TWAS hub - HPD

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.128	0.0480	1.4e-03	-0.004	NA	0.003	NA	-0.003	6.2e-01	NA	2.1e-01	NA	5.1e-01
2	GTEx	Cells Transformed fibroblasts	0.105	0.0420	3.0e-03	0.023	NA	0.017	NA	0.007	7.6e-03	NA	1.9e-02	NA	9.0e-02
3	GTEx	Heart Atrial Appendage	0.689	0.0660	7.5e-09	-0.005	NA	0.074	NA	0.003	6.3e-01	NA	3.2e-04	NA	2.3e-01
4	GTEx	Heart Left Ventricle	0.114	0.0456	2.0e-03	0.138	NA	0.116	NA	0.121	8.9e-08	NA	9.8e-07	NA	5.5e-07
5	GTEx	Muscle Skeletal	0.117	0.0352	1.9e-06	0.093	NA	0.108	NA	0.120	2.2e-09	NA	9.6e-11	NA	8.7e-12
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.188	0.1030	5.4e-03	0.013	0.004	0.049	NA	0.067	5.5e-02	0.18	8.3e-04	NA	1.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5	6
Blood Platelet Count	5.3	61.2	231.0	15.2	3.3	4.9	5.2	8.6
Angina (self-reported)	3.8	5.0	12.3	3.5	-1.2	2.8	2.9	0.0
Angina	3.5	4.6	11.5	3.4	-1.1	2.7	2.8	0.0
Lupus	3.2	4.9	13.2	-2.1	0.3	-3.4	-3.6	-0.1
Triglycerides	3.1	5.1	9.7	-3.1	2.1	-3.0	-2.6	-0.8
Long-standing illness, disability or infirmity	3.1	4.7	11.8	3.4	1.4	2.5	2.9	0.0
Unable to work because of sickness or disability	3.1	4.0	8.7	2.5	-0.9	2.9	2.9	0.0
Heart attack/myocardial infarction (self-reported)	3.1	3.9	14.4	3.8	1.6	1.6	2.0	0.0
HDL Cholesterol	3.0	5.1	10.9	2.9	-1.1	3.3	2.8	1.4
Severe depression (siblings)	3.0	3.4	7.5	2.3	-0.3	2.7	2.7	0.0
Heart attack	3.0	3.9	14.7	3.8	1.1	1.7	2.2	0.0
Number of self-reported non-cancer illnesses	2.8	4.8	12.2	3.5	-0.0	2.7	3.1	0.0
Shortness of breath walking on level ground	2.7	3.2	8.2	1.9	0.2	2.9	2.7	0.0
Myopia	2.6	3.8	8.9	2.8	-0.5	2.4	3.0	0.0
Type 2 Diabetes (T2D) (2018)	2.4	4.5	10.0	3.2	1.3	2.1	2.5	2.3
Diabetes (self-reported)	2.1	3.2	10.4	3.2	1.1	1.7	2.1	0.0
Pulse wave peak to peak time	2.1	2.4	7.8	-2.8	0.1	-1.8	-1.9	0.0
Body fat percentage	2.0	7.9	16.2	3.4	4.0	3.1	3.2	0.0
Medication: Atorvastatin	2.0	2.5	6.1	2.5	-0.7	2.0	2.1	0.0
Mean Putamen Volume	1.9	2.2	11.1	0.8	1.1	-0.3	-0.1	3.3
Trunk fat percentage	1.9	7.8	14.4	3.4	3.8	3.2	3.2	0.0
Pulse wave Arterial Stiffness index	1.9	2.3	7.4	2.7	0.2	1.6	1.9	0.0
Mean time to correctly identify matches	1.9	3.7	9.2	2.3	-1.1	3.0	2.5	0.0
Whole body fat mass	1.9	7.9	16.0	3.4	4.0	2.9	3.4	0.0
Overall health rating	1.9	4.0	10.9	3.3	0.3	2.2	2.8	0.0
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	4.9	-2.2	-1.5	-2.0	-1.6	0.0
Diabetes diagnosed by doctor	1.9	3.1	10.0	3.2	0.8	1.7	2.2	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	4.7	2.2	1.5	1.6	1.9	0.0
Diverticular disease/diverticulitis (self-reported)	1.7	2.1	6.6	2.6	0.4	1.6	1.8	0.0
Trunk fat mass	1.7	7.4	16.6	3.3	4.1	2.7	3.1	0.0
Leg fat mass (right)	1.7	6.7	12.0	3.3	3.5	2.6	3.3	0.0
Arm fat percentage (left)	1.7	6.7	14.4	3.1	3.8	2.8	2.9	0.0
Eye problems/disorders: Cataract	1.7	1.9	3.9	1.9	-0.9	2.0	1.8	0.0
Leg fat mass (left)	1.7	6.8	14.4	3.2	3.8	2.4	3.2	0.0
Verbal and Numeric Reasoning (VNR)	1.6	3.9	9.0	0.4	-2.4	2.5	1.5	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	6.9	-2.4	2.2	-2.2	-2.6	0.0
Hip circumference	1.6	6.9	15.4	3.2	3.9	2.6	3.1	0.0
Leg fat percentage (right)	1.6	5.9	11.0	3.0	3.3	2.7	2.9	0.0
Medication: Metformin	1.5	2.2	7.0	2.6	1.7	0.8	1.5	0.0
Waist circumference	1.5	5.4	11.7	3.4	3.1	1.8	2.7	0.0
Financial difficulties in last 2 years	1.5	2.0	4.7	2.0	0.2	1.9	2.2	0.0
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	12.1	-0.5	-3.5	1.0	1.1	0.0
Health satisfaction	1.5	1.9	10.6	0.5	3.3	-0.7	-0.2	0.0
Migraine (self-reported)	1.5	1.8	4.1	-2.0	-0.2	-1.9	-1.7	0.0
Eye problems/disorders: Glaucoma	1.5	1.8	4.2	-1.7	-0.1	-1.9	-2.0	0.0
Leg fat percentage (left)	1.5	5.5	14.3	2.8	3.8	2.2	2.5	0.0
BMI	1.4	7.9	12.2	2.6	3.4	2.6	3.2	3.5
Medication: Levothyroxine sodium	1.4	2.3	5.0	2.2	1.5	1.6	2.0	0.0
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	4.8	2.1	1.7	2.2	2.2	0.0
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	4.6	-1.7	0.1	-1.7	-2.1	0.0
Osteoporosis (self-reported)	1.4	1.7	3.4	1.8	1.2	1.7	1.5	0.0
Medication: Aspirin	1.4	1.8	7.5	2.7	1.2	0.7	1.2	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	6.9	-2.6	-2.0	-1.6	-2.2	0.0
Arm fat mass (left)	1.4	5.9	14.6	2.8	3.8	2.2	2.8	0.0
Ever used hormone-replacement therapy (HRT)	1.3	1.6	4.4	2.1	0.1	1.4	1.8	0.0
Taking other prescription medications	1.3	1.9	5.2	2.1	2.3	0.6	1.3	0.0
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.8	6.0	-1.6	2.2	-2.0	-2.5	0.0
Arm fat percentage (right)	1.3	5.2	15.2	2.5	3.9	2.2	2.3	0.0
Falls in the last year	1.3	1.8	4.8	2.2	0.7	1.5	1.8	0.0
Mouth/teeth dental problems: Dentures	1.3	2.3	5.0	-1.0	2.0	-2.2	-1.8	0.0
Arm fat mass (right)	1.3	5.2	12.8	2.7	3.6	2.1	2.6	0.0
Comparative body size at age 10	1.3	3.6	9.4	3.1	0.7	2.3	2.6	0.0
Reaction Time	1.2	2.2	6.3	1.6	-1.3	2.5	1.7	-0.3
Body Mass Index (BMI) (2010)	1.2	1.6	6.7	1.2	2.6	0.6	1.0	0.0
Respiratory disease	1.2	2.6	14.0	1.0	-0.0	0.4	0.8	3.7
Supplements: Glucosamine	1.2	1.5	4.7	-2.2	-0.7	-1.2	-1.6	0.0
Qualifications: None of the above	1.2	2.6	14.3	0.7	3.8	-0.6	-0.4	0.0
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	3.5	1.5	0.1	1.5	1.9	0.0
Loneliness, isolation	1.2	1.6	4.7	2.1	2.2	0.3	0.7	0.0
Pack years of smoking	1.2	1.8	5.1	2.3	1.4	1.1	1.5	0.0
Heel T-Score	1.1	8.8	18.8	-2.9	0.5	-3.5	-4.3	-3.7
Number of treatments/medications taken	1.1	1.9	6.8	2.6	1.1	1.0	1.6	0.0
Frequency of depressed mood in last 2 weeks	1.1	1.5	8.6	0.6	2.9	0.3	-0.2	0.0
Pack years adult smoking proportion	1.1	1.7	4.9	2.2	1.4	1.1	1.4	0.0
Body mass index (BMI)	1.1	4.9	12.8	2.7	3.6	1.8	2.5	0.0
Weight	1.1	5.3	13.1	2.9	3.6	1.7	2.8	0.0
Breastfed as a baby	1.1	1.3	6.7	-1.1	-2.6	-0.1	-0.0	0.0
Neck or shoulder pain in last month	1.1	1.6	4.1	-2.0	-1.6	-1.3	-1.2	0.0
Commuting to job workplace: Car/motor vehicle	1.1	1.3	4.3	0.8	-2.1	1.0	1.3	0.0
Medication: Aspirin	1.1	1.5	6.5	2.6	0.9	0.6	1.1	0.0
Guilty feelings	1.1	1.7	5.2	2.2	2.3	-0.2	0.1	0.0
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.7	1.5	-0.2	1.6	1.6	0.0
Supplements: Fish oil (including cod liver oil)	1.1	1.5	3.2	-1.8	-0.3	-1.7	-1.6	0.0
Hearing difficulty/problems: Yes	1.0	1.5	4.9	1.6	2.2	0.6	1.0	0.0
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.3	1.1	0.9	1.8	1.6	0.0
Alcohol usually taken with meals	1.0	1.7	3.9	-2.0	-1.9	-1.3	-0.8	0.0
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.1	0.5	-1.8	1.2	1.5	0.0
Medication: Blood pressure	1.0	1.8	6.8	2.6	0.9	1.3	1.3	0.0
Mineral and other dietary supplements	1.0	1.3	3.2	1.8	1.0	1.5	1.2	0.0
Medication: Bendroflumethiazide	1.0	1.5	4.0	2.0	0.5	1.9	0.9	0.0
Vascular/heart problems diagnosed by doctor	1.0	2.8	11.0	-3.3	-0.1	-1.6	-1.9	0.0
Basal cell carcinoma (self-reported)	1.0	1.1	3.4	1.8	1.8	0.4	0.3	0.0
Bipolar Disorder or Schizophrenia	0.9	2.2	4.2	2.0	1.5	1.6	2.1	0.0
Smoking Status	0.9	2.2	7.8	0.6	2.2	-0.2	0.6	2.8
Hypothyroidism (self reported)	0.9	2.2	3.8	1.6	1.6	2.0	1.9	0.6
Townsend deprivation index at recruitment	0.9	1.3	6.4	1.1	2.5	-0.0	0.1	0.0
Allergy	0.9	2.0	5.2	1.0	-2.3	1.9	1.5	0.0
Tense / ‘highly strung’	0.9	1.5	3.3	-1.8	0.3	-1.8	-1.5	0.0
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	6.1	-2.5	-0.3	-1.1	-1.3	0.0
Schizophrenia (2018)	0.8	1.6	3.8	1.9	1.6	1.1	1.4	0.0
Rheumatoid Arthritis	0.8	1.1	2.3	1.4	0.5	1.5	1.4	0.0
Ever had hysterectomy (womb removed)	0.8	0.9	2.4	-1.1	1.6	-0.9	-0.8	0.0
Medication for hormone replacement therapy	0.8	0.9	2.2	1.5	0.9	1.1	1.1	0.0
Age when periods started (menarche)	0.8	1.9	5.3	-2.3	-1.5	-0.7	-1.8	0.0
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.9	1.2	1.7	0.8	1.0	0.0
Medication: Cholesterol lowering	0.8	1.2	3.9	2.0	0.9	1.0	1.2	0.0
Birth weight	0.8	1.7	7.6	0.1	-2.8	0.7	1.4	0.0
Age at last live birth	0.8	1.2	6.2	0.6	2.5	0.4	0.6	0.0
Hypertension (Self-reported)	0.8	2.2	7.6	2.8	0.2	1.6	1.6	0.0
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.3	1.5	1.8	0.7	0.3	0.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	6.6	-0.4	-2.6	1.0	0.5	0.0
Osteoarthritis (self-reported)	0.8	1.1	3.2	1.8	0.1	1.4	1.1	0.0
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.4	1.3	-0.2	1.5	1.4	0.0
Intelligence (Savage-Jansen 2018)	0.7	2.1	5.6	0.3	-2.1	2.4	1.4	0.0
Primary Biliary Cirrhosis	0.7	0.9	2.2	-1.0	1.1	-1.1	-1.5	-0.1
Systolic Blood Pressure	0.7	3.7	9.2	-1.5	-1.2	-3.0	-2.4	-1.9
Lung FVC	0.7	3.7	10.4	-3.2	-1.0	-2.0	-2.5	-0.9
Sensitivity / hurt feelings	0.7	1.1	3.5	1.9	0.4	1.2	1.3	0.0
Fed-up feelings	0.7	1.2	4.8	1.4	2.2	0.2	0.4	0.0
Birth weight of first child	0.7	1.2	5.3	-1.0	-2.3	0.6	0.9	0.0
Loud music exposure frequency	0.7	0.8	3.8	0.5	1.9	-0.7	-0.5	0.0
Qualifications: nursing, teaching	0.7	1.0	3.2	0.2	-1.8	1.4	1.1	0.0
Depressed Affect (Nagel 2018)	0.6	1.2	3.4	1.8	1.4	0.8	1.2	0.0
Depression (Nagel 2018)	0.6	0.9	4.5	1.1	2.1	0.3	0.1	0.0
Crohns Disease (2012)	0.6	0.9	1.9	1.2	-0.3	1.2	0.6	-1.4
Neuroticism (2016)	0.6	0.9	2.3	1.5	1.1	0.3	0.3	1.2
Blood Eosinophil Count	0.6	4.5	8.4	2.9	-2.0	2.8	2.5	0.7
Height	0.6	10.9	42.0	2.2	2.3	1.6	3.2	6.5
Relative age of first facial hair	0.6	1.3	3.6	1.5	-0.3	1.9	1.4	0.0
High blood pressure	0.6	1.5	5.9	2.4	-0.0	1.2	1.4	0.0
Hayfever, allergic rhinitis or eczema	0.6	1.3	5.7	-0.5	2.4	-1.0	-0.8	0.0
Stomach or abdominal pain in last month	0.6	0.7	1.4	0.9	-1.0	1.1	1.2	0.0
Had menopause	0.6	0.7	2.3	0.2	-1.1	0.9	1.5	0.0
Medication: Simvastatin	0.6	0.9	2.5	1.6	0.6	0.9	1.3	0.0
Alcohol intake versus 10 years previously	0.6	0.9	2.0	-1.4	0.5	-1.1	-1.3	0.0
Exposure to tobacco smoke at home	0.6	0.7	2.5	0.2	1.6	-0.8	-0.9	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.5	1.0	-0.3	1.6	1.4	0.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.2	1.5	1.3	0.2	0.7	0.0
Exposure to tobacco smoke outside home	0.6	0.8	1.8	1.3	-0.1	1.2	1.3	0.0
Eye problems/disorders: None of the above	0.6	0.6	3.4	-0.3	1.8	-0.5	-0.4	0.0
Pulse rate, automated reading	0.6	1.9	6.4	2.5	-0.0	1.1	1.9	0.0
Number of full sisters	0.6	0.7	2.9	-0.3	-1.7	0.9	0.6	0.0
Leg pain on walking	0.6	0.7	3.3	-0.1	1.8	-0.7	-0.8	0.0
Knee pain experienced in last month	0.6	1.0	2.1	1.2	0.8	1.4	1.3	0.0
Hearing aid user	0.6	0.7	2.1	0.6	1.1	0.8	1.5	0.0
Irritability	0.6	1.0	2.5	-1.1	0.5	-1.4	-1.6	0.0
Bipolar Disorder (2018)	0.5	0.7	2.2	0.7	0.4	1.2	1.5	0.0
Ulcerative Colitis (UC)	0.5	0.9	4.2	0.5	2.0	0.1	0.5	0.6
Age at First Birth	0.5	0.7	1.9	0.7	0.3	1.4	1.1	-0.7
Coronary Artery Disease (CAD)	0.5	0.6	2.5	1.6	0.5	0.8	0.5	0.0
Schizophrenia (2014)	0.5	1.0	2.2	1.5	1.1	0.9	1.5	0.0
Blood Red Count	0.5	5.1	9.1	-1.9	-1.7	-2.9	-2.6	3.0
Neuroticism	0.5	1.1	3.2	1.5	1.8	0.1	0.6	0.9
Leg fat-free mass (left)	0.5	2.7	7.0	2.0	2.7	0.9	2.1	0.0
Hand grip strength (right)	0.5	1.3	3.7	-1.5	0.1	-1.9	-1.4	0.0
Multivitamins +/- minerals	0.5	0.6	1.7	0.8	0.9	0.7	1.3	0.0
Leg predicted mass (left)	0.5	2.6	7.2	1.9	2.7	0.8	2.0	0.0
Medication: Ramipril	0.5	0.6	1.8	1.4	0.7	0.7	0.9	0.0
Fluid intelligence score	0.5	1.1	4.5	-0.7	-2.1	1.3	0.5	0.0
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.8	-0.9	-1.7	1.4	0.8	0.0
Lung cancer (father)	0.5	0.6	3.1	-0.0	1.8	-0.4	-0.2	0.0
Number of full brothers	0.5	0.6	1.4	-1.2	-1.1	-0.6	-0.9	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.4	-0.0	1.2	-1.2	-0.6	0.0
Had major operations	0.5	0.6	1.7	0.7	0.2	1.3	1.1	0.0
Illnesses of father: Heart disease	0.5	0.6	3.3	-0.7	-1.8	-0.3	-0.0	0.0
Mood swings	0.5	0.8	2.8	1.7	0.3	0.9	1.1	0.0
Commuting to job workplace: Walk	0.5	0.6	1.7	0.7	1.3	0.8	0.8	0.0
Crohns Disease (2017)	0.4	0.9	2.8	0.5	-0.6	1.2	0.7	-1.7
HbA1C	0.4	0.5	1.3	1.0	-0.4	0.7	1.1	-0.0
Allergy or Eczema	0.4	1.1	5.6	0.8	2.4	0.3	0.4	-0.0
Lung FEV1/FVC ratio	0.4	2.0	5.3	-1.2	-0.9	-1.2	-1.7	-2.3
Hand grip strength (left)	0.4	1.1	3.6	-1.1	0.3	-1.9	-1.3	0.0
Medication: Co-codamol	0.4	0.5	1.7	0.6	0.0	0.9	1.3	0.0
Current tobacco smoking	0.4	0.7	2.3	0.9	1.5	0.7	0.7	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.2	0.8	1.5	-0.1	0.3	0.0
Qualifications: CSEs or equivalent	0.4	0.6	1.7	-0.4	0.7	-1.3	-1.1	0.0
Hearing difficulty/problems with background noise	0.4	0.6	3.1	0.7	1.8	-0.2	-0.1	0.0
Had other major operations	0.4	0.5	1.4	0.2	-0.9	0.9	1.2	0.0
Mouth/teeth dental problems	0.4	0.6	2.2	0.8	1.5	0.3	-0.6	0.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.2	-0.4	0.7	-1.1	-1.1	0.0
Illnesses of siblings	0.4	0.6	1.5	-1.2	-0.4	-0.9	-1.0	0.0
Hair/balding pattern: Pattern 3	0.4	0.5	1.4	-0.2	0.7	-1.2	-1.1	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.4	0.9	-0.7	-0.7	-0.9	-0.9	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.5	-2.1	-0.5	-1.2	-1.3	0.0
Length of working week for main job	0.4	0.5	0.9	0.7	-0.7	0.9	1.0	0.0
Headache pain in last month	0.4	0.7	3.8	-0.1	-2.0	-0.1	0.7	0.0
Medication: Amlodipine	0.4	0.6	1.7	-0.9	-1.3	-0.7	-0.7	0.0
Number of children fathered	0.4	0.5	1.4	0.3	-1.2	0.5	1.1	0.0
Qualifications: College or University degree	0.4	1.2	3.2	0.3	-1.5	1.8	1.4	0.0
Leg fat-free mass (right)	0.4	2.1	7.7	1.5	2.8	0.3	1.6	0.0
Average weekly red wine intake	0.4	0.6	1.8	-1.4	0.1	-1.1	-0.6	0.0
Leg predicted mass (right)	0.4	2.0	6.9	1.6	2.6	0.4	1.6	0.0
Ever taken oral contraceptive pill	0.4	0.5	1.3	-0.4	0.3	-1.1	-1.2	0.0
Illnesses of father: High blood pressure	0.4	0.5	1.5	-0.2	-1.2	0.9	0.5	0.0
Risk taking	0.4	0.6	3.2	1.8	-0.0	0.2	0.5	0.0
Age started oral contraceptive pill	0.4	0.5	2.5	-0.3	-1.6	-0.2	0.4	0.0
Supplements: Calcium	0.4	0.4	0.7	-0.8	0.8	-0.8	-0.7	0.0
Major Depression (MDD)	0.3	0.3	1.4	0.6	1.2	-0.4	-0.3	0.0
Fasting Glucose	0.3	0.3	0.8	0.5	0.3	0.9	0.5	-0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.8	0.5	0.5	0.8	0.9	0.0
Blood White Count	0.3	1.9	4.8	2.2	1.1	0.2	1.0	2.1
Tanning	0.3	4.3	8.5	2.5	-0.4	2.6	2.9	1.9
Systolic blood pressure, automated reading	0.3	1.0	4.3	-0.2	0.2	-2.1	-1.2	0.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.1	0.9	-1.0	-0.1	0.3	0.0
Chronic bronchitis/emphysema (father)	0.3	0.4	1.1	-0.1	0.7	0.9	1.1	0.0
Number of live births	0.3	0.4	1.5	0.5	-0.5	0.6	1.2	0.0
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	3.1	-1.8	-0.2	-1.0	-1.2	0.0
Impedance of arm (left)	0.3	1.5	6.1	0.8	-1.1	2.5	1.1	0.0
Hair/balding pattern: Pattern 4	0.3	0.7	2.8	-0.8	-1.7	-0.9	-0.4	0.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.9	0.2	-0.4	0.6	1.4	0.0
Glaucoma (self-reported)	0.3	0.4	0.9	-0.6	-0.9	-0.6	-0.8	0.0
High blood pressure (siblings)	0.3	0.4	0.7	0.7	0.8	0.8	0.6	0.0
Wheeze or whistling in the chest in last year	0.3	0.6	1.9	1.4	0.3	0.8	0.9	0.0
Medication: Allopurinol	0.3	0.4	0.9	1.0	0.8	0.7	0.2	0.0
Medication: Seretide 50 evohaler	0.3	0.3	1.2	0.7	1.1	0.3	0.3	0.0
Heart disease (mother)	0.3	0.4	1.0	-0.7	0.2	-1.0	-1.0	0.0
Friendships satisfaction	0.3	0.4	1.7	-0.5	1.3	-0.6	-0.1	0.0
Smoking status: Current	0.3	0.4	1.6	0.7	1.3	0.3	0.3	0.0
Commuting to job workplace: Public transport	0.3	0.4	1.1	0.8	1.0	0.7	0.2	0.0
Medication: Lisinopril	0.3	0.3	1.7	1.3	0.6	-0.2	-0.2	0.0
Ever smoked	0.3	0.5	2.3	0.7	1.5	0.3	0.4	0.0
Basal metabolic rate	0.3	1.7	6.3	1.4	2.5	0.0	1.4	0.0
Arm fat-free mass (left)	0.3	1.3	6.1	0.9	2.5	-0.7	0.8	0.0
Number of operations (self-reported)	0.3	0.4	1.1	0.6	-0.8	0.7	1.1	0.0
Commuting to job workplace: Cycle	0.3	0.4	0.9	0.6	-0.4	0.8	1.0	0.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.1	-0.5	-0.3	-1.1	-0.8	0.0
Alcohol drinker status: Previous	0.3	0.3	1.5	-1.2	-0.4	-0.2	0.5	0.0
Neuroticism (Nagel 2018)	0.2	0.4	1.5	0.9	1.2	-0.1	0.4	0.0
Alzheimer’s Disease (in father)	0.2	0.2	0.8	0.0	-0.9	0.6	0.1	-0.4
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	0.6	1.1	0.7	0.7	-0.6
Bipolar Disorder (2011)	0.2	0.2	0.5	0.7	0.3	0.2	0.7	0.0
Waist Hip Ratio (WHR)	0.2	1.0	3.8	0.3	-2.0	-0.7	-0.3	1.3
Chronotype (morning person)	0.2	0.5	1.7	-0.7	0.0	-0.9	-0.4	-1.3
Vitamin and mineral supplements	0.2	0.3	1.2	-0.1	0.2	-0.8	-1.1	0.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.8	0.5	0.9	-0.3	-0.7	0.0
Medication: Atenolol	0.2	0.2	0.5	0.4	-0.7	0.3	0.6	0.0
High blood pressure (mother)	0.2	0.3	1.0	0.1	-0.6	1.0	0.5	0.0
Past tobacco smoking	0.2	0.4	1.9	-0.3	-1.4	0.5	-0.0	0.0
Hair/balding pattern: Pattern 2	0.2	0.2	0.9	-0.2	1.0	-0.1	-0.6	0.0
Forced vital capacity (FVC)	0.2	0.9	2.8	-1.7	0.7	-1.1	-1.0	0.0
Neuroticism score	0.2	0.4	1.7	1.3	0.9	-0.1	0.5	0.0
Impedance of arm (right)	0.2	0.9	4.2	0.5	-1.0	2.1	0.5	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	0.6	-0.4	0.5	0.9	0.0
Pulse rate	0.2	0.4	1.5	0.7	1.2	-0.1	0.3	0.0
Prospective memory result	0.2	0.3	0.8	0.6	0.7	0.3	0.9	0.0
Illnesses of mother	0.2	0.2	0.4	-0.6	0.6	-0.6	-0.6	0.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	-0.8	-0.5	-0.6	-0.2	0.0
Forced vital capacity (FVC), Best measure	0.2	0.8	3.2	-1.8	-0.6	-0.8	-0.8	0.0
Arm fat-free mass (right)	0.2	1.1	4.3	1.0	2.1	-0.5	1.1	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.8	0.6	0.5	0.4	0.0
Arm predicted mass (right)	0.2	1.2	3.6	1.3	1.9	-0.1	1.4	0.0
Suffer from ‘nerves’	0.2	0.3	1.4	-0.1	0.4	-1.2	-0.6	0.0
Family relationship satisfaction	0.2	0.3	0.6	0.6	0.5	0.7	0.6	0.0
Whole body fat-free mass	0.2	1.1	4.7	0.9	2.2	-0.5	1.0	0.0
Asthma (self-reported)	0.2	0.3	1.4	0.7	1.2	-0.2	0.2	0.0
Medication: Gliclazide	0.2	0.3	1.1	1.0	0.6	0.1	0.3	0.0
Whole body water mass	0.2	1.1	4.6	0.9	2.1	-0.5	1.0	0.0
Average weekly champagne plus white wine intake	0.2	0.3	1.3	-1.1	-0.3	-0.4	-0.4	0.0
Financial situation satisfaction	0.2	0.2	1.3	-0.1	1.1	-0.4	0.1	0.0
High cholesterol (Self-reported)	0.2	0.3	1.4	0.7	-1.2	0.3	0.4	0.0
Fractured/broken bones in last 5 years	0.2	0.3	0.7	0.2	-0.8	0.6	0.8	0.0
Diastolic blood pressure, automated reading	0.2	0.5	1.5	1.2	-1.1	0.0	0.5	0.0
Ever depressed for a whole week	0.2	0.3	0.8	0.3	0.9	0.5	0.8	0.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	0.2	-0.7	0.8	0.4	0.0
Pain experienced in last month	0.2	0.4	1.1	1.1	0.3	0.8	0.6	0.0
Arm predicted mass (left)	0.2	1.0	4.4	0.7	2.1	-0.7	0.7	0.0
Schizophrenia vs Biploar Disorder	0.1	0.1	0.4	0.1	-0.1	-0.6	-0.6	0.0
Alzheimer’s Disease (in mother)	0.1	0.1	0.5	0.1	-0.1	0.7	0.5	-0.2
Alzheimer’s Disease (including proxy)	0.1	0.2	0.7	-0.3	-0.4	0.3	0.2	0.8
Ovarian Cancer	0.1	0.1	0.4	-0.2	-0.1	0.3	-0.1	0.6
LDL Cholesterol	0.1	0.1	0.4	0.0	-0.6	0.2	0.4	-0.5
Ulcerative Colitis	0.1	0.2	0.4	0.6	0.6	0.1	0.5	0.0
Cardiovascular Disease	0.1	0.4	1.2	1.1	-0.1	0.5	0.7	-0.6
Hair Pigment	0.1	1.8	4.2	1.4	2.0	0.5	0.7	2.0
Average weekly spirits intake	0.1	0.1	0.6	-0.3	0.8	0.2	0.0	0.0
Supplements: Zinc	0.1	0.2	0.6	0.6	0.7	0.3	-0.0	0.0
Diabetes (father)	0.1	0.1	0.2	-0.4	-0.2	0.2	0.4	0.0
Diabetes (mother)	0.1	0.1	0.4	-0.6	0.1	-0.5	-0.2	0.0
Impedance of leg (right)	0.1	0.7	3.2	-0.1	-1.8	1.0	-0.1	0.0
Average weekly fortified wine intake	0.1	0.1	0.6	-0.3	0.8	0.1	0.1	0.0
Relative age voice broke	0.1	0.1	0.4	0.3	0.4	0.6	-0.2	0.0
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.5	-0.1	0.3	0.5	0.0
Serious illness, injury or assault to yourself	0.1	0.2	0.4	-0.7	0.4	0.4	0.3	0.0
Sitting height	0.1	0.4	1.9	0.1	0.6	0.3	1.4	0.0
Impedance of leg (left)	0.1	0.3	0.9	-0.7	-1.0	0.4	-0.7	0.0
Number of incorrect matches in round	0.1	0.2	0.7	0.2	0.8	-0.1	0.6	0.0
Pain all over the body in last month	0.1	0.1	0.1	0.1	-0.4	0.3	0.4	0.0
Trunk fat-free mass	0.1	0.6	1.9	0.4	1.4	-1.1	0.5	0.0
Time employed in main current job	0.1	0.1	0.2	-0.3	0.4	-0.3	-0.1	0.0
Father’s age at death	0.1	0.2	0.5	-0.1	-0.5	-0.7	-0.5	0.0
Worrier / anxious feelings	0.1	0.1	0.3	0.2	-0.5	-0.5	-0.0	0.0
Happiness	0.1	0.1	0.6	0.3	-0.2	0.0	0.8	0.0
Noisy workplace	0.1	0.1	0.8	0.9	0.1	0.1	0.3	0.0
Asthma	0.1	0.3	1.2	0.5	1.1	-0.4	-0.0	0.0
Trunk predicted mass	0.1	0.6	2.0	0.5	1.4	-1.0	0.6	0.0
Pulse wave reflection index	0.1	0.2	0.5	0.5	0.7	0.5	0.3	0.0
Blood clot in the leg (DVT)	0.1	0.2	0.5	-0.2	-0.5	-0.7	-0.4	0.0
Medication: Paracetamol	0.1	0.2	0.7	0.1	-0.1	0.5	0.9	0.0
Gout (self-reported)	0.1	0.2	0.5	0.5	-0.3	0.7	0.5	0.0
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.5	0.6	0.7	-0.4	-0.2	0.0
Worry too long after embarrassment	0.1	0.2	0.6	-0.4	-0.2	-0.7	-0.6	0.0
Age at first live birth	0.1	0.2	0.9	0.4	0.9	0.4	0.5	0.0
Emphysema/chronic bronchitis	0.1	0.1	0.5	0.4	0.2	0.1	0.7	0.0
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	-0.6	0.2	-0.1	-0.4	0.0
Medication: Ibuprofen	0.1	0.1	0.5	-0.2	-0.7	-0.2	-0.1	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.6	0.2	-0.8	-0.1	0.1	0.0
Comparative height size at age 10	0.1	0.6	2.2	0.7	0.6	0.7	1.5	0.0
Chest pain or discomfort	0.1	0.1	0.4	0.6	0.1	-0.3	0.1	0.0
Supplements: Vitamin C	0.1	0.2	0.4	-0.6	-0.6	0.4	0.3	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.4	-0.5	-0.1	-0.6	-0.6	0.0
Smoking status: Previous	0.1	0.2	1.0	0.4	1.0	-0.1	0.2	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.9	0.5	1.0	-0.3	-0.0	0.0
Ever had bowel cancer screening	0.1	0.2	0.4	0.5	-0.6	0.6	0.4	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.5	-0.2	-0.3	-0.7	-0.1	0.0
Medication for cholesterol	0.1	0.2	0.8	-0.9	-0.7	-0.1	-0.4	0.0
Back pain experienced in last month	0.1	0.1	0.2	-0.1	0.4	0.4	0.5	0.0
Breast cancer (self-reported)	0.1	0.2	0.5	-0.2	-0.7	0.2	0.7	0.0
Illnesses of father: None of the above (group 1)	0.1	0.1	0.6	0.8	0.2	0.1	0.3	0.0
Wears glasses or contact lenses	0.1	0.1	0.5	-0.7	-0.3	-0.4	0.1	0.0
Mother’s age at death	0.1	0.1	0.4	-0.6	-0.1	-0.6	-0.2	0.0
Medication: Blood pressure	0.1	0.3	1.1	1.0	0.4	0.4	0.3	0.0
Medication: Paracetamol	0.1	0.1	0.3	0.1	0.5	0.2	0.5	0.0
Alcohol drinker status: Never	0.1	0.1	0.4	-0.0	0.3	0.6	0.3	0.0
Average weekly beer plus cider intake	0.1	0.2	0.6	0.4	0.7	0.3	0.7	0.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	-0.3	0.6	-0.1	0.2	0.0
Cholesterol lowering medication	0.1	0.2	0.9	0.9	-0.2	-0.0	0.2	0.0
Heart disease (siblings)	0.1	0.1	0.5	0.3	-0.7	-0.1	-0.3	0.0
Impedance of whole body	0.1	0.8	3.1	0.3	-1.1	1.8	0.3	0.0
Worry (Nagel 2018)	0.0	0.0	0.1	-0.0	0.3	-0.4	0.3	0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Maternal smoking around birth	0.0	0.1	0.2	0.2	-0.2	0.2	0.5	0.0
Nervous feelings	0.0	0.1	0.2	0.2	-0.1	-0.4	0.3	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	0.2	-0.2	-0.1	0.2	0.0
Depression (self-reported)	0.0	0.1	0.2	0.3	-0.4	0.2	0.1	0.0
Medication: Lansoprazole	0.0	0.0	0.1	-0.0	-0.3	0.1	0.4	0.0
Standing height	0.0	0.2	0.8	0.6	0.4	-0.1	0.9	0.0
Peak expiratory flow (PEF)	0.0	0.1	0.3	-0.2	-0.4	0.5	0.0	0.0
Medication: Omeprazole	0.0	0.1	0.3	-0.2	-0.5	0.1	-0.1	0.0
Alcohol intake frequency.	0.0	0.0	0.1	-0.2	-0.0	0.2	0.2	0.0
Illnesses of siblings: Diabetes	0.0	0.0	0.1	0.1	0.2	-0.2	0.3	0.0
Miserableness	0.0	0.1	0.2	0.5	-0.4	-0.2	-0.1	0.0

Hub : Genes

HPD

Models

Trait associations