TWAS hub - GSN

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.3620	0.1220	6.3e-03	-0.012	NA	0.031	NA	0.005	9.8e-01	NA	5.6e-02	NA	2.4e-01
2	NTR	Blood	0.0603	0.0156	3.9e-16	0.071	0.057	0.063	0.070	0.069	7.8e-22	6.3e-18	1.4e-19	1.4e-21	2.2e-21
3	YFS	Blood	0.1361	0.0259	0.0e+00	0.156	0.137	0.154	0.148	0.154	1.7e-48	1.6e-42	4.5e-48	5.2e-46	5.7e-48
4	TCGA	Breast Invasive Carcinoma	0.0217	0.0154	7.8e-03	0.012	0.006	0.009	NA	0.003	1.5e-03	1.9e-02	5.4e-03	NA	6.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Osteoarthritis (self-reported)	3.6	4.7	7.4	2.7	1.9	2.0	2.0
Medication: Ibuprofen	3.0	3.5	7.4	0.7	1.6	1.9	2.7
Diabetes (father)	2.9	3.5	7.1	0.1	-2.2	-2.7	-1.5
Diabetes (mother)	2.9	3.7	5.1	-1.4	-2.2	-2.0	-1.9
Blood Platelet Count	2.7	31.3	36.4	5.6	5.3	6.0	5.4
Alcohol intake versus 10 years previously	2.6	3.9	5.0	2.2	1.6	2.0	1.9
Illness, injury, bereavement, stress in last 2 years	2.6	3.2	4.8	0.6	1.9	2.0	2.2
Commuting to job workplace: Walk	2.6	2.9	4.3	0.2	-2.1	-2.0	-1.8
Financial difficulties in last 2 years	2.5	3.3	5.9	-0.2	-2.0	-2.4	-1.8
Mouth/teeth dental problems: Bleeding gums	2.5	3.2	6.2	0.3	1.8	1.9	2.5
Pulse rate, automated reading	2.5	8.2	12.2	2.9	2.5	3.5	2.3
Commuting to job workplace: Car/motor vehicle	2.5	2.9	4.1	1.6	2.0	1.7	1.4
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	5.3	1.2	1.4	1.7	2.3
Emphysema/chronic bronchitis	2.3	2.6	3.8	-0.6	-1.6	-2.0	-1.9
Hearing aid user	2.3	2.6	4.9	-0.9	-1.8	-1.3	-2.2
Pain experienced in last month	2.3	3.8	6.6	-0.7	-2.2	-1.8	-2.6
Pain all over the body in last month	2.0	2.2	2.9	1.2	-1.3	-1.6	-1.7
Number of children fathered	2.0	2.2	5.1	-0.6	1.4	1.2	2.3
Pulse wave peak to peak time	2.0	2.3	4.1	-0.9	-1.2	-2.0	-1.7
Medication: Omeprazole (e.g. Zanprol)	2.0	2.5	3.9	-0.5	2.0	1.7	1.7
Depression (self-reported)	1.9	2.3	3.3	-0.3	-1.5	-1.8	-1.8
Noisy workplace	1.8	2.3	3.6	-0.6	-1.9	-1.5	-1.7
Pulse wave Arterial Stiffness index	1.8	2.2	4.0	0.9	1.1	2.0	1.6
Family relationship satisfaction	1.8	2.3	4.0	2.0	1.2	1.0	1.7
Number of self-reported non-cancer illnesses	1.8	3.2	4.5	2.1	1.8	1.4	1.7
Mother’s age at death	1.8	2.3	3.8	0.3	1.9	1.9	1.3
Medication: Bendroflumethiazide	1.8	2.7	3.8	1.7	1.9	1.8	0.8
Impedance of leg (right)	1.7	8.2	13.5	-1.0	-3.7	-3.3	-2.8
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	4.8	-2.2	-1.2	-1.0	-1.0
Impedance of leg (left)	1.6	7.7	11.9	-1.0	-3.5	-3.2	-2.8
Basal cell carcinoma (self-reported)	1.6	1.9	3.8	1.1	-1.2	-1.9	-1.0
Alzheimer’s Disease (in father)	1.5	1.6	4.9	2.2	1.0	0.6	0.5
Bipolar Disorder (2011)	1.5	1.4	2.4	-0.3	1.2	1.3	1.5
Townsend deprivation index at recruitment	1.5	2.1	3.7	-1.0	-1.9	-1.4	-1.3
Ovarian Cancer	1.4	1.9	2.9	0.7	1.7	1.6	1.2
Mouth/teeth dental problems	1.4	2.2	3.5	-0.7	-1.8	-1.9	-1.2
Alcohol drinker status: Previous	1.4	1.6	2.9	-0.4	-1.3	-1.2	-1.7
Blood Red Count	1.3	12.5	20.7	-2.2	-3.6	-4.5	-3.4
Hand grip strength (left)	1.3	3.4	5.2	-2.3	-1.3	-1.6	-2.0
Hand grip strength (right)	1.3	3.5	6.7	-2.6	-1.7	-1.6	-1.4
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.2	-0.1	1.0	1.2	1.8
Asthma	1.3	2.5	9.6	3.1	0.1	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	4.9	-1.9	-2.1	-2.2	-1.8
Birth weight of first child	1.3	2.3	5.7	2.4	0.8	1.1	1.2
Chronic bronchitis/emphysema (mother)	1.3	1.5	5.2	2.3	0.2	0.9	-0.2
Medication for pain relief, constipation, heartburn	1.3	2.2	3.8	-1.9	-0.9	-1.2	-1.6
Medication: Omeprazole	1.3	1.5	2.6	0.0	1.6	1.3	1.3
Leg pain on walking	1.3	1.6	2.6	0.5	1.4	1.6	1.2
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	3.4	0.5	1.5	1.4	1.8
Ever taken oral contraceptive pill	1.3	1.5	2.7	-1.0	1.2	1.6	1.0
Fractured/broken bones in last 5 years	1.3	1.6	3.4	0.0	1.4	1.1	1.8
Schizophrenia vs Biploar Disorder	1.2	1.6	2.5	-0.1	-1.4	-1.4	-1.6
Breast Cancer	1.2	2.9	6.0	0.9	1.8	2.4	1.2
Supplements: Glucosamine	1.2	1.5	3.1	0.8	0.9	1.8	1.3
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.8	1.7	-0.7	-1.3	-0.8
Lung cancer (father)	1.2	1.4	2.0	1.0	1.4	1.4	0.7
Age at last live birth	1.2	1.7	3.0	-0.1	-1.4	-1.7	-1.4
Illnesses of siblings: Diabetes	1.2	1.4	2.8	1.0	-1.7	-1.4	-0.1
Breast cancer (self-reported)	1.2	1.5	2.7	0.1	-0.9	-1.7	-1.5
Asthma (self-reported)	1.2	2.3	8.9	3.0	0.4	-0.3	-0.5
Illnesses of father: None of the above (group 1)	1.2	1.4	1.8	0.7	1.3	1.4	1.3
Irritability	1.2	2.1	3.6	0.2	1.9	1.8	1.1
Reaction Time	1.1	2.1	3.8	2.0	-1.1	-1.6	-1.0
Neuroticism (2016)	1.1	1.6	2.7	0.6	1.6	1.3	1.3
Ever had hysterectomy (womb removed)	1.1	1.2	2.5	-0.7	-1.6	-1.1	-0.9
Angina	1.1	1.4	3.0	-0.3	-1.2	-1.7	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	3.8	0.0	-2.0	-1.8	-1.7
Pulse rate	1.1	1.8	3.3	0.9	1.4	1.8	1.2
Forced vital capacity (FVC), Best measure	1.1	3.9	4.4	-2.0	-2.0	-2.1	-1.7
Systolic Blood Pressure	1.0	4.9	7.8	0.3	-2.4	-2.8	-2.4
Average weekly fortified wine intake	1.0	1.2	2.5	-0.4	-1.2	-0.9	-1.6
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	4.2	-1.9	-2.0	-2.1	-1.6
Back pain experienced in last month	1.0	1.4	2.4	0.2	1.5	1.0	1.5
Impedance of whole body	1.0	5.3	8.1	-1.7	-2.9	-2.6	-1.9
Bipolar Disorder (2018)	0.9	1.5	1.7	0.9	1.3	1.3	1.3
Depression (Nagel 2018)	0.9	1.3	1.9	1.4	1.2	1.4	0.1
Respiratory disease	0.9	1.9	4.3	2.1	-0.8	-1.4	-0.9
Severe depression (siblings)	0.9	1.1	1.9	1.3	0.6	0.6	1.4
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	4.2	2.1	0.6	-0.2	0.6
Hair/balding pattern: Pattern 3	0.9	1.4	2.9	0.0	-1.7	-1.5	-0.7
Medication: Lansoprazole	0.9	1.0	3.2	-1.8	-0.5	-0.7	-0.3
Headache pain in last month	0.9	1.6	2.4	1.0	1.4	1.6	1.0
Angina (self-reported)	0.9	1.1	2.3	-0.6	-0.9	-1.5	-1.0
Medication: Gliclazide	0.9	1.0	1.6	-0.1	1.2	1.3	1.0
Financial situation satisfaction	0.9	1.1	1.8	-0.9	-1.0	-1.4	-0.8
Eye problems/disorders: Glaucoma	0.9	1.0	2.7	-0.8	-0.8	-0.3	-1.7
Medication: Paracetamol	0.9	1.5	5.6	2.4	-0.4	-0.2	0.1
Neuroticism (Nagel 2018)	0.8	1.9	2.5	1.4	1.6	1.6	0.7
Hypothyroidism (self reported)	0.8	1.8	3.1	-1.7	-1.1	-1.8	-0.2
Sensitivity / hurt feelings	0.8	1.4	4.9	2.2	0.5	0.6	0.4
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.2	1.5	1.2	0.9	0.2
Systolic blood pressure, automated reading	0.8	2.4	4.0	-0.3	-1.3	-2.0	-1.9
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.0	0.1	-1.2	-1.4	0.1
Forced vital capacity (FVC)	0.8	3.2	4.5	-2.1	-1.8	-1.8	-1.3
Allergy	0.8	1.8	6.1	-2.5	0.4	1.0	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	1.9	-0.4	-1.4	-1.3	-1.1
Falls in the last year	0.8	1.1	3.5	1.9	0.6	0.5	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.4	-0.2	-1.0	-1.5	-0.9
Chest pain or discomfort	0.8	1.2	2.6	-0.5	-1.2	-1.6	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.8	-0.5	1.4	1.2	0.7
Medication: Blood pressure	0.8	1.5	2.7	1.2	1.3	1.6	0.5
Depressed Affect (Nagel 2018)	0.7	1.5	2.4	1.6	1.4	1.1	0.8
Rheumatoid Arthritis	0.7	1.0	1.7	0.4	-0.9	-1.3	-1.2
Heel T-Score	0.7	5.2	8.3	0.8	-2.9	-2.8	-1.9
Relative age voice broke	0.7	1.1	1.3	1.0	0.9	1.1	1.1
Taking other prescription medications	0.7	1.0	2.5	-0.4	1.2	0.4	1.6
High blood pressure	0.7	2.0	3.2	1.5	1.3	1.8	1.1
Father’s age at death	0.7	0.9	1.9	-1.4	-0.6	-0.4	-1.1
Prospective memory result	0.7	0.9	1.1	-1.0	-0.9	-1.0	-0.7
Peak expiratory flow (PEF)	0.7	1.7	3.3	-0.4	-1.4	-1.8	-1.2
High blood pressure (siblings)	0.7	1.0	3.6	1.9	-0.2	-0.3	-0.3
Suffer from ‘nerves’	0.7	1.1	2.7	1.6	1.0	0.8	0.2
Overall health rating	0.7	1.4	2.5	-0.4	-1.3	-1.6	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.0	-1.2	-1.4	-0.9	-1.2
Qualifications: nursing, teaching	0.7	1.0	1.9	-1.4	-0.7	-0.9	-1.0
Ever smoked	0.7	1.3	1.7	-0.6	-1.3	-1.1	-1.3
Unable to work because of sickness or disability	0.7	0.9	1.6	0.7	-0.6	-1.0	-1.3
Alzheimer’s Disease (including proxy)	0.6	0.9	2.8	1.7	0.8	0.3	0.1
Coronary Artery Disease (CAD)	0.6	0.7	1.6	0.7	0.7	0.7	1.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.4	1.2	0.8	0.9	0.6
Medication for hormone replacement therapy	0.6	0.6	2.0	0.3	0.3	0.6	1.4
Qualifications: CSEs or equivalent	0.6	0.8	2.6	1.6	-0.3	-0.5	-0.4
Multivitamins +/- minerals	0.6	0.8	1.1	1.1	0.8	1.1	0.7
High blood pressure (mother)	0.6	0.8	1.4	-0.0	-1.0	-1.2	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.0	1.7	-0.6	-0.6	-0.1
Medication: Paracetamol	0.6	0.9	3.5	1.9	-0.3	0.1	0.4
Leg fat percentage (right)	0.6	2.1	3.4	0.6	-1.0	-1.8	-1.9
Mean time to correctly identify matches	0.6	1.1	3.5	1.9	-0.2	-0.6	-0.6
Comparative height size at age 10	0.6	3.0	4.6	-2.1	-1.8	-1.3	-1.6
Number of full sisters	0.6	0.7	2.8	1.7	-0.1	-0.3	0.2
Supplements: Vitamin C	0.6	0.7	1.3	-0.7	0.8	1.1	0.3
Hypertension (Self-reported)	0.6	1.7	2.8	1.4	1.1	1.7	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.0	1.4	0.5	0.0	-0.4
Eye problems/disorders: Cataract	0.6	0.7	1.0	0.7	1.0	0.9	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.0	-0.0	-1.3	-1.4	-1.0
Commuting to job workplace: Public transport	0.6	0.7	1.0	0.3	-1.0	-0.9	-0.9
High cholesterol (Self-reported)	0.6	1.1	3.8	2.0	0.4	0.5	0.4
Diastolic blood pressure, automated reading	0.6	2.0	3.4	1.8	1.4	1.3	1.0
Supplements: Calcium	0.6	0.7	1.4	1.2	-0.8	-0.5	-0.7
HDL Cholesterol	0.5	0.8	1.3	-0.4	1.2	0.6	1.2
Triglycerides	0.5	0.8	2.4	1.6	0.1	0.5	0.8
BMI	0.5	2.8	5.1	1.9	2.3	1.0	1.1
Medication: Co-codamol	0.5	0.6	0.9	-0.8	0.5	0.7	1.0
Qualifications: None of the above	0.5	1.0	1.8	-0.4	-1.4	-1.1	-1.0
Fluid intelligence score	0.5	1.0	1.6	1.1	0.7	0.8	1.2
Impedance of arm (right)	0.5	2.5	3.9	-2.0	-1.8	-1.3	-1.0
Medication: Cholesterol lowering	0.5	0.9	2.1	0.6	-0.8	-1.4	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.8	-0.8	-0.9	-0.7	-0.7
Had major operations	0.5	0.6	1.7	1.3	0.8	0.3	0.1
Mood swings	0.5	0.9	1.4	0.8	1.2	0.8	0.9
Loneliness, isolation	0.5	0.6	2.4	1.5	0.4	0.1	-0.2
Ever had bowel cancer screening	0.5	0.6	2.2	-1.5	0.2	0.3	0.2
Osteoporosis (self-reported)	0.5	0.6	1.4	-0.6	0.6	1.2	0.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.9	-1.4	0.2	0.0	0.7
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.4	-1.6	-0.8	-1.1	-1.0
Age at First Birth	0.4	0.6	1.3	1.1	-0.1	-0.9	-0.4
Crohns Disease (2012)	0.4	0.6	1.7	-1.3	-0.6	-0.5	-0.1
LDL Cholesterol	0.4	0.6	1.1	-0.4	0.6	1.0	1.0
Lupus	0.4	0.7	1.1	1.0	0.6	0.9	0.5
Cardiovascular Disease	0.4	1.3	2.2	1.5	0.9	1.2	0.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.9	0.9	0.7	0.4	0.2
Medication: Metformin	0.4	0.6	0.9	0.1	1.0	0.8	0.8
Trunk fat percentage	0.4	1.5	2.4	-0.8	-1.1	-1.5	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.0	0.8	0.7	1.0	0.2
Age when periods started (menarche)	0.4	1.0	1.6	1.0	0.7	0.9	1.2
Serious illness, injury or assault to yourself	0.4	0.5	1.4	-1.2	0.3	-0.6	-0.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.9	1.4	-0.1	-0.9	0.6
Stomach or abdominal pain in last month	0.4	0.5	1.2	0.5	0.5	0.4	1.1
Illnesses of siblings	0.4	0.6	2.4	-1.6	-0.2	0.1	-0.3
Impedance of arm (left)	0.4	1.7	2.6	-1.6	-1.5	-1.2	-0.6
Length of working week for main job	0.4	0.4	0.8	-0.0	-0.4	-0.9	-0.9
Exposure to tobacco smoke at home	0.4	0.4	0.7	0.8	-0.3	-0.8	-0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.2	-1.5	-0.5	-1.0	0.3
Medication: Amlodipine	0.4	0.5	1.2	-1.1	-0.7	-0.3	-0.4
Body fat percentage	0.4	1.7	2.9	-0.4	-1.1	-1.7	-1.6
Migraine (self-reported)	0.4	0.5	1.0	0.2	0.9	1.0	0.3
Medication: Seretide 50 evohaler	0.4	0.5	1.6	0.4	0.4	-0.2	-1.3
Medication: Aspirin	0.4	0.5	0.8	0.7	-0.8	-0.9	-0.2
Knee pain experienced in last month	0.4	0.7	2.5	-1.6	-0.5	-0.1	0.1
Illnesses of father: Heart disease	0.4	0.6	1.5	0.3	0.8	0.3	1.2
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.1	1.1	0.3	-0.3	-0.6
Long-standing illness, disability or infirmity	0.4	0.7	1.2	-0.9	-0.6	-1.1	-0.4
Medication for cholesterol	0.4	0.6	0.9	-0.9	-0.5	-1.0	-0.6
Average weekly champagne plus white wine intake	0.4	0.6	1.8	-1.3	0.0	0.7	0.2
Leg fat percentage (left)	0.4	1.6	3.0	0.7	-0.7	-1.6	-1.7
Bipolar Disorder or Schizophrenia	0.3	0.7	1.0	1.0	0.9	1.0	0.4
Major Depression (MDD)	0.3	0.4	1.3	1.2	-0.1	-0.3	0.4
Body Mass Index (BMI) (2010)	0.3	0.4	0.5	-0.7	-0.7	-0.7	-0.5
Fasting Glucose	0.3	0.4	0.9	-0.0	-0.6	-0.4	-0.9
Primary Biliary Cirrhosis	0.3	0.5	1.3	0.1	1.2	0.2	0.7
Height	0.3	5.8	15.5	-3.9	-2.2	-1.2	-1.2
Allergy or Eczema	0.3	0.9	1.8	1.4	0.4	-0.3	1.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.4	-0.1	-0.8	-0.6	-1.2
Lung FVC	0.3	1.8	2.3	-1.5	-1.3	-1.3	-1.1
Supplements: Zinc	0.3	0.3	1.1	1.0	0.1	-0.3	0.4
Fed-up feelings	0.3	0.5	1.0	1.0	0.4	0.2	0.8
Medication: Levothyroxine sodium	0.3	0.5	0.9	-0.9	-0.5	-0.9	-0.1
Trunk fat mass	0.3	1.3	1.9	-0.7	-0.9	-1.4	-1.4
Nervous feelings	0.3	0.5	1.0	-0.1	-0.7	-0.7	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	0.7	-0.4	-0.7	-1.0
Had other major operations	0.3	0.3	1.1	-1.1	0.2	0.0	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	0.9	0.8	-1.0	-0.9	-0.7
Worrier / anxious feelings	0.3	0.6	2.2	-1.5	-0.3	0.0	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.4	0.8	0.8	0.5	0.3	-0.9
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.5	0.2	-0.7	-0.7	-0.4
Loud music exposure frequency	0.3	0.4	0.6	0.4	-0.8	-0.6	-0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.8	0.7	0.8	0.9	0.2
Glaucoma (self-reported)	0.3	0.4	1.2	1.1	0.2	0.4	-0.4
Birth weight	0.3	0.7	1.8	0.5	1.4	0.9	-0.3
Health satisfaction	0.3	0.4	1.6	1.3	0.3	-0.2	-0.1
Neck or shoulder pain in last month	0.3	0.4	0.9	-0.0	-0.4	-0.9	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.5	1.2	-0.2	-0.2	-0.1
Leg fat-free mass (right)	0.3	1.4	2.4	-0.4	1.5	1.5	1.0
Medication: Aspirin	0.3	0.4	1.2	1.1	-0.4	-0.5	-0.2
Leg predicted mass (right)	0.3	1.4	2.3	-0.3	1.5	1.5	1.0
Miserableness	0.3	0.5	1.2	1.1	0.8	0.5	0.2
Guilty feelings	0.3	0.5	0.7	-0.6	0.8	0.8	0.6
Medication: Atorvastatin	0.3	0.3	0.5	-0.0	-0.7	-0.7	-0.6
Average weekly beer plus cider intake	0.3	0.5	1.3	-0.2	-0.7	-1.1	0.1
Myopia	0.3	0.5	0.8	0.2	-0.7	-0.9	-0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.9	0.3	-0.4	-1.0	-0.4
Heart disease (siblings)	0.3	0.4	0.6	0.5	0.1	-0.7	-0.8
Crohns Disease (2017)	0.2	0.5	1.1	0.5	-1.1	-0.4	-0.7
Schizophrenia (2014)	0.2	0.3	0.6	0.3	0.8	0.8	0.2
Ulcerative Colitis	0.2	0.3	1.0	-0.1	-0.2	0.2	1.0
Waist Hip Ratio (WHR)	0.2	0.8	2.0	-1.1	-1.4	-0.2	0.1
Neuroticism	0.2	0.4	1.3	1.1	0.1	0.1	-0.6
Hair Pigment	0.2	5.9	9.7	-0.3	-2.5	-3.1	-2.7
Number of treatments/medications taken	0.2	0.4	1.0	1.0	-0.7	-0.5	-0.1
Relative age of first facial hair	0.2	0.4	0.9	-0.9	-0.3	0.1	0.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	0.3	-0.6	-0.8	-0.2
Leg fat-free mass (left)	0.2	1.2	2.0	-0.1	1.4	1.4	0.9
Sitting height	0.2	1.6	2.6	-1.3	0.7	1.6	1.2
Leg predicted mass (left)	0.2	1.2	1.9	-0.2	1.4	1.4	0.9
Heart attack	0.2	0.3	0.9	0.1	-0.4	-0.9	-0.3
Medication: Simvastatin	0.2	0.3	0.9	0.2	-0.4	-1.0	-0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.7	-0.2	0.8	0.8	0.1
Standing height	0.2	1.7	5.0	-2.2	-1.2	-0.4	-0.6
Breastfed as a baby	0.2	0.3	0.8	-0.4	0.9	0.4	-0.1
Tense / ‘highly strung’	0.2	0.3	0.9	-1.0	-0.2	-0.2	-0.3
Pulse wave reflection index	0.2	0.2	0.7	-0.2	-0.9	-0.2	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	0.5	0.7	0.9	0.2
Gout (self-reported)	0.2	0.2	0.5	-0.6	-0.0	0.7	-0.1
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	-0.3	0.1	0.1	0.8
Exposure to tobacco smoke outside home	0.2	0.2	0.8	0.9	0.2	-0.0	0.2
Number of full brothers	0.2	0.2	0.7	-0.8	-0.3	-0.3	-0.0
Worry too long after embarrassment	0.2	0.3	1.0	1.0	0.1	0.3	0.5
Shortness of breath walking on level ground	0.2	0.3	1.0	1.0	-0.1	-0.0	0.2
Eye problems/disorders: None of the above	0.2	0.3	0.9	-0.9	0.1	0.1	0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	0.8	-0.0	-0.2	0.7
Medication: Allopurinol	0.2	0.2	0.5	-0.3	0.2	0.7	-0.5
Heart disease (mother)	0.2	0.2	0.6	0.8	-0.1	-0.3	0.2
Whole body fat mass	0.2	0.7	1.2	-0.2	-0.5	-1.1	-1.1
Leg fat mass (right)	0.2	0.9	1.9	0.4	-0.6	-1.2	-1.4
Average weekly red wine intake	0.2	0.3	0.8	0.9	0.2	0.2	-0.4
Diabetes diagnosed by doctor	0.2	0.3	0.5	0.1	-0.5	-0.7	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.9	-0.2	-0.2	-0.4	-0.9
Mineral and other dietary supplements	0.2	0.2	0.5	-0.7	-0.1	-0.6	-0.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.7	0.4	0.2	0.4
Illnesses of father: High blood pressure	0.2	0.3	0.9	-0.9	-0.4	0.1	-0.4
Number of operations (self-reported)	0.2	0.3	0.6	-0.6	-0.1	-0.4	-0.8
Age started oral contraceptive pill	0.2	0.2	0.9	-0.9	0.2	0.1	0.0
Commuting to job workplace: Cycle	0.2	0.2	0.7	-0.8	-0.1	-0.3	-0.4
Cholesterol lowering medication	0.2	0.4	1.1	1.1	0.4	-0.1	-0.3
Leg fat mass (left)	0.2	0.7	1.6	0.3	-0.4	-1.0	-1.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.5	0.3	0.6	0.6	0.7
Schizophrenia (2018)	0.1	0.2	0.3	0.6	0.1	0.2	-0.5
Worry (Nagel 2018)	0.1	0.2	0.4	0.4	0.2	0.2	-0.6
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.1	0.4	0.3	-0.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	0.7	-0.7	-0.2	-0.2
Ulcerative Colitis (UC)	0.1	0.2	0.7	0.8	-0.1	0.1	0.1
Mean Putamen Volume	0.1	0.1	0.2	-0.2	0.3	0.4	0.0
HbA1C	0.1	0.1	0.3	-0.0	0.3	0.5	-0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.4	0.0	-0.2	-0.4
Blood White Count	0.1	1.0	2.7	1.6	0.7	0.8	0.2
Smoking Status	0.1	0.1	0.2	-0.4	-0.4	0.5	-0.2
Lung FEV1/FVC ratio	0.1	0.3	0.7	-0.3	0.8	0.6	0.5
Chronotype (morning person)	0.1	0.2	0.4	-0.5	0.1	-0.6	-0.6
Tanning	0.1	1.5	2.7	-0.5	1.6	1.2	1.3
Average weekly spirits intake	0.1	0.1	0.2	-0.3	-0.1	0.4	0.5
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.0	-0.5	-0.1	-0.5
Vitamin and mineral supplements	0.1	0.2	0.3	-0.1	-0.5	-0.6	-0.4
Pack years adult smoking proportion	0.1	0.1	0.2	0.5	-0.4	-0.1	0.2
Maternal smoking around birth	0.1	0.2	0.6	0.2	0.0	0.8	0.4
Medication: Atenolol	0.1	0.1	0.2	-0.5	0.1	0.2	-0.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	0.1	0.2	0.3	0.5
Body mass index (BMI)	0.1	0.4	0.9	0.8	1.0	0.1	0.2
Number of incorrect matches in round	0.1	0.1	0.2	0.5	0.3	-0.3	-0.0
Past tobacco smoking	0.1	0.2	0.8	-0.4	0.2	0.1	0.9
Alcohol usually taken with meals	0.1	0.2	0.3	-0.4	0.6	0.3	0.4
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.5	0.2	0.6	0.2
Had menopause	0.1	0.2	0.3	-0.5	-0.5	-0.1	-0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	0.6	-0.4	-0.3	0.3
Diabetes (self-reported)	0.1	0.2	0.3	-0.5	-0.4	-0.4	-0.5
Medication: Ramipril	0.1	0.1	0.4	-0.6	0.1	-0.1	0.3
Neuroticism score	0.1	0.2	0.4	0.6	-0.0	-0.2	-0.6
Arm fat percentage (right)	0.1	0.5	0.9	0.5	-0.2	-1.0	-0.9
Hip circumference	0.1	0.4	0.8	0.8	0.9	-0.0	-0.3
Number of live births	0.1	0.1	0.3	-0.1	-0.1	-0.5	0.5
Happiness	0.1	0.1	0.3	-0.3	-0.5	-0.5	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.5	0.3	0.3	-0.1
Illnesses of mother	0.1	0.1	0.4	-0.3	0.2	0.6	0.0
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	-0.5	-0.0	-0.0	-1.0
Blood clot in the leg (DVT)	0.1	0.1	0.3	-0.5	-0.3	-0.1	-0.0
Comparative body size at age 10	0.1	0.3	1.0	-0.0	1.0	-0.3	0.3
Age at first live birth	0.1	0.3	0.7	-0.3	-0.5	-0.8	-0.3
Qualifications: College or University degree	0.1	0.3	1.2	-0.2	0.2	0.2	1.1
Medication: Blood pressure	0.1	0.2	0.8	-0.9	-0.0	0.2	0.1
Alcohol intake frequency.	0.1	0.2	0.7	-0.2	-0.4	-0.3	-0.8
Whole body fat-free mass	0.1	0.4	0.8	-0.1	0.9	0.9	0.4
Arm fat percentage (left)	0.1	0.5	1.1	0.2	-0.3	-1.1	-0.8
Friendships satisfaction	0.1	0.1	0.2	0.3	0.2	-0.4	0.5
Whole body water mass	0.1	0.4	0.8	-0.0	0.8	0.9	0.5
Wears glasses or contact lenses	0.1	0.1	0.2	0.0	-0.2	-0.4	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.6	0.2	0.3	-0.2
Alcohol drinker status: Never	0.1	0.1	0.2	-0.2	-0.0	0.1	-0.5
Risk taking	0.1	0.1	0.4	0.2	0.6	0.2	-0.1
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.5	0.2	0.7	0.2	-0.1
Ever depressed for a whole week	0.1	0.2	0.5	-0.4	0.1	0.0	0.7
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.1	-0.3	-0.0	0.3	0.4
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.3	-0.2	0.2	-0.1	-0.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.0	0.2	0.7	-0.3	0.2	-0.2	-0.8
Current tobacco smoking	0.0	0.1	0.1	-0.3	-0.3	0.3	0.2
Waist circumference	0.0	0.1	0.1	0.3	0.0	-0.2	-0.4
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	0.0	-0.1	0.2	0.1
Weight	0.0	0.0	0.1	-0.2	0.4	-0.0	-0.2
Trunk fat-free mass	0.0	0.1	0.3	-0.0	0.5	0.5	-0.0
Time employed in main current job	0.0	0.1	0.2	0.4	-0.2	-0.1	0.1
Arm fat mass (right)	0.0	0.2	0.4	0.2	0.0	-0.6	-0.5
Trunk predicted mass	0.0	0.1	0.2	0.1	0.4	0.4	-0.0
Arm fat-free mass (right)	0.0	0.1	0.3	-0.1	0.5	0.4	0.4
Wheeze or whistling in the chest in last year	0.0	0.1	0.2	0.1	-0.1	-0.3	-0.4
Arm predicted mass (right)	0.0	0.1	0.2	0.1	0.4	0.5	0.1
Smoking status: Previous	0.0	0.1	0.2	0.3	0.0	0.2	-0.4
Smoking status: Current	0.0	0.1	0.1	0.3	-0.2	0.4	0.1
Arm fat mass (left)	0.0	0.2	0.4	0.2	0.0	-0.7	-0.5
Medication: Lisinopril	0.0	0.0	0.1	0.0	0.0	0.0	-0.3
Basal metabolic rate	0.0	0.3	0.5	-0.1	0.7	0.7	0.3
Arm fat-free mass (left)	0.0	0.1	0.1	0.0	0.4	0.3	-0.2
Pack years of smoking	0.0	0.1	0.2	0.4	-0.2	-0.0	0.3
Arm predicted mass (left)	0.0	0.0	0.0	0.1	0.2	0.0	-0.2

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Trait associations