Hub : Genes

GPR116

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cortex 0.3120 0.1110 0.00670 0.004 NA -0.007 NA 0.002 2.4e-01 NA 5.6e-01 NA 2.7e-01
2 TCGA Breast Invasive Carcinoma 0.0391 0.0157 0.00031 0.030 0.023 0.018 NA 0.022 6.8e-07 1.1e-05 9.4e-05 NA 1.8e-05
3 TCGA Brain Lower Grade Glioma 0.0700 0.0347 0.00830 0.010 0.012 0.006 NA 0.005 2.1e-02 1.5e-02 5.7e-02 NA 7.9e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.7 1.2 2.4 -0.2 1.0 1.5
Bipolar Disorder or Schizophrenia 0.4 0.9 2.1 -0.1 -0.8 -1.5
Depressed Affect (Nagel 2018) 0.1 0.3 0.8 -0.9 -0.1 -0.0
Depression (Nagel 2018) 0.6 0.9 1.7 -0.7 -0.9 -1.3
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.5 -0.2 -0.4 0.7
Neuroticism (Nagel 2018) 0.9 2.1 5.5 -2.3 -0.4 0.8
Schizophrenia (2018) 2.1 4.3 9.6 0.0 -1.8 -3.1
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 -0.4 -0.1 -0.2
Worry (Nagel 2018) 1.5 3.2 5.6 -2.4 1.1 1.7
Alzheimer’s Disease (in mother) 0.6 0.7 1.4 1.2 0.5 0.6
Alzheimer’s Disease (in father) 0.9 1.0 2.9 -0.2 0.3 1.7
Alzheimer’s Disease (including proxy) 0.9 1.3 3.7 0.5 -0.2 1.9
Crohns Disease (2017) 0.3 0.7 1.1 -0.4 -1.0 1.1
Irritable Bowel Disease (IBD) 0.6 1.4 3.4 0.3 -0.8 1.8
Ulcerative Colitis (UC) 0.6 1.1 2.8 0.1 -0.6 1.7
Major Depression (MDD) 0.4 0.5 0.8 -0.8 0.9 -0.1
Reaction Time 2.1 4.0 6.9 -1.5 1.8 2.6
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.4 -1.0 -0.0 1.2
Breast Cancer 1.3 3.2 5.1 0.3 2.1 2.3
Ovarian Cancer 0.3 0.4 1.0 -1.0 0.3 0.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.5 0.7 1.0 1.0 -1.0 -0.4
Bipolar Disorder (2011) 0.7 0.7 1.1 1.0 0.1 -1.0
Body Mass Index (BMI) (2010) 1.5 2.0 3.6 0.9 -1.3 -1.9
Coronary Artery Disease (CAD) 0.2 0.2 0.3 0.6 0.5 0.2
Crohns Disease (2012) 0.3 0.5 1.3 -0.5 -0.1 1.2
Mean Putamen Volume 2.5 2.8 4.3 -1.6 1.2 2.1
Fasting Glucose 0.7 0.8 1.0 0.8 -0.9 -1.0
HbA1C 2.7 3.0 6.5 2.5 0.1 1.5
HDL Cholesterol 0.3 0.5 0.7 -0.6 -0.8 -0.6
LDL Cholesterol 0.3 0.5 1.4 0.3 -0.1 -1.2
Lupus 0.3 0.5 1.2 0.3 -0.5 1.1
Neuroticism (2016) 3.1 4.4 9.2 -3.0 -1.8 1.0
Primary Biliary Cirrhosis 0.5 0.7 1.5 -0.6 1.2 0.1
Rheumatoid Arthritis 1.4 2.0 4.9 0.9 -2.2 -0.4
Schizophrenia (2014) 0.7 1.6 3.5 -0.9 -0.7 -1.9
Triglycerides 0.5 0.8 1.1 1.1 0.9 -0.6
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.5 -0.5 0.3 -0.7
Ulcerative Colitis 0.7 0.9 2.4 0.6 -0.3 1.6
Blood Eosinophil Count 0.5 3.5 6.9 1.4 1.3 2.6
Blood Platelet Count 0.5 6.0 7.0 -2.5 -2.2 -2.6
Blood Red Count 0.1 0.5 0.9 0.9 0.1 0.8
Blood White Count 1.4 10.4 30.3 -0.5 -0.8 5.5
Heel T-Score 0.0 0.2 0.3 0.5 -0.1 0.4
BMI 0.5 2.7 7.0 2.6 -1.1 0.1
Height 0.1 2.0 3.4 0.2 1.9 1.6
Waist Hip Ratio (WHR) 1.6 7.1 11.6 1.6 2.7 3.4
Systolic Blood Pressure 0.3 1.5 3.8 -2.0 -0.5 0.6
Smoking Status 0.0 0.1 0.2 -0.3 0.2 -0.4
Allergy or Eczema 0.1 0.2 0.4 0.2 0.1 0.7
Cardiovascular Disease 0.1 0.2 0.2 0.4 0.4 -0.4
Hypothyroidism (self reported) 0.6 1.3 2.0 1.4 1.1 -0.9
Respiratory disease 0.5 1.0 1.8 -0.5 1.0 -1.3
Type 2 Diabetes (T2D) (2018) 1.5 2.8 6.8 2.6 1.3 -0.3
Lung FEV1/FVC ratio 1.3 6.7 19.1 4.4 0.8 -0.6
Lung FVC 0.1 0.5 1.2 -1.1 -0.5 0.1
Neuroticism 0.5 1.2 2.0 -1.4 0.4 1.1
Chronotype (morning person) 0.5 1.2 2.7 1.6 0.1 -1.0
Hair Pigment 0.0 0.4 0.9 -0.3 -0.9 -0.3
Tanning 0.2 1.8 2.7 -1.5 -0.8 -1.6
Hand grip strength (left) 0.2 0.6 1.0 -0.8 1.0 0.3
Number of treatments/medications taken 0.3 0.6 1.8 -0.2 1.3 -0.2
Average weekly spirits intake 0.3 0.4 0.8 -0.7 -0.9 0.0
Sensitivity / hurt feelings 0.5 0.8 1.8 -1.4 -0.7 0.1
Frequency of depressed mood in last 2 weeks 0.9 1.3 2.0 -1.3 -1.4 -0.4
Hearing difficulty/problems: Yes 1.0 1.5 3.6 -0.6 -1.9 0.7
Relative age of first facial hair 0.4 0.9 1.6 0.2 1.3 -1.0
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.8 0.7 1.3 -0.2
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.6 -0.5 0.5 -1.6
Ever had hysterectomy (womb removed) 1.1 1.3 2.8 -0.7 0.8 1.7
Systolic blood pressure, automated reading 0.0 0.0 0.0 0.1 0.1 0.2
Eye problems/disorders: Diabetes related eye disease 1.5 1.6 2.5 0.4 1.5 1.6
Angina 2.7 3.5 9.1 0.4 3.0 -1.1
Medication for hormone replacement therapy 1.0 1.1 2.2 1.5 0.8 0.6
Vitamin and mineral supplements 1.1 1.5 2.8 1.7 1.0 0.9
Supplements: Zinc 0.1 0.1 0.2 -0.4 -0.5 -0.2
Medication: Co-codamol 0.8 1.0 1.8 -0.3 -1.0 -1.4
Medication: Metformin 2.5 3.5 7.3 1.7 2.7 -0.4
Diabetes (father) 0.3 0.4 0.7 -0.5 0.9 0.5
Diabetes (mother) 2.0 2.5 2.7 1.6 1.6 -1.5
Severe depression (siblings) 1.5 1.7 2.9 1.7 -0.4 -1.4
Pack years adult smoking proportion 0.0 0.1 0.1 0.1 0.3 0.3
Impedance of leg (right) 0.5 2.5 6.6 -2.6 -0.5 0.8
Leg fat-free mass (left) 0.3 1.6 4.5 2.1 0.4 -0.3
Trunk fat percentage 0.1 0.6 1.6 -0.4 -1.2 0.2
Hand grip strength (right) 0.4 1.2 2.4 0.4 1.5 1.0
Townsend deprivation index at recruitment 0.7 1.0 1.8 0.4 -1.1 -1.3
Current tobacco smoking 0.6 1.0 1.5 -0.9 0.8 -1.2
Average weekly fortified wine intake 0.1 0.2 0.3 0.5 -0.4 -0.1
Maternal smoking around birth 1.2 1.8 4.0 -0.0 -1.2 -2.0
Fed-up feelings 0.3 0.6 1.2 -1.1 0.4 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.7 -0.5 -0.8 -1.3
Relative age voice broke 1.0 1.5 2.8 1.7 -0.1 -1.3
Taking other prescription medications 1.7 2.5 6.5 1.0 2.5 -0.2
Age when periods started (menarche) 0.6 1.4 3.2 1.8 0.2 1.0
Bilateral oophorectomy (both ovaries removed) 1.5 1.8 3.0 -1.5 -0.2 1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.1 0.2 -0.3 0.5 0.1
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 3.4 1.8 1.3 0.6
Qualifications: CSEs or equivalent 0.3 0.5 1.0 -0.4 -1.0 -0.4
Serious illness, injury or assault to yourself 0.7 0.9 1.1 -1.0 -0.8 0.9
High blood pressure 0.0 0.1 0.2 0.4 0.1 0.3
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.5 0.2 0.4 0.7
Multivitamins +/- minerals 0.5 0.6 0.7 -0.8 -0.7 -0.7
Stomach or abdominal pain in last month 0.6 0.7 1.5 0.2 -1.2 -0.7
Supplements: Glucosamine 0.0 0.1 0.1 0.2 0.0 0.4
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 4.1 0.2 0.0 -2.0
Medication: Atenolol 2.4 3.0 4.1 -1.2 2.0 1.9
Medication: Levothyroxine sodium 1.1 1.8 3.0 1.5 1.7 -0.5
Sitting height 0.4 2.9 8.2 2.9 -0.1 -0.8
Chronic bronchitis/emphysema (father) 2.5 2.9 4.5 -2.1 -0.1 -2.0
High blood pressure (mother) 0.3 0.4 0.6 -0.8 -0.7 0.4
Body mass index (BMI) 0.1 0.4 0.8 0.6 -0.9 -0.2
Impedance of leg (left) 0.4 1.9 4.8 -2.2 -0.5 0.8
Leg predicted mass (left) 0.3 1.7 4.7 2.2 0.5 -0.3
Trunk fat mass 0.1 0.3 0.5 0.5 -0.7 0.1
Waist circumference 0.2 0.6 1.3 1.1 0.6 0.3
Number of incorrect matches in round 0.1 0.2 0.4 0.2 -0.6 -0.4
Past tobacco smoking 0.6 1.1 2.3 -0.2 1.5 0.9
Alcohol usually taken with meals 2.5 4.0 10.5 3.2 0.7 1.0
Nervous feelings 0.9 1.7 4.8 -2.2 0.4 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.9 -1.4 -0.7 -0.3
Hearing difficulty/problems with background noise 0.5 0.8 1.6 0.5 -0.7 1.3
Hair/balding pattern: Pattern 2 2.2 2.8 5.1 -2.2 -1.0 -1.5
Had menopause 0.6 0.8 1.4 1.2 0.5 -0.8
Had other major operations 1.0 1.2 2.2 0.0 -1.2 -1.5
Forced vital capacity (FVC) 0.2 0.9 1.7 -1.3 -0.8 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.2 -0.5 0.2 0.0
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.4 -0.2 0.6 -0.3
Qualifications: None of the above 0.3 0.6 1.3 -1.1 0.2 0.7
Financial difficulties in last 2 years 0.4 0.5 1.1 1.0 -0.1 -0.7
Mouth/teeth dental problems 1.4 2.1 4.2 2.1 0.9 1.2
Heart attack 2.2 2.8 5.2 -0.1 1.8 2.3
Allergy 0.1 0.2 0.4 -0.3 0.0 0.6
Pain all over the body in last month 1.6 1.7 4.6 -2.1 -0.2 0.6
Diabetes (self-reported) 1.4 2.2 5.5 1.0 2.3 -0.2
Hayfever/allergic rhinitis (self-reported) 2.7 3.6 6.5 -1.5 1.4 2.5
Medication: Ramipril 1.1 1.4 1.6 1.0 1.3 1.3
Medication: Simvastatin 1.4 2.1 3.0 1.6 1.7 -0.9
Fluid intelligence score 0.7 1.4 3.9 -0.6 0.2 2.0
Illnesses of siblings 0.2 0.3 0.5 0.4 -0.3 0.7
Neuroticism score 1.3 2.6 5.1 -2.3 -0.1 1.6
Weight 0.1 0.7 2.0 1.4 -0.2 -0.2
Impedance of arm (right) 0.7 3.3 7.1 -2.7 -1.2 -1.1
Arm fat percentage (right) 0.2 0.8 1.8 -0.4 -1.4 -0.7
Trunk fat-free mass 0.5 2.7 7.0 2.6 1.1 0.2
Hip circumference 0.5 2.0 3.1 0.7 -1.5 -1.8
Time employed in main current job 1.3 1.5 4.4 0.4 -0.0 -2.1
Alcohol intake versus 10 years previously 1.0 1.5 4.0 -2.0 -0.5 -0.7
Father’s age at death 1.0 1.4 3.1 1.8 -0.5 -0.9
Worrier / anxious feelings 1.9 3.6 6.0 -2.4 0.9 2.0
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.6 -0.8 -0.1 -0.2
Falls in the last year 1.9 2.5 4.9 0.3 -2.2 -1.6
Hair/balding pattern: Pattern 3 1.7 2.5 5.9 0.8 1.1 2.4
Number of live births 1.9 2.6 6.8 -2.6 -0.4 -1.0
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.2 -0.0 -0.4 0.2
Pulse rate 0.2 0.3 0.6 0.5 0.1 0.8
Happiness 1.0 1.2 3.2 1.8 0.4 0.6
Noisy workplace 0.3 0.4 0.9 -0.4 0.9 0.3
Qualifications: A levels/AS levels or equivalent 0.6 1.3 3.1 1.8 0.1 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.8 1.0 2.1 -1.5 -0.8 0.4
Mouth/teeth dental problems: Dentures 0.8 1.3 2.4 -1.2 -1.6 0.0
Asthma 0.3 0.5 1.2 0.0 0.7 -1.1
Medication: Ibuprofen (e.g. Nurofen) 1.5 2.0 2.7 -0.9 -1.7 -1.5
Medication: Cholesterol lowering 0.5 0.7 1.6 1.2 0.8 -0.1
Depression (self-reported) 0.4 0.5 1.2 1.1 0.3 -0.6
Medication: Lansoprazole 1.1 1.2 1.6 -1.2 0.9 -1.1
Prospective memory result 0.3 0.4 0.6 0.2 0.7 -0.8
Lung cancer (father) 2.3 2.7 7.8 -2.8 -0.6 -0.2
Illnesses of mother 0.7 0.9 2.1 -0.5 -1.5 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.7 0.4 -0.8 0.6
Pulse wave Arterial Stiffness index 0.8 0.9 2.3 0.4 0.4 1.5
Impedance of arm (left) 0.6 2.7 5.1 -2.3 -1.5 -0.8
Arm fat mass (right) 0.1 0.4 0.6 0.7 -0.7 -0.4
Trunk predicted mass 0.5 2.9 7.4 2.7 1.1 0.2
Standing height 0.1 1.2 2.4 1.6 1.1 -0.2
Length of working week for main job 1.1 1.2 2.6 -0.7 -1.6 0.7
Exposure to tobacco smoke at home 1.3 1.5 2.2 -1.4 -1.5 -0.4
Breastfed as a baby 0.9 1.1 2.4 0.9 -1.6 -0.3
Tense / ‘highly strung’ 1.0 1.6 4.6 -2.1 -0.1 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 3.7 -1.9 -0.8 -0.7
Hair/balding pattern: Pattern 4 0.4 0.9 2.1 0.8 0.3 1.4
Birth weight of first child 1.8 3.2 6.0 2.4 0.7 1.8
Peak expiratory flow (PEF) 0.2 0.5 1.5 1.2 0.2 -0.1
Pulse wave reflection index 0.6 0.7 2.1 -0.1 0.3 1.4
Ever highly irritable/argumentative for 2 days 0.7 0.9 1.5 -1.0 1.2 0.5
Loud music exposure frequency 2.9 3.2 4.8 -0.3 -2.2 -2.2
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 4.5 2.1 0.6 -0.5
Mouth/teeth dental problems: Bleeding gums 1.0 1.2 3.5 0.4 -0.2 -1.9
Blood clot in the leg (DVT) 0.2 0.2 0.5 -0.3 -0.3 -0.7
Medication: Paracetamol 0.7 1.2 3.0 -1.7 -0.7 0.3
Headache pain in last month 0.2 0.4 0.9 0.4 -0.1 -0.9
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.7 -0.8 -0.7 0.1
Glaucoma (self-reported) 0.8 0.9 1.7 -1.3 -0.9 -0.7
Gout (self-reported) 0.1 0.1 0.3 -0.0 0.5 -0.0
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 2.8 1.4 1.7 -0.5
Medication: Amlodipine 0.2 0.2 0.6 -0.3 0.8 0.1
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.9 -1.4 0.7 -0.2
Birth weight 0.2 0.4 0.6 0.5 0.8 0.6
Chronic bronchitis/emphysema (mother) 3.4 4.0 8.2 -2.9 -1.9 -0.5
High blood pressure (siblings) 0.3 0.5 0.7 0.8 0.8 -0.4
Forced vital capacity (FVC), Best measure 0.2 0.6 0.7 -0.8 -0.8 0.6
Body fat percentage 0.2 0.6 1.7 -0.5 -1.3 -0.0
Leg fat percentage (right) 0.2 0.6 0.6 -0.8 -0.7 0.7
Arm fat-free mass (right) 0.8 4.2 11.2 3.3 1.0 0.7
Exposure to tobacco smoke outside home 0.2 0.3 0.8 0.0 0.0 -0.9
Comparative body size at age 10 0.3 0.8 1.9 1.4 -0.6 -0.2
Number of full brothers 1.5 1.9 3.6 -1.9 -1.4 0.6
Worry too long after embarrassment 0.9 1.6 3.6 -1.0 -1.9 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 3.9 -0.8 -2.0 -0.6
Wheeze or whistling in the chest in last year 1.6 2.9 8.3 -2.9 -0.1 0.7
Number of children fathered 0.8 1.0 1.7 -1.1 -1.3 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.3 0.0 0.2 1.1
Age at first live birth 1.0 1.7 4.8 2.2 -0.4 0.5
Pulse wave peak to peak time 0.7 0.9 2.3 -0.4 -0.5 -1.5
Health satisfaction 0.8 1.1 2.0 0.9 -0.6 -1.4
Shortness of breath walking on level ground 0.5 0.5 1.3 -0.4 -0.4 -1.2
Qualifications: College or University degree 1.1 3.5 6.6 2.6 2.0 0.4
Eye problems/disorders: None of the above 1.9 2.1 3.2 -1.8 -1.8 0.4
Mouth/teeth dental problems: Loose teeth 1.2 1.5 4.0 -2.0 -0.5 0.2
Emphysema/chronic bronchitis 2.3 2.6 7.2 0.5 0.6 -2.7
Medication for pain relief, constipation, heartburn 0.6 1.0 2.3 0.5 1.5 0.7
Neck or shoulder pain in last month 1.4 2.1 3.8 0.6 -1.9 -1.4
Medication: Blood pressure 0.3 0.6 1.1 0.8 1.0 0.3
Angina (self-reported) 2.5 3.3 9.1 0.3 3.0 -0.9
Migraine (self-reported) 0.7 0.8 1.9 -0.0 0.8 -1.4
Medication: Ibuprofen 1.3 1.5 2.5 -0.9 -1.1 -1.6
Medication: Allopurinol 0.5 0.7 2.0 -0.2 1.4 0.2
Medication: Omeprazole 0.1 0.2 0.3 -0.4 -0.2 0.6
Medication: Seretide 50 evohaler 0.4 0.5 0.6 -0.8 -0.8 -0.5
Mean time to correctly identify matches 1.7 3.3 3.9 -1.5 2.0 1.9
Heart disease (mother) 3.3 4.0 5.0 1.6 2.2 2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 3.0 -1.2 -0.4 1.7
Whole body fat mass 0.1 0.3 0.4 0.7 -0.7 -0.2
Leg fat mass (right) 0.1 0.2 0.3 0.5 -0.6 0.2
Arm predicted mass (right) 0.7 3.8 10.0 3.2 0.9 0.7
Pulse rate, automated reading 0.6 2.0 3.5 -0.1 1.6 1.9
Alcohol intake frequency. 0.4 0.8 1.4 -1.2 -0.9 0.6
Comparative height size at age 10 0.1 0.5 0.9 0.2 0.9 0.8
Number of full sisters 1.1 1.3 2.1 -1.4 0.5 -1.3
Suffer from ‘nerves’ 1.0 1.6 4.0 -2.0 -0.1 0.9
Overall health rating 0.0 0.0 0.0 -0.0 -0.2 -0.1
Chest pain or discomfort 0.7 1.1 1.7 -1.3 -0.1 -1.2
Had major operations 0.3 0.4 0.8 -0.3 -0.9 -0.5
Age at last live birth 0.4 0.6 1.5 1.2 -0.1 -0.4
Family relationship satisfaction 0.8 1.0 2.4 1.5 -0.3 -0.6
Leg pain on walking 2.2 2.7 3.5 -1.8 -1.9 -1.2
Qualifications: NVQ or HND or HNC or equivalent 4.5 5.4 8.4 -1.9 -2.9 -2.1
Commuting to job workplace: Car/motor vehicle 1.5 1.7 3.9 -0.8 -2.0 -0.8
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.0 0.6 1.0 -0.3
Medication: Aspirin 0.1 0.2 0.3 0.5 -0.2 0.5
Supplements: Vitamin C 0.4 0.5 0.7 -0.7 -0.8 -0.5
Knee pain experienced in last month 0.6 1.0 1.4 1.2 -1.1 -0.5
Hypertension (Self-reported) 0.1 0.3 0.6 0.8 0.3 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 3.0 0.6 1.7 -0.4
Illnesses of father: Heart disease 0.3 0.4 0.5 -0.7 0.7 0.1
Illnesses of siblings: Diabetes 0.2 0.2 0.3 0.4 0.5 -0.6
Smoking status: Previous 0.6 0.9 1.7 0.7 -1.3 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.2 0.2 -1.5 -0.7
Whole body fat-free mass 0.5 2.6 7.3 2.7 0.8 -0.0
Leg fat-free mass (right) 0.4 2.1 6.2 2.5 0.5 -0.2
Arm fat percentage (left) 0.2 0.6 1.7 -0.1 -1.3 -0.4
Average weekly red wine intake 1.7 2.5 7.5 2.7 -0.2 -0.2
Handedness (chirality/laterality): Left-handed 1.1 1.3 3.0 -0.4 1.7 -0.8
Mood swings 0.7 1.2 1.5 -1.2 -1.2 -0.9
Loneliness, isolation 1.0 1.4 3.1 -0.7 -0.6 -1.8
Long-standing illness, disability or infirmity 0.3 0.4 0.6 0.4 -0.7 -0.8
Ever had bowel cancer screening 1.7 2.0 3.1 -1.8 -0.2 -1.7
Diabetes diagnosed by doctor 2.8 4.6 9.0 3.0 2.1 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 2.1 0.0 -1.5 1.3
Friendships satisfaction 1.2 1.5 1.8 1.1 -1.3 -1.3
Qualifications: nursing, teaching 0.1 0.2 0.6 0.1 -0.7 0.2
Commuting to job workplace: Walk 0.2 0.3 0.4 0.6 0.6 -0.2
Eye problems/disorders: Cataract 2.0 2.3 6.6 2.6 0.3 0.3
Mouth/teeth dental problems: Mouth ulcers 1.6 2.6 3.6 -1.9 -0.9 -1.8
Medication for cholesterol 0.3 0.4 0.9 -0.9 -0.6 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.7 -0.1 0.1 0.8
Back pain experienced in last month 0.8 1.1 1.9 1.1 -1.4 0.4
Mineral and other dietary supplements 1.0 1.3 3.6 1.9 -0.6 -0.4
Breast cancer (self-reported) 0.0 0.1 0.2 -0.4 0.0 -0.0
Asthma (self-reported) 0.2 0.5 1.0 0.2 1.0 -0.6
Osteoporosis (self-reported) 1.0 1.3 2.4 -0.0 1.2 1.5
Osteoarthritis (self-reported) 0.2 0.3 0.3 -0.4 0.6 0.5
Medication: Aspirin 0.3 0.4 0.5 0.6 0.5 0.7
Medication: Gliclazide 3.7 4.2 5.6 2.0 2.4 1.8
Illnesses of father: None of the above (group 1) 0.3 0.4 1.3 1.1 0.0 0.1
Smoking status: Current 0.7 1.1 2.1 -0.8 0.8 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.3 0.3 1.2 -0.3
Whole body water mass 0.5 3.0 8.3 2.9 0.8 0.0
Leg predicted mass (right) 0.4 2.3 6.4 2.5 0.5 -0.3
Arm fat mass (left) 0.1 0.6 1.0 1.0 -0.8 -0.2
Number of self-reported non-cancer illnesses 0.5 0.9 2.6 -0.0 1.6 -0.4
Average weekly champagne plus white wine intake 0.3 0.4 0.8 0.6 -0.9 -0.3
Miserableness 1.6 2.8 7.2 -2.7 -0.3 1.1
Guilty feelings 2.9 4.4 8.5 -1.4 -1.6 -2.9
Wears glasses or contact lenses 0.4 0.4 0.9 -0.3 -0.9 -0.6
Ever taken oral contraceptive pill 0.8 0.9 2.6 -0.0 -0.4 -1.6
Hearing aid user 0.6 0.6 0.7 0.8 0.8 0.8
Mother’s age at death 1.4 1.7 4.3 -0.8 2.1 0.5
Financial situation satisfaction 1.3 1.6 4.6 2.2 0.0 -0.4
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.8 -0.4 -0.1 0.9
Commuting to job workplace: Public transport 0.8 0.9 1.2 1.1 0.8 0.9
Eye problems/disorders: Glaucoma 0.1 0.2 0.5 -0.7 -0.1 0.1
Medication: Blood pressure 0.9 1.7 1.8 1.3 1.3 1.3
Pain type(s) experienced in last month: Hip pain 1.0 1.3 3.6 -1.9 0.5 -0.0
Supplements: Fish oil (including cod liver oil) 2.0 2.6 6.8 -2.6 0.8 0.6
High cholesterol (Self-reported) 1.3 2.3 5.4 0.3 2.3 -1.1
Medication: Bendroflumethiazide 0.5 0.8 2.1 -0.4 0.4 1.4
Medication: Paracetamol 0.7 1.1 2.2 -1.5 0.0 1.0
Medication: Lisinopril 0.2 0.3 0.8 -0.2 0.9 -0.0
Medication: Atorvastatin 0.2 0.2 0.5 0.3 -0.3 -0.7
Illnesses of father: High blood pressure 0.3 0.3 0.9 -0.3 -0.9 0.2
Alcohol drinker status: Never 0.8 1.0 1.5 0.1 -1.2 -1.1
Ever smoked 0.7 1.3 3.0 -0.4 -1.7 -0.9
Basal metabolic rate 0.3 1.9 5.5 2.3 0.5 -0.0
Leg fat percentage (left) 0.1 0.5 0.7 -0.6 -0.7 0.8
Arm fat-free mass (left) 0.6 3.1 8.6 2.9 0.6 0.4
Number of operations (self-reported) 1.2 1.8 3.2 -0.1 -1.5 -1.8
Average weekly beer plus cider intake 1.3 1.8 3.2 -1.5 -1.8 -0.2
Irritability 0.9 1.6 2.7 -1.6 -1.2 0.7
Risk taking 0.4 0.6 1.4 1.2 -0.5 0.2
Ever had prostate specific antigen (PSA) test 1.9 2.2 4.5 0.6 -1.3 -2.1
Fractured/broken bones in last 5 years 0.3 0.3 0.5 0.2 -0.7 -0.7
Age started oral contraceptive pill 0.2 0.2 0.6 0.1 0.1 -0.8
Diastolic blood pressure, automated reading 0.2 0.5 1.1 1.0 0.5 0.4
Ever depressed for a whole week 0.4 0.5 0.7 -0.8 -0.6 -0.6
Unable to work because of sickness or disability 0.6 0.8 1.8 0.7 -0.1 -1.3
Commuting to job workplace: Cycle 1.5 1.8 4.1 2.0 -0.6 1.0
Myopia 1.3 1.9 3.7 0.5 1.9 1.3
Vascular/heart problems diagnosed by doctor 0.1 0.4 0.6 -0.4 -0.8 -0.6
Cholesterol lowering medication 1.5 2.3 3.9 0.3 2.0 -1.7
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 -0.4 -0.2 0.3
Pain experienced in last month 0.5 0.9 1.5 1.0 1.2 -0.3
Supplements: Calcium 1.3 1.4 3.2 -1.8 -1.0 0.4
Basal cell carcinoma (self-reported) 2.6 3.1 5.7 1.9 2.4 -0.2
Heart attack/myocardial infarction (self-reported) 2.1 2.7 4.7 0.0 1.8 2.2
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.5 -0.3 -0.4 -0.7
Heart disease (siblings) 1.7 2.0 5.1 -2.3 1.0 -0.2
Alcohol drinker status: Previous 1.1 1.3 2.5 1.6 -0.9 0.8
Pack years of smoking 0.0 0.0 0.1 -0.2 0.2 -0.0
Impedance of whole body 0.5 2.8 6.5 -2.5 -1.4 -0.1
Leg fat mass (left) 0.1 0.3 0.5 0.7 -0.5 0.2
Arm predicted mass (left) 0.6 3.1 8.6 2.9 0.7 0.4