Hub : Genes

GPR116

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cortex	0.3120	0.1110	0.00670	0.004	NA	-0.007	NA	0.002	2.4e-01	NA	5.6e-01	NA	2.7e-01
2	TCGA	Breast Invasive Carcinoma	0.0391	0.0157	0.00031	0.030	0.023	0.018	NA	0.022	6.8e-07	1.1e-05	9.4e-05	NA	1.8e-05
3	TCGA	Brain Lower Grade Glioma	0.0700	0.0347	0.00830	0.010	0.012	0.006	NA	0.005	2.1e-02	1.5e-02	5.7e-02	NA	7.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.7	1.2	2.4	-0.2	1.0	1.5
Bipolar Disorder or Schizophrenia	0.4	0.9	2.1	-0.1	-0.8	-1.5
Depressed Affect (Nagel 2018)	0.1	0.3	0.8	-0.9	-0.1	-0.0
Depression (Nagel 2018)	0.6	0.9	1.7	-0.7	-0.9	-1.3
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	-0.2	-0.4	0.7
Neuroticism (Nagel 2018)	0.9	2.1	5.5	-2.3	-0.4	0.8
Schizophrenia (2018)	2.1	4.3	9.6	0.0	-1.8	-3.1
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.4	-0.1	-0.2
Worry (Nagel 2018)	1.5	3.2	5.6	-2.4	1.1	1.7
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	1.2	0.5	0.6
Alzheimer’s Disease (in father)	0.9	1.0	2.9	-0.2	0.3	1.7
Alzheimer’s Disease (including proxy)	0.9	1.3	3.7	0.5	-0.2	1.9
Crohns Disease (2017)	0.3	0.7	1.1	-0.4	-1.0	1.1
Irritable Bowel Disease (IBD)	0.6	1.4	3.4	0.3	-0.8	1.8
Ulcerative Colitis (UC)	0.6	1.1	2.8	0.1	-0.6	1.7
Major Depression (MDD)	0.4	0.5	0.8	-0.8	0.9	-0.1
Reaction Time	2.1	4.0	6.9	-1.5	1.8	2.6
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.4	-1.0	-0.0	1.2
Breast Cancer	1.3	3.2	5.1	0.3	2.1	2.3
Ovarian Cancer	0.3	0.4	1.0	-1.0	0.3	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.5	0.7	1.0	1.0	-1.0	-0.4
Bipolar Disorder (2011)	0.7	0.7	1.1	1.0	0.1	-1.0
Body Mass Index (BMI) (2010)	1.5	2.0	3.6	0.9	-1.3	-1.9
Coronary Artery Disease (CAD)	0.2	0.2	0.3	0.6	0.5	0.2
Crohns Disease (2012)	0.3	0.5	1.3	-0.5	-0.1	1.2
Mean Putamen Volume	2.5	2.8	4.3	-1.6	1.2	2.1
Fasting Glucose	0.7	0.8	1.0	0.8	-0.9	-1.0
HbA1C	2.7	3.0	6.5	2.5	0.1	1.5
HDL Cholesterol	0.3	0.5	0.7	-0.6	-0.8	-0.6
LDL Cholesterol	0.3	0.5	1.4	0.3	-0.1	-1.2
Lupus	0.3	0.5	1.2	0.3	-0.5	1.1
Neuroticism (2016)	3.1	4.4	9.2	-3.0	-1.8	1.0
Primary Biliary Cirrhosis	0.5	0.7	1.5	-0.6	1.2	0.1
Rheumatoid Arthritis	1.4	2.0	4.9	0.9	-2.2	-0.4
Schizophrenia (2014)	0.7	1.6	3.5	-0.9	-0.7	-1.9
Triglycerides	0.5	0.8	1.1	1.1	0.9	-0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.5	-0.5	0.3	-0.7
Ulcerative Colitis	0.7	0.9	2.4	0.6	-0.3	1.6
Blood Eosinophil Count	0.5	3.5	6.9	1.4	1.3	2.6
Blood Platelet Count	0.5	6.0	7.0	-2.5	-2.2	-2.6
Blood Red Count	0.1	0.5	0.9	0.9	0.1	0.8
Blood White Count	1.4	10.4	30.3	-0.5	-0.8	5.5
Heel T-Score	0.0	0.2	0.3	0.5	-0.1	0.4
BMI	0.5	2.7	7.0	2.6	-1.1	0.1
Height	0.1	2.0	3.4	0.2	1.9	1.6
Waist Hip Ratio (WHR)	1.6	7.1	11.6	1.6	2.7	3.4
Systolic Blood Pressure	0.3	1.5	3.8	-2.0	-0.5	0.6
Smoking Status	0.0	0.1	0.2	-0.3	0.2	-0.4
Allergy or Eczema	0.1	0.2	0.4	0.2	0.1	0.7
Cardiovascular Disease	0.1	0.2	0.2	0.4	0.4	-0.4
Hypothyroidism (self reported)	0.6	1.3	2.0	1.4	1.1	-0.9
Respiratory disease	0.5	1.0	1.8	-0.5	1.0	-1.3
Type 2 Diabetes (T2D) (2018)	1.5	2.8	6.8	2.6	1.3	-0.3
Lung FEV1/FVC ratio	1.3	6.7	19.1	4.4	0.8	-0.6
Lung FVC	0.1	0.5	1.2	-1.1	-0.5	0.1
Neuroticism	0.5	1.2	2.0	-1.4	0.4	1.1
Chronotype (morning person)	0.5	1.2	2.7	1.6	0.1	-1.0
Hair Pigment	0.0	0.4	0.9	-0.3	-0.9	-0.3
Tanning	0.2	1.8	2.7	-1.5	-0.8	-1.6
Hand grip strength (left)	0.2	0.6	1.0	-0.8	1.0	0.3
Number of treatments/medications taken	0.3	0.6	1.8	-0.2	1.3	-0.2
Average weekly spirits intake	0.3	0.4	0.8	-0.7	-0.9	0.0
Sensitivity / hurt feelings	0.5	0.8	1.8	-1.4	-0.7	0.1
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.0	-1.3	-1.4	-0.4
Hearing difficulty/problems: Yes	1.0	1.5	3.6	-0.6	-1.9	0.7
Relative age of first facial hair	0.4	0.9	1.6	0.2	1.3	-1.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.8	0.7	1.3	-0.2
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.6	-0.5	0.5	-1.6
Ever had hysterectomy (womb removed)	1.1	1.3	2.8	-0.7	0.8	1.7
Systolic blood pressure, automated reading	0.0	0.0	0.0	0.1	0.1	0.2
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	2.5	0.4	1.5	1.6
Angina	2.7	3.5	9.1	0.4	3.0	-1.1
Medication for hormone replacement therapy	1.0	1.1	2.2	1.5	0.8	0.6
Vitamin and mineral supplements	1.1	1.5	2.8	1.7	1.0	0.9
Supplements: Zinc	0.1	0.1	0.2	-0.4	-0.5	-0.2
Medication: Co-codamol	0.8	1.0	1.8	-0.3	-1.0	-1.4
Medication: Metformin	2.5	3.5	7.3	1.7	2.7	-0.4
Diabetes (father)	0.3	0.4	0.7	-0.5	0.9	0.5
Diabetes (mother)	2.0	2.5	2.7	1.6	1.6	-1.5
Severe depression (siblings)	1.5	1.7	2.9	1.7	-0.4	-1.4
Pack years adult smoking proportion	0.0	0.1	0.1	0.1	0.3	0.3
Impedance of leg (right)	0.5	2.5	6.6	-2.6	-0.5	0.8
Leg fat-free mass (left)	0.3	1.6	4.5	2.1	0.4	-0.3
Trunk fat percentage	0.1	0.6	1.6	-0.4	-1.2	0.2
Hand grip strength (right)	0.4	1.2	2.4	0.4	1.5	1.0
Townsend deprivation index at recruitment	0.7	1.0	1.8	0.4	-1.1	-1.3
Current tobacco smoking	0.6	1.0	1.5	-0.9	0.8	-1.2
Average weekly fortified wine intake	0.1	0.2	0.3	0.5	-0.4	-0.1
Maternal smoking around birth	1.2	1.8	4.0	-0.0	-1.2	-2.0
Fed-up feelings	0.3	0.6	1.2	-1.1	0.4	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.7	-0.5	-0.8	-1.3
Relative age voice broke	1.0	1.5	2.8	1.7	-0.1	-1.3
Taking other prescription medications	1.7	2.5	6.5	1.0	2.5	-0.2
Age when periods started (menarche)	0.6	1.4	3.2	1.8	0.2	1.0
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	3.0	-1.5	-0.2	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	-0.3	0.5	0.1
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.4	1.8	1.3	0.6
Qualifications: CSEs or equivalent	0.3	0.5	1.0	-0.4	-1.0	-0.4
Serious illness, injury or assault to yourself	0.7	0.9	1.1	-1.0	-0.8	0.9
High blood pressure	0.0	0.1	0.2	0.4	0.1	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.2	0.4	0.7
Multivitamins +/- minerals	0.5	0.6	0.7	-0.8	-0.7	-0.7
Stomach or abdominal pain in last month	0.6	0.7	1.5	0.2	-1.2	-0.7
Supplements: Glucosamine	0.0	0.1	0.1	0.2	0.0	0.4
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.1	0.2	0.0	-2.0
Medication: Atenolol	2.4	3.0	4.1	-1.2	2.0	1.9
Medication: Levothyroxine sodium	1.1	1.8	3.0	1.5	1.7	-0.5
Sitting height	0.4	2.9	8.2	2.9	-0.1	-0.8
Chronic bronchitis/emphysema (father)	2.5	2.9	4.5	-2.1	-0.1	-2.0
High blood pressure (mother)	0.3	0.4	0.6	-0.8	-0.7	0.4
Body mass index (BMI)	0.1	0.4	0.8	0.6	-0.9	-0.2
Impedance of leg (left)	0.4	1.9	4.8	-2.2	-0.5	0.8
Leg predicted mass (left)	0.3	1.7	4.7	2.2	0.5	-0.3
Trunk fat mass	0.1	0.3	0.5	0.5	-0.7	0.1
Waist circumference	0.2	0.6	1.3	1.1	0.6	0.3
Number of incorrect matches in round	0.1	0.2	0.4	0.2	-0.6	-0.4
Past tobacco smoking	0.6	1.1	2.3	-0.2	1.5	0.9
Alcohol usually taken with meals	2.5	4.0	10.5	3.2	0.7	1.0
Nervous feelings	0.9	1.7	4.8	-2.2	0.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.9	-1.4	-0.7	-0.3
Hearing difficulty/problems with background noise	0.5	0.8	1.6	0.5	-0.7	1.3
Hair/balding pattern: Pattern 2	2.2	2.8	5.1	-2.2	-1.0	-1.5
Had menopause	0.6	0.8	1.4	1.2	0.5	-0.8
Had other major operations	1.0	1.2	2.2	0.0	-1.2	-1.5
Forced vital capacity (FVC)	0.2	0.9	1.7	-1.3	-0.8	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	-0.5	0.2	0.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	-0.2	0.6	-0.3
Qualifications: None of the above	0.3	0.6	1.3	-1.1	0.2	0.7
Financial difficulties in last 2 years	0.4	0.5	1.1	1.0	-0.1	-0.7
Mouth/teeth dental problems	1.4	2.1	4.2	2.1	0.9	1.2
Heart attack	2.2	2.8	5.2	-0.1	1.8	2.3
Allergy	0.1	0.2	0.4	-0.3	0.0	0.6
Pain all over the body in last month	1.6	1.7	4.6	-2.1	-0.2	0.6
Diabetes (self-reported)	1.4	2.2	5.5	1.0	2.3	-0.2
Hayfever/allergic rhinitis (self-reported)	2.7	3.6	6.5	-1.5	1.4	2.5
Medication: Ramipril	1.1	1.4	1.6	1.0	1.3	1.3
Medication: Simvastatin	1.4	2.1	3.0	1.6	1.7	-0.9
Fluid intelligence score	0.7	1.4	3.9	-0.6	0.2	2.0
Illnesses of siblings	0.2	0.3	0.5	0.4	-0.3	0.7
Neuroticism score	1.3	2.6	5.1	-2.3	-0.1	1.6
Weight	0.1	0.7	2.0	1.4	-0.2	-0.2
Impedance of arm (right)	0.7	3.3	7.1	-2.7	-1.2	-1.1
Arm fat percentage (right)	0.2	0.8	1.8	-0.4	-1.4	-0.7
Trunk fat-free mass	0.5	2.7	7.0	2.6	1.1	0.2
Hip circumference	0.5	2.0	3.1	0.7	-1.5	-1.8
Time employed in main current job	1.3	1.5	4.4	0.4	-0.0	-2.1
Alcohol intake versus 10 years previously	1.0	1.5	4.0	-2.0	-0.5	-0.7
Father’s age at death	1.0	1.4	3.1	1.8	-0.5	-0.9
Worrier / anxious feelings	1.9	3.6	6.0	-2.4	0.9	2.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	-0.8	-0.1	-0.2
Falls in the last year	1.9	2.5	4.9	0.3	-2.2	-1.6
Hair/balding pattern: Pattern 3	1.7	2.5	5.9	0.8	1.1	2.4
Number of live births	1.9	2.6	6.8	-2.6	-0.4	-1.0
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	-0.0	-0.4	0.2
Pulse rate	0.2	0.3	0.6	0.5	0.1	0.8
Happiness	1.0	1.2	3.2	1.8	0.4	0.6
Noisy workplace	0.3	0.4	0.9	-0.4	0.9	0.3
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.1	1.8	0.1	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.1	-1.5	-0.8	0.4
Mouth/teeth dental problems: Dentures	0.8	1.3	2.4	-1.2	-1.6	0.0
Asthma	0.3	0.5	1.2	0.0	0.7	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.5	2.0	2.7	-0.9	-1.7	-1.5
Medication: Cholesterol lowering	0.5	0.7	1.6	1.2	0.8	-0.1
Depression (self-reported)	0.4	0.5	1.2	1.1	0.3	-0.6
Medication: Lansoprazole	1.1	1.2	1.6	-1.2	0.9	-1.1
Prospective memory result	0.3	0.4	0.6	0.2	0.7	-0.8
Lung cancer (father)	2.3	2.7	7.8	-2.8	-0.6	-0.2
Illnesses of mother	0.7	0.9	2.1	-0.5	-1.5	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.7	0.4	-0.8	0.6
Pulse wave Arterial Stiffness index	0.8	0.9	2.3	0.4	0.4	1.5
Impedance of arm (left)	0.6	2.7	5.1	-2.3	-1.5	-0.8
Arm fat mass (right)	0.1	0.4	0.6	0.7	-0.7	-0.4
Trunk predicted mass	0.5	2.9	7.4	2.7	1.1	0.2
Standing height	0.1	1.2	2.4	1.6	1.1	-0.2
Length of working week for main job	1.1	1.2	2.6	-0.7	-1.6	0.7
Exposure to tobacco smoke at home	1.3	1.5	2.2	-1.4	-1.5	-0.4
Breastfed as a baby	0.9	1.1	2.4	0.9	-1.6	-0.3
Tense / ‘highly strung’	1.0	1.6	4.6	-2.1	-0.1	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	3.7	-1.9	-0.8	-0.7
Hair/balding pattern: Pattern 4	0.4	0.9	2.1	0.8	0.3	1.4
Birth weight of first child	1.8	3.2	6.0	2.4	0.7	1.8
Peak expiratory flow (PEF)	0.2	0.5	1.5	1.2	0.2	-0.1
Pulse wave reflection index	0.6	0.7	2.1	-0.1	0.3	1.4
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.5	-1.0	1.2	0.5
Loud music exposure frequency	2.9	3.2	4.8	-0.3	-2.2	-2.2
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.5	2.1	0.6	-0.5
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	3.5	0.4	-0.2	-1.9
Blood clot in the leg (DVT)	0.2	0.2	0.5	-0.3	-0.3	-0.7
Medication: Paracetamol	0.7	1.2	3.0	-1.7	-0.7	0.3
Headache pain in last month	0.2	0.4	0.9	0.4	-0.1	-0.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.7	-0.8	-0.7	0.1
Glaucoma (self-reported)	0.8	0.9	1.7	-1.3	-0.9	-0.7
Gout (self-reported)	0.1	0.1	0.3	-0.0	0.5	-0.0
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	2.8	1.4	1.7	-0.5
Medication: Amlodipine	0.2	0.2	0.6	-0.3	0.8	0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.9	-1.4	0.7	-0.2
Birth weight	0.2	0.4	0.6	0.5	0.8	0.6
Chronic bronchitis/emphysema (mother)	3.4	4.0	8.2	-2.9	-1.9	-0.5
High blood pressure (siblings)	0.3	0.5	0.7	0.8	0.8	-0.4
Forced vital capacity (FVC), Best measure	0.2	0.6	0.7	-0.8	-0.8	0.6
Body fat percentage	0.2	0.6	1.7	-0.5	-1.3	-0.0
Leg fat percentage (right)	0.2	0.6	0.6	-0.8	-0.7	0.7
Arm fat-free mass (right)	0.8	4.2	11.2	3.3	1.0	0.7
Exposure to tobacco smoke outside home	0.2	0.3	0.8	0.0	0.0	-0.9
Comparative body size at age 10	0.3	0.8	1.9	1.4	-0.6	-0.2
Number of full brothers	1.5	1.9	3.6	-1.9	-1.4	0.6
Worry too long after embarrassment	0.9	1.6	3.6	-1.0	-1.9	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.9	-0.8	-2.0	-0.6
Wheeze or whistling in the chest in last year	1.6	2.9	8.3	-2.9	-0.1	0.7
Number of children fathered	0.8	1.0	1.7	-1.1	-1.3	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.3	0.0	0.2	1.1
Age at first live birth	1.0	1.7	4.8	2.2	-0.4	0.5
Pulse wave peak to peak time	0.7	0.9	2.3	-0.4	-0.5	-1.5
Health satisfaction	0.8	1.1	2.0	0.9	-0.6	-1.4
Shortness of breath walking on level ground	0.5	0.5	1.3	-0.4	-0.4	-1.2
Qualifications: College or University degree	1.1	3.5	6.6	2.6	2.0	0.4
Eye problems/disorders: None of the above	1.9	2.1	3.2	-1.8	-1.8	0.4
Mouth/teeth dental problems: Loose teeth	1.2	1.5	4.0	-2.0	-0.5	0.2
Emphysema/chronic bronchitis	2.3	2.6	7.2	0.5	0.6	-2.7
Medication for pain relief, constipation, heartburn	0.6	1.0	2.3	0.5	1.5	0.7
Neck or shoulder pain in last month	1.4	2.1	3.8	0.6	-1.9	-1.4
Medication: Blood pressure	0.3	0.6	1.1	0.8	1.0	0.3
Angina (self-reported)	2.5	3.3	9.1	0.3	3.0	-0.9
Migraine (self-reported)	0.7	0.8	1.9	-0.0	0.8	-1.4
Medication: Ibuprofen	1.3	1.5	2.5	-0.9	-1.1	-1.6
Medication: Allopurinol	0.5	0.7	2.0	-0.2	1.4	0.2
Medication: Omeprazole	0.1	0.2	0.3	-0.4	-0.2	0.6
Medication: Seretide 50 evohaler	0.4	0.5	0.6	-0.8	-0.8	-0.5
Mean time to correctly identify matches	1.7	3.3	3.9	-1.5	2.0	1.9
Heart disease (mother)	3.3	4.0	5.0	1.6	2.2	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.0	-1.2	-0.4	1.7
Whole body fat mass	0.1	0.3	0.4	0.7	-0.7	-0.2
Leg fat mass (right)	0.1	0.2	0.3	0.5	-0.6	0.2
Arm predicted mass (right)	0.7	3.8	10.0	3.2	0.9	0.7
Pulse rate, automated reading	0.6	2.0	3.5	-0.1	1.6	1.9
Alcohol intake frequency.	0.4	0.8	1.4	-1.2	-0.9	0.6
Comparative height size at age 10	0.1	0.5	0.9	0.2	0.9	0.8
Number of full sisters	1.1	1.3	2.1	-1.4	0.5	-1.3
Suffer from ‘nerves’	1.0	1.6	4.0	-2.0	-0.1	0.9
Overall health rating	0.0	0.0	0.0	-0.0	-0.2	-0.1
Chest pain or discomfort	0.7	1.1	1.7	-1.3	-0.1	-1.2
Had major operations	0.3	0.4	0.8	-0.3	-0.9	-0.5
Age at last live birth	0.4	0.6	1.5	1.2	-0.1	-0.4
Family relationship satisfaction	0.8	1.0	2.4	1.5	-0.3	-0.6
Leg pain on walking	2.2	2.7	3.5	-1.8	-1.9	-1.2
Qualifications: NVQ or HND or HNC or equivalent	4.5	5.4	8.4	-1.9	-2.9	-2.1
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.9	-0.8	-2.0	-0.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	0.6	1.0	-0.3
Medication: Aspirin	0.1	0.2	0.3	0.5	-0.2	0.5
Supplements: Vitamin C	0.4	0.5	0.7	-0.7	-0.8	-0.5
Knee pain experienced in last month	0.6	1.0	1.4	1.2	-1.1	-0.5
Hypertension (Self-reported)	0.1	0.3	0.6	0.8	0.3	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.0	0.6	1.7	-0.4
Illnesses of father: Heart disease	0.3	0.4	0.5	-0.7	0.7	0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.3	0.4	0.5	-0.6
Smoking status: Previous	0.6	0.9	1.7	0.7	-1.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.2	0.2	-1.5	-0.7
Whole body fat-free mass	0.5	2.6	7.3	2.7	0.8	-0.0
Leg fat-free mass (right)	0.4	2.1	6.2	2.5	0.5	-0.2
Arm fat percentage (left)	0.2	0.6	1.7	-0.1	-1.3	-0.4
Average weekly red wine intake	1.7	2.5	7.5	2.7	-0.2	-0.2
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.0	-0.4	1.7	-0.8
Mood swings	0.7	1.2	1.5	-1.2	-1.2	-0.9
Loneliness, isolation	1.0	1.4	3.1	-0.7	-0.6	-1.8
Long-standing illness, disability or infirmity	0.3	0.4	0.6	0.4	-0.7	-0.8
Ever had bowel cancer screening	1.7	2.0	3.1	-1.8	-0.2	-1.7
Diabetes diagnosed by doctor	2.8	4.6	9.0	3.0	2.1	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.1	0.0	-1.5	1.3
Friendships satisfaction	1.2	1.5	1.8	1.1	-1.3	-1.3
Qualifications: nursing, teaching	0.1	0.2	0.6	0.1	-0.7	0.2
Commuting to job workplace: Walk	0.2	0.3	0.4	0.6	0.6	-0.2
Eye problems/disorders: Cataract	2.0	2.3	6.6	2.6	0.3	0.3
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	3.6	-1.9	-0.9	-1.8
Medication for cholesterol	0.3	0.4	0.9	-0.9	-0.6	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.7	-0.1	0.1	0.8
Back pain experienced in last month	0.8	1.1	1.9	1.1	-1.4	0.4
Mineral and other dietary supplements	1.0	1.3	3.6	1.9	-0.6	-0.4
Breast cancer (self-reported)	0.0	0.1	0.2	-0.4	0.0	-0.0
Asthma (self-reported)	0.2	0.5	1.0	0.2	1.0	-0.6
Osteoporosis (self-reported)	1.0	1.3	2.4	-0.0	1.2	1.5
Osteoarthritis (self-reported)	0.2	0.3	0.3	-0.4	0.6	0.5
Medication: Aspirin	0.3	0.4	0.5	0.6	0.5	0.7
Medication: Gliclazide	3.7	4.2	5.6	2.0	2.4	1.8
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	1.1	0.0	0.1
Smoking status: Current	0.7	1.1	2.1	-0.8	0.8	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.3	0.3	1.2	-0.3
Whole body water mass	0.5	3.0	8.3	2.9	0.8	0.0
Leg predicted mass (right)	0.4	2.3	6.4	2.5	0.5	-0.3
Arm fat mass (left)	0.1	0.6	1.0	1.0	-0.8	-0.2
Number of self-reported non-cancer illnesses	0.5	0.9	2.6	-0.0	1.6	-0.4
Average weekly champagne plus white wine intake	0.3	0.4	0.8	0.6	-0.9	-0.3
Miserableness	1.6	2.8	7.2	-2.7	-0.3	1.1
Guilty feelings	2.9	4.4	8.5	-1.4	-1.6	-2.9
Wears glasses or contact lenses	0.4	0.4	0.9	-0.3	-0.9	-0.6
Ever taken oral contraceptive pill	0.8	0.9	2.6	-0.0	-0.4	-1.6
Hearing aid user	0.6	0.6	0.7	0.8	0.8	0.8
Mother’s age at death	1.4	1.7	4.3	-0.8	2.1	0.5
Financial situation satisfaction	1.3	1.6	4.6	2.2	0.0	-0.4
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.8	-0.4	-0.1	0.9
Commuting to job workplace: Public transport	0.8	0.9	1.2	1.1	0.8	0.9
Eye problems/disorders: Glaucoma	0.1	0.2	0.5	-0.7	-0.1	0.1
Medication: Blood pressure	0.9	1.7	1.8	1.3	1.3	1.3
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.6	-1.9	0.5	-0.0
Supplements: Fish oil (including cod liver oil)	2.0	2.6	6.8	-2.6	0.8	0.6
High cholesterol (Self-reported)	1.3	2.3	5.4	0.3	2.3	-1.1
Medication: Bendroflumethiazide	0.5	0.8	2.1	-0.4	0.4	1.4
Medication: Paracetamol	0.7	1.1	2.2	-1.5	0.0	1.0
Medication: Lisinopril	0.2	0.3	0.8	-0.2	0.9	-0.0
Medication: Atorvastatin	0.2	0.2	0.5	0.3	-0.3	-0.7
Illnesses of father: High blood pressure	0.3	0.3	0.9	-0.3	-0.9	0.2
Alcohol drinker status: Never	0.8	1.0	1.5	0.1	-1.2	-1.1
Ever smoked	0.7	1.3	3.0	-0.4	-1.7	-0.9
Basal metabolic rate	0.3	1.9	5.5	2.3	0.5	-0.0
Leg fat percentage (left)	0.1	0.5	0.7	-0.6	-0.7	0.8
Arm fat-free mass (left)	0.6	3.1	8.6	2.9	0.6	0.4
Number of operations (self-reported)	1.2	1.8	3.2	-0.1	-1.5	-1.8
Average weekly beer plus cider intake	1.3	1.8	3.2	-1.5	-1.8	-0.2
Irritability	0.9	1.6	2.7	-1.6	-1.2	0.7
Risk taking	0.4	0.6	1.4	1.2	-0.5	0.2
Ever had prostate specific antigen (PSA) test	1.9	2.2	4.5	0.6	-1.3	-2.1
Fractured/broken bones in last 5 years	0.3	0.3	0.5	0.2	-0.7	-0.7
Age started oral contraceptive pill	0.2	0.2	0.6	0.1	0.1	-0.8
Diastolic blood pressure, automated reading	0.2	0.5	1.1	1.0	0.5	0.4
Ever depressed for a whole week	0.4	0.5	0.7	-0.8	-0.6	-0.6
Unable to work because of sickness or disability	0.6	0.8	1.8	0.7	-0.1	-1.3
Commuting to job workplace: Cycle	1.5	1.8	4.1	2.0	-0.6	1.0
Myopia	1.3	1.9	3.7	0.5	1.9	1.3
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.6	-0.4	-0.8	-0.6
Cholesterol lowering medication	1.5	2.3	3.9	0.3	2.0	-1.7
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.4	-0.2	0.3
Pain experienced in last month	0.5	0.9	1.5	1.0	1.2	-0.3
Supplements: Calcium	1.3	1.4	3.2	-1.8	-1.0	0.4
Basal cell carcinoma (self-reported)	2.6	3.1	5.7	1.9	2.4	-0.2
Heart attack/myocardial infarction (self-reported)	2.1	2.7	4.7	0.0	1.8	2.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	-0.3	-0.4	-0.7
Heart disease (siblings)	1.7	2.0	5.1	-2.3	1.0	-0.2
Alcohol drinker status: Previous	1.1	1.3	2.5	1.6	-0.9	0.8
Pack years of smoking	0.0	0.0	0.1	-0.2	0.2	-0.0
Impedance of whole body	0.5	2.8	6.5	-2.5	-1.4	-0.1
Leg fat mass (left)	0.1	0.3	0.5	0.7	-0.5	0.2
Arm predicted mass (left)	0.6	3.1	8.6	2.9	0.7	0.4