Hub : Genes

GPR132

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0950 0.0340 5.3e-04 0.001 NA 0.046 NA 0.000 2.7e-01 NA 1.2e-04 NA 3.2e-01
2 GTEx Heart Left Ventricle 0.1007 0.0442 6.0e-03 0.025 NA 0.001 NA 0.008 1.6e-02 NA 2.8e-01 NA 1.1e-01
3 GTEx Lung 0.1063 0.0439 3.0e-03 0.024 NA 0.035 NA 0.051 6.1e-03 NA 1.1e-03 NA 9.0e-05
4 GTEx Nerve Tibial 0.1026 0.0386 8.1e-04 0.117 NA 0.061 NA 0.089 1.3e-08 NA 3.8e-05 NA 7.2e-07
5 GTEx Skin Not Sun Exposed Suprapubic 0.2070 0.0600 2.3e-04 -0.001 NA 0.028 NA 0.009 3.5e-01 NA 1.1e-02 NA 1.0e-01
6 GTEx Skin Sun Exposed Lower leg 0.1540 0.0450 8.7e-06 0.091 NA 0.094 NA 0.095 5.4e-08 NA 3.6e-08 NA 2.9e-08
7 GTEx Stomach 0.1230 0.0490 2.2e-03 -0.006 NA -0.006 NA -0.006 9.9e-01 NA 1.0e+00 NA 8.5e-01
8 GTEx Thyroid 0.1030 0.0350 7.0e-05 0.133 NA 0.120 NA 0.132 2.2e-10 NA 2.0e-09 NA 2.9e-10
9 YFS Blood 0.0128 0.0063 8.4e-03 0.003 0.007 0.000 0.007 0.002 3.5e-02 1.4e-03 2.9e-01 0.0015 5.8e-02
10 TCGA Bladder Urothelial Carcinoma 0.0330 0.0220 4.8e-03 0.029 0.022 0.005 NA 0.015 1.7e-03 5.6e-03 1.2e-01 NA 1.8e-02
11 TCGA Thyroid Carcinoma 0.0830 0.0410 2.2e-06 0.052 0.072 0.060 NA 0.056 8.6e-06 1.6e-07 1.8e-06 NA 3.9e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 1.3 2.0 5.4 -2.2 -0.9 0.0 -1.6 0.9 0.9 -1.8 0.9 2.3 1.5 0.8
Bipolar Disorder or Schizophrenia 0.3 0.8 3.1 -1.8 -0.3 0.0 -0.4 1.3 0.5 -1.2 0.0 1.4 0.3 -0.2
Depressed Affect (Nagel 2018) 3.2 6.8 13.5 -3.7 -3.0 -3.5 -2.6 -0.3 -0.2 -2.3 3.1 2.8 1.7 2.8
Depression (Nagel 2018) 4.2 6.3 10.5 -3.1 -2.5 -3.1 -2.8 -0.2 0.0 -2.5 3.2 2.5 2.5 2.4
Intelligence (Savage-Jansen 2018) 0.6 1.8 3.9 -1.8 -1.7 0.4 -1.6 -2.0 -1.3 -1.9 0.6 1.2 0.2 0.7
Neuroticism (Nagel 2018) 1.2 2.8 10.1 -3.2 -1.9 -2.3 -1.3 0.1 -0.5 -1.2 1.5 1.7 1.0 1.6
Schizophrenia (2018) 0.2 0.4 0.9 -0.6 0.3 0.0 0.7 0.9 -0.0 -0.1 -0.7 -0.1 -0.9 -1.0
Schizophrenia vs Biploar Disorder 0.2 0.3 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -1.7 -0.8
Worry (Nagel 2018) 0.4 0.8 4.2 -2.1 -1.1 -1.2 -0.4 -0.2 -0.6 -0.1 0.2 0.4 -0.1 1.0
Alzheimer’s Disease (in mother) 0.7 0.8 2.0 -0.2 0.1 -0.6 -1.0 1.2 0.0 -1.4 0.9 1.3 1.3 0.3
Alzheimer’s Disease (in father) 0.3 0.3 0.8 -0.8 -0.2 0.0 -0.4 0.9 0.0 -0.7 0.2 0.9 0.3 0.1
Alzheimer’s Disease (including proxy) 1.9 2.7 5.4 -1.3 -1.1 -1.1 -2.2 0.8 0.1 -2.3 1.9 2.3 2.1 1.4
Crohns Disease (2017) 1.3 2.9 8.4 -0.3 -1.9 -0.6 -2.4 -1.4 0.8 -2.1 2.9 1.0 1.7 1.6
Irritable Bowel Disease (IBD) 3.7 8.8 21.0 -2.0 -3.0 -1.8 -4.2 -1.0 1.1 -3.7 4.6 2.3 3.5 3.0
Ulcerative Colitis (UC) 3.8 7.1 13.3 -2.7 -2.6 -1.8 -3.6 -0.3 0.9 -3.2 3.6 2.3 3.1 2.8
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.2 0.3 1.2 -0.9 -0.6 -0.0 -0.3 -0.1 -0.1 -1.1 0.1 -0.4 0.7 -0.2
Verbal and Numeric Reasoning (VNR) 1.5 3.7 11.5 -3.4 -2.0 -0.1 -1.9 -2.5 -1.3 -2.4 0.9 2.4 0.6 1.1
Breast Cancer 0.2 0.5 3.5 1.9 -0.1 -0.4 0.0 -0.8 0.8 -0.3 -0.1 -0.0 0.4 0.0
Ovarian Cancer 0.2 0.3 1.4 0.7 0.3 -1.2 0.1 -0.2 -0.6 0.6 0.4 -0.3 0.0 0.2
Prostate Cancer 0.3 0.5 1.3 0.3 0.6 -1.1 0.7 0.7 -0.1 1.1 0.7 -0.4 -0.6 0.2
Age at First Birth 0.1 0.2 0.8 -0.8 0.1 0.3 0.1 0.9 0.1 0.4 -0.2 -0.0 -0.3 -0.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.5 2.0 7.9 0.7 0.6 0.0 0.6 -2.4 -2.8 -0.6 -0.3 0.2 -2.1 -1.5
Coronary Artery Disease (CAD) 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -0.4 -0.6
Crohns Disease (2012) 0.7 1.1 4.2 -0.2 -1.2 0.0 -1.7 -0.3 -0.1 -0.8 2.0 -0.3 0.9 1.3
Mean Putamen Volume 3.1 3.6 10.9 -3.3 -2.3 0.0 -2.4 -0.8 -0.8 -2.1 1.4 1.9 1.3 2.1
Fasting Glucose 0.8 1.0 3.0 -0.3 0.0 0.7 1.7 1.2 1.3 -0.7 1.4 0.7 1.2 0.4
HbA1C 0.3 0.3 1.3 1.0 -0.3 0.2 0.0 -0.7 1.1 -0.1 0.1 -0.3 0.5 0.6
HDL Cholesterol 0.6 1.0 4.0 -0.3 1.2 0.0 1.0 -0.7 -0.9 0.6 -1.2 0.2 -2.0 -1.1
LDL Cholesterol 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 -0.5 0.1
Lupus 3.0 4.6 10.0 2.5 2.2 -0.6 2.3 1.9 -0.9 3.2 -1.1 -2.8 -2.5 -1.9
Neuroticism (2016) 2.0 2.9 8.9 -3.0 -2.0 -0.9 -1.6 -1.4 -0.7 -2.2 1.5 1.8 1.2 1.2
Primary Biliary Cirrhosis 1.6 2.2 5.9 1.2 2.4 -0.3 2.0 1.2 -0.7 1.9 -0.8 -0.3 -2.1 -1.6
Rheumatoid Arthritis 0.4 0.5 2.2 -0.6 1.0 0.0 0.5 1.5 -0.3 1.0 0.4 -0.5 -0.2 -0.2
Schizophrenia (2014) 0.3 0.7 2.4 -0.4 0.7 0.0 1.0 1.5 0.2 0.5 -0.5 -0.9 -1.2 -0.9
Triglycerides 0.1 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -0.5 0.6 -0.7
Type 2 Diabetes (T2D) (2012) 0.2 0.3 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -1.0 -1.4
Ulcerative Colitis 4.0 5.7 11.8 -2.6 -2.3 0.0 -3.2 -0.7 -0.2 -3.4 3.4 2.6 2.3 2.2
Blood Eosinophil Count 0.2 1.6 4.8 0.1 -2.2 -0.8 -1.8 -1.3 0.2 -0.9 1.4 0.4 1.5 1.7
Blood Platelet Count 1.4 15.8 50.8 -3.9 -3.3 -1.7 -4.2 5.5 4.7 1.5 2.7 -0.1 7.1 3.9
Blood Red Count 0.3 2.6 14.8 -0.1 0.3 0.0 0.3 3.9 1.1 3.0 -0.2 -1.5 1.2 -0.2
Blood White Count 0.4 3.1 7.8 -1.0 -2.8 -1.1 -2.7 -0.3 0.5 -0.9 1.7 0.7 2.7 2.2
Heel T-Score 0.2 1.8 8.9 -3.0 -0.4 -1.5 -0.5 1.5 2.2 0.2 0.5 0.4 0.8 0.8
BMI 0.6 3.2 9.6 -1.2 -2.1 -3.1 -2.2 -1.0 -1.5 -0.5 2.3 -0.1 0.6 2.4
Height 0.1 2.6 22.8 -4.8 -0.4 -0.3 0.5 0.3 -0.5 -0.0 -2.0 0.6 -0.2 -0.2
Waist Hip Ratio (WHR) 0.5 2.2 4.5 -0.2 -1.8 -1.2 -1.7 0.9 1.9 -0.3 1.8 0.5 2.1 2.1
Systolic Blood Pressure 0.2 1.0 3.8 -2.0 -0.4 -1.4 -0.1 0.1 1.2 -0.5 -0.1 1.3 0.9 0.5
Smoking Status 1.7 4.0 7.7 2.8 2.2 0.8 1.9 2.5 1.4 2.6 -0.9 -2.6 -1.2 -1.7
Allergy or Eczema 1.6 4.1 9.7 1.1 2.3 0.3 2.9 1.4 0.1 2.4 -2.4 -3.1 -1.5 -2.2
Cardiovascular Disease 0.3 0.9 5.1 0.2 0.2 -2.3 0.8 0.4 1.6 1.2 -0.3 0.1 -0.0 0.1
Hypothyroidism (self reported) 1.7 3.9 12.5 3.5 1.8 -0.3 2.5 -0.3 -1.2 1.6 -1.6 -2.7 -2.0 -1.5
Respiratory disease 2.7 6.0 13.7 3.2 2.8 2.0 2.8 1.3 0.5 2.7 -2.4 -3.7 -1.6 -2.2
Type 2 Diabetes (T2D) (2018) 0.5 1.0 5.1 -0.0 -0.2 -2.3 -0.7 0.0 -0.4 0.8 1.5 -0.7 0.5 1.1
Lung FEV1/FVC ratio 0.3 1.7 5.1 0.1 -1.7 -1.8 -1.4 -2.3 -1.0 -1.1 1.2 0.4 0.2 1.3
Lung FVC 0.6 3.2 16.9 4.1 1.7 0.4 1.9 0.4 -0.4 -0.3 -1.6 -1.5 -1.0 -2.3
Neuroticism 0.9 2.2 9.1 -3.0 -1.7 -2.2 -1.1 -0.6 0.1 -0.7 1.2 1.0 0.4 1.5
Chronotype (morning person) 1.7 3.8 13.1 3.6 1.4 2.9 1.6 -0.7 -1.1 0.9 -1.7 -2.5 -1.3 -1.7
Hair Pigment 0.0 1.2 4.3 2.1 1.6 -0.3 1.1 0.9 -0.5 0.6 -0.5 -0.4 -1.3 -1.4
Tanning 0.6 7.2 22.0 0.4 2.2 1.9 3.1 -0.1 -3.5 2.3 -2.9 -2.4 -4.7 -2.7
Hand grip strength (left) 0.5 1.4 8.6 2.9 1.5 -0.4 1.0 0.3 0.3 0.5 -0.8 -1.2 -0.6 -0.9
Number of treatments/medications taken 0.3 0.6 2.2 -1.5 -0.3 -1.0 0.0 0.3 0.1 1.0 -0.4 -1.3 -0.2 0.5
Average weekly spirits intake 1.0 1.2 7.6 0.5 -1.3 -2.7 -0.7 -0.1 0.9 -0.8 1.1 0.2 0.6 0.8
Sensitivity / hurt feelings 0.3 0.6 1.1 0.4 0.2 0.3 0.9 -0.9 -1.0 0.9 -0.5 -1.0 -1.0 -0.7
Frequency of depressed mood in last 2 weeks 1.7 2.4 10.7 -3.3 -0.9 -1.6 -1.1 0.7 0.3 -1.8 1.2 1.7 1.5 0.3
Hearing difficulty/problems: Yes 4.1 6.3 14.5 2.6 3.1 2.3 3.0 1.4 -0.7 1.9 -3.2 -1.3 -2.3 -3.8
Relative age of first facial hair 0.3 0.7 2.0 1.1 0.6 0.8 0.8 -0.1 -0.7 -0.6 -1.4 -0.2 -0.5 -1.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.3 1.1 -0.4 -0.4 0.9 -0.4 -1.0 -0.0 0.0 -0.2 -1.1 0.2 0.6
Ever used hormone-replacement therapy (HRT) 0.5 0.7 4.1 -0.4 -0.2 -2.0 -0.6 -0.7 -1.0 -0.3 1.1 0.2 -0.1 0.0
Ever had hysterectomy (womb removed) 1.0 1.1 4.1 -0.6 -0.6 -1.3 -1.3 0.4 -1.6 -0.2 2.0 -0.1 -0.5 0.9
Systolic blood pressure, automated reading 0.4 1.0 2.8 -1.7 -1.2 -1.6 -0.5 0.9 0.7 -0.6 0.5 0.7 1.0 1.1
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.6 0.1 -0.4 -0.1 0.1 0.1 -0.8 0.1 -0.1 -0.4 -0.2 -0.0
Angina 0.5 0.7 2.8 -0.6 -0.6 0.4 -0.1 -1.4 -1.4 0.3 -0.0 -0.2 -1.7 -0.1
Medication for hormone replacement therapy 0.2 0.2 0.8 0.2 -0.4 -0.6 -0.7 -0.9 -0.4 0.1 0.1 -0.1 -0.1 0.7
Vitamin and mineral supplements 1.0 1.4 6.7 -0.7 -0.3 -1.7 -0.1 -1.0 -2.6 -1.2 0.2 0.9 -1.4 -0.1
Supplements: Zinc 0.4 0.4 1.1 -0.4 0.4 1.0 0.6 -0.3 0.7 0.6 -0.6 -0.9 0.1 -0.6
Medication: Co-codamol 0.3 0.3 1.5 -1.2 -0.0 -0.4 -0.3 0.6 -0.3 0.9 0.2 -0.2 -0.2 0.5
Medication: Metformin 0.4 0.6 2.4 0.4 0.8 -0.1 0.2 1.3 0.3 1.5 -0.1 -1.2 0.1 -0.0
Diabetes (father) 1.0 1.2 2.9 0.7 -0.2 -1.4 -0.5 0.8 1.0 1.2 1.4 -1.7 1.0 1.3
Diabetes (mother) 1.6 2.1 4.5 -0.8 -1.6 -1.8 -1.4 1.1 1.6 0.2 1.3 0.1 2.1 2.0
Severe depression (siblings) 0.6 0.7 1.4 -0.7 -0.7 -1.2 -0.8 1.2 0.7 -0.3 1.0 0.3 0.5 1.0
Pack years adult smoking proportion 2.7 4.1 6.9 -2.3 -2.2 -2.6 -2.1 0.2 1.6 -1.6 1.7 2.3 2.3 2.1
Impedance of leg (right) 1.2 6.0 17.0 1.6 3.1 4.1 3.1 0.9 1.5 2.4 -2.9 -1.2 -1.1 -2.6
Leg fat-free mass (left) 0.7 3.8 11.5 -2.6 -2.5 -3.4 -2.1 -1.2 -1.6 -1.0 1.5 0.4 0.4 2.4
Trunk fat percentage 0.3 1.2 4.9 -2.2 -1.3 -0.8 -1.2 -1.0 -1.4 -0.1 -0.0 0.6 -0.0 1.3
Hand grip strength (right) 0.5 1.2 7.2 2.7 1.5 -0.4 0.8 1.0 0.5 0.3 -0.6 -0.8 -0.1 -1.0
Townsend deprivation index at recruitment 0.6 0.9 2.6 0.5 1.0 1.6 1.0 -1.2 0.5 -0.0 -0.8 0.5 -1.0 -1.1
Current tobacco smoking 0.8 1.2 6.5 0.8 0.5 -0.6 0.5 1.8 2.6 0.8 0.0 -0.2 1.2 -0.7
Average weekly fortified wine intake 0.8 0.9 1.8 -0.4 -0.9 -0.7 -1.3 0.8 1.3 -0.5 1.3 0.2 1.3 1.0
Maternal smoking around birth 0.8 1.2 2.5 1.5 1.2 0.9 1.1 0.6 -0.9 1.6 -0.8 -1.0 -0.9 -1.2
Fed-up feelings 2.9 5.2 14.3 -3.8 -2.5 -3.1 -2.2 -1.0 -0.5 -2.3 2.4 2.2 1.3 2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 3.5 4.6 11.5 -1.9 -1.9 -3.4 -2.2 0.9 1.3 -1.4 2.8 1.6 2.5 2.5
Relative age voice broke 0.8 1.2 7.4 2.7 0.6 0.7 1.1 0.6 0.8 -0.1 -1.0 0.3 0.0 -1.3
Taking other prescription medications 0.2 0.4 1.5 -1.1 0.0 -1.2 0.1 0.7 -0.1 0.1 -0.4 -0.5 0.2 0.6
Age when periods started (menarche) 0.3 0.8 2.5 0.3 1.6 0.7 1.3 0.4 0.3 1.2 -0.9 -1.0 -0.4 -0.4
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 2.5 0.4 -0.1 -1.4 -0.1 0.2 -1.6 0.1 1.0 -1.1 -0.6 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.0 -0.6 -0.0 0.3 -0.0 -1.0 -0.6 1.0 -0.9 0.2 -1.0 -0.0
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 3.6 1.8 1.9 0.4 1.4 1.7 1.0 1.2 -1.0 -1.3 -0.2 -1.5
Qualifications: CSEs or equivalent 0.2 0.3 1.4 -0.1 0.0 -0.9 -0.2 -1.2 0.5 0.3 0.5 -0.6 0.1 0.5
Serious illness, injury or assault to yourself 0.2 0.2 1.6 -1.2 0.1 -0.7 -0.1 -0.1 0.1 0.3 0.1 -0.1 0.3 0.3
High blood pressure 0.2 0.6 2.1 -0.3 -0.1 -1.4 0.6 1.0 1.4 1.0 -0.5 -0.0 0.4 0.6
Hayfever, allergic rhinitis or eczema 0.6 1.4 3.7 0.1 1.7 0.1 1.9 1.0 0.6 1.3 -1.2 -1.1 -0.5 -1.5
Multivitamins +/- minerals 0.4 0.5 2.1 0.3 -0.2 1.5 -0.3 0.1 1.3 0.4 0.2 -0.4 1.1 0.3
Stomach or abdominal pain in last month 3.2 4.0 8.9 -1.0 -0.9 -2.6 -1.6 1.7 3.0 -0.3 2.4 2.0 2.7 2.1
Supplements: Glucosamine 0.3 0.4 2.5 1.6 -0.0 0.3 -0.1 -0.0 -0.8 -0.8 -0.4 -0.0 -0.1 -0.4
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.9 -0.4 1.2 -0.9 1.0 1.0 -0.4 0.9 -0.7 -0.9 -1.4 -0.6
Medication: Atenolol 0.4 0.5 2.0 -1.4 0.0 -0.1 0.2 -1.0 -0.7 -0.6 -0.3 0.2 -0.7 -0.7
Medication: Levothyroxine sodium 0.4 0.7 2.2 1.4 0.6 -0.9 1.0 -0.2 0.2 1.0 -0.5 -1.5 -0.5 -0.2
Sitting height 0.3 2.1 7.8 -2.8 -2.5 -1.1 -1.6 -1.0 -0.5 -0.7 0.6 0.9 0.7 1.6
Chronic bronchitis/emphysema (father) 1.3 1.5 5.4 -0.5 1.2 -0.2 1.0 -1.3 -2.3 0.7 -0.6 -0.3 -2.2 -0.9
High blood pressure (mother) 0.4 0.6 2.3 -1.5 0.3 -1.4 0.6 1.2 0.1 -0.1 -0.3 -0.0 -0.0 0.3
Body mass index (BMI) 0.8 3.5 9.4 -1.6 -2.2 -3.1 -2.3 -1.6 -2.2 -0.8 1.5 0.9 -0.0 2.2
Impedance of leg (left) 1.3 6.4 20.7 1.4 3.2 4.6 3.0 1.2 2.1 2.1 -3.0 -0.8 -0.6 -2.8
Leg predicted mass (left) 0.7 3.8 11.2 -2.6 -2.5 -3.4 -2.2 -1.2 -1.6 -1.1 1.5 0.4 0.4 2.4
Trunk fat mass 0.5 2.1 6.9 -2.6 -1.8 -1.6 -1.7 -1.1 -1.6 -0.5 0.4 0.7 0.2 1.7
Waist circumference 1.2 4.3 8.1 -2.6 -2.9 -2.6 -2.8 -1.1 -1.1 -1.1 2.0 1.0 1.2 2.8
Number of incorrect matches in round 2.0 3.4 8.6 2.9 2.0 1.5 2.4 1.6 0.1 1.9 -1.8 -0.8 -1.5 -2.1
Past tobacco smoking 2.4 4.4 8.2 -2.6 -2.0 -1.9 -2.1 -1.8 0.1 -2.5 1.5 2.9 2.4 2.0
Alcohol usually taken with meals 0.3 0.4 1.5 1.2 0.6 0.2 -0.1 0.5 0.8 -0.3 0.5 -0.1 1.2 -0.6
Nervous feelings 0.2 0.4 1.8 -1.3 -0.8 -0.9 -0.0 0.2 0.9 0.3 0.1 -0.1 0.7 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.2 0.8 -0.8 0.6 -0.9 -0.1 0.2 -0.6 -0.1 0.4 -0.4 -0.1 -0.4
Hearing difficulty/problems with background noise 0.4 0.6 2.3 -0.2 0.4 0.2 1.1 0.9 -0.8 0.6 -1.5 0.1 -0.8 -0.9
Hair/balding pattern: Pattern 2 2.9 3.6 6.6 -2.1 -2.0 -1.9 -2.0 -2.6 -1.4 -1.9 2.1 1.9 0.7 1.8
Had menopause 0.6 0.8 2.8 -1.0 -0.5 -1.7 -0.7 1.3 0.1 -0.4 0.9 0.4 0.9 0.7
Had other major operations 0.2 0.3 1.5 -1.2 -0.7 0.2 -0.6 -0.3 0.2 -0.5 0.0 0.4 0.4 -0.2
Forced vital capacity (FVC) 0.1 0.3 0.6 0.4 0.0 -0.8 0.3 -0.7 -0.6 -0.7 -0.7 -0.3 -0.1 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 2.4 -0.9 0.1 0.4 0.4 0.0 0.1 1.5 -1.3 0.1 -0.8 -0.1
Ever unenthusiastic/disinterested for a whole week 2.1 2.5 11.6 -2.5 -1.5 -3.4 -0.7 -0.8 -1.2 -1.1 1.5 0.7 0.1 1.0
Qualifications: None of the above 0.5 1.1 4.1 0.0 -1.4 -0.9 -1.0 -0.5 -0.3 -1.4 0.9 2.0 0.2 1.1
Financial difficulties in last 2 years 0.5 0.7 3.8 1.9 0.6 -0.9 0.4 -1.3 0.6 -0.0 -0.2 -0.4 -0.1 -0.1
Mouth/teeth dental problems 0.8 1.2 4.1 -0.5 -1.7 -0.1 -1.4 -2.0 -0.8 -0.5 0.8 0.2 0.1 1.5
Heart attack 0.5 0.6 2.2 -1.0 -0.7 -0.9 -0.3 -0.9 -1.5 -1.0 0.4 0.1 -0.6 0.1
Allergy 0.9 2.1 4.7 -0.9 -2.0 -0.0 -2.2 -1.4 -1.0 -2.1 1.4 1.7 0.5 1.4
Pain all over the body in last month 1.3 1.4 5.1 0.0 -1.0 -2.3 -1.2 -0.2 0.1 -0.4 1.7 -0.3 0.9 1.9
Diabetes (self-reported) 0.1 0.2 0.5 -0.7 0.2 -0.1 -0.2 -0.0 -0.4 0.6 0.7 -0.5 -0.1 0.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.3 1.2 -0.7 0.6 0.3 0.8 -0.1 1.1 0.5 -0.3 0.1 0.4 -0.7
Medication: Ramipril 0.1 0.1 0.9 -1.0 0.1 -0.2 0.3 0.1 0.6 0.2 -0.3 -0.1 0.2 0.2
Medication: Simvastatin 0.8 1.1 4.1 -0.3 -0.1 -0.6 0.9 -0.2 -1.5 1.1 -0.4 -1.6 -2.0 -0.4
Fluid intelligence score 0.2 0.5 3.4 -1.8 -0.7 -0.1 -0.5 -0.7 -0.2 -0.6 -0.2 0.1 0.5 0.2
Illnesses of siblings 0.2 0.3 2.4 0.3 -0.0 0.2 0.0 -1.6 -0.0 0.1 -0.2 -0.0 -0.4 0.6
Neuroticism score 0.6 1.2 6.6 -2.6 -1.3 -1.6 -0.5 -0.3 -0.1 -0.5 0.7 0.5 0.4 1.0
Weight 0.8 4.0 8.9 -3.0 -2.6 -2.8 -2.4 -1.6 -1.8 -1.0 1.2 0.8 0.4 2.4
Impedance of arm (right) 0.3 1.2 6.4 -0.0 1.2 2.5 1.3 0.2 1.0 0.4 -1.2 -0.2 0.4 -1.0
Arm fat percentage (right) 0.8 3.0 5.2 -2.1 -2.1 -2.1 -2.2 -1.7 -2.3 -0.9 1.1 0.9 -0.0 2.0
Trunk fat-free mass 0.4 2.0 7.2 -2.2 -1.9 -2.7 -1.4 -0.3 -0.9 -0.7 0.8 0.2 0.1 1.5
Hip circumference 0.8 3.5 7.1 -2.7 -2.4 -2.0 -2.4 -1.2 -1.7 -1.3 1.2 1.3 0.8 2.3
Time employed in main current job 1.1 1.3 5.1 -0.7 2.3 0.4 1.7 0.6 0.5 0.0 -0.9 0.2 -0.6 -2.0
Alcohol intake versus 10 years previously 1.2 1.8 3.5 -0.1 -1.6 -1.8 -1.8 -1.3 -1.2 -1.0 1.9 0.4 0.7 1.4
Father’s age at death 0.5 0.6 2.0 0.7 -0.6 0.3 -1.2 -0.2 -0.1 -1.4 1.3 -0.2 0.5 0.5
Worrier / anxious feelings 0.1 0.2 0.9 -0.7 -0.4 -0.8 0.1 0.2 -0.5 0.5 0.1 -0.9 -0.2 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 4.7 -2.2 -0.4 -2.1 -0.7 1.1 0.9 -0.3 0.9 0.4 1.1 1.2
Falls in the last year 0.3 0.4 2.5 -0.1 -0.1 -0.3 0.1 0.9 1.6 0.5 -0.5 0.4 0.6 0.1
Hair/balding pattern: Pattern 3 1.5 2.2 4.4 1.1 2.1 1.0 2.0 1.6 0.9 1.3 -1.5 -1.7 -0.6 -1.7
Number of live births 0.1 0.2 1.0 0.8 0.1 -1.0 0.5 0.2 -0.3 -0.2 -0.1 0.2 -0.3 -0.4
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 2.9 0.2 -0.7 -1.6 -0.6 -1.7 -1.1 -1.4 0.2 0.2 0.1 0.2
Pulse rate 1.0 1.6 4.6 -0.7 -1.5 -1.2 -1.7 0.9 0.1 -0.2 2.1 -0.0 0.9 2.1
Happiness 0.5 0.6 2.2 -0.0 0.7 -0.2 0.7 1.2 0.2 0.9 -0.8 -1.5 -0.3 -1.0
Noisy workplace 0.7 0.8 4.6 -0.2 -0.6 -2.1 0.3 1.6 0.8 -0.0 -0.0 0.7 0.6 0.4
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.9 -0.3 -0.7 0.3 -1.2 -0.5 -0.6 -1.0 0.5 1.4 0.5 0.9
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 4.1 -0.3 1.4 -1.4 0.6 2.0 1.6 1.1 -0.2 -0.1 0.8 -0.4
Mouth/teeth dental problems: Dentures 0.9 1.6 3.5 -0.2 1.4 -0.3 1.9 1.3 0.2 1.4 -1.2 -1.1 -1.7 -1.6
Asthma 2.4 4.8 11.8 2.9 2.4 1.7 2.5 1.5 1.1 2.8 -1.9 -3.4 -0.7 -1.6
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 3.4 -1.8 -0.3 0.5 -0.7 -0.6 0.2 0.3 0.1 0.1 -0.1 0.3
Medication: Cholesterol lowering 1.1 1.7 10.1 -0.3 -0.6 -0.5 0.2 -1.8 -3.2 -0.2 0.0 -0.3 -2.2 -0.0
Depression (self-reported) 0.9 1.0 4.7 -1.2 -0.9 -2.2 -0.9 -0.0 -0.7 -1.2 0.9 0.9 0.4 0.4
Medication: Lansoprazole 0.9 1.0 3.9 -0.6 -0.5 0.3 -0.2 -2.0 1.4 -1.4 -0.6 1.3 0.9 -0.3
Prospective memory result 0.5 0.7 4.0 1.1 -0.5 -0.5 -0.4 0.2 2.0 0.1 0.3 0.3 1.0 0.6
Lung cancer (father) 2.4 2.9 9.1 -3.0 -2.2 -1.9 -1.6 -1.2 -0.7 -0.6 1.9 1.5 0.2 1.7
Illnesses of mother 1.1 1.3 7.1 2.7 1.1 0.5 0.6 -1.1 0.4 1.1 -1.0 -0.9 -0.8 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 2.9 0.6 -1.0 -1.4 -0.9 -1.7 -0.8 -1.6 0.6 0.0 0.3 0.4
Pulse wave Arterial Stiffness index 0.2 0.2 1.1 -1.1 -0.4 0.2 0.1 0.3 -0.2 0.6 -0.0 -0.1 0.1 0.4
Impedance of arm (left) 0.3 1.4 6.6 -0.0 1.4 2.6 1.4 0.4 0.8 0.7 -1.3 -0.6 -0.0 -1.1
Arm fat mass (right) 1.0 4.3 8.5 -2.8 -2.4 -2.9 -2.5 -1.5 -2.1 -1.1 1.6 1.2 0.4 2.4
Trunk predicted mass 0.3 1.8 7.0 -2.1 -1.8 -2.6 -1.3 -0.3 -1.0 -0.5 0.8 0.0 0.0 1.4
Standing height 0.1 1.2 10.3 -3.2 -1.0 -0.1 -0.2 0.0 0.4 -0.4 -0.7 0.1 0.7 0.5
Length of working week for main job 0.3 0.4 1.6 0.5 0.7 -1.3 0.2 0.3 0.9 0.4 0.4 0.0 0.5 0.4
Exposure to tobacco smoke at home 0.5 0.5 2.0 0.2 -0.3 -0.5 -0.1 1.1 1.4 0.1 -0.1 0.4 1.4 0.5
Breastfed as a baby 0.7 0.8 2.7 -0.5 0.1 1.6 -0.2 0.5 1.3 -0.5 -0.3 1.4 1.2 -0.6
Tense / ‘highly strung’ 1.6 2.7 4.9 -0.4 1.7 1.5 2.2 0.4 -1.3 1.6 -1.7 -1.8 -2.2 -2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 4.7 -1.5 -0.3 -2.2 0.0 -0.2 -1.6 -0.8 0.7 0.1 -0.6 0.0
Hair/balding pattern: Pattern 4 2.8 6.7 9.7 2.8 2.9 3.1 2.5 0.6 -1.0 2.9 -2.9 -3.1 -2.8 -2.4
Birth weight of first child 2.0 3.6 6.9 1.0 1.6 2.2 1.6 0.3 -1.7 1.8 -2.6 -2.6 -2.4 -1.9
Peak expiratory flow (PEF) 0.7 1.5 6.1 0.3 -0.8 -0.8 -1.1 -2.5 -1.7 -2.1 0.4 0.7 -0.1 0.1
Pulse wave reflection index 0.5 0.6 2.6 -0.0 0.2 0.5 1.1 0.2 -0.1 0.4 -1.6 -0.3 -0.9 -1.0
Ever highly irritable/argumentative for 2 days 1.4 1.7 4.9 -0.7 -2.2 -0.6 -1.3 -1.3 -0.5 -1.6 0.7 2.2 0.2 1.0
Loud music exposure frequency 0.7 0.8 2.2 -0.2 0.7 -0.1 1.2 0.5 -1.5 0.5 -0.8 -0.6 -1.4 -1.1
Qualifications: O levels/GCSEs or equivalent 1.5 2.5 4.9 -2.2 -2.0 -1.3 -1.7 -1.2 -0.0 -2.1 1.1 1.7 1.3 1.4
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.7 0.5 -0.5 -0.7 -0.8 0.0 -0.6 -1.2 0.5 1.3 0.7 0.5
Blood clot in the leg (DVT) 1.0 1.2 3.1 -0.7 -1.5 -1.8 -1.3 -0.7 -1.1 -1.1 0.9 1.1 0.4 1.1
Medication: Paracetamol 0.5 0.9 3.1 -1.8 -0.4 -0.9 -1.0 0.1 0.3 -0.5 1.1 0.7 1.4 0.9
Headache pain in last month 2.2 3.8 7.7 -2.8 -1.8 -1.9 -2.5 -0.3 0.2 -1.9 2.2 1.9 1.8 2.3
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 4.6 0.3 0.1 0.4 -0.8 0.9 2.1 0.2 0.7 0.0 1.7 0.6
Glaucoma (self-reported) 0.6 0.7 2.5 -1.6 -0.5 -0.6 -0.5 -1.3 -1.0 -1.0 0.5 0.6 -0.3 0.1
Gout (self-reported) 1.1 1.5 4.8 0.1 -1.3 -0.6 -1.3 -2.2 -0.6 -1.8 0.9 1.1 0.5 1.2
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 4.5 2.1 0.9 -0.8 1.4 -0.5 -1.1 0.8 -0.5 -1.7 -1.3 -0.5
Medication: Amlodipine 1.0 1.4 3.2 1.2 1.6 0.7 1.7 -0.5 -0.1 1.0 -1.3 -0.7 -1.1 -1.8
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.1 0.7 0.9 0.6 0.5 1.4 1.3 1.4 -0.1 -1.2 0.1 -0.1
Birth weight 0.9 2.0 4.5 1.2 1.8 1.4 2.1 0.7 -0.4 0.9 -1.2 -1.0 -1.5 -2.1
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.9 -1.0 -1.0 0.3 -0.6 -0.8 -0.6 0.5 1.3 -0.3 0.3 1.4
High blood pressure (siblings) 1.2 1.7 6.1 -2.2 -1.1 -0.3 -0.9 1.0 0.5 -1.6 0.5 2.5 1.4 0.3
Forced vital capacity (FVC), Best measure 0.2 0.6 2.5 0.0 -1.0 -0.8 -0.7 -0.6 -0.2 -1.6 0.5 0.3 0.8 0.2
Body fat percentage 0.3 1.4 4.2 -2.0 -1.3 -0.9 -1.3 -1.4 -1.5 -0.2 0.1 0.7 -0.1 1.3
Leg fat percentage (right) 0.3 1.0 2.2 -1.4 -1.0 -1.1 -1.3 -1.3 -1.1 0.4 0.3 0.5 -0.2 1.5
Arm fat-free mass (right) 0.3 1.6 7.4 -1.9 -1.5 -2.7 -1.2 -0.0 -0.6 -0.0 0.7 -0.1 0.2 1.5
Exposure to tobacco smoke outside home 0.4 0.5 1.1 0.7 -0.7 -0.8 -0.4 0.7 0.9 0.1 0.9 0.3 1.1 0.9
Comparative body size at age 10 0.6 1.7 4.7 0.4 -1.9 -2.2 -1.5 -1.0 -0.7 -0.9 1.2 0.3 0.7 1.9
Number of full brothers 2.3 2.9 7.2 2.1 2.0 0.8 1.6 -0.5 -1.9 0.5 -1.7 -0.1 -2.7 -2.4
Worry too long after embarrassment 0.3 0.5 1.8 -0.6 0.5 0.7 1.4 0.4 0.4 0.7 -1.1 -0.3 -0.4 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.1 6.3 -2.5 -2.0 -2.0 -1.5 -0.9 -0.3 -0.5 1.5 0.6 0.4 1.7
Wheeze or whistling in the chest in last year 1.6 2.8 9.0 -0.1 1.3 1.1 1.1 3.0 1.9 2.7 -1.1 -2.3 0.3 -0.2
Number of children fathered 1.4 1.6 6.3 -1.8 -0.9 -2.5 -0.9 1.2 -0.1 -0.1 1.8 -0.5 0.3 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.8 -0.6 -1.0 -0.9 -1.0 -0.6 0.0 -0.5 1.4 0.2 0.9 1.3
Age at first live birth 0.5 0.9 3.6 0.4 -1.0 -0.2 -0.6 0.5 1.4 -0.1 0.7 0.4 1.9 1.5
Pulse wave peak to peak time 0.1 0.2 0.7 0.8 0.4 -0.0 -0.2 -0.5 0.1 -0.7 0.1 0.1 -0.0 -0.4
Health satisfaction 1.1 1.5 4.3 -2.1 -1.3 -2.0 -0.9 1.2 -0.5 -0.5 1.0 0.8 0.7 1.1
Shortness of breath walking on level ground 0.3 0.3 1.1 0.4 -0.2 -0.3 -0.3 -0.3 0.8 -0.8 0.6 1.0 0.8 -0.0
Qualifications: College or University degree 0.4 1.2 2.8 -0.9 -1.3 0.3 -1.7 0.3 0.4 -1.1 1.4 1.0 1.4 1.2
Eye problems/disorders: None of the above 0.4 0.5 3.2 -0.0 0.6 -0.4 -0.4 0.2 -0.4 -0.9 0.1 1.8 0.5 -0.3
Mouth/teeth dental problems: Loose teeth 0.5 0.5 3.2 -0.7 -0.9 -1.8 -0.1 -0.2 -0.3 -0.6 0.5 0.4 -0.4 0.5
Emphysema/chronic bronchitis 0.6 0.7 3.8 -0.2 0.0 -0.8 0.0 1.7 1.9 0.1 -0.2 0.2 0.9 0.1
Medication for pain relief, constipation, heartburn 0.9 1.5 8.2 2.9 1.3 1.1 1.0 -0.0 -0.4 0.4 -0.4 -0.7 -1.3 -1.2
Neck or shoulder pain in last month 0.4 0.6 1.3 -0.3 -0.3 0.9 -1.0 0.3 1.2 -0.2 0.8 1.1 1.1 0.6
Medication: Blood pressure 0.5 0.9 4.7 -0.8 -0.2 -1.1 0.7 -0.5 -2.2 -0.4 -0.4 0.1 -1.3 -0.3
Angina (self-reported) 0.5 0.7 2.8 -0.6 -0.7 0.3 -0.2 -1.4 -1.3 0.4 0.1 -0.4 -1.7 0.0
Migraine (self-reported) 0.5 0.6 3.7 -0.6 0.6 -0.2 0.6 1.9 1.0 0.4 -0.5 0.3 0.5 -0.3
Medication: Ibuprofen 0.5 0.6 3.9 -2.0 -0.7 0.4 -0.6 -1.2 0.1 -0.2 0.1 0.2 -0.4 0.1
Medication: Allopurinol 1.0 1.4 2.5 -0.8 -1.4 -0.7 -1.6 -1.2 -1.3 -1.5 0.8 1.2 0.5 1.4
Medication: Omeprazole 1.1 1.3 8.2 -2.9 -1.4 -0.7 -1.0 -0.2 -0.1 -0.6 -0.4 0.9 0.6 1.1
Medication: Seretide 50 evohaler 0.5 0.6 1.9 0.4 -0.7 0.7 -0.7 -1.1 -0.7 -1.4 0.5 0.8 0.6 0.3
Mean time to correctly identify matches 0.4 0.7 2.1 -1.3 -1.5 0.0 -0.8 -0.2 0.2 -1.3 0.5 0.1 1.0 0.5
Heart disease (mother) 0.4 0.4 2.4 -1.5 -0.2 -0.3 0.3 1.1 -0.6 -0.2 0.2 -0.7 -0.2 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 2.7 1.0 1.1 1.5 0.6 0.0 -0.3 0.2 -1.4 -0.1 -0.4 -1.6
Whole body fat mass 0.5 2.2 5.9 -2.4 -1.8 -1.7 -1.8 -1.2 -1.4 -0.7 0.5 0.8 0.3 1.8
Leg fat mass (right) 0.5 1.9 4.4 -2.1 -1.5 -1.9 -1.6 -1.3 -1.5 -0.1 0.6 0.5 -0.1 1.8
Arm predicted mass (right) 0.3 1.5 7.4 -2.0 -1.4 -2.7 -1.1 -0.0 -0.6 -0.1 0.7 0.0 0.2 1.3
Pulse rate, automated reading 0.2 0.7 2.8 0.2 -1.1 -0.5 -0.8 0.4 -0.1 0.4 1.5 -0.8 0.1 1.7
Alcohol intake frequency. 1.1 2.6 6.8 -2.3 -1.8 -1.5 -1.7 -0.2 -0.9 -1.6 1.5 2.6 0.8 1.5
Comparative height size at age 10 0.4 2.3 9.0 -3.0 -1.8 -0.6 -1.6 -1.1 -1.0 -1.1 1.0 1.2 0.5 1.9
Number of full sisters 0.3 0.4 1.7 1.1 0.5 0.1 0.2 0.4 1.3 0.7 -0.1 -0.6 0.3 0.3
Suffer from ‘nerves’ 0.3 0.4 1.7 -1.2 -0.9 -1.3 0.0 0.3 0.2 -0.1 -0.1 0.5 0.2 0.5
Overall health rating 0.3 0.7 4.9 -1.0 -0.0 -2.2 0.1 0.6 -0.7 -0.3 0.5 -0.4 -0.3 0.1
Chest pain or discomfort 1.4 2.1 4.8 -1.8 -1.9 -1.4 -1.6 -0.7 0.6 -0.3 1.9 0.7 1.1 2.2
Had major operations 0.8 0.9 2.5 0.2 0.4 -0.1 1.0 -0.4 -1.6 0.6 -1.4 -1.5 -1.1 -0.8
Age at last live birth 0.5 0.7 4.1 0.4 0.1 -0.2 0.2 0.5 2.0 0.2 -0.2 1.0 1.5 0.4
Family relationship satisfaction 0.9 1.2 3.1 -1.1 -1.1 -1.8 -1.3 0.6 0.2 -0.6 1.1 0.2 1.5 1.1
Leg pain on walking 0.5 0.6 2.5 -0.9 -0.8 -1.6 -0.0 0.6 -0.3 -0.6 -0.4 1.2 0.1 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.8 1.4 1.0 -0.3 0.5 -0.5 -0.7 0.9 -0.2 -1.1 -1.0 -0.4
Commuting to job workplace: Car/motor vehicle 2.0 2.3 4.9 -1.0 -2.2 -2.0 -1.9 -0.2 -0.2 -2.1 1.4 1.6 0.9 1.4
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 1.0 -0.3 -1.0 0.4 -0.6 0.1 0.2 -0.0 0.6 -0.8 0.5 0.8
Medication: Aspirin 0.7 0.9 3.2 -1.0 -1.8 -0.7 -1.1 -1.1 -0.8 -0.8 0.6 -0.3 0.2 1.1
Supplements: Vitamin C 0.3 0.3 0.9 -0.4 -1.0 0.2 -0.4 -0.8 0.5 -0.7 0.5 0.3 0.5 0.1
Knee pain experienced in last month 0.1 0.2 0.7 -0.4 0.1 0.8 -0.0 -0.2 -0.5 0.0 -0.7 0.8 -0.2 -0.1
Hypertension (Self-reported) 0.2 0.5 1.3 -0.3 -0.0 -1.0 0.9 0.4 1.1 1.0 -0.7 -0.1 0.0 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 11.5 -3.4 -1.0 -0.3 -0.8 -1.5 0.2 -1.5 -0.2 1.7 0.6 0.7
Illnesses of father: Heart disease 0.4 0.5 2.1 -0.0 0.1 -1.4 0.1 1.0 -0.2 0.8 0.5 -1.1 0.2 0.7
Illnesses of siblings: Diabetes 0.6 0.8 2.0 1.2 -0.1 -1.0 -0.9 0.6 1.0 0.1 1.4 0.1 1.1 0.8
Smoking status: Previous 3.2 4.8 8.4 2.4 2.1 1.9 2.4 1.8 -0.5 2.5 -1.9 -2.9 -2.8 -2.0
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 3.5 -1.9 -0.5 -1.5 -0.8 0.3 0.1 0.3 0.6 -0.3 0.8 1.0
Whole body fat-free mass 0.4 2.5 9.1 -2.4 -2.0 -3.0 -1.6 -0.5 -1.1 -0.7 1.0 0.2 0.2 1.7
Leg fat-free mass (right) 0.7 3.7 10.2 -2.6 -2.5 -3.2 -2.2 -1.0 -1.2 -1.3 1.5 0.7 0.7 2.3
Arm fat percentage (left) 0.7 2.9 4.9 -2.1 -2.0 -2.2 -2.2 -1.6 -2.1 -0.7 1.2 0.8 0.1 2.1
Average weekly red wine intake 0.2 0.3 1.5 0.6 0.3 1.2 -0.2 0.4 0.8 0.0 0.4 -0.6 0.5 -0.2
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.7 -0.2 -0.2 0.3 0.0 -0.3 -0.0 0.1 -0.3 -0.9 0.0 0.2
Mood swings 1.4 2.5 6.7 -2.6 -1.6 -2.1 -1.3 0.6 0.8 -1.0 1.7 1.7 1.4 1.6
Loneliness, isolation 3.1 4.3 7.0 -1.8 -2.4 -2.1 -2.5 -0.5 0.5 -1.9 2.3 2.6 2.3 2.5
Long-standing illness, disability or infirmity 0.7 1.1 3.0 -1.7 -1.3 -1.3 -1.0 -0.2 -0.2 -0.9 1.1 0.3 0.6 1.4
Ever had bowel cancer screening 0.6 0.8 2.7 -0.5 0.9 1.6 0.7 -0.1 0.2 -0.9 -0.8 0.8 -0.6 -1.3
Diabetes diagnosed by doctor 0.1 0.2 0.7 -0.4 0.1 -0.5 -0.5 0.1 0.0 0.0 0.8 0.1 0.5 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.8 -0.2 0.6 0.4 0.8 0.4 1.3 1.3 -0.6 -0.8 0.2 0.4
Friendships satisfaction 0.3 0.4 1.2 0.9 -0.2 -1.1 -0.5 0.7 -0.3 0.2 0.8 -0.8 0.6 0.2
Qualifications: nursing, teaching 0.6 0.9 2.4 -1.6 -0.8 -0.0 -1.1 -0.9 -1.0 -1.2 1.1 0.3 0.3 0.8
Commuting to job workplace: Walk 0.7 0.8 3.0 0.6 1.0 0.8 0.5 1.5 1.7 0.6 -0.6 0.1 0.8 -0.4
Eye problems/disorders: Cataract 1.1 1.2 3.5 1.3 0.9 0.9 1.2 0.8 1.9 0.9 -0.5 -1.6 -0.3 -0.8
Mouth/teeth dental problems: Mouth ulcers 1.0 1.7 4.3 0.7 2.1 1.7 1.3 1.4 -0.6 0.6 -0.8 -1.2 -1.0 -1.8
Medication for cholesterol 0.2 0.3 1.2 -0.1 -0.4 0.3 -0.5 0.9 -0.2 -1.1 0.7 0.7 0.4 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.5 2.9 7.9 0.6 2.8 0.5 2.3 1.9 0.8 2.5 -1.5 -1.7 -0.7 -1.7
Back pain experienced in last month 0.2 0.3 1.4 -0.5 -0.0 0.3 0.2 0.3 -0.8 0.1 -0.6 0.5 -1.2 -0.6
Mineral and other dietary supplements 0.4 0.6 1.8 -1.3 -0.2 -0.8 -0.2 -1.0 -1.2 -0.1 0.7 0.6 -0.9 0.1
Breast cancer (self-reported) 0.5 0.6 2.2 -0.1 -0.6 -0.3 -1.0 0.2 0.0 -0.2 1.4 -0.8 0.8 1.5
Asthma (self-reported) 3.1 6.1 14.0 3.1 2.7 2.0 2.7 1.9 1.2 3.2 -2.4 -3.7 -1.0 -1.8
Osteoporosis (self-reported) 0.1 0.2 0.7 0.8 0.1 -0.6 0.1 -0.2 0.7 0.3 -0.1 -0.4 0.2 0.2
Osteoarthritis (self-reported) 0.6 0.8 2.2 0.0 1.1 1.5 0.8 0.9 0.1 0.9 -1.2 -0.3 -0.4 -1.2
Medication: Aspirin 0.3 0.4 1.7 -0.9 -1.3 -0.7 -0.6 0.0 -0.2 -0.1 0.4 -0.7 0.3 0.9
Medication: Gliclazide 1.0 1.1 5.4 2.3 0.8 0.3 0.1 0.5 1.5 1.4 -0.1 -0.9 0.9 0.0
Illnesses of father: None of the above (group 1) 0.4 0.5 1.2 0.0 -0.9 0.7 -0.1 -0.8 0.9 -1.1 -1.1 0.6 0.4 -0.3
Smoking status: Current 0.8 1.2 4.1 1.1 0.9 -0.3 0.8 1.8 2.0 1.0 -0.4 -0.4 0.6 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 5.0 0.7 -0.7 -2.2 -0.9 -0.8 -1.1 -0.7 1.1 -0.3 0.4 0.5
Whole body water mass 0.5 2.6 9.2 -2.4 -2.1 -3.0 -1.6 -0.5 -1.2 -0.7 1.1 0.2 0.2 1.8
Leg predicted mass (right) 0.6 3.4 9.4 -2.5 -2.4 -3.1 -2.1 -1.0 -1.2 -1.1 1.4 0.6 0.7 2.2
Arm fat mass (left) 0.8 3.2 7.0 -2.5 -2.1 -2.6 -2.3 -1.2 -1.9 -0.6 1.3 0.7 0.2 2.2
Number of self-reported non-cancer illnesses 0.6 1.1 2.7 0.0 1.5 -0.0 1.6 0.4 0.3 0.8 -1.4 -1.3 -0.7 -1.4
Average weekly champagne plus white wine intake 0.5 0.7 1.9 1.3 0.7 1.4 0.7 0.5 1.1 -0.3 -0.9 0.4 0.6 -0.9
Miserableness 1.6 2.9 6.0 -2.5 -1.8 -2.3 -1.5 0.4 0.1 -2.2 1.9 1.6 1.2 1.5
Guilty feelings 0.1 0.2 1.2 -1.1 0.2 -0.1 0.3 0.4 -0.1 -0.5 0.1 0.4 0.0 -0.4
Wears glasses or contact lenses 0.3 0.3 1.3 -0.0 -0.7 0.3 -0.1 -0.3 -0.7 -1.1 -0.1 -0.4 -0.9 -0.3
Ever taken oral contraceptive pill 0.6 0.7 1.4 1.1 -1.0 -0.3 -1.0 -0.9 -0.9 0.1 0.8 -0.7 -0.1 1.2
Hearing aid user 1.1 1.3 2.8 0.8 1.0 0.4 1.6 -0.0 -1.7 0.4 -1.1 -0.6 -1.5 -1.6
Mother’s age at death 0.5 0.7 2.2 -1.5 -0.7 -1.1 -0.7 0.7 -0.1 -0.7 0.8 0.8 0.4 0.7
Financial situation satisfaction 0.3 0.4 1.1 -0.3 0.8 -0.6 0.5 1.0 -0.7 0.1 -0.3 -0.6 -0.1 -0.9
Tinnitus: Yes, now most or all of the time 0.9 1.1 5.2 1.2 0.4 0.5 0.5 0.1 -2.3 -0.7 0.4 0.9 -1.3 -1.1
Commuting to job workplace: Public transport 1.0 1.2 3.8 -0.1 1.6 1.0 1.4 1.1 1.2 1.9 -0.6 -0.9 0.1 -0.8
Eye problems/disorders: Glaucoma 1.5 1.8 5.0 -2.2 -1.6 -1.5 -1.3 -1.2 -0.6 -1.2 1.3 0.9 0.5 1.4
Medication: Blood pressure 1.0 1.9 5.8 0.4 1.6 0.8 1.8 0.2 1.5 2.4 -1.8 -1.2 -0.6 -1.2
Pain type(s) experienced in last month: Hip pain 0.8 1.0 3.0 -0.7 0.7 1.7 0.7 -0.4 -0.4 1.1 -1.3 -0.9 -1.0 -1.0
Supplements: Fish oil (including cod liver oil) 0.7 0.9 3.5 -0.1 -1.1 0.2 -0.9 0.4 1.4 -0.9 0.5 0.1 1.9 1.3
High cholesterol (Self-reported) 1.1 2.0 4.5 1.1 1.5 0.5 2.1 1.0 0.9 2.0 -1.6 -1.4 -1.3 -1.3
Medication: Bendroflumethiazide 0.3 0.4 2.1 -0.7 0.4 1.5 0.2 -1.0 0.1 0.2 -0.1 -0.1 -0.2 -0.8
Medication: Paracetamol 0.7 1.1 4.7 -2.2 -0.8 -0.9 -1.2 -0.3 0.2 -0.5 1.0 1.0 1.2 1.0
Medication: Lisinopril 0.3 0.4 1.5 0.9 0.3 0.3 0.7 0.1 0.1 1.1 -0.0 -1.2 -0.5 -0.4
Medication: Atorvastatin 1.8 2.2 4.0 1.6 2.0 1.2 1.9 -0.4 -0.7 1.7 -1.9 -1.0 -1.7 -1.4
Illnesses of father: High blood pressure 0.4 0.5 2.8 0.8 0.6 -1.7 0.1 0.7 -0.6 0.2 0.9 -0.4 0.0 0.3
Alcohol drinker status: Never 1.2 1.4 5.3 -1.3 -1.0 -1.3 -0.9 0.9 0.6 -1.0 0.5 2.3 1.1 1.1
Ever smoked 1.8 3.2 6.2 2.5 1.5 1.5 1.8 2.0 1.0 2.0 -1.3 -2.4 -1.2 -1.9
Basal metabolic rate 0.5 2.7 9.0 -2.5 -2.1 -3.0 -1.8 -0.7 -1.3 -0.6 1.0 0.3 0.3 1.9
Leg fat percentage (left) 0.2 0.9 2.1 -1.4 -0.9 -0.8 -1.3 -1.0 -0.7 0.2 0.3 0.8 0.1 1.4
Arm fat-free mass (left) 0.5 2.3 7.8 -2.4 -1.9 -2.8 -1.6 -0.2 -0.8 -0.4 1.1 0.4 0.4 1.8
Number of operations (self-reported) 0.5 0.8 2.5 -0.0 0.3 -1.2 0.3 -0.2 -1.6 0.9 -0.3 -1.5 -1.2 -0.3
Average weekly beer plus cider intake 1.3 1.9 4.7 1.2 2.0 0.4 1.4 0.1 -0.6 2.0 -1.3 -1.0 -2.2 -1.0
Irritability 0.6 1.1 6.0 -2.5 -1.0 -1.3 -0.3 0.7 0.9 -0.1 0.4 0.1 0.9 0.9
Risk taking 0.4 0.6 1.6 1.0 -0.5 0.4 -0.8 0.6 1.3 0.4 1.2 -0.2 0.6 0.7
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.8 1.1 0.6 1.3 0.9 1.2 0.3 -0.1 -0.2 0.5 -0.3 -1.0
Fractured/broken bones in last 5 years 1.3 1.6 3.4 1.5 1.7 1.3 1.8 -0.2 -0.3 0.2 -1.8 -0.2 -1.2 -1.8
Age started oral contraceptive pill 0.2 0.3 1.7 0.3 -0.1 -1.3 0.2 0.7 -0.6 0.4 0.2 -0.6 -0.2 0.2
Diastolic blood pressure, automated reading 0.6 1.7 4.7 -1.6 -1.5 -2.2 -0.9 -1.4 -1.1 -1.2 0.8 1.2 -0.1 1.5
Ever depressed for a whole week 1.7 2.1 6.6 -1.1 -1.1 -2.6 -0.8 -1.7 -2.3 -0.9 1.3 0.7 -1.2 0.6
Unable to work because of sickness or disability 0.4 0.5 1.6 -0.2 -1.2 0.3 -0.7 -1.3 -0.5 -0.2 0.6 -0.0 -0.3 0.9
Commuting to job workplace: Cycle 2.2 2.7 6.0 1.4 1.9 1.7 2.4 0.6 -0.2 1.6 -1.9 -1.4 -1.5 -2.2
Myopia 0.5 0.7 1.9 -0.5 -0.2 -0.0 -1.2 -0.2 1.0 -0.2 1.4 0.5 1.4 0.9
Vascular/heart problems diagnosed by doctor 0.2 0.5 2.0 0.6 0.8 1.4 0.0 -0.3 -1.0 -0.3 -0.1 -0.4 -0.3 -0.9
Cholesterol lowering medication 1.3 2.0 4.2 0.4 1.5 0.4 1.8 2.0 1.7 2.0 -1.2 -1.5 -0.5 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 4.1 -2.0 -0.7 -0.8 -0.2 0.8 0.4 0.1 -0.6 0.3 0.7 0.7
Pain experienced in last month 0.5 0.9 3.7 1.9 0.9 0.7 0.9 0.8 0.0 0.6 -0.3 -1.5 -0.2 -0.7
Supplements: Calcium 0.4 0.5 1.6 -1.0 -0.3 -0.2 -0.2 -0.8 -0.7 -1.3 -0.1 0.6 -0.2 -0.8
Basal cell carcinoma (self-reported) 0.6 0.7 3.6 -0.3 -0.3 -1.1 0.0 0.9 1.9 0.1 -0.3 0.1 0.9 0.8
Heart attack/myocardial infarction (self-reported) 0.5 0.6 2.2 -1.3 -0.5 -0.8 -0.1 -0.7 -1.5 -0.8 0.2 -0.2 -0.7 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.8 -0.2 -0.8 -1.3 -0.7 -0.2 -1.1 -0.6 0.4 0.7 0.0 0.4
Heart disease (siblings) 2.1 2.6 5.2 0.9 1.6 0.7 1.9 2.3 -1.0 1.5 -1.3 -1.5 -2.0 -2.1
Alcohol drinker status: Previous 0.9 1.0 3.4 0.3 1.1 1.9 1.0 0.4 -0.6 1.0 -0.8 -0.7 -1.3 -0.9
Pack years of smoking 2.2 3.2 5.1 -2.1 -2.1 -2.3 -1.8 0.0 1.3 -1.6 1.5 2.1 1.9 1.8
Impedance of whole body 0.8 4.2 16.0 0.9 2.5 4.0 2.5 0.9 1.5 1.6 -2.4 -0.7 -0.4 -2.1
Leg fat mass (left) 0.5 2.0 5.2 -2.3 -1.6 -1.8 -1.8 -1.1 -1.2 -0.3 0.7 0.7 0.3 1.9
Arm predicted mass (left) 0.3 1.7 6.4 -2.2 -1.5 -2.5 -1.2 0.2 -0.7 -0.1 0.7 0.1 0.3 1.5