Hub : Genes

HBP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.1410 0.0440 3.5e-06 0.108 NA 0.061 NA 0.090 1.6e-05 NA 1.1e-03 NA 8.1e-05
2 NTR Blood 0.0091 0.0049 8.7e-03 0.004 0.002 0.001 0.003 0.002 1.2e-02 4.6e-02 1.7e-01 4.2e-02 4.3e-02
3 ROSMAP Brain Pre-frontal Cortex 0.0688 0.0220 2.7e-08 0.070 0.064 0.063 0.064 0.067 2.2e-09 1.3e-08 1.4e-08 1.3e-08 5.0e-09
4 YFS Blood 0.0396 0.0118 3.0e-15 0.058 0.047 0.062 0.052 0.064 2.6e-18 3.0e-15 1.2e-19 1.2e-16 2.9e-20

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.0 1.5 1.9 -1.2 -1.4 0.9 1.3
Bipolar Disorder or Schizophrenia 0.7 1.7 4.3 -2.1 0.3 1.4 -0.7
Depressed Affect (Nagel 2018) 1.7 3.5 6.4 1.2 -2.5 -1.5 2.0
Depression (Nagel 2018) 1.3 1.9 3.2 -1.3 -1.4 0.9 1.8
Intelligence (Savage-Jansen 2018) 2.8 8.6 16.4 -4.0 1.5 4.0 0.3
Neuroticism (Nagel 2018) 0.2 0.4 0.6 0.5 -0.7 -0.8 0.4
Schizophrenia (2018) 1.2 2.6 4.0 -1.7 1.6 1.0 -2.0
Schizophrenia vs Biploar Disorder 1.2 1.6 3.1 -0.1 1.8 -0.3 -1.8
Worry (Nagel 2018) 0.0 0.1 0.1 -0.2 -0.2 -0.4 -0.1
Alzheimer’s Disease (in mother) 0.8 0.9 3.0 0.1 -0.9 0.2 1.7
Alzheimer’s Disease (in father) 0.1 0.1 0.1 0.2 0.2 -0.3 0.3
Alzheimer’s Disease (including proxy) 0.3 0.5 1.7 0.0 -0.3 -0.3 1.3
Crohns Disease (2017) 4.0 8.7 16.0 -4.0 2.0 3.4 -1.8
Irritable Bowel Disease (IBD) 2.4 5.7 11.5 -3.4 1.9 2.6 -1.1
Ulcerative Colitis (UC) 1.0 1.9 4.7 -2.2 1.1 1.4 -0.2
Major Depression (MDD) 2.9 3.5 7.8 0.3 -2.5 0.1 2.8
Reaction Time 0.2 0.3 1.1 0.2 0.4 0.0 -1.1
Verbal and Numeric Reasoning (VNR) 3.6 8.7 17.1 -4.1 1.8 3.8 0.0
Breast Cancer 2.2 5.2 12.2 1.0 2.5 -1.1 -3.5
Ovarian Cancer 0.4 0.5 1.4 0.2 1.2 0.2 -0.7
Prostate Cancer 0.3 0.4 0.6 -0.5 0.8 0.6 -0.4
Age at First Birth 1.4 2.0 4.8 1.8 0.1 -2.2 -0.4
Bipolar Disorder (2011) 0.5 0.5 0.8 -0.9 -0.7 0.3 0.8
Body Mass Index (BMI) (2010) 1.1 1.5 2.2 1.1 -1.5 -1.1 1.1
Coronary Artery Disease (CAD) 7.1 8.5 11.6 -2.2 3.1 2.8 -3.4
Crohns Disease (2012) 0.7 1.1 2.4 -1.5 0.3 1.2 -0.8
Mean Putamen Volume 0.4 0.4 0.7 0.8 0.5 -0.4 -0.8
Fasting Glucose 1.8 2.2 3.5 -1.5 -0.3 1.9 1.7
HbA1C 2.8 3.1 6.9 2.6 -0.4 -2.3 -0.2
HDL Cholesterol 2.9 4.9 10.4 3.2 -0.5 -3.0 0.0
LDL Cholesterol 4.5 7.2 8.7 -2.9 2.5 2.6 -2.6
Lupus 0.3 0.5 0.9 -0.5 1.0 0.6 -0.7
Neuroticism (2016) 1.6 2.4 4.5 1.2 -2.1 -1.2 1.5
Primary Biliary Cirrhosis 1.6 2.3 4.2 0.1 -2.0 -0.9 2.1
Rheumatoid Arthritis 1.2 1.7 3.0 1.0 1.6 -0.3 -1.7
Schizophrenia (2014) 0.9 2.1 3.9 -2.0 1.2 1.4 -1.0
Triglycerides 2.4 4.0 8.9 -0.2 -2.6 0.0 3.0
Type 2 Diabetes (T2D) (2012) 1.1 1.2 2.7 -0.4 -1.4 0.3 1.6
Ulcerative Colitis 1.3 1.9 3.2 -1.8 1.6 1.2 -0.4
Blood Eosinophil Count 0.0 0.1 0.3 0.5 0.1 -0.0 -0.3
Blood Platelet Count 0.2 2.7 5.3 1.4 -2.3 -1.7 -0.6
Blood Red Count 0.1 1.1 2.2 0.7 -0.1 -1.3 -1.5
Blood White Count 0.2 1.4 3.0 0.9 -1.7 -1.2 0.6
Heel T-Score 0.1 0.9 2.1 -0.7 -1.4 0.5 0.8
BMI 0.3 1.5 2.2 1.5 -1.2 -1.1 1.1
Height 0.5 9.4 17.7 -4.2 1.8 3.5 -2.0
Waist Hip Ratio (WHR) 1.2 5.3 11.8 0.2 -3.4 -0.4 3.0
Systolic Blood Pressure 1.4 7.0 10.5 -3.0 1.4 3.2 -2.5
Smoking Status 0.8 1.8 3.7 -0.9 1.4 1.9 -1.0
Allergy or Eczema 0.2 0.5 1.0 1.0 0.7 -0.3 -0.7
Cardiovascular Disease 3.9 12.9 18.1 -4.2 2.8 4.0 -3.0
Hypothyroidism (self reported) 0.2 0.6 1.6 -0.5 1.2 0.7 -0.0
Respiratory disease 0.8 1.8 2.2 1.5 -1.4 -1.0 1.4
Type 2 Diabetes (T2D) (2018) 0.8 1.4 2.8 -0.4 -1.5 0.6 1.7
Lung FEV1/FVC ratio 0.7 3.7 7.6 -2.5 0.5 2.8 0.7
Lung FVC 0.7 3.5 8.4 -0.8 2.9 0.6 -2.1
Neuroticism 0.2 0.5 0.7 0.8 -0.6 -0.8 0.4
Chronotype (morning person) 1.3 3.1 7.6 2.0 -0.7 -2.8 -0.2
Hair Pigment 0.0 0.1 0.3 0.0 0.6 -0.0 -0.3
Tanning 0.7 8.9 10.9 -2.6 3.3 3.0 -3.0
Hand grip strength (left) 1.6 4.3 6.6 -2.6 1.7 2.4 -1.4
Number of treatments/medications taken 1.6 2.9 4.3 -1.7 1.6 2.1 -1.3
Average weekly spirits intake 0.8 1.0 1.5 -1.2 1.0 1.2 -0.3
Sensitivity / hurt feelings 0.4 0.6 1.9 0.7 -0.0 -1.4 0.2
Frequency of depressed mood in last 2 weeks 0.9 1.3 1.9 -1.2 1.2 1.4 -0.6
Hearing difficulty/problems: Yes 1.1 1.7 2.7 -0.5 1.7 1.3 -1.4
Relative age of first facial hair 0.4 0.9 1.7 0.6 1.3 0.1 -1.2
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.6 -0.6 0.8 0.4 0.3
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.1 -0.2 -0.3 -0.3 0.3
Ever had hysterectomy (womb removed) 1.6 1.8 3.3 -1.8 -0.5 1.8 0.7
Systolic blood pressure, automated reading 0.4 1.2 3.5 -0.6 0.9 0.4 -1.9
Eye problems/disorders: Diabetes related eye disease 1.5 1.6 3.6 -0.4 -1.6 0.6 1.9
Angina 4.2 5.5 9.8 -1.3 2.6 1.9 -3.1
Medication for hormone replacement therapy 0.1 0.1 0.2 0.1 0.4 -0.2 -0.3
Vitamin and mineral supplements 0.7 0.9 1.0 -0.9 1.0 1.0 -0.9
Supplements: Zinc 2.0 2.2 2.7 1.7 -1.6 -1.6 1.0
Medication: Co-codamol 0.2 0.2 0.6 -0.2 -0.4 -0.2 0.8
Medication: Metformin 0.5 0.7 1.3 0.7 -1.0 -0.5 1.1
Diabetes (father) 0.4 0.4 1.2 -0.6 -0.2 1.1 0.4
Diabetes (mother) 1.4 1.8 5.5 -0.5 -1.1 0.6 2.4
Severe depression (siblings) 0.2 0.3 0.8 0.4 -0.2 -0.9 -0.2
Pack years adult smoking proportion 1.1 1.7 2.7 -1.4 1.6 1.4 -0.5
Impedance of leg (right) 0.1 0.7 1.4 0.1 -1.0 -0.7 1.2
Leg fat-free mass (left) 0.2 1.0 2.3 -1.2 0.2 1.5 -0.2
Trunk fat percentage 0.5 2.0 2.8 1.4 -1.0 -1.4 1.7
Hand grip strength (right) 2.3 6.2 10.5 -3.2 1.8 3.1 -1.1
Townsend deprivation index at recruitment 2.3 3.2 6.5 -0.5 2.5 1.1 -2.2
Current tobacco smoking 0.2 0.3 0.6 -0.4 0.7 0.8 0.1
Average weekly fortified wine intake 0.3 0.3 0.6 -0.8 -0.5 0.4 0.6
Maternal smoking around birth 0.5 0.8 2.0 -0.7 0.7 1.4 -0.4
Fed-up feelings 0.1 0.2 0.4 0.3 -0.6 -0.6 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 2.3 -1.5 -0.7 1.3 1.3
Relative age voice broke 0.2 0.4 0.6 0.4 0.8 -0.4 -0.8
Taking other prescription medications 2.4 3.7 5.4 -2.2 2.0 2.3 -0.7
Age when periods started (menarche) 2.5 6.1 9.4 -2.1 2.7 1.8 -3.1
Bilateral oophorectomy (both ovaries removed) 3.8 4.4 4.9 -1.9 2.2 2.1 -2.2
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 2.1 -1.2 -0.9 1.4 0.5
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.4 -0.5 0.5 0.1 -1.2
Qualifications: CSEs or equivalent 1.4 1.9 3.8 1.9 0.2 -1.4 -1.4
Serious illness, injury or assault to yourself 0.3 0.4 0.5 -0.7 0.6 0.6 -0.6
High blood pressure 1.0 2.7 5.3 -2.3 1.0 1.9 -1.0
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.7 0.5 1.2 0.2 -1.3
Multivitamins +/- minerals 0.3 0.4 0.8 0.0 -0.9 -0.1 0.8
Stomach or abdominal pain in last month 1.6 2.0 3.2 -1.1 1.8 1.7 -0.7
Supplements: Glucosamine 5.1 6.6 14.5 3.4 -0.7 -3.8 0.3
Diverticular disease/diverticulitis (self-reported) 2.4 2.9 6.9 -1.9 0.7 2.6 0.8
Medication: Atenolol 1.1 1.4 2.8 -1.7 0.9 0.7 -1.3
Medication: Levothyroxine sodium 0.2 0.3 0.9 -0.1 -0.1 0.5 0.9
Sitting height 0.0 0.1 0.2 -0.1 -0.5 -0.1 0.1
Chronic bronchitis/emphysema (father) 2.8 3.2 6.5 0.7 -2.3 -0.7 2.6
High blood pressure (mother) 0.5 0.8 1.1 -1.0 1.0 0.5 -0.8
Body mass index (BMI) 0.2 0.8 1.6 1.2 -0.4 -1.1 0.6
Impedance of leg (left) 0.2 0.9 1.5 0.4 -1.0 -1.0 1.2
Leg predicted mass (left) 0.2 1.0 2.3 -1.2 0.3 1.5 -0.2
Trunk fat mass 0.3 1.1 1.8 1.0 -0.8 -1.0 1.3
Waist circumference 0.3 1.1 1.4 0.9 -1.1 -1.2 1.0
Number of incorrect matches in round 0.4 0.6 2.1 -1.4 0.3 0.3 -0.3
Past tobacco smoking 2.7 4.9 8.5 2.2 -2.0 -2.9 1.5
Alcohol usually taken with meals 8.0 12.9 23.0 2.3 -4.8 -3.1 3.7
Nervous feelings 0.1 0.2 0.4 -0.6 -0.6 -0.2 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.5 -0.6 -0.2 0.1 0.7
Hearing difficulty/problems with background noise 1.8 2.9 6.2 -0.6 2.5 1.0 -2.0
Hair/balding pattern: Pattern 2 2.6 3.3 4.7 -2.2 1.5 2.0 -1.6
Had menopause 0.6 0.7 1.4 0.9 0.0 -0.9 1.2
Had other major operations 0.5 0.6 2.0 1.4 0.1 -0.3 -0.6
Forced vital capacity (FVC) 1.7 6.5 10.0 -2.1 3.2 1.8 -2.9
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 3.8 -1.8 0.0 1.9 -0.4
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 3.5 0.8 -1.3 -0.3 1.9
Qualifications: None of the above 1.0 2.1 4.7 -1.1 2.2 0.6 -1.4
Financial difficulties in last 2 years 1.5 2.0 5.3 -2.3 0.5 1.5 0.1
Mouth/teeth dental problems 0.4 0.7 1.1 -0.9 0.8 1.1 -0.1
Heart attack 1.9 2.4 3.4 -1.4 1.7 1.3 -1.8
Allergy 0.2 0.4 1.0 -1.0 0.1 0.7 0.0
Pain all over the body in last month 0.0 0.1 0.1 0.1 0.2 -0.4 0.0
Diabetes (self-reported) 0.2 0.2 0.7 -0.0 -0.5 0.3 0.8
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.7 1.3 0.2 -1.2 -0.2
Medication: Ramipril 1.5 1.9 5.8 -0.5 1.2 0.3 -2.4
Medication: Simvastatin 7.5 11.0 14.0 -2.8 3.6 2.9 -3.7
Fluid intelligence score 2.8 5.9 11.5 -3.4 1.4 3.2 -0.4
Illnesses of siblings 0.1 0.1 0.2 0.2 0.1 -0.2 0.5
Neuroticism score 0.3 0.6 1.2 1.0 -0.3 -1.1 -0.0
Weight 0.0 0.2 0.3 0.2 -0.5 -0.4 0.5
Impedance of arm (right) 0.1 0.5 1.7 0.2 -0.7 -0.1 1.3
Arm fat percentage (right) 0.4 1.5 2.9 1.7 -0.4 -1.4 1.0
Trunk fat-free mass 0.1 0.7 1.2 -1.1 0.3 1.0 -0.8
Hip circumference 0.1 0.5 1.2 0.9 -0.2 -1.1 0.3
Time employed in main current job 0.6 0.7 1.6 1.3 -0.3 -0.9 -0.3
Alcohol intake versus 10 years previously 0.2 0.3 0.9 -0.3 -0.5 -0.3 0.9
Father’s age at death 2.5 3.4 6.9 1.6 -1.1 -1.7 2.6
Worrier / anxious feelings 0.1 0.2 0.7 -0.0 -0.3 -0.9 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.7 0.2 -0.7 -0.4 1.3
Falls in the last year 1.0 1.4 1.8 -1.1 1.3 0.9 -1.3
Hair/balding pattern: Pattern 3 1.8 2.7 4.9 0.7 -2.2 -1.1 2.1
Number of live births 1.2 1.8 2.3 -0.9 1.5 1.5 -1.3
Forced expiratory volume in 1-second (FEV1) 2.0 6.8 9.2 -2.4 3.0 2.4 -2.6
Pulse rate 1.0 1.7 4.8 -0.3 -1.4 0.3 2.2
Happiness 0.3 0.4 0.9 -0.9 0.0 0.3 -0.6
Noisy workplace 0.1 0.1 0.3 0.4 -0.5 0.1 0.3
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.8 -0.3 -0.9 0.2 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.5 0.3 0.3 -0.0 -0.7
Mouth/teeth dental problems: Dentures 0.3 0.5 1.1 0.6 -0.7 -1.0 -0.1
Asthma 0.5 1.1 1.3 1.1 -1.1 -1.0 0.8
Medication: Ibuprofen (e.g. Nurofen) 2.4 3.0 7.0 -0.5 -1.9 1.0 2.6
Medication: Cholesterol lowering 4.9 7.6 11.1 -2.2 2.8 2.5 -3.3
Depression (self-reported) 1.4 1.7 3.2 -1.8 0.9 1.4 -0.9
Medication: Lansoprazole 0.7 0.8 1.1 -1.1 0.7 1.0 -0.8
Prospective memory result 2.5 3.0 6.2 1.0 2.0 -1.0 -2.5
Lung cancer (father) 1.0 1.2 2.3 -0.5 1.3 1.5 -0.7
Illnesses of mother 0.3 0.4 1.0 0.6 0.5 -0.2 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.5 4.9 7.7 -1.4 2.8 1.6 -2.7
Pulse wave Arterial Stiffness index 0.2 0.2 0.8 0.9 0.2 -0.3 -0.1
Impedance of arm (left) 0.1 0.7 2.1 -0.1 -0.8 0.0 1.4
Arm fat mass (right) 0.2 0.9 1.4 1.2 -0.5 -1.0 0.9
Trunk predicted mass 0.1 0.7 1.1 -1.0 0.4 1.0 -0.9
Standing height 0.2 2.1 5.4 -2.3 -0.0 1.7 -0.2
Length of working week for main job 0.9 1.0 2.0 -0.1 -1.4 -0.1 1.4
Exposure to tobacco smoke at home 0.1 0.1 0.4 -0.4 0.6 0.1 0.0
Breastfed as a baby 0.6 0.7 1.6 0.8 0.4 -1.3 -0.6
Tense / ‘highly strung’ 0.2 0.4 1.3 -1.1 0.4 0.3 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 3.7 5.7 10.6 -2.9 1.7 3.3 -0.6
Hair/balding pattern: Pattern 4 0.4 0.9 2.4 1.6 -0.2 -1.0 0.3
Birth weight of first child 0.8 1.4 2.3 -1.5 0.9 0.7 -1.4
Peak expiratory flow (PEF) 1.4 3.3 6.4 -2.0 1.6 2.5 -0.7
Pulse wave reflection index 1.0 1.2 1.6 1.2 1.2 -0.6 -1.2
Ever highly irritable/argumentative for 2 days 1.3 1.5 2.7 1.6 -1.5 -0.8 0.7
Loud music exposure frequency 0.1 0.1 0.2 -0.4 0.3 0.3 -0.4
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 2.5 -1.6 1.1 1.6 -0.8
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.7 0.9 -0.5 -0.1 0.6
Blood clot in the leg (DVT) 0.2 0.2 0.5 -0.4 0.3 0.7 -0.5
Medication: Paracetamol 0.1 0.2 0.7 0.0 -0.3 0.2 0.9
Headache pain in last month 0.4 0.7 1.8 0.4 -1.3 -0.6 0.7
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 4.2 0.9 -1.3 -1.1 2.0
Glaucoma (self-reported) 0.1 0.1 0.3 -0.1 -0.1 -0.3 0.6
Gout (self-reported) 1.2 1.6 3.7 -1.6 0.3 1.9 0.2
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.5 -0.5 0.5 0.6 0.7
Medication: Amlodipine 0.7 0.9 2.1 -1.3 0.3 1.4 -0.2
Medication: Ventolin 100micrograms inhaler 2.1 2.7 4.3 1.1 -2.1 -1.3 2.0
Birth weight 8.5 18.5 26.6 -3.9 5.2 3.3 -4.6
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.2 -0.5 -0.3 0.4 0.4
High blood pressure (siblings) 0.1 0.1 0.2 0.4 -0.3 0.2 -0.4
Forced vital capacity (FVC), Best measure 1.0 3.7 6.8 -1.0 2.5 0.9 -2.6
Body fat percentage 0.4 1.8 2.3 1.5 -0.8 -1.5 1.4
Leg fat percentage (right) 0.6 2.1 3.6 1.7 -0.8 -1.9 1.2
Arm fat-free mass (right) 0.1 0.6 1.5 -1.2 0.0 0.9 -0.3
Exposure to tobacco smoke outside home 0.1 0.1 0.3 0.2 -0.3 0.4 0.5
Comparative body size at age 10 0.4 1.0 1.5 1.2 -0.9 -1.0 0.9
Number of full brothers 0.6 0.7 0.9 -0.8 1.0 0.9 0.7
Worry too long after embarrassment 2.0 3.4 7.8 2.8 -1.1 -2.1 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 2.5 3.2 5.9 -2.4 1.4 2.2 0.0
Wheeze or whistling in the chest in last year 0.1 0.1 0.2 -0.4 0.3 0.4 -0.1
Number of children fathered 1.4 1.5 3.2 0.2 -1.6 -0.4 1.8
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.6 0.2 0.6 -0.0 -0.8
Age at first live birth 0.6 1.1 1.8 1.3 -0.2 -1.3 -1.0
Pulse wave peak to peak time 0.2 0.2 0.6 -0.8 -0.4 0.2 0.2
Health satisfaction 3.4 4.4 7.2 -2.7 1.8 2.4 -1.2
Shortness of breath walking on level ground 0.5 0.6 0.9 -0.6 -1.0 0.5 0.8
Qualifications: College or University degree 0.3 1.1 1.9 0.7 -1.4 -0.8 1.1
Eye problems/disorders: None of the above 0.7 0.8 1.7 0.9 0.7 -0.5 -1.3
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.8 0.6 -0.6 -0.8 1.3
Emphysema/chronic bronchitis 0.8 1.0 1.3 0.9 -1.1 -1.1 0.8
Medication for pain relief, constipation, heartburn 0.6 1.0 1.7 1.3 -0.8 -1.3 0.5
Neck or shoulder pain in last month 0.2 0.3 0.5 -0.7 -0.3 0.3 0.7
Medication: Blood pressure 0.8 1.4 3.9 0.0 1.3 0.2 -2.0
Angina (self-reported) 4.4 5.7 10.2 -1.4 2.7 1.9 -3.2
Migraine (self-reported) 0.6 0.8 1.7 -1.3 0.2 1.1 -0.3
Medication: Ibuprofen 1.9 2.2 4.9 -0.7 -1.4 1.2 2.2
Medication: Allopurinol 0.5 0.6 1.5 0.0 -1.0 0.4 1.2
Medication: Omeprazole 0.7 0.9 1.1 -1.0 0.7 0.9 -1.0
Medication: Seretide 50 evohaler 2.3 2.7 4.1 1.2 -1.8 -1.4 2.0
Mean time to correctly identify matches 0.2 0.4 0.9 0.5 0.2 -0.5 -0.9
Heart disease (mother) 0.5 0.6 1.4 -1.2 0.6 0.0 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 6.0 7.1 10.9 -2.7 3.3 2.7 -1.7
Whole body fat mass 0.2 1.0 1.3 1.1 -0.7 -1.1 1.2
Leg fat mass (right) 0.2 0.7 1.1 0.8 -0.5 -0.9 1.0
Arm predicted mass (right) 0.1 0.5 1.3 -1.1 0.0 0.8 -0.4
Pulse rate, automated reading 0.5 1.7 3.1 -1.4 -0.4 1.2 1.8
Alcohol intake frequency. 1.4 3.3 4.8 1.3 -2.2 -1.9 1.6
Comparative height size at age 10 0.1 0.8 1.6 -0.2 -1.2 -0.1 1.3
Number of full sisters 0.2 0.2 0.6 -0.1 -0.2 0.8 0.5
Suffer from ‘nerves’ 0.3 0.5 1.8 -0.3 -0.3 -0.0 1.4
Overall health rating 1.4 3.0 3.6 -1.4 1.9 1.8 -1.8
Chest pain or discomfort 0.5 0.7 1.0 -1.0 -0.9 0.3 1.0
Had major operations 1.5 1.7 5.2 2.3 -0.6 -1.1 -0.0
Age at last live birth 1.4 2.0 5.6 0.8 1.3 -0.5 -2.4
Family relationship satisfaction 0.5 0.6 1.2 -1.1 0.6 0.2 -0.8
Leg pain on walking 0.3 0.4 0.8 0.2 -0.9 0.5 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 1.0 0.1 0.1 1.0 0.1
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.3 0.6 0.4 -0.6 -0.5
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 2.3 1.5 0.3 -1.0 0.1
Medication: Aspirin 2.5 3.3 5.0 -1.5 1.9 1.5 -2.2
Supplements: Vitamin C 0.9 1.0 2.4 1.6 -0.6 -1.0 0.6
Knee pain experienced in last month 0.7 1.1 1.7 1.3 0.1 -1.1 -1.3
Hypertension (Self-reported) 0.7 2.0 3.8 -2.0 0.8 1.5 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.9 2.7 -1.2 1.6 1.2 -1.4
Illnesses of father: Heart disease 1.8 2.5 6.7 -0.3 1.8 -0.1 -2.6
Illnesses of siblings: Diabetes 2.4 3.0 4.0 1.6 -1.7 -1.5 2.0
Smoking status: Previous 2.3 3.5 5.1 -1.9 1.7 2.3 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 2.5 -0.6 0.8 0.6 -1.6
Whole body fat-free mass 0.1 0.8 1.4 -1.2 0.2 1.2 -0.5
Leg fat-free mass (right) 0.2 1.0 2.3 -1.2 0.3 1.5 -0.4
Arm fat percentage (left) 0.3 1.3 2.0 1.4 -0.5 -1.2 1.1
Average weekly red wine intake 0.3 0.4 0.8 -0.6 0.5 0.3 -0.9
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.1 0.2 -0.4 0.0 -0.1
Mood swings 3.1 5.6 7.2 2.1 -2.7 -2.4 2.2
Loneliness, isolation 0.8 1.1 2.4 -1.6 0.9 1.0 -0.5
Long-standing illness, disability or infirmity 1.8 2.7 5.3 -2.2 0.7 2.3 -0.2
Ever had bowel cancer screening 2.6 3.0 4.1 2.0 -1.6 -1.8 1.5
Diabetes diagnosed by doctor 0.7 1.2 2.7 -0.5 -1.1 0.7 1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.8 -0.5 0.2 0.9 0.5
Friendships satisfaction 1.4 1.7 3.5 -0.7 1.6 0.4 -1.9
Qualifications: nursing, teaching 0.6 1.0 2.0 1.4 -0.4 -1.4 -0.0
Commuting to job workplace: Walk 0.4 0.4 0.9 -1.0 0.1 0.8 0.1
Eye problems/disorders: Cataract 0.1 0.1 0.1 0.1 0.3 -0.4 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.3 -0.1 0.6 0.4 -0.4
Medication for cholesterol 4.0 6.1 9.9 3.1 -1.9 -3.0 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.4 -1.0 1.2 0.9 -0.2
Back pain experienced in last month 0.7 1.0 1.7 -0.8 1.3 0.4 -1.2
Mineral and other dietary supplements 5.7 7.7 15.5 -3.9 0.8 3.8 -0.1
Breast cancer (self-reported) 2.5 3.0 4.9 1.2 -2.2 -1.0 2.1
Asthma (self-reported) 0.6 1.1 1.4 1.2 -1.1 -1.0 0.8
Osteoporosis (self-reported) 0.9 1.1 2.4 -0.5 1.5 0.7 -1.2
Osteoarthritis (self-reported) 0.4 0.5 0.8 0.5 0.8 -0.6 -0.9
Medication: Aspirin 2.9 3.7 4.5 -1.8 1.9 1.9 -2.1
Medication: Gliclazide 1.3 1.5 2.9 1.3 -1.1 -0.4 1.7
Illnesses of father: None of the above (group 1) 0.5 0.6 2.0 -0.3 -0.7 0.1 1.4
Smoking status: Current 0.1 0.1 0.2 0.0 0.4 0.4 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 3.9 -1.4 1.5 2.0 -0.4
Whole body water mass 0.1 0.9 1.5 -1.2 0.4 1.2 -0.6
Leg predicted mass (right) 0.2 1.0 2.4 -1.2 0.3 1.6 -0.3
Arm fat mass (left) 0.2 0.7 1.0 1.0 -0.5 -0.9 0.7
Number of self-reported non-cancer illnesses 0.8 1.5 1.9 -1.2 1.4 0.9 -1.2
Average weekly champagne plus white wine intake 2.2 3.0 4.6 1.9 -1.9 -2.1 0.4
Miserableness 1.9 3.3 5.0 1.3 -2.2 -1.7 1.8
Guilty feelings 0.2 0.4 0.6 -0.3 0.8 0.5 -0.7
Wears glasses or contact lenses 0.2 0.3 0.6 -0.6 -0.2 0.4 0.8
Ever taken oral contraceptive pill 1.4 1.6 3.7 1.9 -1.3 -1.0 -0.0
Hearing aid user 0.3 0.4 0.9 0.1 0.7 0.3 -1.0
Mother’s age at death 0.7 0.8 2.0 0.8 -0.7 -1.4 0.4
Financial situation satisfaction 0.1 0.2 0.3 -0.4 0.5 0.2 -0.5
Tinnitus: Yes, now most or all of the time 0.9 1.0 2.5 -1.6 0.1 1.1 0.5
Commuting to job workplace: Public transport 0.3 0.3 0.7 0.0 0.8 -0.1 -0.8
Eye problems/disorders: Glaucoma 0.5 0.5 1.3 -1.1 0.4 0.6 0.6
Medication: Blood pressure 1.2 2.3 6.1 -2.5 0.0 1.7 -0.1
Pain type(s) experienced in last month: Hip pain 0.6 0.7 2.0 0.1 -0.9 0.1 1.4
Supplements: Fish oil (including cod liver oil) 3.0 3.9 8.0 2.7 -0.7 -2.8 -0.3
High cholesterol (Self-reported) 6.0 10.6 12.3 -2.9 3.5 3.2 -3.4
Medication: Bendroflumethiazide 1.7 2.5 4.4 -1.4 1.5 1.1 -2.1
Medication: Paracetamol 0.3 0.5 1.1 -0.3 -0.1 0.8 1.1
Medication: Lisinopril 0.8 1.0 2.2 0.9 -0.9 -0.4 1.5
Medication: Atorvastatin 4.7 5.9 8.7 -2.5 1.8 2.9 -2.2
Illnesses of father: High blood pressure 1.0 1.3 2.4 -1.0 1.2 0.5 -1.6
Alcohol drinker status: Never 0.8 0.9 1.7 1.0 0.7 -1.3 -0.6
Ever smoked 2.0 3.6 5.4 -1.6 1.8 2.3 -1.8
Basal metabolic rate 0.1 0.4 0.7 -0.8 0.1 0.9 -0.3
Leg fat percentage (left) 0.6 2.0 3.8 1.7 -0.6 -1.9 1.0
Arm fat-free mass (left) 0.1 0.3 0.7 -0.8 0.2 0.6 -0.4
Number of operations (self-reported) 1.1 1.6 3.1 0.2 1.5 1.0 -1.8
Average weekly beer plus cider intake 0.7 1.0 1.7 1.3 0.8 -0.9 -0.8
Irritability 2.4 4.0 7.4 -1.3 2.7 1.5 -2.2
Risk taking 2.7 4.0 4.5 2.1 -2.1 -1.8 2.0
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.6 1.3 -0.6 -1.0 0.2
Fractured/broken bones in last 5 years 0.1 0.1 0.3 0.3 0.5 -0.5 0.2
Age started oral contraceptive pill 1.5 1.9 5.3 1.3 -0.6 -2.3 0.4
Diastolic blood pressure, automated reading 0.7 2.0 4.3 -1.0 2.1 1.1 -1.2
Ever depressed for a whole week 0.3 0.4 0.7 -0.8 -0.2 0.4 0.8
Unable to work because of sickness or disability 2.4 3.1 6.7 -2.6 0.7 2.3 0.1
Commuting to job workplace: Cycle 1.3 1.6 4.0 1.4 -0.4 -2.0 -0.0
Myopia 0.2 0.3 0.5 -0.2 -0.7 0.2 0.7
Vascular/heart problems diagnosed by doctor 1.4 3.9 6.3 2.5 -1.5 -2.0 1.7
Cholesterol lowering medication 4.9 7.2 9.6 -3.1 2.5 3.0 -2.1
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.5 -0.4 1.0 0.7 -1.6
Pain experienced in last month 0.1 0.1 0.3 0.5 0.1 -0.0 0.4
Supplements: Calcium 0.1 0.1 0.3 -0.1 0.5 0.1 0.6
Basal cell carcinoma (self-reported) 0.4 0.5 1.4 -0.4 0.4 1.2 -0.3
Heart attack/myocardial infarction (self-reported) 1.5 2.0 3.3 -1.0 1.6 1.0 -1.8
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.5 -0.3 0.3 0.6 -0.7
Heart disease (siblings) 5.2 6.4 10.2 -3.2 2.5 2.6 -1.4
Alcohol drinker status: Previous 2.4 2.8 4.9 -1.2 -2.1 0.8 2.2
Pack years of smoking 0.7 1.1 1.8 -1.0 1.4 1.2 -0.3
Impedance of whole body 0.1 0.7 1.8 0.1 -0.9 -0.4 1.3
Leg fat mass (left) 0.2 0.8 1.1 0.9 -0.5 -1.0 1.0
Arm predicted mass (left) 0.1 0.3 0.8 -0.9 -0.0 0.6 -0.4