1.6	3.9	0.8	0.6	2.0
Leg predicted mass (left)	1.4	7.5	11.5	3.4	2.9	-1.6
Trunk fat mass	0.7	3.0	5.2	1.9	2.3	-0.5
Waist circumference	0.5	1.9	2.9	1.0	1.7	-1.4
Number of incorrect matches in round	0.2	0.3	0.9	-1.0	-0.3	0.0
Past tobacco smoking	1.1	2.0	2.9	-1.4	-1.7	1.0
Alcohol usually taken with meals	0.8	1.2	3.1	-1.8	-0.7	-0.2
Nervous feelings	0.8	1.5	2.1	-1.5	-1.4	0.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.1	-1.8	-0.9	-1.1
Hearing difficulty/problems with background noise	0.1	0.1	0.3	-0.1	0.5	0.2
Hair/balding pattern: Pattern 2	4.8	6.0	13.5	-3.7	-2.1	0.4
Had menopause	0.4	0.5	1.3	0.4	0.4	1.1
Had other major operations	1.1	1.3	2.0	0.8	1.2	-1.4
Forced vital capacity (FVC)	1.4	5.6	11.1	3.3	2.3	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.3	0.9	1.1	0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	-0.9	-0.1	0.0
Qualifications: None of the above	0.3	0.7	1.5	-1.2	-0.8	0.2
Financial difficulties in last 2 years	2.0	2.7	5.9	-2.4	-1.3	-0.8
Mouth/teeth dental problems	1.7	2.6	5.8	2.4	1.4	0.2
Heart attack	0.9	1.1	1.6	0.5	1.2	-1.3
Allergy	0.2	0.5	0.8	-0.8	-0.3	0.9
Pain all over the body in last month	0.1	0.1	0.2	-0.4	0.1	0.0
Diabetes (self-reported)	0.8	1.3	3.3	-0.4	0.5	-1.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.6	-0.0	-0.3	-1.3
Medication: Ramipril	1.5	1.9	3.3	-1.3	-0.9	-1.8
Medication: Simvastatin	1.9	2.8	5.5	-2.3	-1.2	-1.1
Fluid intelligence score	1.6	3.3	6.8	2.6	1.7	-0.3
Illnesses of siblings	1.0	1.4	3.5	1.9	0.5	0.7
Neuroticism score	0.7	1.5	2.8	-1.7	-1.3	-0.0
Weight	1.1	5.5	7.7	2.6	2.8	-1.5
Impedance of arm (right)	0.3	1.3	3.1	0.8	0.6	1.7
Arm fat percentage (right)	0.1	0.5	0.9	-0.6	0.3	-1.0
Trunk fat-free mass	1.5	8.6	14.3	3.8	3.0	-1.5
Hip circumference	0.8	3.4	5.6	2.0	2.4	-0.8
Time employed in main current job	2.4	2.8	4.4	2.1	1.8	0.9
Alcohol intake versus 10 years previously	0.3	0.5	0.7	-0.8	-0.0	0.9
Father’s age at death	2.3	3.1	6.6	-0.4	-1.5	2.6
Worrier / anxious feelings	0.1	0.2	0.5	-0.2	0.2	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.8	-0.7	-0.4	-1.4
Falls in the last year	1.0	1.4	2.1	1.4	1.0	-1.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.4	0.5	0.1
Number of live births	0.6	0.9	1.3	-1.1	-0.8	0.9
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	6.4	2.5	1.5	0.1
Pulse rate	1.6	2.7	6.6	-1.1	-2.6	0.5
Happiness	1.4	1.7	2.7	-1.7	-1.6	0.1
Noisy workplace	3.2	3.9	6.6	-2.6	-2.2	-0.7
Qualifications: A levels/AS levels or equivalent	1.5	3.3	7.8	2.8	0.9	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	2.7	-1.5	-0.9	-1.6
Mouth/teeth dental problems: Dentures	0.5	0.8	1.8	-1.3	-0.8	0.2
Asthma	0.6	1.1	2.2	1.5	1.0	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.3	-1.1	-0.0	0.2
Medication: Cholesterol lowering	1.3	2.0	4.0	-2.0	-0.6	-1.3
Depression (self-reported)	0.3	0.4	0.9	-0.9	0.4	-0.2
Medication: Lansoprazole	0.0	0.0	0.0	-0.2	-0.1	0.0
Prospective memory result	0.5	0.7	1.8	1.4	-0.3	-0.1
Lung cancer (father)	0.9	1.1	2.6	-0.6	-0.5	1.6
Illnesses of mother	1.0	1.2	3.1	1.8	0.0	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	4.4	2.1	1.8	-0.1
Pulse wave Arterial Stiffness index	0.7	0.8	1.7	-0.8	-1.3	0.5
Impedance of arm (left)	0.6	2.6	3.5	1.4	1.6	1.9
Arm fat mass (right)	0.3	1.4	2.4	0.8	1.0	-1.5
Trunk predicted mass	1.6	8.9	14.9	3.9	3.1	-1.5
Standing height	3.0	29.6	51.7	7.2	6.0	0.8
Length of working week for main job	2.4	2.7	4.8	1.8	2.2	-0.4
Exposure to tobacco smoke at home	0.5	0.5	1.1	0.6	-0.2	-1.1
Breastfed as a baby	1.8	2.3	3.2	-1.0	-1.8	1.6
Tense / ‘highly strung’	0.0	0.0	0.0	0.1	-0.1	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	4.0	-0.6	1.2	-2.0
Hair/balding pattern: Pattern 4	0.3	0.8	2.1	0.3	1.5	-0.2
Birth weight of first child	0.3	0.6	1.3	-0.5	0.3	-1.1
Peak expiratory flow (PEF)	0.8	1.9	3.8	1.3	2.0	0.2
Pulse wave reflection index	0.3	0.3	0.9	0.0	0.9	-0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	-1.2	-0.0	0.3
Loud music exposure frequency	1.1	1.2	2.7	0.1	-1.6	-1.0
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	5.0	2.2	0.5	-0.2
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	5.9	-2.4	-1.1	-0.8
Blood clot in the leg (DVT)	1.1	1.5	1.6	-1.2	-1.3	-1.1
Medication: Paracetamol	3.7	6.1	10.5	-3.2	-1.8	-2.1
Headache pain in last month	3.0	5.2	9.1	-2.4	-0.9	-3.0
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.2	1.8	0.5	0.6
Glaucoma (self-reported)	0.2	0.3	0.5	0.3	0.5	0.7
Gout (self-reported)	1.4	1.9	5.2	-0.7	0.4	2.3
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	4.3	-0.2	1.2	2.1
Medication: Amlodipine	0.6	0.9	1.9	-0.8	-0.2	-1.4
Medication: Ventolin 100micrograms inhaler	1.2	1.6	3.5	1.9	0.9	-0.7
Birth weight	1.0	2.2	4.8	1.0	2.2	0.8
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.8	0.0	0.5	-1.3
High blood pressure (siblings)	0.7	1.1	3.2	-0.1	-0.1	-1.8
Forced vital capacity (FVC), Best measure	1.6	5.9	9.7	3.1	2.8	0.4
Body fat percentage	0.2	0.7	1.8	0.5	1.4	-0.4
Leg fat percentage (right)	0.1	0.2	0.5	0.2	0.7	-0.2
Arm fat-free mass (right)	1.6	8.2	12.8	3.6	3.2	-1.3
Exposure to tobacco smoke outside home	0.3	0.3	0.9	-0.3	-0.2	0.9
Comparative body size at age 10	0.6	1.6	2.6	-1.6	-0.6	1.3
Number of full brothers	2.5	3.1	7.0	-2.6	-1.0	-1.1
Worry too long after embarrassment	0.9	1.5	2.6	-1.1	-0.8	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	5.1	-2.3	-1.6	-1.6
Wheeze or whistling in the chest in last year	0.9	1.5	3.7	0.2	-0.9	-1.9
Number of children fathered	1.4	1.6	2.1	1.2	1.4	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.1	-0.1	0.6
Age at first live birth	0.1	0.1	0.3	0.5	-0.2	-0.1
Pulse wave peak to peak time	1.2	1.4	2.5	1.2	1.6	-0.3
Health satisfaction	2.2	2.9	4.9	-1.1	-1.6	-2.2
Shortness of breath walking on level ground	3.9	4.7	10.7	-1.5	-3.3	-1.0
Qualifications: College or University degree	2.4	7.4	10.9	3.3	3.3	0.7
Eye problems/disorders: None of the above	1.6	1.9	3.4	-1.4	-1.8	-0.5
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.8	-0.1	-0.7	-0.9
Emphysema/chronic bronchitis	2.6	2.9	7.2	1.1	0.7	-2.7
Medication for pain relief, constipation, heartburn	1.5	2.5	4.1	1.8	0.5	2.0
Neck or shoulder pain in last month	2.5	3.6	6.8	-2.6	-1.5	-1.2
Medication: Blood pressure	0.4	0.8	1.9	-1.4	-0.6	-0.3
Angina (self-reported)	1.2	1.5	3.8	-2.0	-0.5	-0.7
Migraine (self-reported)	0.5	0.6	0.8	-0.9	-0.6	-0.9
Medication: Ibuprofen	0.1	0.1	0.1	-0.2	0.2	0.3
Medication: Allopurinol	0.2	0.3	0.7	-0.8	-0.4	0.2
Medication: Omeprazole	0.5	0.6	1.2	-0.7	0.3	-1.1
Medication: Seretide 50 evohaler	0.8	0.9	1.8	0.4	0.9	1.3
Mean time to correctly identify matches	2.3	4.4	7.7	-2.8	-0.4	2.3
Heart disease (mother)	0.9	1.1	1.6	-1.2	0.5	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.2	1.1	0.9	0.8
Whole body fat mass	0.4	1.8	2.8	1.4	1.7	-0.9
Leg fat mass (right)	0.4	1.4	1.8	1.0	1.3	-1.2
Arm predicted mass (right)	1.6	7.9	12.5	3.5	3.0	-1.5
Pulse rate, automated reading	0.3	1.1	3.0	0.1	-1.7	0.6
Alcohol intake frequency.	1.0	2.3	3.4	-1.8	-0.5	-1.8
Comparative height size at age 10	5.2	28.5	47.7	6.9	6.1	-0.6
Number of full sisters	1.7	2.0	5.3	0.9	2.3	0.2
Suffer from ‘nerves’	0.4	0.7	1.3	-1.2	-0.4	0.7
Overall health rating	0.5	1.1	1.6	-1.2	-0.3	-1.3
Chest pain or discomfort	2.0	2.8	8.1	-0.6	-0.1	-2.8
Had major operations	1.3	1.5	4.4	-0.4	-0.2	-2.1
Age at last live birth	0.2	0.3	0.4	0.5	0.4	0.7
Family relationship satisfaction	0.2	0.2	0.6	-0.8	0.0	-0.2
Leg pain on walking	1.5	1.8	5.4	0.2	0.2	-2.3
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	5.5	0.3	0.2	-2.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.7	-0.8	0.1	-0.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.4	0.9	0.7	1.6
Medication: Aspirin	0.0	0.0	0.0	0.1	0.1	-0.1
Supplements: Vitamin C	1.3	1.6	2.6	-1.0	-1.1	-1.6
Knee pain experienced in last month	0.0	0.1	0.1	-0.3	0.1	-0.3
Hypertension (Self-reported)	0.2	0.6	0.9	-1.0	-0.7	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.5	0.3	-0.6	-0.7
Illnesses of father: Heart disease	0.2	0.2	0.4	-0.5	-0.2	-0.6
Illnesses of siblings: Diabetes	3.1	3.8	7.5	-2.7	-1.9	-0.2
Smoking status: Previous	0.5	0.7	1.5	0.8	1.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	4.6	2.2	1.5	-0.5
Whole body fat-free mass	1.4	8.3	13.7	3.7	3.0	-1.6
Leg fat-free mass (right)	1.1	6.0	8.6	2.9	2.4	-1.9
Arm fat percentage (left)	0.1	0.5	0.9	-0.3	0.6	-0.9
Average weekly red wine intake	0.2	0.3	0.5	0.7	0.1	0.6
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.6	-1.6	-0.6	0.2
Mood swings	0.5	0.9	2.3	-1.5	-0.2	-0.6
Loneliness, isolation	0.2	0.3	0.4	0.7	0.6	0.1
Long-standing illness, disability or infirmity	1.7	2.7	7.3	-0.4	0.7	-2.7
Ever had bowel cancer screening	0.0	0.0	0.1	0.2	-0.1	-0.3
Diabetes diagnosed by doctor	0.9	1.4	4.0	-0.5	0.2	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.7	0.0	0.8	0.9
Friendships satisfaction	0.3	0.3	0.7	-0.5	-0.8	0.2
Qualifications: nursing, teaching	1.0	1.5	1.9	1.1	1.4	-1.3
Commuting to job workplace: Walk	1.2	1.3	3.1	1.8	0.8	-0.5
Eye problems/disorders: Cataract	1.0	1.1	2.1	1.0	0.6	1.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	1.7	-1.3	-1.2	-0.5
Medication for cholesterol	1.6	2.4	4.0	2.0	1.0	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.8	-0.9	-0.1	-0.9
Back pain experienced in last month	1.0	1.4	2.3	-1.3	1.5	-0.6
Mineral and other dietary supplements	1.0	1.4	3.8	0.4	1.9	-0.4
Breast cancer (self-reported)	0.3	0.4	0.8	0.7	0.1	-0.9
Asthma (self-reported)	0.7	1.5	3.2	1.8	1.1	-0.0
Osteoporosis (self-reported)	1.1	1.4	2.3	0.2	-1.3	-1.5
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.2	-0.5	0.1
Medication: Aspirin	0.1	0.1	0.1	-0.3	-0.0	-0.4
Medication: Gliclazide	0.7	0.8	1.2	0.8	0.6	-1.1
Illnesses of father: None of the above (group 1)	1.4	1.7	2.6	1.6	1.0	1.3
Smoking status: Current	0.6	1.0	2.3	0.2	-0.7	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	3.6	1.1	-0.1	1.9
Whole body water mass	1.4	8.0	13.2	3.6	3.0	-1.4
Leg predicted mass (right)	1.0	5.5	8.0	2.8	2.3	-1.8
Arm fat mass (left)	0.4	1.7	2.1	0.9	1.5	-1.4
Number of self-reported non-cancer illnesses	0.3	0.5	1.4	-0.3	0.1	-1.2
Average weekly champagne plus white wine intake	0.2	0.3	0.9	-0.1	0.3	-0.9
Miserableness	0.9	1.6	2.4	-1.5	-0.4	-1.5
Guilty feelings	1.1	1.7	3.0	-1.7	-1.4	-0.4
Wears glasses or contact lenses	1.4	1.7	4.8	-2.2	-0.3	0.3
Ever taken oral contraceptive pill	1.5	1.7	2.3	0.8	1.5	1.5
Hearing aid user	0.4	0.4	0.7	-0.7	-0.3	-0.8
Mother’s age at death	1.0	1.2	2.9	-0.5	-0.7	1.7
Financial situation satisfaction	2.9	3.6	5.3	-2.3	-2.0	1.3
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.0	-1.4	-0.6	-0.4
Commuting to job workplace: Public transport	0.2	0.3	0.4	0.6	-0.6	0.3
Eye problems/disorders: Glaucoma	0.4	0.5	0.9	0.3	0.5	1.0
Medication: Blood pressure	0.4	0.8	1.8	-0.7	-0.5	-1.3
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.3	-1.1	0.1	-1.2
Supplements: Fish oil (including cod liver oil)	2.1	2.7	5.4	-1.6	-2.3	0.4
High cholesterol (Self-reported)	1.4	2.6	5.7	-2.4	-1.2	-0.8
Medication: Bendroflumethiazide	0.3	0.5	0.9	-0.9	-0.5	-0.7
Medication: Paracetamol	2.2	3.5	5.2	-2.1	-1.0	-2.3
Medication: Lisinopril	1.4	1.7	3.9	-1.0	-2.0	0.6
Medication: Atorvastatin	0.4	0.5	1.0	0.7	1.0	0.3
Illnesses of father: High blood pressure	0.8	1.0	1.7	-1.2	-1.3	-0.1
Alcohol drinker status: Never	0.6	0.7	2.0	-1.4	-0.2	-0.1
Ever smoked	1.5	2.6	4.2	1.8	2.0	-0.7
Basal metabolic rate	1.5	8.1	12.6	3.5	3.0	-1.6
Leg fat percentage (left)	0.0	0.1	0.1	-0.3	0.3	-0.4
Arm fat-free mass (left)	1.4	7.1	10.9	3.3	2.9	-1.4
Number of operations (self-reported)	1.6	2.4	6.2	-0.9	-0.4	-2.5
Average weekly beer plus cider intake	0.3	0.4	0.7	0.8	0.6	0.3
Irritability	2.4	4.1	8.9	1.8	3.0	0.5
Risk taking	1.6	2.4	3.6	1.9	0.2	-1.8
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.5	-1.6	-0.7	-0.1
Fractured/broken bones in last 5 years	1.7	2.1	2.6	1.5	1.6	-1.2
Age started oral contraceptive pill	2.1	2.6	7.1	0.9	-0.3	2.7
Diastolic blood pressure, automated reading	0.1	0.3	0.8	-0.3	-0.9	-0.1
Ever depressed for a whole week	0.3	0.4	0.8	-0.9	0.6	-0.2
Unable to work because of sickness or disability	0.1	0.1	0.3	-0.5	-0.1	-0.4
Commuting to job workplace: Cycle	0.5	0.6	1.2	-0.3	-1.1	-0.7
Myopia	1.9	2.7	5.8	-2.4	-1.5	0.3
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.3	1.1	0.2	0.9
Cholesterol lowering medication	1.1	1.7	3.0	-1.7	-1.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.7	0.1	0.9	-0.4
Pain experienced in last month	2.0	3.4	7.9	2.8	1.2	0.9
Supplements: Calcium	0.3	0.3	0.6	0.5	-0.2	0.7
Basal cell carcinoma (self-reported)	0.6	0.7	1.1	-1.1	-0.8	-0.6
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.5	0.2	0.9	-1.2
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	3.4	-1.7	-1.8	-1.3
Heart disease (siblings)	2.9	3.6	7.9	-2.8	-1.7	0.3
Alcohol drinker status: Previous	2.0	2.3	4.4	1.5	2.1	-0.2
Pack years of smoking	0.2	0.3	0.5	0.7	0.6	-0.2
Impedance of whole body	0.4	2.2	4.5	1.1	1.0	2.1
Leg fat mass (left)	0.3	1.1	1.4	0.8	1.1	-1.2
Arm predicted mass (left)	1.4	7.3	11.0	3.3	2.9	-1.5