Hub : Genes

HEY1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1020	0.0330	5.5e-04	0.058	0.04	0.044	0.040	0.048	1.3e-07	1.0e-05	4.5e-06	1.2e-05	1.4e-06
2	GTEx	Brain Hypothalamus	0.2160	0.0820	4.7e-03	-0.004	NA	-0.002	NA	-0.011	4.0e-01	NA	3.7e-01	NA	7.1e-01
3	GTEx	Whole Blood	0.1230	0.0410	9.4e-05	0.023	NA	0.081	NA	0.087	3.3e-03	NA	6.0e-08	NA	2.1e-08
4	NTR	Blood	0.0575	0.0155	8.3e-08	0.028	0.03	0.036	0.036	0.038	1.6e-09	5.3e-10	9.4e-12	9.5e-12	2.3e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.9	1.4	2.6	-0.9	-1.4	1.6	-0.4
Bipolar Disorder or Schizophrenia	0.1	0.3	0.8	-0.9	0.2	0.6	0.1
Depressed Affect (Nagel 2018)	1.7	3.6	6.8	-0.7	1.1	2.6	2.4
Depression (Nagel 2018)	1.4	2.1	2.8	1.4	1.7	1.5	1.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	-0.5	-0.5	0.3	-1.0
Neuroticism (Nagel 2018)	1.0	2.4	6.3	-0.6	0.8	1.5	2.5
Schizophrenia (2018)	0.3	0.7	2.0	-0.4	1.4	-0.6	0.5
Schizophrenia vs Biploar Disorder	1.1	1.4	2.3	1.5	1.2	-1.2	0.6
Worry (Nagel 2018)	0.2	0.4	1.5	0.3	-0.2	0.1	1.2
Alzheimer’s Disease (in mother)	0.7	0.8	1.8	1.0	-1.3	-0.1	0.7
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.3	-0.7	0.4	0.8
Alzheimer’s Disease (including proxy)	0.4	0.5	1.4	0.0	-0.8	-0.3	1.2
Crohns Disease (2017)	0.3	0.7	1.6	-0.5	1.2	0.1	1.0
Irritable Bowel Disease (IBD)	0.2	0.5	1.7	-0.3	1.3	-0.2	0.5
Ulcerative Colitis (UC)	0.3	0.6	2.1	-0.3	1.4	-0.4	-0.2
Major Depression (MDD)	1.8	2.2	5.3	-0.6	2.3	1.7	0.4
Reaction Time	0.7	1.4	3.9	0.8	0.1	1.0	2.0
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.0	0.2	-0.8	-0.0	-1.0
Breast Cancer	0.5	1.1	2.3	-1.4	0.3	0.2	1.5
Ovarian Cancer	1.4	1.9	4.9	1.2	0.1	-2.2	-1.1
Prostate Cancer	0.4	0.5	1.5	0.1	-0.2	-1.2	0.7
Age at First Birth	2.5	3.6	7.6	-0.1	-2.8	-2.0	-1.8
Bipolar Disorder (2011)	0.9	0.9	2.2	-1.5	-0.7	0.9	0.1
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	-0.5	0.1	-1.0	-0.4
Coronary Artery Disease (CAD)	0.5	0.6	1.3	-0.2	1.1	-0.1	-0.9
Crohns Disease (2012)	0.2	0.3	1.0	-0.4	1.0	-0.0	0.2
Mean Putamen Volume	0.5	0.5	1.1	-0.6	0.8	0.2	1.1
Fasting Glucose	0.8	1.0	2.7	-1.6	1.1	0.4	-0.2
HbA1C	0.3	0.3	0.8	0.9	-0.2	-0.1	0.7
HDL Cholesterol	1.0	1.6	3.7	0.4	-0.6	1.5	1.9
LDL Cholesterol	0.7	1.1	3.1	-1.8	1.0	0.5	0.2
Lupus	0.3	0.4	1.0	-0.4	-1.0	0.6	0.4
Neuroticism (2016)	0.6	0.8	1.4	-0.3	0.8	-1.0	1.2
Primary Biliary Cirrhosis	0.2	0.2	0.5	-0.7	-0.1	0.6	-0.1
Rheumatoid Arthritis	0.6	0.9	2.4	-0.5	-1.6	-0.4	-0.8
Schizophrenia (2014)	0.1	0.2	0.6	0.0	0.7	0.2	0.5
Triglycerides	0.4	0.6	1.0	-1.0	0.7	-0.5	-0.7
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.4	-0.6	1.2	0.2	-0.7
Ulcerative Colitis	0.7	1.0	2.0	0.4	0.3	-1.4	-1.3
Blood Eosinophil Count	0.1	0.9	2.7	1.6	0.3	0.0	-0.9
Blood Platelet Count	0.1	1.1	4.1	-0.5	2.0	-0.2	-0.2
Blood Red Count	0.1	0.8	1.2	-1.1	-0.9	0.9	0.4
Blood White Count	0.2	1.2	2.3	-1.5	0.7	1.4	-0.1
Heel T-Score	1.2	9.2	32.7	-0.2	-5.7	1.4	-1.5
BMI	0.3	1.8	4.5	0.0	2.1	1.6	0.2
Height	0.2	3.4	8.5	-2.9	2.0	1.2	0.0
Waist Hip Ratio (WHR)	0.3	1.3	2.9	-1.1	0.9	0.4	1.7
Systolic Blood Pressure	0.4	2.1	5.1	2.3	-0.9	-0.7	-1.4
Smoking Status	0.5	1.3	1.7	-1.3	1.3	1.1	0.7
Allergy or Eczema	1.3	3.4	6.8	0.2	-2.6	-2.1	-1.5
Cardiovascular Disease	0.1	0.3	0.6	-0.1	-0.8	-0.1	-0.8
Hypothyroidism (self reported)	0.4	0.9	2.1	0.7	-0.7	-1.5	-0.7
Respiratory disease	1.0	2.3	5.5	2.3	-1.3	-0.8	-1.1
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.9	0.0	-0.3	-0.8	-1.7
Lung FEV1/FVC ratio	0.1	0.5	1.2	-0.7	1.1	-0.5	0.1
Lung FVC	0.4	2.1	6.7	0.9	-2.6	0.8	-0.3
Neuroticism	0.7	1.7	3.6	-0.9	0.8	1.3	1.9
Chronotype (morning person)	0.2	0.5	1.7	-1.3	0.2	0.6	-0.1
Hair Pigment	0.0	0.6	1.3	1.1	-0.1	0.8	-0.8
Tanning	0.1	1.8	2.6	-1.4	1.6	0.2	1.6
Hand grip strength (left)	1.1	2.8	7.2	-1.9	-2.7	0.7	0.4
Number of treatments/medications taken	1.0	1.7	6.0	0.9	2.5	0.2	-0.2
Average weekly spirits intake	0.1	0.1	0.5	0.1	0.7	-0.2	0.0
Sensitivity / hurt feelings	0.1	0.2	0.8	0.9	0.2	0.0	-0.2
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.6	1.3	1.6	0.4	0.4
Hearing difficulty/problems: Yes	0.3	0.4	1.1	0.6	-0.4	1.0	0.2
Relative age of first facial hair	0.6	1.1	2.2	0.8	0.6	-1.2	-1.5
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	10.1	0.0	3.2	-0.3	0.8
Ever used hormone-replacement therapy (HRT)	1.3	1.6	4.8	2.2	-0.6	-1.1	-0.1
Ever had hysterectomy (womb removed)	0.7	0.8	1.1	0.9	0.3	1.1	1.0
Systolic blood pressure, automated reading	0.5	1.3	4.6	2.1	-0.1	0.9	0.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.6	-0.8	-0.7	-0.8	-0.2
Angina	0.4	0.5	0.8	0.6	-0.1	-0.9	-0.9
Medication for hormone replacement therapy	0.6	0.6	1.7	-0.1	0.6	1.3	0.7
Vitamin and mineral supplements	0.6	0.9	1.5	-0.7	-1.2	1.2	0.3
Supplements: Zinc	0.5	0.5	1.8	0.2	-1.3	-0.3	0.4
Medication: Co-codamol	0.6	0.7	1.1	0.9	1.1	0.7	0.6
Medication: Metformin	0.8	1.1	1.5	1.1	0.8	-1.1	-1.2
Diabetes (father)	0.1	0.1	0.3	-0.3	-0.5	-0.3	0.3
Diabetes (mother)	0.1	0.2	0.5	-0.4	0.7	0.1	-0.3
Severe depression (siblings)	1.1	1.3	2.7	0.9	1.6	1.2	0.1
Pack years adult smoking proportion	0.3	0.4	0.9	0.4	0.9	-0.4	-0.6
Impedance of leg (right)	0.1	0.4	1.2	-0.1	-0.6	1.1	-0.0
Leg fat-free mass (left)	0.2	1.2	3.9	-0.8	2.0	0.3	-0.2
Trunk fat percentage	1.0	4.0	12.9	-0.5	3.6	1.7	0.1
Hand grip strength (right)	1.3	3.5	10.5	-1.6	-3.2	0.9	0.0
Townsend deprivation index at recruitment	0.4	0.6	2.2	0.2	1.5	-0.5	0.0
Current tobacco smoking	0.1	0.2	0.4	0.4	0.5	-0.6	0.1
Average weekly fortified wine intake	2.3	2.7	7.9	-1.7	-0.3	-0.1	2.8
Maternal smoking around birth	0.8	1.2	3.3	0.2	1.8	-0.8	0.9
Fed-up feelings	0.3	0.5	1.3	-0.0	1.2	0.9	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.4	1.8	1.4	0.2	0.9
Relative age voice broke	0.1	0.1	0.3	0.2	0.3	-0.1	-0.6
Taking other prescription medications	0.8	1.3	1.9	1.4	1.3	-1.0	-0.6
Age when periods started (menarche)	0.5	1.2	3.6	1.9	-0.5	-0.8	-0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	-0.2	0.6	-0.5	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.2	-0.7	-1.5	0.9	-1.0
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.7	-0.7	-0.8	-1.0	-1.3
Qualifications: CSEs or equivalent	0.4	0.6	1.2	-0.9	-0.5	0.4	-1.1
Serious illness, injury or assault to yourself	1.0	1.2	2.0	0.8	-0.5	-1.4	-1.4
High blood pressure	0.2	0.6	1.4	0.8	0.1	-0.5	-1.2
Hayfever, allergic rhinitis or eczema	1.8	3.8	10.0	-0.2	-3.2	-1.7	-1.5
Multivitamins +/- minerals	1.2	1.5	3.7	0.2	1.9	-1.5	-0.4
Stomach or abdominal pain in last month	0.5	0.7	1.6	-0.5	0.3	-0.8	-1.3
Supplements: Glucosamine	1.0	1.3	4.3	-1.0	2.1	0.2	-0.0
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.2	0.7	1.0	-1.5	-1.3
Medication: Atenolol	0.5	0.6	2.0	0.6	-0.2	-1.4	-0.4
Medication: Levothyroxine sodium	1.0	1.7	2.8	1.7	0.1	-1.4	-1.4
Sitting height	0.2	1.5	3.8	-2.0	1.2	0.5	0.5
Chronic bronchitis/emphysema (father)	0.3	0.4	0.9	0.1	0.7	-1.0	0.0
High blood pressure (mother)	0.7	1.0	2.2	-0.8	-1.0	1.5	-0.2
Body mass index (BMI)	0.6	2.7	9.0	0.4	3.0	1.3	-0.0
Impedance of leg (left)	0.2	0.8	2.5	-0.4	-0.7	1.6	0.2
Leg predicted mass (left)	0.2	1.2	4.3	-0.7	2.1	0.3	-0.2
Trunk fat mass	1.0	4.2	13.2	-0.7	3.6	1.7	0.1
Waist circumference	0.9	3.3	10.4	-0.4	3.2	1.5	0.7
Number of incorrect matches in round	2.3	3.8	8.6	2.9	1.7	-1.6	-1.0
Past tobacco smoking	0.8	1.5	3.1	1.5	-1.8	-0.6	-0.5
Alcohol usually taken with meals	0.7	1.1	2.1	0.0	-1.2	1.4	-1.0
Nervous feelings	0.5	0.9	2.0	-0.6	-1.4	0.6	1.0
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.9	5.8	2.4	2.2	-0.0	0.8
Hearing difficulty/problems with background noise	0.7	1.2	3.3	-0.2	0.2	1.8	1.1
Hair/balding pattern: Pattern 2	0.8	1.1	2.8	-0.7	-0.1	1.7	1.0
Had menopause	1.4	1.8	2.9	0.4	1.5	1.7	1.4
Had other major operations	0.5	0.6	1.0	-0.8	0.5	1.0	-0.8
Forced vital capacity (FVC)	0.4	1.7	4.7	-0.8	-2.2	1.2	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.0	-1.1	-1.4	1.1	-0.8
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	4.4	2.0	1.9	-2.1	-1.0
Qualifications: None of the above	0.7	1.4	2.5	1.6	1.3	-1.1	-0.5
Financial difficulties in last 2 years	0.4	0.5	0.9	-0.5	0.9	-0.9	-0.2
Mouth/teeth dental problems	0.9	1.4	2.2	1.2	-1.0	-1.0	-1.5
Heart attack	1.6	2.0	3.6	1.3	-1.0	-1.9	-1.4
Allergy	1.9	4.3	9.6	-0.8	3.1	1.8	1.9
Pain all over the body in last month	0.9	1.0	1.7	0.3	-1.3	-0.9	1.2
Diabetes (self-reported)	0.9	1.4	2.8	0.6	0.2	-1.7	-1.5
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.1	-0.6	-0.9	-1.8	-0.7
Medication: Ramipril	2.2	2.8	4.5	1.3	-2.1	-1.1	-2.0
Medication: Simvastatin	0.3	0.4	1.3	-0.2	1.1	0.2	-0.7
Fluid intelligence score	0.1	0.3	0.5	0.2	-0.7	0.5	-0.6
Illnesses of siblings	0.9	1.2	1.8	-1.3	-1.2	0.3	1.3
Neuroticism score	0.5	1.1	2.0	-1.0	0.0	1.1	1.4
Weight	0.8	3.7	12.0	-0.6	3.5	1.6	0.0
Impedance of arm (right)	0.1	0.4	0.7	-0.9	-0.5	-0.0	0.7
Arm fat percentage (right)	0.7	2.8	9.7	0.3	3.1	1.2	-0.1
Trunk fat-free mass	0.1	0.7	2.0	-0.5	1.4	0.3	-0.7
Hip circumference	0.7	2.9	9.4	0.1	3.1	1.3	-0.7
Time employed in main current job	0.9	1.1	2.5	-1.0	-0.5	0.8	1.6
Alcohol intake versus 10 years previously	1.4	2.1	5.0	2.2	1.7	0.2	-0.8
Father’s age at death	0.4	0.6	0.9	-0.8	1.0	0.9	-0.2
Worrier / anxious feelings	0.0	0.0	0.0	0.0	-0.2	-0.0	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	3.0	1.1	1.7	-0.4	0.7
Falls in the last year	0.5	0.6	1.5	0.5	-0.2	1.2	0.8
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.4	0.3	-0.4	-0.2
Number of live births	0.3	0.4	0.8	0.7	-0.9	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	7.0	-0.6	-2.6	0.9	-0.4
Pulse rate	0.7	1.1	2.6	-0.1	-0.6	-1.2	-1.6
Happiness	0.1	0.1	0.3	-0.6	-0.0	0.0	-0.3
Noisy workplace	0.4	0.5	1.1	-0.7	-0.2	-0.4	-1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.4	-1.5	-1.2	0.7	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.2	0.6	-0.5	-0.5
Mouth/teeth dental problems: Dentures	1.0	1.6	3.9	-0.3	0.9	2.0	1.3
Asthma	1.3	2.5	3.9	1.6	-2.0	-0.8	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.7	1.3	-0.2	-0.1	0.8
Medication: Cholesterol lowering	0.8	1.3	2.7	0.9	1.0	-0.8	-1.7
Depression (self-reported)	0.7	0.8	1.5	-1.0	1.2	0.8	0.3
Medication: Lansoprazole	1.4	1.6	2.3	1.1	-1.3	-1.2	-1.5
Prospective memory result	0.3	0.4	0.9	-0.3	1.0	-0.5	-0.3
Lung cancer (father)	0.1	0.1	0.3	-0.2	0.2	0.6	0.4
Illnesses of mother	0.2	0.2	0.8	0.2	0.3	-0.9	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	5.1	-1.1	-2.3	0.8	-1.0
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.0	-0.1	0.5	0.7
Impedance of arm (left)	0.2	0.8	2.1	-1.4	-0.2	0.2	1.0
Arm fat mass (right)	0.7	3.0	10.3	-0.1	3.2	1.3	-0.2
Trunk predicted mass	0.1	0.7	2.0	-0.5	1.4	0.4	-0.7
Standing height	0.2	1.7	4.4	-2.1	1.4	0.7	0.0
Length of working week for main job	2.0	2.2	2.7	1.2	1.7	-1.6	-1.5
Exposure to tobacco smoke at home	1.9	2.1	4.2	0.2	1.8	-2.1	-1.0
Breastfed as a baby	0.3	0.4	1.0	-0.0	1.0	-0.1	-0.8
Tense / ‘highly strung’	0.7	1.1	4.1	-0.4	-0.5	0.0	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.3	0.5	0.8	-0.1
Hair/balding pattern: Pattern 4	0.8	2.0	3.8	2.0	0.8	-1.9	-0.4
Birth weight of first child	0.4	0.8	1.9	1.4	-1.0	-0.6	-0.3
Peak expiratory flow (PEF)	1.1	2.5	8.9	0.3	-3.0	0.8	-0.7
Pulse wave reflection index	0.4	0.5	1.2	1.1	0.4	0.3	0.7
Ever highly irritable/argumentative for 2 days	1.1	1.4	2.3	0.9	1.4	-1.5	-0.7
Loud music exposure frequency	1.8	2.0	5.7	1.0	-0.3	-2.4	-1.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	0.3	-0.9	0.0	0.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.5	-1.2	-0.3	-0.1	0.9
Blood clot in the leg (DVT)	0.7	0.8	2.2	0.5	0.4	-1.5	-0.9
Medication: Paracetamol	1.1	1.9	4.2	-1.1	2.0	-0.2	1.5
Headache pain in last month	0.4	0.6	1.0	0.8	1.0	-0.4	-0.8
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	4.4	-1.9	-0.6	1.6	2.1
Glaucoma (self-reported)	2.0	2.4	3.6	1.5	0.7	-1.9	-1.8
Gout (self-reported)	0.8	1.1	3.0	1.7	-0.9	-0.8	-0.3
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.2	0.9	-0.1	-1.5	-1.2
Medication: Amlodipine	1.4	1.9	3.9	0.8	1.3	-1.2	-2.0
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.7	1.3	-0.5	0.0	-0.7
Birth weight	1.3	2.7	4.9	0.6	-1.9	-1.4	-2.2
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.0	-0.6	1.4	0.6	0.3
High blood pressure (siblings)	0.9	1.4	2.7	1.7	0.2	-0.7	-1.5
Forced vital capacity (FVC), Best measure	0.4	1.4	3.5	-1.1	-1.9	0.8	-0.6
Body fat percentage	0.9	3.7	11.9	-0.1	3.5	1.7	-0.1
Leg fat percentage (right)	1.1	3.9	11.3	0.2	3.4	2.1	-0.2
Arm fat-free mass (right)	0.2	1.2	2.4	-0.7	1.6	1.2	-0.6
Exposure to tobacco smoke outside home	1.1	1.5	4.8	-0.4	2.2	0.2	-0.9
Comparative body size at age 10	0.4	1.0	3.8	-0.4	-2.0	-0.2	0.1
Number of full brothers	1.5	1.9	7.3	0.5	2.7	-0.3	-0.1
Worry too long after embarrassment	0.6	1.1	3.7	-0.8	0.1	0.2	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.6	0.2	1.9	1.6	0.8
Wheeze or whistling in the chest in last year	0.3	0.6	1.7	1.3	-0.0	-0.7	0.1
Number of children fathered	0.8	0.9	3.5	0.3	1.9	0.1	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.8	-0.3	1.0	0.7	-1.9
Age at first live birth	0.8	1.4	3.8	-2.0	-1.0	-0.1	-0.8
Pulse wave peak to peak time	0.1	0.2	0.4	-0.1	0.3	-0.3	-0.6
Health satisfaction	0.2	0.2	0.5	0.7	-0.2	0.3	0.4
Shortness of breath walking on level ground	1.0	1.1	2.2	0.8	-0.3	-1.5	-1.2
Qualifications: College or University degree	0.3	1.1	3.5	-1.9	-0.8	0.0	0.3
Eye problems/disorders: None of the above	0.9	1.1	2.5	-0.9	-1.6	0.9	0.4
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.0	-0.1	-0.9	-2.0	-0.2
Emphysema/chronic bronchitis	1.1	1.3	4.4	0.2	-0.8	0.2	2.1
Medication for pain relief, constipation, heartburn	1.1	1.9	5.2	-0.8	-2.3	1.1	-0.8
Neck or shoulder pain in last month	0.6	0.8	2.3	1.5	0.1	-0.1	-1.0
Medication: Blood pressure	1.0	1.8	4.6	2.1	0.1	-1.3	-1.1
Angina (self-reported)	0.4	0.5	0.9	0.7	-0.3	-1.0	-0.7
Migraine (self-reported)	1.2	1.5	3.0	-0.7	-1.6	-0.3	1.7
Medication: Ibuprofen	0.5	0.6	1.3	1.1	-0.8	0.2	0.6
Medication: Allopurinol	0.4	0.6	1.1	1.1	-0.9	-0.5	0.2
Medication: Omeprazole	0.9	1.0	1.7	1.0	1.3	1.0	0.7
Medication: Seretide 50 evohaler	0.6	0.6	1.5	0.9	1.2	-0.6	0.0
Mean time to correctly identify matches	0.4	0.7	2.4	1.6	0.1	0.2	0.5
Heart disease (mother)	0.8	1.0	1.9	0.1	1.4	0.9	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.3	3.9	6.9	1.9	-0.4	-2.2	-2.6
Whole body fat mass	0.9	3.7	12.4	-0.2	3.5	1.5	-0.1
Leg fat mass (right)	1.2	4.5	14.4	-0.2	3.8	1.9	-0.1
Arm predicted mass (right)	0.3	1.3	2.6	-0.8	1.6	1.4	-0.4
Pulse rate, automated reading	0.6	1.9	4.1	-2.0	-0.9	1.6	-0.3
Alcohol intake frequency.	0.8	1.8	5.1	1.4	2.3	-0.1	-0.0
Comparative height size at age 10	0.1	0.7	1.9	-1.4	0.9	-0.3	-0.3
Number of full sisters	0.3	0.3	0.9	-0.4	0.0	-1.0	0.5
Suffer from ‘nerves’	0.3	0.5	1.5	-0.3	0.6	0.3	1.2
Overall health rating	0.4	0.8	0.8	0.9	0.8	-0.9	-0.9
Chest pain or discomfort	0.8	1.1	2.6	0.9	-1.0	-0.1	1.6
Had major operations	0.5	0.6	1.5	1.2	0.7	0.2	0.5
Age at last live birth	0.6	0.9	2.1	-1.4	-1.0	0.3	-0.7
Family relationship satisfaction	1.0	1.3	2.3	1.4	-0.5	-1.5	-0.8
Leg pain on walking	0.5	0.7	1.9	1.4	-0.1	-0.9	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.9	3.6	-0.8	1.4	1.2	1.9
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.6	1.3	-0.7	1.2	0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.8	0.9	-0.3	0.9	0.8
Medication: Aspirin	0.5	0.7	1.1	1.0	0.4	-1.1	-0.6
Supplements: Vitamin C	0.4	0.4	1.2	-1.1	0.2	0.6	0.4
Knee pain experienced in last month	1.2	1.8	5.8	1.0	2.4	-0.0	0.7
Hypertension (Self-reported)	0.2	0.7	1.7	0.9	0.3	-0.3	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	0.5	-0.4	0.6	-0.8
Illnesses of father: Heart disease	2.1	2.9	4.2	-2.1	-1.1	1.4	2.0
Illnesses of siblings: Diabetes	0.0	0.0	0.1	0.2	-0.1	0.1	-0.2
Smoking status: Previous	0.5	0.8	1.7	-1.3	0.8	0.8	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.1	-1.8	-1.1	0.9	0.3
Whole body fat-free mass	0.1	0.8	2.7	-0.6	1.6	0.4	-0.5
Leg fat-free mass (right)	0.2	1.0	3.0	-0.9	1.7	0.4	-0.0
Arm fat percentage (left)	0.7	2.7	9.3	0.0	3.0	1.3	0.1
Average weekly red wine intake	1.0	1.4	3.3	-1.8	0.9	1.0	0.8
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	0.7	0.0	-0.7	-0.1
Mood swings	1.9	3.4	5.6	-1.6	1.5	2.4	1.8
Loneliness, isolation	0.5	0.6	1.4	0.3	0.4	1.2	0.9
Long-standing illness, disability or infirmity	1.7	2.6	9.7	0.3	3.1	-0.1	0.8
Ever had bowel cancer screening	0.7	0.8	2.3	0.8	0.3	-0.4	-1.5
Diabetes diagnosed by doctor	1.2	2.0	5.9	0.8	-0.3	-1.2	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.1	0.6	0.6	1.0	-0.2
Friendships satisfaction	1.2	1.5	2.9	1.2	-0.1	-1.7	-1.4
Qualifications: nursing, teaching	0.7	1.1	4.0	-0.4	-2.0	0.5	-0.2
Commuting to job workplace: Walk	0.3	0.3	0.8	0.0	0.2	0.6	-0.9
Eye problems/disorders: Cataract	2.4	2.8	4.9	1.9	2.2	-1.0	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.4	-0.5	1.4	0.8	1.6
Medication for cholesterol	0.3	0.4	1.0	-0.8	-1.0	-0.2	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	5.3	0.4	2.3	-0.2	-0.8
Back pain experienced in last month	0.6	0.8	2.5	0.8	1.6	-0.4	-0.2
Mineral and other dietary supplements	1.4	1.9	7.2	0.5	-2.7	-0.4	-0.2
Breast cancer (self-reported)	1.7	2.0	2.6	1.2	1.4	-1.6	-1.4
Asthma (self-reported)	1.1	2.3	3.5	1.7	-1.6	-0.6	-1.9
Osteoporosis (self-reported)	0.4	0.5	1.4	0.5	1.2	0.5	0.0
Osteoarthritis (self-reported)	1.8	2.4	5.7	0.4	2.4	-1.4	-1.3
Medication: Aspirin	0.8	1.0	1.7	1.3	0.4	-1.3	-0.7
Medication: Gliclazide	0.7	0.8	1.8	-0.6	0.0	-1.0	-1.4
Illnesses of father: None of the above (group 1)	1.0	1.2	2.4	1.6	1.4	0.3	-0.7
Smoking status: Current	0.3	0.5	1.3	0.6	0.5	-1.1	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	3.8	1.2	-1.3	0.2	-1.9
Whole body water mass	0.2	0.9	2.6	-0.6	1.6	0.4	-0.7
Leg predicted mass (right)	0.2	0.9	2.8	-0.8	1.7	0.3	-0.1
Arm fat mass (left)	0.7	3.0	10.1	-0.2	3.2	1.3	-0.1
Number of self-reported non-cancer illnesses	0.9	1.5	5.8	0.2	2.4	0.1	-0.2
Average weekly champagne plus white wine intake	2.7	3.7	7.6	-2.8	-1.6	2.1	0.1
Miserableness	0.3	0.5	0.9	-0.5	0.8	1.0	0.6
Guilty feelings	0.5	0.7	1.6	-0.5	-0.3	1.2	1.0
Wears glasses or contact lenses	0.2	0.2	0.6	-0.8	0.0	-0.0	0.4
Ever taken oral contraceptive pill	3.2	3.5	13.9	-0.4	0.0	0.2	-3.7
Hearing aid user	0.8	0.9	3.0	-0.8	0.2	-0.1	-1.7
Mother’s age at death	0.6	0.7	2.5	-1.6	-0.1	0.3	-0.4
Financial situation satisfaction	0.6	0.8	2.1	0.6	-0.3	-1.5	-0.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.6	0.1	0.8	0.6	0.7
Commuting to job workplace: Public transport	1.2	1.5	5.8	-2.4	0.1	-0.2	0.2
Eye problems/disorders: Glaucoma	1.2	1.4	3.2	1.5	-0.0	-1.8	-0.6
Medication: Blood pressure	0.5	1.0	1.8	0.2	0.9	-1.1	-1.3
Pain type(s) experienced in last month: Hip pain	2.5	3.1	10.2	-0.1	3.2	1.1	1.0
Supplements: Fish oil (including cod liver oil)	1.1	1.5	2.7	-0.6	1.6	0.9	1.4
High cholesterol (Self-reported)	0.6	1.0	3.7	-0.1	1.9	0.4	0.3
Medication: Bendroflumethiazide	1.6	2.4	6.7	0.9	0.2	-2.6	-1.4
Medication: Paracetamol	1.9	2.9	8.8	-0.9	3.0	-0.1	1.4
Medication: Lisinopril	0.5	0.7	1.8	1.3	0.5	-0.3	-0.7
Medication: Atorvastatin	0.8	1.0	2.1	0.4	-1.4	-1.3	0.0
Illnesses of father: High blood pressure	1.8	2.2	7.2	0.5	-2.7	-0.4	-1.1
Alcohol drinker status: Never	0.6	0.7	1.2	1.0	-0.3	-1.1	-0.7
Ever smoked	0.3	0.5	1.0	-1.0	0.9	0.3	0.4
Basal metabolic rate	0.3	1.4	4.5	-0.7	2.1	0.7	-0.4
Leg fat percentage (left)	1.0	3.7	10.1	0.2	3.2	2.1	-0.2
Arm fat-free mass (left)	0.3	1.4	4.2	-0.3	2.1	0.6	-1.0
Number of operations (self-reported)	0.7	1.0	2.6	-0.3	1.6	1.2	0.1
Average weekly beer plus cider intake	0.2	0.4	0.8	0.9	-0.3	-0.3	-0.6
Irritability	0.6	1.1	2.1	-1.4	1.0	0.1	1.1
Risk taking	0.1	0.2	0.3	-0.5	-0.5	0.4	0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	0.3	0.1	-0.1	0.4
Fractured/broken bones in last 5 years	1.4	1.8	4.1	0.6	2.0	-1.6	-0.2
Age started oral contraceptive pill	0.7	0.9	3.2	0.6	1.8	0.1	0.4
Diastolic blood pressure, automated reading	0.3	1.0	1.7	0.8	-1.1	1.3	-0.5
Ever depressed for a whole week	1.7	2.1	4.6	2.1	1.0	-1.2	-1.2
Unable to work because of sickness or disability	1.0	1.2	3.5	0.8	-0.1	0.9	1.9
Commuting to job workplace: Cycle	1.4	1.7	6.1	-2.5	0.2	0.3	0.7
Myopia	0.5	0.8	1.7	0.4	0.3	-1.1	-1.3
Vascular/heart problems diagnosed by doctor	0.5	1.2	2.6	-1.1	-0.3	1.1	1.6
Cholesterol lowering medication	0.6	0.8	2.0	-0.3	0.8	1.4	0.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.5	0.9	1.2	0.3	0.5
Pain experienced in last month	0.5	0.9	1.7	-1.3	-1.3	-0.2	0.3
Supplements: Calcium	0.5	0.5	1.0	-0.9	0.4	-0.0	-1.0
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	1.1	-0.1	-0.6	-0.5
Heart attack/myocardial infarction (self-reported)	1.4	1.8	3.3	1.2	-0.9	-1.8	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.7	0.5	0.5	-1.3	-0.6
Heart disease (siblings)	1.0	1.2	2.4	1.3	1.6	-0.3	-0.8
Alcohol drinker status: Previous	2.3	2.6	6.2	-0.1	1.4	1.6	2.5
Pack years of smoking	0.4	0.6	1.8	0.5	1.3	-0.2	-0.6
Impedance of whole body	0.1	0.5	0.8	-0.9	-0.6	0.7	0.6
Leg fat mass (left)	1.0	3.8	11.7	-0.1	3.4	1.9	-0.2
Arm predicted mass (left)	0.3	1.6	4.7	-0.3	2.2	0.8	-1.1