Hub : Genes

HPS3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.1128	0.0414	1.4e-10	0.073	0.048	0.063	NA	0.072	1.1e-14	4.2e-10	7.5e-13	NA	1.7e-14
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1110	0.0480	2.4e-03	-0.004	0.023	0.003	NA	0.000	6.0e-01	1.7e-02	2.0e-01	NA	3.3e-01
3	TCGA	Lung Adenocarcinoma	0.0532	0.0233	8.7e-04	0.017	0.016	0.019	NA	0.016	3.7e-03	4.3e-03	2.4e-03	NA	4.4e-03
4	TCGA	Lung Squamous Cell Carcinoma	0.0666	0.0371	7.2e-03	0.010	0.013	0.023	NA	0.017	2.1e-02	1.1e-02	1.1e-03	NA	4.2e-03
5	TCGA	Pheochromocytoma and Paraganglioma	0.1570	0.0680	1.7e-03	0.136	0.041	0.057	NA	0.114	4.7e-06	9.6e-03	2.8e-03	NA	2.8e-05
6	TCGA	Prostate Adenocarcinoma	0.1485	0.0615	3.2e-04	0.056	0.034	0.033	NA	0.049	1.7e-06	1.5e-04	1.8e-04	NA	7.5e-06
7	TCGA	Skin Cutaneous Melanoma	0.2160	0.0830	5.6e-04	0.105	0.138	0.060	NA	0.112	9.5e-04	1.6e-04	1.1e-02	NA	6.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.5	0.8	1.6	0.4	1.1	1.2	1.3	-0.1	0.9	0.1
Bipolar Disorder or Schizophrenia	0.9	2.1	5.8	1.0	1.3	2.4	1.8	-0.0	1.6	0.5
Depressed Affect (Nagel 2018)	0.1	0.3	1.0	-0.6	0.2	-0.0	-0.1	-0.7	-0.3	-1.0
Depression (Nagel 2018)	0.3	0.5	0.8	-0.3	0.9	0.4	0.6	0.9	-0.5	0.9
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.7	0.6	1.0	-0.1	0.3	0.2	1.0	1.3
Neuroticism (Nagel 2018)	0.2	0.4	1.6	-0.9	-0.5	-0.1	-0.3	-0.4	-0.5	-1.3
Schizophrenia (2018)	0.7	1.4	4.6	1.0	0.9	2.1	1.3	0.1	1.3	0.6
Schizophrenia vs Biploar Disorder	0.6	0.8	4.2	-0.2	-0.8	-0.2	-0.3	2.0	-0.4	0.4
Worry (Nagel 2018)	0.2	0.4	1.0	-1.0	0.5	0.5	-0.3	0.7	-0.8	-0.1
Alzheimer’s Disease (in mother)	0.6	0.7	3.8	-0.4	-0.3	0.3	0.7	2.0	-0.7	0.0
Alzheimer’s Disease (in father)	3.2	3.4	12.8	-1.4	-0.8	-3.6	-2.2	0.1	-1.6	-0.9
Alzheimer’s Disease (including proxy)	0.5	0.7	1.8	-0.8	-0.3	-1.3	-0.2	1.1	-1.0	-0.3
Crohns Disease (2017)	0.3	0.7	2.5	0.2	-0.1	0.2	0.6	-1.6	0.6	-1.3
Irritable Bowel Disease (IBD)	0.7	1.6	5.9	-0.9	-0.8	0.1	0.5	-1.9	-0.2	-2.4
Ulcerative Colitis (UC)	0.9	1.7	4.9	-1.4	-0.8	-0.1	0.2	-2.0	-0.5	-2.2
Major Depression (MDD)	1.9	2.3	11.3	-0.7	0.4	-0.8	-0.9	3.4	-1.0	1.2
Reaction Time	2.1	3.9	9.2	-2.2	-1.8	0.2	0.0	-3.0	-2.3	-2.3
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.3	-1.1	0.2	-0.8	-0.9	0.2	-0.7	0.3
Breast Cancer	0.6	1.5	3.7	1.9	-1.7	-0.1	-0.5	1.2	1.4	-0.2
Ovarian Cancer	1.5	1.9	5.3	1.4	1.1	2.3	2.0	0.2	1.0	0.0
Prostate Cancer	0.2	0.3	1.0	0.7	0.6	0.3	-0.1	-0.1	1.0	0.5
Age at First Birth	0.3	0.4	0.8	-0.7	-0.9	-0.1	-0.4	0.8	-0.8	-0.2
Bipolar Disorder (2011)	2.0	1.9	3.8	1.6	0.8	1.9	1.5	-0.8	1.8	0.4
Body Mass Index (BMI) (2010)	1.0	1.3	4.7	0.6	1.3	-0.5	0.6	1.2	0.6	2.2
Coronary Artery Disease (CAD)	2.2	2.7	7.7	-0.8	-2.8	-1.9	-2.0	-0.2	-0.4	-1.6
Crohns Disease (2012)	0.6	1.0	1.9	0.9	1.1	0.9	0.9	-1.4	1.2	0.2
Mean Putamen Volume	1.0	1.2	3.2	0.6	1.6	0.7	1.8	0.1	0.9	0.8
Fasting Glucose	1.5	1.8	7.3	0.2	0.8	2.7	1.7	-0.4	1.1	0.1
HbA1C	0.5	0.6	2.6	0.0	1.6	-0.4	0.4	0.6	0.2	1.0
HDL Cholesterol	1.4	2.4	7.5	-0.3	2.0	0.6	0.1	2.7	-1.1	1.9
LDL Cholesterol	0.3	0.5	1.3	-0.6	0.5	-0.6	0.9	-1.1	-0.6	0.1
Lupus	2.1	3.2	8.1	-2.9	-1.5	0.2	-0.9	-0.2	-2.3	-2.3
Neuroticism (2016)	1.2	1.8	5.1	-1.9	0.4	-1.6	-0.7	0.8	-2.3	-0.3
Primary Biliary Cirrhosis	1.7	2.4	6.6	1.6	1.3	2.6	1.9	-0.1	1.3	0.8
Rheumatoid Arthritis	0.2	0.3	0.9	1.0	-0.3	-0.0	0.4	0.6	0.5	0.1
Schizophrenia (2014)	1.0	2.3	6.2	0.9	1.6	2.5	1.8	0.3	1.4	1.0
Triglycerides	0.6	1.0	2.9	0.4	0.5	0.9	1.6	-1.7	0.5	0.5
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.7	0.6	1.3	0.5	1.0	-0.9	1.1	1.0
Ulcerative Colitis	0.5	0.8	3.1	-0.6	-0.2	0.3	0.5	-1.3	-0.0	-1.7
Blood Eosinophil Count	0.1	0.8	3.0	-0.2	0.0	1.7	0.7	-1.3	-0.4	-0.6
Blood Platelet Count	0.0	0.2	0.5	0.1	-0.6	0.2	0.7	0.3	0.3	-0.7
Blood Red Count	0.8	8.1	14.4	-3.0	-3.8	-3.0	-2.9	-1.2	-2.5	-2.9
Blood White Count	0.1	0.8	2.9	0.6	-0.2	1.7	0.7	-0.9	0.8	-0.0
Heel T-Score	0.3	2.1	6.6	1.6	0.8	1.2	0.3	2.6	1.1	1.4
BMI	0.8	4.5	15.5	-1.7	-3.9	-0.8	-0.7	-1.8	-1.4	-2.6
Height	0.4	7.1	27.9	-2.7	1.3	-5.3	-2.1	-0.2	-2.8	-0.4
Waist Hip Ratio (WHR)	0.2	1.0	3.1	-0.3	0.5	1.8	0.5	1.7	0.2	0.4
Systolic Blood Pressure	0.3	1.4	7.8	-0.6	-0.2	-0.6	-2.8	-0.4	-0.6	0.9
Smoking Status	0.0	0.1	0.3	0.3	-0.0	0.0	0.5	0.1	0.2	-0.5
Allergy or Eczema	0.4	0.9	2.1	-1.2	-1.3	1.0	-0.1	-0.3	-0.4	-1.4
Cardiovascular Disease	0.3	0.9	1.6	-1.1	-0.6	0.2	-1.3	-1.2	-1.3	-0.3
Hypothyroidism (self reported)	1.5	3.4	9.0	1.1	1.3	3.0	2.9	-1.2	1.4	0.6
Respiratory disease	0.6	1.3	2.4	-1.4	-1.5	-0.4	-1.0	0.4	-1.4	-1.3
Type 2 Diabetes (T2D) (2018)	0.7	1.3	4.1	-0.5	-1.9	0.1	-1.0	-0.3	-0.3	-2.0
Lung FEV1/FVC ratio	0.2	0.8	1.9	1.1	0.6	1.4	0.3	-1.1	1.1	-0.1
Lung FVC	0.6	3.3	8.1	1.1	2.8	0.7	1.4	1.8	1.4	2.5
Neuroticism	0.3	0.6	1.6	-1.0	-0.0	-0.5	-0.6	-0.1	-1.1	-1.3
Chronotype (morning person)	2.6	6.0	14.1	-2.1	-3.8	-1.4	-2.6	-1.0	-2.6	-2.7
Hair Pigment	0.2	4.7	11.1	0.9	2.2	-2.1	-2.5	2.2	0.7	3.3
Tanning	0.1	1.2	2.8	-1.7	-1.0	-0.3	-1.1	-0.4	-1.5	-1.0
Hand grip strength (left)	0.3	0.8	1.9	-0.3	-0.3	-0.9	-0.8	1.4	-0.1	1.3
Number of treatments/medications taken	2.7	4.8	10.6	-1.7	-3.3	1.0	-0.3	-2.2	-1.8	-3.2
Average weekly spirits intake	0.5	0.6	1.6	0.1	-1.2	-0.6	-1.2	0.0	-0.3	-0.6
Sensitivity / hurt feelings	0.5	0.8	2.6	-0.6	-1.1	-0.3	-0.0	-0.9	-0.5	-1.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.7	-0.8	0.5	1.3	1.3	-0.3	-0.8	-0.1
Hearing difficulty/problems: Yes	0.4	0.6	3.1	0.4	-0.3	1.8	0.3	-0.3	0.5	-0.7
Relative age of first facial hair	0.2	0.4	2.1	-0.3	-1.4	-0.7	-0.3	0.1	-0.1	-0.4
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.7	-1.2	-1.6	0.4	-1.3	0.4	-0.6	-1.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.0	0.4	0.4	-0.3	-0.3	-0.0	0.2
Ever had hysterectomy (womb removed)	0.5	0.6	2.1	-0.3	1.5	0.6	0.8	-0.7	-0.5	-0.0
Systolic blood pressure, automated reading	0.5	1.6	6.3	-0.7	-0.8	-1.1	-2.5	0.7	-1.2	0.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.6	-0.5	-1.1	0.0	0.9	0.1	-0.6	-1.3
Angina	0.3	0.5	1.7	0.5	-0.3	1.0	0.0	1.3	0.3	0.2
Medication for hormone replacement therapy	0.6	0.6	2.2	-0.5	-0.2	-1.5	-0.5	-0.6	-1.0	-0.6
Vitamin and mineral supplements	0.3	0.4	0.9	0.8	0.2	-0.8	0.3	1.0	0.9	0.0
Supplements: Zinc	0.6	0.6	1.9	0.2	1.0	1.1	1.4	-0.2	0.1	0.3
Medication: Co-codamol	0.7	0.8	2.1	0.1	0.8	0.6	0.4	1.4	0.1	1.5
Medication: Metformin	0.3	0.5	1.0	1.0	-0.9	-0.5	-0.5	0.6	0.9	-0.2
Diabetes (father)	0.3	0.4	1.0	-1.0	-0.3	-0.6	-0.5	0.0	-0.7	-0.5
Diabetes (mother)	1.0	1.2	2.8	1.1	0.0	1.3	1.7	-1.4	1.0	-0.2
Severe depression (siblings)	0.5	0.6	1.2	1.1	-1.0	0.9	-0.5	0.3	0.7	-0.3
Pack years adult smoking proportion	0.3	0.4	1.8	0.4	-0.2	-0.4	-0.7	-0.4	0.2	1.4
Impedance of leg (right)	0.2	1.1	3.3	1.1	1.8	0.8	1.2	0.2	0.8	0.7
Leg fat-free mass (left)	0.5	2.7	7.7	-1.6	-1.5	-2.8	-1.3	-1.3	-1.3	-1.2
Trunk fat percentage	0.7	2.8	6.4	-1.6	-2.5	-0.5	-0.8	-1.0	-1.9	-2.2
Hand grip strength (right)	0.3	0.9	2.9	-0.5	0.6	-0.6	-0.5	1.3	-0.2	1.7
Townsend deprivation index at recruitment	0.6	0.8	2.4	0.9	-1.4	0.4	0.2	0.5	-0.1	-1.6
Current tobacco smoking	0.3	0.5	1.0	0.8	-0.5	-0.9	0.2	1.0	0.5	0.4
Average weekly fortified wine intake	0.4	0.5	1.0	-0.1	-0.8	-1.0	-0.7	-0.7	0.1	-0.6
Maternal smoking around birth	3.4	4.9	9.1	-3.0	-1.9	-2.4	-2.5	-0.6	-2.3	-1.9
Fed-up feelings	0.3	0.5	1.2	-0.6	0.7	-0.2	1.1	-0.5	-1.0	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.7	6.2	0.1	1.3	1.7	2.5	0.5	-0.3	0.6
Relative age voice broke	0.2	0.3	1.2	0.1	-1.1	-0.1	-0.7	0.1	0.0	-0.5
Taking other prescription medications	1.3	2.0	6.0	-0.7	-2.5	1.1	-0.7	-0.8	-1.2	-2.0
Age when periods started (menarche)	0.1	0.2	0.7	-0.9	0.7	-0.2	0.2	-0.2	-0.5	-0.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.2	-1.1	0.5	-0.6	0.0	0.3	-1.1	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.5	1.5	1.3	0.7	0.6	1.2	1.6	0.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.7	0.2	0.8	-0.9	-0.9	0.2	-0.3	1.3
Qualifications: CSEs or equivalent	0.2	0.2	0.4	0.4	-0.5	0.6	0.1	-0.6	-0.1	-0.6
Serious illness, injury or assault to yourself	0.9	1.0	2.1	-0.7	-1.4	-0.8	-1.4	-1.3	-0.6	-0.3
High blood pressure	0.6	1.8	3.3	-1.5	-1.7	-0.6	-1.8	-0.8	-1.4	-1.0
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.8	-0.9	-1.4	0.0	-0.5	-0.8	-0.2	-0.8
Multivitamins +/- minerals	0.3	0.4	1.1	-0.5	0.5	0.0	-0.7	-1.0	-0.7	0.7
Stomach or abdominal pain in last month	0.8	1.0	2.6	-1.6	-0.7	-0.2	-0.4	0.3	-1.6	-1.1
Supplements: Glucosamine	0.7	0.9	1.3	-1.0	-0.9	-0.9	-1.1	0.4	-0.8	-1.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	2.7	-0.5	-1.5	-1.5	-1.7	0.1	-0.3	-0.7
Medication: Atenolol	0.6	0.8	3.3	0.6	0.1	1.8	0.1	1.1	0.7	0.5
Medication: Levothyroxine sodium	0.7	1.2	4.5	-0.2	0.5	1.7	2.1	-0.9	-0.0	-0.2
Sitting height	0.8	5.5	13.8	-2.9	0.9	-3.7	-2.0	0.8	-3.0	-1.4
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	-0.1	-1.0	-0.6	-0.7	0.3	-0.3	0.5
High blood pressure (mother)	0.7	1.0	1.9	1.4	1.2	0.2	0.3	-1.4	1.2	0.3
Body mass index (BMI)	0.5	2.2	9.1	-1.0	-3.0	-0.2	-0.6	-1.3	-0.8	-1.7
Impedance of leg (left)	0.2	0.9	3.6	0.6	1.9	0.4	1.0	0.9	0.1	0.8
Leg predicted mass (left)	0.5	2.8	8.0	-1.7	-1.5	-2.8	-1.4	-1.2	-1.4	-1.1
Trunk fat mass	0.9	3.8	6.2	-2.2	-2.5	-1.4	-1.1	-1.3	-2.4	-2.3
Waist circumference	0.6	2.2	6.8	-1.5	-2.6	-0.6	-1.0	-0.7	-1.3	-1.6
Number of incorrect matches in round	0.4	0.6	3.6	-0.6	-0.4	-0.2	0.3	-1.9	-0.2	-0.0
Past tobacco smoking	0.5	1.0	2.8	0.8	0.7	0.2	-0.3	1.7	1.0	1.4
Alcohol usually taken with meals	0.6	1.0	2.4	-0.4	-1.5	0.9	-1.1	0.6	-1.3	-0.6
Nervous feelings	0.2	0.4	1.0	-1.0	0.3	-0.4	-0.3	-0.5	-1.0	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	6.3	-1.0	1.2	2.5	1.7	-1.2	-1.2	-0.8
Hearing difficulty/problems with background noise	0.6	1.0	4.6	0.8	-0.2	2.1	0.4	1.0	0.4	-0.5
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.6	-0.3	-0.4	-0.7	-0.6	0.9	0.7
Had menopause	0.3	0.4	1.8	0.4	-0.4	-1.3	-0.0	-0.5	0.5	0.4
Had other major operations	0.3	0.4	1.3	0.1	0.3	0.0	1.1	-0.7	1.0	0.1
Forced vital capacity (FVC)	0.3	1.0	2.8	-0.6	1.7	-1.6	0.4	-0.4	0.7	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	4.1	1.0	1.3	0.5	0.2	2.0	0.7	0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.9	0.6	-0.5	0.6	0.7	0.9	0.7	-0.5
Qualifications: None of the above	0.7	1.4	3.0	-0.9	-1.1	-0.4	-1.0	-1.7	-1.6	-1.2
Financial difficulties in last 2 years	0.7	1.0	3.8	-1.4	0.0	0.0	-0.5	0.8	-1.9	-0.5
Mouth/teeth dental problems	0.5	0.8	1.4	0.7	0.3	-1.1	0.3	1.2	0.7	1.2
Heart attack	0.9	1.1	2.3	-1.2	-0.9	1.2	-1.3	-0.1	-1.5	-0.5
Allergy	1.0	2.3	3.7	1.8	1.8	-0.4	1.1	1.0	1.8	1.9
Pain all over the body in last month	0.7	0.7	2.0	-0.5	-1.1	-0.5	-1.4	0.2	-0.6	-0.9
Diabetes (self-reported)	1.8	2.7	8.5	-1.4	-2.3	-0.3	-1.3	-0.7	-0.9	-2.9
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.4	0.8	-0.3	1.2	0.2	-0.8	0.8	-0.1
Medication: Ramipril	0.4	0.5	1.5	0.6	-0.9	1.2	-0.7	-0.0	0.7	0.4
Medication: Simvastatin	0.7	1.1	3.0	-0.9	-1.2	0.5	-0.8	-1.0	-0.4	-1.7
Fluid intelligence score	0.5	1.1	3.0	-0.1	1.6	0.5	-0.2	1.2	0.3	1.7
Illnesses of siblings	1.0	1.3	4.0	0.2	2.0	0.9	0.9	-0.3	0.5	1.8
Neuroticism score	0.5	1.1	2.3	-1.5	0.2	-0.2	0.4	-0.9	-1.5	-1.4
Weight	0.6	3.1	5.3	-2.0	-2.0	-2.3	-1.1	-1.2	-1.8	-1.6
Impedance of arm (right)	0.0	0.2	0.7	0.2	0.8	0.6	0.5	0.2	-0.0	-0.5
Arm fat percentage (right)	0.8	3.1	9.9	-1.2	-3.1	-0.1	-0.2	-1.5	-1.1	-2.6
Trunk fat-free mass	0.9	5.0	17.0	-2.7	-0.3	-4.1	-1.7	-1.3	-2.3	-0.7
Hip circumference	0.5	2.0	4.2	-1.2	-2.1	-1.3	-0.5	-1.5	-1.1	-1.6
Time employed in main current job	0.5	0.6	2.4	0.0	0.4	-0.3	0.5	1.0	0.4	1.6
Alcohol intake versus 10 years previously	1.3	2.0	4.2	-0.8	-2.1	-1.5	-0.8	0.9	-1.5	-1.8
Father’s age at death	1.4	1.9	4.8	-1.6	-2.2	-1.1	-0.7	-0.1	-0.9	-1.9
Worrier / anxious feelings	0.2	0.4	1.2	-0.8	0.8	0.1	-0.0	0.3	-1.1	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.8	-0.4	-0.3	1.2	1.3	0.0	-0.7	-0.3
Falls in the last year	0.3	0.4	2.1	-0.6	0.4	-0.3	-0.1	-1.4	-0.4	-0.4
Hair/balding pattern: Pattern 3	0.8	1.2	4.0	-1.4	-0.5	-0.2	0.9	-0.2	-1.2	-2.0
Number of live births	1.3	1.9	3.8	1.5	0.6	1.2	-0.4	1.6	1.6	1.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	3.9	0.0	2.0	-0.9	0.6	-0.2	1.0	1.1
Pulse rate	1.6	2.7	6.7	-2.3	-0.7	-1.5	-1.8	0.1	-2.6	-0.6
Happiness	1.6	2.0	5.1	-1.5	0.1	-1.8	-1.5	2.3	-1.0	0.2
Noisy workplace	0.3	0.4	0.7	-0.0	-0.8	-0.0	-0.7	-0.3	-0.8	-0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.0	-0.1	1.0	0.5	1.0	-0.1	0.6	-0.0
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.4	4.3	-0.9	-0.8	0.4	0.3	-2.1	-0.7	-1.8
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	0.4	0.3	0.8	0.4	0.1	-0.1	-0.5
Asthma	1.5	2.9	5.2	-1.9	-2.0	-0.6	-1.4	-1.1	-1.9	-2.3
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	7.2	-1.2	-2.1	-0.8	-1.6	-0.8	-1.5	-2.7
Medication: Cholesterol lowering	0.8	1.3	2.5	-1.2	-1.6	-0.1	-1.2	-0.8	-0.8	-1.6
Depression (self-reported)	1.6	1.9	4.8	-0.7	-0.5	2.0	1.2	-1.4	-0.4	-2.2
Medication: Lansoprazole	1.1	1.2	4.2	-1.7	-0.4	-0.4	-0.6	0.1	-2.1	-0.8
Prospective memory result	0.2	0.3	1.1	0.4	-0.2	-0.1	-0.0	-0.7	0.1	-1.0
Lung cancer (father)	2.8	3.3	5.9	1.9	1.5	1.6	2.4	-1.7	2.2	1.1
Illnesses of mother	1.4	1.7	9.0	-0.8	-0.4	-0.4	-1.0	3.0	-1.0	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	4.0	-0.4	2.0	-1.1	0.4	-1.0	0.4	0.7
Pulse wave Arterial Stiffness index	0.6	0.7	2.3	-0.4	0.0	-0.5	-1.2	1.5	0.0	0.7
Impedance of arm (left)	0.1	0.4	0.7	0.6	0.7	0.8	0.7	0.3	0.4	-0.7
Arm fat mass (right)	0.8	3.2	7.7	-1.7	-2.8	-1.1	-0.5	-1.6	-1.6	-2.3
Trunk predicted mass	0.9	4.9	17.2	-2.6	-0.3	-4.1	-1.8	-1.2	-2.3	-0.6
Standing height	0.6	6.1	24.9	-2.5	2.1	-5.0	-1.2	-0.3	-2.5	0.2
Length of working week for main job	0.3	0.4	0.9	0.3	-0.8	-1.0	-0.9	0.4	0.0	-0.2
Exposure to tobacco smoke at home	0.4	0.4	1.2	0.2	0.0	-0.8	1.0	-1.1	0.2	-0.2
Breastfed as a baby	0.4	0.5	1.5	-0.8	0.4	1.2	0.7	-0.2	-0.9	0.1
Tense / ‘highly strung’	1.0	1.7	4.0	-1.9	-0.9	-0.4	-0.9	0.9	-2.0	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.1	-0.7	-1.0	1.2	-0.0	1.0	-0.6	-1.4
Hair/balding pattern: Pattern 4	0.4	1.0	2.7	1.7	1.0	0.5	0.6	0.5	1.5	0.1
Birth weight of first child	1.1	2.0	3.9	-2.0	1.1	-2.0	-0.6	0.1	-1.9	-0.7
Peak expiratory flow (PEF)	0.5	1.2	2.8	1.0	1.7	0.7	0.9	-0.6	1.6	0.6
Pulse wave reflection index	0.8	0.9	2.2	0.3	0.6	1.4	0.4	1.5	1.1	0.6
Ever highly irritable/argumentative for 2 days	1.4	1.7	2.9	-1.4	-1.2	-1.1	-0.3	1.1	-1.6	-1.7
Loud music exposure frequency	0.4	0.4	1.4	0.8	-0.0	1.2	-0.2	0.1	0.4	0.7
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.3	0.6	1.5	1.0	0.1	0.5	1.0	1.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.3	-0.2	1.0	0.7	0.6	-1.1	-0.2	0.6
Blood clot in the leg (DVT)	0.3	0.4	1.4	-0.6	0.9	-0.2	0.0	-0.2	-1.2	0.4
Medication: Paracetamol	1.2	2.0	7.6	-0.3	-2.2	0.0	-0.1	-1.0	-0.6	-2.8
Headache pain in last month	0.3	0.6	2.2	-0.2	-1.2	0.0	0.4	0.0	-0.4	-1.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	1.7	1.3	1.1	-0.5	0.9	1.3	1.0	0.9
Glaucoma (self-reported)	0.8	0.9	3.8	0.4	-0.0	1.9	0.2	-1.3	0.1	-0.9
Gout (self-reported)	0.7	1.0	2.5	1.4	-1.5	0.3	-0.4	0.4	1.6	-0.1
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	7.0	0.9	0.6	2.6	2.6	-1.1	1.0	-0.0
Medication: Amlodipine	0.5	0.8	2.6	-1.0	-0.0	0.1	-1.6	-0.1	-0.8	1.1
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.4	-0.7	-1.2	-0.5	-0.9	-0.8	-0.6	-0.6
Birth weight	0.4	0.8	2.0	-0.8	1.4	-0.5	1.2	0.7	-0.7	-0.4
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.9	-0.6	-1.0	-0.2	-0.5	-2.0	0.1	-0.1
High blood pressure (siblings)	0.4	0.6	1.3	1.1	-1.1	0.4	-0.2	0.1	0.8	-0.8
Forced vital capacity (FVC), Best measure	0.3	1.1	3.9	-0.5	2.0	-1.4	0.2	-0.1	0.2	1.1
Body fat percentage	0.7	2.6	7.8	-1.3	-2.8	-0.1	-0.4	-1.2	-1.5	-2.2
Leg fat percentage (right)	0.4	1.6	6.5	-0.2	-2.5	0.2	0.4	-1.3	-0.1	-1.6
Arm fat-free mass (right)	0.6	2.9	9.7	-1.9	-0.6	-3.1	-1.3	-0.8	-1.9	-0.6
Exposure to tobacco smoke outside home	0.4	0.5	2.1	0.4	1.5	-0.3	0.8	-0.4	0.0	0.8
Comparative body size at age 10	0.5	1.4	3.3	1.1	0.8	0.4	1.5	-1.8	1.4	0.6
Number of full brothers	0.5	0.7	1.6	-0.5	-1.3	-0.4	-0.6	0.5	-0.9	-1.1
Worry too long after embarrassment	0.8	1.3	3.7	-1.0	-0.6	-0.7	-0.5	-1.9	-0.3	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.2	-0.4	-0.4	0.5	0.8	0.3	-0.7	-1.1
Wheeze or whistling in the chest in last year	0.9	1.6	3.5	-1.8	-0.6	0.4	0.6	-1.2	-1.5	-1.9
Number of children fathered	0.5	0.6	1.2	0.5	-0.5	0.8	0.7	-1.0	0.6	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	6.7	-1.2	-0.6	-2.0	-2.6	0.1	-1.3	0.6
Age at first live birth	0.4	0.8	1.5	-0.7	-1.1	-0.5	-1.2	0.9	-0.6	-1.0
Pulse wave peak to peak time	0.4	0.5	1.9	0.1	0.1	0.0	0.9	-1.4	-0.2	-0.6
Health satisfaction	0.2	0.3	0.6	-0.8	-0.2	-0.3	0.1	0.8	-0.7	-0.6
Shortness of breath walking on level ground	0.7	0.8	2.0	-1.0	-1.4	0.1	-0.0	0.3	-0.8	-1.4
Qualifications: College or University degree	0.1	0.4	0.9	-0.9	-0.6	0.1	-0.2	0.9	-1.0	-0.4
Eye problems/disorders: None of the above	0.6	0.7	2.4	0.2	0.9	-0.3	0.5	0.5	0.9	1.6
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.0	-0.4	1.4	0.2	-0.5	-1.3	-1.4	0.4
Emphysema/chronic bronchitis	1.2	1.3	4.9	-1.0	-0.6	2.2	0.4	0.6	-1.3	-0.8
Medication for pain relief, constipation, heartburn	2.0	3.3	12.3	0.6	2.7	-0.3	0.6	1.6	0.8	3.5
Neck or shoulder pain in last month	0.7	1.0	2.1	-0.2	-1.1	-1.3	-0.9	-0.7	-0.5	-1.5
Medication: Blood pressure	0.7	1.2	1.9	-1.2	-1.2	1.3	-1.2	-1.4	-0.8	-0.5
Angina (self-reported)	0.3	0.4	1.5	0.4	-0.8	0.7	-0.3	1.2	0.3	-0.1
Migraine (self-reported)	0.2	0.2	0.7	0.8	-0.4	0.2	0.5	0.3	0.6	0.1
Medication: Ibuprofen	1.2	1.5	5.2	-0.6	-1.7	-0.2	-0.9	-0.7	-0.6	-2.3
Medication: Allopurinol	1.1	1.5	5.5	1.8	-0.4	0.4	-0.1	-0.3	2.4	1.0
Medication: Omeprazole	1.2	1.4	3.7	-0.2	-1.9	-1.0	-1.0	-0.2	-1.1	-1.8
Medication: Seretide 50 evohaler	0.7	0.8	3.6	-0.5	-1.1	1.9	0.3	-0.1	-0.5	-0.7
Mean time to correctly identify matches	1.7	3.2	6.5	-2.3	-1.6	1.0	-0.0	-2.0	-2.5	-1.9
Heart disease (mother)	0.7	0.8	4.6	-0.2	0.5	0.7	0.7	-2.1	0.3	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.8	-1.2	-0.9	-0.3	-1.2	-0.5	-1.3	-1.1
Whole body fat mass	0.8	3.3	7.0	-1.9	-2.6	-1.2	-0.7	-1.5	-2.0	-2.2
Leg fat mass (right)	0.7	2.8	8.5	-1.2	-2.9	-0.8	-0.4	-1.7	-1.1	-2.1
Arm predicted mass (right)	0.7	3.3	11.1	-2.2	-0.5	-3.3	-1.4	-0.7	-2.1	-0.5
Pulse rate, automated reading	2.4	7.7	15.5	-3.9	-1.4	-3.0	-3.0	-0.7	-3.9	-1.4
Alcohol intake frequency.	0.6	1.3	5.3	0.1	-1.8	-2.3	0.0	-0.2	-0.1	-0.7
Comparative height size at age 10	0.1	0.8	2.8	-0.5	0.7	-1.7	-0.2	-0.7	-1.0	-0.8
Number of full sisters	0.3	0.4	0.8	0.8	-0.9	-0.6	-0.2	0.6	0.6	0.0
Suffer from ‘nerves’	0.3	0.5	1.0	-0.5	0.6	0.8	0.9	0.4	-1.0	-0.7
Overall health rating	0.2	0.4	1.2	-0.2	-0.5	0.9	1.1	0.0	-0.6	0.1
Chest pain or discomfort	0.5	0.7	1.9	-1.2	-0.2	-0.1	0.7	-1.4	-1.1	-0.3
Had major operations	0.8	1.0	3.0	-1.2	-0.5	-0.5	-1.7	0.2	-1.1	-0.8
Age at last live birth	0.6	0.9	3.1	-0.8	-1.2	0.2	-1.8	0.6	-0.5	-0.8
Family relationship satisfaction	0.5	0.6	1.5	-0.9	-0.4	-1.2	-0.9	0.7	-0.7	-0.2
Leg pain on walking	0.4	0.5	1.5	-0.5	-0.9	-0.8	0.2	-1.2	-0.2	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.8	-0.0	0.6	1.3	1.0	-0.4	0.3	0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.3	0.4	0.1	-0.5	0.3	0.3	0.7	1.1
Illness, injury, bereavement, stress in last 2 years	3.0	3.6	8.5	2.3	1.6	1.7	2.1	-0.1	2.9	1.3
Medication: Aspirin	0.6	0.7	2.7	-0.3	-1.6	0.2	-0.3	-0.9	-0.0	-1.2
Supplements: Vitamin C	0.8	0.9	3.2	0.5	0.0	1.8	-0.2	1.1	0.1	1.2
Knee pain experienced in last month	0.6	1.0	3.3	-0.7	-1.8	-0.5	-1.0	0.5	-0.9	-0.9
Hypertension (Self-reported)	0.4	1.1	2.8	-1.1	-1.3	0.1	-1.7	-0.7	-1.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.2	-1.5	-0.4	-0.4	-1.3	0.3	-2.0	-0.6
Illnesses of father: Heart disease	1.1	1.5	3.3	-1.0	-1.1	-1.7	-1.8	-0.5	-1.2	-0.8
Illnesses of siblings: Diabetes	0.3	0.3	0.7	-0.5	-0.0	-0.7	-0.1	0.4	-0.9	-0.9
Smoking status: Previous	1.0	1.4	3.7	-1.1	-0.8	-0.4	0.2	-1.9	-1.3	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.9	-0.7	0.8	-0.4	1.0	-0.7	-0.3	-0.7
Whole body fat-free mass	0.7	3.8	13.0	-2.3	-0.7	-3.6	-1.5	-1.1	-2.0	-0.7
Leg fat-free mass (right)	0.6	3.0	8.8	-1.9	-1.4	-3.0	-1.5	-0.7	-1.7	-1.0
Arm fat percentage (left)	0.8	3.2	11.1	-1.1	-3.3	0.1	-0.3	-1.3	-1.0	-2.8
Average weekly red wine intake	0.2	0.3	0.8	-0.1	0.5	-0.6	0.7	-0.2	-0.9	0.1
Handedness (chirality/laterality): Left-handed	1.4	1.7	4.3	-1.6	-0.8	-2.1	-1.2	0.6	-1.6	-0.5
Mood swings	0.7	1.2	4.7	-0.5	-1.2	-1.0	-0.4	-0.7	-0.5	-2.2
Loneliness, isolation	0.7	1.0	2.6	-1.6	-0.5	-0.5	-0.1	0.2	-1.6	-1.1
Long-standing illness, disability or infirmity	2.4	3.7	11.4	-0.7	-3.4	0.3	-0.5	-2.2	-0.3	-2.9
Ever had bowel cancer screening	2.3	2.7	5.8	-0.9	-2.4	-0.2	-1.8	0.5	-1.8	-2.3
Diabetes diagnosed by doctor	1.2	1.9	6.2	-0.6	-2.3	-0.2	-1.1	-0.8	-0.2	-2.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.1	0.9	-1.5	0.5	-1.2	0.2	0.7	-0.4
Friendships satisfaction	0.9	1.1	4.5	-0.1	1.4	0.6	0.4	2.1	-0.1	1.0
Qualifications: nursing, teaching	1.2	1.9	5.2	1.9	0.8	1.3	0.9	0.4	2.3	0.9
Commuting to job workplace: Walk	0.8	0.8	2.3	1.5	0.9	0.3	0.5	0.3	1.0	1.1
Eye problems/disorders: Cataract	0.6	0.7	1.3	0.8	-0.3	0.8	1.2	-0.9	0.4	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.5	-0.7	-1.3	-0.1	-0.3	-0.0	-0.3	-1.6
Medication for cholesterol	1.0	1.6	3.0	0.5	1.7	0.8	1.4	1.4	1.0	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.4	1.5	-0.2	0.7	0.4	0.3	1.6	0.4
Back pain experienced in last month	0.4	0.6	1.4	-0.9	-0.0	-0.5	0.4	-1.2	-0.8	-1.0
Mineral and other dietary supplements	1.9	2.5	6.9	2.6	1.5	1.0	0.8	1.0	2.0	1.4
Breast cancer (self-reported)	0.2	0.3	0.4	0.5	0.7	0.6	-0.2	0.2	0.6	0.6
Asthma (self-reported)	1.5	2.9	4.6	-2.1	-1.9	-0.7	-1.5	-1.1	-2.0	-2.1
Osteoporosis (self-reported)	0.6	0.8	2.7	-1.6	0.3	-0.5	-1.0	-0.1	-1.1	-0.0
Osteoarthritis (self-reported)	0.7	0.9	2.3	-1.3	-1.5	-0.1	-1.1	0.3	-1.0	-0.6
Medication: Aspirin	0.7	0.9	3.7	-0.4	-1.9	-0.2	-0.3	-0.5	-0.2	-1.5
Medication: Gliclazide	0.2	0.2	0.6	-0.5	-0.2	-0.1	-0.8	0.4	-0.4	-0.1
Illnesses of father: None of the above (group 1)	3.9	4.8	9.9	2.5	1.1	2.8	3.2	-0.3	2.9	-0.0
Smoking status: Current	0.3	0.4	1.1	0.9	-0.3	-0.7	0.2	1.0	0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	4.2	1.6	1.9	0.4	0.9	-0.0	2.0	1.3
Whole body water mass	0.7	4.0	13.4	-2.3	-0.7	-3.7	-1.6	-1.1	-2.1	-0.8
Leg predicted mass (right)	0.6	3.0	9.2	-1.9	-1.4	-3.0	-1.4	-0.7	-1.7	-1.0
Arm fat mass (left)	0.8	3.2	8.0	-1.6	-2.8	-1.2	-0.7	-1.5	-1.4	-2.3
Number of self-reported non-cancer illnesses	1.9	3.4	7.5	-1.6	-2.7	0.4	-1.7	-0.5	-1.8	-2.6
Average weekly champagne plus white wine intake	0.5	0.7	1.5	-1.2	-1.2	1.1	-0.3	-0.3	-0.8	-0.6
Miserableness	1.0	1.8	4.4	-2.1	0.9	-0.0	1.1	-0.1	-1.7	-1.7
Guilty feelings	0.6	0.9	2.3	-0.9	-1.1	-0.2	0.0	-1.1	-0.9	-1.5
Wears glasses or contact lenses	1.4	1.6	4.8	0.1	1.5	1.6	2.2	-0.1	0.2	1.1
Ever taken oral contraceptive pill	0.3	0.4	1.3	-0.2	0.5	1.1	0.8	0.3	0.4	-0.3
Hearing aid user	1.0	1.1	2.6	0.8	0.2	1.6	0.5	1.4	0.8	1.2
Mother’s age at death	0.5	0.6	2.6	-0.1	0.9	-0.5	-0.2	-1.6	-0.2	0.7
Financial situation satisfaction	0.5	0.7	1.9	-1.1	0.0	-1.4	-0.6	0.2	-1.1	-0.3
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.6	-0.3	1.2	0.9	1.6	-0.8	-0.2	-0.1
Commuting to job workplace: Public transport	0.4	0.5	1.3	-0.5	1.1	0.4	-0.2	0.9	-0.7	0.8
Eye problems/disorders: Glaucoma	0.8	0.9	2.5	0.8	0.2	1.6	0.2	-1.6	0.2	-0.9
Medication: Blood pressure	0.4	0.8	3.3	0.2	-1.8	-0.1	-1.5	-0.5	0.0	-0.5
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.2	-1.2	-0.8	-0.2	0.1	0.1	-0.7	-1.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.5	-1.9	-0.6	-0.5	-0.5	-0.9	-1.1	-0.1
High cholesterol (Self-reported)	0.4	0.7	1.2	-0.7	-0.8	1.1	-0.7	-0.2	-0.9	-1.0
Medication: Bendroflumethiazide	0.5	0.7	2.0	-0.7	-0.8	-0.8	-1.4	-0.3	-0.9	-0.6
Medication: Paracetamol	1.2	1.8	5.8	0.1	-2.3	-0.1	-0.3	-1.1	0.1	-2.4
Medication: Lisinopril	0.8	1.0	2.0	-0.8	-1.4	0.6	-1.0	-1.2	0.1	-1.3
Medication: Atorvastatin	0.4	0.5	0.9	0.4	0.8	0.9	1.0	-0.1	-0.0	0.9
Illnesses of father: High blood pressure	1.1	1.4	4.8	-0.9	-1.0	-0.8	-2.2	0.1	-1.2	-1.1
Alcohol drinker status: Never	1.1	1.3	4.9	0.6	0.8	-2.2	-0.9	0.6	-0.2	1.3
Ever smoked	0.2	0.4	1.7	-0.1	-0.8	-0.5	0.2	-1.3	-0.1	-0.5
Basal metabolic rate	0.7	3.9	11.8	-2.3	-1.1	-3.4	-1.4	-1.2	-2.0	-1.1
Leg fat percentage (left)	0.4	1.4	6.4	-0.3	-2.5	0.0	0.2	-0.9	-0.5	-1.4
Arm fat-free mass (left)	0.5	2.6	10.2	-1.7	-0.3	-3.2	-1.0	-1.1	-1.6	-0.2
Number of operations (self-reported)	1.8	2.6	4.4	-2.1	-1.7	-0.7	-1.9	0.6	-1.6	-2.0
Average weekly beer plus cider intake	0.4	0.6	2.8	0.4	0.5	-1.7	-0.5	-0.3	0.3	0.5
Irritability	1.3	2.1	6.7	-2.3	0.0	-0.4	-0.3	-0.1	-2.6	-1.7
Risk taking	0.6	0.9	5.1	-0.4	1.0	0.1	0.5	-2.3	-0.0	0.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.4	-0.6	1.5	0.5	0.4	-1.4	-0.6	-0.7
Fractured/broken bones in last 5 years	0.3	0.4	1.4	-0.2	0.1	-0.3	1.0	-1.2	-0.2	-0.2
Age started oral contraceptive pill	1.1	1.4	2.6	-1.6	-0.0	-1.3	-1.5	-0.3	-1.6	-0.6
Diastolic blood pressure, automated reading	0.8	2.4	6.0	-0.4	0.8	-1.1	-1.8	2.4	-1.1	2.2
Ever depressed for a whole week	0.4	0.5	1.5	-0.7	0.6	-0.9	0.3	1.2	-0.3	0.1
Unable to work because of sickness or disability	0.3	0.5	1.9	0.1	0.6	0.2	1.4	-0.1	-0.3	0.8
Commuting to job workplace: Cycle	0.4	0.5	1.5	-0.1	0.5	0.6	-0.4	-0.9	-0.4	-1.2
Myopia	0.5	0.8	2.3	0.5	-1.5	-0.4	-0.0	0.2	0.7	-1.5
Vascular/heart problems diagnosed by doctor	0.6	1.7	2.5	1.5	1.5	0.2	1.6	1.1	1.6	1.0
Cholesterol lowering medication	0.5	0.8	2.2	-0.2	-0.9	1.5	0.4	-0.7	-0.2	-1.3
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.4	-0.9	-1.4	-1.2	-0.8	-0.1	-1.6	-1.4
Pain experienced in last month	0.9	1.4	4.4	1.1	1.2	-0.2	0.1	0.1	1.8	2.1
Supplements: Calcium	0.2	0.3	0.5	-0.7	0.1	-0.2	-0.7	0.4	-0.7	-0.5
Basal cell carcinoma (self-reported)	1.3	1.6	4.4	1.2	1.0	0.0	-1.2	1.2	1.0	2.1
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.6	-1.0	-0.9	1.2	-1.3	-0.1	-1.3	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.4	-1.0	0.8	-0.3	-0.2	-0.4	-1.5	0.1
Heart disease (siblings)	0.7	0.8	2.6	-0.9	-0.6	0.2	-0.4	-0.2	-1.6	-1.4
Alcohol drinker status: Previous	1.2	1.4	4.2	-1.2	-1.2	-0.7	1.0	-0.7	-0.9	-2.0
Pack years of smoking	0.2	0.4	1.2	0.1	-0.2	-0.6	-0.9	-0.3	-0.2	1.1
Impedance of whole body	0.2	0.9	2.9	0.7	1.7	0.9	1.1	0.7	0.3	0.3
Leg fat mass (left)	0.7	2.8	8.2	-1.3	-2.9	-1.0	-0.5	-1.6	-1.4	-2.1
Arm predicted mass (left)	0.7	3.6	12.7	-2.1	-0.4	-3.6	-1.4	-1.1	-2.1	-0.5