Hub : Genes

GPR132

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0950	0.0340	5.3e-04	0.001	NA	0.046	NA	0.000	2.7e-01	NA	1.2e-04	NA	3.2e-01
2	GTEx	Heart Left Ventricle	0.1007	0.0442	6.0e-03	0.025	NA	0.001	NA	0.008	1.6e-02	NA	2.8e-01	NA	1.1e-01
3	GTEx	Lung	0.1063	0.0439	3.0e-03	0.024	NA	0.035	NA	0.051	6.1e-03	NA	1.1e-03	NA	9.0e-05
4	GTEx	Nerve Tibial	0.1026	0.0386	8.1e-04	0.117	NA	0.061	NA	0.089	1.3e-08	NA	3.8e-05	NA	7.2e-07
5	GTEx	Skin Not Sun Exposed Suprapubic	0.2070	0.0600	2.3e-04	-0.001	NA	0.028	NA	0.009	3.5e-01	NA	1.1e-02	NA	1.0e-01
6	GTEx	Skin Sun Exposed Lower leg	0.1540	0.0450	8.7e-06	0.091	NA	0.094	NA	0.095	5.4e-08	NA	3.6e-08	NA	2.9e-08
7	GTEx	Stomach	0.1230	0.0490	2.2e-03	-0.006	NA	-0.006	NA	-0.006	9.9e-01	NA	1.0e+00	NA	8.5e-01
8	GTEx	Thyroid	0.1030	0.0350	7.0e-05	0.133	NA	0.120	NA	0.132	2.2e-10	NA	2.0e-09	NA	2.9e-10
9	YFS	Blood	0.0128	0.0063	8.4e-03	0.003	0.007	0.000	0.007	0.002	3.5e-02	1.4e-03	2.9e-01	0.0015	5.8e-02
10	TCGA	Bladder Urothelial Carcinoma	0.0330	0.0220	4.8e-03	0.029	0.022	0.005	NA	0.015	1.7e-03	5.6e-03	1.2e-01	NA	1.8e-02
11	TCGA	Thyroid Carcinoma	0.0830	0.0410	2.2e-06	0.052	0.072	0.060	NA	0.056	8.6e-06	1.6e-07	1.8e-06	NA	3.9e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.3	2.0	5.4	-2.2	-0.9	0.0	-1.6	0.9	0.9	-1.8	0.9	2.3	1.5	0.8
Bipolar Disorder or Schizophrenia	0.3	0.8	3.1	-1.8	-0.3	0.0	-0.4	1.3	0.5	-1.2	0.0	1.4	0.3	-0.2
Depressed Affect (Nagel 2018)	3.2	6.8	13.5	-3.7	-3.0	-3.5	-2.6	-0.3	-0.2	-2.3	3.1	2.8	1.7	2.8
Depression (Nagel 2018)	4.2	6.3	10.5	-3.1	-2.5	-3.1	-2.8	-0.2	0.0	-2.5	3.2	2.5	2.5	2.4
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.9	-1.8	-1.7	0.4	-1.6	-2.0	-1.3	-1.9	0.6	1.2	0.2	0.7
Neuroticism (Nagel 2018)	1.2	2.8	10.1	-3.2	-1.9	-2.3	-1.3	0.1	-0.5	-1.2	1.5	1.7	1.0	1.6
Schizophrenia (2018)	0.2	0.4	0.9	-0.6	0.3	0.0	0.7	0.9	-0.0	-0.1	-0.7	-0.1	-0.9	-1.0
Schizophrenia vs Biploar Disorder	0.2	0.3	2.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.7	-0.8
Worry (Nagel 2018)	0.4	0.8	4.2	-2.1	-1.1	-1.2	-0.4	-0.2	-0.6	-0.1	0.2	0.4	-0.1	1.0
Alzheimer’s Disease (in mother)	0.7	0.8	2.0	-0.2	0.1	-0.6	-1.0	1.2	0.0	-1.4	0.9	1.3	1.3	0.3
Alzheimer’s Disease (in father)	0.3	0.3	0.8	-0.8	-0.2	0.0	-0.4	0.9	0.0	-0.7	0.2	0.9	0.3	0.1
Alzheimer’s Disease (including proxy)	1.9	2.7	5.4	-1.3	-1.1	-1.1	-2.2	0.8	0.1	-2.3	1.9	2.3	2.1	1.4
Crohns Disease (2017)	1.3	2.9	8.4	-0.3	-1.9	-0.6	-2.4	-1.4	0.8	-2.1	2.9	1.0	1.7	1.6
Irritable Bowel Disease (IBD)	3.7	8.8	21.0	-2.0	-3.0	-1.8	-4.2	-1.0	1.1	-3.7	4.6	2.3	3.5	3.0
Ulcerative Colitis (UC)	3.8	7.1	13.3	-2.7	-2.6	-1.8	-3.6	-0.3	0.9	-3.2	3.6	2.3	3.1	2.8
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.2	0.3	1.2	-0.9	-0.6	-0.0	-0.3	-0.1	-0.1	-1.1	0.1	-0.4	0.7	-0.2
Verbal and Numeric Reasoning (VNR)	1.5	3.7	11.5	-3.4	-2.0	-0.1	-1.9	-2.5	-1.3	-2.4	0.9	2.4	0.6	1.1
Breast Cancer	0.2	0.5	3.5	1.9	-0.1	-0.4	0.0	-0.8	0.8	-0.3	-0.1	-0.0	0.4	0.0
Ovarian Cancer	0.2	0.3	1.4	0.7	0.3	-1.2	0.1	-0.2	-0.6	0.6	0.4	-0.3	0.0	0.2
Prostate Cancer	0.3	0.5	1.3	0.3	0.6	-1.1	0.7	0.7	-0.1	1.1	0.7	-0.4	-0.6	0.2
Age at First Birth	0.1	0.2	0.8	-0.8	0.1	0.3	0.1	0.9	0.1	0.4	-0.2	-0.0	-0.3	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.5	2.0	7.9	0.7	0.6	0.0	0.6	-2.4	-2.8	-0.6	-0.3	0.2	-2.1	-1.5
Coronary Artery Disease (CAD)	0.0	0.0	0.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.4	-0.6
Crohns Disease (2012)	0.7	1.1	4.2	-0.2	-1.2	0.0	-1.7	-0.3	-0.1	-0.8	2.0	-0.3	0.9	1.3
Mean Putamen Volume	3.1	3.6	10.9	-3.3	-2.3	0.0	-2.4	-0.8	-0.8	-2.1	1.4	1.9	1.3	2.1
Fasting Glucose	0.8	1.0	3.0	-0.3	0.0	0.7	1.7	1.2	1.3	-0.7	1.4	0.7	1.2	0.4
HbA1C	0.3	0.3	1.3	1.0	-0.3	0.2	0.0	-0.7	1.1	-0.1	0.1	-0.3	0.5	0.6
HDL Cholesterol	0.6	1.0	4.0	-0.3	1.2	0.0	1.0	-0.7	-0.9	0.6	-1.2	0.2	-2.0	-1.1
LDL Cholesterol	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.4	-0.5	0.1
Lupus	3.0	4.6	10.0	2.5	2.2	-0.6	2.3	1.9	-0.9	3.2	-1.1	-2.8	-2.5	-1.9
Neuroticism (2016)	2.0	2.9	8.9	-3.0	-2.0	-0.9	-1.6	-1.4	-0.7	-2.2	1.5	1.8	1.2	1.2
Primary Biliary Cirrhosis	1.6	2.2	5.9	1.2	2.4	-0.3	2.0	1.2	-0.7	1.9	-0.8	-0.3	-2.1	-1.6
Rheumatoid Arthritis	0.4	0.5	2.2	-0.6	1.0	0.0	0.5	1.5	-0.3	1.0	0.4	-0.5	-0.2	-0.2
Schizophrenia (2014)	0.3	0.7	2.4	-0.4	0.7	0.0	1.0	1.5	0.2	0.5	-0.5	-0.9	-1.2	-0.9
Triglycerides	0.1	0.1	0.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.5	0.6	-0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.3	2.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.0	-1.4
Ulcerative Colitis	4.0	5.7	11.8	-2.6	-2.3	0.0	-3.2	-0.7	-0.2	-3.4	3.4	2.6	2.3	2.2
Blood Eosinophil Count	0.2	1.6	4.8	0.1	-2.2	-0.8	-1.8	-1.3	0.2	-0.9	1.4	0.4	1.5	1.7
Blood Platelet Count	1.4	15.8	50.8	-3.9	-3.3	-1.7	-4.2	5.5	4.7	1.5	2.7	-0.1	7.1	3.9
Blood Red Count	0.3	2.6	14.8	-0.1	0.3	0.0	0.3	3.9	1.1	3.0	-0.2	-1.5	1.2	-0.2
Blood White Count	0.4	3.1	7.8	-1.0	-2.8	-1.1	-2.7	-0.3	0.5	-0.9	1.7	0.7	2.7	2.2
Heel T-Score	0.2	1.8	8.9	-3.0	-0.4	-1.5	-0.5	1.5	2.2	0.2	0.5	0.4	0.8	0.8
BMI	0.6	3.2	9.6	-1.2	-2.1	-3.1	-2.2	-1.0	-1.5	-0.5	2.3	-0.1	0.6	2.4
Height	0.1	2.6	22.8	-4.8	-0.4	-0.3	0.5	0.3	-0.5	-0.0	-2.0	0.6	-0.2	-0.2
Waist Hip Ratio (WHR)	0.5	2.2	4.5	-0.2	-1.8	-1.2	-1.7	0.9	1.9	-0.3	1.8	0.5	2.1	2.1
Systolic Blood Pressure	0.2	1.0	3.8	-2.0	-0.4	-1.4	-0.1	0.1	1.2	-0.5	-0.1	1.3	0.9	0.5
Smoking Status	1.7	4.0	7.7	2.8	2.2	0.8	1.9	2.5	1.4	2.6	-0.9	-2.6	-1.2	-1.7
Allergy or Eczema	1.6	4.1	9.7	1.1	2.3	0.3	2.9	1.4	0.1	2.4	-2.4	-3.1	-1.5	-2.2
Cardiovascular Disease	0.3	0.9	5.1	0.2	0.2	-2.3	0.8	0.4	1.6	1.2	-0.3	0.1	-0.0	0.1
Hypothyroidism (self reported)	1.7	3.9	12.5	3.5	1.8	-0.3	2.5	-0.3	-1.2	1.6	-1.6	-2.7	-2.0	-1.5
Respiratory disease	2.7	6.0	13.7	3.2	2.8	2.0	2.8	1.3	0.5	2.7	-2.4	-3.7	-1.6	-2.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	5.1	-0.0	-0.2	-2.3	-0.7	0.0	-0.4	0.8	1.5	-0.7	0.5	1.1
Lung FEV1/FVC ratio	0.3	1.7	5.1	0.1	-1.7	-1.8	-1.4	-2.3	-1.0	-1.1	1.2	0.4	0.2	1.3
Lung FVC	0.6	3.2	16.9	4.1	1.7	0.4	1.9	0.4	-0.4	-0.3	-1.6	-1.5	-1.0	-2.3
Neuroticism	0.9	2.2	9.1	-3.0	-1.7	-2.2	-1.1	-0.6	0.1	-0.7	1.2	1.0	0.4	1.5
Chronotype (morning person)	1.7	3.8	13.1	3.6	1.4	2.9	1.6	-0.7	-1.1	0.9	-1.7	-2.5	-1.3	-1.7
Hair Pigment	0.0	1.2	4.3	2.1	1.6	-0.3	1.1	0.9	-0.5	0.6	-0.5	-0.4	-1.3	-1.4
Tanning	0.6	7.2	22.0	0.4	2.2	1.9	3.1	-0.1	-3.5	2.3	-2.9	-2.4	-4.7	-2.7
Hand grip strength (left)	0.5	1.4	8.6	2.9	1.5	-0.4	1.0	0.3	0.3	0.5	-0.8	-1.2	-0.6	-0.9
Number of treatments/medications taken	0.3	0.6	2.2	-1.5	-0.3	-1.0	0.0	0.3	0.1	1.0	-0.4	-1.3	-0.2	0.5
Average weekly spirits intake	1.0	1.2	7.6	0.5	-1.3	-2.7	-0.7	-0.1	0.9	-0.8	1.1	0.2	0.6	0.8
Sensitivity / hurt feelings	0.3	0.6	1.1	0.4	0.2	0.3	0.9	-0.9	-1.0	0.9	-0.5	-1.0	-1.0	-0.7
Frequency of depressed mood in last 2 weeks	1.7	2.4	10.7	-3.3	-0.9	-1.6	-1.1	0.7	0.3	-1.8	1.2	1.7	1.5	0.3
Hearing difficulty/problems: Yes	4.1	6.3	14.5	2.6	3.1	2.3	3.0	1.4	-0.7	1.9	-3.2	-1.3	-2.3	-3.8
Relative age of first facial hair	0.3	0.7	2.0	1.1	0.6	0.8	0.8	-0.1	-0.7	-0.6	-1.4	-0.2	-0.5	-1.3
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	1.1	-0.4	-0.4	0.9	-0.4	-1.0	-0.0	0.0	-0.2	-1.1	0.2	0.6
Ever used hormone-replacement therapy (HRT)	0.5	0.7	4.1	-0.4	-0.2	-2.0	-0.6	-0.7	-1.0	-0.3	1.1	0.2	-0.1	0.0
Ever had hysterectomy (womb removed)	1.0	1.1	4.1	-0.6	-0.6	-1.3	-1.3	0.4	-1.6	-0.2	2.0	-0.1	-0.5	0.9
Systolic blood pressure, automated reading	0.4	1.0	2.8	-1.7	-1.2	-1.6	-0.5	0.9	0.7	-0.6	0.5	0.7	1.0	1.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.6	0.1	-0.4	-0.1	0.1	0.1	-0.8	0.1	-0.1	-0.4	-0.2	-0.0
Angina	0.5	0.7	2.8	-0.6	-0.6	0.4	-0.1	-1.4	-1.4	0.3	-0.0	-0.2	-1.7	-0.1
Medication for hormone replacement therapy	0.2	0.2	0.8	0.2	-0.4	-0.6	-0.7	-0.9	-0.4	0.1	0.1	-0.1	-0.1	0.7
Vitamin and mineral supplements	1.0	1.4	6.7	-0.7	-0.3	-1.7	-0.1	-1.0	-2.6	-1.2	0.2	0.9	-1.4	-0.1
Supplements: Zinc	0.4	0.4	1.1	-0.4	0.4	1.0	0.6	-0.3	0.7	0.6	-0.6	-0.9	0.1	-0.6
Medication: Co-codamol	0.3	0.3	1.5	-1.2	-0.0	-0.4	-0.3	0.6	-0.3	0.9	0.2	-0.2	-0.2	0.5
Medication: Metformin	0.4	0.6	2.4	0.4	0.8	-0.1	0.2	1.3	0.3	1.5	-0.1	-1.2	0.1	-0.0
Diabetes (father)	1.0	1.2	2.9	0.7	-0.2	-1.4	-0.5	0.8	1.0	1.2	1.4	-1.7	1.0	1.3
Diabetes (mother)	1.6	2.1	4.5	-0.8	-1.6	-1.8	-1.4	1.1	1.6	0.2	1.3	0.1	2.1	2.0
Severe depression (siblings)	0.6	0.7	1.4	-0.7	-0.7	-1.2	-0.8	1.2	0.7	-0.3	1.0	0.3	0.5	1.0
Pack years adult smoking proportion	2.7	4.1	6.9	-2.3	-2.2	-2.6	-2.1	0.2	1.6	-1.6	1.7	2.3	2.3	2.1
Impedance of leg (right)	1.2	6.0	17.0	1.6	3.1	4.1	3.1	0.9	1.5	2.4	-2.9	-1.2	-1.1	-2.6
Leg fat-free mass (left)	0.7	3.8	11.5	-2.6	-2.5	-3.4	-2.1	-1.2	-1.6	-1.0	1.5	0.4	0.4	2.4
Trunk fat percentage	0.3	1.2	4.9	-2.2	-1.3	-0.8	-1.2	-1.0	-1.4	-0.1	-0.0	0.6	-0.0	1.3
Hand grip strength (right)	0.5	1.2	7.2	2.7	1.5	-0.4	0.8	1.0	0.5	0.3	-0.6	-0.8	-0.1	-1.0
Townsend deprivation index at recruitment	0.6	0.9	2.6	0.5	1.0	1.6	1.0	-1.2	0.5	-0.0	-0.8	0.5	-1.0	-1.1
Current tobacco smoking	0.8	1.2	6.5	0.8	0.5	-0.6	0.5	1.8	2.6	0.8	0.0	-0.2	1.2	-0.7
Average weekly fortified wine intake	0.8	0.9	1.8	-0.4	-0.9	-0.7	-1.3	0.8	1.3	-0.5	1.3	0.2	1.3	1.0
Maternal smoking around birth	0.8	1.2	2.5	1.5	1.2	0.9	1.1	0.6	-0.9	1.6	-0.8	-1.0	-0.9	-1.2
Fed-up feelings	2.9	5.2	14.3	-3.8	-2.5	-3.1	-2.2	-1.0	-0.5	-2.3	2.4	2.2	1.3	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	3.5	4.6	11.5	-1.9	-1.9	-3.4	-2.2	0.9	1.3	-1.4	2.8	1.6	2.5	2.5
Relative age voice broke	0.8	1.2	7.4	2.7	0.6	0.7	1.1	0.6	0.8	-0.1	-1.0	0.3	0.0	-1.3
Taking other prescription medications	0.2	0.4	1.5	-1.1	0.0	-1.2	0.1	0.7	-0.1	0.1	-0.4	-0.5	0.2	0.6
Age when periods started (menarche)	0.3	0.8	2.5	0.3	1.6	0.7	1.3	0.4	0.3	1.2	-0.9	-1.0	-0.4	-0.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.5	0.4	-0.1	-1.4	-0.1	0.2	-1.6	0.1	1.0	-1.1	-0.6	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	-0.6	-0.0	0.3	-0.0	-1.0	-0.6	1.0	-0.9	0.2	-1.0	-0.0
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	3.6	1.8	1.9	0.4	1.4	1.7	1.0	1.2	-1.0	-1.3	-0.2	-1.5
Qualifications: CSEs or equivalent	0.2	0.3	1.4	-0.1	0.0	-0.9	-0.2	-1.2	0.5	0.3	0.5	-0.6	0.1	0.5
Serious illness, injury or assault to yourself	0.2	0.2	1.6	-1.2	0.1	-0.7	-0.1	-0.1	0.1	0.3	0.1	-0.1	0.3	0.3
High blood pressure	0.2	0.6	2.1	-0.3	-0.1	-1.4	0.6	1.0	1.4	1.0	-0.5	-0.0	0.4	0.6
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.7	0.1	1.7	0.1	1.9	1.0	0.6	1.3	-1.2	-1.1	-0.5	-1.5
Multivitamins +/- minerals	0.4	0.5	2.1	0.3	-0.2	1.5	-0.3	0.1	1.3	0.4	0.2	-0.4	1.1	0.3
Stomach or abdominal pain in last month	3.2	4.0	8.9	-1.0	-0.9	-2.6	-1.6	1.7	3.0	-0.3	2.4	2.0	2.7	2.1
Supplements: Glucosamine	0.3	0.4	2.5	1.6	-0.0	0.3	-0.1	-0.0	-0.8	-0.8	-0.4	-0.0	-0.1	-0.4
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.9	-0.4	1.2	-0.9	1.0	1.0	-0.4	0.9	-0.7	-0.9	-1.4	-0.6
Medication: Atenolol	0.4	0.5	2.0	-1.4	0.0	-0.1	0.2	-1.0	-0.7	-0.6	-0.3	0.2	-0.7	-0.7
Medication: Levothyroxine sodium	0.4	0.7	2.2	1.4	0.6	-0.9	1.0	-0.2	0.2	1.0	-0.5	-1.5	-0.5	-0.2
Sitting height	0.3	2.1	7.8	-2.8	-2.5	-1.1	-1.6	-1.0	-0.5	-0.7	0.6	0.9	0.7	1.6
Chronic bronchitis/emphysema (father)	1.3	1.5	5.4	-0.5	1.2	-0.2	1.0	-1.3	-2.3	0.7	-0.6	-0.3	-2.2	-0.9
High blood pressure (mother)	0.4	0.6	2.3	-1.5	0.3	-1.4	0.6	1.2	0.1	-0.1	-0.3	-0.0	-0.0	0.3
Body mass index (BMI)	0.8	3.5	9.4	-1.6	-2.2	-3.1	-2.3	-1.6	-2.2	-0.8	1.5	0.9	-0.0	2.2
Impedance of leg (left)	1.3	6.4	20.7	1.4	3.2	4.6	3.0	1.2	2.1	2.1	-3.0	-0.8	-0.6	-2.8
Leg predicted mass (left)	0.7	3.8	11.2	-2.6	-2.5	-3.4	-2.2	-1.2	-1.6	-1.1	1.5	0.4	0.4	2.4
Trunk fat mass	0.5	2.1	6.9	-2.6	-1.8	-1.6	-1.7	-1.1	-1.6	-0.5	0.4	0.7	0.2	1.7
Waist circumference	1.2	4.3	8.1	-2.6	-2.9	-2.6	-2.8	-1.1	-1.1	-1.1	2.0	1.0	1.2	2.8
Number of incorrect matches in round	2.0	3.4	8.6	2.9	2.0	1.5	2.4	1.6	0.1	1.9	-1.8	-0.8	-1.5	-2.1
Past tobacco smoking	2.4	4.4	8.2	-2.6	-2.0	-1.9	-2.1	-1.8	0.1	-2.5	1.5	2.9	2.4	2.0
Alcohol usually taken with meals	0.3	0.4	1.5	1.2	0.6	0.2	-0.1	0.5	0.8	-0.3	0.5	-0.1	1.2	-0.6
Nervous feelings	0.2	0.4	1.8	-1.3	-0.8	-0.9	-0.0	0.2	0.9	0.3	0.1	-0.1	0.7	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.8	-0.8	0.6	-0.9	-0.1	0.2	-0.6	-0.1	0.4	-0.4	-0.1	-0.4
Hearing difficulty/problems with background noise	0.4	0.6	2.3	-0.2	0.4	0.2	1.1	0.9	-0.8	0.6	-1.5	0.1	-0.8	-0.9
Hair/balding pattern: Pattern 2	2.9	3.6	6.6	-2.1	-2.0	-1.9	-2.0	-2.6	-1.4	-1.9	2.1	1.9	0.7	1.8
Had menopause	0.6	0.8	2.8	-1.0	-0.5	-1.7	-0.7	1.3	0.1	-0.4	0.9	0.4	0.9	0.7
Had other major operations	0.2	0.3	1.5	-1.2	-0.7	0.2	-0.6	-0.3	0.2	-0.5	0.0	0.4	0.4	-0.2
Forced vital capacity (FVC)	0.1	0.3	0.6	0.4	0.0	-0.8	0.3	-0.7	-0.6	-0.7	-0.7	-0.3	-0.1	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.4	-0.9	0.1	0.4	0.4	0.0	0.1	1.5	-1.3	0.1	-0.8	-0.1
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	11.6	-2.5	-1.5	-3.4	-0.7	-0.8	-1.2	-1.1	1.5	0.7	0.1	1.0
Qualifications: None of the above	0.5	1.1	4.1	0.0	-1.4	-0.9	-1.0	-0.5	-0.3	-1.4	0.9	2.0	0.2	1.1
Financial difficulties in last 2 years	0.5	0.7	3.8	1.9	0.6	-0.9	0.4	-1.3	0.6	-0.0	-0.2	-0.4	-0.1	-0.1
Mouth/teeth dental problems	0.8	1.2	4.1	-0.5	-1.7	-0.1	-1.4	-2.0	-0.8	-0.5	0.8	0.2	0.1	1.5
Heart attack	0.5	0.6	2.2	-1.0	-0.7	-0.9	-0.3	-0.9	-1.5	-1.0	0.4	0.1	-0.6	0.1
Allergy	0.9	2.1	4.7	-0.9	-2.0	-0.0	-2.2	-1.4	-1.0	-2.1	1.4	1.7	0.5	1.4
Pain all over the body in last month	1.3	1.4	5.1	0.0	-1.0	-2.3	-1.2	-0.2	0.1	-0.4	1.7	-0.3	0.9	1.9
Diabetes (self-reported)	0.1	0.2	0.5	-0.7	0.2	-0.1	-0.2	-0.0	-0.4	0.6	0.7	-0.5	-0.1	0.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.2	-0.7	0.6	0.3	0.8	-0.1	1.1	0.5	-0.3	0.1	0.4	-0.7
Medication: Ramipril	0.1	0.1	0.9	-1.0	0.1	-0.2	0.3	0.1	0.6	0.2	-0.3	-0.1	0.2	0.2
Medication: Simvastatin	0.8	1.1	4.1	-0.3	-0.1	-0.6	0.9	-0.2	-1.5	1.1	-0.4	-1.6	-2.0	-0.4
Fluid intelligence score	0.2	0.5	3.4	-1.8	-0.7	-0.1	-0.5	-0.7	-0.2	-0.6	-0.2	0.1	0.5	0.2
Illnesses of siblings	0.2	0.3	2.4	0.3	-0.0	0.2	0.0	-1.6	-0.0	0.1	-0.2	-0.0	-0.4	0.6
Neuroticism score	0.6	1.2	6.6	-2.6	-1.3	-1.6	-0.5	-0.3	-0.1	-0.5	0.7	0.5	0.4	1.0
Weight	0.8	4.0	8.9	-3.0	-2.6	-2.8	-2.4	-1.6	-1.8	-1.0	1.2	0.8	0.4	2.4
Impedance of arm (right)	0.3	1.2	6.4	-0.0	1.2	2.5	1.3	0.2	1.0	0.4	-1.2	-0.2	0.4	-1.0
Arm fat percentage (right)	0.8	3.0	5.2	-2.1	-2.1	-2.1	-2.2	-1.7	-2.3	-0.9	1.1	0.9	-0.0	2.0
Trunk fat-free mass	0.4	2.0	7.2	-2.2	-1.9	-2.7	-1.4	-0.3	-0.9	-0.7	0.8	0.2	0.1	1.5
Hip circumference	0.8	3.5	7.1	-2.7	-2.4	-2.0	-2.4	-1.2	-1.7	-1.3	1.2	1.3	0.8	2.3
Time employed in main current job	1.1	1.3	5.1	-0.7	2.3	0.4	1.7	0.6	0.5	0.0	-0.9	0.2	-0.6	-2.0
Alcohol intake versus 10 years previously	1.2	1.8	3.5	-0.1	-1.6	-1.8	-1.8	-1.3	-1.2	-1.0	1.9	0.4	0.7	1.4
Father’s age at death	0.5	0.6	2.0	0.7	-0.6	0.3	-1.2	-0.2	-0.1	-1.4	1.3	-0.2	0.5	0.5
Worrier / anxious feelings	0.1	0.2	0.9	-0.7	-0.4	-0.8	0.1	0.2	-0.5	0.5	0.1	-0.9	-0.2	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	4.7	-2.2	-0.4	-2.1	-0.7	1.1	0.9	-0.3	0.9	0.4	1.1	1.2
Falls in the last year	0.3	0.4	2.5	-0.1	-0.1	-0.3	0.1	0.9	1.6	0.5	-0.5	0.4	0.6	0.1
Hair/balding pattern: Pattern 3	1.5	2.2	4.4	1.1	2.1	1.0	2.0	1.6	0.9	1.3	-1.5	-1.7	-0.6	-1.7
Number of live births	0.1	0.2	1.0	0.8	0.1	-1.0	0.5	0.2	-0.3	-0.2	-0.1	0.2	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.9	0.2	-0.7	-1.6	-0.6	-1.7	-1.1	-1.4	0.2	0.2	0.1	0.2
Pulse rate	1.0	1.6	4.6	-0.7	-1.5	-1.2	-1.7	0.9	0.1	-0.2	2.1	-0.0	0.9	2.1
Happiness	0.5	0.6	2.2	-0.0	0.7	-0.2	0.7	1.2	0.2	0.9	-0.8	-1.5	-0.3	-1.0
Noisy workplace	0.7	0.8	4.6	-0.2	-0.6	-2.1	0.3	1.6	0.8	-0.0	-0.0	0.7	0.6	0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.9	-0.3	-0.7	0.3	-1.2	-0.5	-0.6	-1.0	0.5	1.4	0.5	0.9
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	4.1	-0.3	1.4	-1.4	0.6	2.0	1.6	1.1	-0.2	-0.1	0.8	-0.4
Mouth/teeth dental problems: Dentures	0.9	1.6	3.5	-0.2	1.4	-0.3	1.9	1.3	0.2	1.4	-1.2	-1.1	-1.7	-1.6
Asthma	2.4	4.8	11.8	2.9	2.4	1.7	2.5	1.5	1.1	2.8	-1.9	-3.4	-0.7	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	3.4	-1.8	-0.3	0.5	-0.7	-0.6	0.2	0.3	0.1	0.1	-0.1	0.3
Medication: Cholesterol lowering	1.1	1.7	10.1	-0.3	-0.6	-0.5	0.2	-1.8	-3.2	-0.2	0.0	-0.3	-2.2	-0.0
Depression (self-reported)	0.9	1.0	4.7	-1.2	-0.9	-2.2	-0.9	-0.0	-0.7	-1.2	0.9	0.9	0.4	0.4
Medication: Lansoprazole	0.9	1.0	3.9	-0.6	-0.5	0.3	-0.2	-2.0	1.4	-1.4	-0.6	1.3	0.9	-0.3
Prospective memory result	0.5	0.7	4.0	1.1	-0.5	-0.5	-0.4	0.2	2.0	0.1	0.3	0.3	1.0	0.6
Lung cancer (father)	2.4	2.9	9.1	-3.0	-2.2	-1.9	-1.6	-1.2	-0.7	-0.6	1.9	1.5	0.2	1.7
Illnesses of mother	1.1	1.3	7.1	2.7	1.1	0.5	0.6	-1.1	0.4	1.1	-1.0	-0.9	-0.8	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.9	0.6	-1.0	-1.4	-0.9	-1.7	-0.8	-1.6	0.6	0.0	0.3	0.4
Pulse wave Arterial Stiffness index	0.2	0.2	1.1	-1.1	-0.4	0.2	0.1	0.3	-0.2	0.6	-0.0	-0.1	0.1	0.4
Impedance of arm (left)	0.3	1.4	6.6	-0.0	1.4	2.6	1.4	0.4	0.8	0.7	-1.3	-0.6	-0.0	-1.1
Arm fat mass (right)	1.0	4.3	8.5	-2.8	-2.4	-2.9	-2.5	-1.5	-2.1	-1.1	1.6	1.2	0.4	2.4
Trunk predicted mass	0.3	1.8	7.0	-2.1	-1.8	-2.6	-1.3	-0.3	-1.0	-0.5	0.8	0.0	0.0	1.4
Standing height	0.1	1.2	10.3	-3.2	-1.0	-0.1	-0.2	0.0	0.4	-0.4	-0.7	0.1	0.7	0.5
Length of working week for main job	0.3	0.4	1.6	0.5	0.7	-1.3	0.2	0.3	0.9	0.4	0.4	0.0	0.5	0.4
Exposure to tobacco smoke at home	0.5	0.5	2.0	0.2	-0.3	-0.5	-0.1	1.1	1.4	0.1	-0.1	0.4	1.4	0.5
Breastfed as a baby	0.7	0.8	2.7	-0.5	0.1	1.6	-0.2	0.5	1.3	-0.5	-0.3	1.4	1.2	-0.6
Tense / ‘highly strung’	1.6	2.7	4.9	-0.4	1.7	1.5	2.2	0.4	-1.3	1.6	-1.7	-1.8	-2.2	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	4.7	-1.5	-0.3	-2.2	0.0	-0.2	-1.6	-0.8	0.7	0.1	-0.6	0.0
Hair/balding pattern: Pattern 4	2.8	6.7	9.7	2.8	2.9	3.1	2.5	0.6	-1.0	2.9	-2.9	-3.1	-2.8	-2.4
Birth weight of first child	2.0	3.6	6.9	1.0	1.6	2.2	1.6	0.3	-1.7	1.8	-2.6	-2.6	-2.4	-1.9
Peak expiratory flow (PEF)	0.7	1.5	6.1	0.3	-0.8	-0.8	-1.1	-2.5	-1.7	-2.1	0.4	0.7	-0.1	0.1
Pulse wave reflection index	0.5	0.6	2.6	-0.0	0.2	0.5	1.1	0.2	-0.1	0.4	-1.6	-0.3	-0.9	-1.0
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.9	-0.7	-2.2	-0.6	-1.3	-1.3	-0.5	-1.6	0.7	2.2	0.2	1.0
Loud music exposure frequency	0.7	0.8	2.2	-0.2	0.7	-0.1	1.2	0.5	-1.5	0.5	-0.8	-0.6	-1.4	-1.1
Qualifications: O levels/GCSEs or equivalent	1.5	2.5	4.9	-2.2	-2.0	-1.3	-1.7	-1.2	-0.0	-2.1	1.1	1.7	1.3	1.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.7	0.5	-0.5	-0.7	-0.8	0.0	-0.6	-1.2	0.5	1.3	0.7	0.5
Blood clot in the leg (DVT)	1.0	1.2	3.1	-0.7	-1.5	-1.8	-1.3	-0.7	-1.1	-1.1	0.9	1.1	0.4	1.1
Medication: Paracetamol	0.5	0.9	3.1	-1.8	-0.4	-0.9	-1.0	0.1	0.3	-0.5	1.1	0.7	1.4	0.9
Headache pain in last month	2.2	3.8	7.7	-2.8	-1.8	-1.9	-2.5	-0.3	0.2	-1.9	2.2	1.9	1.8	2.3
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	4.6	0.3	0.1	0.4	-0.8	0.9	2.1	0.2	0.7	0.0	1.7	0.6
Glaucoma (self-reported)	0.6	0.7	2.5	-1.6	-0.5	-0.6	-0.5	-1.3	-1.0	-1.0	0.5	0.6	-0.3	0.1
Gout (self-reported)	1.1	1.5	4.8	0.1	-1.3	-0.6	-1.3	-2.2	-0.6	-1.8	0.9	1.1	0.5	1.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	4.5	2.1	0.9	-0.8	1.4	-0.5	-1.1	0.8	-0.5	-1.7	-1.3	-0.5
Medication: Amlodipine	1.0	1.4	3.2	1.2	1.6	0.7	1.7	-0.5	-0.1	1.0	-1.3	-0.7	-1.1	-1.8
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.1	0.7	0.9	0.6	0.5	1.4	1.3	1.4	-0.1	-1.2	0.1	-0.1
Birth weight	0.9	2.0	4.5	1.2	1.8	1.4	2.1	0.7	-0.4	0.9	-1.2	-1.0	-1.5	-2.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.9	-1.0	-1.0	0.3	-0.6	-0.8	-0.6	0.5	1.3	-0.3	0.3	1.4
High blood pressure (siblings)	1.2	1.7	6.1	-2.2	-1.1	-0.3	-0.9	1.0	0.5	-1.6	0.5	2.5	1.4	0.3
Forced vital capacity (FVC), Best measure	0.2	0.6	2.5	0.0	-1.0	-0.8	-0.7	-0.6	-0.2	-1.6	0.5	0.3	0.8	0.2
Body fat percentage	0.3	1.4	4.2	-2.0	-1.3	-0.9	-1.3	-1.4	-1.5	-0.2	0.1	0.7	-0.1	1.3
Leg fat percentage (right)	0.3	1.0	2.2	-1.4	-1.0	-1.1	-1.3	-1.3	-1.1	0.4	0.3	0.5	-0.2	1.5
Arm fat-free mass (right)	0.3	1.6	7.4	-1.9	-1.5	-2.7	-1.2	-0.0	-0.6	-0.0	0.7	-0.1	0.2	1.5
Exposure to tobacco smoke outside home	0.4	0.5	1.1	0.7	-0.7	-0.8	-0.4	0.7	0.9	0.1	0.9	0.3	1.1	0.9
Comparative body size at age 10	0.6	1.7	4.7	0.4	-1.9	-2.2	-1.5	-1.0	-0.7	-0.9	1.2	0.3	0.7	1.9
Number of full brothers	2.3	2.9	7.2	2.1	2.0	0.8	1.6	-0.5	-1.9	0.5	-1.7	-0.1	-2.7	-2.4
Worry too long after embarrassment	0.3	0.5	1.8	-0.6	0.5	0.7	1.4	0.4	0.4	0.7	-1.1	-0.3	-0.4	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.1	6.3	-2.5	-2.0	-2.0	-1.5	-0.9	-0.3	-0.5	1.5	0.6	0.4	1.7
Wheeze or whistling in the chest in last year	1.6	2.8	9.0	-0.1	1.3	1.1	1.1	3.0	1.9	2.7	-1.1	-2.3	0.3	-0.2
Number of children fathered	1.4	1.6	6.3	-1.8	-0.9	-2.5	-0.9	1.2	-0.1	-0.1	1.8	-0.5	0.3	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.8	-0.6	-1.0	-0.9	-1.0	-0.6	0.0	-0.5	1.4	0.2	0.9	1.3
Age at first live birth	0.5	0.9	3.6	0.4	-1.0	-0.2	-0.6	0.5	1.4	-0.1	0.7	0.4	1.9	1.5
Pulse wave peak to peak time	0.1	0.2	0.7	0.8	0.4	-0.0	-0.2	-0.5	0.1	-0.7	0.1	0.1	-0.0	-0.4
Health satisfaction	1.1	1.5	4.3	-2.1	-1.3	-2.0	-0.9	1.2	-0.5	-0.5	1.0	0.8	0.7	1.1
Shortness of breath walking on level ground	0.3	0.3	1.1	0.4	-0.2	-0.3	-0.3	-0.3	0.8	-0.8	0.6	1.0	0.8	-0.0
Qualifications: College or University degree	0.4	1.2	2.8	-0.9	-1.3	0.3	-1.7	0.3	0.4	-1.1	1.4	1.0	1.4	1.2
Eye problems/disorders: None of the above	0.4	0.5	3.2	-0.0	0.6	-0.4	-0.4	0.2	-0.4	-0.9	0.1	1.8	0.5	-0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.5	3.2	-0.7	-0.9	-1.8	-0.1	-0.2	-0.3	-0.6	0.5	0.4	-0.4	0.5
Emphysema/chronic bronchitis	0.6	0.7	3.8	-0.2	0.0	-0.8	0.0	1.7	1.9	0.1	-0.2	0.2	0.9	0.1
Medication for pain relief, constipation, heartburn	0.9	1.5	8.2	2.9	1.3	1.1	1.0	-0.0	-0.4	0.4	-0.4	-0.7	-1.3	-1.2
Neck or shoulder pain in last month	0.4	0.6	1.3	-0.3	-0.3	0.9	-1.0	0.3	1.2	-0.2	0.8	1.1	1.1	0.6
Medication: Blood pressure	0.5	0.9	4.7	-0.8	-0.2	-1.1	0.7	-0.5	-2.2	-0.4	-0.4	0.1	-1.3	-0.3
Angina (self-reported)	0.5	0.7	2.8	-0.6	-0.7	0.3	-0.2	-1.4	-1.3	0.4	0.1	-0.4	-1.7	0.0
Migraine (self-reported)	0.5	0.6	3.7	-0.6	0.6	-0.2	0.6	1.9	1.0	0.4	-0.5	0.3	0.5	-0.3
Medication: Ibuprofen	0.5	0.6	3.9	-2.0	-0.7	0.4	-0.6	-1.2	0.1	-0.2	0.1	0.2	-0.4	0.1
Medication: Allopurinol	1.0	1.4	2.5	-0.8	-1.4	-0.7	-1.6	-1.2	-1.3	-1.5	0.8	1.2	0.5	1.4
Medication: Omeprazole	1.1	1.3	8.2	-2.9	-1.4	-0.7	-1.0	-0.2	-0.1	-0.6	-0.4	0.9	0.6	1.1
Medication: Seretide 50 evohaler	0.5	0.6	1.9	0.4	-0.7	0.7	-0.7	-1.1	-0.7	-1.4	0.5	0.8	0.6	0.3
Mean time to correctly identify matches	0.4	0.7	2.1	-1.3	-1.5	0.0	-0.8	-0.2	0.2	-1.3	0.5	0.1	1.0	0.5
Heart disease (mother)	0.4	0.4	2.4	-1.5	-0.2	-0.3	0.3	1.1	-0.6	-0.2	0.2	-0.7	-0.2	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.7	1.0	1.1	1.5	0.6	0.0	-0.3	0.2	-1.4	-0.1	-0.4	-1.6
Whole body fat mass	0.5	2.2	5.9	-2.4	-1.8	-1.7	-1.8	-1.2	-1.4	-0.7	0.5	0.8	0.3	1.8
Leg fat mass (right)	0.5	1.9	4.4	-2.1	-1.5	-1.9	-1.6	-1.3	-1.5	-0.1	0.6	0.5	-0.1	1.8
Arm predicted mass (right)	0.3	1.5	7.4	-2.0	-1.4	-2.7	-1.1	-0.0	-0.6	-0.1	0.7	0.0	0.2	1.3
Pulse rate, automated reading	0.2	0.7	2.8	0.2	-1.1	-0.5	-0.8	0.4	-0.1	0.4	1.5	-0.8	0.1	1.7
Alcohol intake frequency.	1.1	2.6	6.8	-2.3	-1.8	-1.5	-1.7	-0.2	-0.9	-1.6	1.5	2.6	0.8	1.5
Comparative height size at age 10	0.4	2.3	9.0	-3.0	-1.8	-0.6	-1.6	-1.1	-1.0	-1.1	1.0	1.2	0.5	1.9
Number of full sisters	0.3	0.4	1.7	1.1	0.5	0.1	0.2	0.4	1.3	0.7	-0.1	-0.6	0.3	0.3
Suffer from ‘nerves’	0.3	0.4	1.7	-1.2	-0.9	-1.3	0.0	0.3	0.2	-0.1	-0.1	0.5	0.2	0.5
Overall health rating	0.3	0.7	4.9	-1.0	-0.0	-2.2	0.1	0.6	-0.7	-0.3	0.5	-0.4	-0.3	0.1
Chest pain or discomfort	1.4	2.1	4.8	-1.8	-1.9	-1.4	-1.6	-0.7	0.6	-0.3	1.9	0.7	1.1	2.2
Had major operations	0.8	0.9	2.5	0.2	0.4	-0.1	1.0	-0.4	-1.6	0.6	-1.4	-1.5	-1.1	-0.8
Age at last live birth	0.5	0.7	4.1	0.4	0.1	-0.2	0.2	0.5	2.0	0.2	-0.2	1.0	1.5	0.4
Family relationship satisfaction	0.9	1.2	3.1	-1.1	-1.1	-1.8	-1.3	0.6	0.2	-0.6	1.1	0.2	1.5	1.1
Leg pain on walking	0.5	0.6	2.5	-0.9	-0.8	-1.6	-0.0	0.6	-0.3	-0.6	-0.4	1.2	0.1	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.8	1.4	1.0	-0.3	0.5	-0.5	-0.7	0.9	-0.2	-1.1	-1.0	-0.4
Commuting to job workplace: Car/motor vehicle	2.0	2.3	4.9	-1.0	-2.2	-2.0	-1.9	-0.2	-0.2	-2.1	1.4	1.6	0.9	1.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.0	-0.3	-1.0	0.4	-0.6	0.1	0.2	-0.0	0.6	-0.8	0.5	0.8
Medication: Aspirin	0.7	0.9	3.2	-1.0	-1.8	-0.7	-1.1	-1.1	-0.8	-0.8	0.6	-0.3	0.2	1.1
Supplements: Vitamin C	0.3	0.3	0.9	-0.4	-1.0	0.2	-0.4	-0.8	0.5	-0.7	0.5	0.3	0.5	0.1
Knee pain experienced in last month	0.1	0.2	0.7	-0.4	0.1	0.8	-0.0	-0.2	-0.5	0.0	-0.7	0.8	-0.2	-0.1
Hypertension (Self-reported)	0.2	0.5	1.3	-0.3	-0.0	-1.0	0.9	0.4	1.1	1.0	-0.7	-0.1	0.0	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	11.5	-3.4	-1.0	-0.3	-0.8	-1.5	0.2	-1.5	-0.2	1.7	0.6	0.7
Illnesses of father: Heart disease	0.4	0.5	2.1	-0.0	0.1	-1.4	0.1	1.0	-0.2	0.8	0.5	-1.1	0.2	0.7
Illnesses of siblings: Diabetes	0.6	0.8	2.0	1.2	-0.1	-1.0	-0.9	0.6	1.0	0.1	1.4	0.1	1.1	0.8
Smoking status: Previous	3.2	4.8	8.4	2.4	2.1	1.9	2.4	1.8	-0.5	2.5	-1.9	-2.9	-2.8	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	3.5	-1.9	-0.5	-1.5	-0.8	0.3	0.1	0.3	0.6	-0.3	0.8	1.0
Whole body fat-free mass	0.4	2.5	9.1	-2.4	-2.0	-3.0	-1.6	-0.5	-1.1	-0.7	1.0	0.2	0.2	1.7
Leg fat-free mass (right)	0.7	3.7	10.2	-2.6	-2.5	-3.2	-2.2	-1.0	-1.2	-1.3	1.5	0.7	0.7	2.3
Arm fat percentage (left)	0.7	2.9	4.9	-2.1	-2.0	-2.2	-2.2	-1.6	-2.1	-0.7	1.2	0.8	0.1	2.1
Average weekly red wine intake	0.2	0.3	1.5	0.6	0.3	1.2	-0.2	0.4	0.8	0.0	0.4	-0.6	0.5	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.7	-0.2	-0.2	0.3	0.0	-0.3	-0.0	0.1	-0.3	-0.9	0.0	0.2
Mood swings	1.4	2.5	6.7	-2.6	-1.6	-2.1	-1.3	0.6	0.8	-1.0	1.7	1.7	1.4	1.6
Loneliness, isolation	3.1	4.3	7.0	-1.8	-2.4	-2.1	-2.5	-0.5	0.5	-1.9	2.3	2.6	2.3	2.5
Long-standing illness, disability or infirmity	0.7	1.1	3.0	-1.7	-1.3	-1.3	-1.0	-0.2	-0.2	-0.9	1.1	0.3	0.6	1.4
Ever had bowel cancer screening	0.6	0.8	2.7	-0.5	0.9	1.6	0.7	-0.1	0.2	-0.9	-0.8	0.8	-0.6	-1.3
Diabetes diagnosed by doctor	0.1	0.2	0.7	-0.4	0.1	-0.5	-0.5	0.1	0.0	0.0	0.8	0.1	0.5	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.8	-0.2	0.6	0.4	0.8	0.4	1.3	1.3	-0.6	-0.8	0.2	0.4
Friendships satisfaction	0.3	0.4	1.2	0.9	-0.2	-1.1	-0.5	0.7	-0.3	0.2	0.8	-0.8	0.6	0.2
Qualifications: nursing, teaching	0.6	0.9	2.4	-1.6	-0.8	-0.0	-1.1	-0.9	-1.0	-1.2	1.1	0.3	0.3	0.8
Commuting to job workplace: Walk	0.7	0.8	3.0	0.6	1.0	0.8	0.5	1.5	1.7	0.6	-0.6	0.1	0.8	-0.4
Eye problems/disorders: Cataract	1.1	1.2	3.5	1.3	0.9	0.9	1.2	0.8	1.9	0.9	-0.5	-1.6	-0.3	-0.8
Mouth/teeth dental problems: Mouth ulcers	1.0	1.7	4.3	0.7	2.1	1.7	1.3	1.4	-0.6	0.6	-0.8	-1.2	-1.0	-1.8
Medication for cholesterol	0.2	0.3	1.2	-0.1	-0.4	0.3	-0.5	0.9	-0.2	-1.1	0.7	0.7	0.4	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	7.9	0.6	2.8	0.5	2.3	1.9	0.8	2.5	-1.5	-1.7	-0.7	-1.7
Back pain experienced in last month	0.2	0.3	1.4	-0.5	-0.0	0.3	0.2	0.3	-0.8	0.1	-0.6	0.5	-1.2	-0.6
Mineral and other dietary supplements	0.4	0.6	1.8	-1.3	-0.2	-0.8	-0.2	-1.0	-1.2	-0.1	0.7	0.6	-0.9	0.1
Breast cancer (self-reported)	0.5	0.6	2.2	-0.1	-0.6	-0.3	-1.0	0.2	0.0	-0.2	1.4	-0.8	0.8	1.5
Asthma (self-reported)	3.1	6.1	14.0	3.1	2.7	2.0	2.7	1.9	1.2	3.2	-2.4	-3.7	-1.0	-1.8
Osteoporosis (self-reported)	0.1	0.2	0.7	0.8	0.1	-0.6	0.1	-0.2	0.7	0.3	-0.1	-0.4	0.2	0.2
Osteoarthritis (self-reported)	0.6	0.8	2.2	0.0	1.1	1.5	0.8	0.9	0.1	0.9	-1.2	-0.3	-0.4	-1.2
Medication: Aspirin	0.3	0.4	1.7	-0.9	-1.3	-0.7	-0.6	0.0	-0.2	-0.1	0.4	-0.7	0.3	0.9
Medication: Gliclazide	1.0	1.1	5.4	2.3	0.8	0.3	0.1	0.5	1.5	1.4	-0.1	-0.9	0.9	0.0
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	0.0	-0.9	0.7	-0.1	-0.8	0.9	-1.1	-1.1	0.6	0.4	-0.3
Smoking status: Current	0.8	1.2	4.1	1.1	0.9	-0.3	0.8	1.8	2.0	1.0	-0.4	-0.4	0.6	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	5.0	0.7	-0.7	-2.2	-0.9	-0.8	-1.1	-0.7	1.1	-0.3	0.4	0.5
Whole body water mass	0.5	2.6	9.2	-2.4	-2.1	-3.0	-1.6	-0.5	-1.2	-0.7	1.1	0.2	0.2	1.8
Leg predicted mass (right)	0.6	3.4	9.4	-2.5	-2.4	-3.1	-2.1	-1.0	-1.2	-1.1	1.4	0.6	0.7	2.2
Arm fat mass (left)	0.8	3.2	7.0	-2.5	-2.1	-2.6	-2.3	-1.2	-1.9	-0.6	1.3	0.7	0.2	2.2
Number of self-reported non-cancer illnesses	0.6	1.1	2.7	0.0	1.5	-0.0	1.6	0.4	0.3	0.8	-1.4	-1.3	-0.7	-1.4
Average weekly champagne plus white wine intake	0.5	0.7	1.9	1.3	0.7	1.4	0.7	0.5	1.1	-0.3	-0.9	0.4	0.6	-0.9
Miserableness	1.6	2.9	6.0	-2.5	-1.8	-2.3	-1.5	0.4	0.1	-2.2	1.9	1.6	1.2	1.5
Guilty feelings	0.1	0.2	1.2	-1.1	0.2	-0.1	0.3	0.4	-0.1	-0.5	0.1	0.4	0.0	-0.4
Wears glasses or contact lenses	0.3	0.3	1.3	-0.0	-0.7	0.3	-0.1	-0.3	-0.7	-1.1	-0.1	-0.4	-0.9	-0.3
Ever taken oral contraceptive pill	0.6	0.7	1.4	1.1	-1.0	-0.3	-1.0	-0.9	-0.9	0.1	0.8	-0.7	-0.1	1.2
Hearing aid user	1.1	1.3	2.8	0.8	1.0	0.4	1.6	-0.0	-1.7	0.4	-1.1	-0.6	-1.5	-1.6
Mother’s age at death	0.5	0.7	2.2	-1.5	-0.7	-1.1	-0.7	0.7	-0.1	-0.7	0.8	0.8	0.4	0.7
Financial situation satisfaction	0.3	0.4	1.1	-0.3	0.8	-0.6	0.5	1.0	-0.7	0.1	-0.3	-0.6	-0.1	-0.9
Tinnitus: Yes, now most or all of the time	0.9	1.1	5.2	1.2	0.4	0.5	0.5	0.1	-2.3	-0.7	0.4	0.9	-1.3	-1.1
Commuting to job workplace: Public transport	1.0	1.2	3.8	-0.1	1.6	1.0	1.4	1.1	1.2	1.9	-0.6	-0.9	0.1	-0.8
Eye problems/disorders: Glaucoma	1.5	1.8	5.0	-2.2	-1.6	-1.5	-1.3	-1.2	-0.6	-1.2	1.3	0.9	0.5	1.4
Medication: Blood pressure	1.0	1.9	5.8	0.4	1.6	0.8	1.8	0.2	1.5	2.4	-1.8	-1.2	-0.6	-1.2
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.0	-0.7	0.7	1.7	0.7	-0.4	-0.4	1.1	-1.3	-0.9	-1.0	-1.0
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.5	-0.1	-1.1	0.2	-0.9	0.4	1.4	-0.9	0.5	0.1	1.9	1.3
High cholesterol (Self-reported)	1.1	2.0	4.5	1.1	1.5	0.5	2.1	1.0	0.9	2.0	-1.6	-1.4	-1.3	-1.3
Medication: Bendroflumethiazide	0.3	0.4	2.1	-0.7	0.4	1.5	0.2	-1.0	0.1	0.2	-0.1	-0.1	-0.2	-0.8
Medication: Paracetamol	0.7	1.1	4.7	-2.2	-0.8	-0.9	-1.2	-0.3	0.2	-0.5	1.0	1.0	1.2	1.0
Medication: Lisinopril	0.3	0.4	1.5	0.9	0.3	0.3	0.7	0.1	0.1	1.1	-0.0	-1.2	-0.5	-0.4
Medication: Atorvastatin	1.8	2.2	4.0	1.6	2.0	1.2	1.9	-0.4	-0.7	1.7	-1.9	-1.0	-1.7	-1.4
Illnesses of father: High blood pressure	0.4	0.5	2.8	0.8	0.6	-1.7	0.1	0.7	-0.6	0.2	0.9	-0.4	0.0	0.3
Alcohol drinker status: Never	1.2	1.4	5.3	-1.3	-1.0	-1.3	-0.9	0.9	0.6	-1.0	0.5	2.3	1.1	1.1
Ever smoked	1.8	3.2	6.2	2.5	1.5	1.5	1.8	2.0	1.0	2.0	-1.3	-2.4	-1.2	-1.9
Basal metabolic rate	0.5	2.7	9.0	-2.5	-2.1	-3.0	-1.8	-0.7	-1.3	-0.6	1.0	0.3	0.3	1.9
Leg fat percentage (left)	0.2	0.9	2.1	-1.4	-0.9	-0.8	-1.3	-1.0	-0.7	0.2	0.3	0.8	0.1	1.4
Arm fat-free mass (left)	0.5	2.3	7.8	-2.4	-1.9	-2.8	-1.6	-0.2	-0.8	-0.4	1.1	0.4	0.4	1.8
Number of operations (self-reported)	0.5	0.8	2.5	-0.0	0.3	-1.2	0.3	-0.2	-1.6	0.9	-0.3	-1.5	-1.2	-0.3
Average weekly beer plus cider intake	1.3	1.9	4.7	1.2	2.0	0.4	1.4	0.1	-0.6	2.0	-1.3	-1.0	-2.2	-1.0
Irritability	0.6	1.1	6.0	-2.5	-1.0	-1.3	-0.3	0.7	0.9	-0.1	0.4	0.1	0.9	0.9
Risk taking	0.4	0.6	1.6	1.0	-0.5	0.4	-0.8	0.6	1.3	0.4	1.2	-0.2	0.6	0.7
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.8	1.1	0.6	1.3	0.9	1.2	0.3	-0.1	-0.2	0.5	-0.3	-1.0
Fractured/broken bones in last 5 years	1.3	1.6	3.4	1.5	1.7	1.3	1.8	-0.2	-0.3	0.2	-1.8	-0.2	-1.2	-1.8
Age started oral contraceptive pill	0.2	0.3	1.7	0.3	-0.1	-1.3	0.2	0.7	-0.6	0.4	0.2	-0.6	-0.2	0.2
Diastolic blood pressure, automated reading	0.6	1.7	4.7	-1.6	-1.5	-2.2	-0.9	-1.4	-1.1	-1.2	0.8	1.2	-0.1	1.5
Ever depressed for a whole week	1.7	2.1	6.6	-1.1	-1.1	-2.6	-0.8	-1.7	-2.3	-0.9	1.3	0.7	-1.2	0.6
Unable to work because of sickness or disability	0.4	0.5	1.6	-0.2	-1.2	0.3	-0.7	-1.3	-0.5	-0.2	0.6	-0.0	-0.3	0.9
Commuting to job workplace: Cycle	2.2	2.7	6.0	1.4	1.9	1.7	2.4	0.6	-0.2	1.6	-1.9	-1.4	-1.5	-2.2
Myopia	0.5	0.7	1.9	-0.5	-0.2	-0.0	-1.2	-0.2	1.0	-0.2	1.4	0.5	1.4	0.9
Vascular/heart problems diagnosed by doctor	0.2	0.5	2.0	0.6	0.8	1.4	0.0	-0.3	-1.0	-0.3	-0.1	-0.4	-0.3	-0.9
Cholesterol lowering medication	1.3	2.0	4.2	0.4	1.5	0.4	1.8	2.0	1.7	2.0	-1.2	-1.5	-0.5	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	4.1	-2.0	-0.7	-0.8	-0.2	0.8	0.4	0.1	-0.6	0.3	0.7	0.7
Pain experienced in last month	0.5	0.9	3.7	1.9	0.9	0.7	0.9	0.8	0.0	0.6	-0.3	-1.5	-0.2	-0.7
Supplements: Calcium	0.4	0.5	1.6	-1.0	-0.3	-0.2	-0.2	-0.8	-0.7	-1.3	-0.1	0.6	-0.2	-0.8
Basal cell carcinoma (self-reported)	0.6	0.7	3.6	-0.3	-0.3	-1.1	0.0	0.9	1.9	0.1	-0.3	0.1	0.9	0.8
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.2	-1.3	-0.5	-0.8	-0.1	-0.7	-1.5	-0.8	0.2	-0.2	-0.7	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.8	-0.2	-0.8	-1.3	-0.7	-0.2	-1.1	-0.6	0.4	0.7	0.0	0.4
Heart disease (siblings)	2.1	2.6	5.2	0.9	1.6	0.7	1.9	2.3	-1.0	1.5	-1.3	-1.5	-2.0	-2.1
Alcohol drinker status: Previous	0.9	1.0	3.4	0.3	1.1	1.9	1.0	0.4	-0.6	1.0	-0.8	-0.7	-1.3	-0.9
Pack years of smoking	2.2	3.2	5.1	-2.1	-2.1	-2.3	-1.8	0.0	1.3	-1.6	1.5	2.1	1.9	1.8
Impedance of whole body	0.8	4.2	16.0	0.9	2.5	4.0	2.5	0.9	1.5	1.6	-2.4	-0.7	-0.4	-2.1
Leg fat mass (left)	0.5	2.0	5.2	-2.3	-1.6	-1.8	-1.8	-1.1	-1.2	-0.3	0.7	0.7	0.3	1.9
Arm predicted mass (left)	0.3	1.7	6.4	-2.2	-1.5	-2.5	-1.2	0.2	-0.7	-0.1	0.7	0.1	0.3	1.5