Hub : Genes

GRID1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2620	0.0990	6.6e-03	0.124	NA	0.086	NA	0.120	2.5e-07	NA	1.7e-05	NA	4.1e-07
2	GTEx	Artery Coronary	0.5130	0.1000	1.1e-04	0.017	NA	0.001	NA	0.043	8.7e-02	NA	3.0e-01	NA	1.4e-02
3	GTEx	Artery Tibial	0.1641	0.0507	2.2e-04	0.075	NA	0.058	NA	0.056	1.7e-06	NA	2.6e-05	NA	3.2e-05
4	GTEx	Nerve Tibial	0.1406	0.0504	3.1e-03	-0.003	NA	0.004	NA	-0.002	5.9e-01	NA	1.7e-01	NA	5.3e-01
5	GTEx	Stomach	0.2230	0.0840	9.7e-03	0.015	NA	0.016	NA	0.038	5.9e-02	NA	5.3e-02	NA	6.4e-03
6	ROSMAP	Brain Pre-frontal Cortex	0.1331	0.0324	1.2e-07	0.070	0.070	0.088	0.077	0.067	2.2e-09	2.5e-09	2.3e-11	4.2e-10	4.8e-09
7	TCGA	Breast Invasive Carcinoma	0.0940	0.0251	4.7e-07	0.045	0.033	0.029	NA	0.033	1.6e-09	2.2e-07	1.1e-06	NA	2.1e-07
8	TCGA	Colon Adenocarcinoma	0.1940	0.0780	9.8e-03	0.047	0.026	0.072	NA	0.077	9.9e-04	1.1e-02	5.8e-05	NA	3.1e-05
9	TCGA	Lung Adenocarcinoma	0.0520	0.0221	5.6e-03	0.016	0.013	0.015	NA	0.016	4.8e-03	1.0e-02	6.8e-03	NA	4.5e-03
10	TCGA	Lung Squamous Cell Carcinoma	0.0748	0.0322	6.0e-03	0.034	0.013	0.012	NA	0.023	8.7e-05	1.0e-02	1.3e-02	NA	9.7e-04
11	TCGA	Prostate Adenocarcinoma	0.1426	0.0525	1.3e-03	0.004	0.020	0.010	NA	0.009	1.2e-01	2.8e-03	2.8e-02	NA	3.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.5	0.7	2.4	0.7	0.6	1.5	0.6	-1.6	-0.0	0.5	0.5	-1.0	0.7	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.8	3.6	-0.6	-1.1	0.3	-0.1	-1.9	1.1	-0.5	-1.2	-0.5	-0.2	0.1
Depressed Affect (Nagel 2018)	1.4	3.0	6.2	-1.4	-1.0	-2.5	-1.7	0.2	-1.7	-1.7	-1.2	-2.5	-1.7	-1.9
Depression (Nagel 2018)	0.2	0.3	1.2	0.6	-0.5	-0.0	0.2	-1.1	-0.7	-0.1	0.1	-1.0	-0.2	-0.4
Intelligence (Savage-Jansen 2018)	0.7	2.3	6.5	-1.3	-2.0	-1.5	-2.5	-1.2	0.5	-1.5	-1.9	-0.3	-1.8	-0.7
Neuroticism (Nagel 2018)	0.5	1.1	2.7	-0.8	-1.3	-1.6	-0.8	-1.2	-1.0	-0.6	-0.5	-1.1	-0.7	-1.2
Schizophrenia (2018)	0.7	1.4	4.1	-1.1	-1.9	-0.8	-0.6	-1.4	1.5	-1.0	-2.0	0.2	-0.8	0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	2.5	-0.3	-0.3	0.5	-0.4	1.6	0.5	0.4	-0.0	0.5	0.1	0.6
Worry (Nagel 2018)	0.3	0.6	3.0	-0.2	-1.3	0.1	0.5	-1.7	-1.1	0.6	0.1	-0.0	0.5	0.1
Alzheimer’s Disease (in mother)	1.1	1.2	3.5	0.9	1.9	0.6	-0.3	1.0	-1.3	0.7	0.7	-1.3	1.0	1.5
Alzheimer’s Disease (in father)	1.6	1.7	6.7	0.7	0.3	1.6	2.6	-1.3	-0.8	0.8	0.9	-0.9	1.0	-1.8
Alzheimer’s Disease (including proxy)	0.9	1.3	3.5	1.2	1.6	1.3	0.7	0.1	-1.3	1.0	0.9	-1.9	1.2	-0.1
Crohns Disease (2017)	0.3	0.6	2.1	-0.7	-1.4	1.3	-0.1	0.2	-0.4	-0.1	-0.1	1.1	0.2	0.7
Irritable Bowel Disease (IBD)	0.5	1.2	4.2	-2.1	-2.0	0.1	-0.0	-1.4	0.2	-1.0	-0.9	0.9	-0.9	-0.2
Ulcerative Colitis (UC)	1.5	2.8	6.6	-2.6	-2.1	-1.3	-0.3	-2.5	0.8	-1.8	-1.8	0.6	-1.7	-1.3
Major Depression (MDD)	0.6	0.7	2.7	-0.5	-1.7	-1.1	-0.4	-0.3	0.7	-0.6	-0.8	-0.8	-0.2	-1.1
Reaction Time	0.3	0.6	2.4	-0.3	-0.7	-1.5	-0.6	0.4	0.8	-0.4	-0.1	0.5	-0.5	1.5
Verbal and Numeric Reasoning (VNR)	1.6	3.7	8.1	-1.8	-1.5	-2.2	-2.8	-2.3	-0.7	-2.1	-2.4	-1.1	-2.3	-0.8
Breast Cancer	1.0	2.4	5.3	2.3	1.8	-0.5	-0.2	1.2	-1.1	1.9	1.8	-1.1	1.7	2.1
Ovarian Cancer	2.3	3.1	7.5	-2.7	-0.9	-2.0	-0.8	0.4	-2.0	-2.5	-1.9	-0.9	-2.4	-0.7
Prostate Cancer	1.0	1.4	2.9	1.4	1.4	0.8	-0.6	1.0	1.7	1.2	1.2	0.2	1.1	1.5
Age at First Birth	0.8	1.1	5.9	0.2	-1.2	0.2	0.0	-2.4	0.9	1.1	0.2	0.7	1.0	-1.2
Bipolar Disorder (2011)	0.6	0.6	1.7	0.1	-0.6	-1.0	0.8	-1.3	0.7	-0.3	-0.3	-1.2	-0.3	-0.7
Body Mass Index (BMI) (2010)	1.7	2.3	5.5	-2.3	-0.4	-0.5	-1.7	2.0	-1.2	-2.0	-1.3	-0.2	-1.8	-1.4
Coronary Artery Disease (CAD)	0.8	1.0	3.2	-1.8	-0.9	-0.6	0.1	-1.2	-1.0	-1.4	-0.9	0.3	-1.1	-0.2
Crohns Disease (2012)	1.0	1.5	5.6	0.2	-1.3	2.4	2.1	0.7	-0.5	0.7	0.9	0.5	1.0	1.4
Mean Putamen Volume	0.3	0.4	1.8	-0.5	0.1	0.2	-0.3	1.3	-1.2	-0.2	-0.4	-0.2	-0.3	-0.5
Fasting Glucose	0.4	0.4	1.9	0.1	0.6	0.7	0.8	0.2	-1.4	-0.5	-0.5	0.2	-0.7	0.4
HbA1C	0.5	0.6	2.9	-0.3	0.4	0.6	0.6	0.9	0.8	0.2	0.6	1.7	0.5	-0.6
HDL Cholesterol	0.3	0.5	1.5	-0.2	-1.1	-0.3	-1.1	-0.4	0.5	-0.1	-0.7	1.2	-0.0	0.1
LDL Cholesterol	0.7	1.0	3.4	-0.5	0.9	-1.1	-1.8	-0.8	0.4	-0.8	-0.5	-1.2	-1.0	-1.3
Lupus	0.7	1.0	2.6	0.6	-0.1	0.6	0.0	0.6	0.8	1.2	1.5	1.3	1.4	1.6
Neuroticism (2016)	0.4	0.5	1.7	-0.0	-0.9	-1.3	-0.4	-0.5	-1.0	-0.5	-0.5	-1.1	-0.4	-0.5
Primary Biliary Cirrhosis	0.6	0.9	2.3	0.2	0.9	1.5	0.8	-0.9	0.1	0.9	1.0	1.0	0.6	1.4
Rheumatoid Arthritis	0.6	0.8	1.7	-0.8	-0.3	-1.2	-1.3	-0.1	-0.0	-1.3	-1.0	-0.1	-1.1	1.1
Schizophrenia (2014)	0.6	1.2	3.2	-1.3	-1.6	-0.2	-0.9	-1.7	0.8	-0.9	-1.8	-0.5	-0.6	-0.3
Triglycerides	1.2	1.9	7.3	-1.6	-0.0	-1.6	-0.3	0.2	-2.2	-1.2	-0.2	-2.7	-1.4	-0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.4	0.1	0.7	0.4	0.9	-1.2	-0.4	-0.2	0.6	0.6	-0.4	0.4
Ulcerative Colitis	1.3	1.8	5.7	-2.4	-1.6	-0.1	0.1	-2.0	0.5	-1.1	-1.0	1.5	-1.2	-1.2
Blood Eosinophil Count	0.2	1.6	3.1	1.7	1.0	1.2	0.4	0.8	0.4	1.7	1.2	0.5	1.7	1.8
Blood Platelet Count	0.1	1.3	4.5	-1.0	-1.0	-2.1	-0.9	-0.2	-1.1	-1.4	-0.5	-1.4	-0.9	0.5
Blood Red Count	0.1	0.8	5.3	-0.3	0.7	0.1	-2.3	0.0	-0.6	-0.2	-0.8	1.3	-0.2	-0.7
Blood White Count	0.1	1.0	4.5	-0.1	0.7	-0.0	0.4	-1.5	-2.1	-0.1	1.1	-1.1	0.5	-0.7
Heel T-Score	0.3	2.3	5.4	-2.1	-0.4	-0.1	-0.8	-2.0	-2.0	-1.8	-0.9	-0.4	-1.5	-2.3
BMI	2.9	16.9	32.6	-4.9	-3.4	-4.6	-4.7	3.5	-3.0	-5.7	-3.9	-1.0	-5.2	-3.3
Height	0.1	2.5	8.4	1.8	-0.4	1.1	2.0	2.0	-0.8	1.5	1.4	2.9	1.3	-0.0
Waist Hip Ratio (WHR)	0.1	0.4	1.6	-0.7	-1.2	0.3	0.4	0.9	-0.7	-0.8	-0.0	-0.6	-0.4	-0.3
Systolic Blood Pressure	0.1	0.6	2.6	0.9	0.3	0.7	-1.2	0.4	-0.6	0.3	0.4	-1.6	0.5	0.8
Smoking Status	1.3	3.0	11.8	-1.1	-0.7	-1.3	-3.4	-3.2	0.8	-0.6	-0.5	-0.7	-0.5	-2.3
Allergy or Eczema	0.1	0.4	1.5	0.8	-0.7	1.2	0.0	0.4	-0.5	0.3	0.4	0.8	0.1	0.1
Cardiovascular Disease	0.1	0.4	1.5	0.1	0.1	1.1	0.1	1.2	-0.8	-0.1	0.6	-0.4	0.2	-0.7
Hypothyroidism (self reported)	0.3	0.7	2.2	-0.3	1.0	-0.3	-0.3	1.4	-0.8	-0.2	-0.0	-1.5	-0.3	-1.4
Respiratory disease	0.8	1.7	3.2	-1.1	-1.7	-0.9	-0.4	1.8	-1.7	-1.6	-1.2	-1.2	-1.4	0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.0	-0.8	0.2	0.1	0.3	0.4	-0.0	-1.0	-0.1	-0.7	-0.6	-1.0
Lung FEV1/FVC ratio	0.2	0.9	4.0	0.8	-0.7	0.4	1.0	-0.5	-1.2	0.3	1.1	0.5	0.4	-2.0
Lung FVC	1.1	5.7	15.3	3.9	1.8	1.6	0.1	0.4	1.0	3.6	2.8	0.4	3.6	2.6
Neuroticism	0.3	0.7	2.6	-0.1	-0.4	-1.6	-0.9	-0.3	-1.6	-0.1	-0.1	-1.0	-0.2	-0.0
Chronotype (morning person)	2.3	5.3	12.8	-2.9	-2.7	0.8	1.6	-0.7	-3.0	-2.5	-1.8	0.4	-2.8	-3.6
Hair Pigment	0.0	0.4	3.0	-0.3	-0.4	-0.5	-0.8	-1.7	-0.4	-0.0	-0.4	-0.4	0.0	-0.3
Tanning	0.1	0.9	4.6	-0.3	-2.1	-0.9	-1.0	-0.2	-1.1	-0.4	0.0	-0.9	-0.6	-1.2
Hand grip strength (left)	1.1	3.0	6.3	2.4	0.5	2.2	0.4	1.9	-0.6	2.5	2.1	-0.4	2.4	1.0
Number of treatments/medications taken	0.8	1.4	5.5	-1.2	1.0	-1.0	-0.0	-0.2	-2.4	-1.1	-0.1	-1.7	-1.0	-0.9
Average weekly spirits intake	1.7	2.1	6.5	-1.0	0.3	-1.7	-1.3	-0.3	-2.6	-1.3	-0.6	-2.3	-1.2	-1.3
Sensitivity / hurt feelings	0.3	0.5	2.8	0.0	1.7	-0.7	0.5	-0.2	-0.2	0.3	0.7	0.7	0.4	0.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.9	0.3	1.3	-0.0	-0.3	-1.1	-0.7	0.3	0.2	-1.7	0.1	-0.3
Hearing difficulty/problems: Yes	1.3	2.0	6.5	-1.2	-1.3	-2.5	-1.6	0.4	0.1	-1.5	-0.7	-0.2	-1.6	-2.1
Relative age of first facial hair	0.5	1.1	4.2	2.1	0.8	0.0	0.5	-0.1	1.3	1.2	0.8	-0.6	1.1	1.4
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	7.7	0.3	1.1	0.6	-0.5	-2.3	1.9	0.9	-0.1	2.8	0.5	-0.4
Ever used hormone-replacement therapy (HRT)	2.3	3.0	4.8	-2.1	0.6	-1.6	-0.8	-1.9	-2.2	-1.7	-1.4	-1.6	-1.9	-2.1
Ever had hysterectomy (womb removed)	1.2	1.3	3.1	-1.1	-1.1	-1.8	-1.7	0.7	-0.3	-1.3	-1.2	-1.1	-1.1	-0.6
Systolic blood pressure, automated reading	1.3	3.9	10.3	-1.5	-1.8	-2.0	-3.2	1.3	-2.0	-2.1	-1.9	-2.0	-2.0	-1.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.8	0.4	0.8	-0.6	0.5	0.9	-0.1	0.2	0.8	0.1	-0.1	0.9
Angina	0.8	1.1	2.6	-0.4	0.4	-0.7	-0.8	-1.6	-1.1	-0.9	-1.0	-1.6	-1.0	-1.3
Medication for hormone replacement therapy	1.3	1.5	3.9	-2.0	-0.4	-1.5	-0.4	0.5	-0.5	-1.6	-1.8	0.7	-1.6	0.5
Vitamin and mineral supplements	0.7	0.9	3.3	0.7	1.5	0.6	0.1	0.1	1.1	1.0	0.4	0.7	0.8	1.8
Supplements: Zinc	0.3	0.3	1.5	-0.5	-0.3	0.1	-0.1	-0.1	1.2	-0.4	-0.3	0.3	-0.4	-1.1
Medication: Co-codamol	0.6	0.7	4.7	-0.3	-0.2	0.4	0.8	-1.0	-0.5	-0.2	0.6	-2.2	0.2	-0.8
Medication: Metformin	0.6	0.9	5.5	0.2	2.3	0.8	0.7	-0.3	0.9	0.6	1.1	-0.1	0.5	-0.0
Diabetes (father)	0.2	0.3	1.6	-0.2	-0.6	0.4	0.3	1.3	-0.7	-0.1	-0.1	0.4	0.0	0.7
Diabetes (mother)	1.1	1.3	4.2	1.6	1.0	0.8	1.1	-0.6	-0.3	1.1	1.7	2.0	0.9	0.2
Severe depression (siblings)	0.6	0.7	1.7	-0.6	-1.3	0.4	0.2	-0.9	-0.7	-1.1	-0.5	-1.1	-1.2	-0.2
Pack years adult smoking proportion	0.5	0.7	2.1	-1.3	-0.3	-1.0	-0.2	0.5	-0.5	-1.4	-0.4	-0.8	-1.2	-0.5
Impedance of leg (right)	0.7	3.2	9.3	1.5	0.5	1.2	1.8	-3.1	2.6	2.0	1.0	0.9	1.8	1.5
Leg fat-free mass (left)	0.6	3.4	7.9	-1.6	-1.2	-1.5	-1.8	2.8	-2.6	-2.0	-0.7	0.0	-1.8	-2.2
Trunk fat percentage	3.6	14.2	30.5	-4.6	-3.9	-4.5	-3.0	0.1	-2.7	-5.5	-3.8	-0.5	-5.3	-3.4
Hand grip strength (right)	2.4	6.5	15.0	3.4	2.4	2.7	1.4	1.6	-0.8	3.7	3.3	0.3	3.9	1.3
Townsend deprivation index at recruitment	0.9	1.3	6.5	-0.9	1.1	0.1	-0.6	-1.7	2.5	-0.5	-0.5	1.1	-0.3	-0.8
Current tobacco smoking	1.0	1.7	5.2	-1.4	-0.4	-0.9	-2.3	-1.9	1.0	-1.1	-0.9	-0.3	-1.0	-1.6
Average weekly fortified wine intake	0.9	1.0	5.1	-1.0	0.4	0.4	-0.9	-0.2	-2.3	-0.4	-0.5	-1.7	-0.6	-0.1
Maternal smoking around birth	0.3	0.4	1.3	-0.2	-1.0	-1.1	0.4	-0.4	-0.3	-0.5	0.2	-1.1	-0.1	-0.7
Fed-up feelings	0.7	1.2	4.1	-0.8	0.3	-1.1	-1.2	-0.4	-0.9	-1.1	-0.5	-1.4	-1.1	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.6	-0.1	-0.1	-0.2	-0.3	-0.8	0.1	-0.5	-0.3	-0.6	-0.5	-0.1
Relative age voice broke	1.4	2.1	7.0	2.6	0.7	1.1	2.0	-0.4	0.4	1.6	2.0	0.2	1.7	0.6
Taking other prescription medications	1.8	2.7	6.7	-2.0	-0.0	-1.5	-1.1	0.0	-1.2	-2.2	-1.5	-2.6	-2.4	-1.1
Age when periods started (menarche)	1.8	4.4	9.2	3.0	1.1	2.5	1.5	-1.2	1.5	2.9	1.8	0.4	2.8	2.5
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.4	-0.2	0.5	-1.9	-1.2	-0.1	-0.8	-0.9	-0.4	-1.8	-0.9	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	5.6	-0.5	0.3	-1.4	0.3	-2.4	-1.9	-1.3	-0.7	-1.9	-1.2	-1.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	2.2	-0.0	0.9	-0.3	-0.6	-0.9	1.5	0.2	-0.3	-0.7	0.0	0.4
Qualifications: CSEs or equivalent	1.0	1.3	8.5	-0.2	-0.2	0.4	-0.2	0.1	1.5	-0.2	-0.3	1.7	0.1	2.9
Serious illness, injury or assault to yourself	1.3	1.6	4.7	-2.2	-0.5	-1.5	-1.5	-0.2	-0.4	-1.6	-1.1	0.7	-1.9	-0.7
High blood pressure	0.5	1.3	4.2	-0.1	-0.4	0.6	-0.2	1.1	-2.1	-0.8	0.1	-1.9	-0.6	-1.9
Hayfever, allergic rhinitis or eczema	0.3	0.7	3.7	0.6	-1.1	1.6	0.2	0.3	0.4	0.2	0.2	1.9	-0.2	-0.2
Multivitamins +/- minerals	0.3	0.4	2.9	-0.1	-0.4	0.3	0.1	0.3	-0.8	-0.5	0.1	-0.3	-0.5	-1.7
Stomach or abdominal pain in last month	1.0	1.2	2.9	-1.3	-0.6	-0.3	-0.0	0.5	-1.6	-1.7	-1.2	-1.2	-1.5	-0.4
Supplements: Glucosamine	2.2	2.9	4.9	-1.9	-1.1	-2.0	-2.2	-1.1	-1.6	-2.0	-1.6	-0.8	-2.0	-1.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	3.1	-0.6	-0.2	-0.4	-1.0	-0.7	-1.8	-0.5	-0.3	-0.4	-0.7	-0.8
Medication: Atenolol	0.8	1.0	4.7	-0.1	-1.9	0.9	0.6	-0.6	-1.1	0.0	0.2	-2.2	0.2	-0.4
Medication: Levothyroxine sodium	0.2	0.3	1.8	-0.2	-0.0	0.6	0.3	1.3	-0.5	-0.5	-0.5	-0.4	-0.3	-0.6
Sitting height	0.5	3.2	8.2	2.9	1.9	1.5	0.1	0.8	1.7	2.6	1.7	1.8	2.2	0.8
Chronic bronchitis/emphysema (father)	0.2	0.3	1.1	-0.5	-0.2	-0.2	-0.1	0.7	0.2	-0.8	-0.3	-0.6	-0.5	-1.0
High blood pressure (mother)	0.7	1.0	4.4	-0.3	-1.0	-0.3	-2.1	0.1	-1.5	-0.6	-0.6	0.8	-0.8	-0.9
Body mass index (BMI)	3.3	14.1	26.1	-4.3	-2.4	-4.7	-3.9	1.6	-3.8	-5.1	-3.4	-1.8	-4.8	-3.5
Impedance of leg (left)	0.6	2.8	10.6	1.1	-0.6	1.1	1.9	-3.3	2.4	1.5	0.7	1.1	1.4	1.7
Leg predicted mass (left)	0.6	3.2	7.2	-1.6	-1.2	-1.5	-1.8	2.7	-2.4	-1.9	-0.7	0.1	-1.8	-2.2
Trunk fat mass	3.2	13.7	27.5	-4.3	-3.6	-4.5	-3.3	0.9	-3.2	-5.2	-3.5	-0.6	-5.0	-3.6
Waist circumference	3.2	11.9	20.9	-3.9	-3.4	-4.0	-3.5	2.0	-3.7	-4.6	-2.9	-1.2	-4.2	-3.0
Number of incorrect matches in round	0.8	1.4	4.6	-1.1	-0.9	-2.1	-1.0	1.3	-1.8	-1.0	-0.6	-0.5	-1.1	0.2
Past tobacco smoking	0.7	1.3	5.5	-0.4	0.2	0.9	2.3	2.3	0.7	-0.6	-0.4	0.7	-0.7	0.5
Alcohol usually taken with meals	0.6	1.0	6.0	0.1	-0.5	0.5	-0.7	1.6	0.5	0.5	-0.0	0.9	0.3	2.4
Nervous feelings	0.4	0.7	4.4	-0.8	-2.1	0.0	-0.4	-0.7	0.1	-0.4	-1.0	-0.3	-0.5	0.1
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.3	1.7	0.7	1.7	1.1	-0.6	0.5	1.7	1.4	-0.2	1.8	1.3
Hearing difficulty/problems with background noise	0.6	1.0	2.5	-1.0	0.2	-0.7	-0.9	-0.0	0.0	-1.2	-1.1	0.9	-1.6	-1.5
Hair/balding pattern: Pattern 2	0.4	0.5	1.4	0.9	0.8	0.1	0.5	-0.3	1.2	0.8	0.5	-0.3	0.7	0.5
Had menopause	1.3	1.6	5.6	-1.5	-0.5	-1.6	-2.4	0.3	-0.0	-1.4	-1.3	-0.5	-1.4	1.1
Had other major operations	1.1	1.3	4.4	-2.1	-1.6	-0.4	-0.2	1.5	-0.1	-1.3	-0.3	-0.9	-0.9	-1.3
Forced vital capacity (FVC)	1.7	6.4	15.6	4.0	1.8	2.8	1.7	0.3	-0.0	3.7	2.9	1.9	3.5	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.1	-0.5	0.0	-1.4	-0.4	-0.8	-1.5	-1.3	-0.8	-1.8	-1.3	-1.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.7	-0.5	-0.8	0.4	0.2	-0.0	-0.1	-0.3	0.4	-1.3	0.1	0.7
Qualifications: None of the above	1.8	3.8	8.6	-2.9	-0.9	-2.6	-1.3	0.5	-2.1	-2.5	-1.6	-2.0	-2.1	-1.3
Financial difficulties in last 2 years	1.0	1.3	3.3	1.2	0.0	1.8	0.6	-1.6	1.0	0.8	1.7	-0.4	0.9	-1.1
Mouth/teeth dental problems	2.4	3.7	9.9	-2.7	-1.4	-1.2	-1.0	-1.2	0.6	-2.9	-2.6	0.8	-3.1	-1.3
Heart attack	0.1	0.2	0.6	-0.4	-0.3	0.3	0.8	-0.5	0.3	-0.3	0.4	0.4	-0.2	-0.4
Allergy	0.7	1.6	3.6	1.2	1.8	0.2	0.7	-0.2	1.1	1.7	1.5	-0.9	1.9	1.1
Pain all over the body in last month	0.4	0.4	1.9	0.5	0.0	0.5	-0.3	-1.4	-0.7	0.7	0.5	0.2	0.8	-0.3
Diabetes (self-reported)	0.6	0.9	3.4	0.2	0.5	1.0	1.8	-0.3	-1.5	-0.1	1.3	-0.7	0.1	-0.6
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	5.9	2.2	2.0	1.9	0.3	-0.6	1.8	2.1	1.0	2.4	1.7	0.2
Medication: Ramipril	0.8	1.0	3.1	-1.0	0.3	-1.0	-0.4	-0.3	-1.8	-1.3	-1.0	-0.3	-1.3	-1.0
Medication: Simvastatin	1.6	2.4	5.7	-2.4	-0.8	-1.4	0.5	-0.4	-1.1	-2.3	-1.4	0.0	-2.0	-2.4
Fluid intelligence score	0.6	1.3	4.1	-0.7	-0.0	-1.5	-2.0	-1.5	0.6	-0.8	-1.3	-0.6	-1.3	-0.2
Illnesses of siblings	0.9	1.2	7.5	-0.8	-0.3	-1.8	-2.7	0.1	-0.5	-0.2	-0.9	0.7	-0.4	0.5
Neuroticism score	0.3	0.7	3.5	-0.9	0.1	-0.8	-0.9	-0.9	-1.9	-0.6	-0.3	-0.4	-0.6	-0.6
Weight	1.8	8.8	14.7	-3.0	-2.2	-3.7	-3.2	1.9	-3.4	-3.8	-2.3	-0.6	-3.6	-3.2
Impedance of arm (right)	0.6	2.8	9.3	0.4	-0.6	1.6	2.4	-3.0	2.2	0.6	0.5	2.5	0.5	0.7
Arm fat percentage (right)	3.9	15.4	32.8	-4.9	-3.3	-4.6	-3.3	0.5	-3.3	-5.7	-3.9	-0.6	-5.4	-3.8
Trunk fat-free mass	0.3	1.7	8.4	0.0	-0.0	-0.8	-1.7	2.9	-2.2	-0.1	0.4	-0.3	-0.1	-1.2
Hip circumference	2.2	9.5	15.8	-3.1	-3.1	-3.9	-3.0	1.3	-3.4	-4.0	-2.5	-0.6	-3.8	-3.3
Time employed in main current job	0.4	0.5	2.6	0.2	-0.3	-0.2	0.1	-1.1	1.6	0.0	-0.4	0.4	-0.2	-1.0
Alcohol intake versus 10 years previously	0.9	1.3	3.0	-1.4	-1.7	-0.5	-1.5	0.5	-1.4	-1.0	-1.5	1.0	-0.8	-0.6
Father’s age at death	0.9	1.2	4.2	-0.8	-1.4	-0.8	-0.3	0.9	-2.1	-0.5	-0.8	-0.9	-0.5	1.6
Worrier / anxious feelings	0.4	0.7	2.2	0.9	0.2	1.5	0.1	0.3	1.1	1.0	0.5	1.0	1.0	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	3.2	0.1	0.8	-0.8	-0.3	-0.8	0.5	-0.4	-0.6	1.8	-0.4	-0.5
Falls in the last year	0.9	1.2	2.7	-0.9	0.3	-1.2	-1.0	1.2	-1.3	-1.6	-0.4	-1.3	-1.5	0.1
Hair/balding pattern: Pattern 3	0.3	0.5	1.4	-0.9	-0.2	-0.2	-0.5	-0.1	-1.2	-0.9	-0.3	-0.5	-0.7	-0.9
Number of live births	0.6	0.8	3.0	0.6	1.7	0.2	1.3	0.1	-0.4	0.6	0.3	-1.7	0.7	0.1
Forced expiratory volume in 1-second (FEV1)	1.9	6.5	15.4	3.9	1.5	3.0	2.1	0.5	-0.2	3.7	3.0	2.1	3.5	1.1
Pulse rate	0.6	0.9	4.0	-0.9	-0.8	0.2	-1.6	0.6	2.0	0.1	0.1	1.0	0.3	1.1
Happiness	0.7	0.8	2.2	-0.7	-1.5	-0.7	-1.4	0.1	-0.4	-0.8	-0.8	-0.8	-1.0	0.8
Noisy workplace	0.9	1.1	3.8	-1.1	-0.8	-0.7	0.4	-1.0	-0.0	-1.6	-0.4	0.6	-1.3	-1.9
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.8	-0.3	-1.3	1.4	-0.0	-1.3	1.3	-0.1	-0.7	2.2	-0.4	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	3.5	0.1	-0.9	-0.1	0.4	1.9	0.1	-0.2	-0.1	0.1	-0.1	0.9
Mouth/teeth dental problems: Dentures	0.3	0.4	2.2	0.3	1.5	-0.2	-0.7	0.4	0.2	0.9	0.5	0.2	0.6	0.4
Asthma	1.8	3.5	7.6	-2.1	-1.9	-1.1	-1.8	1.2	-1.0	-2.8	-2.7	0.1	-2.8	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	4.0	-0.7	0.5	-0.7	-2.0	2.0	0.0	-0.5	-1.0	0.5	-0.6	-0.1
Medication: Cholesterol lowering	1.1	1.7	3.6	-1.8	-1.7	-0.7	0.6	0.5	0.7	-1.9	-0.9	0.3	-1.7	-1.9
Depression (self-reported)	0.6	0.7	3.6	-0.4	0.7	-0.2	1.4	0.0	-0.2	0.0	0.6	-1.9	0.1	1.0
Medication: Lansoprazole	1.4	1.6	5.1	-1.0	-0.3	-0.4	-0.6	-2.3	-1.0	-1.8	-1.3	0.1	-1.8	-1.3
Prospective memory result	1.4	1.7	4.1	-1.8	-0.8	-0.6	0.9	0.1	-1.4	-1.8	-0.6	-1.4	-1.5	-2.0
Lung cancer (father)	1.3	1.5	4.1	1.7	1.0	0.3	0.5	-0.7	-1.4	1.1	1.5	-2.0	1.1	-1.1
Illnesses of mother	1.2	1.4	11.5	0.3	-0.3	0.7	0.9	-0.2	3.4	0.7	-0.1	1.0	0.6	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.5	16.7	4.1	2.0	2.6	1.4	0.3	-0.2	3.7	3.5	1.4	3.6	1.0
Pulse wave Arterial Stiffness index	1.1	1.3	3.6	0.9	1.4	0.4	-1.9	0.5	1.3	1.1	1.1	0.6	0.9	1.5
Impedance of arm (left)	0.7	3.4	11.2	0.9	-0.5	1.7	2.4	-3.3	2.8	1.0	0.6	2.6	0.7	0.8
Arm fat mass (right)	3.6	15.0	29.6	-4.5	-3.2	-4.7	-3.8	1.3	-3.4	-5.4	-3.7	-1.0	-5.1	-3.8
Trunk predicted mass	0.3	1.7	8.5	-0.1	-0.2	-0.9	-1.8	2.9	-2.2	-0.2	0.3	-0.3	-0.1	-1.2
Standing height	0.3	2.9	6.6	2.4	0.3	1.5	1.4	0.8	0.7	2.3	2.1	2.6	2.1	0.3
Length of working week for main job	2.0	2.2	6.5	1.3	1.1	0.9	1.2	-2.1	2.5	1.0	0.8	2.4	1.0	0.4
Exposure to tobacco smoke at home	0.2	0.2	0.7	-0.5	0.6	0.1	-0.3	0.3	0.1	-0.8	-0.6	-0.1	-0.8	-0.1
Breastfed as a baby	1.0	1.2	2.2	-1.3	-0.6	-0.8	-0.0	-1.5	-0.5	-1.4	-0.8	-1.3	-1.2	-1.4
Tense / ‘highly strung’	0.8	1.3	7.1	-0.9	-1.3	0.1	1.4	-2.7	0.5	-0.2	-0.1	1.3	-0.5	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	4.0	6.4	-2.5	-1.6	-1.9	-1.5	0.3	-2.3	-2.5	-2.0	-2.2	-2.3	-1.9
Hair/balding pattern: Pattern 4	0.8	2.0	4.7	-2.1	-1.2	-1.5	-0.9	-1.0	-1.2	-1.5	-0.9	0.5	-1.4	-2.2
Birth weight of first child	0.2	0.4	1.6	0.6	-1.3	0.5	0.7	-0.9	-0.6	-0.2	-0.2	-0.2	-0.2	-0.8
Peak expiratory flow (PEF)	0.9	2.0	5.6	1.1	0.2	2.4	1.9	0.8	-1.1	1.2	1.5	1.6	1.0	-1.7
Pulse wave reflection index	0.3	0.4	2.2	-0.3	0.6	0.5	-0.9	-1.5	0.2	-0.2	-0.4	0.4	-0.2	0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	3.5	0.2	-0.1	0.2	1.2	-1.9	0.7	-0.4	-0.5	-0.3	-0.2	-0.7
Loud music exposure frequency	0.7	0.8	3.0	-0.5	0.2	0.6	0.1	1.4	-1.7	-0.1	-0.2	-1.4	-0.3	0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	2.2	-0.1	0.2	0.5	-0.1	-1.5	-0.0	-0.3	-0.5	0.4	-0.3	-1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.3	1.5	-0.9	0.4	0.9	0.8	0.1	0.7	0.9	0.2	1.0	0.3
Blood clot in the leg (DVT)	1.0	1.3	3.3	-1.0	1.4	-1.8	-1.2	-0.2	-1.1	-1.2	-0.8	-0.5	-1.1	-1.5
Medication: Paracetamol	1.1	1.8	5.7	-1.8	-0.4	-1.5	-0.2	0.0	-2.4	-1.6	-1.6	-1.0	-1.5	-0.5
Headache pain in last month	0.2	0.3	1.6	0.0	0.0	-0.5	-0.3	-0.6	-1.2	-0.0	-0.1	-0.5	0.2	-0.6
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.7	1.0	1.0	-0.1	-0.8	-1.2	-0.2	1.2	0.0	0.3	0.9	1.3
Glaucoma (self-reported)	0.2	0.2	0.9	-0.3	-0.1	0.1	-0.7	0.1	-0.9	-0.2	-0.3	-0.2	-0.5	-0.3
Gout (self-reported)	2.2	3.0	6.3	-2.5	-2.0	-2.0	0.2	-0.5	-0.2	-2.0	-1.6	-2.0	-2.1	-1.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.2	0.2	1.1	0.4	0.6	0.7	-1.1	-0.1	0.2	-1.5	-0.1	-1.2
Medication: Amlodipine	0.5	0.6	3.0	-0.8	-0.2	-0.0	0.3	-0.7	-1.3	-0.8	0.5	-0.1	-0.4	-1.7
Medication: Ventolin 100micrograms inhaler	1.7	2.2	6.5	-2.5	-1.9	-0.4	-0.8	0.9	-0.7	-2.1	-1.6	1.2	-1.9	-0.2
Birth weight	0.1	0.3	1.2	-0.5	-0.2	0.4	-1.1	1.1	-0.2	-0.5	-0.5	0.0	-0.3	0.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.8	-0.8	0.6	0.3	1.1	0.2	-1.3	-0.7	0.1	-0.4	-0.4	-0.7
High blood pressure (siblings)	0.4	0.6	1.9	-0.2	-0.7	0.3	1.4	-0.3	-0.2	-0.7	-0.3	-1.4	-0.6	-1.1
Forced vital capacity (FVC), Best measure	1.7	6.4	15.7	4.0	2.0	2.4	0.9	0.8	0.3	3.7	3.2	1.6	3.5	2.0
Body fat percentage	4.1	16.2	33.6	-5.0	-3.8	-4.9	-3.4	0.3	-3.0	-5.8	-4.0	-0.8	-5.6	-3.6
Leg fat percentage (right)	4.4	15.8	29.1	-4.9	-3.1	-5.1	-3.8	0.4	-3.5	-5.4	-3.7	-1.8	-5.2	-3.8
Arm fat-free mass (right)	0.5	2.4	6.5	-0.8	-1.0	-1.8	-2.0	2.5	-2.3	-1.1	-0.4	-0.9	-1.0	-1.6
Exposure to tobacco smoke outside home	0.3	0.5	1.1	0.7	1.0	1.0	0.9	0.5	-0.6	0.6	0.5	0.3	0.4	-0.4
Comparative body size at age 10	0.6	1.6	4.3	-0.9	-2.1	-0.3	-1.3	1.9	-1.3	-1.3	0.1	0.0	-0.9	-1.8
Number of full brothers	0.3	0.3	1.3	-0.6	0.1	-0.5	-1.2	0.8	-0.2	-0.7	0.2	-0.1	-0.5	-0.4
Worry too long after embarrassment	0.3	0.4	1.1	-0.7	0.3	-1.0	-0.8	0.9	-0.9	-0.1	0.2	-0.2	-0.1	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	4.7	-1.5	-1.3	-1.6	-0.9	0.3	-2.2	-1.7	-1.4	-1.4	-1.4	-1.3
Wheeze or whistling in the chest in last year	2.4	4.3	10.1	-2.7	-1.7	-1.8	-3.2	0.1	-1.7	-2.5	-2.8	-0.6	-2.6	-0.3
Number of children fathered	3.3	3.7	11.3	-1.7	-1.3	-1.6	0.6	1.3	-2.1	-2.6	-1.6	0.6	-2.5	-3.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.0	0.3	0.8	0.1	0.1	0.4	-0.2	0.1	0.6	1.0	0.4	-0.1
Age at first live birth	0.9	1.6	8.6	-0.1	-2.9	0.7	0.0	-1.8	-0.5	-0.2	-0.4	1.0	-0.5	-1.7
Pulse wave peak to peak time	1.0	1.2	3.5	-0.8	-1.3	-0.5	1.9	-0.4	-1.3	-1.0	-1.0	-0.4	-0.8	-1.5
Health satisfaction	1.1	1.4	3.3	-1.2	-1.4	-0.9	-1.7	0.5	0.1	-1.4	-1.8	0.5	-1.7	-0.4
Shortness of breath walking on level ground	1.7	2.1	4.5	-1.5	-1.4	-0.5	-1.5	0.0	-0.3	-2.0	-1.6	-0.9	-1.9	-2.1
Qualifications: College or University degree	0.4	1.3	4.7	0.7	-1.6	2.2	1.2	0.5	0.9	1.2	0.1	1.4	0.7	0.7
Eye problems/disorders: None of the above	1.3	1.5	7.7	0.5	0.3	0.4	1.4	0.4	2.8	0.8	0.3	1.5	1.6	1.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	0.5	0.3	0.1	0.3	0.9	-0.3	0.9	1.2	-1.1	1.1	0.9
Emphysema/chronic bronchitis	0.7	0.8	4.4	-0.2	-1.0	0.6	0.5	-0.4	-1.1	0.5	0.7	-2.1	0.6	-0.2
Medication for pain relief, constipation, heartburn	0.4	0.7	1.6	0.5	-1.2	0.3	1.0	-1.3	1.3	0.3	0.8	0.5	0.6	0.3
Neck or shoulder pain in last month	0.4	0.5	1.4	-0.8	0.5	-0.7	-1.2	-0.6	-0.6	-0.6	-0.5	-0.8	-0.7	-0.4
Medication: Blood pressure	0.6	1.1	5.3	-0.9	-0.7	-0.3	0.8	1.0	-0.4	-1.2	0.4	-1.3	-0.8	-2.3
Angina (self-reported)	1.2	1.6	4.7	-0.9	0.1	-1.0	-1.3	-1.5	-1.0	-1.3	-1.4	-2.2	-1.3	-1.0
Migraine (self-reported)	0.6	0.8	3.2	0.3	0.8	-0.3	1.3	1.2	-1.8	0.5	0.7	-0.7	0.5	0.5
Medication: Ibuprofen	0.8	1.0	6.2	0.0	0.8	-0.9	-1.4	2.5	-0.8	-0.0	-0.3	-0.4	-0.1	0.3
Medication: Allopurinol	2.3	3.1	8.3	-1.8	-1.9	-2.5	-0.3	1.5	0.1	-2.0	-1.0	-2.9	-2.0	-1.1
Medication: Omeprazole	0.6	0.7	1.7	-0.9	-0.4	-0.6	0.1	-0.7	-1.0	-1.2	-0.5	-0.4	-1.3	-1.0
Medication: Seretide 50 evohaler	0.9	1.1	2.7	1.3	1.1	1.4	1.1	-0.5	-0.7	1.2	1.6	0.2	1.0	0.1
Mean time to correctly identify matches	0.7	1.4	4.1	-1.1	-1.5	-2.0	-1.6	1.1	-0.6	-1.1	-0.6	-0.2	-1.1	1.0
Heart disease (mother)	0.7	0.8	3.1	-0.7	-0.4	-0.6	0.7	-0.2	-1.2	-0.9	-0.3	-1.8	-0.6	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.9	0.4	-0.2	1.4	0.4	0.7	-1.1	-0.1	-0.2	-0.5	0.0	0.1
Whole body fat mass	3.8	15.7	30.4	-4.6	-3.7	-4.8	-3.7	1.2	-3.5	-5.5	-3.8	-1.0	-5.3	-3.8
Leg fat mass (right)	3.8	14.9	27.4	-4.7	-3.3	-4.7	-3.6	1.2	-3.7	-5.2	-3.3	-1.2	-5.0	-4.0
Arm predicted mass (right)	0.5	2.4	7.1	-0.7	-0.6	-1.6	-2.3	2.7	-2.4	-1.0	-0.3	-1.0	-0.9	-1.6
Pulse rate, automated reading	0.2	0.5	2.5	-0.0	-0.1	-0.5	-1.1	0.4	1.6	-0.1	0.5	0.2	0.1	1.2
Alcohol intake frequency.	1.5	3.5	9.1	-3.0	-1.5	-0.4	1.1	-0.3	-1.4	-3.0	-2.0	-0.2	-2.6	-2.0
Comparative height size at age 10	0.3	1.6	8.8	-0.6	-1.6	-1.2	-0.6	1.1	-0.5	-1.0	-0.5	0.5	-1.1	-3.0
Number of full sisters	0.6	0.7	4.1	-0.2	0.2	-0.1	1.1	2.0	-0.5	-0.3	0.5	-1.0	0.0	0.6
Suffer from ‘nerves’	0.6	0.9	2.4	-1.2	-1.1	-0.6	-0.8	-0.7	-1.6	-0.8	-1.2	0.5	-0.7	-1.0
Overall health rating	0.7	1.5	5.6	-0.9	-0.1	-0.2	-0.4	-1.2	0.2	-1.4	-0.8	2.4	-1.2	-2.0
Chest pain or discomfort	0.3	0.4	1.3	-0.2	0.0	0.3	-0.9	-0.5	-1.0	-0.4	-0.5	0.0	-0.4	-1.2
Had major operations	3.4	3.9	9.0	-2.6	-0.3	-1.7	-3.0	1.4	-2.5	-2.0	-2.3	-1.0	-2.1	-1.4
Age at last live birth	1.1	1.6	6.0	-0.9	-2.1	0.2	0.3	-1.6	-1.2	-0.8	-0.8	0.2	-0.8	-2.4
Family relationship satisfaction	0.4	0.5	2.1	-0.2	-0.7	-1.4	-1.5	-0.8	-0.1	-0.3	-0.5	-0.2	-0.4	0.3
Leg pain on walking	1.4	1.8	3.9	-1.0	-1.0	-0.3	-1.5	-0.8	-1.8	-1.3	-1.3	-0.9	-1.8	-2.0
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	6.1	0.8	1.7	0.9	2.5	0.3	0.7	0.4	1.3	-0.2	0.7	-1.0
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.6	-0.8	0.7	-0.3	0.4	-1.1	-0.4	0.1	0.9	1.6	0.2	-1.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	-1.1	-0.8	0.0	-1.0	-0.1	0.6	-0.4	-1.1	0.6	-0.4	-0.6
Medication: Aspirin	1.2	1.6	4.2	1.4	1.8	1.0	1.4	0.0	-0.4	1.5	2.1	-1.0	1.5	0.4
Supplements: Vitamin C	0.8	1.0	3.6	-1.6	-1.9	-0.5	-0.5	0.2	-0.3	-0.9	-0.9	-0.9	-0.7	-1.0
Knee pain experienced in last month	1.3	2.1	7.5	0.5	-0.1	0.2	-2.2	-1.8	-1.7	-0.9	-1.2	-0.3	-1.0	-2.7
Hypertension (Self-reported)	0.5	1.3	3.8	0.3	0.0	1.0	-0.0	1.3	-1.9	-0.4	0.4	-1.9	-0.2	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	5.3	-1.1	-0.4	-0.2	-1.1	-2.3	-1.0	-1.6	-1.6	1.0	-1.5	-2.0
Illnesses of father: Heart disease	1.8	2.4	9.9	-1.1	-1.6	-0.4	1.8	-0.4	-1.9	-1.7	-0.3	-0.5	-1.6	-3.1
Illnesses of siblings: Diabetes	0.3	0.4	1.8	-0.6	-0.1	-0.5	0.3	-0.6	-0.5	-0.9	-0.1	-0.5	-0.6	-1.4
Smoking status: Previous	0.5	0.7	3.3	0.9	-0.1	-0.4	-1.3	-1.8	-0.5	0.7	0.5	-0.4	0.7	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	5.0	1.8	0.9	0.6	0.4	-0.4	0.4	2.1	1.5	2.2	1.8	1.0
Whole body fat-free mass	0.4	2.2	9.5	-0.7	-0.6	-1.0	-1.8	3.1	-2.4	-0.9	-0.1	-0.2	-0.8	-1.6
Leg fat-free mass (right)	0.6	3.0	7.4	-1.5	-1.6	-1.2	-1.5	2.7	-2.5	-1.9	-0.7	0.3	-1.7	-1.9
Arm fat percentage (left)	4.1	16.2	33.9	-4.9	-3.4	-4.8	-3.5	0.4	-3.2	-5.8	-4.0	-0.8	-5.6	-3.9
Average weekly red wine intake	0.6	0.9	2.0	1.1	-0.0	1.4	-0.1	1.4	0.4	1.4	1.1	0.4	1.2	-0.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.4	0.8	-0.4	-0.0	-0.3	-0.6	1.2	0.8	0.8	0.3	1.1	0.8
Mood swings	0.5	1.0	3.7	-0.7	0.8	-1.4	-1.3	0.0	-1.3	-0.4	-0.3	-1.9	-0.5	0.3
Loneliness, isolation	0.7	1.0	2.4	-0.6	-0.3	-1.2	-0.8	-1.5	0.2	-1.2	-1.0	-0.3	-1.2	-1.5
Long-standing illness, disability or infirmity	1.5	2.3	5.2	-1.7	-0.4	-1.8	-1.4	-0.6	-0.5	-2.3	-1.6	-1.7	-2.2	-1.1
Ever had bowel cancer screening	2.4	2.8	4.9	-1.4	-2.2	-0.9	-1.9	-0.4	-2.1	-1.7	-2.1	-1.5	-2.0	-0.9
Diabetes diagnosed by doctor	0.4	0.7	1.9	0.8	0.6	0.8	1.4	0.5	-0.8	0.2	1.4	-0.5	0.2	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.7	-0.5	0.4	-0.7	0.4	0.3	0.3	-0.6	-0.2	0.8	-0.2	-0.3
Friendships satisfaction	0.4	0.5	1.3	0.2	-1.1	-0.8	-0.9	-0.1	-0.4	-0.5	-0.8	-0.8	-0.6	-0.1
Qualifications: nursing, teaching	0.5	0.8	3.4	0.4	-0.8	1.8	-0.1	-1.5	0.1	0.5	0.3	1.2	0.3	-0.5
Commuting to job workplace: Walk	1.1	1.1	4.2	0.9	0.3	0.4	-0.7	1.1	2.0	0.8	0.1	0.4	0.7	2.1
Eye problems/disorders: Cataract	1.0	1.2	4.4	-0.7	-0.4	-0.0	-1.3	-1.2	-2.1	-0.8	-0.9	-0.7	-1.5	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	7.0	1.1	0.2	0.2	0.9	0.5	-2.6	1.1	1.3	-1.2	1.3	0.2
Medication for cholesterol	0.7	1.1	2.6	1.5	0.0	0.0	1.0	0.3	1.6	1.4	1.5	-0.4	1.3	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	8.2	-1.4	0.3	-2.3	-1.0	2.4	-1.1	-1.9	-1.2	-2.9	-1.7	-0.4
Back pain experienced in last month	1.2	1.7	7.1	-0.0	1.2	-0.2	0.3	0.3	-2.7	-1.1	0.1	-2.2	-1.0	-1.7
Mineral and other dietary supplements	0.5	0.7	2.2	0.7	0.4	0.9	0.5	-0.2	1.5	0.7	0.2	1.5	0.8	0.5
Breast cancer (self-reported)	0.3	0.3	1.0	-0.8	-0.4	-0.9	-0.6	0.7	0.1	-0.0	-0.2	0.3	-0.3	1.0
Asthma (self-reported)	2.0	3.9	8.8	-2.5	-2.1	-1.0	-1.8	1.1	-1.1	-3.0	-2.9	0.2	-2.9	-0.7
Osteoporosis (self-reported)	0.2	0.2	1.0	0.3	0.6	1.0	0.3	-0.3	0.3	-0.0	-0.6	0.0	-0.2	-0.4
Osteoarthritis (self-reported)	1.9	2.5	5.4	-1.3	-1.1	-2.0	-2.3	-0.9	-1.5	-1.7	-1.2	-1.4	-1.8	-1.5
Medication: Aspirin	0.9	1.2	3.0	1.1	1.2	1.1	1.3	-0.1	-0.8	1.1	1.7	-1.2	1.0	0.1
Medication: Gliclazide	1.2	1.3	6.5	-0.1	0.1	0.0	1.9	-1.7	1.2	-0.3	0.5	0.3	-0.0	-2.5
Illnesses of father: None of the above (group 1)	1.9	2.4	5.5	1.8	2.2	0.0	-1.7	0.2	2.4	2.0	0.6	0.7	1.8	1.2
Smoking status: Current	1.1	1.7	5.6	-1.4	-0.2	-1.1	-2.4	-1.8	0.8	-1.0	-0.9	-0.2	-1.0	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	3.7	1.7	0.2	0.9	0.2	1.5	0.0	1.5	1.9	0.6	1.5	0.9
Whole body water mass	0.4	2.1	8.4	-0.7	-0.5	-1.2	-1.8	2.9	-2.4	-0.9	-0.1	-0.3	-0.8	-1.6
Leg predicted mass (right)	0.5	2.9	7.3	-1.5	-1.5	-1.2	-1.4	2.7	-2.4	-1.9	-0.7	0.3	-1.7	-1.9
Arm fat mass (left)	3.4	14.1	26.8	-4.2	-3.2	-4.6	-3.8	1.1	-3.4	-5.2	-3.5	-1.1	-4.9	-3.8
Number of self-reported non-cancer illnesses	0.8	1.4	4.5	-1.1	-0.3	0.1	-0.3	0.3	-2.1	-1.5	-0.9	-1.8	-1.4	-1.1
Average weekly champagne plus white wine intake	2.4	3.2	6.9	2.6	1.4	1.1	1.9	-0.6	1.5	2.3	2.0	0.6	2.6	1.7
Miserableness	0.4	0.6	3.0	0.1	0.6	-0.8	-1.4	0.4	-0.7	0.2	0.2	-1.7	0.1	-0.6
Guilty feelings	0.2	0.3	1.3	0.2	0.5	0.2	1.1	-0.4	0.0	-0.0	0.7	0.6	0.1	-1.0
Wears glasses or contact lenses	2.3	2.7	10.1	-0.9	-1.6	-1.6	-1.0	0.3	-3.2	-1.8	-0.8	-2.3	-1.8	-0.8
Ever taken oral contraceptive pill	0.6	0.6	3.2	0.8	0.2	0.3	1.2	-1.8	0.0	0.9	0.6	0.1	0.6	0.4
Hearing aid user	0.8	0.8	2.7	-0.8	0.9	-1.6	-1.4	0.6	-0.3	-0.8	-0.4	-1.0	-0.8	-0.7
Mother’s age at death	0.2	0.2	0.6	0.2	-0.1	-0.2	0.7	-0.8	-0.4	-0.3	-0.6	0.2	-0.4	0.3
Financial situation satisfaction	1.4	1.7	4.5	-1.5	-0.9	-0.7	-1.1	-1.1	1.5	-1.6	-2.1	0.2	-1.9	-0.2
Tinnitus: Yes, now most or all of the time	1.0	1.2	4.8	-0.4	-0.2	-0.2	-0.4	1.7	-2.2	-0.5	0.6	-2.0	-0.4	0.4
Commuting to job workplace: Public transport	0.5	0.5	1.9	0.0	-1.4	-0.5	-0.3	1.1	-0.7	-0.3	-0.7	-0.2	-0.6	1.1
Eye problems/disorders: Glaucoma	0.3	0.3	1.4	-0.2	0.6	-0.1	-0.7	-0.1	-0.4	-0.0	-0.1	-0.7	-0.5	-1.2
Medication: Blood pressure	0.3	0.5	1.8	-0.1	0.7	0.9	-1.1	0.8	-1.4	0.1	0.1	-0.8	0.3	0.4
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.0	-1.4	-2.0	-0.9	-0.7	0.7	-1.7	-1.5	-1.1	-1.2	-1.6	-1.9
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.3	-0.1	-0.5	0.3	0.1	1.1	-0.7	0.2	0.4	-1.1	0.0	0.5
High cholesterol (Self-reported)	0.4	0.8	1.7	-0.1	-0.9	0.1	-0.2	-0.3	1.3	-1.0	-1.0	1.3	-0.9	-1.2
Medication: Bendroflumethiazide	0.5	0.7	1.6	-0.9	-0.7	-0.2	-1.1	0.1	-0.6	-1.3	-1.0	-0.8	-1.1	-0.6
Medication: Paracetamol	0.6	0.9	5.4	-0.8	-0.2	-1.0	0.0	0.3	-2.3	-0.7	-0.6	-1.3	-0.6	0.0
Medication: Lisinopril	0.4	0.5	1.9	0.1	0.2	0.0	0.9	0.9	0.3	0.3	1.2	-1.4	0.5	-0.3
Medication: Atorvastatin	0.8	1.0	3.5	1.4	0.3	1.9	-0.3	0.0	-1.4	0.8	1.5	-0.2	1.0	-0.4
Illnesses of father: High blood pressure	1.2	1.5	6.5	-0.8	-1.8	-0.5	-0.3	1.1	-2.5	-0.9	-0.7	-0.1	-1.3	1.2
Alcohol drinker status: Never	0.6	0.7	3.7	-1.2	-0.1	0.2	1.9	0.0	0.5	-1.1	0.2	0.7	-0.7	-0.4
Ever smoked	0.8	1.4	7.7	0.0	-0.2	-1.0	-2.8	-1.7	-0.9	0.0	0.0	-1.6	0.2	-0.3
Basal metabolic rate	0.6	3.3	7.1	-1.4	-1.1	-1.8	-2.2	2.6	-2.7	-1.7	-0.7	-0.3	-1.6	-2.2
Leg fat percentage (left)	4.6	16.6	30.8	-5.0	-3.7	-5.2	-3.9	0.5	-3.6	-5.5	-3.8	-1.7	-5.3	-3.6
Arm fat-free mass (left)	0.6	3.2	8.5	-1.0	-0.8	-2.0	-2.4	2.9	-2.7	-1.4	-0.6	-1.1	-1.3	-1.6
Number of operations (self-reported)	4.8	7.2	14.7	-3.8	-0.4	-2.6	-2.6	-0.7	-2.6	-3.1	-2.4	-2.4	-3.0	-3.6
Average weekly beer plus cider intake	0.5	0.8	3.5	1.2	0.4	0.3	0.8	-0.5	-0.5	0.5	1.0	0.6	0.8	-1.9
Irritability	1.2	2.1	13.8	-0.1	-0.6	-0.5	-0.1	-3.7	-1.8	0.4	0.8	-0.2	0.1	-2.2
Risk taking	0.1	0.1	0.4	0.6	-0.6	-0.5	0.1	0.0	0.3	0.1	0.1	0.4	-0.2	-0.3
Ever had prostate specific antigen (PSA) test	0.6	0.7	4.4	0.5	-0.0	-0.1	-0.2	-0.1	0.4	0.2	-0.3	2.1	0.0	-1.5
Fractured/broken bones in last 5 years	0.7	0.9	4.5	0.9	0.3	0.2	-0.2	2.1	0.3	0.8	1.2	-0.5	0.9	1.2
Age started oral contraceptive pill	0.5	0.6	2.3	-0.6	-0.6	-0.6	-0.7	-0.8	-0.1	-0.8	-1.5	-0.7	-1.0	0.4
Diastolic blood pressure, automated reading	0.6	1.8	6.5	-0.3	-1.8	-1.4	-2.0	1.1	-2.5	-1.1	-0.4	-0.6	-1.1	-0.4
Ever depressed for a whole week	0.7	0.9	3.1	1.0	0.6	1.3	-0.1	0.5	0.5	0.9	1.1	-0.6	1.0	1.7
Unable to work because of sickness or disability	1.5	1.9	5.4	-2.2	-0.5	-1.2	-0.7	-0.1	0.3	-2.1	-2.3	0.3	-2.0	-0.6
Commuting to job workplace: Cycle	0.8	1.0	5.3	-0.2	-1.1	0.0	-0.7	2.3	0.9	0.2	-0.5	0.4	0.1	1.5
Myopia	1.4	2.0	4.6	-1.8	-2.1	-0.2	-1.9	-0.7	0.2	-1.6	-1.6	1.4	-1.4	-0.8
Vascular/heart problems diagnosed by doctor	0.6	1.5	5.5	0.3	0.5	-0.4	0.2	-1.0	2.4	1.1	0.1	2.1	0.9	1.8
Cholesterol lowering medication	0.5	0.7	3.1	-0.6	0.4	-0.1	-1.0	0.1	-1.4	-0.6	-0.9	-0.1	-0.6	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.9	-1.1	-1.6	-0.4	0.1	-0.3	-1.1	-1.7	-0.9	-0.9	-2.0	-1.1
Pain experienced in last month	1.2	2.0	4.8	0.6	-0.2	0.7	1.2	1.6	2.2	1.3	1.0	1.7	1.3	2.1
Supplements: Calcium	1.2	1.3	3.1	-1.6	-1.3	-0.5	-0.8	-0.7	-0.5	-1.4	-1.8	-0.3	-1.5	-0.9
Basal cell carcinoma (self-reported)	1.6	1.9	5.4	1.1	1.8	0.9	1.1	-2.3	1.0	1.4	0.6	1.9	1.4	-0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	-0.4	-0.2	0.2	0.6	-0.2	0.5	-0.2	0.4	0.3	-0.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	3.2	-1.2	1.3	-1.8	-1.3	0.1	-0.9	-1.4	-0.9	-0.6	-1.3	-1.5
Heart disease (siblings)	1.3	1.6	7.6	0.6	2.8	1.1	2.1	-0.1	0.7	0.6	1.1	-1.1	0.5	-0.0
Alcohol drinker status: Previous	0.6	0.7	1.9	-1.0	-0.8	-0.8	1.4	-1.0	0.5	-1.0	-0.5	-0.2	-0.7	-0.4
Pack years of smoking	0.5	0.7	1.9	-1.3	-0.2	-1.0	0.0	0.5	-0.2	-1.4	-0.2	-0.8	-1.1	-0.6
Impedance of whole body	0.8	3.9	11.2	1.1	-0.5	1.7	2.6	-3.4	3.0	1.4	0.8	2.3	1.3	1.5
Leg fat mass (left)	3.9	15.3	28.7	-4.8	-3.6	-4.7	-3.5	1.0	-3.6	-5.4	-3.4	-1.2	-5.1	-4.0
Arm predicted mass (left)	0.6	2.8	7.1	-1.0	-0.7	-1.8	-2.3	2.6	-2.7	-1.3	-0.6	-1.1	-1.1	-1.6