TWAS hub - GPR157

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.156	0.0455	2.9e-04	0.064	NA	0.075	NA	0.072	8.8e-06	NA	1.6e-06	NA	2.6e-06
2	GTEx	Cells Transformed fibroblasts	0.153	0.0480	9.9e-04	0.049	NA	0.102	NA	0.085	1.4e-04	NA	4.7e-08	NA	6.2e-07
3	GTEx	Esophagus Mucosa	0.180	0.0580	5.5e-04	0.083	NA	0.063	NA	0.090	3.3e-06	NA	4.9e-05	NA	1.3e-06
4	GTEx	Muscle Skeletal	0.199	0.0438	6.9e-07	0.063	NA	0.083	NA	0.091	8.5e-07	NA	1.4e-08	NA	3.2e-09
5	GTEx	Skin Sun Exposed Lower leg	0.183	0.0530	2.4e-04	0.094	NA	0.077	NA	0.089	3.5e-08	NA	6.3e-07	NA	7.6e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Prostate Cancer	3.8	5.4	8.9	1.9	3.0	2.0	2.3	2.4
Eye problems/disorders: Cataract	3.8	4.5	8.1	-2.9	-1.7	-1.5	-2.5	-1.8
Lung FEV1/FVC ratio	3.7	18.7	34.0	1.6	1.1	5.7	4.9	5.8
Medication: Gliclazide	3.7	4.2	5.5	2.3	0.5	2.3	2.2	2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.6	4.3	6.3	0.9	2.0	2.0	2.5	2.5
Alcohol drinker status: Previous	3.5	4.0	8.2	-1.1	-1.6	-2.9	-1.7	-2.2
Alzheimer’s Disease (in mother)	3.4	4.0	10.8	-3.3	-0.7	-0.9	-2.3	-1.5
Chronic bronchitis/emphysema (father)	3.3	3.9	7.0	-2.0	-0.1	-1.4	-2.6	-2.6
Qualifications: O levels/GCSEs or equivalent	3.2	5.1	6.5	1.6	2.5	2.4	2.2	2.5
Age at First Birth	3.1	4.4	5.8	1.6	2.3	1.7	2.4	2.3
Noisy workplace	3.1	3.8	6.9	-2.6	-1.6	-1.6	-2.0	-1.6
Financial difficulties in last 2 years	3.0	4.1	7.3	1.7	2.7	2.1	1.7	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.5	6.6	0.9	1.7	2.6	1.6	2.2
Medication: Ibuprofen (e.g. Nurofen)	2.7	3.4	5.1	-1.5	-1.8	-2.3	-1.6	-1.9
Alzheimer’s Disease (including proxy)	2.6	3.8	10.6	-3.2	-0.6	-0.9	-2.2	-1.5
Had other major operations	2.5	3.1	5.4	0.1	2.1	2.3	1.5	1.8
Tense / ‘highly strung’	2.4	3.9	6.2	-0.9	-1.7	-2.3	-2.1	-2.5
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.5	6.9	-0.2	-0.6	-2.4	-2.2	-2.6
Eye problems/disorders: None of the above	2.3	2.6	2.9	1.7	1.6	1.6	1.7	1.4
Body Mass Index (BMI) (2010)	2.2	3.0	4.7	-1.5	-1.8	-1.2	-2.2	-1.8
Medication: Amlodipine	2.2	3.1	4.4	1.5	1.4	1.7	2.1	2.0
Migraine (self-reported)	2.2	2.7	3.5	-1.4	-1.6	-1.9	-1.8	-1.4
Hair/balding pattern: Pattern 2	2.1	2.7	8.2	-2.9	-1.5	-0.8	-1.3	-0.7
Headache pain in last month	2.1	3.6	9.7	-0.2	-1.2	-3.1	-1.4	-2.1
Diabetes (father)	1.9	2.3	6.4	0.8	2.5	0.8	1.3	1.5
Medication: Levothyroxine sodium	1.8	3.1	5.2	0.7	1.3	2.0	2.0	2.3
Mouth/teeth dental problems: Dentures	1.8	3.1	5.7	-1.0	-0.9	-2.0	-2.0	-2.4
Mouth/teeth dental problems: Loose teeth	1.8	2.1	2.9	1.4	1.4	1.4	1.3	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	3.2	-0.9	-1.7	-1.1	-1.7	-1.8
Average weekly red wine intake	1.8	2.7	3.5	1.8	1.5	1.9	1.5	1.6
Illnesses of father: High blood pressure	1.8	2.3	5.3	1.8	2.3	1.3	0.9	0.6
Irritability	1.8	3.0	4.7	-1.6	-0.5	-1.9	-2.2	-2.0
Ulcerative Colitis	1.7	2.4	3.5	-0.1	1.8	1.9	1.3	1.9
Hearing difficulty/problems with background noise	1.7	2.7	7.1	-1.0	-0.4	-2.7	-1.4	-1.9
Hair/balding pattern: Pattern 4	1.7	4.2	7.7	2.8	-0.4	2.3	2.0	2.0
Commuting to job workplace: Cycle	1.7	2.0	3.6	0.8	0.7	1.9	1.4	1.9
Heart disease (siblings)	1.7	2.1	3.3	-1.8	-0.5	-1.0	-1.8	-1.7
Number of incorrect matches in round	1.6	2.7	4.5	-1.5	-0.0	-1.9	-1.8	-2.1
Mineral and other dietary supplements	1.6	2.1	4.2	-0.0	-2.0	-1.4	-1.1	-1.7
Qualifications: None of the above	1.5	3.1	7.3	0.7	-1.7	-2.7	-1.2	-1.9
Ovarian Cancer	1.4	1.9	4.0	-0.5	-2.0	-1.2	-1.4	-1.3
Hypothyroidism (self reported)	1.4	3.2	4.5	1.7	1.0	1.9	2.1	2.0
Breastfed as a baby	1.4	1.7	2.5	1.5	1.6	0.5	1.3	1.2
Medication: Aspirin	1.4	1.8	5.8	-0.1	2.4	0.9	1.2	1.1
Blood White Count	1.3	10.0	19.0	2.1	0.4	3.4	4.4	3.8
Hearing difficulty/problems: Yes	1.3	2.0	3.7	-0.9	-1.2	-1.9	-1.2	-1.6
Systolic blood pressure, automated reading	1.3	3.7	4.6	1.6	1.9	2.0	1.9	2.1
Alcohol usually taken with meals	1.3	2.2	2.6	1.6	1.0	1.6	1.6	1.5
Illnesses of siblings	1.3	1.8	3.0	1.1	1.2	1.2	1.7	1.3
Qualifications: A levels/AS levels or equivalent	1.3	2.9	5.3	0.2	1.9	2.3	1.5	1.8
Medication: Lansoprazole	1.3	1.5	2.8	-1.1	0.1	-1.7	-1.4	-1.4
Medication: Allopurinol	1.3	1.8	2.7	1.6	-0.1	1.3	1.4	1.6
Medication: Atorvastatin	1.3	1.6	2.8	1.4	1.1	0.5	1.7	1.4
Medication for hormone replacement therapy	1.2	1.3	2.0	0.5	1.0	1.4	1.4	1.2
Happiness	1.2	1.5	2.9	-0.7	-1.7	-1.3	-1.0	-1.1
Prospective memory result	1.2	1.5	2.7	-0.1	-1.3	-1.4	-1.1	-1.7
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	3.8	1.4	0.8	1.5	1.8	1.9
Number of full brothers	1.2	1.5	3.0	1.7	0.0	0.6	1.3	1.5
Medication: Ibuprofen	1.2	1.4	2.7	-0.6	-1.4	-1.7	-0.9	-1.2
Supplements: Calcium	1.2	1.3	2.4	-0.4	1.0	1.3	1.1	1.6
Respiratory disease	1.1	2.4	3.8	-0.9	1.9	-1.9	-1.4	-1.4
Severe depression (siblings)	1.1	1.2	1.5	-0.7	-1.2	-1.1	-1.2	-1.2
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.2	-1.3	0.3	-1.3	-1.5	-1.1
Chronic bronchitis/emphysema (mother)	1.1	1.2	2.8	-0.1	0.1	-1.7	-1.1	-1.4
Osteoporosis (self-reported)	1.1	1.3	1.9	1.3	1.4	0.6	1.2	1.1
Cardiovascular Disease	1.0	3.3	5.9	-1.4	-1.1	-1.8	-2.4	-2.1
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.9	0.2	0.1	1.7	0.9	1.5
Length of working week for main job	1.0	1.1	2.2	-0.2	-1.5	-1.1	-1.0	-1.1
Gout (self-reported)	1.0	1.4	2.5	1.6	0.5	0.8	1.4	1.2
Medication: Omeprazole	1.0	1.2	2.3	0.2	-0.1	1.5	1.2	1.4
Wears glasses or contact lenses	1.0	1.1	2.5	0.1	-0.6	-1.6	-1.0	-1.4
Eye problems/disorders: Glaucoma	1.0	1.2	1.5	0.7	1.2	1.1	1.2	1.1
Rheumatoid Arthritis	0.9	1.2	2.2	1.1	-0.8	1.5	0.9	1.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	5.2	0.1	2.3	-0.6	-0.5	-0.5
Pulse rate	0.9	1.5	2.5	-1.2	-1.6	-1.1	-1.5	-0.7
Pulse wave Arterial Stiffness index	0.9	1.0	2.7	-0.2	1.0	1.6	0.3	1.0
Glaucoma (self-reported)	0.9	1.0	1.4	0.6	0.7	1.2	1.2	1.2
Exposure to tobacco smoke outside home	0.9	1.1	2.3	-0.8	-0.5	-1.5	-1.0	-1.3
Wheeze or whistling in the chest in last year	0.9	1.6	3.2	0.3	0.7	-1.8	-1.4	-1.4
Suffer from ‘nerves’	0.9	1.4	2.8	1.4	-1.7	-0.8	-0.6	-1.1
Mother’s age at death	0.9	1.2	5.0	0.8	2.2	0.3	0.2	-0.3
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.1	0.5	-0.4	-1.4	-0.9	-1.4
Vitamin and mineral supplements	0.8	1.1	1.7	1.3	-0.5	-1.2	-0.6	-1.3
Had menopause	0.8	1.0	4.0	2.0	-0.2	-0.1	0.8	0.1
Falls in the last year	0.8	1.0	2.6	-1.1	1.6	0.4	0.4	1.0
Asthma	0.8	1.6	3.0	-0.6	1.5	-1.7	-1.2	-0.9
Medication: Seretide 50 evohaler	0.8	0.9	1.8	-0.6	0.3	-0.8	-1.3	-1.3
Heart disease (mother)	0.8	1.0	2.0	-0.8	0.7	1.4	0.5	1.2
Number of full sisters	0.8	1.0	2.4	-0.5	-0.5	-1.5	-0.9	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.5	-1.1	1.0	-1.2	-0.9	-0.7
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.7	-0.5	-0.6	-1.0	-1.2	-1.3
Miserableness	0.8	1.4	2.3	1.3	1.2	0.7	1.5	1.1
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.3	-1.1	0.7	-1.0	-1.0	-1.2
Average weekly fortified wine intake	0.7	0.9	4.0	-0.3	2.0	-0.3	0.0	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.5	-1.2	-0.6	-0.8	-0.9	-1.2
Serious illness, injury or assault to yourself	0.7	0.9	2.9	-1.7	-0.0	-0.6	-0.7	-0.9
High blood pressure	0.7	2.0	3.8	-0.3	-0.2	-1.8	-1.7	-1.9
Multivitamins +/- minerals	0.7	0.9	2.1	-0.6	-0.2	1.4	0.7	1.3
Depression (self-reported)	0.7	0.9	2.3	1.5	-0.7	0.5	1.0	0.6
Peak expiratory flow (PEF)	0.7	1.7	3.4	0.2	-0.6	1.6	1.5	1.9
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.5	-0.0	-1.0	-1.2	-0.5	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.3	1.5	0.4	0.9	0.9	0.6
Qualifications: College or University degree	0.7	2.1	3.9	-1.8	1.6	2.0	0.1	0.9
Hypertension (Self-reported)	0.7	1.9	3.6	-0.5	0.2	-1.6	-1.8	-1.9
Number of self-reported non-cancer illnesses	0.7	1.3	2.5	-0.6	0.5	-1.2	-1.6	-1.4
Commuting to job workplace: Public transport	0.7	0.8	1.2	0.7	0.8	0.9	0.8	1.1
Supplements: Fish oil (including cod liver oil)	0.7	1.0	1.8	-0.2	0.9	1.3	0.6	1.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.8	0.0	0.4	1.3	0.9	1.1
Pain experienced in last month	0.7	1.1	2.1	0.6	0.4	1.5	1.0	1.3
Schizophrenia vs Biploar Disorder	0.6	0.7	1.5	-0.8	0.7	0.8	0.6	1.2
Alzheimer’s Disease (in father)	0.6	0.7	1.2	-1.1	-0.7	-0.5	-0.8	-0.9
Primary Biliary Cirrhosis	0.6	0.9	1.9	-0.8	-0.1	-1.0	-1.4	-1.0
Blood Platelet Count	0.6	7.3	11.6	2.0	-1.0	3.4	3.1	3.2
Systolic Blood Pressure	0.6	3.2	5.3	1.2	1.5	2.3	1.6	2.1
Medication: Co-codamol	0.6	0.6	1.5	0.1	1.2	0.7	0.7	0.9
Age when periods started (menarche)	0.6	1.5	2.1	1.1	-0.9	1.1	1.4	1.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.3	-1.5	-0.3	-0.3	-0.8	-0.5
Heart attack	0.6	0.8	2.0	-1.4	0.7	-0.4	-0.6	-0.8
Diabetes (self-reported)	0.6	1.0	2.4	0.5	1.6	1.1	0.6	0.9
Medication: Simvastatin	0.6	0.9	2.0	-1.4	0.7	-0.1	-1.1	-0.8
Leg fat percentage (right)	0.6	2.3	4.1	0.6	-1.1	-2.0	-1.7	-1.8
Pulse wave peak to peak time	0.6	0.7	1.9	0.3	-1.0	-1.4	-0.0	-0.7
Had major operations	0.6	0.8	1.7	-1.3	-1.1	0.6	-0.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.4	-1.2	-1.5	-0.9	-1.1	-0.8
Long-standing illness, disability or infirmity	0.6	0.9	2.5	0.2	1.6	0.4	0.8	1.0
Friendships satisfaction	0.6	0.7	1.4	-0.3	-0.6	-0.9	-0.8	-1.2
Asthma (self-reported)	0.6	1.2	2.4	-0.4	1.5	-1.4	-1.0	-0.7
Medication: Aspirin	0.6	0.8	3.1	-0.4	1.8	0.4	0.6	0.6
Ever taken oral contraceptive pill	0.6	0.7	1.6	-0.2	-0.5	-0.5	-1.2	-1.1
Ever smoked	0.6	1.0	3.8	0.2	2.0	0.7	0.5	0.7
Average weekly beer plus cider intake	0.6	0.9	1.9	-0.1	-1.4	-1.0	-0.8	-0.9
Ever depressed for a whole week	0.6	0.7	1.1	-1.0	-0.8	-0.8	-0.9	-0.6
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.2	0.2	-0.1	1.7	1.4	1.8
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.2	-1.5	0.6	-0.6	-0.6	-0.8
Reaction Time	0.5	1.0	2.1	0.6	1.0	-1.4	-0.7	-1.1
Mean Putamen Volume	0.5	0.6	1.5	-0.7	0.2	-0.7	-0.8	-1.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.2	0.2	1.5	1.3	0.4	0.9
Stomach or abdominal pain in last month	0.5	0.6	2.1	-1.4	-0.2	-0.3	-0.7	-0.2
Nervous feelings	0.5	1.0	2.9	-0.3	-1.7	-0.6	-0.9	-0.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.5	-0.0	-0.2	0.6	0.9	1.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.7	-0.2	-1.3	-0.1	-1.0	-0.7
High blood pressure (siblings)	0.5	0.7	1.1	-0.5	-1.0	-0.9	-1.0	-0.8
Mean time to correctly identify matches	0.5	0.9	3.6	0.7	1.9	-0.7	-0.1	-0.4
Leg fat mass (right)	0.5	1.9	3.3	0.4	-1.1	-1.8	-1.5	-1.5
Supplements: Vitamin C	0.5	0.6	2.1	-1.5	0.7	0.4	-0.4	0.4
Ever had bowel cancer screening	0.5	0.5	2.3	-0.3	1.5	0.0	0.5	0.4
Commuting to job workplace: Walk	0.5	0.5	1.1	-1.1	0.6	-0.7	-0.6	-0.4
Hearing aid user	0.5	0.5	0.8	0.8	-0.3	0.8	0.9	0.7
Medication: Blood pressure	0.5	1.0	1.7	-0.4	-0.2	-1.2	-1.2	-1.3
Medication: Bendroflumethiazide	0.5	0.7	1.0	0.1	1.0	-0.8	-1.0	-1.0
Medication: Paracetamol	0.5	0.7	1.4	0.5	0.5	0.7	1.1	1.2
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.7	0.1	1.3	0.5	0.8	0.4
Depression (Nagel 2018)	0.4	0.6	1.6	-0.3	-0.2	-0.9	-0.7	-1.3
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.0	0.5	1.1	1.4	1.0	1.4
Ulcerative Colitis (UC)	0.4	0.7	1.5	-0.3	0.9	1.2	0.5	0.9
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.2	-1.8	-0.5	-0.3	-1.0	-0.5
Breast Cancer	0.4	1.0	1.6	-0.1	-1.3	-1.0	-1.0	-1.1
Schizophrenia (2014)	0.4	1.0	2.0	-1.2	0.1	-1.0	-1.4	-0.8
Triglycerides	0.4	0.7	1.2	-0.1	-1.1	-0.7	-0.9	-1.0
Blood Red Count	0.4	3.7	6.3	2.5	1.0	1.4	2.3	2.0
BMI	0.4	2.6	4.2	-0.9	-1.0	-1.8	-2.1	-1.8
Average weekly spirits intake	0.4	0.4	1.0	-0.2	-0.4	-0.5	-1.0	-0.8
Relative age of first facial hair	0.4	0.9	1.8	-0.7	-0.5	-0.9	-1.3	-1.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.8	0.8	-0.0	0.4	0.9	0.6
Angina	0.4	0.5	0.9	0.3	0.1	0.9	0.9	0.8
Townsend deprivation index at recruitment	0.4	0.5	0.9	0.9	0.1	0.7	0.7	1.0
Maternal smoking around birth	0.4	0.6	1.6	1.3	-0.3	-1.0	0.0	-0.4
Supplements: Glucosamine	0.4	0.5	0.7	-0.7	-0.1	-0.9	-0.8	-0.7
Pain all over the body in last month	0.4	0.5	1.0	1.0	0.8	0.5	0.7	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.6	0.8	-0.1	-0.8	-0.4	-1.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.2	0.8	-0.8	1.2	1.4	1.5
Lung cancer (father)	0.4	0.5	1.4	-0.3	-1.2	-0.1	-0.8	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.2	0.5	-1.5	0.8	1.3	1.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.8	-0.3	0.8	0.7	0.5	0.9
Birth weight	0.4	0.8	2.0	-0.0	-0.2	1.4	0.8	1.2
Worry too long after embarrassment	0.4	0.6	2.2	1.5	0.8	-0.0	0.0	-0.5
Health satisfaction	0.4	0.5	0.9	0.7	0.8	-0.9	-0.5	-0.5
Chest pain or discomfort	0.4	0.5	1.3	-0.5	-0.1	-0.7	-1.1	-0.8
Illnesses of father: Heart disease	0.4	0.6	1.3	0.1	0.8	1.1	0.6	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.2	0.1	1.1	0.6	0.4	0.6
Guilty feelings	0.4	0.7	1.7	1.3	0.4	0.5	1.0	0.4
Alcohol drinker status: Never	0.4	0.5	1.2	-0.0	-1.1	-0.3	-0.5	-1.1
Leg fat percentage (left)	0.4	1.4	2.2	0.7	-1.1	-1.5	-1.3	-1.3
Diastolic blood pressure, automated reading	0.4	1.4	4.7	0.9	-0.4	-2.2	-0.7	-0.9
Worry (Nagel 2018)	0.3	0.7	1.3	0.4	-1.1	-0.8	-0.8	-0.9
Coronary Artery Disease (CAD)	0.3	0.4	1.0	0.3	1.0	0.7	0.5	0.5
Fasting Glucose	0.3	0.4	1.0	0.5	1.0	0.8	0.2	0.3
HbA1C	0.3	0.3	0.6	0.5	-0.0	0.4	0.8	0.7
Neuroticism (2016)	0.3	0.5	1.1	1.1	-0.3	0.4	0.8	0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.7	0.5	0.5	0.6	0.8	0.5
Lung FVC	0.3	1.4	2.8	0.2	-0.8	-1.4	-1.2	-1.7
Hand grip strength (left)	0.3	0.7	3.3	-0.5	-1.8	-0.1	0.1	0.2
Number of treatments/medications taken	0.3	0.5	2.1	-0.2	1.4	0.3	0.4	0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	1.0	0.3	-0.6	-0.1	-0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.5	1.2	-0.1	0.2	0.2	-0.1
Medication: Atenolol	0.3	0.3	1.2	0.6	1.1	0.4	0.1	-0.0
Body mass index (BMI)	0.3	1.2	2.2	0.1	-0.4	-1.5	-1.4	-1.3
Waist circumference	0.3	1.2	2.1	-0.4	-1.3	-1.4	-1.2	-0.9
Allergy	0.3	0.8	1.6	0.1	-0.4	1.3	1.0	1.0
Fluid intelligence score	0.3	0.5	1.7	-1.3	-0.4	0.9	0.1	0.4
Arm fat percentage (right)	0.3	1.2	2.4	-0.0	-0.2	-1.5	-1.4	-1.4
Alcohol intake versus 10 years previously	0.3	0.5	1.3	1.1	0.9	-0.3	0.4	0.2
Hair/balding pattern: Pattern 3	0.3	0.5	0.8	-0.6	-0.7	-0.4	-0.7	-0.9
Illnesses of mother	0.3	0.4	0.7	0.4	-0.5	0.2	0.8	0.8
Exposure to tobacco smoke at home	0.3	0.3	0.7	-0.0	-0.9	-0.6	-0.5	-0.6
Number of children fathered	0.3	0.4	0.8	-0.4	-0.3	-0.3	-0.9	-0.8
Neck or shoulder pain in last month	0.3	0.4	1.2	0.1	1.1	-0.0	0.6	0.5
Angina (self-reported)	0.3	0.4	0.9	0.2	-0.0	1.0	0.7	0.7
Comparative height size at age 10	0.3	1.4	3.5	1.9	0.1	0.3	1.5	1.0
Overall health rating	0.3	0.6	2.2	0.7	1.5	-0.3	0.3	0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.3	-0.0	1.1	-0.3	-0.0	-0.4
Knee pain experienced in last month	0.3	0.5	0.9	0.7	-0.0	-1.0	-0.7	-0.8
Arm fat percentage (left)	0.3	1.3	2.5	0.1	0.1	-1.6	-1.4	-1.4
Diabetes diagnosed by doctor	0.3	0.5	1.4	0.2	1.2	0.7	0.3	0.6
Osteoarthritis (self-reported)	0.3	0.4	0.7	-0.8	0.4	-0.6	-0.6	-0.5
Illnesses of father: None of the above (group 1)	0.3	0.3	0.9	0.3	-1.0	-0.1	0.6	0.6
Average weekly champagne plus white wine intake	0.3	0.4	0.8	-0.7	-0.2	-0.5	-0.6	-0.9
Medication: Lisinopril	0.3	0.3	0.9	0.8	-0.3	0.9	0.2	-0.1
Unable to work because of sickness or disability	0.3	0.4	2.1	0.2	1.4	0.2	0.1	0.3
Pack years of smoking	0.3	0.5	1.1	0.8	1.0	-0.2	0.6	0.5
Leg fat mass (left)	0.3	1.2	2.0	0.6	-1.0	-1.4	-1.2	-1.1
Bipolar Disorder (2018)	0.2	0.2	0.4	0.6	-0.4	-0.4	-0.5	-0.6
Schizophrenia (2018)	0.2	0.3	0.6	-0.7	0.4	-0.8	-0.6	-0.4
Irritable Bowel Disease (IBD)	0.2	0.4	0.6	-0.7	0.6	0.8	0.3	0.7
LDL Cholesterol	0.2	0.3	1.3	-1.1	-0.2	0.6	0.0	0.1
Lupus	0.2	0.3	0.6	-0.2	0.7	-0.4	-0.5	-0.5
Height	0.2	4.5	8.3	2.3	0.9	1.4	2.9	2.6
Allergy or Eczema	0.2	0.5	1.0	0.3	0.0	-0.7	-0.8	-1.0
Hair Pigment	0.2	6.0	10.3	-0.8	-3.2	-2.5	-2.5	-2.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.8	0.1	-0.0	-0.8	-0.5	-0.9
Medication: Metformin	0.2	0.3	0.7	0.1	0.8	0.7	0.4	0.4
Diabetes (mother)	0.2	0.2	0.5	-0.2	-0.5	0.7	0.1	0.5
Pack years adult smoking proportion	0.2	0.3	0.8	0.7	0.9	-0.4	0.4	0.2
Hand grip strength (right)	0.2	0.6	1.7	-0.1	-1.3	0.5	0.7	0.8
Current tobacco smoking	0.2	0.3	0.7	-0.0	-0.3	-0.6	-0.9	-0.5
Fed-up feelings	0.2	0.3	0.4	0.4	0.6	0.6	0.5	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	-0.6	1.0	0.6	0.5	0.5
Qualifications: CSEs or equivalent	0.2	0.3	0.5	0.7	-0.7	-0.6	0.4	-0.2
High blood pressure (mother)	0.2	0.3	0.7	0.8	0.4	0.3	0.6	0.5
Impedance of leg (left)	0.2	1.1	1.4	0.9	-1.0	1.1	1.2	1.0
Past tobacco smoking	0.2	0.3	1.6	-0.2	-1.3	-0.2	0.0	0.0
Medication: Ramipril	0.2	0.3	1.1	-1.1	0.1	-0.4	-0.4	-0.3
Neuroticism score	0.2	0.3	1.1	1.1	-0.4	-0.3	-0.0	-0.6
Hip circumference	0.2	0.8	1.8	0.0	-0.5	-1.4	-1.1	-0.9
Time employed in main current job	0.2	0.2	0.6	0.7	0.1	-0.3	-0.3	-0.7
Father’s age at death	0.2	0.3	0.7	0.8	0.3	0.2	0.6	0.4
Medication: Cholesterol lowering	0.2	0.4	1.6	-1.3	0.3	0.1	-0.3	0.1
Arm fat mass (right)	0.2	1.0	2.4	0.3	-0.3	-1.5	-1.1	-1.1
Standing height	0.2	2.2	4.0	1.3	0.1	1.2	2.0	2.0
Pulse wave reflection index	0.2	0.2	1.0	-0.1	1.0	0.4	-0.0	0.0
Loud music exposure frequency	0.2	0.2	0.8	-0.3	-0.9	-0.1	0.1	0.0
Blood clot in the leg (DVT)	0.2	0.3	0.5	-0.4	-0.1	-0.7	-0.6	-0.7
Medication: Paracetamol	0.2	0.3	0.8	0.0	0.9	-0.1	0.5	0.7
Forced vital capacity (FVC), Best measure	0.2	0.7	3.0	-0.1	-1.7	-0.5	-0.1	-0.1
Body fat percentage	0.2	1.0	1.9	0.3	-0.3	-1.4	-1.2	-1.1
Medication for pain relief, constipation, heartburn	0.2	0.4	1.0	1.0	-0.7	0.3	-0.4	-0.2
Medication: Blood pressure	0.2	0.3	1.2	-0.2	1.1	-0.2	-0.4	-0.4
Whole body fat mass	0.2	1.0	2.1	0.4	-0.5	-1.5	-1.1	-1.0
Pulse rate, automated reading	0.2	0.6	1.4	-0.8	-1.2	-0.5	-0.7	-0.2
Alcohol intake frequency.	0.2	0.4	0.9	0.4	-0.3	-1.0	-0.4	-0.9
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	-0.4	-0.7	-0.5	-0.0	0.2
Loneliness, isolation	0.2	0.3	1.3	-0.5	-1.1	-0.4	-0.1	-0.2
Smoking status: Current	0.2	0.3	0.8	-0.2	-0.2	-0.5	-0.9	-0.5
Arm fat mass (left)	0.2	0.8	2.0	0.5	-0.0	-1.4	-1.0	-0.9
Risk taking	0.2	0.3	1.1	-0.7	-1.0	0.2	-0.1	0.0
Fractured/broken bones in last 5 years	0.2	0.2	1.1	-1.0	0.1	-0.1	-0.2	0.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	-0.3	0.2	-0.7	-0.6	-0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.7	-0.1	-0.0	-0.8	-0.7	-0.6
Depressed Affect (Nagel 2018)	0.1	0.3	0.5	0.7	0.7	0.2	0.6	0.3
Major Depression (MDD)	0.1	0.2	0.4	0.6	-0.4	0.0	0.5	0.1
Crohns Disease (2012)	0.1	0.1	0.3	-0.4	-0.5	0.2	-0.4	0.0
HDL Cholesterol	0.1	0.2	0.6	-0.4	-0.2	0.8	0.2	0.5
Blood Eosinophil Count	0.1	0.9	2.2	1.5	-0.9	0.6	0.8	0.6
Heel T-Score	0.1	1.1	3.0	-0.3	-1.7	-0.7	-0.6	-1.3
Waist Hip Ratio (WHR)	0.1	0.3	1.2	0.1	-1.1	-0.3	0.3	0.1
Neuroticism	0.1	0.3	0.9	0.9	0.2	0.6	0.6	0.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	0.3	0.4	0.1	-0.3	-0.2
Supplements: Zinc	0.1	0.1	0.4	-0.6	0.1	0.3	0.0	0.1
Impedance of leg (right)	0.1	0.5	1.0	0.9	-1.0	0.3	0.6	0.3
Trunk fat percentage	0.1	0.4	0.8	0.5	-0.1	-0.9	-0.6	-0.6
Taking other prescription medications	0.1	0.2	0.7	0.0	0.9	-0.0	0.2	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.2	-0.4	-0.6	-0.1	-0.4
Sitting height	0.1	0.4	0.9	0.9	-0.0	-0.3	0.9	0.4
Trunk fat mass	0.1	0.5	1.1	0.6	-0.2	-1.0	-0.7	-0.6
Forced vital capacity (FVC)	0.1	0.3	0.9	0.6	-1.0	-0.3	0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	1.1	-1.0	-0.0	-0.2	0.1	0.1
Mouth/teeth dental problems	0.1	0.2	0.4	0.3	-0.2	0.3	0.5	0.6
Weight	0.1	0.4	0.9	0.7	-0.3	-0.9	-0.5	-0.5
Impedance of arm (right)	0.1	0.2	0.8	-0.9	-0.6	0.2	0.2	0.1
Worrier / anxious feelings	0.1	0.2	0.4	-0.6	-0.1	0.5	0.2	0.6
Number of live births	0.1	0.1	0.2	0.2	-0.3	-0.5	-0.1	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.5	-0.4	0.1	0.3	-0.0
Birth weight of first child	0.1	0.1	0.5	0.7	0.4	0.1	0.1	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.9	0.5	-1.0	-0.3	0.2	0.0
Comparative body size at age 10	0.1	0.3	1.5	0.2	1.2	0.0	-0.2	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.6	0.2	0.1	0.8	-0.0	0.1
Shortness of breath walking on level ground	0.1	0.1	0.2	0.1	-0.2	-0.4	-0.5	-0.4
Arm predicted mass (right)	0.1	0.3	0.9	0.7	0.1	-0.9	-0.2	-0.3
Age at last live birth	0.1	0.1	0.2	0.3	-0.1	0.4	0.4	0.0
Leg pain on walking	0.1	0.1	0.2	0.2	0.5	0.1	0.3	0.4
Illnesses of siblings: Diabetes	0.1	0.2	0.3	0.4	-0.5	0.4	0.4	0.4
Smoking status: Previous	0.1	0.1	0.3	0.1	0.5	-0.2	-0.2	-0.2
Mood swings	0.1	0.1	0.2	0.5	0.0	-0.5	-0.1	-0.4
Qualifications: nursing, teaching	0.1	0.1	0.7	-0.1	0.8	0.2	0.1	0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	0.1	0.4	0.5	0.6	0.6
Medication for cholesterol	0.1	0.1	0.4	-0.1	-0.7	-0.3	-0.2	0.0
Back pain experienced in last month	0.1	0.1	0.3	-0.5	-0.4	-0.1	-0.2	0.3
Breast cancer (self-reported)	0.1	0.2	0.5	-0.2	-0.3	0.7	0.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.5	0.2	-0.2	0.7	0.6	0.7
Financial situation satisfaction	0.1	0.1	0.4	0.6	0.1	0.1	0.2	0.1
High cholesterol (Self-reported)	0.1	0.2	0.5	-0.7	-0.4	0.0	-0.3	-0.1
Arm fat-free mass (left)	0.1	0.3	0.7	0.6	-0.4	-0.8	-0.2	-0.1
Number of operations (self-reported)	0.1	0.2	0.4	-0.5	-0.6	0.3	-0.2	-0.4
Age started oral contraceptive pill	0.1	0.1	0.2	-0.2	0.1	0.3	-0.4	-0.1
Cholesterol lowering medication	0.1	0.1	0.5	-0.7	0.1	-0.2	-0.3	-0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.4	-0.1	0.6	0.3	0.0	0.3
Impedance of whole body	0.1	0.5	0.8	0.1	-0.5	0.9	0.9	0.8
Neuroticism (Nagel 2018)	0.0	0.1	0.3	0.5	0.1	-0.1	-0.1	-0.5
Crohns Disease (2017)	0.0	0.1	0.1	-0.4	0.2	0.1	0.1	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Smoking Status	0.0	0.1	0.3	0.6	0.2	-0.0	-0.1	0.3
Chronotype (morning person)	0.0	0.1	0.1	-0.1	0.2	0.3	0.1	0.4
Tanning	0.0	0.1	0.2	-0.3	0.5	-0.2	-0.2	-0.1
Sensitivity / hurt feelings	0.0	0.1	0.1	-0.0	-0.1	0.4	0.1	-0.4
Leg fat-free mass (left)	0.0	0.2	0.7	0.0	0.1	-0.9	-0.4	-0.3
Relative age voice broke	0.0	0.1	0.1	0.3	-0.0	0.4	-0.2	0.2
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.0	-0.4	-0.3	-0.3	-0.3
Leg predicted mass (left)	0.0	0.2	0.8	0.1	0.2	-0.9	-0.4	-0.3
Trunk fat-free mass	0.0	0.2	0.4	0.6	0.4	-0.6	0.2	0.2
Impedance of arm (left)	0.0	0.2	0.4	-0.2	0.5	0.5	0.6	0.5
Trunk predicted mass	0.0	0.2	0.4	0.6	0.4	-0.5	0.2	0.2
Arm fat-free mass (right)	0.0	0.3	0.8	0.9	-0.1	-0.7	0.1	0.0
Age at first live birth	0.0	0.1	0.1	-0.4	-0.1	0.0	-0.3	-0.3
Emphysema/chronic bronchitis	0.0	0.0	0.1	-0.1	0.2	-0.1	0.3	0.2
Family relationship satisfaction	0.0	0.0	0.0	0.1	-0.2	-0.1	-0.1	-0.1
Whole body fat-free mass	0.0	0.1	0.5	0.4	0.2	-0.7	-0.0	-0.0
Leg fat-free mass (right)	0.0	0.1	0.2	0.0	0.1	-0.5	-0.1	0.0
Whole body water mass	0.0	0.1	0.6	0.3	0.2	-0.8	-0.1	-0.1
Leg predicted mass (right)	0.0	0.1	0.2	0.1	0.2	-0.5	-0.1	0.1
Basal metabolic rate	0.0	0.2	0.6	0.5	0.1	-0.8	-0.1	-0.1
Myopia	0.0	0.0	0.1	0.2	-0.1	-0.2	-0.3	-0.2
Arm predicted mass (left)	0.0	0.2	0.5	0.7	-0.3	-0.7	0.0	0.0

Hub : Genes

GPR157

Models

Trait associations