Hub : Genes

GRID1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.2620 0.0990 6.6e-03 0.124 NA 0.086 NA 0.120 2.5e-07 NA 1.7e-05 NA 4.1e-07
2 GTEx Artery Coronary 0.5130 0.1000 1.1e-04 0.017 NA 0.001 NA 0.043 8.7e-02 NA 3.0e-01 NA 1.4e-02
3 GTEx Artery Tibial 0.1641 0.0507 2.2e-04 0.075 NA 0.058 NA 0.056 1.7e-06 NA 2.6e-05 NA 3.2e-05
4 GTEx Nerve Tibial 0.1406 0.0504 3.1e-03 -0.003 NA 0.004 NA -0.002 5.9e-01 NA 1.7e-01 NA 5.3e-01
5 GTEx Stomach 0.2230 0.0840 9.7e-03 0.015 NA 0.016 NA 0.038 5.9e-02 NA 5.3e-02 NA 6.4e-03
6 ROSMAP Brain Pre-frontal Cortex 0.1331 0.0324 1.2e-07 0.070 0.070 0.088 0.077 0.067 2.2e-09 2.5e-09 2.3e-11 4.2e-10 4.8e-09
7 TCGA Breast Invasive Carcinoma 0.0940 0.0251 4.7e-07 0.045 0.033 0.029 NA 0.033 1.6e-09 2.2e-07 1.1e-06 NA 2.1e-07
8 TCGA Colon Adenocarcinoma 0.1940 0.0780 9.8e-03 0.047 0.026 0.072 NA 0.077 9.9e-04 1.1e-02 5.8e-05 NA 3.1e-05
9 TCGA Lung Adenocarcinoma 0.0520 0.0221 5.6e-03 0.016 0.013 0.015 NA 0.016 4.8e-03 1.0e-02 6.8e-03 NA 4.5e-03
10 TCGA Lung Squamous Cell Carcinoma 0.0748 0.0322 6.0e-03 0.034 0.013 0.012 NA 0.023 8.7e-05 1.0e-02 1.3e-02 NA 9.7e-04
11 TCGA Prostate Adenocarcinoma 0.1426 0.0525 1.3e-03 0.004 0.020 0.010 NA 0.009 1.2e-01 2.8e-03 2.8e-02 NA 3.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.5 0.7 2.4 0.7 0.6 1.5 0.6 -1.6 -0.0 0.5 0.5 -1.0 0.7 -0.3
Bipolar Disorder or Schizophrenia 0.3 0.8 3.6 -0.6 -1.1 0.3 -0.1 -1.9 1.1 -0.5 -1.2 -0.5 -0.2 0.1
Depressed Affect (Nagel 2018) 1.4 3.0 6.2 -1.4 -1.0 -2.5 -1.7 0.2 -1.7 -1.7 -1.2 -2.5 -1.7 -1.9
Depression (Nagel 2018) 0.2 0.3 1.2 0.6 -0.5 -0.0 0.2 -1.1 -0.7 -0.1 0.1 -1.0 -0.2 -0.4
Intelligence (Savage-Jansen 2018) 0.7 2.3 6.5 -1.3 -2.0 -1.5 -2.5 -1.2 0.5 -1.5 -1.9 -0.3 -1.8 -0.7
Neuroticism (Nagel 2018) 0.5 1.1 2.7 -0.8 -1.3 -1.6 -0.8 -1.2 -1.0 -0.6 -0.5 -1.1 -0.7 -1.2
Schizophrenia (2018) 0.7 1.4 4.1 -1.1 -1.9 -0.8 -0.6 -1.4 1.5 -1.0 -2.0 0.2 -0.8 0.3
Schizophrenia vs Biploar Disorder 0.3 0.4 2.5 -0.3 -0.3 0.5 -0.4 1.6 0.5 0.4 -0.0 0.5 0.1 0.6
Worry (Nagel 2018) 0.3 0.6 3.0 -0.2 -1.3 0.1 0.5 -1.7 -1.1 0.6 0.1 -0.0 0.5 0.1
Alzheimer’s Disease (in mother) 1.1 1.2 3.5 0.9 1.9 0.6 -0.3 1.0 -1.3 0.7 0.7 -1.3 1.0 1.5
Alzheimer’s Disease (in father) 1.6 1.7 6.7 0.7 0.3 1.6 2.6 -1.3 -0.8 0.8 0.9 -0.9 1.0 -1.8
Alzheimer’s Disease (including proxy) 0.9 1.3 3.5 1.2 1.6 1.3 0.7 0.1 -1.3 1.0 0.9 -1.9 1.2 -0.1
Crohns Disease (2017) 0.3 0.6 2.1 -0.7 -1.4 1.3 -0.1 0.2 -0.4 -0.1 -0.1 1.1 0.2 0.7
Irritable Bowel Disease (IBD) 0.5 1.2 4.2 -2.1 -2.0 0.1 -0.0 -1.4 0.2 -1.0 -0.9 0.9 -0.9 -0.2
Ulcerative Colitis (UC) 1.5 2.8 6.6 -2.6 -2.1 -1.3 -0.3 -2.5 0.8 -1.8 -1.8 0.6 -1.7 -1.3
Major Depression (MDD) 0.6 0.7 2.7 -0.5 -1.7 -1.1 -0.4 -0.3 0.7 -0.6 -0.8 -0.8 -0.2 -1.1
Reaction Time 0.3 0.6 2.4 -0.3 -0.7 -1.5 -0.6 0.4 0.8 -0.4 -0.1 0.5 -0.5 1.5
Verbal and Numeric Reasoning (VNR) 1.6 3.7 8.1 -1.8 -1.5 -2.2 -2.8 -2.3 -0.7 -2.1 -2.4 -1.1 -2.3 -0.8
Breast Cancer 1.0 2.4 5.3 2.3 1.8 -0.5 -0.2 1.2 -1.1 1.9 1.8 -1.1 1.7 2.1
Ovarian Cancer 2.3 3.1 7.5 -2.7 -0.9 -2.0 -0.8 0.4 -2.0 -2.5 -1.9 -0.9 -2.4 -0.7
Prostate Cancer 1.0 1.4 2.9 1.4 1.4 0.8 -0.6 1.0 1.7 1.2 1.2 0.2 1.1 1.5
Age at First Birth 0.8 1.1 5.9 0.2 -1.2 0.2 0.0 -2.4 0.9 1.1 0.2 0.7 1.0 -1.2
Bipolar Disorder (2011) 0.6 0.6 1.7 0.1 -0.6 -1.0 0.8 -1.3 0.7 -0.3 -0.3 -1.2 -0.3 -0.7
Body Mass Index (BMI) (2010) 1.7 2.3 5.5 -2.3 -0.4 -0.5 -1.7 2.0 -1.2 -2.0 -1.3 -0.2 -1.8 -1.4
Coronary Artery Disease (CAD) 0.8 1.0 3.2 -1.8 -0.9 -0.6 0.1 -1.2 -1.0 -1.4 -0.9 0.3 -1.1 -0.2
Crohns Disease (2012) 1.0 1.5 5.6 0.2 -1.3 2.4 2.1 0.7 -0.5 0.7 0.9 0.5 1.0 1.4
Mean Putamen Volume 0.3 0.4 1.8 -0.5 0.1 0.2 -0.3 1.3 -1.2 -0.2 -0.4 -0.2 -0.3 -0.5
Fasting Glucose 0.4 0.4 1.9 0.1 0.6 0.7 0.8 0.2 -1.4 -0.5 -0.5 0.2 -0.7 0.4
HbA1C 0.5 0.6 2.9 -0.3 0.4 0.6 0.6 0.9 0.8 0.2 0.6 1.7 0.5 -0.6
HDL Cholesterol 0.3 0.5 1.5 -0.2 -1.1 -0.3 -1.1 -0.4 0.5 -0.1 -0.7 1.2 -0.0 0.1
LDL Cholesterol 0.7 1.0 3.4 -0.5 0.9 -1.1 -1.8 -0.8 0.4 -0.8 -0.5 -1.2 -1.0 -1.3
Lupus 0.7 1.0 2.6 0.6 -0.1 0.6 0.0 0.6 0.8 1.2 1.5 1.3 1.4 1.6
Neuroticism (2016) 0.4 0.5 1.7 -0.0 -0.9 -1.3 -0.4 -0.5 -1.0 -0.5 -0.5 -1.1 -0.4 -0.5
Primary Biliary Cirrhosis 0.6 0.9 2.3 0.2 0.9 1.5 0.8 -0.9 0.1 0.9 1.0 1.0 0.6 1.4
Rheumatoid Arthritis 0.6 0.8 1.7 -0.8 -0.3 -1.2 -1.3 -0.1 -0.0 -1.3 -1.0 -0.1 -1.1 1.1
Schizophrenia (2014) 0.6 1.2 3.2 -1.3 -1.6 -0.2 -0.9 -1.7 0.8 -0.9 -1.8 -0.5 -0.6 -0.3
Triglycerides 1.2 1.9 7.3 -1.6 -0.0 -1.6 -0.3 0.2 -2.2 -1.2 -0.2 -2.7 -1.4 -0.2
Type 2 Diabetes (T2D) (2012) 0.3 0.4 1.4 0.1 0.7 0.4 0.9 -1.2 -0.4 -0.2 0.6 0.6 -0.4 0.4
Ulcerative Colitis 1.3 1.8 5.7 -2.4 -1.6 -0.1 0.1 -2.0 0.5 -1.1 -1.0 1.5 -1.2 -1.2
Blood Eosinophil Count 0.2 1.6 3.1 1.7 1.0 1.2 0.4 0.8 0.4 1.7 1.2 0.5 1.7 1.8
Blood Platelet Count 0.1 1.3 4.5 -1.0 -1.0 -2.1 -0.9 -0.2 -1.1 -1.4 -0.5 -1.4 -0.9 0.5
Blood Red Count 0.1 0.8 5.3 -0.3 0.7 0.1 -2.3 0.0 -0.6 -0.2 -0.8 1.3 -0.2 -0.7
Blood White Count 0.1 1.0 4.5 -0.1 0.7 -0.0 0.4 -1.5 -2.1 -0.1 1.1 -1.1 0.5 -0.7
Heel T-Score 0.3 2.3 5.4 -2.1 -0.4 -0.1 -0.8 -2.0 -2.0 -1.8 -0.9 -0.4 -1.5 -2.3
BMI 2.9 16.9 32.6 -4.9 -3.4 -4.6 -4.7 3.5 -3.0 -5.7 -3.9 -1.0 -5.2 -3.3
Height 0.1 2.5 8.4 1.8 -0.4 1.1 2.0 2.0 -0.8 1.5 1.4 2.9 1.3 -0.0
Waist Hip Ratio (WHR) 0.1 0.4 1.6 -0.7 -1.2 0.3 0.4 0.9 -0.7 -0.8 -0.0 -0.6 -0.4 -0.3
Systolic Blood Pressure 0.1 0.6 2.6 0.9 0.3 0.7 -1.2 0.4 -0.6 0.3 0.4 -1.6 0.5 0.8
Smoking Status 1.3 3.0 11.8 -1.1 -0.7 -1.3 -3.4 -3.2 0.8 -0.6 -0.5 -0.7 -0.5 -2.3
Allergy or Eczema 0.1 0.4 1.5 0.8 -0.7 1.2 0.0 0.4 -0.5 0.3 0.4 0.8 0.1 0.1
Cardiovascular Disease 0.1 0.4 1.5 0.1 0.1 1.1 0.1 1.2 -0.8 -0.1 0.6 -0.4 0.2 -0.7
Hypothyroidism (self reported) 0.3 0.7 2.2 -0.3 1.0 -0.3 -0.3 1.4 -0.8 -0.2 -0.0 -1.5 -0.3 -1.4
Respiratory disease 0.8 1.7 3.2 -1.1 -1.7 -0.9 -0.4 1.8 -1.7 -1.6 -1.2 -1.2 -1.4 0.2
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.0 -0.8 0.2 0.1 0.3 0.4 -0.0 -1.0 -0.1 -0.7 -0.6 -1.0
Lung FEV1/FVC ratio 0.2 0.9 4.0 0.8 -0.7 0.4 1.0 -0.5 -1.2 0.3 1.1 0.5 0.4 -2.0
Lung FVC 1.1 5.7 15.3 3.9 1.8 1.6 0.1 0.4 1.0 3.6 2.8 0.4 3.6 2.6
Neuroticism 0.3 0.7 2.6 -0.1 -0.4 -1.6 -0.9 -0.3 -1.6 -0.1 -0.1 -1.0 -0.2 -0.0
Chronotype (morning person) 2.3 5.3 12.8 -2.9 -2.7 0.8 1.6 -0.7 -3.0 -2.5 -1.8 0.4 -2.8 -3.6
Hair Pigment 0.0 0.4 3.0 -0.3 -0.4 -0.5 -0.8 -1.7 -0.4 -0.0 -0.4 -0.4 0.0 -0.3
Tanning 0.1 0.9 4.6 -0.3 -2.1 -0.9 -1.0 -0.2 -1.1 -0.4 0.0 -0.9 -0.6 -1.2
Hand grip strength (left) 1.1 3.0 6.3 2.4 0.5 2.2 0.4 1.9 -0.6 2.5 2.1 -0.4 2.4 1.0
Number of treatments/medications taken 0.8 1.4 5.5 -1.2 1.0 -1.0 -0.0 -0.2 -2.4 -1.1 -0.1 -1.7 -1.0 -0.9
Average weekly spirits intake 1.7 2.1 6.5 -1.0 0.3 -1.7 -1.3 -0.3 -2.6 -1.3 -0.6 -2.3 -1.2 -1.3
Sensitivity / hurt feelings 0.3 0.5 2.8 0.0 1.7 -0.7 0.5 -0.2 -0.2 0.3 0.7 0.7 0.4 0.4
Frequency of depressed mood in last 2 weeks 0.4 0.6 2.9 0.3 1.3 -0.0 -0.3 -1.1 -0.7 0.3 0.2 -1.7 0.1 -0.3
Hearing difficulty/problems: Yes 1.3 2.0 6.5 -1.2 -1.3 -2.5 -1.6 0.4 0.1 -1.5 -0.7 -0.2 -1.6 -2.1
Relative age of first facial hair 0.5 1.1 4.2 2.1 0.8 0.0 0.5 -0.1 1.3 1.2 0.8 -0.6 1.1 1.4
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 7.7 0.3 1.1 0.6 -0.5 -2.3 1.9 0.9 -0.1 2.8 0.5 -0.4
Ever used hormone-replacement therapy (HRT) 2.3 3.0 4.8 -2.1 0.6 -1.6 -0.8 -1.9 -2.2 -1.7 -1.4 -1.6 -1.9 -2.1
Ever had hysterectomy (womb removed) 1.2 1.3 3.1 -1.1 -1.1 -1.8 -1.7 0.7 -0.3 -1.3 -1.2 -1.1 -1.1 -0.6
Systolic blood pressure, automated reading 1.3 3.9 10.3 -1.5 -1.8 -2.0 -3.2 1.3 -2.0 -2.1 -1.9 -2.0 -2.0 -1.0
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.8 0.4 0.8 -0.6 0.5 0.9 -0.1 0.2 0.8 0.1 -0.1 0.9
Angina 0.8 1.1 2.6 -0.4 0.4 -0.7 -0.8 -1.6 -1.1 -0.9 -1.0 -1.6 -1.0 -1.3
Medication for hormone replacement therapy 1.3 1.5 3.9 -2.0 -0.4 -1.5 -0.4 0.5 -0.5 -1.6 -1.8 0.7 -1.6 0.5
Vitamin and mineral supplements 0.7 0.9 3.3 0.7 1.5 0.6 0.1 0.1 1.1 1.0 0.4 0.7 0.8 1.8
Supplements: Zinc 0.3 0.3 1.5 -0.5 -0.3 0.1 -0.1 -0.1 1.2 -0.4 -0.3 0.3 -0.4 -1.1
Medication: Co-codamol 0.6 0.7 4.7 -0.3 -0.2 0.4 0.8 -1.0 -0.5 -0.2 0.6 -2.2 0.2 -0.8
Medication: Metformin 0.6 0.9 5.5 0.2 2.3 0.8 0.7 -0.3 0.9 0.6 1.1 -0.1 0.5 -0.0
Diabetes (father) 0.2 0.3 1.6 -0.2 -0.6 0.4 0.3 1.3 -0.7 -0.1 -0.1 0.4 0.0 0.7
Diabetes (mother) 1.1 1.3 4.2 1.6 1.0 0.8 1.1 -0.6 -0.3 1.1 1.7 2.0 0.9 0.2
Severe depression (siblings) 0.6 0.7 1.7 -0.6 -1.3 0.4 0.2 -0.9 -0.7 -1.1 -0.5 -1.1 -1.2 -0.2
Pack years adult smoking proportion 0.5 0.7 2.1 -1.3 -0.3 -1.0 -0.2 0.5 -0.5 -1.4 -0.4 -0.8 -1.2 -0.5
Impedance of leg (right) 0.7 3.2 9.3 1.5 0.5 1.2 1.8 -3.1 2.6 2.0 1.0 0.9 1.8 1.5
Leg fat-free mass (left) 0.6 3.4 7.9 -1.6 -1.2 -1.5 -1.8 2.8 -2.6 -2.0 -0.7 0.0 -1.8 -2.2
Trunk fat percentage 3.6 14.2 30.5 -4.6 -3.9 -4.5 -3.0 0.1 -2.7 -5.5 -3.8 -0.5 -5.3 -3.4
Hand grip strength (right) 2.4 6.5 15.0 3.4 2.4 2.7 1.4 1.6 -0.8 3.7 3.3 0.3 3.9 1.3
Townsend deprivation index at recruitment 0.9 1.3 6.5 -0.9 1.1 0.1 -0.6 -1.7 2.5 -0.5 -0.5 1.1 -0.3 -0.8
Current tobacco smoking 1.0 1.7 5.2 -1.4 -0.4 -0.9 -2.3 -1.9 1.0 -1.1 -0.9 -0.3 -1.0 -1.6
Average weekly fortified wine intake 0.9 1.0 5.1 -1.0 0.4 0.4 -0.9 -0.2 -2.3 -0.4 -0.5 -1.7 -0.6 -0.1
Maternal smoking around birth 0.3 0.4 1.3 -0.2 -1.0 -1.1 0.4 -0.4 -0.3 -0.5 0.2 -1.1 -0.1 -0.7
Fed-up feelings 0.7 1.2 4.1 -0.8 0.3 -1.1 -1.2 -0.4 -0.9 -1.1 -0.5 -1.4 -1.1 -2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.6 -0.1 -0.1 -0.2 -0.3 -0.8 0.1 -0.5 -0.3 -0.6 -0.5 -0.1
Relative age voice broke 1.4 2.1 7.0 2.6 0.7 1.1 2.0 -0.4 0.4 1.6 2.0 0.2 1.7 0.6
Taking other prescription medications 1.8 2.7 6.7 -2.0 -0.0 -1.5 -1.1 0.0 -1.2 -2.2 -1.5 -2.6 -2.4 -1.1
Age when periods started (menarche) 1.8 4.4 9.2 3.0 1.1 2.5 1.5 -1.2 1.5 2.9 1.8 0.4 2.8 2.5
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 3.4 -0.2 0.5 -1.9 -1.2 -0.1 -0.8 -0.9 -0.4 -1.8 -0.9 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 5.6 -0.5 0.3 -1.4 0.3 -2.4 -1.9 -1.3 -0.7 -1.9 -1.2 -1.9
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 2.2 -0.0 0.9 -0.3 -0.6 -0.9 1.5 0.2 -0.3 -0.7 0.0 0.4
Qualifications: CSEs or equivalent 1.0 1.3 8.5 -0.2 -0.2 0.4 -0.2 0.1 1.5 -0.2 -0.3 1.7 0.1 2.9
Serious illness, injury or assault to yourself 1.3 1.6 4.7 -2.2 -0.5 -1.5 -1.5 -0.2 -0.4 -1.6 -1.1 0.7 -1.9 -0.7
High blood pressure 0.5 1.3 4.2 -0.1 -0.4 0.6 -0.2 1.1 -2.1 -0.8 0.1 -1.9 -0.6 -1.9
Hayfever, allergic rhinitis or eczema 0.3 0.7 3.7 0.6 -1.1 1.6 0.2 0.3 0.4 0.2 0.2 1.9 -0.2 -0.2
Multivitamins +/- minerals 0.3 0.4 2.9 -0.1 -0.4 0.3 0.1 0.3 -0.8 -0.5 0.1 -0.3 -0.5 -1.7
Stomach or abdominal pain in last month 1.0 1.2 2.9 -1.3 -0.6 -0.3 -0.0 0.5 -1.6 -1.7 -1.2 -1.2 -1.5 -0.4
Supplements: Glucosamine 2.2 2.9 4.9 -1.9 -1.1 -2.0 -2.2 -1.1 -1.6 -2.0 -1.6 -0.8 -2.0 -1.8
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 3.1 -0.6 -0.2 -0.4 -1.0 -0.7 -1.8 -0.5 -0.3 -0.4 -0.7 -0.8
Medication: Atenolol 0.8 1.0 4.7 -0.1 -1.9 0.9 0.6 -0.6 -1.1 0.0 0.2 -2.2 0.2 -0.4
Medication: Levothyroxine sodium 0.2 0.3 1.8 -0.2 -0.0 0.6 0.3 1.3 -0.5 -0.5 -0.5 -0.4 -0.3 -0.6
Sitting height 0.5 3.2 8.2 2.9 1.9 1.5 0.1 0.8 1.7 2.6 1.7 1.8 2.2 0.8
Chronic bronchitis/emphysema (father) 0.2 0.3 1.1 -0.5 -0.2 -0.2 -0.1 0.7 0.2 -0.8 -0.3 -0.6 -0.5 -1.0
High blood pressure (mother) 0.7 1.0 4.4 -0.3 -1.0 -0.3 -2.1 0.1 -1.5 -0.6 -0.6 0.8 -0.8 -0.9
Body mass index (BMI) 3.3 14.1 26.1 -4.3 -2.4 -4.7 -3.9 1.6 -3.8 -5.1 -3.4 -1.8 -4.8 -3.5
Impedance of leg (left) 0.6 2.8 10.6 1.1 -0.6 1.1 1.9 -3.3 2.4 1.5 0.7 1.1 1.4 1.7
Leg predicted mass (left) 0.6 3.2 7.2 -1.6 -1.2 -1.5 -1.8 2.7 -2.4 -1.9 -0.7 0.1 -1.8 -2.2
Trunk fat mass 3.2 13.7 27.5 -4.3 -3.6 -4.5 -3.3 0.9 -3.2 -5.2 -3.5 -0.6 -5.0 -3.6
Waist circumference 3.2 11.9 20.9 -3.9 -3.4 -4.0 -3.5 2.0 -3.7 -4.6 -2.9 -1.2 -4.2 -3.0
Number of incorrect matches in round 0.8 1.4 4.6 -1.1 -0.9 -2.1 -1.0 1.3 -1.8 -1.0 -0.6 -0.5 -1.1 0.2
Past tobacco smoking 0.7 1.3 5.5 -0.4 0.2 0.9 2.3 2.3 0.7 -0.6 -0.4 0.7 -0.7 0.5
Alcohol usually taken with meals 0.6 1.0 6.0 0.1 -0.5 0.5 -0.7 1.6 0.5 0.5 -0.0 0.9 0.3 2.4
Nervous feelings 0.4 0.7 4.4 -0.8 -2.1 0.0 -0.4 -0.7 0.1 -0.4 -1.0 -0.3 -0.5 0.1
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 3.3 1.7 0.7 1.7 1.1 -0.6 0.5 1.7 1.4 -0.2 1.8 1.3
Hearing difficulty/problems with background noise 0.6 1.0 2.5 -1.0 0.2 -0.7 -0.9 -0.0 0.0 -1.2 -1.1 0.9 -1.6 -1.5
Hair/balding pattern: Pattern 2 0.4 0.5 1.4 0.9 0.8 0.1 0.5 -0.3 1.2 0.8 0.5 -0.3 0.7 0.5
Had menopause 1.3 1.6 5.6 -1.5 -0.5 -1.6 -2.4 0.3 -0.0 -1.4 -1.3 -0.5 -1.4 1.1
Had other major operations 1.1 1.3 4.4 -2.1 -1.6 -0.4 -0.2 1.5 -0.1 -1.3 -0.3 -0.9 -0.9 -1.3
Forced vital capacity (FVC) 1.7 6.4 15.6 4.0 1.8 2.8 1.7 0.3 -0.0 3.7 2.9 1.9 3.5 1.7
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 3.1 -0.5 0.0 -1.4 -0.4 -0.8 -1.5 -1.3 -0.8 -1.8 -1.3 -1.4
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 1.7 -0.5 -0.8 0.4 0.2 -0.0 -0.1 -0.3 0.4 -1.3 0.1 0.7
Qualifications: None of the above 1.8 3.8 8.6 -2.9 -0.9 -2.6 -1.3 0.5 -2.1 -2.5 -1.6 -2.0 -2.1 -1.3
Financial difficulties in last 2 years 1.0 1.3 3.3 1.2 0.0 1.8 0.6 -1.6 1.0 0.8 1.7 -0.4 0.9 -1.1
Mouth/teeth dental problems 2.4 3.7 9.9 -2.7 -1.4 -1.2 -1.0 -1.2 0.6 -2.9 -2.6 0.8 -3.1 -1.3
Heart attack 0.1 0.2 0.6 -0.4 -0.3 0.3 0.8 -0.5 0.3 -0.3 0.4 0.4 -0.2 -0.4
Allergy 0.7 1.6 3.6 1.2 1.8 0.2 0.7 -0.2 1.1 1.7 1.5 -0.9 1.9 1.1
Pain all over the body in last month 0.4 0.4 1.9 0.5 0.0 0.5 -0.3 -1.4 -0.7 0.7 0.5 0.2 0.8 -0.3
Diabetes (self-reported) 0.6 0.9 3.4 0.2 0.5 1.0 1.8 -0.3 -1.5 -0.1 1.3 -0.7 0.1 -0.6
Hayfever/allergic rhinitis (self-reported) 2.1 2.8 5.9 2.2 2.0 1.9 0.3 -0.6 1.8 2.1 1.0 2.4 1.7 0.2
Medication: Ramipril 0.8 1.0 3.1 -1.0 0.3 -1.0 -0.4 -0.3 -1.8 -1.3 -1.0 -0.3 -1.3 -1.0
Medication: Simvastatin 1.6 2.4 5.7 -2.4 -0.8 -1.4 0.5 -0.4 -1.1 -2.3 -1.4 0.0 -2.0 -2.4
Fluid intelligence score 0.6 1.3 4.1 -0.7 -0.0 -1.5 -2.0 -1.5 0.6 -0.8 -1.3 -0.6 -1.3 -0.2
Illnesses of siblings 0.9 1.2 7.5 -0.8 -0.3 -1.8 -2.7 0.1 -0.5 -0.2 -0.9 0.7 -0.4 0.5
Neuroticism score 0.3 0.7 3.5 -0.9 0.1 -0.8 -0.9 -0.9 -1.9 -0.6 -0.3 -0.4 -0.6 -0.6
Weight 1.8 8.8 14.7 -3.0 -2.2 -3.7 -3.2 1.9 -3.4 -3.8 -2.3 -0.6 -3.6 -3.2
Impedance of arm (right) 0.6 2.8 9.3 0.4 -0.6 1.6 2.4 -3.0 2.2 0.6 0.5 2.5 0.5 0.7
Arm fat percentage (right) 3.9 15.4 32.8 -4.9 -3.3 -4.6 -3.3 0.5 -3.3 -5.7 -3.9 -0.6 -5.4 -3.8
Trunk fat-free mass 0.3 1.7 8.4 0.0 -0.0 -0.8 -1.7 2.9 -2.2 -0.1 0.4 -0.3 -0.1 -1.2
Hip circumference 2.2 9.5 15.8 -3.1 -3.1 -3.9 -3.0 1.3 -3.4 -4.0 -2.5 -0.6 -3.8 -3.3
Time employed in main current job 0.4 0.5 2.6 0.2 -0.3 -0.2 0.1 -1.1 1.6 0.0 -0.4 0.4 -0.2 -1.0
Alcohol intake versus 10 years previously 0.9 1.3 3.0 -1.4 -1.7 -0.5 -1.5 0.5 -1.4 -1.0 -1.5 1.0 -0.8 -0.6
Father’s age at death 0.9 1.2 4.2 -0.8 -1.4 -0.8 -0.3 0.9 -2.1 -0.5 -0.8 -0.9 -0.5 1.6
Worrier / anxious feelings 0.4 0.7 2.2 0.9 0.2 1.5 0.1 0.3 1.1 1.0 0.5 1.0 1.0 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 3.2 0.1 0.8 -0.8 -0.3 -0.8 0.5 -0.4 -0.6 1.8 -0.4 -0.5
Falls in the last year 0.9 1.2 2.7 -0.9 0.3 -1.2 -1.0 1.2 -1.3 -1.6 -0.4 -1.3 -1.5 0.1
Hair/balding pattern: Pattern 3 0.3 0.5 1.4 -0.9 -0.2 -0.2 -0.5 -0.1 -1.2 -0.9 -0.3 -0.5 -0.7 -0.9
Number of live births 0.6 0.8 3.0 0.6 1.7 0.2 1.3 0.1 -0.4 0.6 0.3 -1.7 0.7 0.1
Forced expiratory volume in 1-second (FEV1) 1.9 6.5 15.4 3.9 1.5 3.0 2.1 0.5 -0.2 3.7 3.0 2.1 3.5 1.1
Pulse rate 0.6 0.9 4.0 -0.9 -0.8 0.2 -1.6 0.6 2.0 0.1 0.1 1.0 0.3 1.1
Happiness 0.7 0.8 2.2 -0.7 -1.5 -0.7 -1.4 0.1 -0.4 -0.8 -0.8 -0.8 -1.0 0.8
Noisy workplace 0.9 1.1 3.8 -1.1 -0.8 -0.7 0.4 -1.0 -0.0 -1.6 -0.4 0.6 -1.3 -1.9
Qualifications: A levels/AS levels or equivalent 0.6 1.3 4.8 -0.3 -1.3 1.4 -0.0 -1.3 1.3 -0.1 -0.7 2.2 -0.4 -1.2
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 3.5 0.1 -0.9 -0.1 0.4 1.9 0.1 -0.2 -0.1 0.1 -0.1 0.9
Mouth/teeth dental problems: Dentures 0.3 0.4 2.2 0.3 1.5 -0.2 -0.7 0.4 0.2 0.9 0.5 0.2 0.6 0.4
Asthma 1.8 3.5 7.6 -2.1 -1.9 -1.1 -1.8 1.2 -1.0 -2.8 -2.7 0.1 -2.8 -0.5
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 4.0 -0.7 0.5 -0.7 -2.0 2.0 0.0 -0.5 -1.0 0.5 -0.6 -0.1
Medication: Cholesterol lowering 1.1 1.7 3.6 -1.8 -1.7 -0.7 0.6 0.5 0.7 -1.9 -0.9 0.3 -1.7 -1.9
Depression (self-reported) 0.6 0.7 3.6 -0.4 0.7 -0.2 1.4 0.0 -0.2 0.0 0.6 -1.9 0.1 1.0
Medication: Lansoprazole 1.4 1.6 5.1 -1.0 -0.3 -0.4 -0.6 -2.3 -1.0 -1.8 -1.3 0.1 -1.8 -1.3
Prospective memory result 1.4 1.7 4.1 -1.8 -0.8 -0.6 0.9 0.1 -1.4 -1.8 -0.6 -1.4 -1.5 -2.0
Lung cancer (father) 1.3 1.5 4.1 1.7 1.0 0.3 0.5 -0.7 -1.4 1.1 1.5 -2.0 1.1 -1.1
Illnesses of mother 1.2 1.4 11.5 0.3 -0.3 0.7 0.9 -0.2 3.4 0.7 -0.1 1.0 0.6 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 2.0 6.5 16.7 4.1 2.0 2.6 1.4 0.3 -0.2 3.7 3.5 1.4 3.6 1.0
Pulse wave Arterial Stiffness index 1.1 1.3 3.6 0.9 1.4 0.4 -1.9 0.5 1.3 1.1 1.1 0.6 0.9 1.5
Impedance of arm (left) 0.7 3.4 11.2 0.9 -0.5 1.7 2.4 -3.3 2.8 1.0 0.6 2.6 0.7 0.8
Arm fat mass (right) 3.6 15.0 29.6 -4.5 -3.2 -4.7 -3.8 1.3 -3.4 -5.4 -3.7 -1.0 -5.1 -3.8
Trunk predicted mass 0.3 1.7 8.5 -0.1 -0.2 -0.9 -1.8 2.9 -2.2 -0.2 0.3 -0.3 -0.1 -1.2
Standing height 0.3 2.9 6.6 2.4 0.3 1.5 1.4 0.8 0.7 2.3 2.1 2.6 2.1 0.3
Length of working week for main job 2.0 2.2 6.5 1.3 1.1 0.9 1.2 -2.1 2.5 1.0 0.8 2.4 1.0 0.4
Exposure to tobacco smoke at home 0.2 0.2 0.7 -0.5 0.6 0.1 -0.3 0.3 0.1 -0.8 -0.6 -0.1 -0.8 -0.1
Breastfed as a baby 1.0 1.2 2.2 -1.3 -0.6 -0.8 -0.0 -1.5 -0.5 -1.4 -0.8 -1.3 -1.2 -1.4
Tense / ‘highly strung’ 0.8 1.3 7.1 -0.9 -1.3 0.1 1.4 -2.7 0.5 -0.2 -0.1 1.3 -0.5 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.6 4.0 6.4 -2.5 -1.6 -1.9 -1.5 0.3 -2.3 -2.5 -2.0 -2.2 -2.3 -1.9
Hair/balding pattern: Pattern 4 0.8 2.0 4.7 -2.1 -1.2 -1.5 -0.9 -1.0 -1.2 -1.5 -0.9 0.5 -1.4 -2.2
Birth weight of first child 0.2 0.4 1.6 0.6 -1.3 0.5 0.7 -0.9 -0.6 -0.2 -0.2 -0.2 -0.2 -0.8
Peak expiratory flow (PEF) 0.9 2.0 5.6 1.1 0.2 2.4 1.9 0.8 -1.1 1.2 1.5 1.6 1.0 -1.7
Pulse wave reflection index 0.3 0.4 2.2 -0.3 0.6 0.5 -0.9 -1.5 0.2 -0.2 -0.4 0.4 -0.2 0.3
Ever highly irritable/argumentative for 2 days 0.5 0.6 3.5 0.2 -0.1 0.2 1.2 -1.9 0.7 -0.4 -0.5 -0.3 -0.2 -0.7
Loud music exposure frequency 0.7 0.8 3.0 -0.5 0.2 0.6 0.1 1.4 -1.7 -0.1 -0.2 -1.4 -0.3 0.7
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 2.2 -0.1 0.2 0.5 -0.1 -1.5 -0.0 -0.3 -0.5 0.4 -0.3 -1.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 2.3 1.5 -0.9 0.4 0.9 0.8 0.1 0.7 0.9 0.2 1.0 0.3
Blood clot in the leg (DVT) 1.0 1.3 3.3 -1.0 1.4 -1.8 -1.2 -0.2 -1.1 -1.2 -0.8 -0.5 -1.1 -1.5
Medication: Paracetamol 1.1 1.8 5.7 -1.8 -0.4 -1.5 -0.2 0.0 -2.4 -1.6 -1.6 -1.0 -1.5 -0.5
Headache pain in last month 0.2 0.3 1.6 0.0 0.0 -0.5 -0.3 -0.6 -1.2 -0.0 -0.1 -0.5 0.2 -0.6
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.7 1.0 1.0 -0.1 -0.8 -1.2 -0.2 1.2 0.0 0.3 0.9 1.3
Glaucoma (self-reported) 0.2 0.2 0.9 -0.3 -0.1 0.1 -0.7 0.1 -0.9 -0.2 -0.3 -0.2 -0.5 -0.3
Gout (self-reported) 2.2 3.0 6.3 -2.5 -2.0 -2.0 0.2 -0.5 -0.2 -2.0 -1.6 -2.0 -2.1 -1.7
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 2.2 0.2 1.1 0.4 0.6 0.7 -1.1 -0.1 0.2 -1.5 -0.1 -1.2
Medication: Amlodipine 0.5 0.6 3.0 -0.8 -0.2 -0.0 0.3 -0.7 -1.3 -0.8 0.5 -0.1 -0.4 -1.7
Medication: Ventolin 100micrograms inhaler 1.7 2.2 6.5 -2.5 -1.9 -0.4 -0.8 0.9 -0.7 -2.1 -1.6 1.2 -1.9 -0.2
Birth weight 0.1 0.3 1.2 -0.5 -0.2 0.4 -1.1 1.1 -0.2 -0.5 -0.5 0.0 -0.3 0.0
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.8 -0.8 0.6 0.3 1.1 0.2 -1.3 -0.7 0.1 -0.4 -0.4 -0.7
High blood pressure (siblings) 0.4 0.6 1.9 -0.2 -0.7 0.3 1.4 -0.3 -0.2 -0.7 -0.3 -1.4 -0.6 -1.1
Forced vital capacity (FVC), Best measure 1.7 6.4 15.7 4.0 2.0 2.4 0.9 0.8 0.3 3.7 3.2 1.6 3.5 2.0
Body fat percentage 4.1 16.2 33.6 -5.0 -3.8 -4.9 -3.4 0.3 -3.0 -5.8 -4.0 -0.8 -5.6 -3.6
Leg fat percentage (right) 4.4 15.8 29.1 -4.9 -3.1 -5.1 -3.8 0.4 -3.5 -5.4 -3.7 -1.8 -5.2 -3.8
Arm fat-free mass (right) 0.5 2.4 6.5 -0.8 -1.0 -1.8 -2.0 2.5 -2.3 -1.1 -0.4 -0.9 -1.0 -1.6
Exposure to tobacco smoke outside home 0.3 0.5 1.1 0.7 1.0 1.0 0.9 0.5 -0.6 0.6 0.5 0.3 0.4 -0.4
Comparative body size at age 10 0.6 1.6 4.3 -0.9 -2.1 -0.3 -1.3 1.9 -1.3 -1.3 0.1 0.0 -0.9 -1.8
Number of full brothers 0.3 0.3 1.3 -0.6 0.1 -0.5 -1.2 0.8 -0.2 -0.7 0.2 -0.1 -0.5 -0.4
Worry too long after embarrassment 0.3 0.4 1.1 -0.7 0.3 -1.0 -0.8 0.9 -0.9 -0.1 0.2 -0.2 -0.1 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 4.7 -1.5 -1.3 -1.6 -0.9 0.3 -2.2 -1.7 -1.4 -1.4 -1.4 -1.3
Wheeze or whistling in the chest in last year 2.4 4.3 10.1 -2.7 -1.7 -1.8 -3.2 0.1 -1.7 -2.5 -2.8 -0.6 -2.6 -0.3
Number of children fathered 3.3 3.7 11.3 -1.7 -1.3 -1.6 0.6 1.3 -2.1 -2.6 -1.6 0.6 -2.5 -3.4
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 1.0 0.3 0.8 0.1 0.1 0.4 -0.2 0.1 0.6 1.0 0.4 -0.1
Age at first live birth 0.9 1.6 8.6 -0.1 -2.9 0.7 0.0 -1.8 -0.5 -0.2 -0.4 1.0 -0.5 -1.7
Pulse wave peak to peak time 1.0 1.2 3.5 -0.8 -1.3 -0.5 1.9 -0.4 -1.3 -1.0 -1.0 -0.4 -0.8 -1.5
Health satisfaction 1.1 1.4 3.3 -1.2 -1.4 -0.9 -1.7 0.5 0.1 -1.4 -1.8 0.5 -1.7 -0.4
Shortness of breath walking on level ground 1.7 2.1 4.5 -1.5 -1.4 -0.5 -1.5 0.0 -0.3 -2.0 -1.6 -0.9 -1.9 -2.1
Qualifications: College or University degree 0.4 1.3 4.7 0.7 -1.6 2.2 1.2 0.5 0.9 1.2 0.1 1.4 0.7 0.7
Eye problems/disorders: None of the above 1.3 1.5 7.7 0.5 0.3 0.4 1.4 0.4 2.8 0.8 0.3 1.5 1.6 1.0
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.4 0.5 0.3 0.1 0.3 0.9 -0.3 0.9 1.2 -1.1 1.1 0.9
Emphysema/chronic bronchitis 0.7 0.8 4.4 -0.2 -1.0 0.6 0.5 -0.4 -1.1 0.5 0.7 -2.1 0.6 -0.2
Medication for pain relief, constipation, heartburn 0.4 0.7 1.6 0.5 -1.2 0.3 1.0 -1.3 1.3 0.3 0.8 0.5 0.6 0.3
Neck or shoulder pain in last month 0.4 0.5 1.4 -0.8 0.5 -0.7 -1.2 -0.6 -0.6 -0.6 -0.5 -0.8 -0.7 -0.4
Medication: Blood pressure 0.6 1.1 5.3 -0.9 -0.7 -0.3 0.8 1.0 -0.4 -1.2 0.4 -1.3 -0.8 -2.3
Angina (self-reported) 1.2 1.6 4.7 -0.9 0.1 -1.0 -1.3 -1.5 -1.0 -1.3 -1.4 -2.2 -1.3 -1.0
Migraine (self-reported) 0.6 0.8 3.2 0.3 0.8 -0.3 1.3 1.2 -1.8 0.5 0.7 -0.7 0.5 0.5
Medication: Ibuprofen 0.8 1.0 6.2 0.0 0.8 -0.9 -1.4 2.5 -0.8 -0.0 -0.3 -0.4 -0.1 0.3
Medication: Allopurinol 2.3 3.1 8.3 -1.8 -1.9 -2.5 -0.3 1.5 0.1 -2.0 -1.0 -2.9 -2.0 -1.1
Medication: Omeprazole 0.6 0.7 1.7 -0.9 -0.4 -0.6 0.1 -0.7 -1.0 -1.2 -0.5 -0.4 -1.3 -1.0
Medication: Seretide 50 evohaler 0.9 1.1 2.7 1.3 1.1 1.4 1.1 -0.5 -0.7 1.2 1.6 0.2 1.0 0.1
Mean time to correctly identify matches 0.7 1.4 4.1 -1.1 -1.5 -2.0 -1.6 1.1 -0.6 -1.1 -0.6 -0.2 -1.1 1.0
Heart disease (mother) 0.7 0.8 3.1 -0.7 -0.4 -0.6 0.7 -0.2 -1.2 -0.9 -0.3 -1.8 -0.6 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.9 0.4 -0.2 1.4 0.4 0.7 -1.1 -0.1 -0.2 -0.5 0.0 0.1
Whole body fat mass 3.8 15.7 30.4 -4.6 -3.7 -4.8 -3.7 1.2 -3.5 -5.5 -3.8 -1.0 -5.3 -3.8
Leg fat mass (right) 3.8 14.9 27.4 -4.7 -3.3 -4.7 -3.6 1.2 -3.7 -5.2 -3.3 -1.2 -5.0 -4.0
Arm predicted mass (right) 0.5 2.4 7.1 -0.7 -0.6 -1.6 -2.3 2.7 -2.4 -1.0 -0.3 -1.0 -0.9 -1.6
Pulse rate, automated reading 0.2 0.5 2.5 -0.0 -0.1 -0.5 -1.1 0.4 1.6 -0.1 0.5 0.2 0.1 1.2
Alcohol intake frequency. 1.5 3.5 9.1 -3.0 -1.5 -0.4 1.1 -0.3 -1.4 -3.0 -2.0 -0.2 -2.6 -2.0
Comparative height size at age 10 0.3 1.6 8.8 -0.6 -1.6 -1.2 -0.6 1.1 -0.5 -1.0 -0.5 0.5 -1.1 -3.0
Number of full sisters 0.6 0.7 4.1 -0.2 0.2 -0.1 1.1 2.0 -0.5 -0.3 0.5 -1.0 0.0 0.6
Suffer from ‘nerves’ 0.6 0.9 2.4 -1.2 -1.1 -0.6 -0.8 -0.7 -1.6 -0.8 -1.2 0.5 -0.7 -1.0
Overall health rating 0.7 1.5 5.6 -0.9 -0.1 -0.2 -0.4 -1.2 0.2 -1.4 -0.8 2.4 -1.2 -2.0
Chest pain or discomfort 0.3 0.4 1.3 -0.2 0.0 0.3 -0.9 -0.5 -1.0 -0.4 -0.5 0.0 -0.4 -1.2
Had major operations 3.4 3.9 9.0 -2.6 -0.3 -1.7 -3.0 1.4 -2.5 -2.0 -2.3 -1.0 -2.1 -1.4
Age at last live birth 1.1 1.6 6.0 -0.9 -2.1 0.2 0.3 -1.6 -1.2 -0.8 -0.8 0.2 -0.8 -2.4
Family relationship satisfaction 0.4 0.5 2.1 -0.2 -0.7 -1.4 -1.5 -0.8 -0.1 -0.3 -0.5 -0.2 -0.4 0.3
Leg pain on walking 1.4 1.8 3.9 -1.0 -1.0 -0.3 -1.5 -0.8 -1.8 -1.3 -1.3 -0.9 -1.8 -2.0
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 6.1 0.8 1.7 0.9 2.5 0.3 0.7 0.4 1.3 -0.2 0.7 -1.0
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.6 -0.8 0.7 -0.3 0.4 -1.1 -0.4 0.1 0.9 1.6 0.2 -1.1
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.2 -1.1 -0.8 0.0 -1.0 -0.1 0.6 -0.4 -1.1 0.6 -0.4 -0.6
Medication: Aspirin 1.2 1.6 4.2 1.4 1.8 1.0 1.4 0.0 -0.4 1.5 2.1 -1.0 1.5 0.4
Supplements: Vitamin C 0.8 1.0 3.6 -1.6 -1.9 -0.5 -0.5 0.2 -0.3 -0.9 -0.9 -0.9 -0.7 -1.0
Knee pain experienced in last month 1.3 2.1 7.5 0.5 -0.1 0.2 -2.2 -1.8 -1.7 -0.9 -1.2 -0.3 -1.0 -2.7
Hypertension (Self-reported) 0.5 1.3 3.8 0.3 0.0 1.0 -0.0 1.3 -1.9 -0.4 0.4 -1.9 -0.2 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 5.3 -1.1 -0.4 -0.2 -1.1 -2.3 -1.0 -1.6 -1.6 1.0 -1.5 -2.0
Illnesses of father: Heart disease 1.8 2.4 9.9 -1.1 -1.6 -0.4 1.8 -0.4 -1.9 -1.7 -0.3 -0.5 -1.6 -3.1
Illnesses of siblings: Diabetes 0.3 0.4 1.8 -0.6 -0.1 -0.5 0.3 -0.6 -0.5 -0.9 -0.1 -0.5 -0.6 -1.4
Smoking status: Previous 0.5 0.7 3.3 0.9 -0.1 -0.4 -1.3 -1.8 -0.5 0.7 0.5 -0.4 0.7 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 5.0 1.8 0.9 0.6 0.4 -0.4 0.4 2.1 1.5 2.2 1.8 1.0
Whole body fat-free mass 0.4 2.2 9.5 -0.7 -0.6 -1.0 -1.8 3.1 -2.4 -0.9 -0.1 -0.2 -0.8 -1.6
Leg fat-free mass (right) 0.6 3.0 7.4 -1.5 -1.6 -1.2 -1.5 2.7 -2.5 -1.9 -0.7 0.3 -1.7 -1.9
Arm fat percentage (left) 4.1 16.2 33.9 -4.9 -3.4 -4.8 -3.5 0.4 -3.2 -5.8 -4.0 -0.8 -5.6 -3.9
Average weekly red wine intake 0.6 0.9 2.0 1.1 -0.0 1.4 -0.1 1.4 0.4 1.4 1.1 0.4 1.2 -0.3
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.4 0.8 -0.4 -0.0 -0.3 -0.6 1.2 0.8 0.8 0.3 1.1 0.8
Mood swings 0.5 1.0 3.7 -0.7 0.8 -1.4 -1.3 0.0 -1.3 -0.4 -0.3 -1.9 -0.5 0.3
Loneliness, isolation 0.7 1.0 2.4 -0.6 -0.3 -1.2 -0.8 -1.5 0.2 -1.2 -1.0 -0.3 -1.2 -1.5
Long-standing illness, disability or infirmity 1.5 2.3 5.2 -1.7 -0.4 -1.8 -1.4 -0.6 -0.5 -2.3 -1.6 -1.7 -2.2 -1.1
Ever had bowel cancer screening 2.4 2.8 4.9 -1.4 -2.2 -0.9 -1.9 -0.4 -2.1 -1.7 -2.1 -1.5 -2.0 -0.9
Diabetes diagnosed by doctor 0.4 0.7 1.9 0.8 0.6 0.8 1.4 0.5 -0.8 0.2 1.4 -0.5 0.2 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.7 -0.5 0.4 -0.7 0.4 0.3 0.3 -0.6 -0.2 0.8 -0.2 -0.3
Friendships satisfaction 0.4 0.5 1.3 0.2 -1.1 -0.8 -0.9 -0.1 -0.4 -0.5 -0.8 -0.8 -0.6 -0.1
Qualifications: nursing, teaching 0.5 0.8 3.4 0.4 -0.8 1.8 -0.1 -1.5 0.1 0.5 0.3 1.2 0.3 -0.5
Commuting to job workplace: Walk 1.1 1.1 4.2 0.9 0.3 0.4 -0.7 1.1 2.0 0.8 0.1 0.4 0.7 2.1
Eye problems/disorders: Cataract 1.0 1.2 4.4 -0.7 -0.4 -0.0 -1.3 -1.2 -2.1 -0.8 -0.9 -0.7 -1.5 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 7.0 1.1 0.2 0.2 0.9 0.5 -2.6 1.1 1.3 -1.2 1.3 0.2
Medication for cholesterol 0.7 1.1 2.6 1.5 0.0 0.0 1.0 0.3 1.6 1.4 1.5 -0.4 1.3 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.5 2.9 8.2 -1.4 0.3 -2.3 -1.0 2.4 -1.1 -1.9 -1.2 -2.9 -1.7 -0.4
Back pain experienced in last month 1.2 1.7 7.1 -0.0 1.2 -0.2 0.3 0.3 -2.7 -1.1 0.1 -2.2 -1.0 -1.7
Mineral and other dietary supplements 0.5 0.7 2.2 0.7 0.4 0.9 0.5 -0.2 1.5 0.7 0.2 1.5 0.8 0.5
Breast cancer (self-reported) 0.3 0.3 1.0 -0.8 -0.4 -0.9 -0.6 0.7 0.1 -0.0 -0.2 0.3 -0.3 1.0
Asthma (self-reported) 2.0 3.9 8.8 -2.5 -2.1 -1.0 -1.8 1.1 -1.1 -3.0 -2.9 0.2 -2.9 -0.7
Osteoporosis (self-reported) 0.2 0.2 1.0 0.3 0.6 1.0 0.3 -0.3 0.3 -0.0 -0.6 0.0 -0.2 -0.4
Osteoarthritis (self-reported) 1.9 2.5 5.4 -1.3 -1.1 -2.0 -2.3 -0.9 -1.5 -1.7 -1.2 -1.4 -1.8 -1.5
Medication: Aspirin 0.9 1.2 3.0 1.1 1.2 1.1 1.3 -0.1 -0.8 1.1 1.7 -1.2 1.0 0.1
Medication: Gliclazide 1.2 1.3 6.5 -0.1 0.1 0.0 1.9 -1.7 1.2 -0.3 0.5 0.3 -0.0 -2.5
Illnesses of father: None of the above (group 1) 1.9 2.4 5.5 1.8 2.2 0.0 -1.7 0.2 2.4 2.0 0.6 0.7 1.8 1.2
Smoking status: Current 1.1 1.7 5.6 -1.4 -0.2 -1.1 -2.4 -1.8 0.8 -1.0 -0.9 -0.2 -1.0 -1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 3.7 1.7 0.2 0.9 0.2 1.5 0.0 1.5 1.9 0.6 1.5 0.9
Whole body water mass 0.4 2.1 8.4 -0.7 -0.5 -1.2 -1.8 2.9 -2.4 -0.9 -0.1 -0.3 -0.8 -1.6
Leg predicted mass (right) 0.5 2.9 7.3 -1.5 -1.5 -1.2 -1.4 2.7 -2.4 -1.9 -0.7 0.3 -1.7 -1.9
Arm fat mass (left) 3.4 14.1 26.8 -4.2 -3.2 -4.6 -3.8 1.1 -3.4 -5.2 -3.5 -1.1 -4.9 -3.8
Number of self-reported non-cancer illnesses 0.8 1.4 4.5 -1.1 -0.3 0.1 -0.3 0.3 -2.1 -1.5 -0.9 -1.8 -1.4 -1.1
Average weekly champagne plus white wine intake 2.4 3.2 6.9 2.6 1.4 1.1 1.9 -0.6 1.5 2.3 2.0 0.6 2.6 1.7
Miserableness 0.4 0.6 3.0 0.1 0.6 -0.8 -1.4 0.4 -0.7 0.2 0.2 -1.7 0.1 -0.6
Guilty feelings 0.2 0.3 1.3 0.2 0.5 0.2 1.1 -0.4 0.0 -0.0 0.7 0.6 0.1 -1.0
Wears glasses or contact lenses 2.3 2.7 10.1 -0.9 -1.6 -1.6 -1.0 0.3 -3.2 -1.8 -0.8 -2.3 -1.8 -0.8
Ever taken oral contraceptive pill 0.6 0.6 3.2 0.8 0.2 0.3 1.2 -1.8 0.0 0.9 0.6 0.1 0.6 0.4
Hearing aid user 0.8 0.8 2.7 -0.8 0.9 -1.6 -1.4 0.6 -0.3 -0.8 -0.4 -1.0 -0.8 -0.7
Mother’s age at death 0.2 0.2 0.6 0.2 -0.1 -0.2 0.7 -0.8 -0.4 -0.3 -0.6 0.2 -0.4 0.3
Financial situation satisfaction 1.4 1.7 4.5 -1.5 -0.9 -0.7 -1.1 -1.1 1.5 -1.6 -2.1 0.2 -1.9 -0.2
Tinnitus: Yes, now most or all of the time 1.0 1.2 4.8 -0.4 -0.2 -0.2 -0.4 1.7 -2.2 -0.5 0.6 -2.0 -0.4 0.4
Commuting to job workplace: Public transport 0.5 0.5 1.9 0.0 -1.4 -0.5 -0.3 1.1 -0.7 -0.3 -0.7 -0.2 -0.6 1.1
Eye problems/disorders: Glaucoma 0.3 0.3 1.4 -0.2 0.6 -0.1 -0.7 -0.1 -0.4 -0.0 -0.1 -0.7 -0.5 -1.2
Medication: Blood pressure 0.3 0.5 1.8 -0.1 0.7 0.9 -1.1 0.8 -1.4 0.1 0.1 -0.8 0.3 0.4
Pain type(s) experienced in last month: Hip pain 1.6 2.0 4.0 -1.4 -2.0 -0.9 -0.7 0.7 -1.7 -1.5 -1.1 -1.2 -1.6 -1.9
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.3 -0.1 -0.5 0.3 0.1 1.1 -0.7 0.2 0.4 -1.1 0.0 0.5
High cholesterol (Self-reported) 0.4 0.8 1.7 -0.1 -0.9 0.1 -0.2 -0.3 1.3 -1.0 -1.0 1.3 -0.9 -1.2
Medication: Bendroflumethiazide 0.5 0.7 1.6 -0.9 -0.7 -0.2 -1.1 0.1 -0.6 -1.3 -1.0 -0.8 -1.1 -0.6
Medication: Paracetamol 0.6 0.9 5.4 -0.8 -0.2 -1.0 0.0 0.3 -2.3 -0.7 -0.6 -1.3 -0.6 0.0
Medication: Lisinopril 0.4 0.5 1.9 0.1 0.2 0.0 0.9 0.9 0.3 0.3 1.2 -1.4 0.5 -0.3
Medication: Atorvastatin 0.8 1.0 3.5 1.4 0.3 1.9 -0.3 0.0 -1.4 0.8 1.5 -0.2 1.0 -0.4
Illnesses of father: High blood pressure 1.2 1.5 6.5 -0.8 -1.8 -0.5 -0.3 1.1 -2.5 -0.9 -0.7 -0.1 -1.3 1.2
Alcohol drinker status: Never 0.6 0.7 3.7 -1.2 -0.1 0.2 1.9 0.0 0.5 -1.1 0.2 0.7 -0.7 -0.4
Ever smoked 0.8 1.4 7.7 0.0 -0.2 -1.0 -2.8 -1.7 -0.9 0.0 0.0 -1.6 0.2 -0.3
Basal metabolic rate 0.6 3.3 7.1 -1.4 -1.1 -1.8 -2.2 2.6 -2.7 -1.7 -0.7 -0.3 -1.6 -2.2
Leg fat percentage (left) 4.6 16.6 30.8 -5.0 -3.7 -5.2 -3.9 0.5 -3.6 -5.5 -3.8 -1.7 -5.3 -3.6
Arm fat-free mass (left) 0.6 3.2 8.5 -1.0 -0.8 -2.0 -2.4 2.9 -2.7 -1.4 -0.6 -1.1 -1.3 -1.6
Number of operations (self-reported) 4.8 7.2 14.7 -3.8 -0.4 -2.6 -2.6 -0.7 -2.6 -3.1 -2.4 -2.4 -3.0 -3.6
Average weekly beer plus cider intake 0.5 0.8 3.5 1.2 0.4 0.3 0.8 -0.5 -0.5 0.5 1.0 0.6 0.8 -1.9
Irritability 1.2 2.1 13.8 -0.1 -0.6 -0.5 -0.1 -3.7 -1.8 0.4 0.8 -0.2 0.1 -2.2
Risk taking 0.1 0.1 0.4 0.6 -0.6 -0.5 0.1 0.0 0.3 0.1 0.1 0.4 -0.2 -0.3
Ever had prostate specific antigen (PSA) test 0.6 0.7 4.4 0.5 -0.0 -0.1 -0.2 -0.1 0.4 0.2 -0.3 2.1 0.0 -1.5
Fractured/broken bones in last 5 years 0.7 0.9 4.5 0.9 0.3 0.2 -0.2 2.1 0.3 0.8 1.2 -0.5 0.9 1.2
Age started oral contraceptive pill 0.5 0.6 2.3 -0.6 -0.6 -0.6 -0.7 -0.8 -0.1 -0.8 -1.5 -0.7 -1.0 0.4
Diastolic blood pressure, automated reading 0.6 1.8 6.5 -0.3 -1.8 -1.4 -2.0 1.1 -2.5 -1.1 -0.4 -0.6 -1.1 -0.4
Ever depressed for a whole week 0.7 0.9 3.1 1.0 0.6 1.3 -0.1 0.5 0.5 0.9 1.1 -0.6 1.0 1.7
Unable to work because of sickness or disability 1.5 1.9 5.4 -2.2 -0.5 -1.2 -0.7 -0.1 0.3 -2.1 -2.3 0.3 -2.0 -0.6
Commuting to job workplace: Cycle 0.8 1.0 5.3 -0.2 -1.1 0.0 -0.7 2.3 0.9 0.2 -0.5 0.4 0.1 1.5
Myopia 1.4 2.0 4.6 -1.8 -2.1 -0.2 -1.9 -0.7 0.2 -1.6 -1.6 1.4 -1.4 -0.8
Vascular/heart problems diagnosed by doctor 0.6 1.5 5.5 0.3 0.5 -0.4 0.2 -1.0 2.4 1.1 0.1 2.1 0.9 1.8
Cholesterol lowering medication 0.5 0.7 3.1 -0.6 0.4 -0.1 -1.0 0.1 -1.4 -0.6 -0.9 -0.1 -0.6 -1.8
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 3.9 -1.1 -1.6 -0.4 0.1 -0.3 -1.1 -1.7 -0.9 -0.9 -2.0 -1.1
Pain experienced in last month 1.2 2.0 4.8 0.6 -0.2 0.7 1.2 1.6 2.2 1.3 1.0 1.7 1.3 2.1
Supplements: Calcium 1.2 1.3 3.1 -1.6 -1.3 -0.5 -0.8 -0.7 -0.5 -1.4 -1.8 -0.3 -1.5 -0.9
Basal cell carcinoma (self-reported) 1.6 1.9 5.4 1.1 1.8 0.9 1.1 -2.3 1.0 1.4 0.6 1.9 1.4 -0.1
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.3 -0.4 -0.2 0.2 0.6 -0.2 0.5 -0.2 0.4 0.3 -0.2 -0.2
Deep venous thrombosis (DVT) (self-reported) 1.1 1.5 3.2 -1.2 1.3 -1.8 -1.3 0.1 -0.9 -1.4 -0.9 -0.6 -1.3 -1.5
Heart disease (siblings) 1.3 1.6 7.6 0.6 2.8 1.1 2.1 -0.1 0.7 0.6 1.1 -1.1 0.5 -0.0
Alcohol drinker status: Previous 0.6 0.7 1.9 -1.0 -0.8 -0.8 1.4 -1.0 0.5 -1.0 -0.5 -0.2 -0.7 -0.4
Pack years of smoking 0.5 0.7 1.9 -1.3 -0.2 -1.0 0.0 0.5 -0.2 -1.4 -0.2 -0.8 -1.1 -0.6
Impedance of whole body 0.8 3.9 11.2 1.1 -0.5 1.7 2.6 -3.4 3.0 1.4 0.8 2.3 1.3 1.5
Leg fat mass (left) 3.9 15.3 28.7 -4.8 -3.6 -4.7 -3.5 1.0 -3.6 -5.4 -3.4 -1.2 -5.1 -4.0
Arm predicted mass (left) 0.6 2.8 7.1 -1.0 -0.7 -1.8 -2.3 2.6 -2.7 -1.3 -0.6 -1.1 -1.1 -1.6