Hub : Genes

HAVCR2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Breast Mammary Tissue (Female) 0.1398 0.0646 1.1e-02 -0.003 NA -0.003 NA 0.008 4.0e-01 NA 4.1e-01 NA 1.8e-01
2 GTEx Testis 0.2760 0.0650 1.2e-06 0.158 NA 0.136 NA 0.131 1.7e-07 NA 1.3e-06 NA 2.1e-06
3 TCGA Breast Invasive Carcinoma 0.0215 0.0109 1.1e-04 0.013 0.012 0.011 NA 0.014 7.4e-04 1.1e-03 1.6e-03 NA 6.2e-04
4 TCGA Kidney Renal Clear Cell Carcinoma 0.2574 0.0803 5.5e-09 0.094 0.085 0.095 NA 0.087 9.0e-11 8.0e-10 8.4e-11 NA 5.4e-10
5 TCGA Prostate Adenocarcinoma 0.0661 0.0343 1.5e-04 0.009 0.029 0.019 NA 0.017 3.4e-02 4.3e-04 3.9e-03 NA 5.9e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.2 0.3 0.5 0.3 0.5 -0.5 0.7 -0.3
Bipolar Disorder or Schizophrenia 0.3 0.8 2.7 -0.3 1.6 -0.3 0.2 -0.9
Depressed Affect (Nagel 2018) 0.2 0.3 0.8 -0.3 -0.5 -0.9 -0.8 -0.0
Depression (Nagel 2018) 0.6 0.9 2.8 0.2 -0.9 -1.7 -0.0 -0.9
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.9 0.1 -0.0 -1.4 -1.0 -0.4
Neuroticism (Nagel 2018) 0.0 0.1 0.1 0.0 -0.4 -0.2 -0.3 0.1
Schizophrenia (2018) 0.4 0.9 2.9 -0.7 1.7 0.0 -0.3 -0.9
Schizophrenia vs Biploar Disorder 0.6 0.8 2.3 -0.7 -0.3 1.5 0.9 0.7
Worry (Nagel 2018) 0.1 0.2 0.6 0.3 -0.2 -0.8 -0.3 -0.5
Alzheimer’s Disease (in mother) 0.7 0.8 1.8 -1.3 -0.0 -1.1 0.2 -1.0
Alzheimer’s Disease (in father) 1.1 1.2 2.2 0.8 1.2 -1.0 -1.5 -0.9
Alzheimer’s Disease (including proxy) 1.1 1.6 3.8 -0.5 0.6 -1.9 -1.0 -1.6
Crohns Disease (2017) 0.1 0.3 0.7 0.8 0.3 0.7 0.2 -0.5
Irritable Bowel Disease (IBD) 0.1 0.3 0.5 0.7 0.2 0.5 0.2 -0.7
Ulcerative Colitis (UC) 0.1 0.2 0.4 0.6 0.5 0.3 -0.5 -0.4
Major Depression (MDD) 1.0 1.2 2.9 0.6 1.7 -0.5 0.4 -1.4
Reaction Time 0.3 0.5 0.8 -0.6 0.2 -0.8 -0.9 -0.8
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.6 0.4 -0.8 -1.3 -0.5 0.2
Breast Cancer 0.1 0.4 0.9 -0.8 0.2 0.9 -0.3 0.5
Ovarian Cancer 0.7 1.0 2.5 0.4 1.4 1.6 0.2 0.0
Prostate Cancer 0.2 0.3 0.9 -0.1 1.0 -0.6 -0.2 -0.3
Age at First Birth 0.1 0.2 0.7 0.5 0.8 -0.2 -0.0 0.1
Bipolar Disorder (2011) 0.4 0.4 1.0 0.0 -0.3 -1.0 0.0 -1.0
Body Mass Index (BMI) (2010) 0.6 0.8 1.0 1.0 -0.9 0.4 -1.0 1.0
Coronary Artery Disease (CAD) 1.9 2.3 4.4 -1.2 1.2 -1.6 -2.1 -1.3
Crohns Disease (2012) 0.5 0.7 2.5 -0.5 -0.4 1.6 0.8 0.1
Mean Putamen Volume 1.1 1.2 2.3 0.9 -1.0 -1.5 0.1 -1.4
Fasting Glucose 3.6 4.3 9.3 0.6 3.1 -0.8 -2.4 -2.4
HbA1C 0.5 0.5 1.6 -0.7 1.3 -0.4 0.0 -0.7
HDL Cholesterol 1.0 1.7 3.6 1.7 -0.9 -0.2 1.9 -1.0
LDL Cholesterol 2.2 3.4 14.6 0.2 0.8 -3.8 -1.2 0.5
Lupus 0.8 1.2 2.7 -1.5 -0.3 0.3 1.6 -0.9
Neuroticism (2016) 0.4 0.5 1.4 0.9 1.2 0.2 -0.3 -0.5
Primary Biliary Cirrhosis 1.5 2.1 4.2 1.1 -1.8 1.3 0.4 2.1
Rheumatoid Arthritis 0.4 0.6 1.8 -0.9 0.5 1.3 0.2 -0.3
Schizophrenia (2014) 0.4 0.9 2.0 -0.3 1.4 -0.8 -0.1 -1.3
Triglycerides 0.7 1.2 3.5 -0.5 0.3 -1.9 -0.7 1.3
Type 2 Diabetes (T2D) (2012) 1.2 1.3 2.4 0.3 -1.0 1.5 1.5 0.9
Ulcerative Colitis 0.2 0.3 0.8 -0.7 -0.2 0.9 0.6 -0.2
Blood Eosinophil Count 0.2 1.7 6.2 2.5 -0.3 0.0 0.8 1.2
Blood Platelet Count 0.8 9.8 25.5 4.1 -1.2 5.0 1.9 1.3
Blood Red Count 0.4 3.7 8.9 -1.9 -2.0 -3.0 1.3 0.4
Blood White Count 1.5 11.3 22.8 -3.5 -3.3 4.8 1.8 2.7
Heel T-Score 0.1 1.0 3.2 -0.7 1.8 1.0 -0.3 0.4
BMI 0.2 1.3 2.4 0.9 1.2 1.6 1.4 -0.1
Height 0.2 3.5 11.5 -3.4 1.1 -0.2 2.2 -0.4
Waist Hip Ratio (WHR) 0.2 1.0 3.5 -1.1 -0.5 1.9 0.2 0.5
Systolic Blood Pressure 0.1 0.6 2.0 -0.6 -1.4 -0.8 -0.2 0.4
Smoking Status 0.8 1.9 3.8 0.9 -1.6 1.5 0.2 2.0
Allergy or Eczema 0.8 2.0 4.5 2.1 0.8 1.4 -1.1 1.2
Cardiovascular Disease 1.3 4.3 8.1 -2.0 -2.9 -1.3 1.5 2.3
Hypothyroidism (self reported) 3.8 8.7 18.6 -0.1 -3.3 3.1 2.1 4.3
Respiratory disease 0.3 0.6 1.1 0.8 0.4 -0.7 -0.8 -1.0
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.2 -1.5 -0.7 1.0 0.5 0.3
Lung FEV1/FVC ratio 1.2 5.9 18.1 4.2 1.6 -1.6 1.9 -1.6
Lung FVC 0.3 1.4 2.7 1.6 0.2 -1.6 -1.3 -0.1
Neuroticism 0.3 0.8 2.6 -0.5 -0.0 -1.6 -0.5 -0.9
Chronotype (morning person) 0.9 2.0 3.3 0.9 -1.6 1.4 1.8 1.3
Hair Pigment 0.1 1.5 3.1 1.8 -1.4 -0.3 1.5 -0.2
Tanning 0.0 0.4 1.2 0.1 0.5 1.1 -0.7 0.3
Hand grip strength (left) 0.5 1.2 1.9 -1.3 -1.4 0.2 1.1 1.1
Number of treatments/medications taken 2.3 4.1 12.8 0.5 -1.3 2.3 0.3 3.6
Average weekly spirits intake 0.5 0.6 2.5 1.6 -0.5 0.2 0.4 -0.2
Sensitivity / hurt feelings 0.2 0.3 0.7 -0.7 -0.2 0.3 0.8 0.6
Frequency of depressed mood in last 2 weeks 0.9 1.2 3.4 0.3 -0.4 -1.8 0.8 -1.3
Hearing difficulty/problems: Yes 0.7 1.0 3.0 -1.7 -0.5 1.0 0.9 0.0
Relative age of first facial hair 0.9 1.9 5.4 1.7 -1.0 -0.5 2.3 -0.3
Other serious medical condition/disability diagnosed by doctor 3.7 4.7 8.8 1.4 -1.6 2.8 1.6 3.0
Ever used hormone-replacement therapy (HRT) 1.8 2.3 5.0 -1.4 -0.5 2.0 0.3 2.2
Ever had hysterectomy (womb removed) 0.2 0.3 0.8 0.9 -0.2 -0.1 -0.7 0.3
Systolic blood pressure, automated reading 0.1 0.3 0.5 0.7 -0.3 -0.7 -0.7 -0.2
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 0.8 0.5 0.9 0.7 -0.8 -0.8
Angina 0.1 0.1 0.3 -0.5 -0.1 -0.2 -0.4 0.1
Medication for hormone replacement therapy 0.4 0.5 0.8 -0.6 -0.9 -0.7 -0.1 0.9
Vitamin and mineral supplements 1.3 1.8 5.2 -0.5 2.3 1.7 -0.5 -0.5
Supplements: Zinc 0.4 0.5 1.5 0.7 -0.4 -1.2 0.1 -0.5
Medication: Co-codamol 0.1 0.1 0.2 0.3 -0.1 -0.5 -0.3 -0.3
Medication: Metformin 0.2 0.3 0.6 -0.7 0.7 0.3 -0.2 -0.3
Diabetes (father) 0.4 0.5 1.8 -0.1 -0.2 1.3 0.8 0.3
Diabetes (mother) 0.1 0.1 0.2 -0.4 -0.4 -0.1 0.3 -0.1
Severe depression (siblings) 1.2 1.3 1.8 -1.2 0.3 -1.3 1.3 -1.3
Pack years adult smoking proportion 0.3 0.5 2.3 -1.5 -0.2 -0.3 0.4 0.0
Impedance of leg (right) 0.2 0.9 1.6 0.8 -1.2 -0.6 -0.7 -1.2
Leg fat-free mass (left) 0.5 2.7 6.1 -2.0 2.5 0.8 1.6 -0.2
Trunk fat percentage 0.5 2.2 6.2 1.1 1.2 2.5 1.4 0.4
Hand grip strength (right) 0.1 0.2 0.6 -0.8 -0.5 0.2 -0.1 0.3
Townsend deprivation index at recruitment 0.9 1.3 4.0 -1.4 -0.8 0.0 2.0 0.2
Current tobacco smoking 0.7 1.2 2.5 1.1 -1.0 1.6 1.1 0.2
Average weekly fortified wine intake 0.6 0.7 2.2 -1.5 0.9 -0.3 -0.7 -0.2
Maternal smoking around birth 0.3 0.5 0.9 0.6 0.1 0.9 0.5 0.9
Fed-up feelings 0.2 0.4 0.9 0.5 -0.8 -0.1 -0.9 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 4.3 -0.0 -2.1 -0.6 0.2 0.3
Relative age voice broke 1.1 1.7 4.4 2.1 -1.1 1.2 0.6 1.1
Taking other prescription medications 0.3 0.4 1.4 0.7 -0.2 0.4 -0.2 1.2
Age when periods started (menarche) 1.3 3.1 9.9 3.1 -0.6 1.3 1.6 0.7
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.6 -1.0 0.3 -0.2 -1.6 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 3.1 -0.4 1.8 0.1 -0.4 -0.4
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 1.7 -1.3 -0.8 -0.1 0.4 0.5
Qualifications: CSEs or equivalent 0.7 0.9 3.4 0.5 -0.2 -0.3 -0.7 -1.9
Serious illness, injury or assault to yourself 2.0 2.4 3.7 -1.6 -1.6 1.3 1.9 1.1
High blood pressure 0.5 1.4 3.2 -1.0 -1.8 -0.3 0.7 1.5
Hayfever, allergic rhinitis or eczema 0.7 1.4 2.0 1.3 -0.1 1.4 -1.2 1.4
Multivitamins +/- minerals 1.0 1.3 3.5 -0.2 -1.9 -1.5 0.8 -0.1
Stomach or abdominal pain in last month 0.7 0.9 3.8 1.9 0.2 0.4 0.5 -0.2
Supplements: Glucosamine 0.2 0.3 0.8 0.9 0.1 0.1 -0.8 -0.1
Diverticular disease/diverticulitis (self-reported) 2.1 2.5 10.8 3.3 0.3 -0.9 0.5 -0.8
Medication: Atenolol 1.2 1.5 3.8 -1.3 0.4 -1.1 1.9 -0.9
Medication: Levothyroxine sodium 4.5 7.6 16.7 0.4 -2.2 3.6 1.8 4.1
Sitting height 0.6 4.2 18.7 -4.3 1.4 -0.0 -0.0 -0.0
Chronic bronchitis/emphysema (father) 1.1 1.2 5.7 -0.7 -0.3 -0.1 2.4 -0.2
High blood pressure (mother) 0.8 1.1 2.3 -1.1 -1.5 -0.1 1.0 1.0
Body mass index (BMI) 0.3 1.3 3.2 0.8 1.8 1.4 0.9 -0.1
Impedance of leg (left) 0.2 0.8 1.4 1.0 -1.2 -0.2 -1.0 -0.7
Leg predicted mass (left) 0.5 2.7 6.0 -2.0 2.4 0.8 1.7 -0.2
Trunk fat mass 0.4 1.9 4.5 0.3 2.1 1.9 1.1 -0.1
Waist circumference 0.4 1.5 3.8 -0.8 1.9 1.6 0.7 0.1
Number of incorrect matches in round 0.2 0.4 1.0 0.6 1.0 0.3 -0.1 -0.7
Past tobacco smoking 1.3 2.4 6.3 0.7 0.6 -2.1 0.6 -2.5
Alcohol usually taken with meals 0.9 1.5 3.1 0.8 0.8 -1.8 -1.6 -0.7
Nervous feelings 0.7 1.3 2.5 0.4 -0.1 -1.6 -1.5 -1.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.3 0.2 -1.1 -1.1 -0.1 0.1
Hearing difficulty/problems with background noise 0.6 1.0 3.8 -1.9 0.3 -0.0 -1.0 -0.3
Hair/balding pattern: Pattern 2 0.2 0.2 0.7 -0.2 0.6 0.1 0.8 -0.1
Had menopause 0.2 0.2 0.6 0.5 0.4 -0.8 0.3 0.1
Had other major operations 0.6 0.7 3.3 -1.8 -0.3 0.4 0.1 -0.0
Forced vital capacity (FVC) 0.2 0.6 1.3 0.7 1.1 -1.1 -0.2 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.2 -1.1 0.7 0.1 -0.4 0.8
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 3.1 1.1 -1.5 1.2 -0.1 1.8
Qualifications: None of the above 0.4 0.9 3.2 -0.5 -0.8 0.5 1.8 0.6
Financial difficulties in last 2 years 0.3 0.5 0.8 0.3 -0.9 0.9 0.7 0.3
Mouth/teeth dental problems 0.1 0.2 0.3 -0.4 -0.5 -0.3 -0.5 0.5
Heart attack 0.2 0.2 0.5 0.6 -0.3 -0.1 -0.5 0.7
Allergy 0.6 1.4 3.2 -0.6 0.3 -1.3 1.8 -1.4
Pain all over the body in last month 0.1 0.1 0.3 0.1 0.3 0.5 -0.5 -0.3
Diabetes (self-reported) 0.2 0.3 0.8 -0.9 -0.4 0.6 0.1 0.0
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.5 0.7 -0.6 1.2 0.5 1.1
Medication: Ramipril 0.5 0.7 1.9 -1.4 0.7 0.4 -0.8 0.5
Medication: Simvastatin 1.1 1.5 3.3 -1.2 -1.4 -1.8 0.4 1.0
Fluid intelligence score 0.2 0.4 0.9 0.8 -0.3 -0.2 -1.0 0.5
Illnesses of siblings 0.7 1.0 3.0 0.1 -0.9 1.7 0.3 1.1
Neuroticism score 0.3 0.7 2.0 -0.4 -0.2 -1.4 -0.4 -1.0
Weight 0.4 2.1 7.6 -0.9 2.8 0.8 1.0 -0.7
Impedance of arm (right) 0.2 0.9 1.7 1.3 -0.9 1.1 -0.9 0.4
Arm fat percentage (right) 0.5 1.8 4.3 1.4 1.7 2.1 0.3 0.3
Trunk fat-free mass 0.6 3.6 9.2 -2.6 3.0 -0.7 0.4 -1.2
Hip circumference 0.3 1.2 3.4 -1.1 1.9 0.7 0.9 0.2
Time employed in main current job 0.8 1.0 2.3 1.0 1.1 1.5 0.3 -0.3
Alcohol intake versus 10 years previously 0.3 0.5 1.0 -0.5 -0.6 -1.0 0.7 -0.6
Father’s age at death 1.8 2.4 5.2 0.4 2.3 -0.7 -2.0 -1.5
Worrier / anxious feelings 0.1 0.2 0.6 -0.1 0.3 -0.2 -0.4 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 2.2 0.0 -0.3 -0.2 -1.5 0.4
Falls in the last year 0.2 0.2 0.5 -0.6 0.0 0.4 0.7 0.1
Hair/balding pattern: Pattern 3 0.6 0.9 1.9 0.8 0.8 1.4 -1.2 0.1
Number of live births 0.6 0.9 2.0 -1.1 -0.0 1.4 0.0 1.2
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 2.5 1.6 1.5 -1.1 0.4 -0.5
Pulse rate 1.2 2.1 3.5 -1.2 -1.6 1.9 0.8 1.5
Happiness 0.3 0.3 0.5 0.6 0.5 -0.5 -0.7 -0.4
Noisy workplace 1.4 1.7 4.5 0.3 0.5 -1.9 -0.4 -2.1
Qualifications: A levels/AS levels or equivalent 0.5 1.0 1.6 -0.5 1.1 -0.8 -1.3 -1.2
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.3 -0.8 -0.0 1.2 0.1 0.7
Mouth/teeth dental problems: Dentures 1.4 2.3 5.4 0.8 -0.9 2.0 0.8 2.3
Asthma 0.3 0.6 2.6 -0.1 -0.7 -0.2 -1.6 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.9 -0.1 0.1 0.4 0.9 -0.3
Medication: Cholesterol lowering 0.5 0.7 2.0 -0.3 -0.8 -1.4 0.4 0.9
Depression (self-reported) 0.7 0.9 3.2 -0.1 0.4 -1.0 1.8 -0.2
Medication: Lansoprazole 1.1 1.2 3.1 1.2 0.5 1.8 0.5 1.0
Prospective memory result 0.1 0.1 0.2 0.5 0.4 -0.1 0.5 -0.1
Lung cancer (father) 0.7 0.8 1.4 -1.0 -1.0 0.6 -0.8 1.2
Illnesses of mother 0.2 0.3 0.6 0.7 0.2 0.7 0.4 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 1.8 1.2 1.4 -0.9 0.4 -0.6
Pulse wave Arterial Stiffness index 1.0 1.2 4.3 -0.2 0.5 -2.1 -1.1 -0.6
Impedance of arm (left) 0.3 1.5 2.4 1.0 -1.4 1.5 -0.7 1.2
Arm fat mass (right) 0.4 1.7 4.7 0.2 2.2 1.8 0.8 -0.1
Trunk predicted mass 0.6 3.6 9.0 -2.6 3.0 -0.7 0.4 -1.2
Standing height 0.4 4.3 13.1 -3.6 2.3 -1.0 0.5 -1.4
Length of working week for main job 0.6 0.7 3.0 0.2 0.2 0.5 1.7 0.2
Exposure to tobacco smoke at home 0.2 0.3 1.0 -1.0 -0.3 -0.1 -0.3 -0.4
Breastfed as a baby 1.4 1.8 3.0 1.7 1.2 -1.5 -0.2 -1.3
Tense / ‘highly strung’ 0.7 1.1 4.4 -0.2 0.5 -0.9 -0.5 -2.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.3 -0.3 0.5 0.7 -1.1 0.4
Hair/balding pattern: Pattern 4 0.1 0.2 0.3 0.1 0.5 0.6 -0.5 0.3
Birth weight of first child 1.6 2.9 4.0 -2.0 1.5 -1.6 -1.5 -1.8
Peak expiratory flow (PEF) 0.2 0.4 1.3 -0.3 1.1 -0.2 0.8 -0.1
Pulse wave reflection index 2.9 3.6 5.7 1.2 2.4 -1.9 -1.3 -2.3
Ever highly irritable/argumentative for 2 days 0.9 1.1 3.0 -1.7 0.1 1.3 -0.7 0.4
Loud music exposure frequency 0.7 0.7 1.7 0.6 -0.3 1.1 -1.3 0.6
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 4.2 -0.1 1.1 -0.9 -1.0 -2.0
Mouth/teeth dental problems: Bleeding gums 0.0 0.0 0.1 -0.2 -0.2 0.3 -0.3 -0.0
Blood clot in the leg (DVT) 1.4 1.8 3.1 -1.8 -1.1 1.1 0.8 1.6
Medication: Paracetamol 0.6 0.9 2.5 0.7 -0.3 1.2 1.6 0.3
Headache pain in last month 0.6 1.0 2.5 -1.3 0.6 -0.3 1.6 -0.7
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 2.4 1.5 1.2 0.5 -1.6 -0.9
Glaucoma (self-reported) 0.8 1.0 3.4 0.1 0.1 -1.1 -1.8 -0.4
Gout (self-reported) 0.2 0.3 0.9 -0.2 -0.5 0.5 0.3 1.0
Hypothyroidism/myxoedema (self-reported) 3.5 6.9 16.0 0.7 -2.6 2.8 1.8 4.0
Medication: Amlodipine 2.9 4.0 11.7 -0.8 -3.4 0.8 1.6 2.1
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.1 -0.8 0.9 -0.5 -1.4 -0.6
Birth weight 0.2 0.4 0.6 -0.4 0.8 -0.8 -0.6 -0.7
Chronic bronchitis/emphysema (mother) 2.0 2.4 6.2 0.1 2.5 -0.7 -1.5 -1.7
High blood pressure (siblings) 0.1 0.1 0.2 -0.4 0.3 0.4 -0.0 0.4
Forced vital capacity (FVC), Best measure 0.1 0.5 1.9 -0.1 1.4 -0.6 -0.1 -0.5
Body fat percentage 0.3 1.4 3.4 1.1 1.2 1.9 0.8 0.1
Leg fat percentage (right) 0.4 1.4 2.8 1.7 1.5 0.1 0.7 -1.2
Arm fat-free mass (right) 0.5 2.6 6.5 -2.0 2.5 -0.3 1.1 -1.0
Exposure to tobacco smoke outside home 0.9 1.3 3.1 -1.8 -0.2 -1.4 -0.6 -0.8
Comparative body size at age 10 1.3 3.6 7.0 2.7 2.2 -1.8 -1.3 -1.1
Number of full brothers 0.9 1.1 2.8 0.3 0.1 1.5 1.7 0.6
Worry too long after embarrassment 0.4 0.6 1.9 -1.4 -0.7 0.5 0.5 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.3 -0.3 -0.1 -0.8 -1.5 -0.9
Wheeze or whistling in the chest in last year 0.2 0.4 1.2 0.5 -0.1 -0.5 0.1 -1.1
Number of children fathered 1.2 1.4 3.3 1.6 0.8 1.8 -0.7 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.5 -0.2 -1.6 -1.2 -0.3 0.3
Age at first live birth 1.6 2.9 6.4 -1.2 0.7 -1.9 -2.5 -1.5
Pulse wave peak to peak time 1.1 1.3 4.6 -0.2 -0.5 2.2 1.1 0.5
Health satisfaction 0.7 0.9 1.5 1.2 -1.1 0.0 -0.9 1.1
Shortness of breath walking on level ground 0.3 0.3 0.8 0.3 0.8 0.1 -0.9 -0.1
Qualifications: College or University degree 0.3 0.9 2.8 0.2 -0.8 0.6 0.6 1.7
Eye problems/disorders: None of the above 0.3 0.3 0.6 -0.4 -0.8 -0.6 0.3 0.6
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.7 0.6 0.8 -0.2 -1.3 -0.2
Emphysema/chronic bronchitis 1.7 1.9 3.4 1.1 1.3 -1.8 0.3 -1.8
Medication for pain relief, constipation, heartburn 0.9 1.5 4.0 -0.7 -0.1 -2.0 -0.6 -1.6
Neck or shoulder pain in last month 1.1 1.5 4.6 0.4 -1.2 2.1 0.8 0.8
Medication: Blood pressure 0.9 1.6 3.3 -1.8 -1.2 0.7 1.1 1.3
Angina (self-reported) 0.1 0.1 0.2 -0.4 -0.0 -0.4 -0.1 0.0
Migraine (self-reported) 0.1 0.1 0.4 -0.6 0.1 0.1 -0.3 0.2
Medication: Ibuprofen 0.2 0.2 0.5 -0.0 0.5 0.6 0.7 -0.3
Medication: Allopurinol 0.3 0.4 1.4 0.3 0.7 -0.4 -1.2 0.1
Medication: Omeprazole 3.4 4.0 11.2 1.2 -0.5 3.3 1.2 2.4
Medication: Seretide 50 evohaler 0.7 0.9 3.3 -0.4 -0.1 -0.0 -1.8 0.9
Mean time to correctly identify matches 0.9 1.8 3.7 -0.9 0.8 -1.9 -1.3 -1.4
Heart disease (mother) 0.5 0.6 1.6 -0.2 -1.0 0.2 0.6 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 2.5 1.6 0.2 -1.4 -0.8 -0.8
Whole body fat mass 0.4 1.7 4.6 0.1 2.2 1.7 0.9 -0.2
Leg fat mass (right) 0.3 1.3 4.7 0.4 2.2 0.5 0.8 -1.0
Arm predicted mass (right) 0.6 3.0 6.3 -2.4 2.5 -0.5 1.2 -1.0
Pulse rate, automated reading 1.3 4.1 11.3 -0.4 -1.5 3.4 1.1 2.3
Alcohol intake frequency. 0.8 1.8 5.4 -0.2 0.7 -1.7 -0.0 -2.3
Comparative height size at age 10 1.5 8.3 36.4 -6.0 0.3 -1.8 0.8 -1.1
Number of full sisters 0.4 0.5 1.5 -1.2 0.9 -0.1 0.5 -0.2
Suffer from ‘nerves’ 0.5 0.8 2.1 0.9 -0.9 -1.4 0.1 0.0
Overall health rating 0.3 0.6 1.0 -0.6 -0.9 1.0 0.4 0.7
Chest pain or discomfort 0.2 0.3 0.9 -0.9 0.7 0.5 -0.1 -0.1
Had major operations 0.6 0.7 1.8 -0.4 -0.5 1.0 1.3 0.6
Age at last live birth 1.0 1.4 4.7 -1.0 0.3 -1.1 -2.2 0.3
Family relationship satisfaction 1.8 2.2 5.4 0.2 1.4 2.3 -1.1 1.5
Leg pain on walking 0.3 0.3 0.5 0.2 -0.7 -0.7 -0.7 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.7 0.9 -0.1 -0.5 0.1 -1.3
Commuting to job workplace: Car/motor vehicle 0.3 0.4 1.3 0.0 0.0 -0.1 -0.7 -1.1
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.6 0.5 0.8 -0.2 0.3 -0.5
Medication: Aspirin 0.7 1.0 3.5 0.3 -0.6 0.5 0.8 1.9
Supplements: Vitamin C 1.2 1.5 2.8 1.2 -1.7 -0.1 1.3 1.2
Knee pain experienced in last month 2.2 3.4 9.1 -1.4 -1.0 2.1 3.0 0.9
Hypertension (Self-reported) 0.6 1.6 4.4 -0.9 -2.1 -0.7 0.5 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.1 0.7 0.2 1.1 0.1 0.9
Illnesses of father: Heart disease 1.7 2.4 8.3 0.1 -0.9 0.5 2.9 1.6
Illnesses of siblings: Diabetes 0.3 0.4 1.0 -0.7 -0.5 -0.1 -1.0 -0.4
Smoking status: Previous 1.4 2.0 5.8 -1.0 -0.0 1.7 -0.6 2.4
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 5.0 -0.6 1.6 -0.4 0.8 -2.2
Whole body fat-free mass 0.5 3.1 7.9 -2.4 2.8 0.0 1.1 -0.8
Leg fat-free mass (right) 0.5 2.5 5.6 -2.0 2.4 0.9 1.4 0.1
Arm fat percentage (left) 0.6 2.2 5.8 1.6 1.5 2.4 0.5 0.6
Average weekly red wine intake 0.5 0.8 3.0 1.7 -0.1 -0.7 -0.5 0.6
Handedness (chirality/laterality): Left-handed 3.7 4.4 10.8 -1.2 1.4 -3.3 -0.2 -2.8
Mood swings 0.3 0.5 1.2 0.4 0.1 -1.1 -0.8 -0.8
Loneliness, isolation 0.2 0.3 1.3 1.1 0.6 0.1 0.0 0.0
Long-standing illness, disability or infirmity 1.4 2.1 5.8 -0.9 -0.7 2.4 1.1 1.6
Ever had bowel cancer screening 1.3 1.6 3.8 0.5 0.8 -1.8 -0.2 -1.9
Diabetes diagnosed by doctor 0.2 0.3 0.8 -0.8 -0.1 0.9 0.0 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 3.3 -1.8 0.4 0.3 -0.2 -0.2
Friendships satisfaction 1.1 1.3 3.0 -1.1 -0.6 1.7 0.3 1.4
Qualifications: nursing, teaching 0.4 0.6 1.3 -1.1 0.6 0.6 0.9 0.4
Commuting to job workplace: Walk 0.6 0.6 1.3 1.2 -0.1 0.8 0.4 1.0
Eye problems/disorders: Cataract 0.9 1.0 2.7 -0.6 -0.8 1.7 0.6 1.0
Mouth/teeth dental problems: Mouth ulcers 1.7 2.7 5.6 -0.1 1.4 -1.7 -1.7 -2.4
Medication for cholesterol 0.7 1.1 2.2 -0.1 1.2 1.5 -0.7 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.2 2.8 -1.5 -0.9 -0.7 -1.7 0.0
Back pain experienced in last month 1.2 1.8 6.4 -2.5 -1.1 -0.7 0.9 0.2
Mineral and other dietary supplements 0.6 0.9 2.8 -0.3 1.7 0.6 -0.4 -0.9
Breast cancer (self-reported) 1.0 1.2 2.7 -1.6 0.1 -1.6 0.8 -0.3
Asthma (self-reported) 0.2 0.5 1.7 -0.1 -0.8 -0.2 -1.3 -0.1
Osteoporosis (self-reported) 0.9 1.1 2.2 -1.5 -0.7 1.3 0.5 0.9
Osteoarthritis (self-reported) 0.6 0.7 1.7 1.3 0.9 -0.0 0.8 -0.6
Medication: Aspirin 0.5 0.6 1.8 0.1 -0.5 0.3 0.9 1.4
Medication: Gliclazide 0.5 0.6 1.3 -0.8 1.2 0.9 -0.0 -0.4
Illnesses of father: None of the above (group 1) 0.5 0.6 2.0 -0.2 -0.1 -0.5 -1.4 -0.8
Smoking status: Current 0.6 0.9 1.3 1.1 -1.0 1.2 1.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.5 6.2 2.1 0.6 -2.5 0.8 -0.8
Whole body water mass 0.5 3.1 8.5 -2.3 2.9 -0.1 1.0 -0.8
Leg predicted mass (right) 0.5 2.6 6.2 -2.0 2.5 0.8 1.5 0.0
Arm fat mass (left) 0.4 1.7 4.2 0.4 2.1 1.9 0.9 0.1
Number of self-reported non-cancer illnesses 1.7 2.9 6.0 -0.6 -2.5 1.0 1.1 2.4
Average weekly champagne plus white wine intake 0.9 1.2 3.0 -1.7 0.1 0.3 -1.7 0.3
Miserableness 0.1 0.2 0.4 0.0 -0.3 -0.7 -0.4 -0.6
Guilty feelings 0.2 0.3 1.1 -1.0 0.4 0.4 -0.0 -0.4
Wears glasses or contact lenses 2.2 2.5 8.9 0.8 1.4 -0.3 -3.0 1.0
Ever taken oral contraceptive pill 1.3 1.4 3.1 0.5 0.9 -1.8 0.5 -1.7
Hearing aid user 0.4 0.5 1.7 1.3 -0.5 -0.3 0.4 0.4
Mother’s age at death 0.8 1.1 4.0 2.0 0.4 -0.9 0.1 -0.6
Financial situation satisfaction 0.7 0.9 3.1 -0.8 0.1 0.7 -1.8 0.2
Tinnitus: Yes, now most or all of the time 0.7 0.9 2.1 -0.8 -0.9 -0.8 1.5 -0.1
Commuting to job workplace: Public transport 0.2 0.3 0.6 -0.6 0.3 -0.6 -0.1 0.8
Eye problems/disorders: Glaucoma 1.3 1.6 3.3 0.5 0.4 -1.8 -1.5 -1.5
Medication: Blood pressure 0.3 0.6 1.8 0.6 -0.9 0.2 0.3 1.3
Pain type(s) experienced in last month: Hip pain 0.8 1.0 4.0 -0.2 -0.8 0.2 2.0 -0.0
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.3 -0.4 -0.0 -0.3 -0.3 0.5
High cholesterol (Self-reported) 1.8 3.2 12.0 -0.5 -1.3 -3.5 0.9 1.1
Medication: Bendroflumethiazide 0.7 1.0 2.0 -1.4 -1.4 -0.6 0.9 0.1
Medication: Paracetamol 1.2 1.9 5.1 1.3 -0.6 1.4 2.3 0.9
Medication: Lisinopril 2.2 2.9 6.1 -1.5 -2.5 0.5 1.4 1.9
Medication: Atorvastatin 0.6 0.7 2.0 0.3 -0.1 -0.6 1.0 1.4
Illnesses of father: High blood pressure 1.0 1.2 2.3 0.8 -0.7 1.5 0.8 1.4
Alcohol drinker status: Never 0.4 0.5 1.0 0.9 -0.8 -0.1 -0.2 1.0
Ever smoked 1.5 2.6 6.7 -0.3 -1.2 2.0 -0.7 2.6
Basal metabolic rate 0.5 2.8 7.5 -2.1 2.7 0.3 1.2 -0.6
Leg fat percentage (left) 0.3 1.2 2.6 1.6 1.5 0.4 0.5 -0.8
Arm fat-free mass (left) 0.7 3.5 8.3 -2.5 2.9 -0.4 1.1 -1.2
Number of operations (self-reported) 0.6 0.8 2.9 -1.7 0.8 0.8 -0.1 0.2
Average weekly beer plus cider intake 1.1 1.6 4.9 -0.8 0.8 2.2 -0.8 1.0
Irritability 0.9 1.5 2.8 -0.3 -1.2 1.7 0.4 1.6
Risk taking 0.3 0.5 1.0 0.6 -0.4 1.0 0.3 0.9
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.2 -0.0 0.4 -1.1 0.3 -0.9
Fractured/broken bones in last 5 years 0.4 0.6 2.1 -0.5 -0.1 1.5 -0.4 0.5
Age started oral contraceptive pill 1.2 1.5 3.0 -0.3 1.3 -1.7 -0.5 -1.6
Diastolic blood pressure, automated reading 0.4 1.3 3.5 -0.6 -0.5 1.9 1.1 1.0
Ever depressed for a whole week 0.6 0.8 1.8 0.0 -0.4 1.3 -0.5 1.3
Unable to work because of sickness or disability 0.3 0.4 1.0 -1.0 -0.6 0.2 -0.6 0.4
Commuting to job workplace: Cycle 0.6 0.7 2.7 0.7 1.7 -0.3 -0.2 -0.3
Myopia 1.9 2.8 6.2 0.5 2.5 -1.0 -2.3 -1.2
Vascular/heart problems diagnosed by doctor 0.5 1.4 3.0 1.4 1.7 0.5 -0.7 -1.2
Cholesterol lowering medication 1.1 1.7 4.4 -0.5 -0.9 -1.2 1.2 2.1
Medication: Omeprazole (e.g. Zanprol) 2.7 3.2 7.2 1.8 -0.6 2.7 0.6 2.3
Pain experienced in last month 0.4 0.6 1.5 1.2 0.2 -0.4 -1.1 0.5
Supplements: Calcium 0.1 0.2 0.6 -0.8 0.2 -0.3 0.1 0.2
Basal cell carcinoma (self-reported) 0.5 0.6 1.6 -0.5 1.2 -0.4 -0.5 -0.9
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.4 0.6 -0.2 -0.1 -0.4 0.5
Deep venous thrombosis (DVT) (self-reported) 1.3 1.6 3.2 -1.8 -0.9 1.1 0.9 1.5
Heart disease (siblings) 2.2 2.7 6.4 -0.4 1.2 -2.5 0.2 -2.3
Alcohol drinker status: Previous 1.0 1.1 3.3 -0.4 0.5 -1.2 -1.8 -0.8
Pack years of smoking 0.4 0.6 2.5 -1.6 0.0 -0.6 0.1 -0.1
Impedance of whole body 0.2 0.9 2.7 1.0 -1.6 0.7 -0.7 0.4
Leg fat mass (left) 0.3 1.3 4.8 0.2 2.2 0.8 0.8 -0.7
Arm predicted mass (left) 0.6 2.9 6.6 -2.2 2.6 -0.4 1.3 -1.1