Hub : Genes

HADHA

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.0668 0.0324 3.3e-03 0.008 NA 0.010 NA 0.007 5.1e-02 NA 3.4e-02 NA 6.1e-02
2 GTEx Pituitary 0.2000 0.0770 1.5e-03 0.080 NA 0.033 NA 0.059 4.8e-03 NA 5.2e-02 NA 1.3e-02
3 GTEx Testis 0.2020 0.0620 1.0e-06 0.186 NA 0.181 NA 0.173 1.1e-08 NA 1.9e-08 NA 4.1e-08
4 YFS Blood 0.0827 0.0179 0.0e+00 0.155 0.146 0.151 0.154 0.153 1.9e-48 2.4e-45 6.1e-47 4.7e-48 1.3e-47
5 TCGA Thyroid Carcinoma 0.0320 0.0250 2.4e-03 0.036 0.029 0.032 NA 0.034 1.8e-04 6.7e-04 4.3e-04 NA 2.5e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.6 0.9 1.5 1.2 -0.7 -0.9 0.9 -0.9
Bipolar Disorder or Schizophrenia 1.6 3.9 5.6 1.6 -2.4 -1.9 2.0 -2.0
Depressed Affect (Nagel 2018) 0.1 0.3 1.1 0.3 -1.1 -0.1 0.1 -0.1
Depression (Nagel 2018) 0.3 0.4 0.7 -0.8 -0.4 0.6 -0.7 0.8
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.3 -0.4 0.6 0.2 -0.4 0.2
Neuroticism (Nagel 2018) 0.2 0.6 2.4 -0.2 -1.5 -0.4 0.5 -0.2
Schizophrenia (2018) 1.6 3.4 6.2 1.1 -2.5 -1.8 1.8 -1.8
Schizophrenia vs Biploar Disorder 0.4 0.6 1.8 -0.8 -1.4 -0.3 0.4 -0.3
Worry (Nagel 2018) 0.6 1.3 2.0 -0.1 -1.4 -1.2 1.4 -1.0
Alzheimer’s Disease (in mother) 2.0 2.3 4.6 -2.1 1.7 1.2 -1.1 1.2
Alzheimer’s Disease (in father) 0.3 0.4 1.4 -0.6 1.2 -0.1 0.0 -0.1
Alzheimer’s Disease (including proxy) 0.5 0.8 3.2 -1.8 0.6 0.3 -0.3 0.1
Crohns Disease (2017) 0.3 0.6 0.8 -0.7 0.7 0.9 -0.9 0.8
Irritable Bowel Disease (IBD) 0.4 1.0 2.3 -0.7 1.5 0.9 -0.9 0.8
Ulcerative Colitis (UC) 0.5 1.0 3.5 -0.3 1.9 0.7 -0.7 0.7
Major Depression (MDD) 3.3 4.0 5.3 2.2 -2.3 -1.7 1.9 -1.9
Reaction Time 0.1 0.2 0.3 -0.5 0.3 0.5 -0.5 0.6
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.3 -0.5 0.3 -0.1 0.1 -0.2
Breast Cancer 0.8 2.0 6.4 -2.5 -0.0 1.1 -1.2 1.1
Ovarian Cancer 0.1 0.2 0.2 0.4 0.3 -0.5 0.2 -0.5
Prostate Cancer 0.2 0.3 0.4 0.5 0.0 -0.7 0.7 -0.6
Age at First Birth 0.4 0.7 1.1 0.4 0.4 -0.9 1.1 -1.0
Bipolar Disorder (2011) 0.1 0.1 0.5 -0.2 -0.7 0.2 -0.1 0.3
Body Mass Index (BMI) (2010) 0.4 0.5 0.9 -1.0 -0.7 0.7 -0.7 0.6
Coronary Artery Disease (CAD) 0.6 0.7 1.1 0.7 -1.0 -0.8 0.8 -0.7
Crohns Disease (2012) 0.2 0.3 1.5 -0.1 1.2 0.2 -0.0 0.1
Mean Putamen Volume 0.8 0.9 1.7 0.1 0.0 1.1 -1.3 1.2
Fasting Glucose 1.5 1.8 2.8 1.0 1.7 -1.3 1.4 -1.3
HbA1C 0.4 0.5 0.8 0.6 0.3 -0.8 0.8 -0.9
HDL Cholesterol 0.3 0.5 0.7 -0.8 -0.3 0.8 -0.7 0.8
LDL Cholesterol 0.7 1.0 1.8 -0.5 0.2 1.2 -1.4 1.3
Lupus 0.6 0.8 2.4 -0.0 1.6 0.8 -0.7 0.8
Neuroticism (2016) 1.0 1.4 2.5 1.0 -0.4 -1.6 1.5 -1.2
Primary Biliary Cirrhosis 0.1 0.1 0.5 -0.3 0.7 -0.0 0.2 -0.1
Rheumatoid Arthritis 0.9 1.2 2.9 -0.1 1.7 1.1 -0.9 1.0
Schizophrenia (2014) 1.2 2.6 3.7 1.2 -1.9 -1.6 1.6 -1.6
Triglycerides 0.7 1.2 1.9 -1.1 -0.1 1.2 -1.4 1.1
Type 2 Diabetes (T2D) (2012) 2.2 2.5 9.3 1.3 -3.1 -0.8 0.6 -0.7
Ulcerative Colitis 0.6 0.9 2.7 -0.6 1.6 0.7 -0.6 0.8
Blood Eosinophil Count 0.0 0.4 0.6 -0.2 -0.5 -0.7 0.8 -0.7
Blood Platelet Count 1.1 13.2 19.5 4.4 -1.9 -3.9 3.6 -3.9
Blood Red Count 0.8 7.4 15.4 3.9 -1.7 -2.6 2.6 -2.4
Blood White Count 0.2 1.8 3.0 1.3 -0.2 -1.7 1.4 -1.6
Heel T-Score 0.3 2.3 3.8 1.9 -0.9 -1.6 1.5 -1.5
BMI 0.2 0.9 2.0 0.9 -1.4 -0.6 0.9 -0.7
Height 1.0 19.5 26.5 -4.5 5.2 4.4 -3.6 4.3
Waist Hip Ratio (WHR) 0.2 0.9 2.3 -1.0 1.5 0.7 -0.4 0.6
Systolic Blood Pressure 0.4 2.1 4.9 2.2 0.3 -1.3 1.4 -1.2
Smoking Status 1.1 2.6 3.5 -1.7 -0.2 1.9 -1.8 1.9
Allergy or Eczema 0.4 1.2 2.3 0.6 -1.5 -1.0 1.0 -1.0
Cardiovascular Disease 0.1 0.2 0.6 0.7 -0.1 -0.4 0.6 -0.3
Hypothyroidism (self reported) 0.0 0.0 0.1 0.3 -0.1 0.2 -0.2 0.2
Respiratory disease 1.2 2.7 5.6 1.6 -2.4 -1.3 1.4 -1.2
Type 2 Diabetes (T2D) (2018) 1.4 2.6 4.2 1.7 -0.3 -1.6 2.0 -1.7
Lung FEV1/FVC ratio 0.2 1.2 5.0 -0.4 -2.2 -0.6 0.6 -0.6
Lung FVC 0.2 1.0 1.7 1.3 1.3 0.6 -1.0 0.6
Neuroticism 0.1 0.2 1.0 -0.1 -1.0 -0.2 0.2 -0.1
Chronotype (morning person) 0.1 0.3 0.7 0.8 0.5 -0.3 0.4 -0.4
Hair Pigment 0.0 0.9 2.1 -1.1 0.1 0.9 -1.4 0.8
Tanning 0.1 1.1 2.0 0.8 -0.4 -1.1 1.4 -1.1
Hand grip strength (left) 1.0 2.7 4.4 -2.1 0.1 1.7 -1.7 1.8
Number of treatments/medications taken 0.0 0.0 0.1 -0.2 0.1 -0.2 0.3 -0.1
Average weekly spirits intake 2.2 2.7 5.2 2.3 -1.9 -1.2 1.4 -1.2
Sensitivity / hurt feelings 0.7 1.2 1.8 0.7 -0.9 -1.2 1.4 -1.2
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.4 -0.6 -0.4 0.6 -0.5 0.6
Hearing difficulty/problems: Yes 0.1 0.2 0.3 -0.6 -0.0 0.5 -0.5 0.5
Relative age of first facial hair 0.1 0.2 0.4 0.1 0.6 0.4 -0.6 0.4
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.6 1.3 0.8 -0.5 0.4 -0.5
Ever used hormone-replacement therapy (HRT) 1.1 1.4 2.1 -1.3 0.2 1.4 -1.2 1.4
Ever had hysterectomy (womb removed) 0.5 0.5 0.7 0.7 0.3 -0.8 0.8 -0.8
Systolic blood pressure, automated reading 0.8 2.2 5.0 2.2 -0.4 -1.4 1.4 -1.3
Eye problems/disorders: Diabetes related eye disease 2.7 3.0 3.8 1.9 -1.5 -1.7 1.8 -1.7
Angina 1.5 1.9 3.1 1.6 -1.8 -1.1 1.2 -1.1
Medication for hormone replacement therapy 3.0 3.4 3.9 1.6 -1.8 -2.0 1.9 -1.9
Vitamin and mineral supplements 0.1 0.1 0.2 -0.1 -0.5 -0.3 0.1 -0.2
Supplements: Zinc 1.7 1.9 2.0 -1.3 1.4 1.4 -1.4 1.4
Medication: Co-codamol 2.5 2.8 4.6 0.9 -1.1 -1.9 2.2 -2.0
Medication: Metformin 1.1 1.5 2.7 1.0 0.1 -1.3 1.7 -1.4
Diabetes (father) 1.3 1.7 3.1 1.8 -1.2 -1.2 1.0 -1.1
Diabetes (mother) 0.8 1.0 1.5 -0.9 0.5 1.2 -1.1 1.2
Severe depression (siblings) 0.6 0.7 1.5 0.4 -1.2 -0.7 0.8 -0.7
Pack years adult smoking proportion 0.5 0.8 2.4 -0.2 1.6 -0.7 0.7 -0.7
Impedance of leg (right) 0.1 0.4 1.0 0.2 -1.0 -0.6 0.3 -0.7
Leg fat-free mass (left) 0.0 0.1 0.4 -0.1 0.6 0.3 0.3 0.2
Trunk fat percentage 1.2 4.8 6.1 2.1 -1.9 -2.1 2.5 -2.2
Hand grip strength (right) 0.5 1.4 1.9 -1.4 0.5 1.2 -1.2 1.3
Townsend deprivation index at recruitment 0.2 0.2 0.4 -0.2 -0.4 0.6 -0.5 0.6
Current tobacco smoking 1.2 2.0 3.6 -1.9 0.7 1.5 -1.4 1.4
Average weekly fortified wine intake 0.5 0.6 2.5 -0.3 -1.6 -0.3 0.4 -0.3
Maternal smoking around birth 0.0 0.1 0.2 -0.5 -0.0 0.1 -0.2 0.2
Fed-up feelings 0.2 0.4 0.5 -0.6 -0.7 0.7 -0.6 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.1 -0.2 0.2 -0.1 0.1 -0.1
Relative age voice broke 1.2 1.8 3.1 -1.2 1.7 1.1 -1.4 1.1
Taking other prescription medications 0.0 0.0 0.1 0.2 0.4 -0.2 0.1 -0.2
Age when periods started (menarche) 1.1 2.7 3.5 -1.9 1.1 1.6 -1.8 1.7
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.5 0.2 0.3 0.6 -0.7 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.5 -0.5 0.2 0.6 -0.6 0.7
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.9 -1.0 -0.1 0.6 -0.5 0.6
Qualifications: CSEs or equivalent 2.9 3.8 5.0 1.7 -1.3 -2.2 2.2 -2.2
Serious illness, injury or assault to yourself 0.6 0.7 1.2 0.7 -0.5 -1.1 0.8 -1.0
High blood pressure 0.6 1.7 3.6 1.9 -0.1 -1.2 1.5 -1.0
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.9 0.0 -0.9 -0.6 0.5 -0.6
Multivitamins +/- minerals 0.7 0.9 1.7 1.3 -0.1 -0.9 1.0 -0.9
Stomach or abdominal pain in last month 0.7 0.9 1.4 0.8 0.2 -1.2 1.1 -1.2
Supplements: Glucosamine 2.4 3.1 6.2 -1.7 2.5 1.6 -1.3 1.5
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.3 0.5 -0.2 0.2 -0.3 0.2
Medication: Atenolol 0.0 0.0 0.1 0.3 -0.2 -0.0 0.2 -0.1
Medication: Levothyroxine sodium 0.0 0.0 0.1 -0.2 0.4 0.2 0.2 0.0
Sitting height 0.9 6.4 10.6 -3.2 2.6 2.4 -1.9 2.4
Chronic bronchitis/emphysema (father) 0.4 0.5 0.7 0.6 -0.8 -0.7 0.6 -0.7
High blood pressure (mother) 0.1 0.1 0.3 0.1 0.5 0.4 -0.3 0.4
Body mass index (BMI) 1.2 5.2 7.3 2.7 -1.9 -2.1 2.5 -2.1
Impedance of leg (left) 0.0 0.2 0.4 -0.6 -0.6 -0.0 -0.3 -0.1
Leg predicted mass (left) 0.0 0.2 0.5 -0.2 0.7 0.3 0.3 0.3
Trunk fat mass 0.7 2.9 4.4 1.7 -1.3 -1.6 2.1 -1.7
Waist circumference 0.5 1.9 3.0 1.7 -0.8 -1.1 1.7 -1.3
Number of incorrect matches in round 0.2 0.3 0.6 -0.8 0.6 0.6 -0.5 0.4
Past tobacco smoking 0.2 0.5 0.8 0.9 -0.0 -0.8 0.6 -0.7
Alcohol usually taken with meals 0.6 0.9 1.3 -1.0 -0.2 1.0 -1.1 1.1
Nervous feelings 0.2 0.3 0.9 -0.8 0.9 -0.1 0.2 -0.1
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 2.0 -1.3 -0.8 1.4 -1.3 1.4
Hearing difficulty/problems with background noise 0.1 0.2 0.7 0.5 -0.8 0.2 -0.3 0.2
Hair/balding pattern: Pattern 2 3.6 4.5 6.6 2.3 -2.6 -1.9 1.8 -1.9
Had menopause 0.1 0.2 0.3 -0.6 0.3 0.4 -0.2 0.3
Had other major operations 0.0 0.1 0.1 -0.0 0.2 0.3 -0.3 0.3
Forced vital capacity (FVC) 1.1 4.1 5.2 -1.5 1.7 2.2 -2.3 2.2
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.0 0.1 -0.4 0.0 -0.1 -0.1 -0.1
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.4 -0.1 -0.6 0.3 -0.4 0.4
Qualifications: None of the above 0.6 1.3 2.1 1.3 -1.4 -0.8 1.1 -0.9
Financial difficulties in last 2 years 0.5 0.7 2.3 0.6 -1.5 -0.6 0.5 -0.6
Mouth/teeth dental problems 0.4 0.7 2.2 0.2 -1.5 -0.8 0.4 -0.6
Heart attack 1.7 2.2 2.5 1.6 -1.2 -1.6 1.5 -1.5
Allergy 1.1 2.6 6.1 -1.3 2.5 1.4 -1.2 1.3
Pain all over the body in last month 0.3 0.3 1.1 -0.7 1.0 0.1 -0.2 0.0
Diabetes (self-reported) 4.5 6.9 9.6 2.7 -1.3 -2.8 3.1 -2.8
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 1.3 0.6 -0.6 -1.1 1.1 -1.1
Medication: Ramipril 0.3 0.3 0.8 0.3 0.9 0.6 -0.4 0.6
Medication: Simvastatin 0.8 1.2 2.0 0.9 -0.4 -1.2 1.4 -1.3
Fluid intelligence score 0.1 0.1 0.2 0.2 0.3 -0.4 0.3 -0.4
Illnesses of siblings 1.3 1.9 3.6 -1.9 1.5 1.0 -1.1 1.1
Neuroticism score 0.9 1.9 3.0 1.0 -1.7 -1.3 1.4 -1.3
Weight 0.1 0.6 1.2 0.9 -0.6 -0.5 1.1 -0.6
Impedance of arm (right) 0.2 0.9 2.1 0.8 -1.4 -0.9 0.4 -0.9
Arm fat percentage (right) 2.3 9.1 12.0 3.5 -2.5 -2.9 3.1 -3.0
Trunk fat-free mass 0.3 1.4 2.0 -0.9 1.4 1.4 -0.8 1.4
Hip circumference 0.9 4.0 5.3 2.3 -2.1 -1.7 2.1 -1.7
Time employed in main current job 0.2 0.2 1.0 0.3 -1.0 -0.2 -0.0 -0.1
Alcohol intake versus 10 years previously 1.0 1.5 4.0 -1.3 2.0 0.8 -0.6 0.7
Father’s age at death 1.1 1.5 4.0 -2.0 0.1 1.1 -1.1 1.1
Worrier / anxious feelings 0.2 0.4 0.6 -0.3 -0.6 -0.6 0.8 -0.6
Frequency of tiredness / lethargy in last 2 weeks 1.8 3.0 3.3 1.8 -1.8 -1.6 1.8 -1.6
Falls in the last year 0.6 0.9 2.4 1.5 -1.3 -0.3 0.2 -0.3
Hair/balding pattern: Pattern 3 2.3 3.4 6.3 -2.5 0.6 1.8 -1.9 1.8
Number of live births 0.7 1.0 2.8 0.6 -1.7 -0.8 0.7 -0.8
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 2.7 -1.0 0.8 1.5 -1.6 1.6
Pulse rate 0.2 0.4 1.9 0.0 1.4 0.2 -0.2 0.1
Happiness 0.1 0.1 0.5 0.2 -0.7 -0.1 0.1 -0.2
Noisy workplace 1.6 2.0 3.5 1.6 -1.9 -1.2 1.1 -1.2
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.3 -1.1 0.4 0.7 -0.9 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.1 1.1 -0.4 -0.7 0.8 -0.7
Mouth/teeth dental problems: Dentures 0.4 0.6 1.7 -0.7 1.3 0.7 -0.3 0.6
Asthma 1.9 3.8 5.9 2.0 -2.4 -1.6 1.8 -1.7
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.8 0.9 0.4 -1.0 1.3 -1.2
Medication: Cholesterol lowering 0.2 0.3 0.7 0.9 -0.2 -0.4 0.4 -0.4
Depression (self-reported) 0.0 0.0 0.2 -0.5 -0.1 0.0 0.0 0.1
Medication: Lansoprazole 0.0 0.1 0.1 -0.2 0.4 -0.1 0.2 -0.2
Prospective memory result 0.1 0.1 0.4 -0.0 0.6 -0.0 -0.1 -0.0
Lung cancer (father) 0.3 0.4 1.0 -0.9 -1.0 0.3 -0.3 0.3
Illnesses of mother 0.3 0.4 0.6 0.8 -0.1 -0.7 0.6 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 1.1 -0.3 1.1 1.0 -1.1 1.0
Pulse wave Arterial Stiffness index 0.2 0.3 0.5 0.4 -0.6 -0.5 0.7 -0.5
Impedance of arm (left) 0.0 0.1 0.5 -0.0 -0.7 -0.3 -0.1 -0.3
Arm fat mass (right) 1.0 4.1 5.7 2.3 -1.3 -2.0 2.4 -2.0
Trunk predicted mass 0.3 1.8 2.4 -1.1 1.5 1.5 -0.9 1.5
Standing height 1.0 10.0 14.5 -3.8 2.7 3.2 -2.8 3.2
Length of working week for main job 0.3 0.3 0.7 -0.8 -0.1 0.6 -0.3 0.6
Exposure to tobacco smoke at home 0.5 0.6 2.8 -0.1 -1.7 -0.2 0.3 -0.2
Breastfed as a baby 0.6 0.8 2.6 1.6 -0.7 -0.5 0.3 -0.4
Tense / ‘highly strung’ 0.8 1.4 2.4 0.4 -1.6 -1.1 1.4 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.9 0.6 -0.9 -0.2 0.2 -0.3
Hair/balding pattern: Pattern 4 0.0 0.0 0.1 0.1 0.3 -0.0 -0.3 0.0
Birth weight of first child 0.3 0.6 2.0 0.0 1.4 -0.4 0.6 -0.5
Peak expiratory flow (PEF) 0.1 0.1 0.4 0.2 -0.6 0.2 -0.4 0.2
Pulse wave reflection index 0.1 0.2 0.7 -0.8 -0.3 0.1 0.0 0.1
Ever highly irritable/argumentative for 2 days 0.7 0.9 2.7 -0.1 -1.6 0.7 -0.7 0.8
Loud music exposure frequency 1.8 2.0 3.8 2.0 0.1 -1.4 1.4 -1.4
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.9 -0.5 1.4 0.5 -0.7 0.5
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.5 -0.4 1.2 1.2 -0.9 0.9
Blood clot in the leg (DVT) 0.2 0.3 0.7 0.4 -0.8 0.4 -0.6 0.4
Medication: Paracetamol 0.5 0.8 1.1 0.6 -0.8 -1.1 1.0 -1.0
Headache pain in last month 0.4 0.7 1.2 1.1 -0.4 -0.8 1.0 -0.8
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.0 -1.0 0.3 0.3 -0.4 0.2
Glaucoma (self-reported) 1.6 1.9 4.4 1.1 -2.1 -1.1 1.3 -1.1
Gout (self-reported) 0.3 0.4 0.7 0.2 -0.5 0.6 -0.8 0.7
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.1 0.2 0.2 0.3 -0.2 0.3
Medication: Amlodipine 0.2 0.2 0.5 0.0 0.7 -0.4 0.7 -0.3
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.8 0.8 -0.9 -0.5 0.5 -0.5
Birth weight 0.9 2.0 4.1 -2.0 0.4 1.5 -1.2 1.4
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.7 0.0 -1.3 -0.8 0.8 -0.7
High blood pressure (siblings) 1.3 1.9 4.0 2.0 -0.6 -1.2 1.4 -1.2
Forced vital capacity (FVC), Best measure 0.6 2.1 3.2 -0.5 1.8 1.5 -1.6 1.5
Body fat percentage 1.8 6.9 8.3 2.7 -2.3 -2.6 2.9 -2.7
Leg fat percentage (right) 2.6 9.4 10.3 3.2 -2.9 -3.0 3.2 -3.1
Arm fat-free mass (right) 0.3 1.5 2.0 -1.3 1.4 1.3 -0.7 1.3
Exposure to tobacco smoke outside home 0.3 0.4 0.9 0.9 -0.9 -0.2 0.4 -0.1
Comparative body size at age 10 0.6 1.5 3.2 1.8 0.3 -1.2 1.2 -1.2
Number of full brothers 1.3 1.6 2.3 -1.4 0.5 1.4 -1.5 1.3
Worry too long after embarrassment 1.5 2.5 7.6 0.6 -2.8 -1.3 1.2 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.5 2.4 -1.6 0.2 1.3 -1.2 1.3
Wheeze or whistling in the chest in last year 0.3 0.5 1.9 1.4 0.7 -0.3 0.4 -0.3
Number of children fathered 0.8 0.8 2.9 -1.7 0.3 0.7 -0.6 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.2 -0.4 -0.4 -0.3 0.3 -0.4
Age at first live birth 1.0 1.7 3.7 -1.0 1.9 1.1 -1.3 1.1
Pulse wave peak to peak time 0.5 0.5 0.7 -0.7 0.8 0.6 -0.9 0.7
Health satisfaction 0.1 0.1 0.1 0.3 -0.0 -0.3 0.2 -0.3
Shortness of breath walking on level ground 0.8 1.0 3.1 0.7 -1.8 -0.7 0.8 -0.6
Qualifications: College or University degree 1.4 4.3 5.6 -2.0 1.9 1.9 -2.4 2.1
Eye problems/disorders: None of the above 0.1 0.1 0.2 -0.5 0.4 0.2 -0.3 0.3
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.3 0.2 0.6 -0.2 0.3 -0.3
Emphysema/chronic bronchitis 0.4 0.5 0.7 0.5 -0.6 -0.8 0.7 -0.8
Medication for pain relief, constipation, heartburn 0.2 0.3 0.6 -0.2 -0.6 0.6 -0.8 0.6
Neck or shoulder pain in last month 0.9 1.3 1.6 0.7 -1.3 -1.1 1.3 -1.2
Medication: Blood pressure 0.4 0.7 1.7 1.3 0.6 -0.6 0.8 -0.5
Angina (self-reported) 0.8 1.1 2.2 1.1 -1.5 -0.8 0.9 -0.8
Migraine (self-reported) 0.0 0.0 0.1 0.1 0.3 0.1 0.0 0.2
Medication: Ibuprofen 0.3 0.3 0.7 0.5 0.3 -0.5 0.8 -0.7
Medication: Allopurinol 0.4 0.5 1.1 1.1 -1.0 -0.5 0.2 -0.4
Medication: Omeprazole 0.1 0.1 0.5 -0.4 0.7 -0.1 0.2 -0.1
Medication: Seretide 50 evohaler 1.6 1.9 2.3 1.5 -0.8 -1.5 1.4 -1.5
Mean time to correctly identify matches 0.1 0.1 0.3 -0.1 0.6 0.3 -0.3 0.3
Heart disease (mother) 0.2 0.2 1.0 0.1 -1.0 -0.0 -0.2 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 2.9 -1.7 0.4 1.4 -1.3 1.3
Whole body fat mass 0.9 3.9 5.6 2.0 -1.4 -1.9 2.4 -2.0
Leg fat mass (right) 1.3 5.0 6.5 2.3 -1.9 -2.2 2.5 -2.2
Arm predicted mass (right) 0.2 1.3 2.1 -1.1 1.4 1.2 -0.5 1.1
Pulse rate, automated reading 0.0 0.0 0.0 -0.2 0.2 0.0 0.0 -0.1
Alcohol intake frequency. 0.1 0.1 0.6 0.1 0.8 -0.0 0.2 -0.1
Comparative height size at age 10 0.0 0.2 0.4 -0.6 0.4 0.4 0.0 0.3
Number of full sisters 0.2 0.3 0.5 -0.2 0.5 0.6 -0.7 0.6
Suffer from ‘nerves’ 0.2 0.3 1.0 -0.1 -1.0 -0.4 0.5 -0.4
Overall health rating 1.4 3.0 4.2 1.7 -0.5 -1.9 2.1 -2.0
Chest pain or discomfort 0.3 0.4 1.3 0.4 -1.1 -0.5 0.4 -0.5
Had major operations 2.3 2.7 4.2 -1.1 0.7 2.0 -2.0 1.9
Age at last live birth 1.5 2.2 4.5 -1.1 2.1 1.2 -1.4 1.3
Family relationship satisfaction 0.9 1.1 4.8 0.4 -2.2 -0.5 0.5 -0.4
Leg pain on walking 2.1 2.6 4.4 2.1 -1.8 -1.3 1.3 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 0.3 -0.0 -0.5 0.3 -0.5
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 0.1 -0.5 0.0 0.2 -0.1
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.4 0.3 0.6 -0.1 -0.1 -0.1
Medication: Aspirin 0.9 1.2 1.6 -1.1 0.5 1.3 -1.1 1.3
Supplements: Vitamin C 0.9 1.0 1.6 -0.7 0.4 1.3 -1.1 1.2
Knee pain experienced in last month 0.6 1.0 2.8 0.3 -1.7 -0.8 0.9 -0.8
Hypertension (Self-reported) 0.7 1.9 3.7 1.9 -0.3 -1.3 1.6 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.5 1.0 -1.2 -0.5 0.3 -0.4
Illnesses of father: Heart disease 0.5 0.6 0.8 0.4 -0.8 0.8 -0.9 0.9
Illnesses of siblings: Diabetes 0.2 0.3 0.9 0.7 -1.0 0.1 0.1 0.1
Smoking status: Previous 0.2 0.3 0.5 -0.5 0.0 0.7 -0.5 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 4.1 -0.0 2.0 0.9 -0.6 0.8
Whole body fat-free mass 0.2 0.9 1.4 -0.8 1.2 1.1 -0.5 1.1
Leg fat-free mass (right) 0.2 0.8 1.3 -0.8 1.1 1.0 -0.4 1.0
Arm fat percentage (left) 2.3 9.2 11.3 3.4 -2.4 -3.0 3.3 -3.0
Average weekly red wine intake 0.7 1.0 1.6 -0.8 0.4 1.2 -1.2 1.3
Handedness (chirality/laterality): Left-handed 3.3 4.0 4.6 -2.1 1.6 2.1 -2.0 2.0
Mood swings 0.3 0.5 1.3 1.2 -0.4 -0.5 0.7 -0.7
Loneliness, isolation 0.0 0.1 0.1 0.2 0.3 0.1 -0.2 0.2
Long-standing illness, disability or infirmity 0.4 0.6 1.2 0.6 0.0 -0.8 1.1 -0.9
Ever had bowel cancer screening 0.1 0.1 0.3 0.6 -0.0 -0.2 0.3 -0.1
Diabetes diagnosed by doctor 2.5 4.1 6.4 2.1 0.1 -2.2 2.5 -2.2
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 2.5 1.2 -0.3 -1.5 1.6 -1.5
Friendships satisfaction 2.5 3.2 5.8 1.3 -2.4 -1.8 1.5 -1.6
Qualifications: nursing, teaching 0.1 0.2 0.8 -0.2 0.9 0.1 -0.2 0.2
Commuting to job workplace: Walk 2.4 2.5 3.0 1.6 -1.4 -1.7 1.5 -1.7
Eye problems/disorders: Cataract 0.0 0.0 0.1 -0.3 -0.4 0.0 -0.0 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 1.0 1.0 0.0 -0.4 0.6 -0.5
Medication for cholesterol 0.4 0.5 1.1 -0.3 1.0 0.6 -0.9 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.8 0.5 -0.1 -0.7 0.9 -0.7
Back pain experienced in last month 1.5 2.2 4.8 0.9 -2.2 -1.3 1.5 -1.4
Mineral and other dietary supplements 2.0 2.7 3.7 1.6 -1.9 -1.6 1.5 -1.6
Breast cancer (self-reported) 0.5 0.6 2.6 -0.6 1.6 -0.2 0.3 -0.1
Asthma (self-reported) 1.2 2.4 4.1 1.7 -2.0 -1.3 1.4 -1.2
Osteoporosis (self-reported) 1.1 1.3 1.7 -0.9 0.9 1.3 -1.3 1.3
Osteoarthritis (self-reported) 0.3 0.4 0.6 0.4 -0.3 -0.7 0.8 -0.7
Medication: Aspirin 1.5 2.0 2.7 -1.4 0.8 1.6 -1.5 1.6
Medication: Gliclazide 0.5 0.6 0.8 0.6 -0.8 -0.7 0.9 -0.8
Illnesses of father: None of the above (group 1) 0.3 0.4 1.0 -0.9 1.0 0.0 0.1 -0.1
Smoking status: Current 1.2 1.9 3.6 -1.9 0.6 1.4 -1.4 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.2 0.3 -0.5 0.3 -0.4 0.3
Whole body water mass 0.2 1.1 1.7 -0.8 1.3 1.2 -0.6 1.2
Leg predicted mass (right) 0.2 0.9 1.4 -0.9 1.2 1.0 -0.5 1.0
Arm fat mass (left) 1.0 4.2 5.8 2.4 -1.3 -2.0 2.4 -2.0
Number of self-reported non-cancer illnesses 0.7 1.1 1.7 1.3 -0.8 -1.1 1.1 -1.0
Average weekly champagne plus white wine intake 0.0 0.1 0.1 -0.3 -0.2 0.2 -0.3 0.2
Miserableness 0.3 0.5 1.2 1.1 -0.6 -0.5 0.4 -0.5
Guilty feelings 0.1 0.2 1.1 0.1 -1.0 -0.1 -0.1 -0.1
Wears glasses or contact lenses 3.0 3.4 6.5 2.5 -0.8 -1.8 1.8 -1.8
Ever taken oral contraceptive pill 0.1 0.2 0.7 0.1 0.8 0.0 -0.3 0.2
Hearing aid user 0.1 0.1 0.1 0.3 -0.2 -0.3 0.4 -0.2
Mother’s age at death 0.7 0.8 1.3 -1.1 -1.2 0.8 -0.7 0.7
Financial situation satisfaction 0.7 0.8 2.1 0.9 -1.4 -0.8 0.5 -0.7
Tinnitus: Yes, now most or all of the time 0.3 0.4 0.8 0.9 -0.5 -0.5 0.6 -0.5
Commuting to job workplace: Public transport 0.2 0.2 0.3 0.6 -0.5 -0.5 0.4 -0.4
Eye problems/disorders: Glaucoma 0.2 0.2 0.9 -0.1 -1.0 0.3 -0.2 0.3
Medication: Blood pressure 0.2 0.4 1.0 0.6 0.2 -0.6 1.0 -0.6
Pain type(s) experienced in last month: Hip pain 3.6 4.6 5.9 1.9 -2.1 -2.0 2.4 -2.2
Supplements: Fish oil (including cod liver oil) 0.5 0.6 2.0 -0.1 1.4 0.6 -0.5 0.6
High cholesterol (Self-reported) 0.0 0.1 0.3 -0.1 0.6 -0.0 0.2 -0.1
Medication: Bendroflumethiazide 0.3 0.5 2.0 0.5 1.4 0.1 0.5 -0.0
Medication: Paracetamol 0.2 0.3 1.2 -0.1 -1.1 -0.4 0.3 -0.3
Medication: Lisinopril 1.7 2.2 4.2 2.0 -0.8 -1.4 1.6 -1.4
Medication: Atorvastatin 0.5 0.6 2.2 0.1 -1.5 -0.5 0.6 -0.4
Illnesses of father: High blood pressure 2.1 2.7 4.4 2.1 -0.3 -1.7 1.8 -1.6
Alcohol drinker status: Never 0.2 0.2 0.3 -0.2 0.1 0.6 -0.5 0.6
Ever smoked 2.0 3.5 5.4 -2.3 0.9 2.0 -1.9 1.9
Basal metabolic rate 0.1 0.4 0.8 -0.4 0.9 0.8 -0.2 0.7
Leg fat percentage (left) 2.0 7.1 8.0 2.8 -2.7 -2.5 2.7 -2.6
Arm fat-free mass (left) 0.2 0.8 1.3 -0.8 0.9 1.1 -0.5 1.1
Number of operations (self-reported) 0.2 0.3 0.5 -0.3 0.2 0.7 -0.7 0.6
Average weekly beer plus cider intake 0.0 0.0 0.0 -0.0 0.0 0.1 0.1 -0.0
Irritability 0.5 0.9 3.6 0.1 -1.9 -0.4 0.8 -0.5
Risk taking 1.5 2.2 3.5 -1.9 0.5 1.5 -1.6 1.6
Ever had prostate specific antigen (PSA) test 1.0 1.2 1.7 1.1 -0.8 -1.3 0.9 -1.2
Fractured/broken bones in last 5 years 1.6 2.0 2.6 -1.6 1.6 1.3 -1.3 1.3
Age started oral contraceptive pill 0.2 0.2 0.6 -0.8 -0.4 0.4 -0.3 0.3
Diastolic blood pressure, automated reading 1.5 4.7 11.0 3.3 -0.5 -2.0 2.1 -1.9
Ever depressed for a whole week 0.3 0.3 0.9 0.9 0.1 -0.5 0.6 -0.5
Unable to work because of sickness or disability 0.5 0.7 1.9 0.3 -1.4 -0.7 0.7 -0.6
Commuting to job workplace: Cycle 0.2 0.3 0.4 0.6 -0.6 -0.6 0.2 -0.4
Myopia 1.4 2.1 3.7 1.9 1.0 -1.4 1.3 -1.4
Vascular/heart problems diagnosed by doctor 0.6 1.7 3.4 -1.9 0.7 1.2 -1.5 1.0
Cholesterol lowering medication 0.1 0.2 0.9 -0.9 -0.0 -0.1 0.3 -0.0
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.5 -0.3 0.7 -0.4 0.4 -0.4
Pain experienced in last month 0.0 0.1 0.2 0.5 0.2 -0.1 -0.3 0.1
Supplements: Calcium 0.5 0.5 1.3 1.1 0.7 -0.4 0.5 -0.5
Basal cell carcinoma (self-reported) 0.2 0.2 0.3 -0.3 -0.1 -0.6 0.5 -0.6
Heart attack/myocardial infarction (self-reported) 1.5 1.9 2.4 1.6 -1.2 -1.4 1.4 -1.4
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.9 0.8 -1.0 -0.1 -0.1 -0.1
Heart disease (siblings) 0.4 0.5 2.5 -0.4 -1.6 0.0 0.0 -0.0
Alcohol drinker status: Previous 2.1 2.4 5.5 -1.2 2.4 1.4 -1.2 1.2
Pack years of smoking 0.5 0.7 3.0 -0.5 1.7 -0.4 0.5 -0.4
Impedance of whole body 0.0 0.1 0.4 -0.6 -0.5 0.0 -0.3 -0.1
Leg fat mass (left) 1.2 4.7 6.2 2.2 -1.8 -2.1 2.5 -2.2
Arm predicted mass (left) 0.3 1.6 2.3 -1.1 1.2 1.5 -0.9 1.5