TWAS hub - GRAMD1A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2760	0.0730	3.4e-04	-0.005	NA	0.014	NA	0.001	7.5e-01	NA	5.3e-02	NA	2.9e-01
2	GTEx	Breast Mammary Tissue	0.1830	0.0730	5.2e-03	-0.003	NA	0.055	NA	0.017	4.8e-01	NA	8.0e-04	NA	4.5e-02
3	GTEx	Breast Mammary Tissue (Male)	0.1001	0.1174	2.5e-01	-0.008	NA	-0.004	NA	-0.013	5.4e-01	NA	4.0e-01	NA	8.6e-01
4	GTEx	Breast Mammary Tissue (Female)	0.0820	0.0875	2.1e-01	-0.005	NA	-0.006	NA	0.002	4.7e-01	NA	5.5e-01	NA	2.7e-01
5	GTEx	Cells Transformed fibroblasts	0.2460	0.0640	1.4e-05	-0.001	NA	0.063	NA	0.037	3.8e-01	NA	1.8e-05	NA	9.0e-04
6	GTEx	Muscle Skeletal	0.0996	0.0356	2.1e-03	0.010	NA	0.014	NA	0.006	3.3e-02	NA	1.3e-02	NA	8.1e-02
7	GTEx	Thyroid	0.1390	0.0510	4.7e-03	0.018	NA	0.012	NA	0.022	1.5e-02	NA	3.6e-02	NA	8.1e-03
8	GTEx	Whole Blood	0.1960	0.0500	4.0e-05	0.131	NA	0.115	NA	0.121	4.7e-12	NA	9.7e-11	NA	3.1e-11
9	METSIM	Adipose	0.1105	0.0378	1.2e-03	0.057	0.029	0.042	0.058	0.048	6.1e-09	2.7e-05	5.3e-07	4.5e-09	8.6e-08
10	YFS	Blood	0.0859	0.0183	8.2e-10	0.048	0.043	0.061	0.054	0.051	1.8e-15	6.9e-14	3.5e-19	4.3e-17	3.2e-16
11	TCGA	Breast Invasive Carcinoma	0.0599	0.0208	3.3e-06	0.036	0.032	0.033	NA	0.040	5.7e-08	3.1e-07	2.3e-07	NA	9.5e-09
12	TCGA	Head and Neck Squamous Cell Carcinoma	0.0589	0.0289	6.5e-03	0.050	0.012	0.031	NA	0.044	2.8e-06	1.5e-02	1.7e-04	NA	9.1e-06
13	TCGA	Kidney Renal Clear Cell Carcinoma	0.0700	0.0322	1.6e-03	0.013	0.033	0.025	NA	0.026	1.1e-02	1.2e-04	6.4e-04	NA	5.2e-04
14	TCGA	Brain Lower Grade Glioma	0.0907	0.0343	2.3e-04	0.067	0.030	0.040	NA	0.051	4.3e-08	2.2e-04	2.1e-05	NA	1.8e-06
15	TCGA	Lung Adenocarcinoma	0.0475	0.0232	8.2e-03	0.000	0.008	0.009	NA	0.002	3.2e-01	3.1e-02	3.0e-02	NA	1.7e-01
16	TCGA	Lung Squamous Cell Carcinoma	0.0741	0.0289	2.8e-04	0.026	0.021	0.027	NA	0.025	5.9e-04	1.5e-03	4.3e-04	NA	7.1e-04
17	TCGA	Ovarian Serous Cystadenocarcinoma	0.1390	0.0450	1.7e-05	0.080	0.061	0.041	NA	0.064	4.4e-06	6.2e-05	8.3e-04	NA	3.8e-05
18	TCGA	Prostate Adenocarcinoma	0.0556	0.0259	3.8e-03	0.030	0.035	0.039	NA	0.033	3.6e-04	1.2e-04	6.1e-05	NA	2.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Ever had hysterectomy (womb removed)	4.8	5.4	12.1	-0.9	-1.8	0.2	-1.3	-0.5	-3.0	-3.1	-2.1	-2.2	-2.7	-2.9	-1.7	-2.9	-3.5	-2.6	-2.9	-2.8
Exposure to tobacco smoke at home	4.7	5.3	9.9	1.8	1.0	0.5	0.9	-0.1	2.9	2.8	3.1	2.9	2.5	2.7	2.8	2.7	3.1	2.1	2.8	2.1
Major Depression (MDD)	4.6	5.6	9.9	-1.8	-0.9	-1.5	-1.2	-1.4	-3.0	-3.0	-2.8	-2.4	-3.1	-3.0	-2.4	-3.0	-2.5	-1.9	-3.0	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	4.3	5.7	11.2	-2.4	-0.2	0.6	-2.3	-1.6	-3.4	-3.0	-3.1	-2.6	-2.6	-2.6	-2.2	-2.6	-3.3	-1.4	-2.7	-2.5
Length of working week for main job	4.0	4.4	8.6	1.7	1.7	0.2	0.1	1.1	2.6	2.5	2.9	2.3	2.4	2.7	2.0	2.7	2.4	1.6	2.6	2.3
Mineral and other dietary supplements	3.2	4.3	9.5	-0.1	0.9	1.6	-0.4	1.6	2.5	2.4	1.9	3.1	2.3	2.5	2.5	2.5	1.8	2.7	2.5	2.1
Depression (Nagel 2018)	2.9	4.4	8.0	-1.4	0.9	-0.0	-1.0	-2.0	-2.8	-2.5	-2.4	-2.8	-2.5	-2.3	-2.3	-2.3	-2.3	-1.8	-2.4	-2.7
Frequency of depressed mood in last 2 weeks	2.9	4.1	8.5	-0.9	-0.8	-0.3	-1.4	-0.9	-2.8	-2.6	-2.5	-2.1	-2.3	-2.3	-1.5	-2.3	-2.9	-2.4	-2.4	-2.3
Unable to work because of sickness or disability	2.9	3.8	9.0	-2.0	-0.3	0.6	-1.9	-0.8	-2.4	-2.4	-1.9	-2.1	-2.5	-2.3	-0.8	-2.3	-2.1	-2.0	-2.3	-3.0
Guilty feelings	2.8	4.3	8.2	-1.4	-2.4	-0.3	-2.9	0.1	-2.4	-2.3	-2.2	-1.6	-2.1	-2.2	-2.6	-2.2	-2.9	-2.1	-2.3	-1.9
Supplements: Fish oil (including cod liver oil)	2.8	3.6	9.4	0.7	-1.6	-1.4	-1.0	-0.4	-2.3	-2.4	-1.5	-2.7	-1.8	-2.3	-1.4	-2.2	-1.6	-3.1	-2.3	-2.4
Vitamin and mineral supplements	2.5	3.4	8.4	-0.2	1.1	0.3	0.4	0.6	2.2	2.3	1.5	2.9	1.9	2.4	0.9	2.4	2.4	2.4	2.4	2.3
Supplements: Calcium	2.5	2.7	5.3	-1.8	0.4	0.9	0.4	0.1	-2.0	-2.0	-1.9	-2.3	-1.5	-2.3	-2.0	-2.2	-2.1	-1.1	-2.2	-1.1
Serious illness, injury or assault to yourself	2.4	3.0	6.0	-2.4	-1.3	-0.3	-0.1	-0.5	-2.0	-2.1	-1.4	-1.9	-1.8	-2.2	-1.4	-2.1	-1.8	-2.2	-2.1	-2.1
Ever highly irritable/argumentative for 2 days	2.4	2.9	7.2	-1.4	-1.7	1.2	-2.4	-0.5	-2.0	-2.0	-1.8	-1.5	-1.4	-1.8	-0.1	-1.8	-2.7	-1.7	-1.8	-1.9
Happiness	2.3	2.7	6.4	0.8	-0.3	-0.4	-2.1	-0.5	-1.9	-2.2	-1.2	-1.5	-1.8	-2.2	-0.1	-2.2	-2.5	-1.7	-2.1	-2.2
Eye problems/disorders: Cataract	2.3	2.7	4.8	-0.2	-0.3	-0.6	1.0	0.2	-2.1	-2.0	-2.2	-1.7	-1.7	-2.2	-1.8	-2.2	-2.2	-1.7	-2.2	-1.6
Medication: Ramipril	2.2	2.8	11.0	1.3	-1.9	-3.3	-1.1	-0.3	-1.9	-1.9	-1.0	-1.1	-1.9	-2.1	-0.2	-2.1	-1.3	-1.2	-2.0	-1.9
Neuroticism score	2.2	4.6	9.6	-0.9	-2.3	-0.2	-2.6	-0.8	-2.5	-2.6	-2.6	-2.4	-2.3	-2.3	-2.4	-2.3	-3.1	-1.5	-2.4	-2.1
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	6.5	-2.5	-0.7	0.3	-0.9	-0.7	-1.8	-1.6	-1.2	-1.7	-1.9	-1.8	-1.2	-1.8	-1.9	-0.9	-1.7	-1.7
Fed-up feelings	2.1	3.8	7.2	-1.0	-2.4	-0.8	-2.3	-0.0	-2.2	-2.4	-2.2	-2.0	-2.1	-2.3	-1.8	-2.3	-2.7	-1.2	-2.3	-2.0
Number of children fathered	2.1	2.4	6.5	-0.3	1.7	2.1	1.1	0.7	1.5	1.4	1.6	2.5	1.7	1.7	1.8	1.7	1.0	1.8	1.7	1.2
Mouth/teeth dental problems: Loose teeth	2.1	2.5	4.7	0.2	0.4	-0.4	-0.1	0.2	1.9	2.0	2.2	2.0	2.0	2.1	1.5	2.1	1.9	1.1	2.1	1.9
Overall health rating	2.1	4.4	7.4	-0.9	-2.6	-0.9	-2.2	-1.1	-2.6	-2.6	-1.7	-2.1	-2.4	-2.5	-1.1	-2.5	-2.4	-2.4	-2.5	-2.7
Long-standing illness, disability or infirmity	2.1	3.3	6.6	-0.7	-1.4	0.8	-2.6	-0.3	-2.2	-2.2	-1.3	-2.1	-2.1	-2.4	-0.9	-2.3	-2.3	-1.6	-2.2	-2.2
Depressed Affect (Nagel 2018)	2.0	4.2	7.6	-1.0	-2.1	-1.6	-2.0	-1.6	-2.4	-2.3	-2.5	-2.3	-2.4	-2.1	-2.8	-2.2	-2.6	-1.0	-2.2	-2.0
Alzheimer’s Disease (in mother)	2.0	2.3	4.3	0.3	-1.4	0.9	-1.9	2.0	-1.7	-1.5	-1.9	-2.1	-0.6	-1.6	-1.2	-1.6	-2.0	-2.0	-1.6	-0.2
Neuroticism	2.0	4.8	8.8	-1.1	-2.2	-0.7	-2.3	-1.3	-2.6	-2.6	-2.4	-2.6	-2.4	-2.5	-2.1	-2.5	-3.0	-1.9	-2.5	-2.5
Multivitamins +/- minerals	2.0	2.6	9.3	0.7	-0.4	-0.1	0.6	-1.3	-1.8	-1.9	-1.8	-3.0	-1.8	-1.8	-1.6	-1.9	-1.8	-1.6	-2.0	-1.5
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	6.9	-0.8	-1.5	0.0	-1.6	0.2	-2.4	-2.2	-2.6	-2.3	-1.6	-1.9	-2.3	-1.9	-2.5	-1.2	-2.1	-1.1
Stomach or abdominal pain in last month	1.9	2.3	6.9	-0.6	-2.6	-1.2	-2.0	-0.2	-1.7	-1.7	-1.6	-0.7	-1.3	-1.4	-1.2	-1.4	-2.1	-2.2	-1.6	-1.4
Medication: Ventolin 100micrograms inhaler	1.9	2.5	6.6	-1.7	-1.1	0.4	-2.6	-0.4	-1.8	-1.7	-1.8	-1.4	-1.5	-1.8	-2.2	-1.8	-1.4	-1.5	-1.9	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.3	6.9	0.8	2.6	-0.6	1.2	0.7	2.1	1.8	1.6	1.9	1.6	1.6	0.3	1.6	1.6	0.7	1.6	1.8
Knee pain experienced in last month	1.9	2.9	5.6	-0.1	-2.4	-0.8	-0.7	-0.3	-2.1	-2.0	-1.9	-1.7	-2.2	-2.2	-1.6	-2.2	-1.8	-1.1	-2.2	-1.7
Miserableness	1.9	3.2	6.0	-0.6	-2.0	-0.5	-0.6	-1.7	-2.2	-2.1	-1.9	-2.0	-2.4	-2.0	-2.1	-2.0	-2.0	-1.2	-2.0	-2.2
Depression (self-reported)	1.8	2.1	7.7	-1.1	-0.1	-0.7	-2.8	-0.8	-1.8	-1.6	-1.7	-1.2	-1.6	-1.5	-0.8	-1.5	-2.2	-1.2	-1.5	-1.2
Fasting Glucose	1.7	2.0	4.3	-1.5	-0.5	-2.1	-1.4	-1.7	-1.6	-1.4	-1.2	-1.3	-1.3	-1.5	-2.1	-1.5	0.0	-1.2	-1.5	-1.2
Leg fat percentage (left)	1.7	6.1	11.7	0.6	-0.7	-1.2	-0.6	1.6	2.8	3.2	3.1	3.4	3.1	3.1	2.0	3.2	3.1	2.0	3.2	3.0
Blood White Count	1.6	12.1	32.9	-3.4	-2.4	-0.4	-5.0	-0.3	-3.6	-3.9	-3.3	-2.5	-3.1	-4.1	-3.5	-4.0	-3.9	-5.7	-4.2	-3.0
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	5.2	0.4	-0.3	-0.6	-0.9	0.8	-1.9	-2.0	-1.1	-0.5	-1.6	-1.8	0.2	-1.8	-2.3	-1.3	-1.7	-2.1
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	5.3	-0.4	-1.4	-1.4	-1.0	-0.6	-2.3	-2.1	-1.8	-1.8	-2.0	-1.6	-1.4	-1.6	-2.2	-0.9	-1.7	-2.2
Emphysema/chronic bronchitis	1.6	1.8	4.7	-2.2	0.2	0.6	-0.8	0.0	-1.6	-1.7	-1.5	-1.3	-1.3	-1.6	0.1	-1.5	-1.8	-1.3	-1.6	-1.8
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	4.2	-1.7	-0.2	-0.2	-1.6	1.6	-1.7	-1.5	-1.0	-1.3	-1.4	-1.7	-1.2	-1.7	-1.6	-2.1	-1.6	-1.5
Verbal and Numeric Reasoning (VNR)	1.5	3.7	8.1	-2.0	-2.0	-0.6	0.1	-2.2	-1.9	-2.0	-2.3	-2.5	-2.1	-2.0	-2.8	-2.0	-1.2	-2.1	-2.1	-1.7
Coronary Artery Disease (CAD)	1.5	1.8	4.8	1.0	0.5	0.0	-0.7	0.1	1.4	1.5	2.1	2.1	1.6	1.6	1.1	1.6	0.0	0.9	1.6	2.2
HDL Cholesterol	1.5	2.5	8.1	-0.7	0.1	1.4	-2.9	0.1	-1.9	-1.8	-1.6	-1.6	-1.7	-2.0	0.1	-1.9	0.0	-1.6	-1.9	-2.5
Supplements: Zinc	1.5	1.6	2.9	-0.5	-0.2	-1.5	0.3	-0.6	-1.3	-1.3	-1.5	-1.6	-1.7	-1.6	-1.4	-1.6	-0.8	-1.6	-1.6	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	4.4	1.8	-2.1	-0.3	0.1	0.4	1.8	1.4	1.8	0.6	1.9	1.5	1.5	1.5	0.8	0.4	1.5	1.3
Leg fat percentage (right)	1.5	5.4	9.8	0.4	-0.7	-1.5	-1.0	1.6	2.5	2.9	2.9	3.1	2.9	2.9	1.8	3.0	2.9	2.0	3.0	2.8
Neuroticism (Nagel 2018)	1.4	3.3	7.8	-0.7	-2.0	-0.7	-1.9	-1.2	-2.1	-2.1	-2.3	-2.1	-1.8	-1.8	-2.1	-1.8	-2.8	-1.0	-1.9	-1.9
Reaction Time	1.4	2.7	6.1	0.6	-2.1	-1.0	-2.5	-0.4	-1.8	-1.8	-1.6	-1.9	-2.0	-1.9	-0.8	-1.9	-1.4	-1.4	-1.9	-1.9
Illnesses of mother	1.4	1.7	4.4	0.0	1.2	-0.5	2.1	-1.7	1.6	1.3	0.8	1.5	0.8	1.6	-0.0	1.6	2.0	1.1	1.5	0.8
Number of self-reported non-cancer illnesses	1.4	2.4	5.9	-0.6	-1.3	-1.7	-2.2	-0.8	-2.0	-1.8	-0.7	-1.5	-1.7	-1.9	-0.3	-1.9	-2.4	-1.0	-1.8	-1.7
Blood clot in the leg (DVT)	1.3	1.7	4.2	-1.8	-0.2	-0.1	-1.4	1.7	-1.4	-1.3	-0.8	-1.2	-1.1	-1.4	-1.0	-1.4	-1.3	-2.0	-1.4	-1.4
Medication: Omeprazole	1.3	1.6	5.2	-2.3	-1.0	1.3	-2.0	-2.1	-1.0	-1.0	-1.4	-0.4	-1.2	-0.8	-1.3	-0.8	-1.4	-0.7	-1.0	-0.8
Mood swings	1.3	2.4	8.6	-0.5	-2.9	-1.0	-2.9	-0.3	-1.3	-1.5	-1.8	-0.9	-1.4	-1.5	-1.2	-1.5	-2.0	-1.0	-1.5	-1.2
Mean time to correctly identify matches	1.2	2.3	4.4	1.0	-1.4	-0.8	-1.1	-0.7	-1.8	-1.9	-1.7	-1.7	-2.0	-1.8	-0.6	-1.8	-1.5	-1.3	-1.8	-2.1
Alcohol drinker status: Never	1.2	1.4	6.2	-2.2	0.7	2.5	0.8	-1.3	-1.1	-0.9	-1.0	-1.7	-0.8	-0.8	-1.1	-0.8	-0.6	0.1	-0.8	-1.0
Heart disease (siblings)	1.2	1.4	4.4	-2.1	0.8	-0.0	-1.3	-0.1	-1.6	-1.4	-0.9	-0.8	-1.1	-1.3	0.3	-1.3	-2.1	0.5	-1.2	-1.5
Leg fat mass (left)	1.2	4.9	9.0	1.2	-0.3	-1.9	-0.6	1.5	2.2	2.6	3.0	3.0	2.6	2.7	2.3	2.7	2.6	1.8	2.7	2.3
Supplements: Glucosamine	1.1	1.5	4.1	0.6	-0.4	0.1	-0.7	-1.2	-1.5	-1.6	-0.7	-0.8	-1.4	-1.7	-0.6	-1.7	-2.0	-1.4	-1.6	-1.3
Fluid intelligence score	1.1	2.3	8.0	-0.6	-2.8	-0.8	-0.6	-1.6	-1.2	-1.3	-1.4	-1.9	-1.6	-1.5	-2.5	-1.5	-0.3	-2.2	-1.6	-1.0
Falls in the last year	1.1	1.4	5.1	-0.6	-2.3	0.8	-0.8	1.6	-1.4	-1.5	-0.9	-0.8	-0.5	-0.9	0.3	-0.9	-2.2	-1.3	-1.0	-1.3
Tense / ‘highly strung’	1.1	1.8	4.3	-0.6	-1.7	0.1	-1.7	-1.2	-1.4	-1.4	-2.0	-1.8	-1.1	-1.1	-2.1	-1.1	-1.8	-0.9	-1.3	-0.4
Body fat percentage	1.1	4.4	9.9	1.3	-1.1	-1.3	-1.3	1.3	2.2	2.6	2.6	3.1	2.5	2.5	1.8	2.6	2.5	1.5	2.6	2.4
Smoking status: Current	1.1	1.7	8.6	-2.9	-0.7	-1.3	-0.5	-1.2	-1.3	-1.0	-1.4	-1.1	-1.5	-1.2	-2.0	-1.2	-0.6	-1.1	-1.3	-0.7
Ever taken oral contraceptive pill	1.1	1.2	3.8	-1.5	0.7	0.6	0.9	0.5	1.0	1.2	0.9	1.9	1.3	1.4	0.2	1.4	0.9	0.6	1.3	1.7
Medication: Blood pressure	1.1	2.1	6.5	1.5	-1.0	-2.6	-0.9	1.0	1.6	1.4	1.9	1.6	1.4	1.4	1.6	1.4	1.5	0.9	1.4	1.2
Alzheimer’s Disease (in father)	1.0	1.1	5.3	2.3	-2.3	-1.2	1.3	0.8	1.0	0.9	0.8	0.5	0.5	0.6	0.2	0.6	1.3	-0.1	0.7	0.5
Ovarian Cancer	1.0	1.3	2.7	1.6	0.6	-1.0	1.4	-1.5	-1.2	-1.3	-0.7	-1.2	-1.1	-1.2	-1.7	-1.2	-0.7	-0.9	-1.3	-0.8
Age at First Birth	1.0	1.5	6.8	-0.9	1.8	0.8	2.6	-0.4	1.2	1.1	0.2	1.1	1.0	1.1	0.3	1.1	0.0	2.1	1.2	1.1
Body Mass Index (BMI) (2010)	1.0	1.4	2.9	0.2	1.0	-0.4	0.1	1.1	1.2	1.4	1.6	0.9	1.7	1.5	1.6	1.5	0.0	1.3	1.6	1.3
BMI	1.0	6.0	10.2	2.0	-0.5	-2.6	0.2	0.9	2.7	3.0	3.2	2.9	2.8	3.1	2.2	3.1	2.9	2.3	3.1	2.6
Current tobacco smoking	1.0	1.6	7.7	-2.8	-0.4	-1.3	0.2	-1.7	-1.2	-0.9	-1.3	-1.1	-1.4	-0.9	-2.1	-1.0	-0.5	-0.8	-1.1	-0.8
Arm fat percentage (right)	1.0	3.9	8.0	1.4	-0.5	-1.2	-1.3	1.0	2.1	2.4	2.4	2.8	2.4	2.5	1.8	2.5	2.2	1.7	2.5	2.2
Lung cancer (father)	1.0	1.2	2.9	-0.9	0.8	-0.5	-0.1	0.9	1.4	1.3	1.1	0.9	1.0	1.2	0.5	1.3	1.7	1.7	1.3	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	4.4	1.1	-0.7	-1.4	-2.1	-1.0	-1.3	-1.1	-0.8	-1.4	-1.0	-1.0	-1.2	-1.0	-0.7	-1.4	-1.1	-1.1
Neck or shoulder pain in last month	1.0	1.4	3.7	1.1	-0.5	-0.8	0.2	0.5	1.4	1.4	1.9	0.9	1.3	1.5	1.3	1.5	1.6	0.9	1.4	0.8
Whole body fat mass	1.0	4.2	8.7	1.6	-0.6	-1.7	-1.0	1.3	2.1	2.4	2.8	3.0	2.3	2.4	2.4	2.5	2.4	1.6	2.5	2.0
Leg fat mass (right)	1.0	4.0	7.4	1.0	-0.4	-2.2	-0.7	1.4	1.9	2.3	2.7	2.7	2.3	2.4	2.1	2.4	2.3	1.7	2.4	2.1
Arm fat percentage (left)	1.0	3.9	7.7	1.5	-0.4	-1.2	-0.9	0.9	2.2	2.4	2.5	2.8	2.4	2.5	1.9	2.5	2.3	1.6	2.5	2.1
Eye problems/disorders: Glaucoma	1.0	1.1	7.1	1.3	-0.3	-2.7	-0.1	0.6	1.1	0.9	1.5	1.2	0.6	0.8	0.8	0.8	0.8	1.1	0.9	0.8
Relative age of first facial hair	0.9	1.9	4.5	0.8	1.1	1.1	-0.2	-1.9	-1.5	-1.6	-2.1	-1.9	-1.6	-1.2	-1.8	-1.2	-1.6	-0.4	-1.3	-1.2
Average weekly fortified wine intake	0.9	1.0	4.2	0.2	0.5	0.5	0.2	-0.4	-0.9	-1.1	-2.0	-2.0	-0.5	-1.0	-1.2	-1.0	-1.2	-1.1	-1.1	-0.4
Qualifications: CSEs or equivalent	0.9	1.1	3.9	-0.7	0.8	0.7	-0.3	1.3	1.0	0.9	1.4	1.2	1.1	1.1	2.0	1.1	0.4	1.4	1.2	0.8
Body mass index (BMI)	0.9	3.8	7.4	0.9	-0.2	-1.7	-0.8	0.8	2.1	2.4	2.7	2.6	2.2	2.5	1.8	2.5	2.5	1.8	2.5	2.0
Hip circumference	0.9	3.8	6.6	2.2	-0.6	-1.9	-0.4	1.6	1.9	2.2	2.5	2.3	2.1	2.3	2.6	2.3	2.2	1.8	2.3	1.5
Arm fat mass (right)	0.9	3.9	7.7	1.7	-0.4	-1.9	-1.2	1.0	2.0	2.3	2.5	2.8	2.2	2.4	2.1	2.4	2.2	1.5	2.4	1.9
Suffer from ‘nerves’	0.9	1.4	3.4	-0.6	-1.1	1.0	-1.5	0.1	-1.4	-1.3	-1.8	-1.2	-0.6	-0.9	-1.6	-0.9	-1.7	-1.1	-1.1	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	5.1	0.6	-0.0	0.3	-2.3	0.3	-0.8	-1.0	-0.7	-0.1	-0.7	-1.1	-0.3	-1.1	-1.5	-2.2	-1.1	-0.6
Ever had bowel cancer screening	0.9	1.1	3.4	-0.7	-0.4	-1.4	-0.3	-1.4	0.7	1.0	1.6	0.7	0.8	1.1	0.9	1.1	1.2	1.9	1.1	0.5
Mother’s age at death	0.9	1.1	4.1	-0.7	-1.1	0.3	-1.0	1.9	-0.8	-0.8	-0.7	-0.8	-0.6	-1.1	-1.3	-1.0	-1.1	-2.0	-1.1	-0.1
Irritability	0.9	1.5	4.8	0.3	-0.8	-0.4	-1.5	-0.2	-1.2	-1.5	-1.0	-1.9	-1.3	-1.4	-0.4	-1.4	-2.2	-0.8	-1.4	-1.5
Pain experienced in last month	0.9	1.5	3.4	-0.7	1.8	0.7	1.8	1.6	1.1	1.3	1.6	0.9	1.4	0.9	1.4	1.0	1.8	0.2	1.1	1.0
Intelligence (Savage-Jansen 2018)	0.8	2.6	5.5	-1.4	-1.5	-0.2	-0.2	-2.0	-1.7	-1.7	-1.9	-2.2	-1.7	-1.6	-2.0	-1.6	-1.0	-2.3	-1.7	-1.7
Alzheimer’s Disease (including proxy)	0.8	1.1	7.2	1.9	-2.3	-0.5	-0.4	2.7	-0.2	-0.2	-0.4	-0.9	0.1	-0.6	-0.1	-0.6	-0.5	-1.1	-0.5	0.6
Lung FVC	0.8	4.3	11.7	-0.7	0.7	0.7	1.2	-2.5	-2.3	-2.6	-2.3	-2.7	-2.5	-2.3	-1.3	-2.4	-2.1	-1.6	-2.4	-3.4
Trunk fat percentage	0.8	3.2	8.1	1.3	-1.3	-1.0	-1.6	0.9	1.8	2.1	2.2	2.8	2.1	2.1	1.7	2.1	2.0	1.1	2.1	2.0
Nervous feelings	0.8	1.5	5.0	-0.1	-0.6	0.8	-1.8	0.1	-1.6	-1.5	-1.9	-1.4	-0.5	-1.0	-1.2	-1.0	-2.2	-1.5	-1.2	-0.7
Father’s age at death	0.8	1.1	2.7	-1.0	0.4	1.6	-0.7	-0.5	-0.5	-0.8	-1.3	-1.6	-0.8	-1.0	-1.6	-1.0	-0.9	-1.4	-1.0	-0.6
Health satisfaction	0.8	1.1	3.8	-0.2	-1.1	0.0	-2.0	-1.2	-0.7	-1.1	-0.3	-1.0	-1.1	-1.2	0.7	-1.2	-1.1	-0.6	-1.1	-1.7
Medication for pain relief, constipation, heartburn	0.8	1.4	4.1	1.0	0.7	1.2	1.5	1.1	1.3	1.2	1.1	0.7	1.4	1.1	2.0	1.2	1.0	1.3	1.3	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	3.3	1.0	-1.2	-1.5	0.6	-1.8	-0.6	-0.9	-0.0	-0.8	-1.2	-0.8	-0.0	-0.8	-0.7	-0.6	-0.8	-1.4
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.7	1.1	-0.0	1.7	-1.5	1.0	-1.0	-1.0	-0.8	-1.0	-0.2	-0.8	-0.1	-0.8	-1.4	-1.2	-0.8	-0.7
Medication for cholesterol	0.8	1.2	2.8	-0.7	0.5	0.7	0.1	-0.2	-1.4	-1.2	-1.7	-1.3	-0.8	-1.3	-1.4	-1.2	-1.5	-1.7	-1.3	-0.7
Illnesses of father: None of the above (group 1)	0.8	1.0	2.2	-1.1	0.9	0.5	0.7	-0.8	-1.1	-1.2	-1.0	-0.9	-1.5	-1.4	-0.7	-1.4	-0.8	-0.1	-1.3	-1.3
Arm fat mass (left)	0.8	3.1	6.6	1.4	-0.5	-1.9	-1.2	1.1	1.8	2.0	2.3	2.6	2.0	2.1	1.8	2.1	2.0	1.2	2.1	1.7
Fractured/broken bones in last 5 years	0.8	1.1	5.0	-0.3	0.7	-0.8	-2.2	0.4	-1.1	-1.2	-0.8	-0.6	-0.9	-1.1	-0.1	-1.1	-1.9	-0.8	-1.0	-1.1
Myopia	0.8	1.1	7.5	-0.4	1.1	0.7	2.7	0.3	1.0	1.0	0.9	0.7	0.9	1.0	-0.0	1.0	0.9	1.3	1.0	0.9
Alcohol drinker status: Previous	0.8	0.9	2.7	0.9	-0.1	-0.3	-1.6	1.6	0.6	0.6	1.5	1.1	1.0	0.8	1.6	0.8	-0.1	0.0	0.8	0.7
HbA1C	0.7	0.8	2.0	-1.4	-1.0	-0.3	-0.7	-0.9	-1.1	-1.2	-1.2	-1.1	-0.5	-0.9	-1.0	-0.9	0.0	0.9	-0.9	-0.7
Number of treatments/medications taken	0.7	1.2	6.2	-0.8	-1.1	-1.5	-2.5	0.2	-1.1	-1.1	-0.4	-0.6	-1.0	-1.3	-0.3	-1.3	-1.6	-0.3	-1.1	-0.8
Hearing difficulty/problems: Yes	0.7	1.0	3.3	0.9	0.2	-1.2	1.4	-1.3	0.9	0.8	1.2	1.0	0.3	0.7	0.8	0.7	1.4	1.8	0.8	0.8
Systolic blood pressure, automated reading	0.7	1.9	3.5	0.5	0.5	-0.1	-0.6	1.6	1.7	1.7	1.0	1.3	1.8	1.8	1.3	1.8	1.9	1.2	1.8	1.8
Medication: Co-codamol	0.7	0.9	4.6	-2.1	-0.5	1.1	-2.0	1.6	-0.6	-0.4	-0.3	-0.4	-0.4	-0.7	0.6	-0.6	-0.5	0.1	-0.5	-0.5
Taking other prescription medications	0.7	1.1	3.1	-1.7	-0.4	-0.3	-1.8	0.2	-1.4	-1.1	-0.4	-0.7	-1.2	-1.4	-0.7	-1.4	-1.3	-0.6	-1.3	-0.6
High blood pressure (mother)	0.7	1.0	3.2	0.4	0.0	-0.1	-1.2	1.2	1.0	1.1	0.8	1.4	0.9	0.9	1.1	0.9	0.6	1.8	1.0	1.3
Trunk fat mass	0.7	3.2	6.9	1.4	-0.8	-1.5	-1.2	1.2	1.7	2.1	2.4	2.6	2.0	2.0	2.1	2.0	2.0	1.3	2.1	1.7
Had other major operations	0.7	0.9	4.0	-2.0	-0.0	-0.2	-1.5	-0.0	-1.2	-1.1	-1.2	-0.9	-0.8	-0.8	-0.2	-0.8	-1.6	-0.0	-0.8	-0.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.8	-1.2	0.7	1.1	-0.7	-0.5	-1.0	-1.1	-1.2	-0.9	-0.9	-1.0	-0.9	-1.1	-1.4	-0.7	-1.1	-0.3
Hair/balding pattern: Pattern 3	0.7	1.1	3.9	2.0	0.6	-0.1	-1.0	0.5	1.2	1.2	1.4	0.7	1.1	1.0	0.5	1.1	1.7	0.1	1.1	0.7
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.9	-1.0	-0.7	1.3	-1.1	1.6	-0.6	-0.6	-1.1	-0.7	0.5	-0.0	0.3	-0.0	-1.7	-0.9	-0.2	-0.6
Comparative body size at age 10	0.7	2.0	4.7	1.4	1.9	-2.1	1.4	0.3	1.1	1.4	2.2	0.3	1.8	1.4	1.3	1.5	1.1	1.6	1.5	1.3
Worry too long after embarrassment	0.7	1.2	3.6	-0.6	-1.6	-0.2	-0.4	0.0	-1.4	-1.4	-1.4	-1.1	-1.0	-1.2	-0.9	-1.2	-1.9	-0.3	-1.2	-1.0
Heart disease (mother)	0.7	0.9	4.6	1.6	-1.1	-2.1	-1.2	-0.1	-0.7	-0.7	0.2	-0.4	-0.7	-0.8	0.7	-0.8	-0.8	-0.3	-0.7	-1.0
Commuting to job workplace: Cycle	0.7	0.8	3.8	0.4	-1.5	-0.9	0.4	-1.9	0.4	0.6	0.3	-0.7	-0.4	0.7	-1.9	0.6	1.3	0.5	0.5	0.2
Cholesterol lowering medication	0.7	1.0	2.1	1.0	1.0	0.7	-0.1	0.4	1.2	1.3	1.4	0.7	1.1	1.3	0.3	1.3	1.5	0.8	1.3	1.0
Bipolar Disorder (2018)	0.6	0.9	4.4	-0.1	0.3	1.8	0.1	-0.3	-1.3	-1.1	-0.6	-0.5	-1.2	-1.0	1.0	-1.0	0.0	-0.1	-0.9	-2.1
Bipolar Disorder or Schizophrenia	0.6	1.6	6.2	0.3	-1.6	1.8	-0.3	-0.3	-1.8	-1.5	-1.1	-0.7	-1.6	-1.3	0.7	-1.4	0.0	-0.3	-1.3	-2.5
Triglycerides	0.6	0.9	1.6	0.5	0.7	1.1	1.2	-0.2	1.3	1.1	1.1	1.1	1.0	1.2	0.9	1.2	0.0	0.9	1.2	0.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.5	0.2	1.2	-0.8	0.1	0.5	1.2	1.2	0.5	1.2	1.0	1.1	-0.2	1.1	0.0	0.7	1.1	1.0
Height	0.6	11.1	22.7	1.0	-0.2	-1.8	-3.0	1.0	-4.2	-4.4	-3.3	-3.4	-3.9	-4.3	-0.3	-4.3	-3.8	-4.2	-4.3	-4.8
Smoking Status	0.6	1.5	5.5	-2.0	-1.5	0.2	-2.3	-1.3	-1.4	-1.1	-0.8	-0.8	-1.2	-1.1	-0.5	-1.1	-1.3	-1.0	-1.2	-0.9
Maternal smoking around birth	0.6	0.8	2.6	-0.3	0.8	-0.0	-0.3	1.6	0.8	1.1	0.8	0.9	0.9	1.1	0.8	1.1	1.0	1.1	1.1	0.9
Medication: Atenolol	0.6	0.7	3.6	0.9	0.6	-1.4	1.9	-1.2	-0.6	-0.6	-0.2	-0.9	-0.7	-0.7	-0.6	-0.7	-0.3	0.8	-0.6	-0.3
Had menopause	0.6	0.8	2.2	-1.5	0.2	-0.3	1.3	-0.4	1.0	0.8	1.0	0.6	0.9	1.0	0.8	1.0	1.0	1.1	1.0	0.6
Weight	0.6	2.7	5.7	1.1	-0.1	-1.9	-1.1	1.3	1.5	1.8	2.4	2.2	1.7	1.9	2.3	1.9	1.9	1.3	1.9	1.1
Noisy workplace	0.6	0.7	3.7	-1.1	0.8	-0.1	0.0	-1.9	-0.9	-0.8	-1.0	0.1	-1.2	-0.9	-0.3	-0.9	-0.5	0.7	-0.8	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.2	-0.9	-0.5	0.4	-0.6	-0.4	-1.5	-1.3	-0.7	-1.1	-0.8	-1.2	-0.7	-1.2	-1.8	-0.1	-1.2	-0.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.8	0.4	-0.8	0.0	-0.5	0.9	1.1	0.9	0.6	1.0	1.3	0.9	1.1	0.9	0.1	1.4	1.0	1.2
Glaucoma (self-reported)	0.6	0.7	5.7	0.6	-0.7	-2.4	0.8	0.4	0.6	0.5	0.8	0.9	0.3	0.5	0.4	0.5	0.4	1.1	0.5	0.5
Age at first live birth	0.6	1.1	2.1	-1.0	0.6	-0.6	0.1	-0.3	-1.0	-1.3	-1.1	-1.1	-1.4	-1.4	-1.1	-1.4	-0.6	-1.4	-1.4	-1.4
Eye problems/disorders: None of the above	0.6	0.7	1.6	0.1	0.2	0.4	-1.0	-0.2	1.1	1.1	0.5	0.6	1.1	1.2	0.5	1.3	1.1	0.5	1.2	1.3
Medication: Blood pressure	0.6	1.0	3.2	0.5	-1.7	-0.2	-1.5	0.8	-0.8	-1.0	-0.4	-0.9	-0.8	-1.2	0.0	-1.2	-1.0	-1.8	-1.1	-0.8
Had major operations	0.6	0.7	4.1	-1.0	0.8	0.6	1.6	-2.0	0.4	0.4	-0.2	-0.3	-0.1	0.5	-1.1	0.4	0.6	1.0	0.4	0.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	3.0	1.5	1.4	0.0	1.7	-1.4	-0.5	-0.4	-1.1	-0.7	-0.7	-0.2	-1.5	-0.3	0.0	0.1	-0.3	0.1
Medication: Aspirin	0.6	0.8	2.7	0.4	-0.4	-0.8	-1.6	0.6	-0.9	-0.8	-0.7	-1.1	-0.8	-1.1	-0.5	-1.0	-0.3	-1.6	-1.0	-0.8
Loneliness, isolation	0.6	0.9	5.3	-0.6	-0.8	-2.3	-1.2	-1.7	-0.6	-0.6	-0.2	-0.4	-0.9	-0.5	-1.2	-0.5	-0.9	0.5	-0.5	-0.5
Commuting to job workplace: Walk	0.6	0.6	2.9	-1.7	-0.0	-0.6	-0.3	1.1	0.5	0.5	0.8	1.6	0.8	0.4	1.1	0.4	0.1	0.5	0.5	0.3
Commuting to job workplace: Public transport	0.6	0.7	3.6	1.5	0.1	-1.9	1.1	-0.7	0.1	0.2	0.0	0.8	-0.2	0.3	0.5	0.3	0.4	1.9	0.4	-0.2
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.5	-0.7	0.4	0.4	-0.6	-0.5	-1.1	-1.1	-1.1	-0.6	-0.5	-0.9	0.2	-0.9	-1.6	-0.7	-1.0	-1.2
Medication: Bendroflumethiazide	0.6	0.9	9.5	0.6	-3.1	-1.8	-1.1	-0.9	0.2	0.2	0.4	0.2	-0.2	0.1	0.5	0.1	-0.1	0.2	0.1	0.2
Schizophrenia (2018)	0.5	0.9	5.4	0.4	-2.3	0.9	-0.6	-0.3	-1.2	-1.1	-0.9	-0.5	-1.1	-0.9	0.0	-0.9	0.0	-0.3	-0.9	-1.5
Waist Hip Ratio (WHR)	0.5	2.1	4.5	-0.8	1.4	0.8	-1.5	-0.6	-1.4	-1.4	-1.6	-2.1	-1.8	-1.6	-1.6	-1.6	-1.2	-2.1	-1.7	-1.4
Average weekly spirits intake	0.5	0.7	6.4	0.4	2.5	1.1	0.4	0.2	0.1	0.3	-0.7	-0.4	0.1	0.2	-1.5	0.2	0.6	-0.7	0.1	0.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.0	-1.0	-0.8	-0.3	-0.3	0.5	0.8	0.8	1.4	0.6	1.0	0.8	0.8	0.8	0.2	1.0	0.9	0.6
Severe depression (siblings)	0.5	0.5	3.1	1.8	-0.7	0.9	0.5	0.4	-0.2	-0.7	-0.7	0.5	-0.1	-0.3	0.8	-0.3	-1.3	-0.6	-0.4	-0.5
Pack years adult smoking proportion	0.5	0.8	8.6	-0.4	0.6	-2.9	-1.6	0.0	0.3	0.4	0.8	0.7	0.5	0.4	0.4	0.4	0.7	0.1	0.4	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.6	0.2	-0.7	-1.7	1.3	-0.4	0.9	1.1	1.1	1.5	0.5	1.2	0.4	1.1	1.1	1.9	1.1	0.8
Number of incorrect matches in round	0.5	0.8	4.9	1.5	0.4	-0.2	0.7	2.2	0.2	0.3	0.3	1.4	0.7	0.3	1.4	0.3	-0.6	0.6	0.4	0.6
Past tobacco smoking	0.5	0.9	7.1	0.6	1.9	0.1	2.7	0.9	0.9	0.7	0.4	-0.1	0.5	0.6	-0.2	0.6	0.8	0.6	0.6	0.6
Pain all over the body in last month	0.5	0.5	2.0	-0.5	-1.3	-0.2	-0.5	-1.1	-0.2	-0.3	-1.1	-1.1	-0.5	-0.3	-1.4	-0.3	-0.5	0.3	-0.4	-0.1
Pulse rate	0.5	0.9	2.6	-1.3	-1.6	1.4	-1.5	-1.3	-0.5	-0.9	-0.6	-0.1	-0.7	-0.7	-0.4	-0.7	-1.4	-0.2	-0.7	-0.7
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.0	0.9	-0.2	-0.0	-1.2	-1.2	-1.1	-1.3	-1.1	-1.4	-1.4	-1.4	-0.3	-1.4	-1.4	-0.3	-1.3	-1.3
Mouth/teeth dental problems: Dentures	0.5	0.8	2.9	0.2	-0.9	0.2	-0.9	-0.0	-1.1	-1.0	-1.2	-0.4	-0.9	-1.1	-0.9	-1.0	-0.9	-1.7	-1.1	-0.8
Age at last live birth	0.5	0.7	1.8	-0.6	0.6	-0.7	1.4	0.5	-0.9	-1.0	-1.0	-0.7	-0.9	-1.0	-0.7	-1.0	-0.4	-0.6	-0.9	-1.3
Supplements: Vitamin C	0.5	0.6	2.1	0.2	-0.6	-1.4	0.8	0.6	0.8	0.8	1.3	0.6	0.8	0.7	0.8	0.7	0.8	0.6	0.7	0.2
Illnesses of siblings: Diabetes	0.5	0.7	4.0	-2.0	0.3	0.9	-2.0	0.8	-0.4	-0.1	-0.6	-0.5	-0.3	-0.3	-1.1	-0.2	0.2	-0.6	-0.2	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	4.2	-0.8	-0.1	-2.1	1.1	-0.1	-0.6	-0.3	-0.3	-0.2	-0.7	-0.6	-1.1	-0.6	0.3	-0.5	-0.6	-0.3
Breast cancer (self-reported)	0.5	0.7	2.1	0.2	0.5	-1.5	-0.0	-1.0	-0.7	-0.8	-0.4	-1.1	-0.9	-0.9	-0.7	-0.9	0.2	-1.2	-0.9	-0.9
Hearing aid user	0.5	0.6	3.8	-1.2	0.7	0.8	0.1	0.6	0.5	0.3	0.9	0.8	0.4	0.3	2.0	0.3	-0.3	1.2	0.4	-0.3
High cholesterol (Self-reported)	0.5	0.8	2.0	1.3	0.5	0.7	0.1	0.5	0.9	1.1	1.0	1.0	0.5	1.1	-0.0	1.0	1.1	1.4	1.1	1.2
Number of operations (self-reported)	0.5	0.7	7.6	-2.8	0.3	0.0	0.4	-1.6	-0.6	-0.5	-0.5	-0.4	-0.7	-0.5	-0.1	-0.5	-0.6	0.5	-0.5	0.0
Average weekly beer plus cider intake	0.5	0.7	4.2	0.4	-0.7	-0.2	-1.2	2.0	-0.8	-0.7	-0.4	0.3	-0.3	-0.5	1.6	-0.6	-1.4	0.1	-0.5	-0.3
Age started oral contraceptive pill	0.5	0.6	2.7	-1.6	0.1	-0.7	1.3	-0.3	-0.5	-0.4	-1.0	-0.3	-0.8	-0.6	-1.3	-0.6	-0.2	-0.6	-0.7	-0.0
Diastolic blood pressure, automated reading	0.5	1.6	2.9	1.1	-0.5	-0.7	-1.7	1.5	1.4	1.5	1.0	1.1	1.5	1.4	0.9	1.5	1.7	0.5	1.5	1.4
Pack years of smoking	0.5	0.7	8.4	-0.5	0.6	-2.9	-1.5	0.2	-0.1	0.2	0.4	0.4	0.3	0.0	0.1	0.0	0.4	-0.2	0.1	0.0
LDL Cholesterol	0.4	0.7	1.7	-0.8	-0.9	1.3	0.1	0.6	1.0	1.0	1.2	0.7	1.0	0.9	0.4	0.9	0.0	0.6	0.9	0.9
Blood Red Count	0.4	3.6	10.2	-2.1	1.4	0.3	1.2	-2.5	2.5	2.4	1.6	1.4	1.6	2.3	0.3	2.3	3.2	1.6	2.2	1.8
Angina	0.4	0.6	2.8	0.6	0.5	1.7	-0.1	-0.8	-0.8	-0.9	0.0	-0.6	-0.7	-0.9	0.5	-0.9	-0.6	-0.7	-0.9	-0.5
Diabetes (mother)	0.4	0.5	3.4	0.1	-1.8	0.2	-0.5	0.3	0.2	0.5	0.3	-0.4	0.4	0.4	-1.2	0.3	0.4	-0.2	0.2	1.4
Relative age voice broke	0.4	0.7	5.2	1.6	0.5	-0.6	1.1	-2.3	-0.2	-0.3	-0.8	-0.5	-0.5	-0.0	-0.9	-0.1	0.1	0.1	-0.2	-0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	2.8	0.3	-0.7	-1.7	-0.3	-1.2	-0.1	0.1	-0.4	0.1	-0.1	0.1	-1.2	0.0	0.7	-0.4	-0.1	0.8
Waist circumference	0.4	1.6	3.1	1.0	0.5	-1.8	-1.4	1.3	1.0	1.4	1.7	1.2	1.3	1.4	1.5	1.4	1.5	0.4	1.4	0.8
Financial difficulties in last 2 years	0.4	0.6	3.2	-1.1	-0.6	0.1	-1.8	0.7	-0.4	-0.4	0.8	0.6	-0.8	-0.7	1.1	-0.7	-0.3	-0.0	-0.6	-0.9
Allergy	0.4	1.0	2.1	0.5	-0.7	0.7	1.1	-0.1	1.3	1.2	0.7	0.6	1.4	1.4	0.8	1.4	0.6	1.0	1.4	1.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	4.5	1.6	0.8	-2.1	0.4	0.7	0.4	0.3	0.3	0.3	0.2	0.2	-0.1	0.2	0.6	0.0	0.2	-0.0
Medication: Simvastatin	0.4	0.6	2.3	0.9	-1.0	0.1	-0.9	0.6	0.6	0.6	1.1	1.5	0.5	0.4	1.2	0.4	0.4	0.8	0.5	0.5
Time employed in main current job	0.4	0.5	5.8	-0.1	0.3	0.4	-0.5	0.4	0.2	0.2	-1.1	-0.2	0.4	0.0	-2.4	0.0	0.6	-0.6	-0.1	0.8
Number of live births	0.4	0.5	3.8	-1.9	0.8	-0.3	0.5	1.4	-0.3	-0.3	-0.4	0.7	0.1	-0.3	-1.0	-0.2	0.2	-1.0	-0.3	-0.1
Pulse wave Arterial Stiffness index	0.4	0.4	1.6	-1.1	-0.3	-0.2	-1.1	-0.1	-0.4	-0.6	-0.3	0.1	-0.4	-0.7	0.6	-0.7	-1.3	-0.0	-0.6	-0.8
Breastfed as a baby	0.4	0.5	4.1	-0.5	0.3	-2.0	1.2	-0.8	0.5	0.6	1.2	0.0	0.3	0.3	-0.0	0.3	0.7	0.4	0.3	0.4
Birth weight of first child	0.4	0.8	1.5	1.0	1.2	1.2	0.8	-0.0	0.9	0.8	0.3	0.7	1.1	1.1	0.6	1.1	0.8	0.9	1.1	0.9
Pulse wave reflection index	0.4	0.5	5.6	0.0	-0.2	-2.4	-0.1	0.7	-0.4	-0.5	-0.5	0.1	0.1	-0.6	0.3	-0.5	-0.5	-0.6	-0.6	0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	3.6	0.1	-0.2	-1.1	-1.9	-0.7	-0.3	-0.5	-0.6	-1.0	-0.6	-0.6	-0.9	-0.6	-0.5	-1.3	-0.6	-0.8
Gout (self-reported)	0.4	0.6	1.8	0.8	0.6	-0.6	0.1	-0.1	0.9	0.8	0.7	1.3	0.4	0.7	0.9	0.7	1.1	1.3	0.8	0.4
Forced vital capacity (FVC), Best measure	0.4	1.5	5.8	0.4	0.5	0.7	0.6	-0.9	-1.3	-1.5	-1.2	-1.6	-1.7	-1.4	-0.6	-1.4	-1.0	-0.6	-1.4	-2.4
Exposure to tobacco smoke outside home	0.4	0.5	2.5	-0.4	-1.6	-0.4	-1.5	0.0	-0.3	-0.4	-0.2	0.0	-0.5	-0.3	1.1	-0.3	-0.2	-1.0	-0.3	-1.1
Shortness of breath walking on level ground	0.4	0.4	2.1	0.6	0.2	0.3	-1.4	1.2	-0.5	-0.4	0.1	0.5	0.2	-0.4	1.0	-0.3	-1.0	-0.8	-0.4	-0.2
Medication: Allopurinol	0.4	0.5	1.8	0.7	-1.2	-1.1	-0.2	-0.1	0.7	0.7	0.4	1.4	0.2	0.7	0.7	0.6	0.8	0.9	0.6	0.5
Family relationship satisfaction	0.4	0.5	2.5	1.1	0.7	-0.0	-1.6	0.9	-0.5	-0.5	0.0	-0.1	0.1	-0.4	1.6	-0.3	-0.7	0.2	-0.2	-0.4
Hypertension (Self-reported)	0.4	1.0	5.6	1.4	-1.9	-2.4	-1.4	0.9	0.3	0.4	1.3	0.2	0.5	0.4	1.1	0.4	0.4	-0.7	0.4	-0.0
Illnesses of father: Heart disease	0.4	0.5	4.2	-1.5	-0.5	1.3	-2.0	0.2	-0.1	-0.1	0.1	-0.1	0.0	0.1	0.5	0.0	-0.8	-0.3	-0.0	-0.1
Diabetes diagnosed by doctor	0.4	0.6	1.2	-0.8	0.8	-0.1	-0.0	-0.6	-1.0	-1.0	-1.0	-0.7	-1.0	-1.1	-0.6	-1.1	-0.8	-0.1	-1.0	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.7	-0.3	-0.4	-0.7	0.5	1.6	-0.6	-0.5	-1.2	-1.1	-0.3	-0.4	-0.9	-0.4	-0.6	-0.6	-0.5	-0.2
Osteoporosis (self-reported)	0.4	0.5	5.3	-2.3	0.7	-0.0	0.3	0.7	-0.2	-0.2	-0.6	0.2	0.7	-0.1	0.4	-0.1	-0.9	0.7	-0.0	0.4
Medication: Atorvastatin	0.4	0.5	1.6	-0.9	1.1	0.2	-0.6	-0.6	-0.9	-0.7	-0.1	-1.2	-0.9	-0.8	-0.6	-0.8	-0.4	-0.6	-0.8	-0.8
Risk taking	0.4	0.6	2.9	1.1	-0.2	-0.6	-1.0	-0.8	0.5	0.7	0.7	0.2	-0.3	0.5	-1.3	0.4	1.7	-0.4	0.4	0.3
Ever depressed for a whole week	0.4	0.5	1.8	-1.0	-0.2	1.1	-1.3	0.9	-0.3	-0.4	0.1	-0.2	-0.3	-0.7	-0.4	-0.7	-0.5	-1.3	-0.7	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	3.1	-1.8	-0.6	0.8	-1.7	-1.0	-0.2	-0.1	-0.3	0.3	-0.3	-0.1	-0.7	-0.1	-0.4	0.3	-0.2	-0.0
Basal cell carcinoma (self-reported)	0.4	0.5	2.2	-0.1	-1.3	-1.4	0.5	-1.2	-0.2	-0.1	-0.5	0.2	-0.1	0.1	-1.5	0.1	-0.0	-0.7	-0.1	0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.6	0.3	-0.6	-1.1	-1.1	1.1	0.0	0.0	0.2	-0.4	0.0	0.0	0.2	0.0	0.0	-1.2	0.0	-0.6
Worry (Nagel 2018)	0.3	0.7	2.6	-0.2	-1.4	0.4	-0.9	-0.8	-0.7	-0.8	-1.3	-1.0	-0.3	-0.3	-0.9	-0.3	-1.6	-0.0	-0.5	-0.6
Prostate Cancer	0.3	0.4	3.0	-1.7	-0.4	-1.5	-0.0	1.2	0.1	0.1	-0.2	-0.1	0.7	0.2	-0.0	0.2	0.3	-0.4	0.1	0.4
Crohns Disease (2012)	0.3	0.4	5.5	-0.5	0.0	-0.4	-2.3	0.7	0.4	0.4	0.3	-0.1	0.4	0.2	-0.8	0.2	0.0	-0.5	0.2	0.4
Lupus	0.3	0.5	1.3	1.0	0.6	-0.2	-0.8	0.3	0.9	0.8	0.4	1.1	0.8	0.6	1.0	0.6	0.6	0.4	0.7	0.6
Rheumatoid Arthritis	0.3	0.4	1.7	-0.2	0.0	-0.2	0.3	-1.3	-0.5	-0.7	-0.5	-0.7	-0.9	-0.4	0.2	-0.5	-0.5	-0.2	-0.5	-1.1
Schizophrenia (2014)	0.3	0.6	2.9	0.2	-1.7	0.5	-0.6	0.3	-1.1	-0.8	-0.7	-0.5	-1.1	-0.9	0.0	-0.9	0.0	-0.2	-0.8	-1.4
Ulcerative Colitis	0.3	0.4	1.8	-0.1	0.6	0.4	-1.2	0.2	0.8	0.5	0.8	1.3	0.5	0.5	0.6	0.5	0.0	0.4	0.6	0.2
Blood Platelet Count	0.3	3.6	20.6	-4.5	-1.8	-1.4	-1.8	-1.3	-2.0	-1.7	-1.7	-0.5	-1.5	-1.6	-2.9	-1.6	-2.0	-1.3	-1.7	-0.1
Systolic Blood Pressure	0.3	1.6	5.7	1.6	0.5	0.3	-1.4	2.4	1.3	1.3	1.0	1.0	1.4	1.2	1.9	1.3	1.1	1.1	1.3	1.1
Cardiovascular Disease	0.3	0.9	4.9	0.3	-1.8	-2.2	-2.0	0.3	0.3	0.4	0.9	0.7	0.5	0.5	0.4	0.6	0.3	-0.1	0.5	0.5
Hypothyroidism (self reported)	0.3	0.6	2.5	0.9	-1.4	-1.4	1.6	-0.4	-0.6	-0.5	-0.0	-0.7	-0.7	-0.8	-0.5	-0.8	-0.5	-0.4	-0.7	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	3.2	-1.2	-1.1	0.0	-0.1	-1.8	-0.3	-0.3	0.0	-0.2	-0.4	-0.1	-0.6	-0.1	-0.2	0.5	-0.2	0.1
Medication: Metformin	0.3	0.5	1.8	-0.4	-0.1	-1.3	-0.8	0.3	-0.8	-0.6	-0.4	-0.5	-0.9	-0.9	-0.7	-0.9	-0.6	0.5	-0.8	-0.1
Diabetes (father)	0.3	0.4	1.3	1.1	0.6	0.7	0.3	1.1	0.0	0.2	0.4	0.4	0.9	0.6	0.3	0.6	-0.3	0.6	0.5	0.7
Age when periods started (menarche)	0.3	0.8	2.3	-0.8	-1.5	0.6	-0.7	0.0	-0.8	-0.7	-1.4	-1.3	-0.6	-0.7	-1.4	-0.7	-0.3	-1.5	-0.8	-0.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.9	1.4	0.3	-1.4	0.0	-0.2	0.5	0.4	0.5	0.4	0.4	0.3	-0.1	0.3	0.2	-0.5	0.3	0.5
High blood pressure	0.3	0.9	4.9	1.2	-2.0	-2.2	-1.3	1.0	0.3	0.3	1.2	-0.0	0.5	0.3	1.1	0.4	0.3	-0.7	0.4	-0.2
Hair/balding pattern: Pattern 2	0.3	0.4	3.1	-0.4	-1.1	-0.6	-0.1	1.8	-0.2	-0.0	-0.4	0.4	-0.0	-0.2	0.5	-0.2	-0.8	-0.0	-0.2	0.3
Forced vital capacity (FVC)	0.3	1.1	4.4	0.1	0.1	-0.5	-0.6	0.2	-1.2	-1.3	-0.8	-1.6	-1.2	-1.3	-0.5	-1.3	-0.8	-1.1	-1.3	-2.1
Qualifications: None of the above	0.3	0.7	2.3	0.7	-0.7	-0.1	0.5	1.4	0.6	0.8	0.5	1.5	0.8	0.7	1.3	0.7	0.6	1.0	0.8	0.5
Diabetes (self-reported)	0.3	0.5	1.2	-1.1	-0.0	-0.2	-0.1	0.3	-1.0	-1.0	-0.5	-0.5	-0.9	-1.1	-0.4	-1.1	-0.8	-0.4	-1.0	-0.6
Illnesses of siblings	0.3	0.4	2.4	1.2	0.4	-1.0	1.5	-0.2	0.2	-0.1	-0.3	0.3	-0.2	-0.2	-0.7	-0.2	0.0	-0.9	-0.3	0.5
Impedance of arm (right)	0.3	1.2	4.7	-0.1	-0.4	2.2	-0.9	-0.6	-1.0	-1.1	-1.8	-0.8	-0.8	-1.2	-1.0	-1.1	-1.7	-0.8	-1.2	-0.4
Alcohol intake versus 10 years previously	0.3	0.5	3.3	0.5	-1.0	-1.0	0.6	-1.8	0.2	0.0	0.4	0.7	-0.7	0.0	0.1	-0.0	0.6	0.8	0.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.0	0.9	0.2	-0.1	-0.7	0.7	-0.8	-1.1	-0.7	-1.4	-0.9	-1.3	-0.5	-1.2	-0.5	-1.2	-1.2	-1.4
Prospective memory result	0.3	0.3	5.3	2.3	-0.1	0.2	-0.1	-0.4	-0.1	0.0	-0.6	-0.0	0.3	0.1	-0.3	0.1	0.2	-0.3	0.1	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.4	1.1	0.6	0.9	0.7	-0.4	-0.8	-1.1	-0.9	-1.2	-1.1	-1.1	-0.4	-1.1	-0.6	-0.5	-1.0	-1.6
Impedance of arm (left)	0.3	1.3	5.8	-0.3	-0.3	2.4	-0.6	-0.5	-1.0	-1.2	-1.8	-0.8	-0.9	-1.1	-0.8	-1.1	-1.8	-1.1	-1.1	-0.8
Hair/balding pattern: Pattern 4	0.3	0.8	2.2	-0.6	-0.7	-1.5	0.7	-0.7	-1.0	-1.1	-0.4	-0.8	-0.8	-1.2	-0.6	-1.2	-0.9	-0.6	-1.1	-1.0
Loud music exposure frequency	0.3	0.4	3.4	1.2	0.7	-0.1	-1.9	-0.2	0.2	0.0	0.1	0.4	0.5	-0.0	0.2	0.0	-0.2	-0.0	0.1	0.6
Headache pain in last month	0.3	0.5	2.8	-1.2	-0.7	1.3	-0.5	-1.7	-0.1	-0.1	-0.1	-0.2	-0.7	0.1	-1.1	0.0	-0.4	0.3	-0.1	-0.4
Medication: Amlodipine	0.3	0.4	1.0	0.9	-1.0	0.0	-0.1	-0.3	-0.5	-0.6	-0.8	-0.8	-0.5	-0.5	-0.4	-0.5	-0.6	-0.9	-0.6	-0.6
High blood pressure (siblings)	0.3	0.4	1.8	-0.1	-0.2	0.3	-1.3	-0.4	-0.8	-0.5	-0.0	-1.1	-0.1	-0.3	0.7	-0.3	-0.7	0.1	-0.3	-1.1
Arm fat-free mass (right)	0.3	1.4	6.9	1.2	0.0	-2.6	-0.5	1.4	0.6	0.7	1.8	1.0	0.8	0.9	2.0	0.9	1.1	0.4	0.9	0.2
Number of full brothers	0.3	0.3	1.4	-0.9	0.0	-1.1	-0.3	0.6	-0.5	-0.4	-0.7	0.5	-0.2	-0.2	-0.3	-0.2	-0.9	1.2	-0.2	-0.2
Wheeze or whistling in the chest in last year	0.3	0.5	4.5	0.2	-1.0	-2.1	-0.9	-0.6	-0.1	0.1	0.1	-0.4	-0.1	0.0	-1.1	0.0	0.4	-0.3	-0.1	0.1
Pulse wave peak to peak time	0.3	0.4	1.6	1.1	0.3	0.2	1.1	0.3	0.4	0.6	0.3	-0.1	0.3	0.6	-0.6	0.6	1.3	-0.0	0.5	0.7
Angina (self-reported)	0.3	0.4	1.6	0.4	0.8	1.3	0.0	-0.7	-0.5	-0.7	0.3	-0.5	-0.6	-0.7	0.7	-0.7	-0.5	-0.6	-0.7	-0.5
Migraine (self-reported)	0.3	0.4	3.2	-0.6	-0.6	0.9	1.1	-0.3	-0.2	-0.1	-0.6	-0.7	-0.2	0.0	-1.8	0.0	0.0	-0.4	-0.1	0.3
Arm predicted mass (right)	0.3	1.3	5.8	1.1	0.2	-2.4	-0.5	1.4	0.6	0.8	1.9	0.9	0.9	0.9	2.1	0.9	1.0	0.3	0.9	0.1
Number of full sisters	0.3	0.4	1.0	0.1	1.0	0.8	-0.9	0.9	-0.5	-0.4	0.3	0.2	-0.3	-0.7	0.8	-0.6	-0.6	-0.9	-0.5	-0.3
Leg pain on walking	0.3	0.4	2.7	-0.8	-1.6	-0.0	0.1	0.8	-0.4	-0.4	0.2	0.7	-0.4	-0.4	0.8	-0.4	-0.8	-0.0	-0.3	-0.9
Smoking status: Previous	0.3	0.4	4.3	0.1	-1.1	0.8	-2.1	-0.6	-0.4	-0.2	0.2	0.6	-0.0	-0.0	0.6	-0.0	-0.4	-0.3	-0.0	-0.3
Qualifications: nursing, teaching	0.3	0.5	3.2	-0.6	1.8	0.7	0.0	-1.4	-0.2	-0.1	-0.5	-0.7	-0.5	-0.0	-1.4	-0.1	0.4	0.2	-0.1	0.3
Asthma (self-reported)	0.3	0.6	2.1	-1.0	-0.7	-0.3	0.5	-1.0	0.6	0.8	0.9	0.8	0.2	0.8	-0.3	0.8	1.5	1.0	0.8	0.5
Medication: Aspirin	0.3	0.4	2.7	0.2	-0.7	-1.2	-1.6	0.5	-0.5	-0.4	-0.2	-0.5	-0.3	-0.5	-0.2	-0.5	0.0	-0.9	-0.5	-0.3
Average weekly champagne plus white wine intake	0.3	0.4	2.5	1.1	0.3	-1.6	-0.2	0.6	0.5	0.5	0.4	0.4	0.5	0.5	0.1	0.6	0.7	-0.5	0.5	0.1
Medication: Paracetamol	0.3	0.4	2.3	-1.5	-0.7	-0.6	-0.6	-0.5	-0.4	-0.5	-0.5	0.1	-0.4	-0.3	-1.5	-0.3	-0.5	-0.5	-0.4	-0.3
Medication: Lisinopril	0.3	0.4	1.5	-0.2	0.3	-0.0	-0.4	1.2	0.9	0.9	0.8	0.0	1.1	0.7	0.3	0.7	0.6	0.2	0.8	0.7
Ever smoked	0.3	0.6	3.0	-1.0	-1.6	-1.2	-1.5	-1.7	-0.4	-0.1	-0.3	-0.3	-0.0	0.0	-0.3	-0.0	-0.2	-0.1	-0.1	0.2
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.7	-1.2	1.8	1.9	1.6	-1.2	0.2	0.1	-0.8	0.1	-0.3	0.1	-1.1	0.1	0.1	1.2	0.1	0.4
Irritable Bowel Disease (IBD)	0.2	0.4	1.9	0.1	1.4	-0.4	-1.2	0.6	0.6	0.6	0.4	1.0	0.6	0.3	-0.3	0.4	0.5	0.4	0.4	0.5
Mean Putamen Volume	0.2	0.2	1.3	-1.1	1.0	0.1	-0.0	0.1	0.2	0.3	0.1	-0.1	0.3	0.2	-1.1	0.2	0.6	-0.2	0.2	0.5
Neuroticism (2016)	0.2	0.3	1.0	-0.3	1.0	0.7	-0.3	-0.3	-0.5	-0.6	-0.6	-0.4	-0.6	-0.5	-0.5	-0.5	-0.2	0.1	-0.4	-0.7
Primary Biliary Cirrhosis	0.2	0.3	2.9	0.6	-0.9	1.7	0.8	-0.9	-0.1	-0.2	0.1	0.4	-0.2	-0.2	0.1	-0.2	0.2	0.1	-0.2	0.1
Blood Eosinophil Count	0.2	1.8	4.8	-0.9	0.8	-0.7	-1.7	1.6	-1.7	-1.5	-1.4	-0.3	-1.1	-1.7	-0.3	-1.6	-1.5	-2.2	-1.6	-1.5
Chronotype (morning person)	0.2	0.5	3.3	0.5	-0.5	1.5	-1.8	0.5	-0.3	-0.4	-0.3	-0.1	-0.1	-0.4	1.0	-0.4	-0.8	-0.7	-0.4	-0.4
Sensitivity / hurt feelings	0.2	0.4	2.5	-0.7	-0.5	0.0	-1.6	1.2	-0.5	-0.3	-0.8	-0.3	0.2	-0.4	-0.6	-0.3	-0.8	0.0	-0.3	0.4
Impedance of leg (right)	0.2	0.8	4.2	-0.7	-2.0	0.9	-1.1	0.8	-0.6	-0.7	-1.2	-0.6	-0.4	-0.6	-1.1	-0.6	-1.0	-1.3	-0.7	0.2
Townsend deprivation index at recruitment	0.2	0.3	1.0	1.0	0.4	-0.4	-0.2	-0.2	-0.3	-0.3	0.1	0.8	-0.6	-0.2	1.0	-0.2	0.1	-0.3	-0.1	-0.9
Hayfever, allergic rhinitis or eczema	0.2	0.3	2.0	1.4	0.8	-0.8	0.4	-0.6	-0.4	-0.4	-0.2	-0.2	-0.6	-0.5	-0.7	-0.5	0.4	-0.2	-0.5	-0.5
Medication: Levothyroxine sodium	0.2	0.3	1.2	0.1	-0.8	-0.6	1.1	1.1	-0.5	-0.3	-0.4	-0.5	-0.2	-0.4	-0.3	-0.4	-0.4	-0.6	-0.4	-0.1
Sitting height	0.2	1.3	3.5	-0.3	-1.2	-0.8	-1.9	1.8	-1.0	-1.2	0.2	0.2	-0.5	-1.2	1.8	-1.2	-1.4	-0.6	-1.0	-1.5
Chronic bronchitis/emphysema (father)	0.2	0.3	1.1	0.3	-0.9	-0.1	-1.1	1.0	0.6	0.3	0.4	0.3	0.4	0.0	-0.1	0.1	0.3	-0.9	0.1	0.1
Hearing difficulty/problems with background noise	0.2	0.4	1.4	1.0	-0.7	-0.2	0.4	-0.1	0.6	0.5	0.9	-0.3	0.3	0.3	1.0	0.3	0.5	1.2	0.4	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	2.1	0.4	-0.8	-1.4	0.3	-1.4	-0.1	0.1	0.2	0.6	-0.4	0.3	-0.3	0.2	0.2	1.1	0.2	-0.1
Heart attack	0.2	0.3	1.2	1.0	0.5	-0.7	-0.7	0.9	-0.5	-0.3	-0.3	-0.2	-0.3	-0.5	0.5	-0.4	-0.2	-1.1	-0.4	-0.2
Worrier / anxious feelings	0.2	0.4	1.2	-0.6	-1.1	0.2	-0.4	-1.0	-0.4	-0.7	-1.0	-0.6	-0.6	-0.6	-0.9	-0.6	-0.8	-0.1	-0.6	-0.2
Asthma	0.2	0.5	1.9	-1.2	-0.5	-0.5	0.5	-1.0	0.4	0.6	0.7	0.8	-0.1	0.5	-0.6	0.5	1.4	0.7	0.5	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.9	0.1	-0.9	-0.5	-0.0	-0.8	0.0	0.2	0.6	0.9	0.1	0.3	-0.2	0.3	0.3	0.5	0.3	0.1
Medication: Cholesterol lowering	0.2	0.2	1.2	-0.1	0.1	-0.0	0.1	0.6	0.2	0.3	0.9	0.9	0.1	0.1	1.1	0.1	0.3	0.8	0.2	0.4
Medication: Lansoprazole	0.2	0.3	1.3	0.4	1.1	0.6	-0.8	0.6	-0.4	-0.4	-0.1	-0.1	-0.3	-0.4	-0.2	-0.3	-0.4	-0.9	-0.4	-0.3
Peak expiratory flow (PEF)	0.2	0.5	3.2	0.1	0.1	1.6	-1.8	1.6	0.0	-0.1	0.5	0.5	0.3	-0.4	0.6	-0.3	-0.1	-0.1	-0.2	0.0
Medication: Paracetamol	0.2	0.3	1.9	-1.3	-0.5	-1.1	-0.2	-0.9	0.0	-0.1	-0.2	0.3	-0.3	0.2	-1.4	0.1	-0.0	0.1	0.0	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	0.1	0.9	0.3	0.5	-0.7	0.5	0.7	0.0	0.3	0.6	0.8	-0.2	0.8	0.7	0.6	0.7	0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.5	-0.2	-1.2	-1.1	0.7	0.2	-0.4	-0.2	0.0	-1.0	-0.3	-0.5	-0.6	-0.5	-0.4	-0.6	-0.4	-0.0
Birth weight	0.2	0.4	2.3	0.9	1.5	0.2	0.1	1.0	0.1	0.4	0.1	1.0	0.3	0.2	1.2	0.2	0.7	0.4	0.3	0.2
Qualifications: College or University degree	0.2	0.6	7.0	-0.3	0.0	-0.2	0.6	-2.7	-0.2	-0.2	-0.3	-1.0	-0.7	-0.1	-1.1	-0.1	0.3	0.6	-0.2	-0.3
Medication: Seretide 50 evohaler	0.2	0.3	1.9	-0.3	-1.4	-0.0	-0.4	0.1	0.6	0.5	0.7	0.1	0.2	0.4	-0.5	0.4	0.5	0.3	0.4	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.8	-0.4	-0.8	-0.7	-0.0	0.7	-0.0	-0.0	-0.4	0.1	0.3	-0.0	-0.8	0.0	-0.1	0.2	-0.0	0.9
Pulse rate, automated reading	0.2	0.7	4.6	-0.4	-2.1	0.7	-1.5	-0.7	-0.1	-0.4	-0.7	-0.4	-0.3	-0.4	-1.3	-0.3	-0.2	-1.4	-0.4	-0.5
Alcohol intake frequency.	0.2	0.4	2.2	-1.5	0.5	-1.0	0.7	-1.3	-0.2	-0.1	-0.1	-0.6	-0.3	0.1	-0.7	0.1	0.2	0.8	0.1	-0.0
Comparative height size at age 10	0.2	1.1	8.0	1.0	2.2	-0.2	-0.1	1.7	0.4	0.2	1.1	1.1	0.3	0.0	2.8	0.1	0.4	-0.5	0.2	-0.6
Chest pain or discomfort	0.2	0.3	1.5	-0.7	0.2	1.1	-0.1	-1.2	0.0	-0.1	0.8	-0.4	-0.6	-0.0	0.3	-0.0	0.3	-0.1	-0.0	-1.2
Average weekly red wine intake	0.2	0.4	2.1	-0.0	0.5	0.3	-1.4	-0.4	-0.3	-0.3	-0.1	-0.8	-0.2	-0.6	-0.6	-0.6	-0.4	-1.0	-0.5	-0.7
Handedness (chirality/laterality): Left-handed	0.2	0.3	2.2	0.7	-0.8	-0.5	0.6	-0.6	0.1	0.1	-0.2	-0.5	-0.1	-0.0	0.3	-0.1	0.1	1.5	0.1	0.2
Friendships satisfaction	0.2	0.2	1.3	0.3	0.7	0.0	0.1	1.2	-0.0	0.1	0.9	0.3	0.5	0.0	0.6	0.1	-0.0	0.1	0.1	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	2.8	1.7	-0.1	-0.7	0.4	0.1	0.4	0.3	0.1	0.0	0.7	0.4	0.9	0.4	-0.3	0.5	0.3	0.6
Back pain experienced in last month	0.2	0.3	1.4	-0.2	1.2	0.7	-1.1	-0.5	-0.2	-0.2	-0.3	-0.0	0.0	0.1	0.9	0.0	-0.7	0.7	-0.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	4.2	1.0	0.2	2.0	-1.0	-0.2	-0.2	-0.3	0.1	-0.2	-0.4	-0.4	0.3	-0.4	-0.2	-0.7	-0.3	-0.8
Financial situation satisfaction	0.2	0.2	1.4	1.1	0.0	0.9	-0.2	-0.3	-0.1	-0.3	0.0	0.5	0.3	0.0	1.2	0.0	-0.4	0.5	0.1	-0.3
Basal metabolic rate	0.2	1.1	4.4	1.2	0.4	-2.1	-0.8	1.4	0.5	0.7	1.6	0.9	0.8	0.8	2.0	0.8	0.9	0.5	0.8	0.1
Arm fat-free mass (left)	0.2	1.1	6.2	1.0	0.0	-2.5	-1.0	1.3	0.6	0.7	1.6	0.7	0.8	0.8	1.5	0.8	1.1	0.2	0.8	0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.6	1.3	0.5	-0.7	-0.6	1.0	-0.3	-0.1	-0.1	0.0	-0.2	-0.3	0.5	-0.3	-0.1	-1.0	-0.3	-0.0
Impedance of whole body	0.2	0.9	4.0	-0.2	-1.2	2.0	-0.8	0.3	-0.6	-0.7	-1.4	-0.4	-0.5	-0.8	-1.1	-0.8	-1.2	-1.5	-0.8	-0.1
Arm predicted mass (left)	0.2	1.3	5.8	1.2	0.2	-2.4	-1.0	1.5	0.6	0.8	1.7	0.9	0.9	0.9	1.7	0.9	1.1	0.1	0.9	0.4
Crohns Disease (2017)	0.1	0.3	1.4	0.8	1.2	-0.4	-1.0	0.4	0.6	0.6	0.5	0.2	0.4	0.3	-0.5	0.3	0.4	0.2	0.4	0.6
Ulcerative Colitis (UC)	0.1	0.1	0.8	-0.7	0.8	-0.2	-0.6	0.3	0.2	0.1	-0.2	0.9	0.2	0.0	-0.1	0.1	0.3	0.1	0.1	-0.1
Breast Cancer	0.1	0.2	0.8	0.5	-0.3	0.1	-0.9	0.8	-0.4	-0.3	0.1	-0.3	0.3	-0.2	0.6	-0.2	0.1	-0.7	-0.2	-0.2
Bipolar Disorder (2011)	0.1	0.1	0.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.4	0.0	0.4	-0.1	0.0	0.5	-0.0	-0.7
Heel T-Score	0.1	0.8	3.2	-1.0	0.5	0.9	0.2	-1.8	0.6	0.9	1.2	1.0	0.4	0.9	-0.2	0.8	1.1	1.0	0.8	0.8
Allergy or Eczema	0.1	0.2	1.5	0.7	1.2	-0.2	0.8	-0.0	-0.1	0.1	0.1	0.4	-0.3	-0.2	0.2	-0.2	0.6	0.3	-0.1	-0.2
Respiratory disease	0.1	0.2	0.9	-0.3	-0.6	-0.1	0.8	-1.0	-0.1	0.1	0.3	-0.7	-0.3	0.1	0.2	0.1	0.3	0.1	0.1	-0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.2	2.3	0.7	0.3	-1.5	-0.5	0.3	0.2	0.2	-0.1	0.1	0.1	0.1	-0.3	0.1	0.5	-0.3	0.0	0.2
Lung FEV1/FVC ratio	0.1	0.5	2.0	-0.9	-0.8	-0.7	-1.1	1.3	0.0	0.0	-0.9	0.7	0.5	0.0	-0.5	0.0	0.0	-0.1	-0.0	1.4
Tanning	0.1	1.1	5.6	0.7	-1.7	-0.5	-0.2	0.8	-1.1	-1.0	-0.6	-0.6	-0.9	-0.9	1.0	-0.9	-1.0	-2.4	-1.0	-1.5
Hand grip strength (left)	0.1	0.4	1.1	-0.2	0.5	0.4	-0.5	-0.2	-0.5	-0.7	-0.2	-0.9	-0.8	-0.8	0.2	-0.8	-1.0	0.2	-0.7	-1.1
Medication for hormone replacement therapy	0.1	0.1	1.0	-0.6	-0.2	-0.0	-0.0	-0.2	0.2	0.2	0.3	0.5	-0.3	0.1	0.5	0.1	0.1	1.0	0.2	-0.1
Leg fat-free mass (left)	0.1	0.7	3.4	1.1	0.6	-1.8	-0.7	0.6	0.2	0.4	1.2	0.6	0.5	0.5	1.8	0.5	0.6	0.7	0.6	-0.2
Impedance of leg (left)	0.1	0.5	3.4	-0.2	-1.8	1.2	-0.6	0.9	0.0	-0.1	-0.7	0.1	0.1	-0.2	-0.9	-0.1	-0.5	-1.2	-0.2	0.6
Leg predicted mass (left)	0.1	0.7	3.4	1.1	0.5	-1.8	-0.8	0.6	0.1	0.3	1.1	0.5	0.4	0.4	1.9	0.4	0.4	0.6	0.5	-0.3
Alcohol usually taken with meals	0.1	0.2	1.1	1.0	-0.7	-0.8	-0.8	-0.3	0.0	-0.2	-0.3	-0.2	-0.1	-0.2	0.1	-0.2	0.1	-0.2	-0.2	-0.6
Mouth/teeth dental problems	0.1	0.2	0.7	-0.7	0.8	-0.4	0.5	-0.8	0.2	0.1	0.6	-0.0	-0.6	-0.0	-0.4	-0.1	0.8	0.3	0.0	-0.0
Trunk fat-free mass	0.1	0.8	5.2	0.8	0.9	-2.3	-0.5	1.6	0.0	0.1	1.1	0.2	0.3	0.3	1.6	0.3	0.4	0.0	0.3	-0.5
Trunk predicted mass	0.1	0.7	5.1	0.9	1.0	-2.3	-0.5	1.4	-0.1	0.1	1.0	0.1	0.2	0.2	1.5	0.2	0.3	-0.1	0.2	-0.5
Standing height	0.1	1.4	3.4	0.2	0.2	-0.8	-1.0	1.3	-1.4	-1.4	-0.8	-1.0	-1.2	-1.5	1.0	-1.4	-1.4	-1.3	-1.4	-1.9
Medication: Ibuprofen	0.1	0.2	1.1	-0.2	-1.1	-0.1	-0.2	-1.0	-0.4	-0.2	0.2	0.5	-0.2	-0.1	-0.5	-0.1	-0.1	0.2	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	1.5	0.3	0.8	-0.5	1.2	-0.8	0.2	0.1	-0.2	-0.2	-0.3	0.3	-0.3	0.3	0.5	0.5	0.2	-0.1
Whole body fat-free mass	0.1	0.8	4.8	1.0	0.7	-2.2	-0.6	1.2	0.1	0.3	1.3	0.4	0.4	0.4	1.8	0.4	0.6	0.2	0.4	-0.4
Leg fat-free mass (right)	0.1	0.7	3.6	1.1	0.8	-1.6	-0.4	0.5	0.2	0.4	1.2	0.7	0.4	0.4	1.9	0.4	0.5	0.6	0.5	-0.3
Osteoarthritis (self-reported)	0.1	0.2	1.1	-0.0	0.3	1.0	0.1	-0.2	0.1	0.2	0.6	1.1	-0.1	0.0	0.2	0.0	0.4	0.1	0.1	0.4
Medication: Gliclazide	0.1	0.2	0.9	0.6	0.7	0.4	0.2	-0.6	0.1	0.1	0.0	-0.2	-0.5	0.0	0.3	-0.1	0.3	0.9	0.1	-0.1
Whole body water mass	0.1	0.7	4.2	1.0	0.6	-2.1	-0.6	1.0	0.1	0.2	1.2	0.3	0.3	0.3	1.8	0.3	0.5	0.1	0.3	-0.4
Leg predicted mass (right)	0.1	0.8	3.8	1.3	0.9	-1.6	-0.3	0.5	0.3	0.5	1.3	0.8	0.5	0.5	2.0	0.5	0.6	0.7	0.6	-0.3
Wears glasses or contact lenses	0.1	0.1	0.5	0.5	0.6	-0.6	-0.3	-0.3	0.3	0.4	0.7	0.1	-0.2	0.1	-0.0	0.0	0.4	0.5	0.2	0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.5	0.6	0.3	-0.2	0.1	-0.7	0.1	-0.1	0.2	-0.0	-0.5	-0.1	-0.6	-0.1	0.4	0.3	-0.1	-0.1
Illnesses of father: High blood pressure	0.1	0.1	0.5	0.3	-0.7	-0.5	-0.6	-0.2	-0.1	0.0	0.0	0.2	0.4	0.3	0.0	0.3	-0.0	-0.4	0.2	0.2
Ever had prostate specific antigen (PSA) test	0.1	0.2	1.4	-0.2	-0.0	1.2	-0.1	-0.6	0.5	0.3	0.3	0.1	-0.2	-0.0	0.2	-0.0	0.6	0.2	0.1	-0.4
Hair Pigment	0.0	1.3	4.2	0.8	0.1	-0.5	1.2	-0.2	1.4	1.3	1.3	0.7	0.9	1.4	0.5	1.4	1.7	2.0	1.4	1.1
Hand grip strength (right)	0.0	0.1	0.9	0.0	0.9	0.0	0.5	0.7	0.1	-0.1	0.1	-0.0	-0.0	-0.2	0.3	-0.2	0.0	0.2	-0.2	-0.0

Hub : Genes

GRAMD1A

Models

Trait associations