Hub : Genes

HBP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1410	0.0440	3.5e-06	0.108	NA	0.061	NA	0.090	1.6e-05	NA	1.1e-03	NA	8.1e-05
2	NTR	Blood	0.0091	0.0049	8.7e-03	0.004	0.002	0.001	0.003	0.002	1.2e-02	4.6e-02	1.7e-01	4.2e-02	4.3e-02
3	ROSMAP	Brain Pre-frontal Cortex	0.0688	0.0220	2.7e-08	0.070	0.064	0.063	0.064	0.067	2.2e-09	1.3e-08	1.4e-08	1.3e-08	5.0e-09
4	YFS	Blood	0.0396	0.0118	3.0e-15	0.058	0.047	0.062	0.052	0.064	2.6e-18	3.0e-15	1.2e-19	1.2e-16	2.9e-20

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.0	1.5	1.9	-1.2	-1.4	0.9	1.3
Bipolar Disorder or Schizophrenia	0.7	1.7	4.3	-2.1	0.3	1.4	-0.7
Depressed Affect (Nagel 2018)	1.7	3.5	6.4	1.2	-2.5	-1.5	2.0
Depression (Nagel 2018)	1.3	1.9	3.2	-1.3	-1.4	0.9	1.8
Intelligence (Savage-Jansen 2018)	2.8	8.6	16.4	-4.0	1.5	4.0	0.3
Neuroticism (Nagel 2018)	0.2	0.4	0.6	0.5	-0.7	-0.8	0.4
Schizophrenia (2018)	1.2	2.6	4.0	-1.7	1.6	1.0	-2.0
Schizophrenia vs Biploar Disorder	1.2	1.6	3.1	-0.1	1.8	-0.3	-1.8
Worry (Nagel 2018)	0.0	0.1	0.1	-0.2	-0.2	-0.4	-0.1
Alzheimer’s Disease (in mother)	0.8	0.9	3.0	0.1	-0.9	0.2	1.7
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.2	0.2	-0.3	0.3
Alzheimer’s Disease (including proxy)	0.3	0.5	1.7	0.0	-0.3	-0.3	1.3
Crohns Disease (2017)	4.0	8.7	16.0	-4.0	2.0	3.4	-1.8
Irritable Bowel Disease (IBD)	2.4	5.7	11.5	-3.4	1.9	2.6	-1.1
Ulcerative Colitis (UC)	1.0	1.9	4.7	-2.2	1.1	1.4	-0.2
Major Depression (MDD)	2.9	3.5	7.8	0.3	-2.5	0.1	2.8
Reaction Time	0.2	0.3	1.1	0.2	0.4	0.0	-1.1
Verbal and Numeric Reasoning (VNR)	3.6	8.7	17.1	-4.1	1.8	3.8	0.0
Breast Cancer	2.2	5.2	12.2	1.0	2.5	-1.1	-3.5
Ovarian Cancer	0.4	0.5	1.4	0.2	1.2	0.2	-0.7
Prostate Cancer	0.3	0.4	0.6	-0.5	0.8	0.6	-0.4
Age at First Birth	1.4	2.0	4.8	1.8	0.1	-2.2	-0.4
Bipolar Disorder (2011)	0.5	0.5	0.8	-0.9	-0.7	0.3	0.8
Body Mass Index (BMI) (2010)	1.1	1.5	2.2	1.1	-1.5	-1.1	1.1
Coronary Artery Disease (CAD)	7.1	8.5	11.6	-2.2	3.1	2.8	-3.4
Crohns Disease (2012)	0.7	1.1	2.4	-1.5	0.3	1.2	-0.8
Mean Putamen Volume	0.4	0.4	0.7	0.8	0.5	-0.4	-0.8
Fasting Glucose	1.8	2.2	3.5	-1.5	-0.3	1.9	1.7
HbA1C	2.8	3.1	6.9	2.6	-0.4	-2.3	-0.2
HDL Cholesterol	2.9	4.9	10.4	3.2	-0.5	-3.0	0.0
LDL Cholesterol	4.5	7.2	8.7	-2.9	2.5	2.6	-2.6
Lupus	0.3	0.5	0.9	-0.5	1.0	0.6	-0.7
Neuroticism (2016)	1.6	2.4	4.5	1.2	-2.1	-1.2	1.5
Primary Biliary Cirrhosis	1.6	2.3	4.2	0.1	-2.0	-0.9	2.1
Rheumatoid Arthritis	1.2	1.7	3.0	1.0	1.6	-0.3	-1.7
Schizophrenia (2014)	0.9	2.1	3.9	-2.0	1.2	1.4	-1.0
Triglycerides	2.4	4.0	8.9	-0.2	-2.6	0.0	3.0
Type 2 Diabetes (T2D) (2012)	1.1	1.2	2.7	-0.4	-1.4	0.3	1.6
Ulcerative Colitis	1.3	1.9	3.2	-1.8	1.6	1.2	-0.4
Blood Eosinophil Count	0.0	0.1	0.3	0.5	0.1	-0.0	-0.3
Blood Platelet Count	0.2	2.7	5.3	1.4	-2.3	-1.7	-0.6
Blood Red Count	0.1	1.1	2.2	0.7	-0.1	-1.3	-1.5
Blood White Count	0.2	1.4	3.0	0.9	-1.7	-1.2	0.6
Heel T-Score	0.1	0.9	2.1	-0.7	-1.4	0.5	0.8
BMI	0.3	1.5	2.2	1.5	-1.2	-1.1	1.1
Height	0.5	9.4	17.7	-4.2	1.8	3.5	-2.0
Waist Hip Ratio (WHR)	1.2	5.3	11.8	0.2	-3.4	-0.4	3.0
Systolic Blood Pressure	1.4	7.0	10.5	-3.0	1.4	3.2	-2.5
Smoking Status	0.8	1.8	3.7	-0.9	1.4	1.9	-1.0
Allergy or Eczema	0.2	0.5	1.0	1.0	0.7	-0.3	-0.7
Cardiovascular Disease	3.9	12.9	18.1	-4.2	2.8	4.0	-3.0
Hypothyroidism (self reported)	0.2	0.6	1.6	-0.5	1.2	0.7	-0.0
Respiratory disease	0.8	1.8	2.2	1.5	-1.4	-1.0	1.4
Type 2 Diabetes (T2D) (2018)	0.8	1.4	2.8	-0.4	-1.5	0.6	1.7
Lung FEV1/FVC ratio	0.7	3.7	7.6	-2.5	0.5	2.8	0.7
Lung FVC	0.7	3.5	8.4	-0.8	2.9	0.6	-2.1
Neuroticism	0.2	0.5	0.7	0.8	-0.6	-0.8	0.4
Chronotype (morning person)	1.3	3.1	7.6	2.0	-0.7	-2.8	-0.2
Hair Pigment	0.0	0.1	0.3	0.0	0.6	-0.0	-0.3
Tanning	0.7	8.9	10.9	-2.6	3.3	3.0	-3.0
Hand grip strength (left)	1.6	4.3	6.6	-2.6	1.7	2.4	-1.4
Number of treatments/medications taken	1.6	2.9	4.3	-1.7	1.6	2.1	-1.3
Average weekly spirits intake	0.8	1.0	1.5	-1.2	1.0	1.2	-0.3
Sensitivity / hurt feelings	0.4	0.6	1.9	0.7	-0.0	-1.4	0.2
Frequency of depressed mood in last 2 weeks	0.9	1.3	1.9	-1.2	1.2	1.4	-0.6
Hearing difficulty/problems: Yes	1.1	1.7	2.7	-0.5	1.7	1.3	-1.4
Relative age of first facial hair	0.4	0.9	1.7	0.6	1.3	0.1	-1.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	-0.6	0.8	0.4	0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.3
Ever had hysterectomy (womb removed)	1.6	1.8	3.3	-1.8	-0.5	1.8	0.7
Systolic blood pressure, automated reading	0.4	1.2	3.5	-0.6	0.9	0.4	-1.9
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	3.6	-0.4	-1.6	0.6	1.9
Angina	4.2	5.5	9.8	-1.3	2.6	1.9	-3.1
Medication for hormone replacement therapy	0.1	0.1	0.2	0.1	0.4	-0.2	-0.3
Vitamin and mineral supplements	0.7	0.9	1.0	-0.9	1.0	1.0	-0.9
Supplements: Zinc	2.0	2.2	2.7	1.7	-1.6	-1.6	1.0
Medication: Co-codamol	0.2	0.2	0.6	-0.2	-0.4	-0.2	0.8
Medication: Metformin	0.5	0.7	1.3	0.7	-1.0	-0.5	1.1
Diabetes (father)	0.4	0.4	1.2	-0.6	-0.2	1.1	0.4
Diabetes (mother)	1.4	1.8	5.5	-0.5	-1.1	0.6	2.4
Severe depression (siblings)	0.2	0.3	0.8	0.4	-0.2	-0.9	-0.2
Pack years adult smoking proportion	1.1	1.7	2.7	-1.4	1.6	1.4	-0.5
Impedance of leg (right)	0.1	0.7	1.4	0.1	-1.0	-0.7	1.2
Leg fat-free mass (left)	0.2	1.0	2.3	-1.2	0.2	1.5	-0.2
Trunk fat percentage	0.5	2.0	2.8	1.4	-1.0	-1.4	1.7
Hand grip strength (right)	2.3	6.2	10.5	-3.2	1.8	3.1	-1.1
Townsend deprivation index at recruitment	2.3	3.2	6.5	-0.5	2.5	1.1	-2.2
Current tobacco smoking	0.2	0.3	0.6	-0.4	0.7	0.8	0.1
Average weekly fortified wine intake	0.3	0.3	0.6	-0.8	-0.5	0.4	0.6
Maternal smoking around birth	0.5	0.8	2.0	-0.7	0.7	1.4	-0.4
Fed-up feelings	0.1	0.2	0.4	0.3	-0.6	-0.6	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	2.3	-1.5	-0.7	1.3	1.3
Relative age voice broke	0.2	0.4	0.6	0.4	0.8	-0.4	-0.8
Taking other prescription medications	2.4	3.7	5.4	-2.2	2.0	2.3	-0.7
Age when periods started (menarche)	2.5	6.1	9.4	-2.1	2.7	1.8	-3.1
Bilateral oophorectomy (both ovaries removed)	3.8	4.4	4.9	-1.9	2.2	2.1	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.1	-1.2	-0.9	1.4	0.5
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.4	-0.5	0.5	0.1	-1.2
Qualifications: CSEs or equivalent	1.4	1.9	3.8	1.9	0.2	-1.4	-1.4
Serious illness, injury or assault to yourself	0.3	0.4	0.5	-0.7	0.6	0.6	-0.6
High blood pressure	1.0	2.7	5.3	-2.3	1.0	1.9	-1.0
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.7	0.5	1.2	0.2	-1.3
Multivitamins +/- minerals	0.3	0.4	0.8	0.0	-0.9	-0.1	0.8
Stomach or abdominal pain in last month	1.6	2.0	3.2	-1.1	1.8	1.7	-0.7
Supplements: Glucosamine	5.1	6.6	14.5	3.4	-0.7	-3.8	0.3
Diverticular disease/diverticulitis (self-reported)	2.4	2.9	6.9	-1.9	0.7	2.6	0.8
Medication: Atenolol	1.1	1.4	2.8	-1.7	0.9	0.7	-1.3
Medication: Levothyroxine sodium	0.2	0.3	0.9	-0.1	-0.1	0.5	0.9
Sitting height	0.0	0.1	0.2	-0.1	-0.5	-0.1	0.1
Chronic bronchitis/emphysema (father)	2.8	3.2	6.5	0.7	-2.3	-0.7	2.6
High blood pressure (mother)	0.5	0.8	1.1	-1.0	1.0	0.5	-0.8
Body mass index (BMI)	0.2	0.8	1.6	1.2	-0.4	-1.1	0.6
Impedance of leg (left)	0.2	0.9	1.5	0.4	-1.0	-1.0	1.2
Leg predicted mass (left)	0.2	1.0	2.3	-1.2	0.3	1.5	-0.2
Trunk fat mass	0.3	1.1	1.8	1.0	-0.8	-1.0	1.3
Waist circumference	0.3	1.1	1.4	0.9	-1.1	-1.2	1.0
Number of incorrect matches in round	0.4	0.6	2.1	-1.4	0.3	0.3	-0.3
Past tobacco smoking	2.7	4.9	8.5	2.2	-2.0	-2.9	1.5
Alcohol usually taken with meals	8.0	12.9	23.0	2.3	-4.8	-3.1	3.7
Nervous feelings	0.1	0.2	0.4	-0.6	-0.6	-0.2	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	-0.6	-0.2	0.1	0.7
Hearing difficulty/problems with background noise	1.8	2.9	6.2	-0.6	2.5	1.0	-2.0
Hair/balding pattern: Pattern 2	2.6	3.3	4.7	-2.2	1.5	2.0	-1.6
Had menopause	0.6	0.7	1.4	0.9	0.0	-0.9	1.2
Had other major operations	0.5	0.6	2.0	1.4	0.1	-0.3	-0.6
Forced vital capacity (FVC)	1.7	6.5	10.0	-2.1	3.2	1.8	-2.9
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	3.8	-1.8	0.0	1.9	-0.4
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	3.5	0.8	-1.3	-0.3	1.9
Qualifications: None of the above	1.0	2.1	4.7	-1.1	2.2	0.6	-1.4
Financial difficulties in last 2 years	1.5	2.0	5.3	-2.3	0.5	1.5	0.1
Mouth/teeth dental problems	0.4	0.7	1.1	-0.9	0.8	1.1	-0.1
Heart attack	1.9	2.4	3.4	-1.4	1.7	1.3	-1.8
Allergy	0.2	0.4	1.0	-1.0	0.1	0.7	0.0
Pain all over the body in last month	0.0	0.1	0.1	0.1	0.2	-0.4	0.0
Diabetes (self-reported)	0.2	0.2	0.7	-0.0	-0.5	0.3	0.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.7	1.3	0.2	-1.2	-0.2
Medication: Ramipril	1.5	1.9	5.8	-0.5	1.2	0.3	-2.4
Medication: Simvastatin	7.5	11.0	14.0	-2.8	3.6	2.9	-3.7
Fluid intelligence score	2.8	5.9	11.5	-3.4	1.4	3.2	-0.4
Illnesses of siblings	0.1	0.1	0.2	0.2	0.1	-0.2	0.5
Neuroticism score	0.3	0.6	1.2	1.0	-0.3	-1.1	-0.0
Weight	0.0	0.2	0.3	0.2	-0.5	-0.4	0.5
Impedance of arm (right)	0.1	0.5	1.7	0.2	-0.7	-0.1	1.3
Arm fat percentage (right)	0.4	1.5	2.9	1.7	-0.4	-1.4	1.0
Trunk fat-free mass	0.1	0.7	1.2	-1.1	0.3	1.0	-0.8
Hip circumference	0.1	0.5	1.2	0.9	-0.2	-1.1	0.3
Time employed in main current job	0.6	0.7	1.6	1.3	-0.3	-0.9	-0.3
Alcohol intake versus 10 years previously	0.2	0.3	0.9	-0.3	-0.5	-0.3	0.9
Father’s age at death	2.5	3.4	6.9	1.6	-1.1	-1.7	2.6
Worrier / anxious feelings	0.1	0.2	0.7	-0.0	-0.3	-0.9	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.7	0.2	-0.7	-0.4	1.3
Falls in the last year	1.0	1.4	1.8	-1.1	1.3	0.9	-1.3
Hair/balding pattern: Pattern 3	1.8	2.7	4.9	0.7	-2.2	-1.1	2.1
Number of live births	1.2	1.8	2.3	-0.9	1.5	1.5	-1.3
Forced expiratory volume in 1-second (FEV1)	2.0	6.8	9.2	-2.4	3.0	2.4	-2.6
Pulse rate	1.0	1.7	4.8	-0.3	-1.4	0.3	2.2
Happiness	0.3	0.4	0.9	-0.9	0.0	0.3	-0.6
Noisy workplace	0.1	0.1	0.3	0.4	-0.5	0.1	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.8	-0.3	-0.9	0.2	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.5	0.3	0.3	-0.0	-0.7
Mouth/teeth dental problems: Dentures	0.3	0.5	1.1	0.6	-0.7	-1.0	-0.1
Asthma	0.5	1.1	1.3	1.1	-1.1	-1.0	0.8
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.0	7.0	-0.5	-1.9	1.0	2.6
Medication: Cholesterol lowering	4.9	7.6	11.1	-2.2	2.8	2.5	-3.3
Depression (self-reported)	1.4	1.7	3.2	-1.8	0.9	1.4	-0.9
Medication: Lansoprazole	0.7	0.8	1.1	-1.1	0.7	1.0	-0.8
Prospective memory result	2.5	3.0	6.2	1.0	2.0	-1.0	-2.5
Lung cancer (father)	1.0	1.2	2.3	-0.5	1.3	1.5	-0.7
Illnesses of mother	0.3	0.4	1.0	0.6	0.5	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.9	7.7	-1.4	2.8	1.6	-2.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.8	0.9	0.2	-0.3	-0.1
Impedance of arm (left)	0.1	0.7	2.1	-0.1	-0.8	0.0	1.4
Arm fat mass (right)	0.2	0.9	1.4	1.2	-0.5	-1.0	0.9
Trunk predicted mass	0.1	0.7	1.1	-1.0	0.4	1.0	-0.9
Standing height	0.2	2.1	5.4	-2.3	-0.0	1.7	-0.2
Length of working week for main job	0.9	1.0	2.0	-0.1	-1.4	-0.1	1.4
Exposure to tobacco smoke at home	0.1	0.1	0.4	-0.4	0.6	0.1	0.0
Breastfed as a baby	0.6	0.7	1.6	0.8	0.4	-1.3	-0.6
Tense / ‘highly strung’	0.2	0.4	1.3	-1.1	0.4	0.3	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	3.7	5.7	10.6	-2.9	1.7	3.3	-0.6
Hair/balding pattern: Pattern 4	0.4	0.9	2.4	1.6	-0.2	-1.0	0.3
Birth weight of first child	0.8	1.4	2.3	-1.5	0.9	0.7	-1.4
Peak expiratory flow (PEF)	1.4	3.3	6.4	-2.0	1.6	2.5	-0.7
Pulse wave reflection index	1.0	1.2	1.6	1.2	1.2	-0.6	-1.2
Ever highly irritable/argumentative for 2 days	1.3	1.5	2.7	1.6	-1.5	-0.8	0.7
Loud music exposure frequency	0.1	0.1	0.2	-0.4	0.3	0.3	-0.4
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	2.5	-1.6	1.1	1.6	-0.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.7	0.9	-0.5	-0.1	0.6
Blood clot in the leg (DVT)	0.2	0.2	0.5	-0.4	0.3	0.7	-0.5
Medication: Paracetamol	0.1	0.2	0.7	0.0	-0.3	0.2	0.9
Headache pain in last month	0.4	0.7	1.8	0.4	-1.3	-0.6	0.7
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.2	0.9	-1.3	-1.1	2.0
Glaucoma (self-reported)	0.1	0.1	0.3	-0.1	-0.1	-0.3	0.6
Gout (self-reported)	1.2	1.6	3.7	-1.6	0.3	1.9	0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.5	-0.5	0.5	0.6	0.7
Medication: Amlodipine	0.7	0.9	2.1	-1.3	0.3	1.4	-0.2
Medication: Ventolin 100micrograms inhaler	2.1	2.7	4.3	1.1	-2.1	-1.3	2.0
Birth weight	8.5	18.5	26.6	-3.9	5.2	3.3	-4.6
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.2	-0.5	-0.3	0.4	0.4
High blood pressure (siblings)	0.1	0.1	0.2	0.4	-0.3	0.2	-0.4
Forced vital capacity (FVC), Best measure	1.0	3.7	6.8	-1.0	2.5	0.9	-2.6
Body fat percentage	0.4	1.8	2.3	1.5	-0.8	-1.5	1.4
Leg fat percentage (right)	0.6	2.1	3.6	1.7	-0.8	-1.9	1.2
Arm fat-free mass (right)	0.1	0.6	1.5	-1.2	0.0	0.9	-0.3
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.2	-0.3	0.4	0.5
Comparative body size at age 10	0.4	1.0	1.5	1.2	-0.9	-1.0	0.9
Number of full brothers	0.6	0.7	0.9	-0.8	1.0	0.9	0.7
Worry too long after embarrassment	2.0	3.4	7.8	2.8	-1.1	-2.1	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.2	5.9	-2.4	1.4	2.2	0.0
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.4	0.3	0.4	-0.1
Number of children fathered	1.4	1.5	3.2	0.2	-1.6	-0.4	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.6	0.2	0.6	-0.0	-0.8
Age at first live birth	0.6	1.1	1.8	1.3	-0.2	-1.3	-1.0
Pulse wave peak to peak time	0.2	0.2	0.6	-0.8	-0.4	0.2	0.2
Health satisfaction	3.4	4.4	7.2	-2.7	1.8	2.4	-1.2
Shortness of breath walking on level ground	0.5	0.6	0.9	-0.6	-1.0	0.5	0.8
Qualifications: College or University degree	0.3	1.1	1.9	0.7	-1.4	-0.8	1.1
Eye problems/disorders: None of the above	0.7	0.8	1.7	0.9	0.7	-0.5	-1.3
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.8	0.6	-0.6	-0.8	1.3
Emphysema/chronic bronchitis	0.8	1.0	1.3	0.9	-1.1	-1.1	0.8
Medication for pain relief, constipation, heartburn	0.6	1.0	1.7	1.3	-0.8	-1.3	0.5
Neck or shoulder pain in last month	0.2	0.3	0.5	-0.7	-0.3	0.3	0.7
Medication: Blood pressure	0.8	1.4	3.9	0.0	1.3	0.2	-2.0
Angina (self-reported)	4.4	5.7	10.2	-1.4	2.7	1.9	-3.2
Migraine (self-reported)	0.6	0.8	1.7	-1.3	0.2	1.1	-0.3
Medication: Ibuprofen	1.9	2.2	4.9	-0.7	-1.4	1.2	2.2
Medication: Allopurinol	0.5	0.6	1.5	0.0	-1.0	0.4	1.2
Medication: Omeprazole	0.7	0.9	1.1	-1.0	0.7	0.9	-1.0
Medication: Seretide 50 evohaler	2.3	2.7	4.1	1.2	-1.8	-1.4	2.0
Mean time to correctly identify matches	0.2	0.4	0.9	0.5	0.2	-0.5	-0.9
Heart disease (mother)	0.5	0.6	1.4	-1.2	0.6	0.0	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	6.0	7.1	10.9	-2.7	3.3	2.7	-1.7
Whole body fat mass	0.2	1.0	1.3	1.1	-0.7	-1.1	1.2
Leg fat mass (right)	0.2	0.7	1.1	0.8	-0.5	-0.9	1.0
Arm predicted mass (right)	0.1	0.5	1.3	-1.1	0.0	0.8	-0.4
Pulse rate, automated reading	0.5	1.7	3.1	-1.4	-0.4	1.2	1.8
Alcohol intake frequency.	1.4	3.3	4.8	1.3	-2.2	-1.9	1.6
Comparative height size at age 10	0.1	0.8	1.6	-0.2	-1.2	-0.1	1.3
Number of full sisters	0.2	0.2	0.6	-0.1	-0.2	0.8	0.5
Suffer from ‘nerves’	0.3	0.5	1.8	-0.3	-0.3	-0.0	1.4
Overall health rating	1.4	3.0	3.6	-1.4	1.9	1.8	-1.8
Chest pain or discomfort	0.5	0.7	1.0	-1.0	-0.9	0.3	1.0
Had major operations	1.5	1.7	5.2	2.3	-0.6	-1.1	-0.0
Age at last live birth	1.4	2.0	5.6	0.8	1.3	-0.5	-2.4
Family relationship satisfaction	0.5	0.6	1.2	-1.1	0.6	0.2	-0.8
Leg pain on walking	0.3	0.4	0.8	0.2	-0.9	0.5	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.0	0.1	0.1	1.0	0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.3	0.6	0.4	-0.6	-0.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.3	1.5	0.3	-1.0	0.1
Medication: Aspirin	2.5	3.3	5.0	-1.5	1.9	1.5	-2.2
Supplements: Vitamin C	0.9	1.0	2.4	1.6	-0.6	-1.0	0.6
Knee pain experienced in last month	0.7	1.1	1.7	1.3	0.1	-1.1	-1.3
Hypertension (Self-reported)	0.7	2.0	3.8	-2.0	0.8	1.5	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	2.7	-1.2	1.6	1.2	-1.4
Illnesses of father: Heart disease	1.8	2.5	6.7	-0.3	1.8	-0.1	-2.6
Illnesses of siblings: Diabetes	2.4	3.0	4.0	1.6	-1.7	-1.5	2.0
Smoking status: Previous	2.3	3.5	5.1	-1.9	1.7	2.3	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.5	-0.6	0.8	0.6	-1.6
Whole body fat-free mass	0.1	0.8	1.4	-1.2	0.2	1.2	-0.5
Leg fat-free mass (right)	0.2	1.0	2.3	-1.2	0.3	1.5	-0.4
Arm fat percentage (left)	0.3	1.3	2.0	1.4	-0.5	-1.2	1.1
Average weekly red wine intake	0.3	0.4	0.8	-0.6	0.5	0.3	-0.9
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.2	-0.4	0.0	-0.1
Mood swings	3.1	5.6	7.2	2.1	-2.7	-2.4	2.2
Loneliness, isolation	0.8	1.1	2.4	-1.6	0.9	1.0	-0.5
Long-standing illness, disability or infirmity	1.8	2.7	5.3	-2.2	0.7	2.3	-0.2
Ever had bowel cancer screening	2.6	3.0	4.1	2.0	-1.6	-1.8	1.5
Diabetes diagnosed by doctor	0.7	1.2	2.7	-0.5	-1.1	0.7	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	-0.5	0.2	0.9	0.5
Friendships satisfaction	1.4	1.7	3.5	-0.7	1.6	0.4	-1.9
Qualifications: nursing, teaching	0.6	1.0	2.0	1.4	-0.4	-1.4	-0.0
Commuting to job workplace: Walk	0.4	0.4	0.9	-1.0	0.1	0.8	0.1
Eye problems/disorders: Cataract	0.1	0.1	0.1	0.1	0.3	-0.4	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	-0.1	0.6	0.4	-0.4
Medication for cholesterol	4.0	6.1	9.9	3.1	-1.9	-3.0	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.4	-1.0	1.2	0.9	-0.2
Back pain experienced in last month	0.7	1.0	1.7	-0.8	1.3	0.4	-1.2
Mineral and other dietary supplements	5.7	7.7	15.5	-3.9	0.8	3.8	-0.1
Breast cancer (self-reported)	2.5	3.0	4.9	1.2	-2.2	-1.0	2.1
Asthma (self-reported)	0.6	1.1	1.4	1.2	-1.1	-1.0	0.8
Osteoporosis (self-reported)	0.9	1.1	2.4	-0.5	1.5	0.7	-1.2
Osteoarthritis (self-reported)	0.4	0.5	0.8	0.5	0.8	-0.6	-0.9
Medication: Aspirin	2.9	3.7	4.5	-1.8	1.9	1.9	-2.1
Medication: Gliclazide	1.3	1.5	2.9	1.3	-1.1	-0.4	1.7
Illnesses of father: None of the above (group 1)	0.5	0.6	2.0	-0.3	-0.7	0.1	1.4
Smoking status: Current	0.1	0.1	0.2	0.0	0.4	0.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	3.9	-1.4	1.5	2.0	-0.4
Whole body water mass	0.1	0.9	1.5	-1.2	0.4	1.2	-0.6
Leg predicted mass (right)	0.2	1.0	2.4	-1.2	0.3	1.6	-0.3
Arm fat mass (left)	0.2	0.7	1.0	1.0	-0.5	-0.9	0.7
Number of self-reported non-cancer illnesses	0.8	1.5	1.9	-1.2	1.4	0.9	-1.2
Average weekly champagne plus white wine intake	2.2	3.0	4.6	1.9	-1.9	-2.1	0.4
Miserableness	1.9	3.3	5.0	1.3	-2.2	-1.7	1.8
Guilty feelings	0.2	0.4	0.6	-0.3	0.8	0.5	-0.7
Wears glasses or contact lenses	0.2	0.3	0.6	-0.6	-0.2	0.4	0.8
Ever taken oral contraceptive pill	1.4	1.6	3.7	1.9	-1.3	-1.0	-0.0
Hearing aid user	0.3	0.4	0.9	0.1	0.7	0.3	-1.0
Mother’s age at death	0.7	0.8	2.0	0.8	-0.7	-1.4	0.4
Financial situation satisfaction	0.1	0.2	0.3	-0.4	0.5	0.2	-0.5
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.5	-1.6	0.1	1.1	0.5
Commuting to job workplace: Public transport	0.3	0.3	0.7	0.0	0.8	-0.1	-0.8
Eye problems/disorders: Glaucoma	0.5	0.5	1.3	-1.1	0.4	0.6	0.6
Medication: Blood pressure	1.2	2.3	6.1	-2.5	0.0	1.7	-0.1
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.0	0.1	-0.9	0.1	1.4
Supplements: Fish oil (including cod liver oil)	3.0	3.9	8.0	2.7	-0.7	-2.8	-0.3
High cholesterol (Self-reported)	6.0	10.6	12.3	-2.9	3.5	3.2	-3.4
Medication: Bendroflumethiazide	1.7	2.5	4.4	-1.4	1.5	1.1	-2.1
Medication: Paracetamol	0.3	0.5	1.1	-0.3	-0.1	0.8	1.1
Medication: Lisinopril	0.8	1.0	2.2	0.9	-0.9	-0.4	1.5
Medication: Atorvastatin	4.7	5.9	8.7	-2.5	1.8	2.9	-2.2
Illnesses of father: High blood pressure	1.0	1.3	2.4	-1.0	1.2	0.5	-1.6
Alcohol drinker status: Never	0.8	0.9	1.7	1.0	0.7	-1.3	-0.6
Ever smoked	2.0	3.6	5.4	-1.6	1.8	2.3	-1.8
Basal metabolic rate	0.1	0.4	0.7	-0.8	0.1	0.9	-0.3
Leg fat percentage (left)	0.6	2.0	3.8	1.7	-0.6	-1.9	1.0
Arm fat-free mass (left)	0.1	0.3	0.7	-0.8	0.2	0.6	-0.4
Number of operations (self-reported)	1.1	1.6	3.1	0.2	1.5	1.0	-1.8
Average weekly beer plus cider intake	0.7	1.0	1.7	1.3	0.8	-0.9	-0.8
Irritability	2.4	4.0	7.4	-1.3	2.7	1.5	-2.2
Risk taking	2.7	4.0	4.5	2.1	-2.1	-1.8	2.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.6	1.3	-0.6	-1.0	0.2
Fractured/broken bones in last 5 years	0.1	0.1	0.3	0.3	0.5	-0.5	0.2
Age started oral contraceptive pill	1.5	1.9	5.3	1.3	-0.6	-2.3	0.4
Diastolic blood pressure, automated reading	0.7	2.0	4.3	-1.0	2.1	1.1	-1.2
Ever depressed for a whole week	0.3	0.4	0.7	-0.8	-0.2	0.4	0.8
Unable to work because of sickness or disability	2.4	3.1	6.7	-2.6	0.7	2.3	0.1
Commuting to job workplace: Cycle	1.3	1.6	4.0	1.4	-0.4	-2.0	-0.0
Myopia	0.2	0.3	0.5	-0.2	-0.7	0.2	0.7
Vascular/heart problems diagnosed by doctor	1.4	3.9	6.3	2.5	-1.5	-2.0	1.7
Cholesterol lowering medication	4.9	7.2	9.6	-3.1	2.5	3.0	-2.1
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.5	-0.4	1.0	0.7	-1.6
Pain experienced in last month	0.1	0.1	0.3	0.5	0.1	-0.0	0.4
Supplements: Calcium	0.1	0.1	0.3	-0.1	0.5	0.1	0.6
Basal cell carcinoma (self-reported)	0.4	0.5	1.4	-0.4	0.4	1.2	-0.3
Heart attack/myocardial infarction (self-reported)	1.5	2.0	3.3	-1.0	1.6	1.0	-1.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	-0.3	0.3	0.6	-0.7
Heart disease (siblings)	5.2	6.4	10.2	-3.2	2.5	2.6	-1.4
Alcohol drinker status: Previous	2.4	2.8	4.9	-1.2	-2.1	0.8	2.2
Pack years of smoking	0.7	1.1	1.8	-1.0	1.4	1.2	-0.3
Impedance of whole body	0.1	0.7	1.8	0.1	-0.9	-0.4	1.3
Leg fat mass (left)	0.2	0.8	1.1	0.9	-0.5	-1.0	1.0
Arm predicted mass (left)	0.1	0.3	0.8	-0.9	-0.0	0.6	-0.4