Hub : Genes

GPR85

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0410	0.0180	3.5e-03	0.020	0.005	-0.002	0.005	0.005	1.6e-03	7.2e-02	7.2e-01	0.067	7.5e-02
2	TCGA	Breast Invasive Carcinoma	0.0581	0.0215	2.4e-10	0.018	0.056	0.046	NA	0.045	9.9e-05	1.6e-11	1.1e-09	NA	1.4e-09
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0265	0.0143	9.9e-03	0.007	0.008	0.001	NA	0.004	4.4e-02	3.5e-02	2.1e-01	NA	1.1e-01
4	TCGA	Testicular Germ Cell Tumors	0.1150	0.0620	5.8e-03	0.041	0.040	0.025	NA	0.055	1.4e-02	1.5e-02	4.5e-02	NA	5.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	2.5	4.0	7.8	-0.5	-1.9	-2.1	-2.8
Bipolar Disorder or Schizophrenia	0.9	2.1	5.2	-0.5	-1.0	-1.4	-2.3
Depressed Affect (Nagel 2018)	1.1	2.4	4.0	2.0	-0.3	-1.9	-1.4
Depression (Nagel 2018)	0.9	1.4	2.8	1.4	-0.8	-1.7	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.9	-0.4	-0.9	-0.6	-0.2
Neuroticism (Nagel 2018)	0.4	1.0	2.1	1.0	0.2	-0.8	-1.4
Schizophrenia (2018)	0.1	0.1	0.4	-0.2	0.2	-0.1	-0.7
Schizophrenia vs Biploar Disorder	1.5	2.0	4.1	0.1	2.0	1.9	0.6
Worry (Nagel 2018)	0.1	0.2	0.4	0.7	0.2	-0.2	-0.3
Alzheimer’s Disease (in mother)	0.6	0.7	2.8	0.3	-0.0	0.1	-1.7
Alzheimer’s Disease (in father)	0.3	0.4	0.6	-0.8	-0.1	0.5	-0.8
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.0	0.4	0.7	-0.4
Crohns Disease (2017)	0.6	1.4	3.7	-1.1	-0.5	-1.9	-0.7
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	0.1	0.2	-0.9	-0.7
Ulcerative Colitis (UC)	0.2	0.3	0.7	0.8	0.5	-0.0	-0.5
Major Depression (MDD)	2.2	2.7	5.3	0.2	-1.9	-1.3	-2.3
Reaction Time	0.2	0.3	0.9	-0.9	0.3	-0.3	0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.5	-0.6	-0.5	-0.7	-0.5
Breast Cancer	0.3	0.8	2.4	1.5	0.3	-0.1	0.8
Ovarian Cancer	0.9	1.2	3.1	-1.3	-0.1	0.2	1.8
Prostate Cancer	0.3	0.4	1.1	0.5	1.0	0.2	0.3
Age at First Birth	0.9	1.3	2.9	-0.2	1.7	1.4	-0.7
Bipolar Disorder (2011)	1.6	1.5	3.2	-0.8	-1.3	-0.7	-1.8
Body Mass Index (BMI) (2010)	1.7	2.3	4.5	2.1	1.2	1.1	1.4
Coronary Artery Disease (CAD)	1.3	1.5	4.0	2.0	0.8	-0.0	1.2
Crohns Disease (2012)	0.3	0.5	1.7	-0.4	-0.1	-1.3	-0.4
Mean Putamen Volume	0.4	0.5	1.0	-1.0	-0.4	-0.4	0.8
Fasting Glucose	0.7	0.8	1.5	0.8	1.0	1.2	-0.2
HbA1C	0.6	0.6	1.8	1.3	0.7	0.4	0.1
HDL Cholesterol	1.0	1.6	5.0	-2.2	-1.0	-0.1	-0.7
LDL Cholesterol	0.1	0.1	0.4	-0.0	-0.6	-0.4	-0.0
Lupus	0.4	0.7	1.5	-1.2	-0.1	-1.0	-0.4
Neuroticism (2016)	0.5	0.8	2.0	0.8	1.4	0.6	0.2
Primary Biliary Cirrhosis	1.0	1.4	3.7	0.3	-0.5	-1.2	-1.9
Rheumatoid Arthritis	0.1	0.2	0.6	0.0	-0.4	-0.8	0.1
Schizophrenia (2014)	0.2	0.4	0.9	-0.4	0.8	0.1	-1.0
Triglycerides	0.7	1.1	2.2	1.5	-0.7	-1.3	0.3
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.6	0.6	0.4	0.9	1.3
Ulcerative Colitis	0.2	0.3	0.6	-0.0	0.8	0.6	-0.4
Blood Eosinophil Count	1.0	8.1	15.8	-2.7	-1.4	-2.7	-4.0
Blood Platelet Count	0.0	0.3	0.7	0.3	-0.8	0.5	0.5
Blood Red Count	0.1	1.4	4.0	2.0	-0.7	-0.8	0.6
Blood White Count	0.2	1.4	3.4	0.6	-1.1	-1.8	-0.8
Heel T-Score	0.1	0.5	1.0	0.8	0.4	1.0	-0.3
BMI	1.4	8.2	27.7	5.3	-0.9	-2.0	0.4
Height	0.2	3.3	12.3	3.5	-0.8	-0.2	-0.5
Waist Hip Ratio (WHR)	0.2	1.0	2.2	-0.4	-1.2	-1.5	0.2
Systolic Blood Pressure	0.1	0.4	1.0	0.7	-0.4	-0.2	1.0
Smoking Status	0.9	2.1	5.1	-0.3	-1.2	-2.3	-1.4
Allergy or Eczema	1.1	3.0	6.0	-2.5	0.9	1.1	2.0
Cardiovascular Disease	0.5	1.8	3.3	0.5	-1.7	-1.8	0.8
Hypothyroidism (self reported)	0.3	0.7	2.2	-1.5	0.3	0.7	0.1
Respiratory disease	0.1	0.3	0.7	-0.2	0.8	0.7	0.0
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.3	1.5	-0.5	-0.9	1.1
Lung FEV1/FVC ratio	0.1	0.7	1.7	0.6	-0.8	-1.3	0.2
Lung FVC	0.2	1.0	2.6	-1.6	-0.9	-0.6	0.2
Neuroticism	0.5	1.1	2.3	0.7	-0.0	-1.3	-1.5
Chronotype (morning person)	0.3	0.7	2.3	-0.2	0.5	1.5	0.3
Hair Pigment	0.0	0.5	1.2	-0.7	-0.3	0.1	-1.1
Tanning	0.0	0.6	1.2	1.1	-0.4	-1.0	-0.2
Hand grip strength (left)	1.1	2.9	11.1	0.0	0.1	0.7	3.3
Number of treatments/medications taken	2.3	4.2	7.9	1.2	-2.7	-2.8	-0.5
Average weekly spirits intake	0.1	0.1	0.3	0.6	-0.1	0.0	-0.5
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.4	0.4	-0.0	-0.7
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.7	0.2	0.2	-0.8	0.4
Hearing difficulty/problems: Yes	0.6	0.9	3.4	-1.8	-0.1	0.0	-0.1
Relative age of first facial hair	0.4	0.8	1.7	1.3	-0.7	-0.2	0.9
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	4.1	0.6	-1.4	-2.0	-1.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.0	1.4	0.2	-0.4	-1.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	0.8	0.1	0.3	0.1
Systolic blood pressure, automated reading	0.6	1.8	3.7	1.9	-1.3	-1.1	-0.9
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.2	0.3	0.5	0.3
Angina	0.3	0.3	0.8	-0.5	0.5	0.4	0.9
Medication for hormone replacement therapy	1.3	1.5	3.4	-0.5	1.1	1.8	1.1
Vitamin and mineral supplements	0.9	1.2	4.5	0.3	-0.5	0.3	-2.1
Supplements: Zinc	2.4	2.6	6.4	-0.5	2.5	1.1	1.6
Medication: Co-codamol	0.2	0.3	0.5	-0.5	-0.6	-0.7	-0.1
Medication: Metformin	1.5	2.1	3.5	1.9	-1.5	-1.6	-0.0
Diabetes (father)	1.3	1.7	3.1	1.5	-0.7	-1.0	-1.8
Diabetes (mother)	1.1	1.4	3.3	1.0	-0.7	-1.8	-0.8
Severe depression (siblings)	0.4	0.5	1.4	-1.2	-0.0	0.7	0.1
Pack years adult smoking proportion	0.2	0.3	0.8	0.0	0.2	0.5	0.9
Impedance of leg (right)	1.0	4.9	8.7	-0.9	2.5	3.0	2.0
Leg fat-free mass (left)	1.1	5.6	12.5	3.5	-1.9	-2.3	-1.0
Trunk fat percentage	1.3	5.2	15.6	3.9	-1.1	-1.9	0.4
Hand grip strength (right)	0.7	1.8	5.7	0.3	0.6	1.0	2.4
Townsend deprivation index at recruitment	0.1	0.2	0.5	-0.7	-0.2	-0.4	0.0
Current tobacco smoking	0.2	0.3	0.7	-0.9	0.7	-0.3	-0.2
Average weekly fortified wine intake	0.9	1.0	2.1	-0.3	1.4	1.3	-0.4
Maternal smoking around birth	0.5	0.8	1.6	-0.1	-1.1	-1.3	-0.5
Fed-up feelings	0.2	0.3	0.8	-0.1	0.9	-0.4	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.6	0.6	-0.4	-1.3	0.6
Relative age voice broke	1.6	2.5	4.9	0.5	1.7	1.4	2.2
Taking other prescription medications	0.2	0.3	0.6	0.8	-0.2	-0.8	0.1
Age when periods started (menarche)	0.7	1.7	4.0	0.5	-2.0	-1.6	0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	0.6	0.7	0.2	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.3	-0.0	0.0	0.5	-0.0
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	5.9	-0.6	-1.3	-1.0	-2.4
Qualifications: CSEs or equivalent	1.2	1.5	5.2	-2.3	0.8	0.5	-0.0
Serious illness, injury or assault to yourself	0.4	0.5	1.0	0.8	-0.6	-1.0	-0.3
High blood pressure	1.4	3.8	7.8	-0.3	-2.8	-2.7	-0.4
Hayfever, allergic rhinitis or eczema	1.6	3.4	10.7	-3.3	0.5	0.9	1.3
Multivitamins +/- minerals	0.4	0.6	1.6	-0.4	0.0	-0.7	1.3
Stomach or abdominal pain in last month	1.2	1.5	4.6	-2.1	0.9	-0.2	0.7
Supplements: Glucosamine	1.1	1.4	3.1	0.8	-1.8	-1.2	-0.8
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.6	-0.1	-1.6	-1.6	-0.3
Medication: Atenolol	0.1	0.2	0.3	-0.1	-0.3	-0.6	0.5
Medication: Levothyroxine sodium	0.4	0.7	1.0	-1.0	0.8	0.9	0.5
Sitting height	0.1	0.7	1.2	0.5	-1.1	-0.7	-1.1
Chronic bronchitis/emphysema (father)	0.8	1.0	2.3	-0.6	1.0	0.4	1.5
High blood pressure (mother)	0.6	0.9	3.3	0.2	0.3	1.8	-0.1
Body mass index (BMI)	1.5	6.4	17.6	4.2	-1.4	-2.4	-0.7
Impedance of leg (left)	0.7	3.5	4.7	-1.0	2.0	2.2	2.1
Leg predicted mass (left)	1.0	5.6	12.5	3.5	-1.9	-2.3	-1.0
Trunk fat mass	1.6	7.0	21.0	4.6	-1.4	-2.2	0.1
Waist circumference	1.9	6.8	15.9	4.0	-1.4	-3.0	-0.6
Number of incorrect matches in round	0.4	0.6	1.4	-1.2	-0.1	0.9	-0.3
Past tobacco smoking	1.6	2.9	5.5	0.1	1.5	2.3	1.9
Alcohol usually taken with meals	0.4	0.7	1.4	-0.1	0.7	0.9	1.2
Nervous feelings	0.1	0.3	0.5	-0.6	0.2	-0.7	-0.4
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	6.6	-0.6	-1.4	-2.6	-2.2
Hearing difficulty/problems with background noise	1.0	1.6	6.0	-2.5	0.2	-0.3	0.5
Hair/balding pattern: Pattern 2	0.1	0.2	0.3	-0.1	-0.6	-0.3	-0.5
Had menopause	1.0	1.2	2.3	1.0	-0.7	-1.0	-1.5
Had other major operations	0.3	0.4	0.6	0.7	0.8	-0.6	0.2
Forced vital capacity (FVC)	0.2	0.8	2.5	-1.6	-0.4	-0.1	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.9	0.3	0.4	0.9	-0.0
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	3.8	1.1	-1.0	-1.9	-1.6
Qualifications: None of the above	0.9	1.9	3.4	1.8	-1.1	-1.6	-0.6
Financial difficulties in last 2 years	0.8	1.0	2.0	0.8	-0.8	-1.4	-0.9
Mouth/teeth dental problems	0.2	0.4	0.8	-0.2	-0.9	-0.2	-0.7
Heart attack	1.1	1.5	4.1	-1.0	0.6	0.6	2.0
Allergy	1.4	3.2	10.8	3.3	-0.7	-0.8	-0.9
Pain all over the body in last month	0.5	0.6	1.6	1.3	0.7	0.3	-0.1
Diabetes (self-reported)	0.9	1.5	3.3	1.8	-1.0	-1.0	-0.7
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	3.1	-1.8	0.8	1.1	0.8
Medication: Ramipril	2.7	3.5	5.4	0.4	-2.2	-2.3	-1.8
Medication: Simvastatin	0.3	0.5	1.1	0.8	-0.5	-1.0	-0.2
Fluid intelligence score	0.6	1.2	3.0	-0.1	-1.7	-1.0	-0.9
Illnesses of siblings	0.4	0.5	0.9	0.5	0.9	0.9	0.4
Neuroticism score	0.4	0.8	1.6	-0.4	0.4	-1.2	-1.1
Weight	1.5	7.6	22.4	4.7	-1.4	-2.4	-0.6
Impedance of arm (right)	0.3	1.6	3.6	-1.9	0.7	1.2	0.8
Arm fat percentage (right)	1.5	6.0	18.1	4.2	-1.0	-2.2	-0.2
Trunk fat-free mass	0.6	3.3	9.9	3.1	-1.0	-1.3	-0.8
Hip circumference	1.1	4.8	15.8	4.0	-0.4	-1.8	0.1
Time employed in main current job	0.5	0.5	0.7	-0.7	0.8	0.8	0.6
Alcohol intake versus 10 years previously	0.3	0.4	0.9	-0.4	-0.6	-0.9	0.5
Father’s age at death	0.2	0.3	0.7	-0.6	-0.0	0.8	0.4
Worrier / anxious feelings	0.5	1.0	3.0	-0.4	-0.6	-1.7	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.8	1.0	0.2	-1.3	-1.0
Falls in the last year	1.8	2.4	5.8	2.4	-0.6	-1.6	-0.9
Hair/balding pattern: Pattern 3	0.3	0.4	0.8	-0.9	0.6	0.2	0.7
Number of live births	1.4	2.0	4.8	-1.2	-1.3	-2.2	0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.6	-1.3	-0.3	0.1	0.5
Pulse rate	1.3	2.2	7.5	2.7	-0.6	-0.7	-0.6
Happiness	1.3	1.6	3.8	1.9	-0.2	-0.3	-1.6
Noisy workplace	0.4	0.5	1.1	0.6	-0.3	0.6	-1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.2	0.5	-0.6	-0.4	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.9	-0.4	-0.7	-1.4	0.6
Mouth/teeth dental problems: Dentures	0.3	0.5	1.2	1.1	-0.1	-0.5	-0.7
Asthma	0.2	0.4	1.2	-1.1	0.3	0.1	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.0	0.5	-0.0	-0.0	1.0
Medication: Cholesterol lowering	0.5	0.8	1.5	-0.4	-1.2	-1.2	-0.3
Depression (self-reported)	0.4	0.4	1.5	-1.2	0.3	-0.5	-0.1
Medication: Lansoprazole	2.1	2.3	4.4	1.7	-0.4	-1.4	2.1
Prospective memory result	3.5	4.4	8.9	0.8	1.7	2.2	3.0
Lung cancer (father)	2.2	2.5	5.4	0.1	1.5	1.6	2.3
Illnesses of mother	1.5	1.8	4.3	-1.3	1.1	0.4	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.6	-0.8	-0.7	-0.1	0.2
Pulse wave Arterial Stiffness index	0.5	0.6	1.0	1.0	0.6	0.7	0.6
Impedance of arm (left)	0.3	1.4	4.9	-2.2	-0.1	0.4	0.8
Arm fat mass (right)	1.7	7.0	21.7	4.7	-1.2	-2.2	-0.3
Trunk predicted mass	0.6	3.5	10.3	3.2	-1.0	-1.4	-0.9
Standing height	0.1	0.9	3.0	1.7	-0.5	-0.4	-0.2
Length of working week for main job	1.2	1.3	2.6	1.6	0.9	1.4	0.0
Exposure to tobacco smoke at home	0.4	0.5	1.1	-0.3	0.6	1.1	-0.4
Breastfed as a baby	0.6	0.7	1.1	-0.8	0.6	1.0	0.9
Tense / ‘highly strung’	0.2	0.4	0.6	-0.8	0.7	0.4	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	4.3	0.1	-1.6	-2.1	-1.0
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	0.1	0.6	1.1	-0.3
Birth weight of first child	0.1	0.2	0.6	0.7	-0.4	0.4	-0.4
Peak expiratory flow (PEF)	0.2	0.5	1.7	-1.3	0.3	0.3	0.5
Pulse wave reflection index	0.1	0.1	0.3	-0.1	0.2	0.6	-0.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.5	1.9	-0.3	-0.2	-1.1
Loud music exposure frequency	4.3	4.7	14.5	-0.1	-1.6	-1.3	-3.8
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	-0.0	0.8	-0.0	0.5
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.7	-0.2	-0.1	-0.6	2.2
Blood clot in the leg (DVT)	0.5	0.6	1.6	0.9	0.0	0.2	-1.3
Medication: Paracetamol	0.7	1.1	1.8	0.6	-0.8	-1.3	-1.2
Headache pain in last month	0.5	0.9	1.9	-0.1	-0.4	-1.4	1.2
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	4.6	0.5	2.1	2.1	-0.2
Glaucoma (self-reported)	0.4	0.4	1.0	0.4	1.0	0.6	0.5
Gout (self-reported)	0.1	0.2	0.5	-0.4	0.1	0.7	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.2	-1.1	-0.2	0.2	-0.3
Medication: Amlodipine	1.8	2.5	5.9	-0.9	-2.4	-1.8	-0.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	-1.0	-0.6	-0.5	-0.1
Birth weight	0.2	0.4	0.7	0.6	-0.8	-0.4	0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.1	-0.3	-0.6	0.5
High blood pressure (siblings)	0.5	0.7	2.6	-1.6	-0.4	-0.0	0.3
Forced vital capacity (FVC), Best measure	0.1	0.3	0.8	-0.9	-0.6	0.0	0.5
Body fat percentage	1.5	6.1	19.1	4.4	-0.9	-2.0	0.4
Leg fat percentage (right)	1.6	5.8	19.8	4.4	-0.6	-1.8	-0.0
Arm fat-free mass (right)	0.8	4.1	12.1	3.5	-1.2	-1.7	-0.5
Exposure to tobacco smoke outside home	3.3	4.5	6.7	0.3	2.5	2.6	2.1
Comparative body size at age 10	0.3	0.7	2.6	0.6	0.1	-0.1	1.6
Number of full brothers	1.5	1.9	3.8	-0.3	-1.6	-1.9	-1.0
Worry too long after embarrassment	0.9	1.5	3.8	-1.2	0.1	-0.9	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.1	-0.1	-0.4	-0.6
Wheeze or whistling in the chest in last year	0.4	0.6	2.2	-1.5	0.6	-0.3	-0.2
Number of children fathered	0.4	0.5	0.8	-0.1	0.9	0.5	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.8	2.0	-1.4	-0.3	0.8	-0.5
Age at first live birth	0.4	0.7	1.2	1.0	-1.1	-0.4	-0.8
Pulse wave peak to peak time	0.4	0.5	0.7	-0.8	-0.6	-0.8	-0.7
Health satisfaction	0.8	1.0	3.7	1.9	0.6	-0.2	-0.2
Shortness of breath walking on level ground	0.5	0.6	0.9	0.9	0.8	-0.4	0.9
Qualifications: College or University degree	0.7	2.1	5.4	-2.3	-0.6	0.1	-1.6
Eye problems/disorders: None of the above	1.6	1.9	2.8	0.5	1.7	1.5	1.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.1	0.6	0.5	0.1
Emphysema/chronic bronchitis	1.0	1.1	1.9	-0.9	1.3	0.3	-1.4
Medication for pain relief, constipation, heartburn	1.6	2.7	5.1	-1.1	2.0	2.3	0.5
Neck or shoulder pain in last month	2.7	3.8	14.2	-0.3	1.0	-0.1	3.8
Medication: Blood pressure	0.9	1.7	4.0	-0.2	-2.0	-1.6	-0.3
Angina (self-reported)	0.2	0.3	0.5	-0.6	0.4	0.2	0.7
Migraine (self-reported)	0.1	0.2	0.3	-0.6	0.4	-0.0	0.4
Medication: Ibuprofen	0.0	0.1	0.1	0.4	0.1	0.1	0.3
Medication: Allopurinol	0.3	0.4	0.9	-0.5	-0.8	-0.9	-0.0
Medication: Omeprazole	1.0	1.1	3.9	-0.7	0.1	-0.5	2.0
Medication: Seretide 50 evohaler	0.4	0.5	1.3	-0.4	-0.4	-0.5	-1.1
Mean time to correctly identify matches	0.4	0.7	1.3	0.1	-0.7	-1.1	-1.0
Heart disease (mother)	2.6	3.2	6.8	-0.6	-1.7	-1.6	-2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	-1.0	-0.7	-0.6	-0.7
Whole body fat mass	1.9	8.1	25.1	5.0	-1.2	-2.4	0.1
Leg fat mass (right)	2.1	8.2	26.2	5.1	-1.1	-2.3	-0.1
Arm predicted mass (right)	0.9	4.8	13.2	3.6	-1.5	-1.8	-0.9
Pulse rate, automated reading	0.7	2.3	4.3	2.1	-1.4	-1.4	-0.9
Alcohol intake frequency.	0.7	1.6	3.5	0.5	-1.4	-1.9	-1.0
Comparative height size at age 10	0.2	0.8	1.8	1.3	-0.4	-0.6	-1.1
Number of full sisters	1.7	2.1	4.0	-0.2	-1.5	-2.0	-1.4
Suffer from ‘nerves’	0.2	0.3	0.6	-0.6	0.2	-0.6	-0.8
Overall health rating	0.6	1.2	3.6	1.9	0.4	-1.0	0.4
Chest pain or discomfort	0.6	0.9	1.8	-1.3	0.2	-1.3	0.4
Had major operations	0.1	0.2	0.5	-0.0	0.7	0.0	0.4
Age at last live birth	0.0	0.1	0.2	-0.4	-0.2	-0.1	0.1
Family relationship satisfaction	1.4	1.8	3.1	0.8	1.8	1.2	-1.4
Leg pain on walking	1.2	1.5	5.5	2.3	-0.4	-0.7	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	2.7	1.4	1.6	1.6	-0.1
Commuting to job workplace: Car/motor vehicle	1.3	1.5	5.4	2.3	-0.3	-0.1	0.7
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.9	-1.4	0.8	1.1	0.4
Medication: Aspirin	1.6	2.1	3.9	0.4	-2.0	-1.8	-1.1
Supplements: Vitamin C	0.1	0.1	0.3	-0.5	0.4	-0.4	0.2
Knee pain experienced in last month	0.7	1.1	2.2	1.5	0.4	-0.4	1.4
Hypertension (Self-reported)	1.6	4.5	9.1	-0.3	-3.0	-2.8	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.7	-0.1	0.2	-0.9	1.6
Illnesses of father: Heart disease	1.1	1.6	3.5	0.7	-1.4	-1.9	-0.7
Illnesses of siblings: Diabetes	0.7	0.9	1.6	0.8	-1.1	-1.3	0.4
Smoking status: Previous	2.0	3.0	5.2	0.4	-2.1	-2.3	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.6	-0.4	-0.9	-0.9	-1.6
Whole body fat-free mass	0.8	4.5	12.0	3.5	-1.4	-1.9	-0.9
Leg fat-free mass (right)	1.1	5.7	10.2	3.2	-2.1	-2.7	-0.9
Arm fat percentage (left)	1.8	7.1	17.1	4.1	-1.7	-2.8	-0.4
Average weekly red wine intake	0.5	0.7	1.0	0.0	1.0	1.0	0.9
Handedness (chirality/laterality): Left-handed	2.9	3.4	7.0	-0.2	2.6	1.8	1.8
Mood swings	0.4	0.7	1.8	-0.0	-0.1	-1.3	-1.0
Loneliness, isolation	1.8	2.5	3.6	1.8	-0.6	-1.7	-1.9
Long-standing illness, disability or infirmity	0.4	0.6	1.8	-0.0	-0.6	-1.4	-0.2
Ever had bowel cancer screening	0.3	0.4	1.3	0.3	-0.4	-0.2	1.1
Diabetes diagnosed by doctor	1.1	1.9	5.4	2.3	-1.0	-0.9	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.6	-1.6	-0.2	-1.0	-0.1
Friendships satisfaction	0.7	0.8	2.8	0.1	-0.1	-0.7	-1.7
Qualifications: nursing, teaching	0.2	0.2	0.7	-0.8	-0.2	0.3	0.4
Commuting to job workplace: Walk	1.5	1.6	6.1	-2.5	-0.4	-0.2	-0.1
Eye problems/disorders: Cataract	1.0	1.1	1.9	-0.0	-1.2	-1.1	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.6	-1.9	-0.1	-0.2	-0.7
Medication for cholesterol	0.4	0.7	0.8	-0.9	0.9	0.6	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.3	-1.5	0.3	0.8	0.5
Back pain experienced in last month	1.4	2.0	5.0	0.2	-1.7	-2.2	0.3
Mineral and other dietary supplements	0.2	0.3	0.6	-0.4	0.1	0.5	-0.8
Breast cancer (self-reported)	0.6	0.7	1.6	0.5	0.5	0.7	-1.3
Asthma (self-reported)	0.2	0.5	1.0	-1.0	0.6	0.3	0.6
Osteoporosis (self-reported)	0.2	0.3	0.7	0.8	0.1	-0.0	-0.6
Osteoarthritis (self-reported)	1.0	1.3	4.1	2.0	0.2	-0.6	-0.8
Medication: Aspirin	1.0	1.4	2.3	-0.0	-1.5	-1.3	-1.2
Medication: Gliclazide	0.7	0.8	2.2	1.1	-0.2	-0.2	1.5
Illnesses of father: None of the above (group 1)	0.2	0.3	0.6	0.1	0.7	0.8	-0.3
Smoking status: Current	0.2	0.3	0.7	-0.6	0.8	-0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	-0.6	-0.4	-0.1	0.5
Whole body water mass	0.8	4.6	11.9	3.5	-1.5	-1.9	-0.8
Leg predicted mass (right)	1.0	5.6	10.2	3.2	-2.1	-2.6	-0.9
Arm fat mass (left)	2.0	8.2	21.0	4.6	-1.8	-2.8	-0.6
Number of self-reported non-cancer illnesses	0.4	0.8	1.7	-0.3	-1.1	-1.3	-0.4
Average weekly champagne plus white wine intake	0.6	0.8	2.7	1.6	-0.2	-0.5	-0.6
Miserableness	0.4	0.6	1.1	-0.4	0.5	-1.0	-1.0
Guilty feelings	0.3	0.5	1.4	-1.2	-0.0	-0.5	-0.6
Wears glasses or contact lenses	1.4	1.6	3.0	0.5	-1.6	-1.7	-0.7
Ever taken oral contraceptive pill	0.5	0.6	1.7	-1.3	-0.2	-0.5	-0.5
Hearing aid user	1.8	2.1	3.4	-1.9	-1.8	-1.2	0.3
Mother’s age at death	0.5	0.6	1.6	0.8	-0.2	0.3	-1.3
Financial situation satisfaction	0.3	0.4	0.9	0.9	0.8	0.2	0.2
Tinnitus: Yes, now most or all of the time	1.7	1.9	4.5	2.1	0.6	0.8	-1.5
Commuting to job workplace: Public transport	0.9	1.0	2.1	-0.4	-1.0	-0.9	-1.5
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	0.5	0.5	0.2	0.4
Medication: Blood pressure	1.0	1.9	4.7	0.8	-2.2	-1.5	0.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.3	-1.1	-0.2	-0.5	0.5
Supplements: Fish oil (including cod liver oil)	1.6	2.1	7.6	0.0	0.9	0.2	2.8
High cholesterol (Self-reported)	0.5	0.9	1.7	1.3	-0.6	-0.8	1.0
Medication: Bendroflumethiazide	0.2	0.3	0.5	0.4	-0.7	-0.4	-0.6
Medication: Paracetamol	0.2	0.3	0.7	0.1	-0.4	-0.9	-0.6
Medication: Lisinopril	0.6	0.8	2.8	0.3	0.4	0.0	1.7
Medication: Atorvastatin	0.8	0.9	1.1	0.9	-1.0	-0.9	1.1
Illnesses of father: High blood pressure	0.3	0.4	1.1	-1.0	-0.4	-0.4	-0.4
Alcohol drinker status: Never	0.1	0.1	0.4	-0.6	0.3	0.1	0.0
Ever smoked	1.1	1.9	3.2	-1.3	-0.5	-1.6	-1.8
Basal metabolic rate	1.0	5.5	15.2	3.9	-1.4	-2.0	-0.7
Leg fat percentage (left)	1.9	6.9	21.0	4.6	-1.0	-2.4	-0.0
Arm fat-free mass (left)	1.0	5.2	17.5	4.2	-0.9	-1.5	-0.6
Number of operations (self-reported)	0.4	0.6	1.2	1.1	-0.1	-1.0	0.4
Average weekly beer plus cider intake	3.0	4.3	10.0	1.2	-1.8	-1.7	-3.2
Irritability	0.6	1.0	2.0	-0.9	1.1	1.4	-0.1
Risk taking	3.7	5.5	7.6	-1.0	2.6	2.6	2.8
Ever had prostate specific antigen (PSA) test	1.6	1.8	3.0	0.9	-0.8	-1.6	-1.7
Fractured/broken bones in last 5 years	3.3	4.3	9.2	0.9	-2.2	-1.6	-3.0
Age started oral contraceptive pill	2.0	2.4	6.8	2.6	-1.2	-0.6	-1.0
Diastolic blood pressure, automated reading	1.0	3.0	7.2	2.7	-1.5	-1.3	-1.0
Ever depressed for a whole week	0.8	1.0	1.6	0.3	-0.9	-1.3	-1.2
Unable to work because of sickness or disability	0.9	1.2	3.0	-1.2	-0.6	-1.7	0.0
Commuting to job workplace: Cycle	1.4	1.7	3.0	-0.6	-1.3	-1.4	-1.7
Myopia	1.7	2.5	6.3	-0.9	-1.5	-0.7	-2.5
Vascular/heart problems diagnosed by doctor	1.1	2.9	6.1	0.4	2.5	2.4	-0.2
Cholesterol lowering medication	0.5	0.7	1.9	1.4	-0.6	-0.6	0.3
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.5	-0.3	-0.0	-0.8	1.9
Pain experienced in last month	0.9	1.4	4.8	-0.5	-0.4	0.7	-2.2
Supplements: Calcium	0.5	0.6	1.2	0.8	0.3	-0.5	-1.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.6	0.4	0.2	-0.5
Heart attack/myocardial infarction (self-reported)	1.1	1.4	4.2	-0.9	0.5	0.6	2.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.6	0.8	0.1	0.2	-1.3
Heart disease (siblings)	2.3	2.8	4.1	1.2	-1.6	-2.0	-1.8
Alcohol drinker status: Previous	0.2	0.2	0.5	-0.4	-0.2	0.7	-0.2
Pack years of smoking	0.4	0.6	1.4	0.3	0.7	0.8	1.2
Impedance of whole body	0.6	2.9	4.5	-2.1	1.3	1.8	1.5
Leg fat mass (left)	2.2	8.7	26.3	5.1	-1.3	-2.6	-0.1
Arm predicted mass (left)	1.0	5.2	16.0	4.0	-1.2	-1.7	-0.9