Hub : Genes

GPR85

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0410 0.0180 3.5e-03 0.020 0.005 -0.002 0.005 0.005 1.6e-03 7.2e-02 7.2e-01 0.067 7.5e-02
2 TCGA Breast Invasive Carcinoma 0.0581 0.0215 2.4e-10 0.018 0.056 0.046 NA 0.045 9.9e-05 1.6e-11 1.1e-09 NA 1.4e-09
3 TCGA Kidney Renal Clear Cell Carcinoma 0.0265 0.0143 9.9e-03 0.007 0.008 0.001 NA 0.004 4.4e-02 3.5e-02 2.1e-01 NA 1.1e-01
4 TCGA Testicular Germ Cell Tumors 0.1150 0.0620 5.8e-03 0.041 0.040 0.025 NA 0.055 1.4e-02 1.5e-02 4.5e-02 NA 5.2e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 2.5 4.0 7.8 -0.5 -1.9 -2.1 -2.8
Bipolar Disorder or Schizophrenia 0.9 2.1 5.2 -0.5 -1.0 -1.4 -2.3
Depressed Affect (Nagel 2018) 1.1 2.4 4.0 2.0 -0.3 -1.9 -1.4
Depression (Nagel 2018) 0.9 1.4 2.8 1.4 -0.8 -1.7 -0.1
Intelligence (Savage-Jansen 2018) 0.1 0.4 0.9 -0.4 -0.9 -0.6 -0.2
Neuroticism (Nagel 2018) 0.4 1.0 2.1 1.0 0.2 -0.8 -1.4
Schizophrenia (2018) 0.1 0.1 0.4 -0.2 0.2 -0.1 -0.7
Schizophrenia vs Biploar Disorder 1.5 2.0 4.1 0.1 2.0 1.9 0.6
Worry (Nagel 2018) 0.1 0.2 0.4 0.7 0.2 -0.2 -0.3
Alzheimer’s Disease (in mother) 0.6 0.7 2.8 0.3 -0.0 0.1 -1.7
Alzheimer’s Disease (in father) 0.3 0.4 0.6 -0.8 -0.1 0.5 -0.8
Alzheimer’s Disease (including proxy) 0.1 0.2 0.4 0.0 0.4 0.7 -0.4
Crohns Disease (2017) 0.6 1.4 3.7 -1.1 -0.5 -1.9 -0.7
Irritable Bowel Disease (IBD) 0.1 0.3 0.8 0.1 0.2 -0.9 -0.7
Ulcerative Colitis (UC) 0.2 0.3 0.7 0.8 0.5 -0.0 -0.5
Major Depression (MDD) 2.2 2.7 5.3 0.2 -1.9 -1.3 -2.3
Reaction Time 0.2 0.3 0.9 -0.9 0.3 -0.3 0.4
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.5 -0.6 -0.5 -0.7 -0.5
Breast Cancer 0.3 0.8 2.4 1.5 0.3 -0.1 0.8
Ovarian Cancer 0.9 1.2 3.1 -1.3 -0.1 0.2 1.8
Prostate Cancer 0.3 0.4 1.1 0.5 1.0 0.2 0.3
Age at First Birth 0.9 1.3 2.9 -0.2 1.7 1.4 -0.7
Bipolar Disorder (2011) 1.6 1.5 3.2 -0.8 -1.3 -0.7 -1.8
Body Mass Index (BMI) (2010) 1.7 2.3 4.5 2.1 1.2 1.1 1.4
Coronary Artery Disease (CAD) 1.3 1.5 4.0 2.0 0.8 -0.0 1.2
Crohns Disease (2012) 0.3 0.5 1.7 -0.4 -0.1 -1.3 -0.4
Mean Putamen Volume 0.4 0.5 1.0 -1.0 -0.4 -0.4 0.8
Fasting Glucose 0.7 0.8 1.5 0.8 1.0 1.2 -0.2
HbA1C 0.6 0.6 1.8 1.3 0.7 0.4 0.1
HDL Cholesterol 1.0 1.6 5.0 -2.2 -1.0 -0.1 -0.7
LDL Cholesterol 0.1 0.1 0.4 -0.0 -0.6 -0.4 -0.0
Lupus 0.4 0.7 1.5 -1.2 -0.1 -1.0 -0.4
Neuroticism (2016) 0.5 0.8 2.0 0.8 1.4 0.6 0.2
Primary Biliary Cirrhosis 1.0 1.4 3.7 0.3 -0.5 -1.2 -1.9
Rheumatoid Arthritis 0.1 0.2 0.6 0.0 -0.4 -0.8 0.1
Schizophrenia (2014) 0.2 0.4 0.9 -0.4 0.8 0.1 -1.0
Triglycerides 0.7 1.1 2.2 1.5 -0.7 -1.3 0.3
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.6 0.6 0.4 0.9 1.3
Ulcerative Colitis 0.2 0.3 0.6 -0.0 0.8 0.6 -0.4
Blood Eosinophil Count 1.0 8.1 15.8 -2.7 -1.4 -2.7 -4.0
Blood Platelet Count 0.0 0.3 0.7 0.3 -0.8 0.5 0.5
Blood Red Count 0.1 1.4 4.0 2.0 -0.7 -0.8 0.6
Blood White Count 0.2 1.4 3.4 0.6 -1.1 -1.8 -0.8
Heel T-Score 0.1 0.5 1.0 0.8 0.4 1.0 -0.3
BMI 1.4 8.2 27.7 5.3 -0.9 -2.0 0.4
Height 0.2 3.3 12.3 3.5 -0.8 -0.2 -0.5
Waist Hip Ratio (WHR) 0.2 1.0 2.2 -0.4 -1.2 -1.5 0.2
Systolic Blood Pressure 0.1 0.4 1.0 0.7 -0.4 -0.2 1.0
Smoking Status 0.9 2.1 5.1 -0.3 -1.2 -2.3 -1.4
Allergy or Eczema 1.1 3.0 6.0 -2.5 0.9 1.1 2.0
Cardiovascular Disease 0.5 1.8 3.3 0.5 -1.7 -1.8 0.8
Hypothyroidism (self reported) 0.3 0.7 2.2 -1.5 0.3 0.7 0.1
Respiratory disease 0.1 0.3 0.7 -0.2 0.8 0.7 0.0
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.3 1.5 -0.5 -0.9 1.1
Lung FEV1/FVC ratio 0.1 0.7 1.7 0.6 -0.8 -1.3 0.2
Lung FVC 0.2 1.0 2.6 -1.6 -0.9 -0.6 0.2
Neuroticism 0.5 1.1 2.3 0.7 -0.0 -1.3 -1.5
Chronotype (morning person) 0.3 0.7 2.3 -0.2 0.5 1.5 0.3
Hair Pigment 0.0 0.5 1.2 -0.7 -0.3 0.1 -1.1
Tanning 0.0 0.6 1.2 1.1 -0.4 -1.0 -0.2
Hand grip strength (left) 1.1 2.9 11.1 0.0 0.1 0.7 3.3
Number of treatments/medications taken 2.3 4.2 7.9 1.2 -2.7 -2.8 -0.5
Average weekly spirits intake 0.1 0.1 0.3 0.6 -0.1 0.0 -0.5
Sensitivity / hurt feelings 0.1 0.2 0.5 -0.4 0.4 -0.0 -0.7
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.7 0.2 0.2 -0.8 0.4
Hearing difficulty/problems: Yes 0.6 0.9 3.4 -1.8 -0.1 0.0 -0.1
Relative age of first facial hair 0.4 0.8 1.7 1.3 -0.7 -0.2 0.9
Other serious medical condition/disability diagnosed by doctor 1.6 2.0 4.1 0.6 -1.4 -2.0 -1.3
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.0 1.4 0.2 -0.4 -1.2
Ever had hysterectomy (womb removed) 0.2 0.2 0.7 0.8 0.1 0.3 0.1
Systolic blood pressure, automated reading 0.6 1.8 3.7 1.9 -1.3 -1.1 -0.9
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 -0.2 0.3 0.5 0.3
Angina 0.3 0.3 0.8 -0.5 0.5 0.4 0.9
Medication for hormone replacement therapy 1.3 1.5 3.4 -0.5 1.1 1.8 1.1
Vitamin and mineral supplements 0.9 1.2 4.5 0.3 -0.5 0.3 -2.1
Supplements: Zinc 2.4 2.6 6.4 -0.5 2.5 1.1 1.6
Medication: Co-codamol 0.2 0.3 0.5 -0.5 -0.6 -0.7 -0.1
Medication: Metformin 1.5 2.1 3.5 1.9 -1.5 -1.6 -0.0
Diabetes (father) 1.3 1.7 3.1 1.5 -0.7 -1.0 -1.8
Diabetes (mother) 1.1 1.4 3.3 1.0 -0.7 -1.8 -0.8
Severe depression (siblings) 0.4 0.5 1.4 -1.2 -0.0 0.7 0.1
Pack years adult smoking proportion 0.2 0.3 0.8 0.0 0.2 0.5 0.9
Impedance of leg (right) 1.0 4.9 8.7 -0.9 2.5 3.0 2.0
Leg fat-free mass (left) 1.1 5.6 12.5 3.5 -1.9 -2.3 -1.0
Trunk fat percentage 1.3 5.2 15.6 3.9 -1.1 -1.9 0.4
Hand grip strength (right) 0.7 1.8 5.7 0.3 0.6 1.0 2.4
Townsend deprivation index at recruitment 0.1 0.2 0.5 -0.7 -0.2 -0.4 0.0
Current tobacco smoking 0.2 0.3 0.7 -0.9 0.7 -0.3 -0.2
Average weekly fortified wine intake 0.9 1.0 2.1 -0.3 1.4 1.3 -0.4
Maternal smoking around birth 0.5 0.8 1.6 -0.1 -1.1 -1.3 -0.5
Fed-up feelings 0.2 0.3 0.8 -0.1 0.9 -0.4 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.6 0.6 -0.4 -1.3 0.6
Relative age voice broke 1.6 2.5 4.9 0.5 1.7 1.4 2.2
Taking other prescription medications 0.2 0.3 0.6 0.8 -0.2 -0.8 0.1
Age when periods started (menarche) 0.7 1.7 4.0 0.5 -2.0 -1.6 0.1
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.4 0.6 0.7 0.2 0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.1 0.3 -0.0 0.0 0.5 -0.0
Tinnitus: Yes, but not now, but have in the past 2.1 2.2 5.9 -0.6 -1.3 -1.0 -2.4
Qualifications: CSEs or equivalent 1.2 1.5 5.2 -2.3 0.8 0.5 -0.0
Serious illness, injury or assault to yourself 0.4 0.5 1.0 0.8 -0.6 -1.0 -0.3
High blood pressure 1.4 3.8 7.8 -0.3 -2.8 -2.7 -0.4
Hayfever, allergic rhinitis or eczema 1.6 3.4 10.7 -3.3 0.5 0.9 1.3
Multivitamins +/- minerals 0.4 0.6 1.6 -0.4 0.0 -0.7 1.3
Stomach or abdominal pain in last month 1.2 1.5 4.6 -2.1 0.9 -0.2 0.7
Supplements: Glucosamine 1.1 1.4 3.1 0.8 -1.8 -1.2 -0.8
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 2.6 -0.1 -1.6 -1.6 -0.3
Medication: Atenolol 0.1 0.2 0.3 -0.1 -0.3 -0.6 0.5
Medication: Levothyroxine sodium 0.4 0.7 1.0 -1.0 0.8 0.9 0.5
Sitting height 0.1 0.7 1.2 0.5 -1.1 -0.7 -1.1
Chronic bronchitis/emphysema (father) 0.8 1.0 2.3 -0.6 1.0 0.4 1.5
High blood pressure (mother) 0.6 0.9 3.3 0.2 0.3 1.8 -0.1
Body mass index (BMI) 1.5 6.4 17.6 4.2 -1.4 -2.4 -0.7
Impedance of leg (left) 0.7 3.5 4.7 -1.0 2.0 2.2 2.1
Leg predicted mass (left) 1.0 5.6 12.5 3.5 -1.9 -2.3 -1.0
Trunk fat mass 1.6 7.0 21.0 4.6 -1.4 -2.2 0.1
Waist circumference 1.9 6.8 15.9 4.0 -1.4 -3.0 -0.6
Number of incorrect matches in round 0.4 0.6 1.4 -1.2 -0.1 0.9 -0.3
Past tobacco smoking 1.6 2.9 5.5 0.1 1.5 2.3 1.9
Alcohol usually taken with meals 0.4 0.7 1.4 -0.1 0.7 0.9 1.2
Nervous feelings 0.1 0.3 0.5 -0.6 0.2 -0.7 -0.4
Frequency of tenseness / restlessness in last 2 weeks 2.2 3.4 6.6 -0.6 -1.4 -2.6 -2.2
Hearing difficulty/problems with background noise 1.0 1.6 6.0 -2.5 0.2 -0.3 0.5
Hair/balding pattern: Pattern 2 0.1 0.2 0.3 -0.1 -0.6 -0.3 -0.5
Had menopause 1.0 1.2 2.3 1.0 -0.7 -1.0 -1.5
Had other major operations 0.3 0.4 0.6 0.7 0.8 -0.6 0.2
Forced vital capacity (FVC) 0.2 0.8 2.5 -1.6 -0.4 -0.1 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.9 0.3 0.4 0.9 -0.0
Ever unenthusiastic/disinterested for a whole week 1.7 2.1 3.8 1.1 -1.0 -1.9 -1.6
Qualifications: None of the above 0.9 1.9 3.4 1.8 -1.1 -1.6 -0.6
Financial difficulties in last 2 years 0.8 1.0 2.0 0.8 -0.8 -1.4 -0.9
Mouth/teeth dental problems 0.2 0.4 0.8 -0.2 -0.9 -0.2 -0.7
Heart attack 1.1 1.5 4.1 -1.0 0.6 0.6 2.0
Allergy 1.4 3.2 10.8 3.3 -0.7 -0.8 -0.9
Pain all over the body in last month 0.5 0.6 1.6 1.3 0.7 0.3 -0.1
Diabetes (self-reported) 0.9 1.5 3.3 1.8 -1.0 -1.0 -0.7
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 3.1 -1.8 0.8 1.1 0.8
Medication: Ramipril 2.7 3.5 5.4 0.4 -2.2 -2.3 -1.8
Medication: Simvastatin 0.3 0.5 1.1 0.8 -0.5 -1.0 -0.2
Fluid intelligence score 0.6 1.2 3.0 -0.1 -1.7 -1.0 -0.9
Illnesses of siblings 0.4 0.5 0.9 0.5 0.9 0.9 0.4
Neuroticism score 0.4 0.8 1.6 -0.4 0.4 -1.2 -1.1
Weight 1.5 7.6 22.4 4.7 -1.4 -2.4 -0.6
Impedance of arm (right) 0.3 1.6 3.6 -1.9 0.7 1.2 0.8
Arm fat percentage (right) 1.5 6.0 18.1 4.2 -1.0 -2.2 -0.2
Trunk fat-free mass 0.6 3.3 9.9 3.1 -1.0 -1.3 -0.8
Hip circumference 1.1 4.8 15.8 4.0 -0.4 -1.8 0.1
Time employed in main current job 0.5 0.5 0.7 -0.7 0.8 0.8 0.6
Alcohol intake versus 10 years previously 0.3 0.4 0.9 -0.4 -0.6 -0.9 0.5
Father’s age at death 0.2 0.3 0.7 -0.6 -0.0 0.8 0.4
Worrier / anxious feelings 0.5 1.0 3.0 -0.4 -0.6 -1.7 -0.7
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 1.8 1.0 0.2 -1.3 -1.0
Falls in the last year 1.8 2.4 5.8 2.4 -0.6 -1.6 -0.9
Hair/balding pattern: Pattern 3 0.3 0.4 0.8 -0.9 0.6 0.2 0.7
Number of live births 1.4 2.0 4.8 -1.2 -1.3 -2.2 0.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 1.6 -1.3 -0.3 0.1 0.5
Pulse rate 1.3 2.2 7.5 2.7 -0.6 -0.7 -0.6
Happiness 1.3 1.6 3.8 1.9 -0.2 -0.3 -1.6
Noisy workplace 0.4 0.5 1.1 0.6 -0.3 0.6 -1.1
Qualifications: A levels/AS levels or equivalent 0.3 0.7 2.2 0.5 -0.6 -0.4 -1.5
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.9 -0.4 -0.7 -1.4 0.6
Mouth/teeth dental problems: Dentures 0.3 0.5 1.2 1.1 -0.1 -0.5 -0.7
Asthma 0.2 0.4 1.2 -1.1 0.3 0.1 0.5
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 1.0 0.5 -0.0 -0.0 1.0
Medication: Cholesterol lowering 0.5 0.8 1.5 -0.4 -1.2 -1.2 -0.3
Depression (self-reported) 0.4 0.4 1.5 -1.2 0.3 -0.5 -0.1
Medication: Lansoprazole 2.1 2.3 4.4 1.7 -0.4 -1.4 2.1
Prospective memory result 3.5 4.4 8.9 0.8 1.7 2.2 3.0
Lung cancer (father) 2.2 2.5 5.4 0.1 1.5 1.6 2.3
Illnesses of mother 1.5 1.8 4.3 -1.3 1.1 0.4 2.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.6 -0.8 -0.7 -0.1 0.2
Pulse wave Arterial Stiffness index 0.5 0.6 1.0 1.0 0.6 0.7 0.6
Impedance of arm (left) 0.3 1.4 4.9 -2.2 -0.1 0.4 0.8
Arm fat mass (right) 1.7 7.0 21.7 4.7 -1.2 -2.2 -0.3
Trunk predicted mass 0.6 3.5 10.3 3.2 -1.0 -1.4 -0.9
Standing height 0.1 0.9 3.0 1.7 -0.5 -0.4 -0.2
Length of working week for main job 1.2 1.3 2.6 1.6 0.9 1.4 0.0
Exposure to tobacco smoke at home 0.4 0.5 1.1 -0.3 0.6 1.1 -0.4
Breastfed as a baby 0.6 0.7 1.1 -0.8 0.6 1.0 0.9
Tense / ‘highly strung’ 0.2 0.4 0.6 -0.8 0.7 0.4 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 4.3 0.1 -1.6 -2.1 -1.0
Hair/balding pattern: Pattern 4 0.2 0.4 1.1 0.1 0.6 1.1 -0.3
Birth weight of first child 0.1 0.2 0.6 0.7 -0.4 0.4 -0.4
Peak expiratory flow (PEF) 0.2 0.5 1.7 -1.3 0.3 0.3 0.5
Pulse wave reflection index 0.1 0.1 0.3 -0.1 0.2 0.6 -0.1
Ever highly irritable/argumentative for 2 days 1.0 1.2 3.5 1.9 -0.3 -0.2 -1.1
Loud music exposure frequency 4.3 4.7 14.5 -0.1 -1.6 -1.3 -3.8
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.6 -0.0 0.8 -0.0 0.5
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 4.7 -0.2 -0.1 -0.6 2.2
Blood clot in the leg (DVT) 0.5 0.6 1.6 0.9 0.0 0.2 -1.3
Medication: Paracetamol 0.7 1.1 1.8 0.6 -0.8 -1.3 -1.2
Headache pain in last month 0.5 0.9 1.9 -0.1 -0.4 -1.4 1.2
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 4.6 0.5 2.1 2.1 -0.2
Glaucoma (self-reported) 0.4 0.4 1.0 0.4 1.0 0.6 0.5
Gout (self-reported) 0.1 0.2 0.5 -0.4 0.1 0.7 0.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.2 -1.1 -0.2 0.2 -0.3
Medication: Amlodipine 1.8 2.5 5.9 -0.9 -2.4 -1.8 -0.4
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.0 -1.0 -0.6 -0.5 -0.1
Birth weight 0.2 0.4 0.7 0.6 -0.8 -0.4 0.6
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.4 -0.1 -0.3 -0.6 0.5
High blood pressure (siblings) 0.5 0.7 2.6 -1.6 -0.4 -0.0 0.3
Forced vital capacity (FVC), Best measure 0.1 0.3 0.8 -0.9 -0.6 0.0 0.5
Body fat percentage 1.5 6.1 19.1 4.4 -0.9 -2.0 0.4
Leg fat percentage (right) 1.6 5.8 19.8 4.4 -0.6 -1.8 -0.0
Arm fat-free mass (right) 0.8 4.1 12.1 3.5 -1.2 -1.7 -0.5
Exposure to tobacco smoke outside home 3.3 4.5 6.7 0.3 2.5 2.6 2.1
Comparative body size at age 10 0.3 0.7 2.6 0.6 0.1 -0.1 1.6
Number of full brothers 1.5 1.9 3.8 -0.3 -1.6 -1.9 -1.0
Worry too long after embarrassment 0.9 1.5 3.8 -1.2 0.1 -0.9 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.3 0.1 -0.1 -0.4 -0.6
Wheeze or whistling in the chest in last year 0.4 0.6 2.2 -1.5 0.6 -0.3 -0.2
Number of children fathered 0.4 0.5 0.8 -0.1 0.9 0.5 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.8 2.0 -1.4 -0.3 0.8 -0.5
Age at first live birth 0.4 0.7 1.2 1.0 -1.1 -0.4 -0.8
Pulse wave peak to peak time 0.4 0.5 0.7 -0.8 -0.6 -0.8 -0.7
Health satisfaction 0.8 1.0 3.7 1.9 0.6 -0.2 -0.2
Shortness of breath walking on level ground 0.5 0.6 0.9 0.9 0.8 -0.4 0.9
Qualifications: College or University degree 0.7 2.1 5.4 -2.3 -0.6 0.1 -1.6
Eye problems/disorders: None of the above 1.6 1.9 2.8 0.5 1.7 1.5 1.5
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.3 -0.1 0.6 0.5 0.1
Emphysema/chronic bronchitis 1.0 1.1 1.9 -0.9 1.3 0.3 -1.4
Medication for pain relief, constipation, heartburn 1.6 2.7 5.1 -1.1 2.0 2.3 0.5
Neck or shoulder pain in last month 2.7 3.8 14.2 -0.3 1.0 -0.1 3.8
Medication: Blood pressure 0.9 1.7 4.0 -0.2 -2.0 -1.6 -0.3
Angina (self-reported) 0.2 0.3 0.5 -0.6 0.4 0.2 0.7
Migraine (self-reported) 0.1 0.2 0.3 -0.6 0.4 -0.0 0.4
Medication: Ibuprofen 0.0 0.1 0.1 0.4 0.1 0.1 0.3
Medication: Allopurinol 0.3 0.4 0.9 -0.5 -0.8 -0.9 -0.0
Medication: Omeprazole 1.0 1.1 3.9 -0.7 0.1 -0.5 2.0
Medication: Seretide 50 evohaler 0.4 0.5 1.3 -0.4 -0.4 -0.5 -1.1
Mean time to correctly identify matches 0.4 0.7 1.3 0.1 -0.7 -1.1 -1.0
Heart disease (mother) 2.6 3.2 6.8 -0.6 -1.7 -1.6 -2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.1 -1.0 -0.7 -0.6 -0.7
Whole body fat mass 1.9 8.1 25.1 5.0 -1.2 -2.4 0.1
Leg fat mass (right) 2.1 8.2 26.2 5.1 -1.1 -2.3 -0.1
Arm predicted mass (right) 0.9 4.8 13.2 3.6 -1.5 -1.8 -0.9
Pulse rate, automated reading 0.7 2.3 4.3 2.1 -1.4 -1.4 -0.9
Alcohol intake frequency. 0.7 1.6 3.5 0.5 -1.4 -1.9 -1.0
Comparative height size at age 10 0.2 0.8 1.8 1.3 -0.4 -0.6 -1.1
Number of full sisters 1.7 2.1 4.0 -0.2 -1.5 -2.0 -1.4
Suffer from ‘nerves’ 0.2 0.3 0.6 -0.6 0.2 -0.6 -0.8
Overall health rating 0.6 1.2 3.6 1.9 0.4 -1.0 0.4
Chest pain or discomfort 0.6 0.9 1.8 -1.3 0.2 -1.3 0.4
Had major operations 0.1 0.2 0.5 -0.0 0.7 0.0 0.4
Age at last live birth 0.0 0.1 0.2 -0.4 -0.2 -0.1 0.1
Family relationship satisfaction 1.4 1.8 3.1 0.8 1.8 1.2 -1.4
Leg pain on walking 1.2 1.5 5.5 2.3 -0.4 -0.7 -0.1
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 2.7 1.4 1.6 1.6 -0.1
Commuting to job workplace: Car/motor vehicle 1.3 1.5 5.4 2.3 -0.3 -0.1 0.7
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.9 -1.4 0.8 1.1 0.4
Medication: Aspirin 1.6 2.1 3.9 0.4 -2.0 -1.8 -1.1
Supplements: Vitamin C 0.1 0.1 0.3 -0.5 0.4 -0.4 0.2
Knee pain experienced in last month 0.7 1.1 2.2 1.5 0.4 -0.4 1.4
Hypertension (Self-reported) 1.6 4.5 9.1 -0.3 -3.0 -2.8 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.7 -0.1 0.2 -0.9 1.6
Illnesses of father: Heart disease 1.1 1.6 3.5 0.7 -1.4 -1.9 -0.7
Illnesses of siblings: Diabetes 0.7 0.9 1.6 0.8 -1.1 -1.3 0.4
Smoking status: Previous 2.0 3.0 5.2 0.4 -2.1 -2.3 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 2.6 -0.4 -0.9 -0.9 -1.6
Whole body fat-free mass 0.8 4.5 12.0 3.5 -1.4 -1.9 -0.9
Leg fat-free mass (right) 1.1 5.7 10.2 3.2 -2.1 -2.7 -0.9
Arm fat percentage (left) 1.8 7.1 17.1 4.1 -1.7 -2.8 -0.4
Average weekly red wine intake 0.5 0.7 1.0 0.0 1.0 1.0 0.9
Handedness (chirality/laterality): Left-handed 2.9 3.4 7.0 -0.2 2.6 1.8 1.8
Mood swings 0.4 0.7 1.8 -0.0 -0.1 -1.3 -1.0
Loneliness, isolation 1.8 2.5 3.6 1.8 -0.6 -1.7 -1.9
Long-standing illness, disability or infirmity 0.4 0.6 1.8 -0.0 -0.6 -1.4 -0.2
Ever had bowel cancer screening 0.3 0.4 1.3 0.3 -0.4 -0.2 1.1
Diabetes diagnosed by doctor 1.1 1.9 5.4 2.3 -1.0 -0.9 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 2.6 -1.6 -0.2 -1.0 -0.1
Friendships satisfaction 0.7 0.8 2.8 0.1 -0.1 -0.7 -1.7
Qualifications: nursing, teaching 0.2 0.2 0.7 -0.8 -0.2 0.3 0.4
Commuting to job workplace: Walk 1.5 1.6 6.1 -2.5 -0.4 -0.2 -0.1
Eye problems/disorders: Cataract 1.0 1.1 1.9 -0.0 -1.2 -1.1 -1.4
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.6 -1.9 -0.1 -0.2 -0.7
Medication for cholesterol 0.4 0.7 0.8 -0.9 0.9 0.6 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.3 -1.5 0.3 0.8 0.5
Back pain experienced in last month 1.4 2.0 5.0 0.2 -1.7 -2.2 0.3
Mineral and other dietary supplements 0.2 0.3 0.6 -0.4 0.1 0.5 -0.8
Breast cancer (self-reported) 0.6 0.7 1.6 0.5 0.5 0.7 -1.3
Asthma (self-reported) 0.2 0.5 1.0 -1.0 0.6 0.3 0.6
Osteoporosis (self-reported) 0.2 0.3 0.7 0.8 0.1 -0.0 -0.6
Osteoarthritis (self-reported) 1.0 1.3 4.1 2.0 0.2 -0.6 -0.8
Medication: Aspirin 1.0 1.4 2.3 -0.0 -1.5 -1.3 -1.2
Medication: Gliclazide 0.7 0.8 2.2 1.1 -0.2 -0.2 1.5
Illnesses of father: None of the above (group 1) 0.2 0.3 0.6 0.1 0.7 0.8 -0.3
Smoking status: Current 0.2 0.3 0.7 -0.6 0.8 -0.3 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.3 -0.6 -0.4 -0.1 0.5
Whole body water mass 0.8 4.6 11.9 3.5 -1.5 -1.9 -0.8
Leg predicted mass (right) 1.0 5.6 10.2 3.2 -2.1 -2.6 -0.9
Arm fat mass (left) 2.0 8.2 21.0 4.6 -1.8 -2.8 -0.6
Number of self-reported non-cancer illnesses 0.4 0.8 1.7 -0.3 -1.1 -1.3 -0.4
Average weekly champagne plus white wine intake 0.6 0.8 2.7 1.6 -0.2 -0.5 -0.6
Miserableness 0.4 0.6 1.1 -0.4 0.5 -1.0 -1.0
Guilty feelings 0.3 0.5 1.4 -1.2 -0.0 -0.5 -0.6
Wears glasses or contact lenses 1.4 1.6 3.0 0.5 -1.6 -1.7 -0.7
Ever taken oral contraceptive pill 0.5 0.6 1.7 -1.3 -0.2 -0.5 -0.5
Hearing aid user 1.8 2.1 3.4 -1.9 -1.8 -1.2 0.3
Mother’s age at death 0.5 0.6 1.6 0.8 -0.2 0.3 -1.3
Financial situation satisfaction 0.3 0.4 0.9 0.9 0.8 0.2 0.2
Tinnitus: Yes, now most or all of the time 1.7 1.9 4.5 2.1 0.6 0.8 -1.5
Commuting to job workplace: Public transport 0.9 1.0 2.1 -0.4 -1.0 -0.9 -1.5
Eye problems/disorders: Glaucoma 0.1 0.2 0.3 0.5 0.5 0.2 0.4
Medication: Blood pressure 1.0 1.9 4.7 0.8 -2.2 -1.5 0.2
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.3 -1.1 -0.2 -0.5 0.5
Supplements: Fish oil (including cod liver oil) 1.6 2.1 7.6 0.0 0.9 0.2 2.8
High cholesterol (Self-reported) 0.5 0.9 1.7 1.3 -0.6 -0.8 1.0
Medication: Bendroflumethiazide 0.2 0.3 0.5 0.4 -0.7 -0.4 -0.6
Medication: Paracetamol 0.2 0.3 0.7 0.1 -0.4 -0.9 -0.6
Medication: Lisinopril 0.6 0.8 2.8 0.3 0.4 0.0 1.7
Medication: Atorvastatin 0.8 0.9 1.1 0.9 -1.0 -0.9 1.1
Illnesses of father: High blood pressure 0.3 0.4 1.1 -1.0 -0.4 -0.4 -0.4
Alcohol drinker status: Never 0.1 0.1 0.4 -0.6 0.3 0.1 0.0
Ever smoked 1.1 1.9 3.2 -1.3 -0.5 -1.6 -1.8
Basal metabolic rate 1.0 5.5 15.2 3.9 -1.4 -2.0 -0.7
Leg fat percentage (left) 1.9 6.9 21.0 4.6 -1.0 -2.4 -0.0
Arm fat-free mass (left) 1.0 5.2 17.5 4.2 -0.9 -1.5 -0.6
Number of operations (self-reported) 0.4 0.6 1.2 1.1 -0.1 -1.0 0.4
Average weekly beer plus cider intake 3.0 4.3 10.0 1.2 -1.8 -1.7 -3.2
Irritability 0.6 1.0 2.0 -0.9 1.1 1.4 -0.1
Risk taking 3.7 5.5 7.6 -1.0 2.6 2.6 2.8
Ever had prostate specific antigen (PSA) test 1.6 1.8 3.0 0.9 -0.8 -1.6 -1.7
Fractured/broken bones in last 5 years 3.3 4.3 9.2 0.9 -2.2 -1.6 -3.0
Age started oral contraceptive pill 2.0 2.4 6.8 2.6 -1.2 -0.6 -1.0
Diastolic blood pressure, automated reading 1.0 3.0 7.2 2.7 -1.5 -1.3 -1.0
Ever depressed for a whole week 0.8 1.0 1.6 0.3 -0.9 -1.3 -1.2
Unable to work because of sickness or disability 0.9 1.2 3.0 -1.2 -0.6 -1.7 0.0
Commuting to job workplace: Cycle 1.4 1.7 3.0 -0.6 -1.3 -1.4 -1.7
Myopia 1.7 2.5 6.3 -0.9 -1.5 -0.7 -2.5
Vascular/heart problems diagnosed by doctor 1.1 2.9 6.1 0.4 2.5 2.4 -0.2
Cholesterol lowering medication 0.5 0.7 1.9 1.4 -0.6 -0.6 0.3
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 3.5 -0.3 -0.0 -0.8 1.9
Pain experienced in last month 0.9 1.4 4.8 -0.5 -0.4 0.7 -2.2
Supplements: Calcium 0.5 0.6 1.2 0.8 0.3 -0.5 -1.1
Basal cell carcinoma (self-reported) 0.2 0.2 0.4 0.6 0.4 0.2 -0.5
Heart attack/myocardial infarction (self-reported) 1.1 1.4 4.2 -0.9 0.5 0.6 2.0
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.6 0.8 0.1 0.2 -1.3
Heart disease (siblings) 2.3 2.8 4.1 1.2 -1.6 -2.0 -1.8
Alcohol drinker status: Previous 0.2 0.2 0.5 -0.4 -0.2 0.7 -0.2
Pack years of smoking 0.4 0.6 1.4 0.3 0.7 0.8 1.2
Impedance of whole body 0.6 2.9 4.5 -2.1 1.3 1.8 1.5
Leg fat mass (left) 2.2 8.7 26.3 5.1 -1.3 -2.6 -0.1
Arm predicted mass (left) 1.0 5.2 16.0 4.0 -1.2 -1.7 -0.9