Hub : Genes

HADHA

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0668	0.0324	3.3e-03	0.008	NA	0.010	NA	0.007	5.1e-02	NA	3.4e-02	NA	6.1e-02
2	GTEx	Pituitary	0.2000	0.0770	1.5e-03	0.080	NA	0.033	NA	0.059	4.8e-03	NA	5.2e-02	NA	1.3e-02
3	GTEx	Testis	0.2020	0.0620	1.0e-06	0.186	NA	0.181	NA	0.173	1.1e-08	NA	1.9e-08	NA	4.1e-08
4	YFS	Blood	0.0827	0.0179	0.0e+00	0.155	0.146	0.151	0.154	0.153	1.9e-48	2.4e-45	6.1e-47	4.7e-48	1.3e-47
5	TCGA	Thyroid Carcinoma	0.0320	0.0250	2.4e-03	0.036	0.029	0.032	NA	0.034	1.8e-04	6.7e-04	4.3e-04	NA	2.5e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.6	0.9	1.5	1.2	-0.7	-0.9	0.9	-0.9
Bipolar Disorder or Schizophrenia	1.6	3.9	5.6	1.6	-2.4	-1.9	2.0	-2.0
Depressed Affect (Nagel 2018)	0.1	0.3	1.1	0.3	-1.1	-0.1	0.1	-0.1
Depression (Nagel 2018)	0.3	0.4	0.7	-0.8	-0.4	0.6	-0.7	0.8
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.3	-0.4	0.6	0.2	-0.4	0.2
Neuroticism (Nagel 2018)	0.2	0.6	2.4	-0.2	-1.5	-0.4	0.5	-0.2
Schizophrenia (2018)	1.6	3.4	6.2	1.1	-2.5	-1.8	1.8	-1.8
Schizophrenia vs Biploar Disorder	0.4	0.6	1.8	-0.8	-1.4	-0.3	0.4	-0.3
Worry (Nagel 2018)	0.6	1.3	2.0	-0.1	-1.4	-1.2	1.4	-1.0
Alzheimer’s Disease (in mother)	2.0	2.3	4.6	-2.1	1.7	1.2	-1.1	1.2
Alzheimer’s Disease (in father)	0.3	0.4	1.4	-0.6	1.2	-0.1	0.0	-0.1
Alzheimer’s Disease (including proxy)	0.5	0.8	3.2	-1.8	0.6	0.3	-0.3	0.1
Crohns Disease (2017)	0.3	0.6	0.8	-0.7	0.7	0.9	-0.9	0.8
Irritable Bowel Disease (IBD)	0.4	1.0	2.3	-0.7	1.5	0.9	-0.9	0.8
Ulcerative Colitis (UC)	0.5	1.0	3.5	-0.3	1.9	0.7	-0.7	0.7
Major Depression (MDD)	3.3	4.0	5.3	2.2	-2.3	-1.7	1.9	-1.9
Reaction Time	0.1	0.2	0.3	-0.5	0.3	0.5	-0.5	0.6
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.3	-0.5	0.3	-0.1	0.1	-0.2
Breast Cancer	0.8	2.0	6.4	-2.5	-0.0	1.1	-1.2	1.1
Ovarian Cancer	0.1	0.2	0.2	0.4	0.3	-0.5	0.2	-0.5
Prostate Cancer	0.2	0.3	0.4	0.5	0.0	-0.7	0.7	-0.6
Age at First Birth	0.4	0.7	1.1	0.4	0.4	-0.9	1.1	-1.0
Bipolar Disorder (2011)	0.1	0.1	0.5	-0.2	-0.7	0.2	-0.1	0.3
Body Mass Index (BMI) (2010)	0.4	0.5	0.9	-1.0	-0.7	0.7	-0.7	0.6
Coronary Artery Disease (CAD)	0.6	0.7	1.1	0.7	-1.0	-0.8	0.8	-0.7
Crohns Disease (2012)	0.2	0.3	1.5	-0.1	1.2	0.2	-0.0	0.1
Mean Putamen Volume	0.8	0.9	1.7	0.1	0.0	1.1	-1.3	1.2
Fasting Glucose	1.5	1.8	2.8	1.0	1.7	-1.3	1.4	-1.3
HbA1C	0.4	0.5	0.8	0.6	0.3	-0.8	0.8	-0.9
HDL Cholesterol	0.3	0.5	0.7	-0.8	-0.3	0.8	-0.7	0.8
LDL Cholesterol	0.7	1.0	1.8	-0.5	0.2	1.2	-1.4	1.3
Lupus	0.6	0.8	2.4	-0.0	1.6	0.8	-0.7	0.8
Neuroticism (2016)	1.0	1.4	2.5	1.0	-0.4	-1.6	1.5	-1.2
Primary Biliary Cirrhosis	0.1	0.1	0.5	-0.3	0.7	-0.0	0.2	-0.1
Rheumatoid Arthritis	0.9	1.2	2.9	-0.1	1.7	1.1	-0.9	1.0
Schizophrenia (2014)	1.2	2.6	3.7	1.2	-1.9	-1.6	1.6	-1.6
Triglycerides	0.7	1.2	1.9	-1.1	-0.1	1.2	-1.4	1.1
Type 2 Diabetes (T2D) (2012)	2.2	2.5	9.3	1.3	-3.1	-0.8	0.6	-0.7
Ulcerative Colitis	0.6	0.9	2.7	-0.6	1.6	0.7	-0.6	0.8
Blood Eosinophil Count	0.0	0.4	0.6	-0.2	-0.5	-0.7	0.8	-0.7
Blood Platelet Count	1.1	13.2	19.5	4.4	-1.9	-3.9	3.6	-3.9
Blood Red Count	0.8	7.4	15.4	3.9	-1.7	-2.6	2.6	-2.4
Blood White Count	0.2	1.8	3.0	1.3	-0.2	-1.7	1.4	-1.6
Heel T-Score	0.3	2.3	3.8	1.9	-0.9	-1.6	1.5	-1.5
BMI	0.2	0.9	2.0	0.9	-1.4	-0.6	0.9	-0.7
Height	1.0	19.5	26.5	-4.5	5.2	4.4	-3.6	4.3
Waist Hip Ratio (WHR)	0.2	0.9	2.3	-1.0	1.5	0.7	-0.4	0.6
Systolic Blood Pressure	0.4	2.1	4.9	2.2	0.3	-1.3	1.4	-1.2
Smoking Status	1.1	2.6	3.5	-1.7	-0.2	1.9	-1.8	1.9
Allergy or Eczema	0.4	1.2	2.3	0.6	-1.5	-1.0	1.0	-1.0
Cardiovascular Disease	0.1	0.2	0.6	0.7	-0.1	-0.4	0.6	-0.3
Hypothyroidism (self reported)	0.0	0.0	0.1	0.3	-0.1	0.2	-0.2	0.2
Respiratory disease	1.2	2.7	5.6	1.6	-2.4	-1.3	1.4	-1.2
Type 2 Diabetes (T2D) (2018)	1.4	2.6	4.2	1.7	-0.3	-1.6	2.0	-1.7
Lung FEV1/FVC ratio	0.2	1.2	5.0	-0.4	-2.2	-0.6	0.6	-0.6
Lung FVC	0.2	1.0	1.7	1.3	1.3	0.6	-1.0	0.6
Neuroticism	0.1	0.2	1.0	-0.1	-1.0	-0.2	0.2	-0.1
Chronotype (morning person)	0.1	0.3	0.7	0.8	0.5	-0.3	0.4	-0.4
Hair Pigment	0.0	0.9	2.1	-1.1	0.1	0.9	-1.4	0.8
Tanning	0.1	1.1	2.0	0.8	-0.4	-1.1	1.4	-1.1
Hand grip strength (left)	1.0	2.7	4.4	-2.1	0.1	1.7	-1.7	1.8
Number of treatments/medications taken	0.0	0.0	0.1	-0.2	0.1	-0.2	0.3	-0.1
Average weekly spirits intake	2.2	2.7	5.2	2.3	-1.9	-1.2	1.4	-1.2
Sensitivity / hurt feelings	0.7	1.2	1.8	0.7	-0.9	-1.2	1.4	-1.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	-0.6	-0.4	0.6	-0.5	0.6
Hearing difficulty/problems: Yes	0.1	0.2	0.3	-0.6	-0.0	0.5	-0.5	0.5
Relative age of first facial hair	0.1	0.2	0.4	0.1	0.6	0.4	-0.6	0.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.6	1.3	0.8	-0.5	0.4	-0.5
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.1	-1.3	0.2	1.4	-1.2	1.4
Ever had hysterectomy (womb removed)	0.5	0.5	0.7	0.7	0.3	-0.8	0.8	-0.8
Systolic blood pressure, automated reading	0.8	2.2	5.0	2.2	-0.4	-1.4	1.4	-1.3
Eye problems/disorders: Diabetes related eye disease	2.7	3.0	3.8	1.9	-1.5	-1.7	1.8	-1.7
Angina	1.5	1.9	3.1	1.6	-1.8	-1.1	1.2	-1.1
Medication for hormone replacement therapy	3.0	3.4	3.9	1.6	-1.8	-2.0	1.9	-1.9
Vitamin and mineral supplements	0.1	0.1	0.2	-0.1	-0.5	-0.3	0.1	-0.2
Supplements: Zinc	1.7	1.9	2.0	-1.3	1.4	1.4	-1.4	1.4
Medication: Co-codamol	2.5	2.8	4.6	0.9	-1.1	-1.9	2.2	-2.0
Medication: Metformin	1.1	1.5	2.7	1.0	0.1	-1.3	1.7	-1.4
Diabetes (father)	1.3	1.7	3.1	1.8	-1.2	-1.2	1.0	-1.1
Diabetes (mother)	0.8	1.0	1.5	-0.9	0.5	1.2	-1.1	1.2
Severe depression (siblings)	0.6	0.7	1.5	0.4	-1.2	-0.7	0.8	-0.7
Pack years adult smoking proportion	0.5	0.8	2.4	-0.2	1.6	-0.7	0.7	-0.7
Impedance of leg (right)	0.1	0.4	1.0	0.2	-1.0	-0.6	0.3	-0.7
Leg fat-free mass (left)	0.0	0.1	0.4	-0.1	0.6	0.3	0.3	0.2
Trunk fat percentage	1.2	4.8	6.1	2.1	-1.9	-2.1	2.5	-2.2
Hand grip strength (right)	0.5	1.4	1.9	-1.4	0.5	1.2	-1.2	1.3
Townsend deprivation index at recruitment	0.2	0.2	0.4	-0.2	-0.4	0.6	-0.5	0.6
Current tobacco smoking	1.2	2.0	3.6	-1.9	0.7	1.5	-1.4	1.4
Average weekly fortified wine intake	0.5	0.6	2.5	-0.3	-1.6	-0.3	0.4	-0.3
Maternal smoking around birth	0.0	0.1	0.2	-0.5	-0.0	0.1	-0.2	0.2
Fed-up feelings	0.2	0.4	0.5	-0.6	-0.7	0.7	-0.6	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	-0.2	0.2	-0.1	0.1	-0.1
Relative age voice broke	1.2	1.8	3.1	-1.2	1.7	1.1	-1.4	1.1
Taking other prescription medications	0.0	0.0	0.1	0.2	0.4	-0.2	0.1	-0.2
Age when periods started (menarche)	1.1	2.7	3.5	-1.9	1.1	1.6	-1.8	1.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.5	0.2	0.3	0.6	-0.7	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	-0.5	0.2	0.6	-0.6	0.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	-1.0	-0.1	0.6	-0.5	0.6
Qualifications: CSEs or equivalent	2.9	3.8	5.0	1.7	-1.3	-2.2	2.2	-2.2
Serious illness, injury or assault to yourself	0.6	0.7	1.2	0.7	-0.5	-1.1	0.8	-1.0
High blood pressure	0.6	1.7	3.6	1.9	-0.1	-1.2	1.5	-1.0
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	0.0	-0.9	-0.6	0.5	-0.6
Multivitamins +/- minerals	0.7	0.9	1.7	1.3	-0.1	-0.9	1.0	-0.9
Stomach or abdominal pain in last month	0.7	0.9	1.4	0.8	0.2	-1.2	1.1	-1.2
Supplements: Glucosamine	2.4	3.1	6.2	-1.7	2.5	1.6	-1.3	1.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.5	-0.2	0.2	-0.3	0.2
Medication: Atenolol	0.0	0.0	0.1	0.3	-0.2	-0.0	0.2	-0.1
Medication: Levothyroxine sodium	0.0	0.0	0.1	-0.2	0.4	0.2	0.2	0.0
Sitting height	0.9	6.4	10.6	-3.2	2.6	2.4	-1.9	2.4
Chronic bronchitis/emphysema (father)	0.4	0.5	0.7	0.6	-0.8	-0.7	0.6	-0.7
High blood pressure (mother)	0.1	0.1	0.3	0.1	0.5	0.4	-0.3	0.4
Body mass index (BMI)	1.2	5.2	7.3	2.7	-1.9	-2.1	2.5	-2.1
Impedance of leg (left)	0.0	0.2	0.4	-0.6	-0.6	-0.0	-0.3	-0.1
Leg predicted mass (left)	0.0	0.2	0.5	-0.2	0.7	0.3	0.3	0.3
Trunk fat mass	0.7	2.9	4.4	1.7	-1.3	-1.6	2.1	-1.7
Waist circumference	0.5	1.9	3.0	1.7	-0.8	-1.1	1.7	-1.3
Number of incorrect matches in round	0.2	0.3	0.6	-0.8	0.6	0.6	-0.5	0.4
Past tobacco smoking	0.2	0.5	0.8	0.9	-0.0	-0.8	0.6	-0.7
Alcohol usually taken with meals	0.6	0.9	1.3	-1.0	-0.2	1.0	-1.1	1.1
Nervous feelings	0.2	0.3	0.9	-0.8	0.9	-0.1	0.2	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.0	-1.3	-0.8	1.4	-1.3	1.4
Hearing difficulty/problems with background noise	0.1	0.2	0.7	0.5	-0.8	0.2	-0.3	0.2
Hair/balding pattern: Pattern 2	3.6	4.5	6.6	2.3	-2.6	-1.9	1.8	-1.9
Had menopause	0.1	0.2	0.3	-0.6	0.3	0.4	-0.2	0.3
Had other major operations	0.0	0.1	0.1	-0.0	0.2	0.3	-0.3	0.3
Forced vital capacity (FVC)	1.1	4.1	5.2	-1.5	1.7	2.2	-2.3	2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	-0.4	0.0	-0.1	-0.1	-0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	-0.1	-0.6	0.3	-0.4	0.4
Qualifications: None of the above	0.6	1.3	2.1	1.3	-1.4	-0.8	1.1	-0.9
Financial difficulties in last 2 years	0.5	0.7	2.3	0.6	-1.5	-0.6	0.5	-0.6
Mouth/teeth dental problems	0.4	0.7	2.2	0.2	-1.5	-0.8	0.4	-0.6
Heart attack	1.7	2.2	2.5	1.6	-1.2	-1.6	1.5	-1.5
Allergy	1.1	2.6	6.1	-1.3	2.5	1.4	-1.2	1.3
Pain all over the body in last month	0.3	0.3	1.1	-0.7	1.0	0.1	-0.2	0.0
Diabetes (self-reported)	4.5	6.9	9.6	2.7	-1.3	-2.8	3.1	-2.8
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.3	0.6	-0.6	-1.1	1.1	-1.1
Medication: Ramipril	0.3	0.3	0.8	0.3	0.9	0.6	-0.4	0.6
Medication: Simvastatin	0.8	1.2	2.0	0.9	-0.4	-1.2	1.4	-1.3
Fluid intelligence score	0.1	0.1	0.2	0.2	0.3	-0.4	0.3	-0.4
Illnesses of siblings	1.3	1.9	3.6	-1.9	1.5	1.0	-1.1	1.1
Neuroticism score	0.9	1.9	3.0	1.0	-1.7	-1.3	1.4	-1.3
Weight	0.1	0.6	1.2	0.9	-0.6	-0.5	1.1	-0.6
Impedance of arm (right)	0.2	0.9	2.1	0.8	-1.4	-0.9	0.4	-0.9
Arm fat percentage (right)	2.3	9.1	12.0	3.5	-2.5	-2.9	3.1	-3.0
Trunk fat-free mass	0.3	1.4	2.0	-0.9	1.4	1.4	-0.8	1.4
Hip circumference	0.9	4.0	5.3	2.3	-2.1	-1.7	2.1	-1.7
Time employed in main current job	0.2	0.2	1.0	0.3	-1.0	-0.2	-0.0	-0.1
Alcohol intake versus 10 years previously	1.0	1.5	4.0	-1.3	2.0	0.8	-0.6	0.7
Father’s age at death	1.1	1.5	4.0	-2.0	0.1	1.1	-1.1	1.1
Worrier / anxious feelings	0.2	0.4	0.6	-0.3	-0.6	-0.6	0.8	-0.6
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	3.3	1.8	-1.8	-1.6	1.8	-1.6
Falls in the last year	0.6	0.9	2.4	1.5	-1.3	-0.3	0.2	-0.3
Hair/balding pattern: Pattern 3	2.3	3.4	6.3	-2.5	0.6	1.8	-1.9	1.8
Number of live births	0.7	1.0	2.8	0.6	-1.7	-0.8	0.7	-0.8
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	2.7	-1.0	0.8	1.5	-1.6	1.6
Pulse rate	0.2	0.4	1.9	0.0	1.4	0.2	-0.2	0.1
Happiness	0.1	0.1	0.5	0.2	-0.7	-0.1	0.1	-0.2
Noisy workplace	1.6	2.0	3.5	1.6	-1.9	-1.2	1.1	-1.2
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.3	-1.1	0.4	0.7	-0.9	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.1	1.1	-0.4	-0.7	0.8	-0.7
Mouth/teeth dental problems: Dentures	0.4	0.6	1.7	-0.7	1.3	0.7	-0.3	0.6
Asthma	1.9	3.8	5.9	2.0	-2.4	-1.6	1.8	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.8	0.9	0.4	-1.0	1.3	-1.2
Medication: Cholesterol lowering	0.2	0.3	0.7	0.9	-0.2	-0.4	0.4	-0.4
Depression (self-reported)	0.0	0.0	0.2	-0.5	-0.1	0.0	0.0	0.1
Medication: Lansoprazole	0.0	0.1	0.1	-0.2	0.4	-0.1	0.2	-0.2
Prospective memory result	0.1	0.1	0.4	-0.0	0.6	-0.0	-0.1	-0.0
Lung cancer (father)	0.3	0.4	1.0	-0.9	-1.0	0.3	-0.3	0.3
Illnesses of mother	0.3	0.4	0.6	0.8	-0.1	-0.7	0.6	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.1	-0.3	1.1	1.0	-1.1	1.0
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	0.4	-0.6	-0.5	0.7	-0.5
Impedance of arm (left)	0.0	0.1	0.5	-0.0	-0.7	-0.3	-0.1	-0.3
Arm fat mass (right)	1.0	4.1	5.7	2.3	-1.3	-2.0	2.4	-2.0
Trunk predicted mass	0.3	1.8	2.4	-1.1	1.5	1.5	-0.9	1.5
Standing height	1.0	10.0	14.5	-3.8	2.7	3.2	-2.8	3.2
Length of working week for main job	0.3	0.3	0.7	-0.8	-0.1	0.6	-0.3	0.6
Exposure to tobacco smoke at home	0.5	0.6	2.8	-0.1	-1.7	-0.2	0.3	-0.2
Breastfed as a baby	0.6	0.8	2.6	1.6	-0.7	-0.5	0.3	-0.4
Tense / ‘highly strung’	0.8	1.4	2.4	0.4	-1.6	-1.1	1.4	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	0.6	-0.9	-0.2	0.2	-0.3
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	0.1	0.3	-0.0	-0.3	0.0
Birth weight of first child	0.3	0.6	2.0	0.0	1.4	-0.4	0.6	-0.5
Peak expiratory flow (PEF)	0.1	0.1	0.4	0.2	-0.6	0.2	-0.4	0.2
Pulse wave reflection index	0.1	0.2	0.7	-0.8	-0.3	0.1	0.0	0.1
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.7	-0.1	-1.6	0.7	-0.7	0.8
Loud music exposure frequency	1.8	2.0	3.8	2.0	0.1	-1.4	1.4	-1.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.9	-0.5	1.4	0.5	-0.7	0.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.5	-0.4	1.2	1.2	-0.9	0.9
Blood clot in the leg (DVT)	0.2	0.3	0.7	0.4	-0.8	0.4	-0.6	0.4
Medication: Paracetamol	0.5	0.8	1.1	0.6	-0.8	-1.1	1.0	-1.0
Headache pain in last month	0.4	0.7	1.2	1.1	-0.4	-0.8	1.0	-0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	-1.0	0.3	0.3	-0.4	0.2
Glaucoma (self-reported)	1.6	1.9	4.4	1.1	-2.1	-1.1	1.3	-1.1
Gout (self-reported)	0.3	0.4	0.7	0.2	-0.5	0.6	-0.8	0.7
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	0.2	0.2	0.3	-0.2	0.3
Medication: Amlodipine	0.2	0.2	0.5	0.0	0.7	-0.4	0.7	-0.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.8	-0.9	-0.5	0.5	-0.5
Birth weight	0.9	2.0	4.1	-2.0	0.4	1.5	-1.2	1.4
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.7	0.0	-1.3	-0.8	0.8	-0.7
High blood pressure (siblings)	1.3	1.9	4.0	2.0	-0.6	-1.2	1.4	-1.2
Forced vital capacity (FVC), Best measure	0.6	2.1	3.2	-0.5	1.8	1.5	-1.6	1.5
Body fat percentage	1.8	6.9	8.3	2.7	-2.3	-2.6	2.9	-2.7
Leg fat percentage (right)	2.6	9.4	10.3	3.2	-2.9	-3.0	3.2	-3.1
Arm fat-free mass (right)	0.3	1.5	2.0	-1.3	1.4	1.3	-0.7	1.3
Exposure to tobacco smoke outside home	0.3	0.4	0.9	0.9	-0.9	-0.2	0.4	-0.1
Comparative body size at age 10	0.6	1.5	3.2	1.8	0.3	-1.2	1.2	-1.2
Number of full brothers	1.3	1.6	2.3	-1.4	0.5	1.4	-1.5	1.3
Worry too long after embarrassment	1.5	2.5	7.6	0.6	-2.8	-1.3	1.2	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	2.4	-1.6	0.2	1.3	-1.2	1.3
Wheeze or whistling in the chest in last year	0.3	0.5	1.9	1.4	0.7	-0.3	0.4	-0.3
Number of children fathered	0.8	0.8	2.9	-1.7	0.3	0.7	-0.6	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.3	-0.4
Age at first live birth	1.0	1.7	3.7	-1.0	1.9	1.1	-1.3	1.1
Pulse wave peak to peak time	0.5	0.5	0.7	-0.7	0.8	0.6	-0.9	0.7
Health satisfaction	0.1	0.1	0.1	0.3	-0.0	-0.3	0.2	-0.3
Shortness of breath walking on level ground	0.8	1.0	3.1	0.7	-1.8	-0.7	0.8	-0.6
Qualifications: College or University degree	1.4	4.3	5.6	-2.0	1.9	1.9	-2.4	2.1
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.5	0.4	0.2	-0.3	0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	0.2	0.6	-0.2	0.3	-0.3
Emphysema/chronic bronchitis	0.4	0.5	0.7	0.5	-0.6	-0.8	0.7	-0.8
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	-0.2	-0.6	0.6	-0.8	0.6
Neck or shoulder pain in last month	0.9	1.3	1.6	0.7	-1.3	-1.1	1.3	-1.2
Medication: Blood pressure	0.4	0.7	1.7	1.3	0.6	-0.6	0.8	-0.5
Angina (self-reported)	0.8	1.1	2.2	1.1	-1.5	-0.8	0.9	-0.8
Migraine (self-reported)	0.0	0.0	0.1	0.1	0.3	0.1	0.0	0.2
Medication: Ibuprofen	0.3	0.3	0.7	0.5	0.3	-0.5	0.8	-0.7
Medication: Allopurinol	0.4	0.5	1.1	1.1	-1.0	-0.5	0.2	-0.4
Medication: Omeprazole	0.1	0.1	0.5	-0.4	0.7	-0.1	0.2	-0.1
Medication: Seretide 50 evohaler	1.6	1.9	2.3	1.5	-0.8	-1.5	1.4	-1.5
Mean time to correctly identify matches	0.1	0.1	0.3	-0.1	0.6	0.3	-0.3	0.3
Heart disease (mother)	0.2	0.2	1.0	0.1	-1.0	-0.0	-0.2	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	2.9	-1.7	0.4	1.4	-1.3	1.3
Whole body fat mass	0.9	3.9	5.6	2.0	-1.4	-1.9	2.4	-2.0
Leg fat mass (right)	1.3	5.0	6.5	2.3	-1.9	-2.2	2.5	-2.2
Arm predicted mass (right)	0.2	1.3	2.1	-1.1	1.4	1.2	-0.5	1.1
Pulse rate, automated reading	0.0	0.0	0.0	-0.2	0.2	0.0	0.0	-0.1
Alcohol intake frequency.	0.1	0.1	0.6	0.1	0.8	-0.0	0.2	-0.1
Comparative height size at age 10	0.0	0.2	0.4	-0.6	0.4	0.4	0.0	0.3
Number of full sisters	0.2	0.3	0.5	-0.2	0.5	0.6	-0.7	0.6
Suffer from ‘nerves’	0.2	0.3	1.0	-0.1	-1.0	-0.4	0.5	-0.4
Overall health rating	1.4	3.0	4.2	1.7	-0.5	-1.9	2.1	-2.0
Chest pain or discomfort	0.3	0.4	1.3	0.4	-1.1	-0.5	0.4	-0.5
Had major operations	2.3	2.7	4.2	-1.1	0.7	2.0	-2.0	1.9
Age at last live birth	1.5	2.2	4.5	-1.1	2.1	1.2	-1.4	1.3
Family relationship satisfaction	0.9	1.1	4.8	0.4	-2.2	-0.5	0.5	-0.4
Leg pain on walking	2.1	2.6	4.4	2.1	-1.8	-1.3	1.3	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.3	-0.0	-0.5	0.3	-0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.1	-0.5	0.0	0.2	-0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.4	0.3	0.6	-0.1	-0.1	-0.1
Medication: Aspirin	0.9	1.2	1.6	-1.1	0.5	1.3	-1.1	1.3
Supplements: Vitamin C	0.9	1.0	1.6	-0.7	0.4	1.3	-1.1	1.2
Knee pain experienced in last month	0.6	1.0	2.8	0.3	-1.7	-0.8	0.9	-0.8
Hypertension (Self-reported)	0.7	1.9	3.7	1.9	-0.3	-1.3	1.6	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.5	1.0	-1.2	-0.5	0.3	-0.4
Illnesses of father: Heart disease	0.5	0.6	0.8	0.4	-0.8	0.8	-0.9	0.9
Illnesses of siblings: Diabetes	0.2	0.3	0.9	0.7	-1.0	0.1	0.1	0.1
Smoking status: Previous	0.2	0.3	0.5	-0.5	0.0	0.7	-0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	4.1	-0.0	2.0	0.9	-0.6	0.8
Whole body fat-free mass	0.2	0.9	1.4	-0.8	1.2	1.1	-0.5	1.1
Leg fat-free mass (right)	0.2	0.8	1.3	-0.8	1.1	1.0	-0.4	1.0
Arm fat percentage (left)	2.3	9.2	11.3	3.4	-2.4	-3.0	3.3	-3.0
Average weekly red wine intake	0.7	1.0	1.6	-0.8	0.4	1.2	-1.2	1.3
Handedness (chirality/laterality): Left-handed	3.3	4.0	4.6	-2.1	1.6	2.1	-2.0	2.0
Mood swings	0.3	0.5	1.3	1.2	-0.4	-0.5	0.7	-0.7
Loneliness, isolation	0.0	0.1	0.1	0.2	0.3	0.1	-0.2	0.2
Long-standing illness, disability or infirmity	0.4	0.6	1.2	0.6	0.0	-0.8	1.1	-0.9
Ever had bowel cancer screening	0.1	0.1	0.3	0.6	-0.0	-0.2	0.3	-0.1
Diabetes diagnosed by doctor	2.5	4.1	6.4	2.1	0.1	-2.2	2.5	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	2.5	1.2	-0.3	-1.5	1.6	-1.5
Friendships satisfaction	2.5	3.2	5.8	1.3	-2.4	-1.8	1.5	-1.6
Qualifications: nursing, teaching	0.1	0.2	0.8	-0.2	0.9	0.1	-0.2	0.2
Commuting to job workplace: Walk	2.4	2.5	3.0	1.6	-1.4	-1.7	1.5	-1.7
Eye problems/disorders: Cataract	0.0	0.0	0.1	-0.3	-0.4	0.0	-0.0	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.0	1.0	0.0	-0.4	0.6	-0.5
Medication for cholesterol	0.4	0.5	1.1	-0.3	1.0	0.6	-0.9	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	0.5	-0.1	-0.7	0.9	-0.7
Back pain experienced in last month	1.5	2.2	4.8	0.9	-2.2	-1.3	1.5	-1.4
Mineral and other dietary supplements	2.0	2.7	3.7	1.6	-1.9	-1.6	1.5	-1.6
Breast cancer (self-reported)	0.5	0.6	2.6	-0.6	1.6	-0.2	0.3	-0.1
Asthma (self-reported)	1.2	2.4	4.1	1.7	-2.0	-1.3	1.4	-1.2
Osteoporosis (self-reported)	1.1	1.3	1.7	-0.9	0.9	1.3	-1.3	1.3
Osteoarthritis (self-reported)	0.3	0.4	0.6	0.4	-0.3	-0.7	0.8	-0.7
Medication: Aspirin	1.5	2.0	2.7	-1.4	0.8	1.6	-1.5	1.6
Medication: Gliclazide	0.5	0.6	0.8	0.6	-0.8	-0.7	0.9	-0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	1.0	-0.9	1.0	0.0	0.1	-0.1
Smoking status: Current	1.2	1.9	3.6	-1.9	0.6	1.4	-1.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.2	0.3	-0.5	0.3	-0.4	0.3
Whole body water mass	0.2	1.1	1.7	-0.8	1.3	1.2	-0.6	1.2
Leg predicted mass (right)	0.2	0.9	1.4	-0.9	1.2	1.0	-0.5	1.0
Arm fat mass (left)	1.0	4.2	5.8	2.4	-1.3	-2.0	2.4	-2.0
Number of self-reported non-cancer illnesses	0.7	1.1	1.7	1.3	-0.8	-1.1	1.1	-1.0
Average weekly champagne plus white wine intake	0.0	0.1	0.1	-0.3	-0.2	0.2	-0.3	0.2
Miserableness	0.3	0.5	1.2	1.1	-0.6	-0.5	0.4	-0.5
Guilty feelings	0.1	0.2	1.1	0.1	-1.0	-0.1	-0.1	-0.1
Wears glasses or contact lenses	3.0	3.4	6.5	2.5	-0.8	-1.8	1.8	-1.8
Ever taken oral contraceptive pill	0.1	0.2	0.7	0.1	0.8	0.0	-0.3	0.2
Hearing aid user	0.1	0.1	0.1	0.3	-0.2	-0.3	0.4	-0.2
Mother’s age at death	0.7	0.8	1.3	-1.1	-1.2	0.8	-0.7	0.7
Financial situation satisfaction	0.7	0.8	2.1	0.9	-1.4	-0.8	0.5	-0.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.8	0.9	-0.5	-0.5	0.6	-0.5
Commuting to job workplace: Public transport	0.2	0.2	0.3	0.6	-0.5	-0.5	0.4	-0.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.9	-0.1	-1.0	0.3	-0.2	0.3
Medication: Blood pressure	0.2	0.4	1.0	0.6	0.2	-0.6	1.0	-0.6
Pain type(s) experienced in last month: Hip pain	3.6	4.6	5.9	1.9	-2.1	-2.0	2.4	-2.2
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.0	-0.1	1.4	0.6	-0.5	0.6
High cholesterol (Self-reported)	0.0	0.1	0.3	-0.1	0.6	-0.0	0.2	-0.1
Medication: Bendroflumethiazide	0.3	0.5	2.0	0.5	1.4	0.1	0.5	-0.0
Medication: Paracetamol	0.2	0.3	1.2	-0.1	-1.1	-0.4	0.3	-0.3
Medication: Lisinopril	1.7	2.2	4.2	2.0	-0.8	-1.4	1.6	-1.4
Medication: Atorvastatin	0.5	0.6	2.2	0.1	-1.5	-0.5	0.6	-0.4
Illnesses of father: High blood pressure	2.1	2.7	4.4	2.1	-0.3	-1.7	1.8	-1.6
Alcohol drinker status: Never	0.2	0.2	0.3	-0.2	0.1	0.6	-0.5	0.6
Ever smoked	2.0	3.5	5.4	-2.3	0.9	2.0	-1.9	1.9
Basal metabolic rate	0.1	0.4	0.8	-0.4	0.9	0.8	-0.2	0.7
Leg fat percentage (left)	2.0	7.1	8.0	2.8	-2.7	-2.5	2.7	-2.6
Arm fat-free mass (left)	0.2	0.8	1.3	-0.8	0.9	1.1	-0.5	1.1
Number of operations (self-reported)	0.2	0.3	0.5	-0.3	0.2	0.7	-0.7	0.6
Average weekly beer plus cider intake	0.0	0.0	0.0	-0.0	0.0	0.1	0.1	-0.0
Irritability	0.5	0.9	3.6	0.1	-1.9	-0.4	0.8	-0.5
Risk taking	1.5	2.2	3.5	-1.9	0.5	1.5	-1.6	1.6
Ever had prostate specific antigen (PSA) test	1.0	1.2	1.7	1.1	-0.8	-1.3	0.9	-1.2
Fractured/broken bones in last 5 years	1.6	2.0	2.6	-1.6	1.6	1.3	-1.3	1.3
Age started oral contraceptive pill	0.2	0.2	0.6	-0.8	-0.4	0.4	-0.3	0.3
Diastolic blood pressure, automated reading	1.5	4.7	11.0	3.3	-0.5	-2.0	2.1	-1.9
Ever depressed for a whole week	0.3	0.3	0.9	0.9	0.1	-0.5	0.6	-0.5
Unable to work because of sickness or disability	0.5	0.7	1.9	0.3	-1.4	-0.7	0.7	-0.6
Commuting to job workplace: Cycle	0.2	0.3	0.4	0.6	-0.6	-0.6	0.2	-0.4
Myopia	1.4	2.1	3.7	1.9	1.0	-1.4	1.3	-1.4
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.4	-1.9	0.7	1.2	-1.5	1.0
Cholesterol lowering medication	0.1	0.2	0.9	-0.9	-0.0	-0.1	0.3	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	-0.3	0.7	-0.4	0.4	-0.4
Pain experienced in last month	0.0	0.1	0.2	0.5	0.2	-0.1	-0.3	0.1
Supplements: Calcium	0.5	0.5	1.3	1.1	0.7	-0.4	0.5	-0.5
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	-0.3	-0.1	-0.6	0.5	-0.6
Heart attack/myocardial infarction (self-reported)	1.5	1.9	2.4	1.6	-1.2	-1.4	1.4	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.9	0.8	-1.0	-0.1	-0.1	-0.1
Heart disease (siblings)	0.4	0.5	2.5	-0.4	-1.6	0.0	0.0	-0.0
Alcohol drinker status: Previous	2.1	2.4	5.5	-1.2	2.4	1.4	-1.2	1.2
Pack years of smoking	0.5	0.7	3.0	-0.5	1.7	-0.4	0.5	-0.4
Impedance of whole body	0.0	0.1	0.4	-0.6	-0.5	0.0	-0.3	-0.1
Leg fat mass (left)	1.2	4.7	6.2	2.2	-1.8	-2.1	2.5	-2.2
Arm predicted mass (left)	0.3	1.6	2.3	-1.1	1.2	1.5	-0.9	1.5