Hub : Genes

HHAT

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3100	0.0420	0.0e+00	0.200	0.243	0.251	0.257	0.237	7.1e-24	3.0e-29	3.0e-30	4.7e-31	1.9e-28
2	GTEx	Esophagus Mucosa	0.0950	0.0410	8.5e-03	0.119	NA	0.059	NA	0.096	2.6e-08	NA	8.2e-05	NA	5.8e-07
3	GTEx	Nerve Tibial	0.1969	0.0527	5.3e-06	0.011	NA	0.112	NA	0.096	5.5e-02	NA	2.8e-08	NA	2.6e-07
4	TCGA	Prostate Adenocarcinoma	0.0651	0.0271	2.9e-03	0.000	0.019	0.009	NA	0.004	3.3e-01	3.8e-03	3.6e-02	NA	1.2e-01
5	TCGA	Thyroid Carcinoma	0.0620	0.0280	9.6e-03	0.052	0.030	0.063	NA	0.064	8.1e-06	5.9e-04	8.6e-07	NA	8.4e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.4	0.8	-0.9	0.7	-0.4	-0.7	-0.4
Bipolar Disorder or Schizophrenia	0.3	0.9	3.0	-0.9	-0.2	-0.4	-1.7	-0.5
Depressed Affect (Nagel 2018)	0.4	0.8	2.4	1.6	0.9	0.6	-0.2	-0.7
Depression (Nagel 2018)	0.7	1.1	3.2	1.8	0.9	-0.3	-0.2	-1.1
Intelligence (Savage-Jansen 2018)	1.6	5.0	9.1	2.4	1.1	3.0	2.3	1.9
Neuroticism (Nagel 2018)	0.8	1.9	4.5	1.4	1.0	1.5	-2.1	-0.2
Schizophrenia (2018)	0.4	0.8	2.9	-0.4	-0.9	-0.2	-1.7	-0.4
Schizophrenia vs Biploar Disorder	0.4	0.5	2.2	0.3	-1.5	-0.0	-0.1	-0.2
Worry (Nagel 2018)	1.0	2.2	10.2	-0.3	-0.4	0.5	-3.2	-0.4
Alzheimer’s Disease (in mother)	0.5	0.6	2.1	0.4	0.6	0.6	0.1	1.5
Alzheimer’s Disease (in father)	2.3	2.5	8.8	-0.8	-0.8	0.5	-1.5	3.0
Alzheimer’s Disease (including proxy)	1.9	2.8	10.0	0.0	-0.2	0.8	-1.7	3.2
Crohns Disease (2017)	0.6	1.4	3.7	-1.9	-1.1	-1.0	-0.3	-1.0
Irritable Bowel Disease (IBD)	0.1	0.4	0.6	-0.6	-0.8	-0.5	-0.2	-0.7
Ulcerative Colitis (UC)	0.2	0.3	1.0	0.7	-0.2	0.4	-1.0	0.1
Major Depression (MDD)	0.2	0.3	0.7	-0.9	-0.6	0.6	-0.3	-0.1
Reaction Time	2.1	4.1	6.7	-2.3	-2.5	1.0	-2.6	1.0
Verbal and Numeric Reasoning (VNR)	1.2	2.9	5.9	1.9	1.2	2.4	0.5	1.8
Breast Cancer	1.0	2.3	7.6	-0.5	-1.4	-0.1	-1.3	2.8
Ovarian Cancer	0.2	0.3	1.3	0.4	0.3	0.2	1.1	-0.0
Prostate Cancer	0.1	0.1	0.3	0.2	0.2	-0.0	-0.5	0.4
Age at First Birth	2.0	2.9	6.4	2.5	0.7	1.4	-0.4	2.3
Bipolar Disorder (2011)	1.5	1.4	5.5	-0.1	-1.0	-0.8	-2.3	0.1
Body Mass Index (BMI) (2010)	0.9	1.2	2.2	-1.3	-1.2	-1.5	-0.8	-0.3
Coronary Artery Disease (CAD)	0.7	0.9	2.6	1.2	-0.0	-0.6	0.3	-1.6
Crohns Disease (2012)	0.4	0.7	2.5	-0.1	-0.4	-0.5	0.6	-1.6
Mean Putamen Volume	0.6	0.7	2.8	-0.2	-0.3	0.1	-0.7	1.7
Fasting Glucose	0.7	0.8	2.7	-1.6	-0.3	-0.8	0.9	0.0
HbA1C	0.2	0.3	0.9	0.1	-0.9	-0.3	0.6	-0.1
HDL Cholesterol	1.2	2.0	4.3	1.9	0.5	1.3	-0.7	2.1
LDL Cholesterol	0.2	0.3	0.7	0.8	-0.3	-0.0	0.2	-0.8
Lupus	0.1	0.2	0.4	-0.7	0.3	-0.4	0.0	-0.3
Neuroticism (2016)	0.6	0.8	1.8	-1.1	0.2	1.0	-1.4	-0.5
Primary Biliary Cirrhosis	0.4	0.6	2.2	1.5	-0.8	0.2	0.4	-0.1
Rheumatoid Arthritis	1.9	2.6	6.4	-1.9	-1.7	-2.5	0.2	-0.4
Schizophrenia (2014)	0.2	0.5	2.0	-0.2	-0.7	0.1	-1.4	-0.3
Triglycerides	0.6	1.1	2.8	-0.9	-0.7	-0.5	1.0	-1.7
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.4	0.1	0.2	-0.0	0.6	-1.2
Ulcerative Colitis	0.3	0.5	0.6	0.8	-0.5	0.8	-0.7	0.6
Blood Eosinophil Count	0.0	0.1	0.1	-0.4	0.1	-0.2	-0.2	-0.3
Blood Platelet Count	0.1	1.1	3.3	-1.8	-1.4	0.1	-0.7	-0.3
Blood Red Count	0.2	2.3	4.9	-0.7	1.2	-2.2	2.1	-0.8
Blood White Count	0.4	3.0	8.1	-0.3	-0.4	-1.2	2.9	-2.3
Heel T-Score	1.3	10.5	45.6	-0.2	-0.9	-2.1	-1.3	-6.8
BMI	0.5	2.8	6.9	0.9	2.1	-1.0	2.6	0.9
Height	0.3	4.9	10.6	0.8	2.4	-0.2	2.7	-3.3
Waist Hip Ratio (WHR)	0.3	1.4	2.9	1.2	-0.3	0.9	1.3	-1.7
Systolic Blood Pressure	1.3	6.6	11.0	-1.5	-2.0	-2.6	3.3	-3.0
Smoking Status	2.2	5.4	20.4	1.0	0.9	0.6	2.1	-4.5
Allergy or Eczema	0.2	0.6	1.3	-0.5	0.7	0.1	-1.2	-0.9
Cardiovascular Disease	1.8	6.1	15.1	-0.4	1.3	-1.4	3.4	-3.9
Hypothyroidism (self reported)	1.0	2.3	5.6	1.0	1.9	0.3	1.0	-2.4
Respiratory disease	0.5	1.1	2.1	-1.0	-0.5	-0.5	-1.3	-1.4
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.7	0.2	-0.2	-0.5	0.8	-0.5
Lung FEV1/FVC ratio	0.2	0.8	2.0	0.5	1.4	0.5	0.9	-0.7
Lung FVC	0.8	4.1	14.0	1.7	0.9	-1.2	-1.2	-3.7
Neuroticism	0.9	2.1	8.1	0.7	0.1	1.0	-2.8	0.9
Chronotype (morning person)	0.8	1.8	5.6	0.2	-1.3	-0.0	-1.1	2.4
Hair Pigment	0.0	0.5	0.8	-0.5	-0.9	-0.6	-0.9	0.5
Tanning	0.1	1.6	6.2	0.2	0.3	-0.3	1.1	-2.5
Hand grip strength (left)	0.3	0.9	1.7	0.8	0.5	-0.9	1.0	-1.3
Number of treatments/medications taken	2.5	4.4	13.7	-0.5	1.9	-0.6	3.7	-2.1
Average weekly spirits intake	0.8	1.0	2.1	-0.5	-1.5	-1.2	-0.2	1.0
Sensitivity / hurt feelings	0.7	1.1	2.1	1.1	0.2	1.5	-0.9	-1.2
Frequency of depressed mood in last 2 weeks	1.7	2.3	5.1	2.2	2.0	0.4	-0.2	-1.6
Hearing difficulty/problems: Yes	0.6	0.9	2.7	0.4	-0.1	1.1	-1.6	0.5
Relative age of first facial hair	0.5	1.0	2.4	1.6	0.5	1.4	0.4	-0.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.2	0.9	1.8	0.7	0.1	0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	0.1	0.3	-0.6	-0.6	-0.0
Ever had hysterectomy (womb removed)	0.9	1.1	4.3	-0.7	-0.6	-2.1	-0.0	-0.5
Systolic blood pressure, automated reading	1.9	5.4	7.7	-2.8	-2.5	-2.7	2.4	-0.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.9	-0.9	-0.0	-0.0	-0.4	-0.0
Angina	1.5	2.0	4.3	0.5	0.7	-1.1	2.1	-1.9
Medication for hormone replacement therapy	0.3	0.4	0.9	0.7	0.6	-1.0	0.1	0.3
Vitamin and mineral supplements	1.0	1.3	3.2	-1.4	1.0	-0.6	-0.1	-1.8
Supplements: Zinc	3.2	3.5	10.6	-0.7	-1.4	1.0	-3.3	1.9
Medication: Co-codamol	2.2	2.5	5.3	0.6	0.2	-2.3	1.9	-1.8
Medication: Metformin	1.4	1.9	4.5	1.3	1.2	0.7	1.2	-2.1
Diabetes (father)	1.5	1.8	4.5	-0.1	-0.3	-2.1	0.5	-2.0
Diabetes (mother)	0.7	0.9	2.1	0.3	0.4	1.2	-0.9	1.5
Severe depression (siblings)	0.7	0.7	1.0	1.0	0.5	1.0	0.9	-0.7
Pack years adult smoking proportion	1.0	1.5	5.3	-0.2	0.3	-1.4	2.3	-0.6
Impedance of leg (right)	0.7	3.3	12.9	1.7	-0.2	0.7	0.5	-3.6
Leg fat-free mass (left)	0.2	1.2	2.4	-1.2	1.6	-0.7	0.9	1.1
Trunk fat percentage	0.6	2.4	8.8	-0.6	1.5	-0.6	3.0	0.2
Hand grip strength (right)	0.7	1.8	4.7	0.9	1.4	-0.5	1.1	-2.2
Townsend deprivation index at recruitment	0.3	0.4	1.1	0.7	-0.3	0.7	-1.1	0.2
Current tobacco smoking	1.5	2.5	8.2	-0.4	0.0	-0.5	1.9	-2.9
Average weekly fortified wine intake	0.3	0.3	0.6	-0.4	-0.8	-0.3	0.8	-0.0
Maternal smoking around birth	1.1	1.6	2.7	0.6	1.5	0.2	1.6	-1.6
Fed-up feelings	0.9	1.6	3.2	1.8	1.1	-0.5	1.5	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	5.5	2.3	1.7	0.3	0.7	-1.6
Relative age voice broke	0.2	0.3	0.4	0.4	-0.6	0.5	-0.6	-0.4
Taking other prescription medications	1.8	2.8	5.9	0.2	2.4	0.5	2.2	-1.8
Age when periods started (menarche)	1.6	3.7	7.9	2.1	1.0	0.6	2.8	-2.3
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	2.8	1.4	0.9	1.2	0.9	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	3.1	0.6	0.3	0.3	0.1	-1.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.8	0.4	0.3	-0.6	1.0	-1.4
Qualifications: CSEs or equivalent	0.5	0.6	1.6	-0.2	1.3	0.6	-0.7	0.7
Serious illness, injury or assault to yourself	0.4	0.5	1.1	0.4	0.2	0.2	1.1	-1.1
High blood pressure	1.5	4.3	10.1	-0.5	0.3	-1.8	3.2	-2.8
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.1	-1.0	1.1	0.6	-0.2	-1.0
Multivitamins +/- minerals	1.8	2.2	3.9	1.7	-1.0	1.5	-1.0	2.0
Stomach or abdominal pain in last month	1.1	1.4	3.3	0.8	1.8	0.5	0.5	-1.5
Supplements: Glucosamine	0.5	0.6	1.5	0.6	0.5	1.0	-0.3	1.2
Diverticular disease/diverticulitis (self-reported)	1.1	1.4	4.3	2.1	0.5	0.3	-0.9	-1.1
Medication: Atenolol	0.4	0.5	1.1	-0.6	0.1	-0.5	1.0	-1.0
Medication: Levothyroxine sodium	1.6	2.8	5.6	1.6	2.4	0.7	0.5	-2.2
Sitting height	0.2	1.4	4.7	-2.2	0.1	-0.3	-1.1	-1.1
Chronic bronchitis/emphysema (father)	0.4	0.4	1.0	1.0	-0.2	-0.9	0.1	-0.5
High blood pressure (mother)	3.3	4.7	9.1	0.3	-0.3	-2.3	3.0	-2.9
Body mass index (BMI)	0.4	1.9	5.7	-0.3	1.4	-1.0	2.4	0.9
Impedance of leg (left)	0.8	4.0	14.7	1.8	0.3	1.0	1.0	-3.8
Leg predicted mass (left)	0.2	1.2	2.3	-1.2	1.5	-0.7	0.9	1.1
Trunk fat mass	0.6	2.7	9.0	-0.6	1.8	-0.9	3.0	-0.1
Waist circumference	0.3	1.2	3.4	0.2	1.4	0.2	1.9	0.8
Number of incorrect matches in round	1.1	1.8	4.3	0.9	-2.1	-0.5	-1.5	-1.1
Past tobacco smoking	2.6	4.7	13.8	-2.2	-1.5	-1.4	-1.0	3.7
Alcohol usually taken with meals	0.8	1.3	3.1	1.3	0.6	0.0	1.8	-1.1
Nervous feelings	1.1	2.1	8.3	-1.2	-0.9	-0.2	-2.9	-0.2
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.3	5.3	2.2	1.2	2.2	-0.2	-2.3
Hearing difficulty/problems with background noise	0.7	1.2	4.8	-0.3	-0.5	0.8	-2.2	0.3
Hair/balding pattern: Pattern 2	0.6	0.7	1.1	1.0	0.5	0.6	-1.1	-0.9
Had menopause	0.3	0.3	0.6	-0.6	-0.8	0.3	-0.1	0.8
Had other major operations	0.1	0.1	0.2	-0.5	0.5	0.1	0.4	0.3
Forced vital capacity (FVC)	0.8	3.0	6.9	2.4	1.3	-0.7	0.5	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.6	0.4	0.0	0.4	-0.7	-1.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.1	0.7	1.0	1.0	1.0	-0.5
Qualifications: None of the above	0.3	0.5	1.5	0.1	1.2	-1.0	0.2	-0.4
Financial difficulties in last 2 years	0.8	1.1	2.7	1.4	1.6	0.7	-0.6	0.0
Mouth/teeth dental problems	1.5	2.4	7.1	-1.1	-0.9	-1.1	-1.2	2.7
Heart attack	1.1	1.4	2.6	-1.4	0.2	-1.6	1.6	-0.5
Allergy	0.7	1.7	3.7	0.7	-1.9	-0.9	-0.1	1.8
Pain all over the body in last month	0.2	0.2	0.7	0.0	0.8	-0.1	-0.6	-0.3
Diabetes (self-reported)	0.5	0.8	1.8	-0.2	-0.6	-0.5	1.2	-1.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.8	-0.5	-0.5	0.0	-0.9	0.3
Medication: Ramipril	1.8	2.3	7.3	0.2	1.1	-0.1	2.7	-1.7
Medication: Simvastatin	0.8	1.1	3.1	0.3	0.7	1.8	-0.3	-1.4
Fluid intelligence score	1.2	2.5	6.1	0.6	1.0	2.5	1.6	1.6
Illnesses of siblings	0.1	0.1	0.3	0.2	-0.5	-0.1	-0.4	0.5
Neuroticism score	0.7	1.5	6.8	0.1	-0.2	0.6	-2.6	0.2
Weight	0.4	2.1	5.3	-0.5	2.1	-0.9	2.3	0.2
Impedance of arm (right)	0.1	0.5	1.6	-0.4	-1.3	0.6	-0.4	0.3
Arm fat percentage (right)	0.5	2.1	6.8	-0.8	1.1	-0.7	2.6	1.2
Trunk fat-free mass	0.1	0.6	1.4	-0.8	1.2	-0.9	0.5	-0.0
Hip circumference	0.4	1.8	7.1	-0.6	1.3	-0.2	0.2	2.7
Time employed in main current job	0.2	0.2	0.5	-0.3	0.5	0.1	0.7	-0.5
Alcohol intake versus 10 years previously	0.3	0.4	0.8	-0.8	0.9	-0.6	0.2	0.2
Father’s age at death	0.9	1.2	3.0	1.7	1.3	0.5	-0.9	0.5
Worrier / anxious feelings	1.2	2.4	9.1	-0.8	-0.1	1.4	-3.0	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.0	1.2	1.4	-0.5	0.9	-0.7
Falls in the last year	0.7	1.0	3.9	-0.9	-0.4	-0.4	-2.0	0.3
Hair/balding pattern: Pattern 3	1.7	2.5	6.7	-1.1	-1.8	-2.6	0.1	1.1
Number of live births	0.2	0.2	1.0	1.0	0.1	0.0	0.5	-0.0
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	8.1	2.9	2.0	-0.7	0.9	-2.6
Pulse rate	2.9	5.0	13.3	-3.7	-2.2	-2.2	-0.3	1.4
Happiness	1.5	1.9	3.5	1.2	-0.1	1.3	-1.9	1.6
Noisy workplace	4.0	4.9	7.6	-1.9	-2.4	-2.8	-2.6	1.0
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	-0.2	-0.4	0.7	-0.0	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.7	-1.1	-0.6	0.5	-0.7	1.6
Mouth/teeth dental problems: Dentures	1.2	2.0	6.5	-1.1	-0.1	-1.0	1.1	-2.6
Asthma	0.5	1.0	1.8	-1.0	-0.0	1.2	-1.3	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.7	0.5	-0.7	-0.0	1.3	0.1
Medication: Cholesterol lowering	2.9	4.5	8.1	0.5	2.3	1.2	2.9	-2.7
Depression (self-reported)	1.5	1.8	4.2	0.5	1.5	1.0	1.1	-2.1
Medication: Lansoprazole	2.1	2.4	7.3	0.4	0.7	-0.3	2.0	-2.7
Prospective memory result	1.3	1.6	2.9	-0.7	-1.7	-1.0	-1.5	1.2
Lung cancer (father)	1.5	1.7	3.4	-1.3	-0.4	-0.8	1.9	-1.7
Illnesses of mother	1.8	2.3	5.9	0.8	2.4	1.6	-1.4	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	5.4	2.3	1.5	-1.0	0.4	-2.3
Pulse wave Arterial Stiffness index	1.4	1.7	3.1	-1.0	-1.8	-1.1	1.7	-0.4
Impedance of arm (left)	0.1	0.6	1.4	-0.4	-1.2	0.9	-0.4	0.6
Arm fat mass (right)	0.5	2.2	7.1	-0.7	1.6	-0.8	2.7	0.7
Trunk predicted mass	0.1	0.7	1.4	-0.9	1.2	-1.1	0.5	-0.2
Standing height	0.1	0.9	2.1	-0.8	1.2	-0.3	0.3	-1.5
Length of working week for main job	2.1	2.3	6.0	-1.9	-1.2	-2.5	0.6	-0.3
Exposure to tobacco smoke at home	0.7	0.8	2.0	-1.1	-0.8	-0.2	-1.4	0.2
Breastfed as a baby	0.3	0.4	0.9	0.1	-0.7	1.0	-0.5	0.2
Tense / ‘highly strung’	0.4	0.7	1.1	-0.6	-0.8	-0.8	-1.1	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.9	1.2	0.1	0.4	-0.4	-2.0
Hair/balding pattern: Pattern 4	0.3	0.7	1.6	-0.1	-0.9	0.9	-1.3	0.6
Birth weight of first child	0.1	0.2	0.4	-0.1	0.5	0.1	-0.5	0.6
Peak expiratory flow (PEF)	1.9	4.5	9.3	3.0	2.8	-0.5	1.5	-1.7
Pulse wave reflection index	0.3	0.4	1.4	0.0	-1.2	-0.5	-0.1	0.7
Ever highly irritable/argumentative for 2 days	0.5	0.5	1.2	0.9	0.1	-0.3	-0.8	1.1
Loud music exposure frequency	1.5	1.6	3.6	-0.8	-1.0	-1.9	1.7	-0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.7	0.7	0.8	0.8	0.3	-0.3
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	4.5	1.7	0.8	2.1	0.7	-0.9
Blood clot in the leg (DVT)	0.4	0.5	2.4	-0.3	1.6	-0.3	0.3	-0.2
Medication: Paracetamol	0.3	0.5	1.9	0.0	-0.0	0.4	1.4	-0.5
Headache pain in last month	0.8	1.4	3.3	0.8	0.8	0.6	1.8	-1.4
Medication for cholesterol, blood pressure or diabetes	2.6	4.3	11.8	0.6	-1.7	1.0	-3.4	2.3
Glaucoma (self-reported)	0.8	0.9	2.1	-0.0	0.6	-1.2	-1.5	0.8
Gout (self-reported)	0.9	1.2	2.5	-0.3	0.3	-1.6	1.4	-1.2
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	7.4	1.1	1.6	-0.3	0.1	-2.7
Medication: Amlodipine	1.4	1.9	4.2	1.0	0.8	0.8	1.7	-2.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.4	-0.2	-0.0	-0.0	-0.4
Birth weight	0.4	0.8	1.8	-0.5	-0.8	-1.4	-0.9	0.7
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.8	-1.3	-1.3	-0.9	-0.4	0.3
High blood pressure (siblings)	0.2	0.3	0.7	-0.8	0.2	0.5	-0.8	-0.2
Forced vital capacity (FVC), Best measure	0.7	2.4	5.2	2.2	1.4	-0.3	-0.2	-2.3
Body fat percentage	0.6	2.3	8.9	-0.3	1.5	-0.7	3.0	-0.1
Leg fat percentage (right)	0.8	2.8	7.5	0.9	2.1	-0.4	2.7	-1.2
Arm fat-free mass (right)	0.2	0.9	2.5	-0.6	1.6	-0.7	1.0	-0.3
Exposure to tobacco smoke outside home	0.9	1.2	3.0	-1.3	0.1	-1.0	-1.7	-0.2
Comparative body size at age 10	0.6	1.6	3.4	1.4	1.9	1.0	-1.0	0.9
Number of full brothers	2.2	2.7	5.2	2.1	2.3	1.7	1.1	0.1
Worry too long after embarrassment	1.4	2.3	5.3	1.3	1.0	1.8	-2.3	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.0	-0.4	-1.2	-0.5	-1.4	-1.3
Wheeze or whistling in the chest in last year	1.7	3.0	11.4	0.4	1.7	0.3	0.4	-3.4
Number of children fathered	0.9	1.0	2.8	0.9	0.6	-1.0	0.1	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.3	0.8	-0.3	0.7	-1.5	-0.9
Age at first live birth	0.4	0.6	2.1	0.0	-0.4	-0.5	-0.8	1.4
Pulse wave peak to peak time	1.5	1.7	4.2	1.1	2.1	1.0	-1.5	0.1
Health satisfaction	0.4	0.5	1.6	-0.3	-0.7	-0.4	-0.5	1.2
Shortness of breath walking on level ground	0.8	0.9	2.9	-0.6	-1.7	-1.2	-0.1	0.0
Qualifications: College or University degree	0.3	1.0	1.8	-0.9	-1.2	0.1	1.3	0.8
Eye problems/disorders: None of the above	0.4	0.4	0.9	0.4	-1.0	-0.6	0.7	-0.4
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.7	0.4	-1.3	-1.1	0.9	-0.4
Emphysema/chronic bronchitis	1.0	1.1	5.0	-0.8	0.2	-0.3	0.2	-2.2
Medication for pain relief, constipation, heartburn	1.2	2.1	7.2	-0.6	-0.8	-0.1	-2.7	1.5
Neck or shoulder pain in last month	1.8	2.5	6.0	2.5	1.8	0.7	1.5	-0.6
Medication: Blood pressure	2.3	4.0	11.0	0.0	1.2	-2.1	3.3	-1.8
Angina (self-reported)	1.3	1.8	3.7	0.0	0.4	-1.2	1.8	-1.9
Migraine (self-reported)	0.7	0.9	3.6	-0.8	0.1	-0.4	1.9	-0.5
Medication: Ibuprofen	0.4	0.5	1.4	0.3	-0.8	-0.5	1.2	0.3
Medication: Allopurinol	1.2	1.6	5.9	-0.8	-0.9	-2.4	0.7	-0.5
Medication: Omeprazole	2.1	2.5	5.4	-1.6	-0.0	-2.3	0.8	-2.1
Medication: Seretide 50 evohaler	0.7	0.9	2.6	-1.6	-1.0	-0.3	-0.1	-0.8
Mean time to correctly identify matches	1.6	3.0	5.3	-2.0	-2.1	0.8	-2.3	0.6
Heart disease (mother)	0.8	1.0	2.2	-1.3	-0.9	-1.5	-0.4	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.2	-0.1	-0.2	-1.4	1.5	0.8
Whole body fat mass	0.7	2.8	9.5	-0.4	1.8	-0.9	3.1	-0.2
Leg fat mass (right)	0.7	2.8	7.9	0.1	2.1	-0.9	2.8	-0.6
Arm predicted mass (right)	0.2	1.2	2.6	-0.5	1.6	-1.2	1.2	-0.5
Pulse rate, automated reading	1.6	5.0	8.9	-3.0	-2.8	-2.1	1.9	0.3
Alcohol intake frequency.	1.2	2.8	8.9	-1.6	-1.2	-3.0	-0.6	1.0
Comparative height size at age 10	0.6	3.4	7.2	-2.7	-0.6	-2.2	-0.6	-2.0
Number of full sisters	1.7	2.1	6.4	0.8	0.6	-0.8	2.5	-1.6
Suffer from ‘nerves’	1.0	1.5	4.5	-0.3	-0.7	-1.3	-2.1	-0.8
Overall health rating	0.7	1.5	3.2	0.6	0.8	-1.0	1.6	-1.8
Chest pain or discomfort	0.1	0.2	0.3	0.4	-0.0	0.5	-0.6	-0.4
Had major operations	3.0	3.5	7.1	1.3	2.4	0.8	2.7	-1.5
Age at last live birth	0.6	0.9	2.0	0.9	0.1	0.4	-1.4	1.3
Family relationship satisfaction	0.3	0.4	0.9	0.4	0.2	-1.0	0.5	-0.7
Leg pain on walking	0.7	0.9	3.0	0.2	-0.6	-1.7	0.7	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.9	0.0	-0.4	-0.9	-1.0	-0.4
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.1	0.1	0.8	0.1	-1.4	0.5
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.8	-0.8	-1.9	-0.6	-0.8	0.6
Medication: Aspirin	2.1	2.8	6.6	0.7	1.7	0.9	2.6	-1.8
Supplements: Vitamin C	1.2	1.4	4.2	0.1	-1.7	-0.1	-0.0	2.0
Knee pain experienced in last month	1.1	1.7	3.9	0.2	0.8	-1.3	1.5	-2.0
Hypertension (Self-reported)	1.9	5.2	11.4	-0.6	0.2	-2.1	3.4	-3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.2	-0.9	0.0	-1.4	0.1	-2.1
Illnesses of father: Heart disease	1.1	1.5	3.8	0.1	0.6	-1.1	2.0	-1.5
Illnesses of siblings: Diabetes	0.3	0.3	0.9	-0.1	1.0	-0.9	-0.2	0.1
Smoking status: Previous	2.0	3.0	7.4	2.3	1.0	1.1	0.3	-2.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.7	0.0	1.3	-1.0	0.5	-1.0
Whole body fat-free mass	0.2	0.9	2.1	-0.8	1.5	-0.8	0.9	0.2
Leg fat-free mass (right)	0.3	1.4	2.4	-1.2	1.6	-0.5	0.9	1.4
Arm fat percentage (left)	0.5	2.0	6.6	-0.8	1.1	-0.6	2.6	1.1
Average weekly red wine intake	2.3	3.4	8.9	1.8	0.9	1.3	1.6	-3.0
Handedness (chirality/laterality): Left-handed	1.6	1.9	3.8	-1.2	-2.0	-1.1	-1.6	0.8
Mood swings	0.7	1.2	2.5	1.6	1.3	1.1	-0.0	-0.8
Loneliness, isolation	0.1	0.1	0.6	0.1	0.8	0.2	0.1	-0.2
Long-standing illness, disability or infirmity	0.9	1.4	3.1	-0.1	1.6	0.3	1.8	-1.1
Ever had bowel cancer screening	0.2	0.3	0.9	0.4	0.6	0.0	-0.2	-0.9
Diabetes diagnosed by doctor	0.5	0.7	1.8	-0.3	-0.1	-0.8	1.1	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.7	-0.4	1.4	1.7	0.1	0.3
Friendships satisfaction	0.4	0.4	0.8	0.7	-0.9	-0.4	0.0	0.9
Qualifications: nursing, teaching	0.6	1.0	3.8	-0.3	-1.9	0.3	1.0	-0.0
Commuting to job workplace: Walk	0.9	1.0	4.7	-0.1	-0.4	2.2	-0.0	0.2
Eye problems/disorders: Cataract	0.9	1.0	2.9	-0.5	1.1	1.7	-0.8	0.3
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	4.3	0.4	1.2	2.1	-0.2	0.7
Medication for cholesterol	0.3	0.5	1.3	0.1	-0.2	0.6	-0.7	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	0.3	0.2	-0.4	-0.5	-0.6
Back pain experienced in last month	0.2	0.4	1.3	-0.0	0.1	-1.1	0.7	-0.1
Mineral and other dietary supplements	1.7	2.2	6.4	0.9	1.9	-0.1	0.7	-2.5
Breast cancer (self-reported)	0.4	0.5	0.8	-0.8	-0.3	-0.9	-0.6	0.8
Asthma (self-reported)	0.4	0.9	1.3	-0.9	0.1	1.1	-1.1	-1.0
Osteoporosis (self-reported)	0.9	1.2	2.7	0.0	1.0	-1.4	0.6	1.6
Osteoarthritis (self-reported)	0.8	1.0	2.7	-0.4	-0.7	-1.6	1.3	-0.0
Medication: Aspirin	1.4	1.8	5.0	0.4	1.3	0.1	2.2	-1.4
Medication: Gliclazide	2.4	2.7	7.1	1.3	0.8	-0.1	2.1	-2.7
Illnesses of father: None of the above (group 1)	0.5	0.7	1.6	0.3	0.4	1.3	-1.2	0.3
Smoking status: Current	1.5	2.4	7.8	-0.2	0.5	-0.1	2.0	-2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.7	0.1	0.2	-1.3	-1.1	0.5
Whole body water mass	0.2	0.9	2.1	-0.8	1.5	-0.8	1.0	0.2
Leg predicted mass (right)	0.3	1.4	2.3	-1.2	1.5	-0.5	1.0	1.4
Arm fat mass (left)	0.5	2.2	6.9	-0.8	1.4	-0.8	2.6	0.8
Number of self-reported non-cancer illnesses	3.0	5.3	11.7	0.8	3.4	-0.1	2.2	-3.0
Average weekly champagne plus white wine intake	0.3	0.5	1.6	1.3	-0.2	0.1	0.8	-0.2
Miserableness	2.0	3.5	9.1	3.0	1.3	1.9	-0.4	-1.8
Guilty feelings	1.3	1.9	4.5	1.4	0.5	0.7	-1.5	2.1
Wears glasses or contact lenses	0.7	0.8	1.5	0.7	1.2	0.7	1.2	0.5
Ever taken oral contraceptive pill	0.5	0.6	1.0	0.9	0.9	1.0	-0.4	-0.6
Hearing aid user	0.4	0.5	1.6	-0.2	-0.5	-1.3	-0.3	-0.6
Mother’s age at death	1.5	1.9	4.3	-0.4	-1.6	0.2	-1.5	2.1
Financial situation satisfaction	1.9	2.4	5.8	0.3	-1.1	-0.6	-2.4	2.1
Tinnitus: Yes, now most or all of the time	2.1	2.5	6.1	-0.9	-2.5	-0.8	-2.0	0.9
Commuting to job workplace: Public transport	0.5	0.6	1.7	-0.5	-0.2	1.0	0.3	1.3
Eye problems/disorders: Glaucoma	0.4	0.4	1.8	0.0	0.5	-1.4	-0.2	0.3
Medication: Blood pressure	0.5	0.9	1.9	-1.4	-0.4	-0.4	1.3	-0.8
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.1	0.4	0.7	-1.4	1.4	-0.5
Supplements: Fish oil (including cod liver oil)	1.9	2.4	5.0	-1.1	-2.2	-0.9	-0.6	2.2
High cholesterol (Self-reported)	0.9	1.6	6.5	-0.6	-0.2	-0.9	0.4	-2.5
Medication: Bendroflumethiazide	0.6	0.9	1.8	-1.1	0.0	-1.3	1.2	-0.1
Medication: Paracetamol	0.1	0.1	0.3	-0.6	-0.2	-0.2	0.5	-0.1
Medication: Lisinopril	1.3	1.6	3.6	-0.7	-0.6	-1.9	1.9	-0.5
Medication: Atorvastatin	4.2	5.2	18.0	0.5	0.5	-1.3	4.2	-2.3
Illnesses of father: High blood pressure	0.9	1.2	3.9	0.3	-0.0	-2.0	1.0	-0.9
Alcohol drinker status: Never	0.2	0.2	0.6	-0.8	-0.3	-0.5	0.3	-0.0
Ever smoked	2.8	4.9	14.0	2.6	1.2	1.1	0.9	-3.7
Basal metabolic rate	0.2	1.3	3.0	-0.8	1.7	-0.8	1.4	0.3
Leg fat percentage (left)	1.0	3.6	9.7	0.9	2.4	-0.3	3.1	-1.3
Arm fat-free mass (left)	0.3	1.4	2.9	-0.5	1.7	-1.0	1.6	-0.6
Number of operations (self-reported)	0.4	0.5	1.2	0.3	1.1	-0.6	0.3	-1.0
Average weekly beer plus cider intake	0.2	0.4	0.5	-0.7	-0.4	-0.6	-0.5	0.7
Irritability	0.8	1.4	4.1	-0.2	1.2	1.1	-2.0	0.4
Risk taking	0.2	0.3	0.8	-0.4	0.6	-0.1	0.9	-0.0
Ever had prostate specific antigen (PSA) test	2.8	3.2	7.1	2.5	2.7	1.0	1.1	-1.0
Fractured/broken bones in last 5 years	0.6	0.8	1.7	-0.1	0.0	-1.3	1.0	-1.1
Age started oral contraceptive pill	1.8	2.2	4.3	-1.4	-1.2	-0.2	-1.9	2.1
Diastolic blood pressure, automated reading	2.2	6.9	13.9	-3.4	-2.4	-3.7	1.9	0.4
Ever depressed for a whole week	0.4	0.5	1.2	1.1	0.4	0.3	0.7	-0.6
Unable to work because of sickness or disability	1.3	1.7	3.6	-0.3	1.9	1.0	1.4	-1.3
Commuting to job workplace: Cycle	0.9	1.1	2.8	-0.1	-1.7	1.5	-0.7	0.3
Myopia	2.1	3.0	8.2	-0.4	-2.1	-0.7	-1.4	2.9
Vascular/heart problems diagnosed by doctor	1.6	4.2	10.3	0.6	-0.6	1.8	-3.2	2.6
Cholesterol lowering medication	0.6	0.9	2.8	0.9	-0.9	-0.3	0.2	-1.7
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	4.4	-1.0	0.2	-2.1	0.7	-1.8
Pain experienced in last month	1.8	3.0	4.6	-1.7	-2.2	-0.5	-1.8	2.0
Supplements: Calcium	1.3	1.4	3.6	-1.9	-0.9	-0.4	-0.6	1.5
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	0.1	-0.2	-0.3	0.2	-0.5
Heart attack/myocardial infarction (self-reported)	1.2	1.5	4.2	-1.0	0.4	-1.4	2.0	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.3	-0.1	1.5	0.1	-0.3	0.2
Heart disease (siblings)	0.9	1.2	2.6	0.7	1.0	0.3	1.6	-1.2
Alcohol drinker status: Previous	0.5	0.5	1.5	-0.0	-0.9	-0.6	0.0	-1.2
Pack years of smoking	1.2	1.7	4.5	-0.5	0.2	-1.8	2.1	-0.5
Impedance of whole body	0.1	0.7	2.3	0.4	-0.8	0.7	0.2	-1.5
Leg fat mass (left)	0.9	3.4	10.0	0.2	2.3	-0.9	3.2	-0.8
Arm predicted mass (left)	0.3	1.3	2.8	-0.5	1.7	-1.1	1.4	-0.6