TWAS hub - GPR98

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0840	0.0240	2.0e-06	0.070	0.063	0.035	0.063	0.051	6.8e-09	3.5e-08	3.5e-05	3.7e-08	7.3e-07
2	ROSMAP	Brain Pre-frontal Cortex	0.0886	0.0283	7.5e-05	0.041	0.036	0.049	0.042	0.040	4.7e-06	1.5e-05	5.5e-07	4.1e-06	5.7e-06
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.1344	0.0549	8.8e-03	0.033	0.009	0.020	NA	0.013	1.2e-04	3.3e-02	2.2e-03	NA	1.0e-02
4	TCGA	Thyroid Carcinoma	0.0810	0.0370	2.0e-03	0.003	0.024	0.004	NA	0.007	1.7e-01	2.1e-03	1.2e-01	NA	6.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Happiness	3.9	4.8	7.9	-2.8	-1.6	1.1	-2.8
Worry too long after embarrassment	3.5	5.9	11.6	-2.2	-2.6	0.6	-3.4
Alzheimer’s Disease (in mother)	3.4	4.0	6.1	2.3	2.5	1.4	1.6
Triglycerides	3.3	5.4	10.3	3.0	1.3	-1.0	3.2
Mother’s age at death	3.3	4.2	6.4	-1.3	-1.8	2.2	-2.5
Rheumatoid Arthritis	3.2	4.5	9.8	-3.1	-1.6	-0.4	-2.3
Pain type(s) experienced in last month: Hip pain	3.2	4.1	7.9	1.0	2.8	-1.1	2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.0	3.5	5.4	2.3	2.3	0.4	1.7
Medication: Ibuprofen (e.g. Nurofen)	2.9	3.6	11.7	0.9	3.4	1.4	0.2
Medication: Ibuprofen	2.9	3.5	11.1	0.2	3.3	1.6	0.0
Intelligence (Savage-Jansen 2018)	2.6	8.1	16.6	4.1	2.5	-0.7	3.0
Type 2 Diabetes (T2D) (2018)	2.6	4.8	9.1	2.3	2.1	-0.7	3.0
Lung cancer (father)	2.6	3.1	6.1	2.5	1.3	-1.5	1.5
Mean Putamen Volume	2.5	2.8	6.1	2.5	0.1	0.9	2.1
Birth weight of first child	2.5	4.5	8.2	2.5	1.5	-1.1	2.9
Schizophrenia (2018)	2.4	4.9	6.2	-1.8	-2.4	2.5	-2.2
HDL Cholesterol	2.4	3.9	8.0	-2.2	-1.6	-0.6	-2.8
Wears glasses or contact lenses	2.3	2.7	7.0	-1.7	-0.9	-0.3	-2.6
Neuroticism	2.2	5.2	12.4	-3.5	-1.0	0.4	-2.7
Diabetes (self-reported)	2.2	3.4	8.2	1.4	1.8	0.1	2.9
Asthma (self-reported)	2.2	4.5	8.2	2.4	1.9	0.4	2.9
Primary Biliary Cirrhosis	2.1	2.9	7.4	-1.5	-2.7	-1.4	-0.5
Worrier / anxious feelings	2.1	3.9	6.3	-2.5	-2.4	0.1	-1.9
Falls in the last year	2.1	2.9	5.0	1.4	2.2	-1.4	1.6
Number of live births	2.1	3.0	5.4	2.0	2.3	-0.4	1.6
Friendships satisfaction	2.1	2.6	6.9	-1.1	0.3	2.6	-1.5
Bipolar Disorder or Schizophrenia	2.0	4.9	5.9	-2.0	-2.4	2.1	-2.3
Alzheimer’s Disease (including proxy)	2.0	2.9	4.9	1.6	2.2	1.9	0.8
Schizophrenia (2014)	2.0	4.3	7.8	-1.6	-2.8	1.8	-2.0
Age when periods started (menarche)	2.0	4.9	9.3	-2.9	-1.4	-0.0	-3.0
Neuroticism score	2.0	4.1	9.3	-3.1	-1.2	0.1	-2.4
Age at First Birth	1.9	2.8	8.1	0.7	1.4	0.8	2.8
Chronotype (morning person)	1.9	4.5	9.8	3.1	1.0	0.7	2.6
Hair/balding pattern: Pattern 4	1.9	4.7	11.7	0.9	3.4	0.6	2.5
Mouth/teeth dental problems: Loose teeth	1.9	2.2	4.8	1.6	1.1	0.7	2.2
Family relationship satisfaction	1.9	2.3	4.0	-1.8	0.1	1.5	-2.0
Major Depression (MDD)	1.8	2.1	3.1	-1.5	-1.0	1.4	-1.8
Waist circumference	1.8	6.5	9.2	2.8	3.0	0.2	3.0
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	3.9	1.7	1.2	-1.1	2.0
Exposure to tobacco smoke at home	1.8	2.0	7.5	-2.7	-0.4	0.3	-0.6
Leg fat percentage (right)	1.8	6.6	9.2	2.8	2.8	-1.2	3.0
Age at last live birth	1.8	2.6	4.1	2.0	1.6	1.5	1.1
High cholesterol (Self-reported)	1.8	3.2	5.6	2.4	1.8	-0.1	2.0
Schizophrenia vs Biploar Disorder	1.7	2.2	4.7	1.2	1.0	2.2	1.4
Ovarian Cancer	1.7	2.3	4.0	-1.7	-1.3	0.8	-2.0
Neuroticism (2016)	1.7	2.5	4.1	-2.0	-1.2	0.7	-2.0
Asthma	1.7	3.4	6.4	2.2	1.5	0.5	2.5
Leg fat percentage (left)	1.7	6.2	8.7	2.8	2.7	-1.1	3.0
Nervous feelings	1.6	3.0	8.6	-2.9	-0.8	-0.7	-1.5
Had other major operations	1.6	2.0	5.9	0.5	-0.7	-2.4	1.1
Guilty feelings	1.6	2.3	6.3	-2.5	-0.7	0.3	-1.6
Depression (Nagel 2018)	1.5	2.2	5.0	-2.2	1.2	-1.4	-0.6
Neuroticism (Nagel 2018)	1.5	3.4	7.3	-2.7	-0.6	1.2	-2.1
Worry (Nagel 2018)	1.5	3.3	9.0	-3.0	-1.3	0.6	-1.5
Mouth/teeth dental problems	1.5	2.3	4.4	-1.7	-1.4	0.3	-2.1
Prospective memory result	1.5	1.9	3.7	-1.9	0.6	1.8	-0.4
Tinnitus: Yes, now most or all of the time	1.5	1.7	3.5	-1.7	-0.6	0.3	-1.9
Number of operations (self-reported)	1.5	2.2	3.4	1.9	1.1	-1.6	1.3
Prostate Cancer	1.4	2.0	4.9	1.2	1.3	-2.2	0.1
Medication: Co-codamol	1.4	1.6	5.2	-0.7	0.3	-2.3	-0.9
Hearing difficulty/problems with background noise	1.4	2.2	6.8	-2.6	-0.0	-0.4	-1.4
Illnesses of mother	1.4	1.7	3.8	-1.4	-0.8	-0.8	-1.9
High blood pressure (siblings)	1.4	2.0	4.1	-0.5	-2.0	-0.4	-1.9
Health satisfaction	1.4	1.8	4.0	-1.6	-0.7	-0.2	-2.0
Ulcerative Colitis (UC)	1.3	2.5	5.6	-2.4	-1.0	-1.0	-1.5
Hearing difficulty/problems: Yes	1.3	2.0	4.2	-2.1	-0.0	-0.9	-1.7
Townsend deprivation index at recruitment	1.3	1.8	5.2	0.7	2.3	1.1	0.6
Body mass index (BMI)	1.3	5.7	8.5	2.9	2.6	-1.0	2.6
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	2.8	-1.7	-1.1	1.1	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.4	3.0	1.7	-0.0	-0.4	1.6
Length of working week for main job	1.3	1.4	2.6	-0.6	-1.6	0.2	-1.6
Neck or shoulder pain in last month	1.3	1.9	4.3	-2.1	0.8	-0.2	-1.6
Bipolar Disorder (2011)	1.2	1.2	2.1	-0.3	-1.2	-1.4	-1.0
Waist Hip Ratio (WHR)	1.2	5.3	10.4	1.2	3.0	-0.3	3.2
Hypothyroidism (self reported)	1.2	2.7	7.6	1.2	0.8	-2.8	1.1
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.5	-1.9	1.5	-0.7	-0.9
Alcohol usually taken with meals	1.2	2.0	4.2	1.3	-1.2	-2.0	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	3.5	-1.5	-1.2	-1.9	-0.6
Medication: Omeprazole	1.2	1.5	3.9	0.7	2.0	0.2	1.2
Leg fat mass (right)	1.2	4.5	7.0	2.6	2.3	-0.6	2.3
Supplements: Vitamin C	1.2	1.5	2.7	-1.1	-1.6	-0.9	-1.1
Medication: Blood pressure	1.2	2.3	4.8	-0.3	-2.2	0.8	-1.9
Unable to work because of sickness or disability	1.2	1.6	4.1	1.0	2.0	0.7	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	3.2	-1.8	1.0	-1.2	0.1
Serious illness, injury or assault to yourself	1.1	1.4	3.2	-1.3	-0.7	-1.8	-0.2
Hair/balding pattern: Pattern 2	1.1	1.5	2.9	0.5	-1.7	-1.5	-0.5
Arm fat percentage (right)	1.1	4.2	5.7	2.3	2.4	-0.2	2.4
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	5.4	1.2	1.2	-2.3	0.5
Body fat percentage	1.1	4.4	6.2	2.3	2.4	0.0	2.5
Migraine (self-reported)	1.1	1.4	2.6	-1.6	-1.4	0.2	-1.0
Number of full sisters	1.1	1.3	3.2	0.6	1.8	-0.3	1.2
Mood swings	1.1	2.0	3.8	-1.9	0.7	0.4	-1.9
Diabetes diagnosed by doctor	1.1	1.8	3.7	1.1	1.4	0.5	1.9
Hearing aid user	1.1	1.2	2.2	-1.5	-0.0	1.1	-1.2
Illnesses of father: High blood pressure	1.1	1.4	2.7	-1.6	-1.4	0.4	-1.0
Myopia	1.1	1.6	3.0	1.7	0.2	-0.7	1.7
Leg fat mass (left)	1.1	4.1	6.7	2.6	2.1	-0.4	2.2
Ulcerative Colitis	1.0	1.4	2.3	-1.1	-1.3	-1.5	-0.7
Ever used hormone-replacement therapy (HRT)	1.0	1.3	4.8	-2.2	0.4	-0.5	0.3
Trunk fat percentage	1.0	3.9	5.5	2.1	2.3	0.3	2.3
High blood pressure	1.0	2.7	6.9	-0.3	-1.4	1.4	-2.6
Medication: Levothyroxine sodium	1.0	1.7	3.1	1.4	1.8	-1.1	0.6
Illnesses of siblings	1.0	1.4	2.6	0.9	1.3	0.7	1.6
Time employed in main current job	1.0	1.1	2.3	-1.2	-1.5	-0.7	-0.3
Pulse wave reflection index	1.0	1.2	3.6	-0.2	0.7	0.9	1.9
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.6	1.6	0.2	-1.2	1.1
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.9	1.7	0.5	-1.2	0.8
Comparative body size at age 10	1.0	2.8	7.4	2.7	1.4	0.7	1.1
Medication for pain relief, constipation, heartburn	1.0	1.8	5.8	-0.6	-2.4	-0.7	-0.6
Hypertension (Self-reported)	1.0	2.8	7.3	-0.0	-1.4	1.4	-2.7
Long-standing illness, disability or infirmity	1.0	1.5	2.4	-0.9	-0.8	-1.5	-1.6
Financial situation satisfaction	1.0	1.2	3.6	-0.8	1.9	0.7	0.5
Hair Pigment	0.9	25.7	82.1	-3.0	-1.3	-3.2	-9.1
Medication: Metformin	0.9	1.3	1.7	1.3	1.0	1.0	1.1
Financial difficulties in last 2 years	0.9	1.2	2.2	0.6	1.5	-1.4	0.6
Medication: Ramipril	0.9	1.2	2.5	1.3	0.7	1.6	0.2
Noisy workplace	0.9	1.1	2.5	-0.1	1.6	-1.3	0.5
Arm fat mass (right)	0.9	3.6	5.3	2.3	2.1	-0.2	2.1
Tense / ‘highly strung’	0.9	1.5	4.3	-1.3	-0.3	0.3	-2.1
Birth weight	0.9	1.9	3.8	0.6	-0.9	-1.9	1.6
Forced vital capacity (FVC), Best measure	0.9	3.1	5.5	-2.3	-1.6	1.4	-1.6
Number of children fathered	0.9	1.0	2.2	-0.8	-0.8	0.8	-1.5
Whole body fat mass	0.9	3.7	6.0	2.5	2.1	0.2	2.0
Eye problems/disorders: Cataract	0.9	1.1	1.7	1.3	1.2	-0.5	1.0
Medication for cholesterol	0.9	1.4	3.0	0.8	1.7	-0.2	1.4
Ever taken oral contraceptive pill	0.9	1.0	2.2	1.5	1.1	0.5	0.6
Medication: Bendroflumethiazide	0.9	1.3	2.1	0.7	-1.4	1.0	-1.3
Commuting to job workplace: Cycle	0.9	1.1	3.4	-0.9	-1.9	-0.4	-0.1
Vascular/heart problems diagnosed by doctor	0.9	2.5	5.5	0.2	1.4	-1.5	2.4
Alzheimer’s Disease (in father)	0.8	0.9	2.1	-0.7	-0.2	1.5	-0.9
Verbal and Numeric Reasoning (VNR)	0.8	2.0	4.8	2.2	1.2	-1.0	0.8
Breast Cancer	0.8	2.0	3.0	-0.5	1.4	1.7	1.6
Blood Platelet Count	0.8	9.1	27.1	2.6	0.0	1.6	5.2
Respiratory disease	0.8	1.8	3.3	1.3	1.4	0.0	1.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	1.6	-1.2	-0.8	-1.0	-0.9
Diabetes (father)	0.8	1.0	1.9	1.4	0.5	0.6	1.2
Fed-up feelings	0.8	1.5	4.4	-1.0	2.1	0.7	0.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.2	0.3	1.5	-1.0	-0.3
Medication: Atenolol	0.8	1.0	1.9	1.1	-1.4	1.0	0.1
Pain all over the body in last month	0.8	0.8	2.7	-0.3	-1.6	0.1	-0.7
Pulse wave Arterial Stiffness index	0.8	0.9	1.3	-1.1	1.2	0.9	0.6
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.2	0.2	1.5	-0.8	0.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.2	2.3	-1.5	-0.8	-1.4	-0.1
Pulse wave peak to peak time	0.8	1.0	1.6	1.0	-1.3	-0.8	-0.8
Leg pain on walking	0.8	0.9	3.1	-1.8	-0.7	-0.5	-0.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	3.2	0.2	-0.6	1.8	0.5
Smoking status: Previous	0.8	1.1	3.7	1.9	-0.4	0.8	-0.2
Arm fat percentage (left)	0.8	3.4	4.5	2.1	2.1	-0.4	2.1
Irritability	0.8	1.4	4.8	-0.9	-0.1	-0.2	-2.2
Lupus	0.7	1.1	2.7	-1.2	-0.4	1.6	0.1
BMI	0.7	4.3	6.9	2.5	2.6	-0.5	1.9
Vitamin and mineral supplements	0.7	0.9	2.0	0.1	1.4	1.2	0.4
Supplements: Zinc	0.7	0.8	1.3	1.1	-1.1	-0.1	0.8
Taking other prescription medications	0.7	1.1	3.6	0.3	1.9	-0.2	0.8
Chronic bronchitis/emphysema (father)	0.7	0.8	2.7	0.1	1.6	0.6	0.6
Trunk fat mass	0.7	3.0	4.4	2.1	2.0	0.4	1.9
Past tobacco smoking	0.7	1.2	4.5	-2.1	0.3	-0.2	-0.5
Qualifications: None of the above	0.7	1.5	4.4	0.8	0.8	-0.6	2.1
Heart attack	0.7	0.9	2.2	0.8	-1.5	0.9	-0.3
Qualifications: A levels/AS levels or equivalent	0.7	1.6	3.1	1.6	-1.0	-1.8	0.0
Medication: Lansoprazole	0.7	0.9	1.8	1.1	1.4	0.2	0.6
Number of full brothers	0.7	0.8	2.2	1.0	1.5	-0.2	0.3
Wheeze or whistling in the chest in last year	0.7	1.3	2.8	1.1	1.1	0.1	1.7
Medication: Blood pressure	0.7	1.3	2.8	1.4	0.2	1.7	-0.4
Overall health rating	0.7	1.5	5.2	-2.3	-0.5	-0.7	-0.4
Medication: Aspirin	0.7	1.0	2.4	1.1	1.6	-0.1	0.6
Smoking status: Current	0.7	1.1	1.8	0.5	1.3	0.9	1.2
Arm fat mass (left)	0.7	2.8	4.8	2.2	1.7	-0.3	1.8
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.7	1.3	0.7	-0.2	-1.0
Supplements: Calcium	0.7	0.8	2.1	-0.8	-1.4	-0.7	0.0
Depressed Affect (Nagel 2018)	0.6	1.3	2.8	-1.7	0.7	0.7	-1.2
LDL Cholesterol	0.6	0.9	1.8	-0.4	1.3	-1.3	0.4
Blood Red Count	0.6	5.7	14.0	-3.7	-0.6	-1.6	-2.5
Smoking Status	0.6	1.4	4.0	2.0	-0.1	0.5	1.2
Tanning	0.6	7.9	22.7	2.1	2.0	0.4	4.8
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.5	0.4	0.9	1.2	-0.1
Medication for hormone replacement therapy	0.6	0.7	1.3	-1.0	1.1	-0.3	-0.4
Hayfever, allergic rhinitis or eczema	0.6	1.4	5.3	-0.1	0.0	-2.3	0.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.9	0.4	-1.4	-0.7	0.4
Number of incorrect matches in round	0.6	0.9	2.3	-0.9	-1.5	0.7	-0.4
Hip circumference	0.6	2.4	4.7	2.2	1.6	0.7	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.5	-1.6	0.7	-0.9	0.2
Pulse rate	0.6	1.0	3.5	0.4	1.9	-0.7	-0.1
Impedance of arm (left)	0.6	2.7	5.2	-2.3	-0.8	1.8	-1.4
Peak expiratory flow (PEF)	0.6	1.3	2.7	0.9	1.0	-1.6	0.8
Age at first live birth	0.6	1.0	2.3	1.5	0.6	0.4	1.0
Angina (self-reported)	0.6	0.8	2.2	1.5	-0.5	0.3	0.6
Medication: Allopurinol	0.6	0.8	2.1	-0.7	-0.7	1.4	-0.1
Heart disease (mother)	0.6	0.7	1.2	-0.7	-1.1	-1.0	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.0	-0.7	-1.4	0.3	0.5
Alcohol intake frequency.	0.6	1.3	4.1	-0.3	0.9	-0.6	2.0
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.9	-1.4	-0.1	0.5	-0.9
Commuting to job workplace: Walk	0.6	0.6	1.8	0.7	0.0	-1.3	0.4
Mineral and other dietary supplements	0.6	0.9	1.3	-1.1	0.7	-0.8	-1.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.9	-1.0	-0.1	1.4	-0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.4	1.2	-0.9	1.0	0.1
Crohns Disease (2017)	0.5	1.1	2.3	-1.2	0.6	1.5	0.5
Irritable Bowel Disease (IBD)	0.5	1.2	4.4	-2.1	-0.2	0.4	-0.6
Reaction Time	0.5	0.9	2.9	0.2	0.5	1.7	0.6
Blood White Count	0.5	3.7	11.8	1.0	1.2	0.9	3.4
Height	0.5	9.6	16.1	-2.1	-2.3	4.0	-3.6
Angina	0.5	0.7	1.8	1.3	-0.6	0.5	0.7
Severe depression (siblings)	0.5	0.5	1.0	-0.7	-1.0	-0.5	-0.6
Current tobacco smoking	0.5	0.8	1.9	0.5	1.4	0.7	0.8
Average weekly fortified wine intake	0.5	0.6	1.6	0.2	-0.4	-1.2	-0.8
Supplements: Glucosamine	0.5	0.6	1.0	-0.6	-1.0	1.0	-0.3
Fluid intelligence score	0.5	1.0	3.2	1.8	0.3	-0.4	0.8
Impedance of arm (right)	0.5	2.3	6.0	-1.6	0.1	2.4	-0.7
Alcohol intake versus 10 years previously	0.5	0.7	2.4	0.7	0.2	-0.2	1.6
Standing height	0.5	4.6	5.4	-2.0	-2.0	2.2	-2.3
Breastfed as a baby	0.5	0.6	1.5	0.0	-1.2	1.0	0.1
Loud music exposure frequency	0.5	0.5	1.5	-0.2	1.2	-0.2	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.0	-0.5	-0.4	-1.4	0.2
Eye problems/disorders: None of the above	0.5	0.6	1.6	-0.2	-1.3	-0.0	-0.9
Medication: Seretide 50 evohaler	0.5	0.6	1.5	0.5	-0.8	0.0	1.2
Pulse rate, automated reading	0.5	1.7	4.1	0.7	1.3	-2.0	0.5
Average weekly red wine intake	0.5	0.7	1.4	1.2	0.4	0.9	0.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	1.1	1.0	0.9	-0.6	1.1
Back pain experienced in last month	0.5	0.7	2.0	-1.4	0.7	0.1	0.7
Breast cancer (self-reported)	0.5	0.6	1.1	0.7	-1.0	-0.9	-0.1
Osteoarthritis (self-reported)	0.5	0.7	1.3	-0.1	1.0	-0.6	1.1
Medication: Aspirin	0.5	0.6	1.7	0.8	1.3	-0.2	0.5
Illnesses of father: None of the above (group 1)	0.5	0.6	0.8	0.5	0.8	-0.8	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.9	-1.7	0.0	-0.8	-0.7
Average weekly champagne plus white wine intake	0.5	0.7	1.5	1.2	-0.5	1.0	0.3
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.5	1.2	-0.8	0.5	0.6
Medication: Paracetamol	0.5	0.8	1.6	-1.3	0.4	0.5	-1.2
Medication: Atorvastatin	0.5	0.6	1.4	0.7	0.3	-1.2	-0.6
Alcohol drinker status: Never	0.5	0.6	1.5	-0.6	0.6	0.6	1.2
Average weekly beer plus cider intake	0.5	0.7	2.3	-1.5	-0.3	0.5	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.1	0.2	1.4	0.1	0.3
Pain experienced in last month	0.5	0.9	3.0	1.7	-0.1	-0.2	0.6
Bipolar Disorder (2018)	0.4	0.7	1.0	-1.0	-1.0	0.2	-0.9
Crohns Disease (2012)	0.4	0.6	2.2	-1.5	0.2	-0.4	-0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.1	-0.4	-1.1	-0.7	-0.2
Systolic Blood Pressure	0.4	2.1	6.6	0.2	-1.2	2.6	-0.5
Allergy or Eczema	0.4	1.0	3.6	-0.4	0.4	-1.9	0.2
Ever had hysterectomy (womb removed)	0.4	0.5	1.6	0.6	0.0	-1.3	0.1
Relative age voice broke	0.4	0.7	1.1	-1.0	-1.1	0.3	-0.7
Sitting height	0.4	2.7	5.1	-1.2	-0.4	2.0	-2.2
Forced vital capacity (FVC)	0.4	1.5	2.8	-1.5	-0.9	0.3	-1.7
Allergy	0.4	0.9	2.6	-0.5	-0.4	1.6	-0.9
Weight	0.4	2.2	3.7	1.9	1.5	0.1	1.6
Hair/balding pattern: Pattern 3	0.4	0.6	1.8	-0.6	-0.4	0.3	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.4	-1.5	-1.1	0.7	-1.2
Blood clot in the leg (DVT)	0.4	0.6	0.9	1.0	0.9	-0.5	0.6
Gout (self-reported)	0.4	0.6	1.7	0.8	0.2	0.1	1.3
Qualifications: College or University degree	0.4	1.2	2.6	1.6	-0.4	-1.4	-0.2
Mean time to correctly identify matches	0.4	0.8	2.6	-0.0	0.5	1.6	0.5
Suffer from ‘nerves’	0.4	0.6	1.9	-1.4	0.1	-0.4	0.5
Chest pain or discomfort	0.4	0.6	1.3	0.6	-0.4	-0.8	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.8	-0.2	0.5	0.9	-0.8
Loneliness, isolation	0.4	0.5	1.9	-1.4	0.2	0.3	0.2
Osteoporosis (self-reported)	0.4	0.6	1.9	-1.4	0.1	-0.3	0.5
Number of self-reported non-cancer illnesses	0.4	0.7	1.4	1.2	0.7	-0.7	0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	1.0	0.7	-0.6	0.3
Average weekly spirits intake	0.3	0.4	1.3	-0.1	-0.6	0.2	-1.1
Diabetes (mother)	0.3	0.4	1.4	-0.1	0.4	-1.2	0.5
Pack years adult smoking proportion	0.3	0.4	0.9	-0.2	0.9	0.7	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.2	1.1	-0.4	-0.9	-0.7
High blood pressure (mother)	0.3	0.4	0.8	0.9	0.2	0.8	0.4
Had menopause	0.3	0.4	0.6	-0.8	0.0	-0.7	0.7
Father’s age at death	0.3	0.4	0.8	-0.7	-0.6	0.1	-0.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.1	-1.5	-0.7	-0.2	-1.3
Medication: Cholesterol lowering	0.3	0.5	0.9	1.0	0.9	0.4	-0.2
Depression (self-reported)	0.3	0.4	0.9	-0.5	1.0	0.3	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	-0.9	0.6	-0.5	0.6
Headache pain in last month	0.3	0.5	0.8	-0.9	0.4	-0.6	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.9	-0.9	0.3	-0.6	-0.0
Shortness of breath walking on level ground	0.3	0.4	1.0	0.2	0.7	1.0	-0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.7	0.1	0.5	0.8	0.6
Illnesses of father: Heart disease	0.3	0.5	1.5	1.2	-0.3	-0.5	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.1	0.7	0.8	0.3
Miserableness	0.3	0.6	1.2	-1.1	0.6	0.6	-0.6
Commuting to job workplace: Public transport	0.3	0.3	0.5	0.7	-0.6	-0.6	0.4
Medication: Lisinopril	0.3	0.4	1.3	1.1	-0.0	0.5	0.0
Ever smoked	0.3	0.6	1.7	1.3	-0.7	-0.1	-0.2
Risk taking	0.3	0.4	1.1	0.3	-0.5	-1.1	0.0
Fractured/broken bones in last 5 years	0.3	0.4	1.0	0.8	-0.1	-1.0	0.1
Cholesterol lowering medication	0.3	0.5	1.2	0.5	-0.5	-1.1	0.5
Heart disease (siblings)	0.3	0.3	0.4	0.6	0.6	-0.7	0.4
Impedance of whole body	0.3	1.5	3.5	-1.9	-0.5	1.4	-0.6
Coronary Artery Disease (CAD)	0.2	0.2	0.9	0.1	-0.1	0.9	0.1
HbA1C	0.2	0.2	0.5	0.4	0.2	0.5	0.7
Heel T-Score	0.2	1.6	2.8	1.1	0.7	1.4	-1.7
Cardiovascular Disease	0.2	0.8	2.6	0.5	-0.1	1.6	-0.7
Lung FEV1/FVC ratio	0.2	1.0	3.8	-0.1	-0.5	-1.9	0.2
Hand grip strength (left)	0.2	0.5	0.9	-0.4	-0.3	0.9	-0.9
Relative age of first facial hair	0.2	0.5	1.2	-0.6	-0.0	-1.1	0.7
Systolic blood pressure, automated reading	0.2	0.7	1.8	-0.2	-0.8	1.4	0.5
Leg fat-free mass (left)	0.2	0.8	2.6	1.6	0.5	0.4	0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.2	0.5	-0.6	-0.2
Qualifications: CSEs or equivalent	0.2	0.3	0.5	0.5	0.7	0.1	-0.5
Multivitamins +/- minerals	0.2	0.3	0.9	0.4	-0.3	-1.0	0.1
Leg predicted mass (left)	0.2	0.8	2.7	1.6	0.5	0.4	0.6
Medication: Simvastatin	0.2	0.3	0.6	0.7	0.5	0.8	0.2
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	0.4	0.7	0.6	0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	-0.4	-1.0	0.2	0.3
Medication: Paracetamol	0.2	0.4	1.3	-0.5	1.2	-0.1	-0.0
Medication: Amlodipine	0.2	0.3	0.6	-0.1	-0.8	0.5	-0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.3	0.2	0.3	0.8
Comparative height size at age 10	0.2	1.4	3.8	0.5	1.1	2.0	0.5
Had major operations	0.2	0.3	0.6	0.3	0.8	0.6	0.4
Illnesses of siblings: Diabetes	0.2	0.3	0.5	-0.3	0.0	-0.7	-0.7
Ever had bowel cancer screening	0.2	0.2	0.7	-0.8	-0.2	-0.3	-0.1
Qualifications: nursing, teaching	0.2	0.3	1.1	1.1	-0.0	0.2	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	-0.5	0.4	0.6	0.2
Medication: Gliclazide	0.2	0.2	0.5	0.7	0.3	0.4	0.3
Age started oral contraceptive pill	0.2	0.3	0.7	-0.6	-0.9	0.3	-0.1
Diastolic blood pressure, automated reading	0.2	0.6	0.9	-0.6	-0.8	0.9	-0.7
Ever depressed for a whole week	0.2	0.3	0.6	-0.8	-0.0	-0.6	0.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.6	0.2	0.6	-0.1
Alcohol drinker status: Previous	0.2	0.2	0.7	-0.8	-0.5	0.2	-0.2
Arm predicted mass (left)	0.2	0.8	2.6	1.6	0.0	-0.1	0.7
Fasting Glucose	0.1	0.1	0.3	0.6	0.3	-0.3	0.3
Blood Eosinophil Count	0.1	0.5	1.7	-0.4	0.6	0.1	1.3
Lung FVC	0.1	0.6	1.9	-1.4	0.7	0.1	-0.3
Number of treatments/medications taken	0.1	0.1	0.2	0.3	0.5	0.5	-0.2
Impedance of leg (right)	0.1	0.4	1.2	-1.1	-0.1	0.6	0.1
Hand grip strength (right)	0.1	0.3	0.7	0.8	-0.2	-0.7	0.2
Maternal smoking around birth	0.1	0.2	0.5	-0.7	0.4	0.2	-0.0
Stomach or abdominal pain in last month	0.1	0.1	0.4	-0.3	-0.0	-0.2	0.6
Impedance of leg (left)	0.1	0.6	1.4	-1.2	-0.3	0.9	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	0.2	-0.5	-0.3	-0.7
Trunk fat-free mass	0.1	0.5	1.0	1.0	-0.7	0.7	-0.4
Trunk predicted mass	0.1	0.6	0.9	1.0	-0.8	0.8	-0.5
Glaucoma (self-reported)	0.1	0.2	0.6	-0.3	0.1	0.7	0.1
Arm fat-free mass (right)	0.1	0.5	1.5	1.2	-0.5	-0.5	0.3
Exposure to tobacco smoke outside home	0.1	0.2	0.3	-0.6	0.2	-0.4	0.4
Emphysema/chronic bronchitis	0.1	0.2	0.3	-0.4	0.4	-0.6	-0.0
Arm predicted mass (right)	0.1	0.4	1.1	1.1	-0.4	-0.4	0.3
Knee pain experienced in last month	0.1	0.1	0.2	-0.2	0.4	-0.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	0.7	0.0	0.3	0.5
Whole body fat-free mass	0.1	0.5	1.7	1.3	-0.3	0.5	0.0
Leg fat-free mass (right)	0.1	0.6	2.0	1.4	0.3	0.5	0.3
Whole body water mass	0.1	0.5	1.6	1.3	-0.3	0.5	0.0
Leg predicted mass (right)	0.1	0.7	2.2	1.5	0.3	0.4	0.4
Basal metabolic rate	0.1	0.7	2.4	1.6	0.2	0.4	0.5
Arm fat-free mass (left)	0.1	0.6	2.1	1.4	-0.3	-0.1	0.5
Pack years of smoking	0.1	0.2	0.4	-0.3	0.6	0.5	0.3
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	-0.0	-0.3	-0.2	-0.1
Sensitivity / hurt feelings	0.0	0.1	0.1	-0.4	-0.1	0.1	-0.2

Hub : Genes

GPR98

Models

Trait associations