Hub : Genes

HAVCR2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue (Female)	0.1398	0.0646	1.1e-02	-0.003	NA	-0.003	NA	0.008	4.0e-01	NA	4.1e-01	NA	1.8e-01
2	GTEx	Testis	0.2760	0.0650	1.2e-06	0.158	NA	0.136	NA	0.131	1.7e-07	NA	1.3e-06	NA	2.1e-06
3	TCGA	Breast Invasive Carcinoma	0.0215	0.0109	1.1e-04	0.013	0.012	0.011	NA	0.014	7.4e-04	1.1e-03	1.6e-03	NA	6.2e-04
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.2574	0.0803	5.5e-09	0.094	0.085	0.095	NA	0.087	9.0e-11	8.0e-10	8.4e-11	NA	5.4e-10
5	TCGA	Prostate Adenocarcinoma	0.0661	0.0343	1.5e-04	0.009	0.029	0.019	NA	0.017	3.4e-02	4.3e-04	3.9e-03	NA	5.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	0.5	0.3	0.5	-0.5	0.7	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.8	2.7	-0.3	1.6	-0.3	0.2	-0.9
Depressed Affect (Nagel 2018)	0.2	0.3	0.8	-0.3	-0.5	-0.9	-0.8	-0.0
Depression (Nagel 2018)	0.6	0.9	2.8	0.2	-0.9	-1.7	-0.0	-0.9
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.9	0.1	-0.0	-1.4	-1.0	-0.4
Neuroticism (Nagel 2018)	0.0	0.1	0.1	0.0	-0.4	-0.2	-0.3	0.1
Schizophrenia (2018)	0.4	0.9	2.9	-0.7	1.7	0.0	-0.3	-0.9
Schizophrenia vs Biploar Disorder	0.6	0.8	2.3	-0.7	-0.3	1.5	0.9	0.7
Worry (Nagel 2018)	0.1	0.2	0.6	0.3	-0.2	-0.8	-0.3	-0.5
Alzheimer’s Disease (in mother)	0.7	0.8	1.8	-1.3	-0.0	-1.1	0.2	-1.0
Alzheimer’s Disease (in father)	1.1	1.2	2.2	0.8	1.2	-1.0	-1.5	-0.9
Alzheimer’s Disease (including proxy)	1.1	1.6	3.8	-0.5	0.6	-1.9	-1.0	-1.6
Crohns Disease (2017)	0.1	0.3	0.7	0.8	0.3	0.7	0.2	-0.5
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	0.7	0.2	0.5	0.2	-0.7
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.6	0.5	0.3	-0.5	-0.4
Major Depression (MDD)	1.0	1.2	2.9	0.6	1.7	-0.5	0.4	-1.4
Reaction Time	0.3	0.5	0.8	-0.6	0.2	-0.8	-0.9	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.6	0.4	-0.8	-1.3	-0.5	0.2
Breast Cancer	0.1	0.4	0.9	-0.8	0.2	0.9	-0.3	0.5
Ovarian Cancer	0.7	1.0	2.5	0.4	1.4	1.6	0.2	0.0
Prostate Cancer	0.2	0.3	0.9	-0.1	1.0	-0.6	-0.2	-0.3
Age at First Birth	0.1	0.2	0.7	0.5	0.8	-0.2	-0.0	0.1
Bipolar Disorder (2011)	0.4	0.4	1.0	0.0	-0.3	-1.0	0.0	-1.0
Body Mass Index (BMI) (2010)	0.6	0.8	1.0	1.0	-0.9	0.4	-1.0	1.0
Coronary Artery Disease (CAD)	1.9	2.3	4.4	-1.2	1.2	-1.6	-2.1	-1.3
Crohns Disease (2012)	0.5	0.7	2.5	-0.5	-0.4	1.6	0.8	0.1
Mean Putamen Volume	1.1	1.2	2.3	0.9	-1.0	-1.5	0.1	-1.4
Fasting Glucose	3.6	4.3	9.3	0.6	3.1	-0.8	-2.4	-2.4
HbA1C	0.5	0.5	1.6	-0.7	1.3	-0.4	0.0	-0.7
HDL Cholesterol	1.0	1.7	3.6	1.7	-0.9	-0.2	1.9	-1.0
LDL Cholesterol	2.2	3.4	14.6	0.2	0.8	-3.8	-1.2	0.5
Lupus	0.8	1.2	2.7	-1.5	-0.3	0.3	1.6	-0.9
Neuroticism (2016)	0.4	0.5	1.4	0.9	1.2	0.2	-0.3	-0.5
Primary Biliary Cirrhosis	1.5	2.1	4.2	1.1	-1.8	1.3	0.4	2.1
Rheumatoid Arthritis	0.4	0.6	1.8	-0.9	0.5	1.3	0.2	-0.3
Schizophrenia (2014)	0.4	0.9	2.0	-0.3	1.4	-0.8	-0.1	-1.3
Triglycerides	0.7	1.2	3.5	-0.5	0.3	-1.9	-0.7	1.3
Type 2 Diabetes (T2D) (2012)	1.2	1.3	2.4	0.3	-1.0	1.5	1.5	0.9
Ulcerative Colitis	0.2	0.3	0.8	-0.7	-0.2	0.9	0.6	-0.2
Blood Eosinophil Count	0.2	1.7	6.2	2.5	-0.3	0.0	0.8	1.2
Blood Platelet Count	0.8	9.8	25.5	4.1	-1.2	5.0	1.9	1.3
Blood Red Count	0.4	3.7	8.9	-1.9	-2.0	-3.0	1.3	0.4
Blood White Count	1.5	11.3	22.8	-3.5	-3.3	4.8	1.8	2.7
Heel T-Score	0.1	1.0	3.2	-0.7	1.8	1.0	-0.3	0.4
BMI	0.2	1.3	2.4	0.9	1.2	1.6	1.4	-0.1
Height	0.2	3.5	11.5	-3.4	1.1	-0.2	2.2	-0.4
Waist Hip Ratio (WHR)	0.2	1.0	3.5	-1.1	-0.5	1.9	0.2	0.5
Systolic Blood Pressure	0.1	0.6	2.0	-0.6	-1.4	-0.8	-0.2	0.4
Smoking Status	0.8	1.9	3.8	0.9	-1.6	1.5	0.2	2.0
Allergy or Eczema	0.8	2.0	4.5	2.1	0.8	1.4	-1.1	1.2
Cardiovascular Disease	1.3	4.3	8.1	-2.0	-2.9	-1.3	1.5	2.3
Hypothyroidism (self reported)	3.8	8.7	18.6	-0.1	-3.3	3.1	2.1	4.3
Respiratory disease	0.3	0.6	1.1	0.8	0.4	-0.7	-0.8	-1.0
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.2	-1.5	-0.7	1.0	0.5	0.3
Lung FEV1/FVC ratio	1.2	5.9	18.1	4.2	1.6	-1.6	1.9	-1.6
Lung FVC	0.3	1.4	2.7	1.6	0.2	-1.6	-1.3	-0.1
Neuroticism	0.3	0.8	2.6	-0.5	-0.0	-1.6	-0.5	-0.9
Chronotype (morning person)	0.9	2.0	3.3	0.9	-1.6	1.4	1.8	1.3
Hair Pigment	0.1	1.5	3.1	1.8	-1.4	-0.3	1.5	-0.2
Tanning	0.0	0.4	1.2	0.1	0.5	1.1	-0.7	0.3
Hand grip strength (left)	0.5	1.2	1.9	-1.3	-1.4	0.2	1.1	1.1
Number of treatments/medications taken	2.3	4.1	12.8	0.5	-1.3	2.3	0.3	3.6
Average weekly spirits intake	0.5	0.6	2.5	1.6	-0.5	0.2	0.4	-0.2
Sensitivity / hurt feelings	0.2	0.3	0.7	-0.7	-0.2	0.3	0.8	0.6
Frequency of depressed mood in last 2 weeks	0.9	1.2	3.4	0.3	-0.4	-1.8	0.8	-1.3
Hearing difficulty/problems: Yes	0.7	1.0	3.0	-1.7	-0.5	1.0	0.9	0.0
Relative age of first facial hair	0.9	1.9	5.4	1.7	-1.0	-0.5	2.3	-0.3
Other serious medical condition/disability diagnosed by doctor	3.7	4.7	8.8	1.4	-1.6	2.8	1.6	3.0
Ever used hormone-replacement therapy (HRT)	1.8	2.3	5.0	-1.4	-0.5	2.0	0.3	2.2
Ever had hysterectomy (womb removed)	0.2	0.3	0.8	0.9	-0.2	-0.1	-0.7	0.3
Systolic blood pressure, automated reading	0.1	0.3	0.5	0.7	-0.3	-0.7	-0.7	-0.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	0.8	0.5	0.9	0.7	-0.8	-0.8
Angina	0.1	0.1	0.3	-0.5	-0.1	-0.2	-0.4	0.1
Medication for hormone replacement therapy	0.4	0.5	0.8	-0.6	-0.9	-0.7	-0.1	0.9
Vitamin and mineral supplements	1.3	1.8	5.2	-0.5	2.3	1.7	-0.5	-0.5
Supplements: Zinc	0.4	0.5	1.5	0.7	-0.4	-1.2	0.1	-0.5
Medication: Co-codamol	0.1	0.1	0.2	0.3	-0.1	-0.5	-0.3	-0.3
Medication: Metformin	0.2	0.3	0.6	-0.7	0.7	0.3	-0.2	-0.3
Diabetes (father)	0.4	0.5	1.8	-0.1	-0.2	1.3	0.8	0.3
Diabetes (mother)	0.1	0.1	0.2	-0.4	-0.4	-0.1	0.3	-0.1
Severe depression (siblings)	1.2	1.3	1.8	-1.2	0.3	-1.3	1.3	-1.3
Pack years adult smoking proportion	0.3	0.5	2.3	-1.5	-0.2	-0.3	0.4	0.0
Impedance of leg (right)	0.2	0.9	1.6	0.8	-1.2	-0.6	-0.7	-1.2
Leg fat-free mass (left)	0.5	2.7	6.1	-2.0	2.5	0.8	1.6	-0.2
Trunk fat percentage	0.5	2.2	6.2	1.1	1.2	2.5	1.4	0.4
Hand grip strength (right)	0.1	0.2	0.6	-0.8	-0.5	0.2	-0.1	0.3
Townsend deprivation index at recruitment	0.9	1.3	4.0	-1.4	-0.8	0.0	2.0	0.2
Current tobacco smoking	0.7	1.2	2.5	1.1	-1.0	1.6	1.1	0.2
Average weekly fortified wine intake	0.6	0.7	2.2	-1.5	0.9	-0.3	-0.7	-0.2
Maternal smoking around birth	0.3	0.5	0.9	0.6	0.1	0.9	0.5	0.9
Fed-up feelings	0.2	0.4	0.9	0.5	-0.8	-0.1	-0.9	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	4.3	-0.0	-2.1	-0.6	0.2	0.3
Relative age voice broke	1.1	1.7	4.4	2.1	-1.1	1.2	0.6	1.1
Taking other prescription medications	0.3	0.4	1.4	0.7	-0.2	0.4	-0.2	1.2
Age when periods started (menarche)	1.3	3.1	9.9	3.1	-0.6	1.3	1.6	0.7
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.6	-1.0	0.3	-0.2	-1.6	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	3.1	-0.4	1.8	0.1	-0.4	-0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.7	-1.3	-0.8	-0.1	0.4	0.5
Qualifications: CSEs or equivalent	0.7	0.9	3.4	0.5	-0.2	-0.3	-0.7	-1.9
Serious illness, injury or assault to yourself	2.0	2.4	3.7	-1.6	-1.6	1.3	1.9	1.1
High blood pressure	0.5	1.4	3.2	-1.0	-1.8	-0.3	0.7	1.5
Hayfever, allergic rhinitis or eczema	0.7	1.4	2.0	1.3	-0.1	1.4	-1.2	1.4
Multivitamins +/- minerals	1.0	1.3	3.5	-0.2	-1.9	-1.5	0.8	-0.1
Stomach or abdominal pain in last month	0.7	0.9	3.8	1.9	0.2	0.4	0.5	-0.2
Supplements: Glucosamine	0.2	0.3	0.8	0.9	0.1	0.1	-0.8	-0.1
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	10.8	3.3	0.3	-0.9	0.5	-0.8
Medication: Atenolol	1.2	1.5	3.8	-1.3	0.4	-1.1	1.9	-0.9
Medication: Levothyroxine sodium	4.5	7.6	16.7	0.4	-2.2	3.6	1.8	4.1
Sitting height	0.6	4.2	18.7	-4.3	1.4	-0.0	-0.0	-0.0
Chronic bronchitis/emphysema (father)	1.1	1.2	5.7	-0.7	-0.3	-0.1	2.4	-0.2
High blood pressure (mother)	0.8	1.1	2.3	-1.1	-1.5	-0.1	1.0	1.0
Body mass index (BMI)	0.3	1.3	3.2	0.8	1.8	1.4	0.9	-0.1
Impedance of leg (left)	0.2	0.8	1.4	1.0	-1.2	-0.2	-1.0	-0.7
Leg predicted mass (left)	0.5	2.7	6.0	-2.0	2.4	0.8	1.7	-0.2
Trunk fat mass	0.4	1.9	4.5	0.3	2.1	1.9	1.1	-0.1
Waist circumference	0.4	1.5	3.8	-0.8	1.9	1.6	0.7	0.1
Number of incorrect matches in round	0.2	0.4	1.0	0.6	1.0	0.3	-0.1	-0.7
Past tobacco smoking	1.3	2.4	6.3	0.7	0.6	-2.1	0.6	-2.5
Alcohol usually taken with meals	0.9	1.5	3.1	0.8	0.8	-1.8	-1.6	-0.7
Nervous feelings	0.7	1.3	2.5	0.4	-0.1	-1.6	-1.5	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	0.2	-1.1	-1.1	-0.1	0.1
Hearing difficulty/problems with background noise	0.6	1.0	3.8	-1.9	0.3	-0.0	-1.0	-0.3
Hair/balding pattern: Pattern 2	0.2	0.2	0.7	-0.2	0.6	0.1	0.8	-0.1
Had menopause	0.2	0.2	0.6	0.5	0.4	-0.8	0.3	0.1
Had other major operations	0.6	0.7	3.3	-1.8	-0.3	0.4	0.1	-0.0
Forced vital capacity (FVC)	0.2	0.6	1.3	0.7	1.1	-1.1	-0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.2	-1.1	0.7	0.1	-0.4	0.8
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	3.1	1.1	-1.5	1.2	-0.1	1.8
Qualifications: None of the above	0.4	0.9	3.2	-0.5	-0.8	0.5	1.8	0.6
Financial difficulties in last 2 years	0.3	0.5	0.8	0.3	-0.9	0.9	0.7	0.3
Mouth/teeth dental problems	0.1	0.2	0.3	-0.4	-0.5	-0.3	-0.5	0.5
Heart attack	0.2	0.2	0.5	0.6	-0.3	-0.1	-0.5	0.7
Allergy	0.6	1.4	3.2	-0.6	0.3	-1.3	1.8	-1.4
Pain all over the body in last month	0.1	0.1	0.3	0.1	0.3	0.5	-0.5	-0.3
Diabetes (self-reported)	0.2	0.3	0.8	-0.9	-0.4	0.6	0.1	0.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.5	0.7	-0.6	1.2	0.5	1.1
Medication: Ramipril	0.5	0.7	1.9	-1.4	0.7	0.4	-0.8	0.5
Medication: Simvastatin	1.1	1.5	3.3	-1.2	-1.4	-1.8	0.4	1.0
Fluid intelligence score	0.2	0.4	0.9	0.8	-0.3	-0.2	-1.0	0.5
Illnesses of siblings	0.7	1.0	3.0	0.1	-0.9	1.7	0.3	1.1
Neuroticism score	0.3	0.7	2.0	-0.4	-0.2	-1.4	-0.4	-1.0
Weight	0.4	2.1	7.6	-0.9	2.8	0.8	1.0	-0.7
Impedance of arm (right)	0.2	0.9	1.7	1.3	-0.9	1.1	-0.9	0.4
Arm fat percentage (right)	0.5	1.8	4.3	1.4	1.7	2.1	0.3	0.3
Trunk fat-free mass	0.6	3.6	9.2	-2.6	3.0	-0.7	0.4	-1.2
Hip circumference	0.3	1.2	3.4	-1.1	1.9	0.7	0.9	0.2
Time employed in main current job	0.8	1.0	2.3	1.0	1.1	1.5	0.3	-0.3
Alcohol intake versus 10 years previously	0.3	0.5	1.0	-0.5	-0.6	-1.0	0.7	-0.6
Father’s age at death	1.8	2.4	5.2	0.4	2.3	-0.7	-2.0	-1.5
Worrier / anxious feelings	0.1	0.2	0.6	-0.1	0.3	-0.2	-0.4	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.2	0.0	-0.3	-0.2	-1.5	0.4
Falls in the last year	0.2	0.2	0.5	-0.6	0.0	0.4	0.7	0.1
Hair/balding pattern: Pattern 3	0.6	0.9	1.9	0.8	0.8	1.4	-1.2	0.1
Number of live births	0.6	0.9	2.0	-1.1	-0.0	1.4	0.0	1.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.5	1.6	1.5	-1.1	0.4	-0.5
Pulse rate	1.2	2.1	3.5	-1.2	-1.6	1.9	0.8	1.5
Happiness	0.3	0.3	0.5	0.6	0.5	-0.5	-0.7	-0.4
Noisy workplace	1.4	1.7	4.5	0.3	0.5	-1.9	-0.4	-2.1
Qualifications: A levels/AS levels or equivalent	0.5	1.0	1.6	-0.5	1.1	-0.8	-1.3	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.3	-0.8	-0.0	1.2	0.1	0.7
Mouth/teeth dental problems: Dentures	1.4	2.3	5.4	0.8	-0.9	2.0	0.8	2.3
Asthma	0.3	0.6	2.6	-0.1	-0.7	-0.2	-1.6	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.9	-0.1	0.1	0.4	0.9	-0.3
Medication: Cholesterol lowering	0.5	0.7	2.0	-0.3	-0.8	-1.4	0.4	0.9
Depression (self-reported)	0.7	0.9	3.2	-0.1	0.4	-1.0	1.8	-0.2
Medication: Lansoprazole	1.1	1.2	3.1	1.2	0.5	1.8	0.5	1.0
Prospective memory result	0.1	0.1	0.2	0.5	0.4	-0.1	0.5	-0.1
Lung cancer (father)	0.7	0.8	1.4	-1.0	-1.0	0.6	-0.8	1.2
Illnesses of mother	0.2	0.3	0.6	0.7	0.2	0.7	0.4	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.8	1.2	1.4	-0.9	0.4	-0.6
Pulse wave Arterial Stiffness index	1.0	1.2	4.3	-0.2	0.5	-2.1	-1.1	-0.6
Impedance of arm (left)	0.3	1.5	2.4	1.0	-1.4	1.5	-0.7	1.2
Arm fat mass (right)	0.4	1.7	4.7	0.2	2.2	1.8	0.8	-0.1
Trunk predicted mass	0.6	3.6	9.0	-2.6	3.0	-0.7	0.4	-1.2
Standing height	0.4	4.3	13.1	-3.6	2.3	-1.0	0.5	-1.4
Length of working week for main job	0.6	0.7	3.0	0.2	0.2	0.5	1.7	0.2
Exposure to tobacco smoke at home	0.2	0.3	1.0	-1.0	-0.3	-0.1	-0.3	-0.4
Breastfed as a baby	1.4	1.8	3.0	1.7	1.2	-1.5	-0.2	-1.3
Tense / ‘highly strung’	0.7	1.1	4.4	-0.2	0.5	-0.9	-0.5	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.3	-0.3	0.5	0.7	-1.1	0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.1	0.5	0.6	-0.5	0.3
Birth weight of first child	1.6	2.9	4.0	-2.0	1.5	-1.6	-1.5	-1.8
Peak expiratory flow (PEF)	0.2	0.4	1.3	-0.3	1.1	-0.2	0.8	-0.1
Pulse wave reflection index	2.9	3.6	5.7	1.2	2.4	-1.9	-1.3	-2.3
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.0	-1.7	0.1	1.3	-0.7	0.4
Loud music exposure frequency	0.7	0.7	1.7	0.6	-0.3	1.1	-1.3	0.6
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	4.2	-0.1	1.1	-0.9	-1.0	-2.0
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	-0.2	-0.2	0.3	-0.3	-0.0
Blood clot in the leg (DVT)	1.4	1.8	3.1	-1.8	-1.1	1.1	0.8	1.6
Medication: Paracetamol	0.6	0.9	2.5	0.7	-0.3	1.2	1.6	0.3
Headache pain in last month	0.6	1.0	2.5	-1.3	0.6	-0.3	1.6	-0.7
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	2.4	1.5	1.2	0.5	-1.6	-0.9
Glaucoma (self-reported)	0.8	1.0	3.4	0.1	0.1	-1.1	-1.8	-0.4
Gout (self-reported)	0.2	0.3	0.9	-0.2	-0.5	0.5	0.3	1.0
Hypothyroidism/myxoedema (self-reported)	3.5	6.9	16.0	0.7	-2.6	2.8	1.8	4.0
Medication: Amlodipine	2.9	4.0	11.7	-0.8	-3.4	0.8	1.6	2.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.1	-0.8	0.9	-0.5	-1.4	-0.6
Birth weight	0.2	0.4	0.6	-0.4	0.8	-0.8	-0.6	-0.7
Chronic bronchitis/emphysema (mother)	2.0	2.4	6.2	0.1	2.5	-0.7	-1.5	-1.7
High blood pressure (siblings)	0.1	0.1	0.2	-0.4	0.3	0.4	-0.0	0.4
Forced vital capacity (FVC), Best measure	0.1	0.5	1.9	-0.1	1.4	-0.6	-0.1	-0.5
Body fat percentage	0.3	1.4	3.4	1.1	1.2	1.9	0.8	0.1
Leg fat percentage (right)	0.4	1.4	2.8	1.7	1.5	0.1	0.7	-1.2
Arm fat-free mass (right)	0.5	2.6	6.5	-2.0	2.5	-0.3	1.1	-1.0
Exposure to tobacco smoke outside home	0.9	1.3	3.1	-1.8	-0.2	-1.4	-0.6	-0.8
Comparative body size at age 10	1.3	3.6	7.0	2.7	2.2	-1.8	-1.3	-1.1
Number of full brothers	0.9	1.1	2.8	0.3	0.1	1.5	1.7	0.6
Worry too long after embarrassment	0.4	0.6	1.9	-1.4	-0.7	0.5	0.5	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.3	-0.3	-0.1	-0.8	-1.5	-0.9
Wheeze or whistling in the chest in last year	0.2	0.4	1.2	0.5	-0.1	-0.5	0.1	-1.1
Number of children fathered	1.2	1.4	3.3	1.6	0.8	1.8	-0.7	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.5	-0.2	-1.6	-1.2	-0.3	0.3
Age at first live birth	1.6	2.9	6.4	-1.2	0.7	-1.9	-2.5	-1.5
Pulse wave peak to peak time	1.1	1.3	4.6	-0.2	-0.5	2.2	1.1	0.5
Health satisfaction	0.7	0.9	1.5	1.2	-1.1	0.0	-0.9	1.1
Shortness of breath walking on level ground	0.3	0.3	0.8	0.3	0.8	0.1	-0.9	-0.1
Qualifications: College or University degree	0.3	0.9	2.8	0.2	-0.8	0.6	0.6	1.7
Eye problems/disorders: None of the above	0.3	0.3	0.6	-0.4	-0.8	-0.6	0.3	0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.7	0.6	0.8	-0.2	-1.3	-0.2
Emphysema/chronic bronchitis	1.7	1.9	3.4	1.1	1.3	-1.8	0.3	-1.8
Medication for pain relief, constipation, heartburn	0.9	1.5	4.0	-0.7	-0.1	-2.0	-0.6	-1.6
Neck or shoulder pain in last month	1.1	1.5	4.6	0.4	-1.2	2.1	0.8	0.8
Medication: Blood pressure	0.9	1.6	3.3	-1.8	-1.2	0.7	1.1	1.3
Angina (self-reported)	0.1	0.1	0.2	-0.4	-0.0	-0.4	-0.1	0.0
Migraine (self-reported)	0.1	0.1	0.4	-0.6	0.1	0.1	-0.3	0.2
Medication: Ibuprofen	0.2	0.2	0.5	-0.0	0.5	0.6	0.7	-0.3
Medication: Allopurinol	0.3	0.4	1.4	0.3	0.7	-0.4	-1.2	0.1
Medication: Omeprazole	3.4	4.0	11.2	1.2	-0.5	3.3	1.2	2.4
Medication: Seretide 50 evohaler	0.7	0.9	3.3	-0.4	-0.1	-0.0	-1.8	0.9
Mean time to correctly identify matches	0.9	1.8	3.7	-0.9	0.8	-1.9	-1.3	-1.4
Heart disease (mother)	0.5	0.6	1.6	-0.2	-1.0	0.2	0.6	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.5	1.6	0.2	-1.4	-0.8	-0.8
Whole body fat mass	0.4	1.7	4.6	0.1	2.2	1.7	0.9	-0.2
Leg fat mass (right)	0.3	1.3	4.7	0.4	2.2	0.5	0.8	-1.0
Arm predicted mass (right)	0.6	3.0	6.3	-2.4	2.5	-0.5	1.2	-1.0
Pulse rate, automated reading	1.3	4.1	11.3	-0.4	-1.5	3.4	1.1	2.3
Alcohol intake frequency.	0.8	1.8	5.4	-0.2	0.7	-1.7	-0.0	-2.3
Comparative height size at age 10	1.5	8.3	36.4	-6.0	0.3	-1.8	0.8	-1.1
Number of full sisters	0.4	0.5	1.5	-1.2	0.9	-0.1	0.5	-0.2
Suffer from ‘nerves’	0.5	0.8	2.1	0.9	-0.9	-1.4	0.1	0.0
Overall health rating	0.3	0.6	1.0	-0.6	-0.9	1.0	0.4	0.7
Chest pain or discomfort	0.2	0.3	0.9	-0.9	0.7	0.5	-0.1	-0.1
Had major operations	0.6	0.7	1.8	-0.4	-0.5	1.0	1.3	0.6
Age at last live birth	1.0	1.4	4.7	-1.0	0.3	-1.1	-2.2	0.3
Family relationship satisfaction	1.8	2.2	5.4	0.2	1.4	2.3	-1.1	1.5
Leg pain on walking	0.3	0.3	0.5	0.2	-0.7	-0.7	-0.7	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.7	0.9	-0.1	-0.5	0.1	-1.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.3	0.0	0.0	-0.1	-0.7	-1.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	0.5	0.8	-0.2	0.3	-0.5
Medication: Aspirin	0.7	1.0	3.5	0.3	-0.6	0.5	0.8	1.9
Supplements: Vitamin C	1.2	1.5	2.8	1.2	-1.7	-0.1	1.3	1.2
Knee pain experienced in last month	2.2	3.4	9.1	-1.4	-1.0	2.1	3.0	0.9
Hypertension (Self-reported)	0.6	1.6	4.4	-0.9	-2.1	-0.7	0.5	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.1	0.7	0.2	1.1	0.1	0.9
Illnesses of father: Heart disease	1.7	2.4	8.3	0.1	-0.9	0.5	2.9	1.6
Illnesses of siblings: Diabetes	0.3	0.4	1.0	-0.7	-0.5	-0.1	-1.0	-0.4
Smoking status: Previous	1.4	2.0	5.8	-1.0	-0.0	1.7	-0.6	2.4
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	5.0	-0.6	1.6	-0.4	0.8	-2.2
Whole body fat-free mass	0.5	3.1	7.9	-2.4	2.8	0.0	1.1	-0.8
Leg fat-free mass (right)	0.5	2.5	5.6	-2.0	2.4	0.9	1.4	0.1
Arm fat percentage (left)	0.6	2.2	5.8	1.6	1.5	2.4	0.5	0.6
Average weekly red wine intake	0.5	0.8	3.0	1.7	-0.1	-0.7	-0.5	0.6
Handedness (chirality/laterality): Left-handed	3.7	4.4	10.8	-1.2	1.4	-3.3	-0.2	-2.8
Mood swings	0.3	0.5	1.2	0.4	0.1	-1.1	-0.8	-0.8
Loneliness, isolation	0.2	0.3	1.3	1.1	0.6	0.1	0.0	0.0
Long-standing illness, disability or infirmity	1.4	2.1	5.8	-0.9	-0.7	2.4	1.1	1.6
Ever had bowel cancer screening	1.3	1.6	3.8	0.5	0.8	-1.8	-0.2	-1.9
Diabetes diagnosed by doctor	0.2	0.3	0.8	-0.8	-0.1	0.9	0.0	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	3.3	-1.8	0.4	0.3	-0.2	-0.2
Friendships satisfaction	1.1	1.3	3.0	-1.1	-0.6	1.7	0.3	1.4
Qualifications: nursing, teaching	0.4	0.6	1.3	-1.1	0.6	0.6	0.9	0.4
Commuting to job workplace: Walk	0.6	0.6	1.3	1.2	-0.1	0.8	0.4	1.0
Eye problems/disorders: Cataract	0.9	1.0	2.7	-0.6	-0.8	1.7	0.6	1.0
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	5.6	-0.1	1.4	-1.7	-1.7	-2.4
Medication for cholesterol	0.7	1.1	2.2	-0.1	1.2	1.5	-0.7	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.2	2.8	-1.5	-0.9	-0.7	-1.7	0.0
Back pain experienced in last month	1.2	1.8	6.4	-2.5	-1.1	-0.7	0.9	0.2
Mineral and other dietary supplements	0.6	0.9	2.8	-0.3	1.7	0.6	-0.4	-0.9
Breast cancer (self-reported)	1.0	1.2	2.7	-1.6	0.1	-1.6	0.8	-0.3
Asthma (self-reported)	0.2	0.5	1.7	-0.1	-0.8	-0.2	-1.3	-0.1
Osteoporosis (self-reported)	0.9	1.1	2.2	-1.5	-0.7	1.3	0.5	0.9
Osteoarthritis (self-reported)	0.6	0.7	1.7	1.3	0.9	-0.0	0.8	-0.6
Medication: Aspirin	0.5	0.6	1.8	0.1	-0.5	0.3	0.9	1.4
Medication: Gliclazide	0.5	0.6	1.3	-0.8	1.2	0.9	-0.0	-0.4
Illnesses of father: None of the above (group 1)	0.5	0.6	2.0	-0.2	-0.1	-0.5	-1.4	-0.8
Smoking status: Current	0.6	0.9	1.3	1.1	-1.0	1.2	1.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	6.2	2.1	0.6	-2.5	0.8	-0.8
Whole body water mass	0.5	3.1	8.5	-2.3	2.9	-0.1	1.0	-0.8
Leg predicted mass (right)	0.5	2.6	6.2	-2.0	2.5	0.8	1.5	0.0
Arm fat mass (left)	0.4	1.7	4.2	0.4	2.1	1.9	0.9	0.1
Number of self-reported non-cancer illnesses	1.7	2.9	6.0	-0.6	-2.5	1.0	1.1	2.4
Average weekly champagne plus white wine intake	0.9	1.2	3.0	-1.7	0.1	0.3	-1.7	0.3
Miserableness	0.1	0.2	0.4	0.0	-0.3	-0.7	-0.4	-0.6
Guilty feelings	0.2	0.3	1.1	-1.0	0.4	0.4	-0.0	-0.4
Wears glasses or contact lenses	2.2	2.5	8.9	0.8	1.4	-0.3	-3.0	1.0
Ever taken oral contraceptive pill	1.3	1.4	3.1	0.5	0.9	-1.8	0.5	-1.7
Hearing aid user	0.4	0.5	1.7	1.3	-0.5	-0.3	0.4	0.4
Mother’s age at death	0.8	1.1	4.0	2.0	0.4	-0.9	0.1	-0.6
Financial situation satisfaction	0.7	0.9	3.1	-0.8	0.1	0.7	-1.8	0.2
Tinnitus: Yes, now most or all of the time	0.7	0.9	2.1	-0.8	-0.9	-0.8	1.5	-0.1
Commuting to job workplace: Public transport	0.2	0.3	0.6	-0.6	0.3	-0.6	-0.1	0.8
Eye problems/disorders: Glaucoma	1.3	1.6	3.3	0.5	0.4	-1.8	-1.5	-1.5
Medication: Blood pressure	0.3	0.6	1.8	0.6	-0.9	0.2	0.3	1.3
Pain type(s) experienced in last month: Hip pain	0.8	1.0	4.0	-0.2	-0.8	0.2	2.0	-0.0
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	-0.4	-0.0	-0.3	-0.3	0.5
High cholesterol (Self-reported)	1.8	3.2	12.0	-0.5	-1.3	-3.5	0.9	1.1
Medication: Bendroflumethiazide	0.7	1.0	2.0	-1.4	-1.4	-0.6	0.9	0.1
Medication: Paracetamol	1.2	1.9	5.1	1.3	-0.6	1.4	2.3	0.9
Medication: Lisinopril	2.2	2.9	6.1	-1.5	-2.5	0.5	1.4	1.9
Medication: Atorvastatin	0.6	0.7	2.0	0.3	-0.1	-0.6	1.0	1.4
Illnesses of father: High blood pressure	1.0	1.2	2.3	0.8	-0.7	1.5	0.8	1.4
Alcohol drinker status: Never	0.4	0.5	1.0	0.9	-0.8	-0.1	-0.2	1.0
Ever smoked	1.5	2.6	6.7	-0.3	-1.2	2.0	-0.7	2.6
Basal metabolic rate	0.5	2.8	7.5	-2.1	2.7	0.3	1.2	-0.6
Leg fat percentage (left)	0.3	1.2	2.6	1.6	1.5	0.4	0.5	-0.8
Arm fat-free mass (left)	0.7	3.5	8.3	-2.5	2.9	-0.4	1.1	-1.2
Number of operations (self-reported)	0.6	0.8	2.9	-1.7	0.8	0.8	-0.1	0.2
Average weekly beer plus cider intake	1.1	1.6	4.9	-0.8	0.8	2.2	-0.8	1.0
Irritability	0.9	1.5	2.8	-0.3	-1.2	1.7	0.4	1.6
Risk taking	0.3	0.5	1.0	0.6	-0.4	1.0	0.3	0.9
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.2	-0.0	0.4	-1.1	0.3	-0.9
Fractured/broken bones in last 5 years	0.4	0.6	2.1	-0.5	-0.1	1.5	-0.4	0.5
Age started oral contraceptive pill	1.2	1.5	3.0	-0.3	1.3	-1.7	-0.5	-1.6
Diastolic blood pressure, automated reading	0.4	1.3	3.5	-0.6	-0.5	1.9	1.1	1.0
Ever depressed for a whole week	0.6	0.8	1.8	0.0	-0.4	1.3	-0.5	1.3
Unable to work because of sickness or disability	0.3	0.4	1.0	-1.0	-0.6	0.2	-0.6	0.4
Commuting to job workplace: Cycle	0.6	0.7	2.7	0.7	1.7	-0.3	-0.2	-0.3
Myopia	1.9	2.8	6.2	0.5	2.5	-1.0	-2.3	-1.2
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.0	1.4	1.7	0.5	-0.7	-1.2
Cholesterol lowering medication	1.1	1.7	4.4	-0.5	-0.9	-1.2	1.2	2.1
Medication: Omeprazole (e.g. Zanprol)	2.7	3.2	7.2	1.8	-0.6	2.7	0.6	2.3
Pain experienced in last month	0.4	0.6	1.5	1.2	0.2	-0.4	-1.1	0.5
Supplements: Calcium	0.1	0.2	0.6	-0.8	0.2	-0.3	0.1	0.2
Basal cell carcinoma (self-reported)	0.5	0.6	1.6	-0.5	1.2	-0.4	-0.5	-0.9
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.4	0.6	-0.2	-0.1	-0.4	0.5
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	3.2	-1.8	-0.9	1.1	0.9	1.5
Heart disease (siblings)	2.2	2.7	6.4	-0.4	1.2	-2.5	0.2	-2.3
Alcohol drinker status: Previous	1.0	1.1	3.3	-0.4	0.5	-1.2	-1.8	-0.8
Pack years of smoking	0.4	0.6	2.5	-1.6	0.0	-0.6	0.1	-0.1
Impedance of whole body	0.2	0.9	2.7	1.0	-1.6	0.7	-0.7	0.4
Leg fat mass (left)	0.3	1.3	4.8	0.2	2.2	0.8	0.8	-0.7
Arm predicted mass (left)	0.6	2.9	6.6	-2.2	2.6	-0.4	1.3	-1.1