TWAS hub - GPC5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.276	0.0370	0.0e+00	0.180	0.192	0.246	0.270	0.265	2.3e-21	7.3e-23	1.2e-29	6.6e-33	3.8e-32
2	ROSMAP	Brain Pre-frontal Cortex	0.260	0.0412	8.9e-12	0.081	0.114	0.115	0.113	0.103	1.4e-10	1.8e-14	1.4e-14	2.8e-14	4.0e-13
3	TCGA	Pancreatic Adenocarcinoma	0.165	0.0630	5.4e-03	-0.005	0.020	0.035	NA	0.011	5.6e-01	5.0e-02	1.4e-02	NA	1.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Comparative height size at age 10	5.2	28.5	47.7	6.9	6.1	-0.6
Hair/balding pattern: Pattern 2	4.8	6.0	13.5	-3.7	-2.1	0.4
Shortness of breath walking on level ground	3.9	4.7	10.7	-1.5	-3.3	-1.0
Alzheimer’s Disease (in father)	3.8	4.1	5.9	-2.4	-0.9	-2.4
Medication: Paracetamol	3.7	6.1	10.5	-3.2	-1.8	-2.1
Height	3.3	64.4	114.5	10.7	8.8	0.7
Noisy workplace	3.2	3.9	6.6	-2.6	-2.2	-0.7
Illnesses of siblings: Diabetes	3.1	3.8	7.5	-2.7	-1.9	-0.2
Standing height	3.0	29.6	51.7	7.2	6.0	0.8
Headache pain in last month	3.0	5.2	9.1	-2.4	-0.9	-3.0
Financial situation satisfaction	2.9	3.6	5.3	-2.3	-2.0	1.3
Heart disease (siblings)	2.9	3.6	7.9	-2.8	-1.7	0.3
Diabetes (mother)	2.8	3.5	6.1	-2.5	-1.8	-1.2
Sitting height	2.8	19.8	40.9	6.4	4.3	-0.6
Medication: Atenolol	2.6	3.3	8.1	-2.8	-1.2	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	5.1	-2.3	-1.6	-1.6
Emphysema/chronic bronchitis	2.6	2.9	7.2	1.1	0.7	-2.7
Alzheimer’s Disease (in mother)	2.5	2.9	4.2	2.1	1.9	-0.9
Diabetes (father)	2.5	3.0	8.8	-0.3	-0.5	-3.0
Number of full brothers	2.5	3.1	7.0	-2.6	-1.0	-1.1
Neck or shoulder pain in last month	2.5	3.6	6.8	-2.6	-1.5	-1.2
Time employed in main current job	2.4	2.8	4.4	2.1	1.8	0.9
Length of working week for main job	2.4	2.7	4.8	1.8	2.2	-0.4
Qualifications: College or University degree	2.4	7.4	10.9	3.3	3.3	0.7
Irritability	2.4	4.1	8.9	1.8	3.0	0.5
Age when periods started (menarche)	2.3	5.6	11.9	1.5	1.6	3.4
Father’s age at death	2.3	3.1	6.6	-0.4	-1.5	2.6
Mean time to correctly identify matches	2.3	4.4	7.7	-2.8	-0.4	2.3
Average weekly fortified wine intake	2.2	2.6	4.0	-2.0	-1.5	1.2
Health satisfaction	2.2	2.9	4.9	-1.1	-1.6	-2.2
Medication: Paracetamol	2.2	3.5	5.2	-2.1	-1.0	-2.3
Medication: Co-codamol	2.1	2.5	3.4	-1.8	-1.6	-1.1
Supplements: Fish oil (including cod liver oil)	2.1	2.7	5.4	-1.6	-2.3	0.4
Age started oral contraceptive pill	2.1	2.6	7.1	0.9	-0.3	2.7
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	3.4	-1.7	-1.8	-1.3
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	3.2	-1.8	-1.5	-1.2
Financial difficulties in last 2 years	2.0	2.7	5.9	-2.4	-1.3	-0.8
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	5.9	-2.4	-1.1	-0.8
Chest pain or discomfort	2.0	2.8	8.1	-0.6	-0.1	-2.8
Pain experienced in last month	2.0	3.4	7.9	2.8	1.2	0.9
Alcohol drinker status: Previous	2.0	2.3	4.4	1.5	2.1	-0.2
Reaction Time	1.9	3.7	6.1	-2.5	-0.6	2.1
Relative age voice broke	1.9	2.9	4.3	-2.0	-2.1	0.6
Stomach or abdominal pain in last month	1.9	2.4	3.4	-1.8	-1.8	-0.7
Medication: Simvastatin	1.9	2.8	5.5	-2.3	-1.2	-1.1
Myopia	1.9	2.7	5.8	-2.4	-1.5	0.3
Alzheimer’s Disease (including proxy)	1.8	2.6	3.5	1.2	1.9	-1.7
Ulcerative Colitis	1.8	2.6	3.8	-1.5	-1.9	-1.4
Townsend deprivation index at recruitment	1.8	2.5	4.7	-1.6	-2.2	0.5
Breastfed as a baby	1.8	2.3	3.2	-1.0	-1.8	1.6
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	2.1	-1.3	-1.4	-1.4
Mouth/teeth dental problems	1.7	2.6	5.8	2.4	1.4	0.2
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	2.7	-1.5	-0.9	-1.6
Number of full sisters	1.7	2.0	5.3	0.9	2.3	0.2
Long-standing illness, disability or infirmity	1.7	2.7	7.3	-0.4	0.7	-2.7
Fractured/broken bones in last 5 years	1.7	2.1	2.6	1.5	1.6	-1.2
Average weekly spirits intake	1.6	2.0	3.0	1.7	1.1	1.3
Serious illness, injury or assault to yourself	1.6	2.0	2.7	1.2	1.7	-1.3
Fluid intelligence score	1.6	3.3	6.8	2.6	1.7	-0.3
Pulse rate	1.6	2.7	6.6	-1.1	-2.6	0.5
Trunk predicted mass	1.6	8.9	14.9	3.9	3.1	-1.5
Forced vital capacity (FVC), Best measure	1.6	5.9	9.7	3.1	2.8	0.4
Arm fat-free mass (right)	1.6	8.2	12.8	3.6	3.2	-1.3
Eye problems/disorders: None of the above	1.6	1.9	3.4	-1.4	-1.8	-0.5
Arm predicted mass (right)	1.6	7.9	12.5	3.5	3.0	-1.5
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	5.5	0.3	0.2	-2.3
Medication for cholesterol	1.6	2.4	4.0	2.0	1.0	1.5
Number of operations (self-reported)	1.6	2.4	6.2	-0.9	-0.4	-2.5
Risk taking	1.6	2.4	3.6	1.9	0.2	-1.8
Relative age of first facial hair	1.5	3.1	4.6	-2.0	-2.1	-0.8
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	2.9	-1.4	-1.0	-1.7
Medication: Metformin	1.5	2.1	6.1	-0.1	0.4	-2.5
Medication: Ramipril	1.5	1.9	3.3	-1.3	-0.9	-1.8
Trunk fat-free mass	1.5	8.6	14.3	3.8	3.0	-1.5
Qualifications: A levels/AS levels or equivalent	1.5	3.3	7.8	2.8	0.9	-1.2
Medication for pain relief, constipation, heartburn	1.5	2.5	4.1	1.8	0.5	2.0
Leg pain on walking	1.5	1.8	5.4	0.2	0.2	-2.3
Ever taken oral contraceptive pill	1.5	1.7	2.3	0.8	1.5	1.5
Ever smoked	1.5	2.6	4.2	1.8	2.0	-0.7
Basal metabolic rate	1.5	8.1	12.6	3.5	3.0	-1.6
Ulcerative Colitis (UC)	1.4	2.6	4.0	-2.0	-1.8	-0.8
Fasting Glucose	1.4	1.7	3.8	1.9	1.1	0.1
Type 2 Diabetes (T2D) (2018)	1.4	2.7	7.6	0.2	0.7	-2.8
Sensitivity / hurt feelings	1.4	2.4	4.1	-2.0	-1.1	1.4
Leg fat-free mass (left)	1.4	7.3	11.3	3.4	2.8	-1.6
Leg predicted mass (left)	1.4	7.5	11.5	3.4	2.9	-1.6
Forced vital capacity (FVC)	1.4	5.6	11.1	3.3	2.3	0.6
Happiness	1.4	1.7	2.7	-1.7	-1.6	0.1
Gout (self-reported)	1.4	1.9	5.2	-0.7	0.4	2.3
Number of children fathered	1.4	1.6	2.1	1.2	1.4	-1.1
Whole body fat-free mass	1.4	8.3	13.7	3.7	3.0	-1.6
Illnesses of father: None of the above (group 1)	1.4	1.7	2.6	1.6	1.0	1.3
Whole body water mass	1.4	8.0	13.2	3.6	3.0	-1.4
Wears glasses or contact lenses	1.4	1.7	4.8	-2.2	-0.3	0.3
High cholesterol (Self-reported)	1.4	2.6	5.7	-2.4	-1.2	-0.8
Medication: Lisinopril	1.4	1.7	3.9	-1.0	-2.0	0.6
Arm fat-free mass (left)	1.4	7.1	10.9	3.3	2.9	-1.4
Arm predicted mass (left)	1.4	7.3	11.0	3.3	2.9	-1.5
Ever used hormone-replacement therapy (HRT)	1.3	1.6	3.1	-0.4	1.2	-1.8
Angina	1.3	1.7	4.2	-2.0	-0.5	-0.8
Medication: Cholesterol lowering	1.3	2.0	4.0	-2.0	-0.6	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	4.0	-0.6	1.2	-2.0
Had major operations	1.3	1.5	4.4	-0.4	-0.2	-2.1
Supplements: Vitamin C	1.3	1.6	2.6	-1.0	-1.1	-1.6
HDL Cholesterol	1.2	2.0	2.2	-1.3	-1.5	-1.4
Ever had hysterectomy (womb removed)	1.2	1.3	3.5	-1.9	-0.3	-0.6
Medication: Ventolin 100micrograms inhaler	1.2	1.6	3.5	1.9	0.9	-0.7
Pulse wave peak to peak time	1.2	1.4	2.5	1.2	1.6	-0.3
Angina (self-reported)	1.2	1.5	3.8	-2.0	-0.5	-0.7
Commuting to job workplace: Walk	1.2	1.3	3.1	1.8	0.8	-0.5
Bipolar Disorder (2011)	1.1	1.0	1.6	0.2	1.3	1.2
Hand grip strength (left)	1.1	3.0	6.8	2.6	1.4	0.5
Maternal smoking around birth	1.1	1.6	2.5	-1.6	-1.2	-1.0
Qualifications: CSEs or equivalent	1.1	1.4	2.5	-1.6	-1.3	-0.3
Multivitamins +/- minerals	1.1	1.4	4.0	0.3	-0.4	-2.0
Past tobacco smoking	1.1	2.0	2.9	-1.4	-1.7	1.0
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.1	-1.8	-0.9	-1.1
Had other major operations	1.1	1.3	2.0	0.8	1.2	-1.4
Weight	1.1	5.5	7.7	2.6	2.8	-1.5
Loud music exposure frequency	1.1	1.2	2.7	0.1	-1.6	-1.0
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	5.0	2.2	0.5	-0.2
Blood clot in the leg (DVT)	1.1	1.5	1.6	-1.2	-1.3	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	4.6	2.2	1.5	-0.5
Leg fat-free mass (right)	1.1	6.0	8.6	2.9	2.4	-1.9
Osteoporosis (self-reported)	1.1	1.4	2.3	0.2	-1.3	-1.5
Guilty feelings	1.1	1.7	3.0	-1.7	-1.4	-0.4
Cholesterol lowering medication	1.1	1.7	3.0	-1.7	-1.4	-0.4
Verbal and Numeric Reasoning (VNR)	1.0	2.3	5.9	2.4	1.0	0.1
Cardiovascular Disease	1.0	3.4	4.7	-2.2	-2.0	-1.3
Illnesses of siblings	1.0	1.4	3.5	1.9	0.5	0.7
Falls in the last year	1.0	1.4	2.1	1.4	1.0	-1.1
Illnesses of mother	1.0	1.2	3.1	1.8	0.0	0.7
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	4.3	-0.2	1.2	2.1
Birth weight	1.0	2.2	4.8	1.0	2.2	0.8
Alcohol intake frequency.	1.0	2.3	3.4	-1.8	-0.5	-1.8
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.4	0.9	0.7	1.6
Qualifications: nursing, teaching	1.0	1.5	1.9	1.1	1.4	-1.3
Eye problems/disorders: Cataract	1.0	1.1	2.1	1.0	0.6	1.4
Back pain experienced in last month	1.0	1.4	2.3	-1.3	1.5	-0.6
Mineral and other dietary supplements	1.0	1.4	3.8	0.4	1.9	-0.4
Leg predicted mass (right)	1.0	5.5	8.0	2.8	2.3	-1.8
Mother’s age at death	1.0	1.2	2.9	-0.5	-0.7	1.7
Irritable Bowel Disease (IBD)	0.9	2.1	4.2	-2.1	-1.4	-0.2
Coronary Artery Disease (CAD)	0.9	1.1	1.9	-0.8	-0.9	1.4
Respiratory disease	0.9	2.1	3.3	1.8	1.5	-0.7
Heart attack	0.9	1.1	1.6	0.5	1.2	-1.3
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	6.4	2.5	1.5	0.1
Lung cancer (father)	0.9	1.1	2.6	-0.6	-0.5	1.6
Worry too long after embarrassment	0.9	1.5	2.6	-1.1	-0.8	1.6
Wheeze or whistling in the chest in last year	0.9	1.5	3.7	0.2	-0.9	-1.9
Heart disease (mother)	0.9	1.1	1.6	-1.2	0.5	1.3
Diabetes diagnosed by doctor	0.9	1.4	4.0	-0.5	0.2	-2.0
Miserableness	0.9	1.6	2.4	-1.5	-0.4	-1.5
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.5	-1.6	-0.7	-0.1
Breast Cancer	0.8	1.9	3.9	-2.0	-1.0	-0.9
Age at First Birth	0.8	1.2	2.7	0.5	-0.8	1.6
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.8	-1.7	-0.6	0.2
Hand grip strength (right)	0.8	2.1	4.5	2.1	1.3	0.5
Medication: Levothyroxine sodium	0.8	1.4	3.4	0.6	0.6	1.8
Chronic bronchitis/emphysema (father)	0.8	0.9	2.1	-1.5	-0.7	-0.1
High blood pressure (mother)	0.8	1.2	3.0	-1.7	-0.7	-0.2
Alcohol usually taken with meals	0.8	1.2	3.1	-1.8	-0.7	-0.2
Nervous feelings	0.8	1.5	2.1	-1.5	-1.4	0.8
Diabetes (self-reported)	0.8	1.3	3.3	-0.4	0.5	-1.8
Hip circumference	0.8	3.4	5.6	2.0	2.4	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	4.4	2.1	1.8	-0.1
Peak expiratory flow (PEF)	0.8	1.9	3.8	1.3	2.0	0.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.2	1.8	0.5	0.6
Medication: Seretide 50 evohaler	0.8	0.9	1.8	0.4	0.9	1.3
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.6	-1.6	-0.6	0.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.0	-1.4	-0.6	-0.4
Illnesses of father: High blood pressure	0.8	1.0	1.7	-1.2	-1.3	-0.1
Intelligence (Savage-Jansen 2018)	0.7	2.0	5.4	2.3	-0.1	0.8
Ovarian Cancer	0.7	0.9	1.4	1.2	1.1	-0.2
Smoking Status	0.7	1.7	2.9	1.4	0.5	-1.7
Allergy or Eczema	0.7	2.0	4.9	2.2	0.9	0.4
Hearing difficulty/problems: Yes	0.7	1.1	2.2	-1.5	-0.6	-0.9
Medication for hormone replacement therapy	0.7	0.7	1.2	-0.7	0.7	-1.1
Vitamin and mineral supplements	0.7	1.0	2.8	-0.4	0.2	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.9	-1.4	0.1	0.9
Trunk fat mass	0.7	3.0	5.2	1.9	2.3	-0.5
Neuroticism score	0.7	1.5	2.8	-1.7	-1.3	-0.0
Pulse wave Arterial Stiffness index	0.7	0.8	1.7	-0.8	-1.3	0.5
High blood pressure (siblings)	0.7	1.1	3.2	-0.1	-0.1	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.2	1.1	0.9	0.8
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	1.7	-1.3	-1.2	-0.5
Asthma (self-reported)	0.7	1.5	3.2	1.8	1.1	-0.0
Medication: Gliclazide	0.7	0.8	1.2	0.8	0.6	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	3.6	1.1	-0.1	1.9
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.3	-1.1	0.1	-1.2
Prostate Cancer	0.6	0.9	1.2	1.0	1.1	-0.7
Mean Putamen Volume	0.6	0.6	1.0	-0.9	-0.3	-1.0
BMI	0.6	3.5	5.8	-2.4	-1.0	-1.9
Fed-up feelings	0.6	1.1	1.5	-1.2	-1.1	0.7
Taking other prescription medications	0.6	1.0	2.7	-0.5	0.3	-1.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.7	0.5	1.3	-0.3
Number of live births	0.6	0.9	1.3	-1.1	-0.8	0.9
Asthma	0.6	1.1	2.2	1.5	1.0	-0.3
Impedance of arm (left)	0.6	2.6	3.5	1.4	1.6	1.9
Medication: Amlodipine	0.6	0.9	1.9	-0.8	-0.2	-1.4
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.8	0.0	0.5	-1.3
Comparative body size at age 10	0.6	1.6	2.6	-1.6	-0.6	1.3
Smoking status: Current	0.6	1.0	2.3	0.2	-0.7	-1.5
Alcohol drinker status: Never	0.6	0.7	2.0	-1.4	-0.2	-0.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.1	-1.1	-0.8	-0.6
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.5	0.2	0.9	-1.2
Depression (Nagel 2018)	0.5	0.8	1.8	-1.3	-0.2	0.8
HbA1C	0.5	0.6	1.1	0.1	-1.0	-0.8
Schizophrenia (2014)	0.5	1.1	2.3	-1.5	0.4	0.9
Hypothyroidism (self reported)	0.5	1.2	2.6	-0.6	0.9	1.6
Neuroticism	0.5	1.1	1.9	-1.2	-1.4	0.3
Chronotype (morning person)	0.5	1.1	2.8	-0.6	-0.3	-1.7
Number of treatments/medications taken	0.5	0.8	1.6	-0.9	0.2	-1.3
Supplements: Zinc	0.5	0.5	1.1	0.5	-0.5	1.1
Severe depression (siblings)	0.5	0.6	1.3	-0.4	-0.5	-1.1
Impedance of leg (right)	0.5	2.3	4.0	1.3	1.1	2.0
Waist circumference	0.5	1.9	2.9	1.0	1.7	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.8	-0.7	-0.4	-1.4
Mouth/teeth dental problems: Dentures	0.5	0.8	1.8	-1.3	-0.8	0.2
Prospective memory result	0.5	0.7	1.8	1.4	-0.3	-0.1
Exposure to tobacco smoke at home	0.5	0.5	1.1	0.6	-0.2	-1.1
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	-1.2	-0.0	0.3
Migraine (self-reported)	0.5	0.6	0.8	-0.9	-0.6	-0.9
Medication: Omeprazole	0.5	0.6	1.2	-0.7	0.3	-1.1
Overall health rating	0.5	1.1	1.6	-1.2	-0.3	-1.3
Smoking status: Previous	0.5	0.7	1.5	0.8	1.2	-0.0
Mood swings	0.5	0.9	2.3	-1.5	-0.2	-0.6
Commuting to job workplace: Cycle	0.5	0.6	1.2	-0.3	-1.1	-0.7
Crohns Disease (2017)	0.4	0.8	1.8	-1.3	-0.3	0.7
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.8	-0.9	-0.3	-0.6
Blood White Count	0.4	2.9	4.6	-1.0	-1.7	-2.1
Trunk fat percentage	0.4	1.5	3.4	1.1	1.8	-0.1
Current tobacco smoking	0.4	0.7	1.4	-0.1	-0.8	-1.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.6	1.3	0.9	0.4
Body mass index (BMI)	0.4	1.5	4.1	-0.7	0.1	-2.0
Had menopause	0.4	0.5	1.3	0.4	0.4	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.3	0.9	1.1	0.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.6	-0.0	-0.3	-1.3
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.8	-0.1	-0.7	-0.9
Medication: Blood pressure	0.4	0.8	1.9	-1.4	-0.6	-0.3
Whole body fat mass	0.4	1.8	2.8	1.4	1.7	-0.9
Leg fat mass (right)	0.4	1.4	1.8	1.0	1.3	-1.2
Suffer from ‘nerves’	0.4	0.7	1.3	-1.2	-0.4	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.7	0.0	0.8	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.8	-0.9	-0.1	-0.9
Arm fat mass (left)	0.4	1.7	2.1	0.9	1.5	-1.4
Hearing aid user	0.4	0.4	0.7	-0.7	-0.3	-0.8
Eye problems/disorders: Glaucoma	0.4	0.5	0.9	0.3	0.5	1.0
Medication: Blood pressure	0.4	0.8	1.8	-0.7	-0.5	-1.3
Medication: Atorvastatin	0.4	0.5	1.0	0.7	1.0	0.3
Impedance of whole body	0.4	2.2	4.5	1.1	1.0	2.1
Bipolar Disorder (2018)	0.3	0.5	0.7	0.5	0.6	0.8
Bipolar Disorder or Schizophrenia	0.3	0.8	1.3	-0.3	0.9	1.1
Schizophrenia (2018)	0.3	0.5	0.7	-0.8	0.5	0.8
Worry (Nagel 2018)	0.3	0.6	1.7	-0.2	-0.1	1.3
Major Depression (MDD)	0.3	0.4	1.2	-1.1	0.1	0.2
Body Mass Index (BMI) (2010)	0.3	0.5	1.0	-0.6	-0.2	-1.0
Crohns Disease (2012)	0.3	0.5	0.9	-0.7	-0.3	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	0.6	1.1	0.8
High blood pressure	0.3	0.8	1.6	-1.3	-0.7	-0.5
Impedance of leg (left)	0.3	1.6	3.9	0.8	0.6	2.0
Qualifications: None of the above	0.3	0.7	1.5	-1.2	-0.8	0.2
Impedance of arm (right)	0.3	1.3	3.1	0.8	0.6	1.7
Alcohol intake versus 10 years previously	0.3	0.5	0.7	-0.8	-0.0	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.3	-1.1	-0.0	0.2
Depression (self-reported)	0.3	0.4	0.9	-0.9	0.4	-0.2
Arm fat mass (right)	0.3	1.4	2.4	0.8	1.0	-1.5
Hair/balding pattern: Pattern 4	0.3	0.8	2.1	0.3	1.5	-0.2
Birth weight of first child	0.3	0.6	1.3	-0.5	0.3	-1.1
Pulse wave reflection index	0.3	0.3	0.9	0.0	0.9	-0.3
Exposure to tobacco smoke outside home	0.3	0.3	0.9	-0.3	-0.2	0.9
Pulse rate, automated reading	0.3	1.1	3.0	0.1	-1.7	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.5	0.3	-0.6	-0.7
Friendships satisfaction	0.3	0.3	0.7	-0.5	-0.8	0.2
Breast cancer (self-reported)	0.3	0.4	0.8	0.7	0.1	-0.9
Number of self-reported non-cancer illnesses	0.3	0.5	1.4	-0.3	0.1	-1.2
Medication: Bendroflumethiazide	0.3	0.5	0.9	-0.9	-0.5	-0.7
Average weekly beer plus cider intake	0.3	0.4	0.7	0.8	0.6	0.3
Ever depressed for a whole week	0.3	0.4	0.8	-0.9	0.6	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.3	1.1	0.2	0.9
Supplements: Calcium	0.3	0.3	0.6	0.5	-0.2	0.7
Leg fat mass (left)	0.3	1.1	1.4	0.8	1.1	-1.2
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.7	-0.3	-0.5
LDL Cholesterol	0.2	0.4	0.6	0.7	0.3	0.8
Neuroticism (2016)	0.2	0.2	0.4	-0.5	0.6	0.3
Rheumatoid Arthritis	0.2	0.3	0.4	-0.5	0.5	-0.6
Triglycerides	0.2	0.4	0.9	0.9	0.2	0.5
Blood Red Count	0.2	1.6	4.0	-0.7	-2.0	-0.6
Waist Hip Ratio (WHR)	0.2	0.7	1.7	0.3	-0.5	-1.3
Lung FVC	0.2	1.2	3.5	-0.1	-0.1	1.9
Tanning	0.2	2.7	7.2	-0.9	-0.3	-2.7
Systolic blood pressure, automated reading	0.2	0.5	1.1	1.1	0.4	0.4
Supplements: Glucosamine	0.2	0.3	0.6	-0.4	-0.3	0.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	-0.6	0.1	0.5
Number of incorrect matches in round	0.2	0.3	0.9	-1.0	-0.3	0.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	-0.9	-0.1	0.0
Allergy	0.2	0.5	0.8	-0.8	-0.3	0.9
Glaucoma (self-reported)	0.2	0.3	0.5	0.3	0.5	0.7
Body fat percentage	0.2	0.7	1.8	0.5	1.4	-0.4
Medication: Allopurinol	0.2	0.3	0.7	-0.8	-0.4	0.2
Age at last live birth	0.2	0.3	0.4	0.5	0.4	0.7
Family relationship satisfaction	0.2	0.2	0.6	-0.8	0.0	-0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.7	-0.8	0.1	-0.3
Hypertension (Self-reported)	0.2	0.6	0.9	-1.0	-0.7	-0.6
Illnesses of father: Heart disease	0.2	0.2	0.4	-0.5	-0.2	-0.6
Average weekly red wine intake	0.2	0.3	0.5	0.7	0.1	0.6
Loneliness, isolation	0.2	0.3	0.4	0.7	0.6	0.1
Average weekly champagne plus white wine intake	0.2	0.3	0.9	-0.1	0.3	-0.9
Commuting to job workplace: Public transport	0.2	0.3	0.4	0.6	-0.6	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.7	0.1	0.9	-0.4
Pack years of smoking	0.2	0.3	0.5	0.7	0.6	-0.2
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.3	-0.0	-0.6
Neuroticism (Nagel 2018)	0.1	0.3	0.8	-0.2	-0.1	0.9
Lupus	0.1	0.2	0.3	-0.1	-0.6	-0.5
Primary Biliary Cirrhosis	0.1	0.2	0.3	0.2	0.5	0.5
Blood Platelet Count	0.1	1.1	2.1	1.5	-0.9	0.5
Systolic Blood Pressure	0.1	0.3	0.6	0.6	-0.8	0.2
Lung FEV1/FVC ratio	0.1	0.7	1.7	-0.3	-0.5	-1.3
Pack years adult smoking proportion	0.1	0.2	0.3	0.5	0.2	-0.5
Hearing difficulty/problems with background noise	0.1	0.1	0.3	-0.1	0.5	0.2
Pain all over the body in last month	0.1	0.1	0.2	-0.4	0.1	0.0
Arm fat percentage (right)	0.1	0.5	0.9	-0.6	0.3	-1.0
Worrier / anxious feelings	0.1	0.2	0.5	-0.2	0.2	0.7
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.4	0.5	0.1
Leg fat percentage (right)	0.1	0.2	0.5	0.2	0.7	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.1	-0.1	0.6
Age at first live birth	0.1	0.1	0.3	0.5	-0.2	-0.1
Medication: Ibuprofen	0.1	0.1	0.1	-0.2	0.2	0.3
Arm fat percentage (left)	0.1	0.5	0.9	-0.3	0.6	-0.9
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.2	-0.5	0.1
Medication: Aspirin	0.1	0.1	0.1	-0.3	-0.0	-0.4
Diastolic blood pressure, automated reading	0.1	0.3	0.8	-0.3	-0.9	-0.1
Unable to work because of sickness or disability	0.1	0.1	0.3	-0.5	-0.1	-0.4
Blood Eosinophil Count	0.0	0.4	0.6	0.8	0.4	-0.6
Heel T-Score	0.0	0.2	0.4	-0.3	-0.6	-0.3
Hair Pigment	0.0	1.0	1.9	-0.7	0.7	1.4
Medication: Lansoprazole	0.0	0.0	0.0	-0.2	-0.1	0.0
Tense / ‘highly strung’	0.0	0.0	0.0	0.1	-0.1	0.2
Medication: Aspirin	0.0	0.0	0.0	0.1	0.1	-0.1
Knee pain experienced in last month	0.0	0.1	0.1	-0.3	0.1	-0.3
Ever had bowel cancer screening	0.0	0.0	0.1	0.2	-0.1	-0.3
Leg fat percentage (left)	0.0	0.1	0.1	-0.3	0.3	-0.4

Hub : Genes

GPC5

Models

Trait associations