Hub : Genes

GSTA4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1330	0.0450	1.6e-03	-0.001	NA	0.017	NA	0.002	4.1e-01	NA	1.9e-02	NA	2.0e-01
2	GTEx	Colon Transverse	0.1960	0.0830	9.9e-03	0.017	NA	0.001	NA	0.001	5.0e-02	NA	2.8e-01	NA	2.9e-01
3	GTEx	Esophagus Mucosa	0.1380	0.0480	1.4e-03	0.081	NA	0.059	NA	0.072	4.2e-06	NA	8.4e-05	NA	1.5e-05
4	METSIM	Adipose	0.0673	0.0213	2.3e-05	0.005	0.021	0.024	0.022	0.021	4.4e-02	0.00036	1.2e-04	0.00022	2.9e-04
5	YFS	Blood	0.0195	0.0073	8.0e-04	0.005	0.011	0.009	0.011	0.005	6.1e-03	0.00010	4.2e-04	0.00012	5.6e-03
6	TCGA	Brain Lower Grade Glioma	0.0462	0.0253	7.5e-03	0.021	0.010	0.010	NA	0.011	1.8e-03	0.02500	2.1e-02	NA	1.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.3	2.0	4.7	2.2	2.1	0.2	0.9	-1.1	0.8
Bipolar Disorder or Schizophrenia	0.5	1.3	5.0	2.2	1.2	-0.1	0.1	-0.9	0.5
Depressed Affect (Nagel 2018)	1.0	2.1	3.3	0.3	1.7	1.8	-1.5	-1.6	-1.0
Depression (Nagel 2018)	0.5	0.7	2.1	0.2	-0.1	0.7	-1.4	-1.3	-0.1
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.8	-1.6	-0.3	-0.2	-0.4	-2.0	-0.1
Neuroticism (Nagel 2018)	0.6	1.5	3.5	0.3	1.3	1.5	-1.9	-0.9	-0.6
Schizophrenia (2018)	0.1	0.3	1.1	1.1	-0.1	-0.3	-0.5	-0.3	-0.0
Schizophrenia vs Biploar Disorder	0.8	1.1	3.6	-0.7	-1.9	-0.6	0.1	1.1	-0.9
Worry (Nagel 2018)	0.3	0.7	2.4	0.7	-0.1	0.8	-0.0	1.6	0.8
Alzheimer’s Disease (in mother)	0.2	0.2	0.8	0.4	-0.9	0.3	0.3	0.3	-0.4
Alzheimer’s Disease (in father)	1.5	1.6	3.5	-0.8	0.5	1.1	1.5	1.9	1.3
Alzheimer’s Disease (including proxy)	0.3	0.4	1.4	-0.0	-0.4	0.4	1.2	0.5	0.7
Crohns Disease (2017)	0.3	0.6	1.9	-0.5	0.0	-1.3	-0.0	-1.4	-0.4
Irritable Bowel Disease (IBD)	0.3	0.8	2.7	-0.2	0.8	-0.0	0.7	0.8	1.6
Ulcerative Colitis (UC)	1.5	2.9	7.3	0.3	1.4	1.2	1.5	2.1	2.7
Major Depression (MDD)	1.5	1.8	3.9	-1.2	-1.7	0.0	0.8	2.0	1.2
Reaction Time	0.3	0.5	1.6	1.3	-0.1	-0.1	-0.5	-0.7	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.7	-0.6	-0.5	0.1	1.3	-0.9	0.5
Breast Cancer	0.4	1.0	3.9	0.6	2.0	-0.3	-1.1	0.3	0.2
Ovarian Cancer	0.2	0.3	1.0	0.4	0.1	-0.9	-1.0	-0.1	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.6	2.3	8.1	-0.1	-1.2	0.2	1.4	2.8	1.5
Bipolar Disorder (2011)	1.0	1.0	2.5	1.0	0.0	1.6	0.7	-0.9	1.1
Body Mass Index (BMI) (2010)	1.3	1.8	4.3	-1.5	-0.2	-1.4	-2.1	-1.3	-0.7
Coronary Artery Disease (CAD)	1.2	1.5	2.6	0.4	1.4	0.2	-1.3	-1.6	1.6
Crohns Disease (2012)	0.6	1.0	3.8	0.9	0.3	-0.7	-0.9	-1.9	-0.3
Mean Putamen Volume	1.6	1.8	5.2	-1.0	0.9	-0.4	1.9	-0.1	2.3
Fasting Glucose	0.5	0.7	1.0	-0.7	-0.3	-1.0	0.8	1.0	-0.8
HbA1C	0.2	0.2	0.3	-0.5	0.4	0.4	-0.3	-0.3	-0.5
HDL Cholesterol	1.5	2.6	9.6	0.9	-1.4	0.9	1.4	3.1	0.7
LDL Cholesterol	0.6	0.9	2.4	0.6	1.3	0.0	-0.9	-1.5	0.3
Lupus	1.2	1.9	3.7	1.3	0.8	1.2	1.9	1.2	1.6
Neuroticism (2016)	0.1	0.2	0.4	0.2	-0.4	0.5	-0.6	0.4	-0.1
Primary Biliary Cirrhosis	0.9	1.3	4.1	-1.0	-0.0	0.5	2.0	1.5	0.4
Rheumatoid Arthritis	0.3	0.5	1.5	0.7	-1.2	-0.1	0.1	-0.9	0.1
Schizophrenia (2014)	0.1	0.3	1.2	1.1	-0.3	-0.6	-0.1	-0.3	-0.2
Triglycerides	0.8	1.3	3.5	-1.1	0.5	-1.1	-0.1	-1.9	-1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.8	0.7	-0.2	1.2	-0.1	0.4	-1.4
Ulcerative Colitis	1.0	1.5	4.6	0.8	1.4	2.1	-0.0	1.3	0.5
Blood Eosinophil Count	0.3	2.1	6.9	1.2	0.8	0.4	-1.3	-1.4	-2.6
Blood Platelet Count	0.9	10.1	46.9	3.0	1.2	-1.7	-0.4	-6.8	0.6
Blood Red Count	0.4	3.8	7.3	2.3	-0.4	2.4	1.0	2.7	1.8
Blood White Count	0.2	1.1	2.8	1.5	-0.3	0.3	1.7	-0.5	-1.2
Heel T-Score	0.3	2.4	7.4	-0.1	-0.6	-2.4	2.7	1.1	-0.1
BMI	0.7	4.0	10.3	-0.4	-0.2	0.3	-2.7	-3.2	-2.5
Height	0.2	4.2	21.7	-0.7	0.4	1.2	-0.5	1.0	4.7
Waist Hip Ratio (WHR)	0.3	1.2	4.0	-0.6	-1.3	-0.8	-0.8	0.1	-2.0
Systolic Blood Pressure	0.4	2.2	4.8	-0.9	-2.1	-1.4	0.9	2.2	-0.7
Smoking Status	2.9	7.0	22.7	-0.4	0.0	-0.1	-2.5	-3.6	-4.8
Allergy or Eczema	0.4	1.0	3.7	-0.0	0.7	-0.1	1.9	1.1	0.6
Cardiovascular Disease	0.1	0.4	1.6	-0.7	-0.5	-0.0	-0.4	0.1	-1.3
Hypothyroidism (self reported)	0.3	0.8	1.8	0.6	-0.3	0.3	-1.1	-1.0	-1.3
Respiratory disease	0.5	1.1	2.7	-1.6	-1.2	-0.2	-0.7	-0.9	-1.2
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.1	-0.7	-0.6	-1.0	0.6	0.7	-0.7
Lung FEV1/FVC ratio	0.8	4.0	10.3	0.6	-1.3	1.8	2.1	3.2	1.9
Lung FVC	0.6	3.1	6.9	1.6	1.4	-2.6	-0.0	-1.4	2.4
Neuroticism	0.3	0.7	2.2	-0.3	-0.7	1.5	-0.9	0.9	-0.2
Chronotype (morning person)	0.2	0.5	1.0	0.7	0.8	-0.6	1.0	0.2	-0.4
Hair Pigment	0.1	1.4	4.0	-0.0	0.5	-2.0	0.7	1.9	0.4
Tanning	0.0	0.5	1.2	0.6	-0.0	-0.5	-0.2	-1.1	-0.9
Hand grip strength (left)	0.4	1.0	2.1	-0.7	-0.3	0.9	1.0	1.2	1.4
Number of treatments/medications taken	0.3	0.5	1.0	0.5	1.0	0.4	-0.4	-0.8	-1.0
Average weekly spirits intake	0.5	0.6	2.1	-0.7	0.7	0.4	1.5	0.1	0.7
Sensitivity / hurt feelings	0.3	0.6	2.7	-0.3	-0.5	0.6	-1.6	0.2	-0.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	0.6	0.1	0.5	-1.1	-0.6	0.3
Hearing difficulty/problems: Yes	0.4	0.6	1.5	-1.2	-0.8	0.4	0.8	0.8	-0.1
Relative age of first facial hair	0.9	1.8	6.5	-0.0	0.2	-0.4	1.7	0.9	2.5
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	4.1	0.2	2.0	0.8	-1.8	-1.0	-2.0
Ever used hormone-replacement therapy (HRT)	1.1	1.4	6.9	0.2	0.1	-2.6	0.0	0.2	1.1
Ever had hysterectomy (womb removed)	0.9	1.0	2.3	-1.1	-0.3	-1.3	0.5	-0.4	-1.5
Systolic blood pressure, automated reading	0.6	1.7	4.4	-1.5	-1.3	-0.7	1.0	2.1	-0.4
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.2	0.9	0.9	1.1	1.5	0.8	0.5
Angina	1.4	1.8	4.3	1.6	1.8	0.6	-2.1	-0.5	-0.3
Medication for hormone replacement therapy	0.5	0.5	1.6	0.6	0.6	-0.9	-0.0	-0.0	-1.3
Vitamin and mineral supplements	0.6	0.8	2.2	-0.8	0.3	0.5	-0.3	-1.5	-1.3
Supplements: Zinc	1.9	2.1	5.3	-0.7	0.6	0.4	2.3	2.3	1.1
Medication: Co-codamol	1.7	1.9	5.7	-0.6	-0.5	-1.2	-0.5	-1.8	-2.4
Medication: Metformin	1.0	1.4	2.4	1.2	0.7	0.0	1.5	1.3	1.5
Diabetes (father)	1.8	2.2	10.9	1.3	3.3	-0.0	0.5	-0.6	0.3
Diabetes (mother)	0.8	1.1	2.5	0.9	-0.9	0.6	1.3	-0.4	1.6
Severe depression (siblings)	0.8	0.9	2.2	-1.0	-0.8	0.1	1.5	1.1	0.6
Pack years adult smoking proportion	1.8	2.7	7.1	1.3	0.8	0.9	-0.4	-2.4	-2.7
Impedance of leg (right)	0.4	2.1	4.9	1.5	-1.8	-0.2	1.5	2.2	0.2
Leg fat-free mass (left)	0.4	2.4	3.8	-1.9	1.4	1.2	-1.7	-2.0	0.5
Trunk fat percentage	0.3	1.0	2.2	0.2	0.7	0.9	-1.5	-1.5	-0.5
Hand grip strength (right)	0.7	1.9	3.9	-0.9	-1.0	1.2	2.0	1.8	1.1
Townsend deprivation index at recruitment	1.8	2.5	4.7	0.8	1.7	0.1	-1.9	-2.2	-1.7
Current tobacco smoking	3.0	4.8	16.4	0.8	-0.0	1.0	-1.7	-2.8	-4.0
Average weekly fortified wine intake	0.6	0.8	2.9	-0.3	-1.7	1.0	-0.1	0.2	-0.7
Maternal smoking around birth	2.0	2.9	6.6	0.9	1.2	-1.1	-2.4	-1.2	-2.6
Fed-up feelings	0.6	1.1	2.6	0.0	0.9	1.2	-1.3	-1.6	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	4.4	2.1	0.7	1.1	-0.9	-1.3	0.4
Relative age voice broke	4.7	7.2	16.9	0.0	-1.1	0.9	4.1	3.0	3.9
Taking other prescription medications	0.5	0.8	2.2	0.7	1.5	0.7	-1.3	-0.2	0.1
Age when periods started (menarche)	2.3	5.5	18.5	2.7	2.3	0.9	-0.2	1.0	4.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	-1.2	-0.9	-1.1	0.5	0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.6	0.1	0.7	-0.9	0.8	1.6	0.6
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.9	0.1	-0.4	-1.7	0.6	-0.7	-0.6
Qualifications: CSEs or equivalent	1.2	1.6	4.2	1.2	0.9	-0.8	-1.2	-2.1	-1.0
Serious illness, injury or assault to yourself	0.3	0.4	1.7	0.5	0.3	-0.4	-0.2	-1.3	-0.0
High blood pressure	0.1	0.2	0.7	-0.6	0.0	-0.1	0.2	0.8	-0.3
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.7	0.8	0.6	0.2	1.9	1.3	1.2
Multivitamins +/- minerals	0.5	0.7	2.7	0.6	0.8	-0.6	0.1	0.3	1.6
Stomach or abdominal pain in last month	0.6	0.8	2.6	1.0	0.3	0.7	-1.6	-0.7	-0.1
Supplements: Glucosamine	1.4	1.8	4.5	1.0	-0.4	-0.7	1.4	1.8	2.1
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	5.9	-0.3	0.6	-2.4	-1.5	-1.6	-0.7
Medication: Atenolol	1.8	2.3	7.3	0.7	1.1	-0.2	-2.7	-0.5	-2.1
Medication: Levothyroxine sodium	0.7	1.2	2.6	0.3	-0.6	0.8	-1.6	-1.1	-1.6
Sitting height	0.2	1.5	4.2	-2.0	-0.3	0.1	0.8	-1.0	1.7
Chronic bronchitis/emphysema (father)	2.8	3.2	10.9	-1.3	-0.6	1.2	-2.1	-0.5	-3.3
High blood pressure (mother)	1.0	1.4	2.9	0.1	-0.4	1.6	1.2	1.7	1.2
Body mass index (BMI)	0.6	2.5	5.8	-0.1	1.4	0.9	-2.3	-2.4	-1.0
Impedance of leg (left)	0.5	2.3	3.7	1.8	-1.6	-0.8	1.8	1.9	0.6
Leg predicted mass (left)	0.5	2.4	3.8	-1.9	1.5	1.3	-1.7	-1.9	0.5
Trunk fat mass	0.3	1.4	3.3	-0.2	1.0	1.0	-1.8	-1.8	-0.2
Waist circumference	0.5	1.9	5.6	-0.7	0.7	-0.2	-1.9	-2.4	-1.1
Number of incorrect matches in round	0.4	0.7	2.5	0.6	-0.8	-0.2	-0.7	1.6	-0.5
Past tobacco smoking	2.6	4.7	15.4	0.6	-0.3	0.1	1.6	3.2	3.9
Alcohol usually taken with meals	2.0	3.2	11.3	1.0	1.0	0.5	1.4	1.9	3.4
Nervous feelings	0.7	1.3	3.7	1.4	-0.3	-0.1	-0.1	1.4	1.9
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	4.3	0.0	0.9	1.8	-1.9	-2.1	-1.1
Hearing difficulty/problems with background noise	1.0	1.6	2.8	-1.6	-1.7	1.1	0.1	1.2	1.3
Hair/balding pattern: Pattern 2	1.0	1.3	2.9	0.1	0.1	-1.0	1.7	1.5	1.3
Had menopause	0.4	0.5	1.1	-0.6	-0.3	-1.0	-1.1	0.6	0.2
Had other major operations	0.6	0.8	2.7	0.1	-0.4	1.1	-1.7	-0.6	-0.0
Forced vital capacity (FVC)	1.1	4.1	19.6	0.5	1.7	-0.2	1.4	0.1	4.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.7	0.2	0.8	-0.7	0.8	1.6	0.8
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	4.0	1.4	2.0	0.7	-1.5	-1.4	0.2
Qualifications: None of the above	1.3	2.7	9.2	0.3	0.4	-0.6	-3.0	-2.0	-1.6
Financial difficulties in last 2 years	0.9	1.2	3.9	-0.0	0.7	1.6	-0.1	-0.5	-2.0
Mouth/teeth dental problems	0.3	0.4	1.0	0.4	0.9	0.5	-0.6	0.0	1.0
Heart attack	0.5	0.6	1.5	1.2	0.5	-0.4	-0.7	-0.3	-1.0
Allergy	0.1	0.3	0.7	-0.3	-0.8	-0.4	-0.5	0.4	0.8
Pain all over the body in last month	1.5	1.6	3.2	-1.1	0.8	-0.4	-1.8	-1.7	-1.1
Diabetes (self-reported)	0.1	0.1	0.2	0.5	0.4	-0.1	0.2	0.3	-0.4
Hayfever/allergic rhinitis (self-reported)	2.1	2.7	6.4	-0.2	-0.4	-0.2	2.5	2.0	2.4
Medication: Ramipril	0.3	0.4	0.7	0.5	0.8	0.4	-0.2	-0.7	-0.7
Medication: Simvastatin	1.9	2.8	10.2	0.7	-0.3	1.3	-1.7	-1.3	-3.2
Fluid intelligence score	0.5	1.0	3.7	-0.3	-0.3	0.7	1.3	0.2	1.9
Illnesses of siblings	0.3	0.5	1.3	-0.8	0.2	0.7	-1.1	-0.5	-0.4
Neuroticism score	0.3	0.6	1.3	1.0	0.7	1.1	-1.0	0.0	-0.2
Weight	0.3	1.5	2.9	-1.1	1.0	1.0	-1.7	-1.7	0.4
Impedance of arm (right)	0.3	1.2	4.6	0.0	-2.1	-0.5	1.1	1.1	-0.1
Arm fat percentage (right)	0.5	1.8	4.0	-0.1	0.5	1.0	-2.0	-2.0	-1.3
Trunk fat-free mass	0.3	1.6	5.3	-2.3	0.6	0.9	-1.4	-1.0	0.5
Hip circumference	0.3	1.2	3.6	-1.1	1.2	0.4	-0.6	-1.9	0.4
Time employed in main current job	1.2	1.4	3.1	-0.7	-1.4	-0.2	1.7	0.4	1.8
Alcohol intake versus 10 years previously	2.9	4.4	8.4	1.7	-0.6	1.8	-2.8	-1.9	-2.9
Father’s age at death	1.2	1.6	5.8	-0.5	-0.7	-2.4	0.3	1.3	1.0
Worrier / anxious feelings	1.3	2.5	6.5	2.6	2.1	1.0	-1.4	-0.9	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	3.3	0.2	1.6	1.6	-1.8	-1.4	-0.4
Falls in the last year	1.4	1.9	4.4	-0.9	-2.1	-0.0	-1.8	-0.5	-1.7
Hair/balding pattern: Pattern 3	0.6	0.9	1.7	-0.6	-1.0	-0.9	-0.9	-1.3	-0.8
Number of live births	0.9	1.3	2.8	0.2	1.4	0.9	-1.1	-1.7	-0.9
Forced expiratory volume in 1-second (FEV1)	1.7	5.7	25.3	0.7	1.2	0.5	2.2	1.1	5.0
Pulse rate	0.4	0.7	2.5	-0.1	-1.6	-0.5	-0.3	0.4	-1.1
Happiness	0.7	0.9	2.3	-1.2	-0.1	-0.4	-0.9	-0.7	-1.5
Noisy workplace	1.7	2.1	6.4	0.2	-0.6	0.3	-2.2	-0.9	-2.5
Qualifications: A levels/AS levels or equivalent	0.7	1.6	3.7	-1.8	-1.1	-0.3	1.9	0.6	1.2
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	8.4	-0.7	0.5	2.9	1.4	1.4	1.0
Mouth/teeth dental problems: Dentures	0.7	1.2	3.5	-0.0	0.2	0.2	-0.7	-1.9	-1.8
Asthma	0.8	1.7	5.5	-1.1	-1.0	0.0	-0.8	-1.3	-2.3
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	3.5	0.2	0.2	1.9	-1.1	-1.2	-1.0
Medication: Cholesterol lowering	0.5	0.8	3.7	0.8	-0.1	0.3	-0.6	-0.3	-1.9
Depression (self-reported)	1.1	1.3	4.9	-0.6	0.7	2.2	-0.1	1.4	-0.1
Medication: Lansoprazole	0.7	0.8	2.3	-0.8	1.0	-1.5	-0.8	-0.4	-0.6
Prospective memory result	1.7	2.1	5.6	-1.9	-1.0	0.6	-1.4	0.6	-2.4
Lung cancer (father)	2.2	2.6	5.8	1.4	2.4	2.4	-0.6	-1.4	-0.1
Illnesses of mother	0.3	0.4	1.5	0.2	1.2	-0.5	-0.8	0.0	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.6	22.6	0.5	0.7	0.4	2.8	1.6	4.8
Pulse wave Arterial Stiffness index	1.9	2.2	4.7	-1.5	0.7	-1.5	-1.5	-2.2	-1.3
Impedance of arm (left)	0.2	1.1	3.0	0.0	-1.1	-0.3	1.5	1.7	0.6
Arm fat mass (right)	0.4	1.7	3.7	-0.4	1.2	1.0	-1.9	-1.9	-0.5
Trunk predicted mass	0.3	1.7	5.6	-2.4	0.6	0.9	-1.4	-1.0	0.5
Standing height	0.3	2.8	8.9	-2.4	-0.5	0.4	0.8	1.2	3.0
Length of working week for main job	0.4	0.4	1.0	-0.8	1.0	-0.8	-0.2	-0.2	0.1
Exposure to tobacco smoke at home	0.4	0.5	1.5	0.2	-0.6	-0.1	1.0	0.3	-1.2
Breastfed as a baby	0.3	0.3	0.7	-0.5	-0.2	-0.7	0.9	0.5	0.3
Tense / ‘highly strung’	0.6	1.0	2.5	1.1	0.2	-0.5	0.4	1.6	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.7	-1.1	-0.7	1.3	-0.4	0.4	0.6
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	-0.1	-0.2	1.0	-0.9	0.3	1.1
Birth weight of first child	2.2	4.0	13.0	-3.6	-1.5	-0.9	-2.7	-0.1	-0.7
Peak expiratory flow (PEF)	1.8	4.1	16.0	0.5	1.4	1.1	1.9	1.3	4.0
Pulse wave reflection index	1.0	1.2	5.3	0.6	2.3	-0.7	-0.4	-0.9	-0.2
Ever highly irritable/argumentative for 2 days	0.9	1.0	1.9	1.4	1.0	0.9	1.1	0.5	0.9
Loud music exposure frequency	0.7	0.7	1.9	-0.2	1.4	0.3	-1.1	-0.0	-1.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.0	-0.6	-1.5	1.7	1.5	1.2	0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.0	-0.7	-1.4	-0.1	0.6	0.6	-0.1
Blood clot in the leg (DVT)	1.6	2.1	3.5	-0.7	0.0	1.8	-1.3	-1.9	-1.8
Medication: Paracetamol	0.1	0.2	0.8	0.3	-0.1	0.9	0.1	-0.4	0.4
Headache pain in last month	0.9	1.6	3.4	1.2	0.9	1.8	-1.1	-1.7	0.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.9	-0.3	0.6	0.7	0.1	-0.3	1.7
Glaucoma (self-reported)	0.6	0.7	3.1	-1.1	-1.8	-0.2	-0.0	0.3	-0.2
Gout (self-reported)	0.7	0.9	3.0	1.4	1.7	0.6	0.3	0.4	-0.0
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.2	0.5	-0.1	0.3	-1.5	-1.2	-1.5
Medication: Amlodipine	0.9	1.2	3.0	-0.1	-0.4	-1.6	0.1	-1.3	-1.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.8	0.2	-0.4	-0.1	-0.3	-0.3	-1.3
Birth weight	1.6	3.5	10.1	-1.7	-1.7	1.0	-3.2	-2.0	0.3
Chronic bronchitis/emphysema (mother)	1.3	1.5	6.1	0.0	0.4	-0.6	-1.3	-2.5	-0.8
High blood pressure (siblings)	0.2	0.3	0.8	0.9	0.3	-0.5	-0.2	-0.4	-0.8
Forced vital capacity (FVC), Best measure	0.8	3.1	14.1	-0.0	1.1	-0.1	1.7	0.5	3.8
Body fat percentage	0.3	1.1	2.4	0.4	0.5	1.2	-1.5	-1.5	-0.6
Leg fat percentage (right)	0.3	1.1	2.2	0.5	-0.1	0.9	-1.5	-1.4	-1.2
Arm fat-free mass (right)	0.3	1.4	2.3	-1.1	1.4	0.9	-1.2	-0.8	1.5
Exposure to tobacco smoke outside home	0.9	1.2	2.3	0.6	1.2	-0.6	-1.0	-1.5	-1.3
Comparative body size at age 10	0.1	0.4	1.1	-0.1	-0.4	0.9	-1.0	0.0	0.1
Number of full brothers	1.5	1.9	5.5	-1.1	0.2	-0.5	-2.4	-0.5	-2.0
Worry too long after embarrassment	0.5	0.9	1.9	0.6	1.0	1.2	-1.4	0.2	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.1	-1.4	-1.2	0.6	-1.0	1.2	-0.7
Wheeze or whistling in the chest in last year	1.6	2.8	9.0	1.1	-0.4	0.3	-1.3	-2.2	-3.0
Number of children fathered	0.6	0.7	1.4	0.3	-1.2	0.6	0.9	-0.8	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	6.8	-0.7	-1.6	0.2	1.2	2.6	0.8
Age at first live birth	1.7	3.0	8.7	-0.9	-1.6	-0.8	1.3	3.0	2.0
Pulse wave peak to peak time	1.8	2.1	3.5	1.4	-0.7	1.6	1.5	1.9	1.2
Health satisfaction	0.9	1.2	2.1	0.9	0.9	0.9	-1.5	-1.2	-1.0
Shortness of breath walking on level ground	0.5	0.6	1.9	1.4	0.1	0.3	0.5	-0.9	-0.6
Qualifications: College or University degree	1.8	5.8	13.8	-1.8	-0.9	-0.3	3.5	3.7	2.3
Eye problems/disorders: None of the above	1.0	1.2	3.2	0.6	1.8	-1.1	-0.9	-1.2	-0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	-0.3	-1.2	0.8	-0.5	0.0	-1.1
Emphysema/chronic bronchitis	1.2	1.4	4.9	2.2	0.9	-0.4	0.0	-1.5	-0.3
Medication for pain relief, constipation, heartburn	0.8	1.3	3.6	-1.9	-1.4	-1.1	0.6	0.5	-0.6
Neck or shoulder pain in last month	2.6	3.7	10.1	2.2	3.2	1.4	-1.4	-0.7	1.7
Medication: Blood pressure	0.4	0.7	1.8	0.0	-1.1	-1.0	-0.3	0.4	-1.3
Angina (self-reported)	1.5	1.9	4.6	1.6	1.9	0.4	-2.1	-0.7	-0.4
Migraine (self-reported)	0.1	0.2	0.4	0.2	-0.3	0.4	0.6	-0.1	0.5
Medication: Ibuprofen	1.4	1.7	4.5	-0.6	-1.1	0.6	-1.1	-2.1	-1.7
Medication: Allopurinol	0.4	0.5	0.9	-0.9	0.7	-0.2	-0.1	1.0	-1.0
Medication: Omeprazole	0.7	0.8	2.8	0.3	0.9	-0.2	1.0	1.7	0.2
Medication: Seretide 50 evohaler	0.8	0.9	2.9	-0.1	-0.8	-0.0	-0.1	-1.7	-1.3
Mean time to correctly identify matches	0.4	0.7	1.5	0.6	-0.4	-0.4	-1.2	-0.9	-1.1
Heart disease (mother)	1.2	1.4	3.5	-0.6	0.6	1.0	-1.0	-1.5	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.0	1.4	0.4	-0.8	-0.4	-0.9	0.2
Whole body fat mass	0.3	1.4	2.7	-0.1	1.1	1.4	-1.6	-1.6	0.0
Leg fat mass (right)	0.4	1.7	3.8	-0.0	0.6	1.4	-1.9	-1.9	-0.6
Arm predicted mass (right)	0.3	1.6	2.5	-1.1	1.6	0.9	-1.3	-1.0	1.6
Pulse rate, automated reading	0.2	0.5	1.6	-0.2	-0.5	1.3	0.5	-0.0	-1.0
Alcohol intake frequency.	0.4	0.9	2.8	0.2	-0.2	-0.2	-1.7	-1.3	-0.8
Comparative height size at age 10	0.1	0.7	2.5	-1.6	-0.4	-0.9	-0.4	-0.4	-0.5
Number of full sisters	1.5	1.9	5.8	-0.8	-0.3	1.6	-0.6	-1.3	-2.4
Suffer from ‘nerves’	0.1	0.1	0.5	0.0	0.1	0.2	-0.4	0.7	0.1
Overall health rating	2.3	4.9	11.4	1.4	1.9	1.4	-3.4	-2.5	-2.0
Chest pain or discomfort	0.3	0.5	1.7	-0.1	0.4	1.3	-0.9	0.0	-0.4
Had major operations	0.3	0.4	1.2	0.1	0.4	-0.6	0.7	0.0	1.1
Age at last live birth	0.6	0.9	3.0	-1.3	0.1	0.9	0.1	1.7	0.1
Family relationship satisfaction	0.4	0.5	1.1	0.6	0.9	0.3	-1.1	-0.7	-0.3
Leg pain on walking	0.4	0.5	1.5	1.2	0.7	-0.2	-0.2	-0.8	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.2	0.3	-0.1	1.8	-0.4	-0.5	-1.6
Commuting to job workplace: Car/motor vehicle	1.6	1.8	4.9	-1.6	-1.0	-2.2	1.5	-0.1	-0.4
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.9	0.5	-0.6	-1.3	-1.7	-0.5	-0.8
Medication: Aspirin	1.4	1.9	6.1	1.9	0.9	2.5	-0.4	-0.0	-0.8
Supplements: Vitamin C	2.1	2.5	9.2	-1.0	-1.3	1.3	1.1	3.0	0.2
Knee pain experienced in last month	1.9	3.0	8.1	0.8	0.2	0.1	-2.0	-2.2	-2.8
Hypertension (Self-reported)	0.2	0.6	1.6	-1.1	-0.6	-0.1	0.2	1.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.9	0.1	0.7	-0.4	-1.0	-0.2	-0.9
Illnesses of father: Heart disease	0.7	1.0	2.1	1.4	1.4	0.2	-0.6	0.7	1.0
Illnesses of siblings: Diabetes	1.2	1.4	3.2	1.2	0.8	0.3	1.8	1.2	1.3
Smoking status: Previous	1.9	2.9	6.6	-1.2	-0.0	-1.4	-1.5	-2.6	-2.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.9	-1.0	0.9	1.7	0.3	0.5	0.2
Whole body fat-free mass	0.3	1.9	4.3	-2.1	1.1	1.0	-1.5	-1.4	0.6
Leg fat-free mass (right)	0.5	2.5	5.0	-1.8	1.7	0.9	-1.7	-2.2	0.6
Arm fat percentage (left)	0.3	1.4	2.9	0.1	1.1	0.9	-1.7	-1.7	-0.8
Average weekly red wine intake	2.3	3.4	7.5	-1.3	-1.4	-2.7	1.6	1.3	2.3
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.1	-1.5	-0.2	1.1	-0.5	0.3	-0.9
Mood swings	1.7	3.1	8.4	1.0	2.9	2.5	-0.7	-1.3	-1.1
Loneliness, isolation	1.2	1.6	6.1	0.4	-0.6	-0.6	-2.5	-1.2	-1.2
Long-standing illness, disability or infirmity	1.7	2.6	8.4	0.7	0.5	-0.7	-1.6	-2.9	-1.8
Ever had bowel cancer screening	1.2	1.4	2.9	0.3	1.2	-0.4	1.6	1.2	1.7
Diabetes diagnosed by doctor	0.1	0.2	0.3	0.2	0.5	-0.5	0.3	0.4	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	4.8	-1.8	1.6	0.9	-2.2	0.2	-1.5
Friendships satisfaction	1.9	2.4	5.0	-0.6	0.4	0.7	-2.2	-2.1	-1.9
Qualifications: nursing, teaching	1.9	3.0	7.7	-2.8	-2.0	-0.9	1.5	1.6	0.9
Commuting to job workplace: Walk	1.4	1.5	3.2	0.8	0.2	1.3	1.3	1.8	1.4
Eye problems/disorders: Cataract	0.4	0.4	1.1	-1.1	-0.7	0.1	0.4	0.5	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	4.6	-0.0	0.7	-2.1	0.4	-0.4	0.6
Medication for cholesterol	0.4	0.6	2.1	-0.3	-1.1	-0.2	-0.1	0.1	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.4	-0.4	-0.5	0.4	1.2	0.9	0.5
Back pain experienced in last month	1.6	2.4	5.4	1.2	1.6	-0.4	-2.1	-2.3	0.5
Mineral and other dietary supplements	1.7	2.3	5.1	-1.4	0.6	0.7	-2.2	-1.6	-1.8
Breast cancer (self-reported)	0.9	1.0	3.0	-1.1	-1.1	0.1	-0.3	1.7	0.8
Asthma (self-reported)	0.7	1.4	4.4	-1.1	-0.9	-0.1	-0.9	-1.2	-2.1
Osteoporosis (self-reported)	3.6	4.5	13.6	1.8	0.5	-1.0	2.5	1.6	3.7
Osteoarthritis (self-reported)	0.5	0.6	2.2	1.5	0.7	0.1	-0.6	-0.5	0.5
Medication: Aspirin	1.5	2.0	5.3	2.1	1.4	2.3	-0.3	0.1	-0.3
Medication: Gliclazide	0.5	0.6	2.7	1.6	0.6	-0.1	-0.3	-0.2	0.4
Illnesses of father: None of the above (group 1)	0.7	0.9	2.8	-0.3	-1.3	0.4	1.7	-0.4	0.4
Smoking status: Current	2.7	4.2	14.2	0.8	0.2	1.5	-1.4	-2.5	-3.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	5.8	-1.5	-2.4	-1.4	2.1	1.1	2.4
Whole body water mass	0.3	1.9	4.0	-2.0	1.2	1.0	-1.5	-1.5	0.7
Leg predicted mass (right)	0.5	2.6	5.2	-1.9	1.7	0.9	-1.7	-2.3	0.5
Arm fat mass (left)	0.4	1.7	3.5	-0.3	1.4	0.9	-1.9	-1.8	-0.2
Number of self-reported non-cancer illnesses	0.2	0.3	0.6	-0.5	0.6	0.8	-0.3	0.5	-0.2
Average weekly champagne plus white wine intake	0.4	0.6	1.6	0.5	1.3	-0.4	0.2	-0.5	1.1
Miserableness	1.0	1.7	4.2	0.8	2.0	0.7	-1.0	-1.8	-0.8
Guilty feelings	1.7	2.6	6.1	0.9	1.1	0.7	-2.5	-2.0	-1.7
Wears glasses or contact lenses	1.2	1.4	4.2	0.3	-0.9	-0.9	0.8	1.3	2.0
Ever taken oral contraceptive pill	1.3	1.4	3.3	0.5	-0.8	0.2	1.6	1.4	1.8
Hearing aid user	0.5	0.5	1.9	-0.1	-1.4	0.0	0.4	-0.6	-0.9
Mother’s age at death	1.1	1.3	2.9	-0.8	-1.7	-1.4	1.0	0.7	1.0
Financial situation satisfaction	0.9	1.1	2.3	-1.0	-0.3	-0.5	-1.2	-1.2	-1.5
Tinnitus: Yes, now most or all of the time	1.1	1.2	2.1	-0.1	1.3	-1.1	-1.0	-1.4	-1.2
Commuting to job workplace: Public transport	0.6	0.8	2.5	0.9	-0.9	1.6	-0.4	-0.2	0.4
Eye problems/disorders: Glaucoma	0.5	0.5	1.3	-0.2	-0.7	-1.1	-1.2	0.4	-0.2
Medication: Blood pressure	0.3	0.6	1.3	0.5	1.1	1.2	-0.4	0.0	-1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.0	0.1	-1.4	0.8	0.0	-0.2	0.4
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.3	0.3	-2.1	-0.4	2.0	1.2	0.2
High cholesterol (Self-reported)	0.5	0.9	1.8	1.0	0.9	0.5	0.8	-0.9	-1.3
Medication: Bendroflumethiazide	0.6	1.0	2.1	-1.0	-0.3	0.0	-1.4	-0.8	-1.5
Medication: Paracetamol	0.1	0.1	0.6	0.3	-0.1	-0.0	0.3	-0.8	-0.2
Medication: Lisinopril	0.5	0.6	1.1	1.1	1.1	-0.3	0.6	-1.0	0.1
Medication: Atorvastatin	1.0	1.3	3.4	1.8	1.7	-0.7	0.9	-0.1	0.4
Illnesses of father: High blood pressure	0.2	0.2	0.7	0.2	0.3	-0.6	0.1	0.8	0.0
Alcohol drinker status: Never	0.3	0.4	0.9	0.6	0.0	-0.7	0.3	-1.0	0.6
Ever smoked	2.2	3.9	14.0	-0.0	0.2	0.3	-1.4	-2.7	-3.7
Basal metabolic rate	0.3	1.9	3.0	-1.7	1.2	1.1	-1.6	-1.7	0.6
Leg fat percentage (left)	0.3	1.0	2.7	0.5	-0.1	0.6	-1.4	-1.6	-1.0
Arm fat-free mass (left)	0.3	1.3	2.3	-1.5	0.8	1.1	-1.3	-1.1	0.8
Number of operations (self-reported)	0.6	0.9	2.9	-1.7	-0.3	-0.0	-1.2	-0.3	-1.0
Average weekly beer plus cider intake	0.4	0.5	1.4	-1.0	-0.5	1.2	-0.2	-0.6	-0.5
Irritability	0.4	0.7	1.9	0.7	1.4	0.1	-1.0	-0.9	-0.4
Risk taking	0.8	1.1	3.0	-1.0	-1.4	-0.1	0.4	-0.7	-1.7
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.9	-0.8	-0.6	-0.4	0.6	1.0	-0.7
Fractured/broken bones in last 5 years	0.5	0.7	2.5	-0.3	1.6	-1.0	-0.5	-0.2	0.1
Age started oral contraceptive pill	2.6	3.3	7.8	0.5	-0.6	-1.9	1.6	2.2	2.8
Diastolic blood pressure, automated reading	0.2	0.8	2.7	-0.3	0.2	-0.3	1.0	1.7	0.7
Ever depressed for a whole week	1.1	1.4	5.6	1.0	0.4	0.2	-2.4	-1.2	-0.3
Unable to work because of sickness or disability	0.4	0.6	2.0	-0.5	0.0	0.7	-0.3	-1.4	-0.7
Commuting to job workplace: Cycle	0.7	0.9	2.2	0.4	0.4	0.2	-0.7	1.5	1.5
Myopia	0.5	0.7	1.9	0.3	-0.2	1.3	1.4	0.3	0.6
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.6	-0.1	-0.7	0.0	-0.1	-0.8	-0.0
Cholesterol lowering medication	0.7	1.1	2.9	0.4	0.8	1.7	0.0	-1.3	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.7	0.3	1.2	-0.6	1.0	1.3	0.8
Pain experienced in last month	3.7	6.2	15.1	-1.6	-2.7	-0.7	3.9	3.0	1.6
Supplements: Calcium	2.4	2.7	4.7	2.1	2.0	-1.5	0.5	0.3	2.2
Basal cell carcinoma (self-reported)	1.8	2.1	4.2	0.6	1.7	0.9	2.0	1.7	1.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.8	1.7	0.6	-0.5	-0.5	-0.3	-1.3
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	2.8	-0.7	-0.1	1.6	-1.1	-1.7	-1.7
Heart disease (siblings)	1.3	1.6	4.4	-0.4	-1.3	-1.4	0.7	0.8	2.1
Alcohol drinker status: Previous	1.1	1.3	3.5	-1.9	0.3	-0.6	-1.4	-0.6	-1.2
Pack years of smoking	1.6	2.4	6.2	1.3	0.6	0.7	-0.1	-2.3	-2.5
Impedance of whole body	0.4	2.0	4.0	1.1	-1.6	-0.5	2.0	1.9	0.7
Leg fat mass (left)	0.4	1.6	3.8	0.0	0.7	1.3	-1.8	-2.0	-0.5
Arm predicted mass (left)	0.3	1.3	1.9	-1.3	0.8	1.2	-1.4	-1.2	0.8