Hub : Genes

HPS3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Breast Invasive Carcinoma 0.1128 0.0414 1.4e-10 0.073 0.048 0.063 NA 0.072 1.1e-14 4.2e-10 7.5e-13 NA 1.7e-14
2 TCGA Kidney Renal Papillary Cell Carcinoma 0.1110 0.0480 2.4e-03 -0.004 0.023 0.003 NA 0.000 6.0e-01 1.7e-02 2.0e-01 NA 3.3e-01
3 TCGA Lung Adenocarcinoma 0.0532 0.0233 8.7e-04 0.017 0.016 0.019 NA 0.016 3.7e-03 4.3e-03 2.4e-03 NA 4.4e-03
4 TCGA Lung Squamous Cell Carcinoma 0.0666 0.0371 7.2e-03 0.010 0.013 0.023 NA 0.017 2.1e-02 1.1e-02 1.1e-03 NA 4.2e-03
5 TCGA Pheochromocytoma and Paraganglioma 0.1570 0.0680 1.7e-03 0.136 0.041 0.057 NA 0.114 4.7e-06 9.6e-03 2.8e-03 NA 2.8e-05
6 TCGA Prostate Adenocarcinoma 0.1485 0.0615 3.2e-04 0.056 0.034 0.033 NA 0.049 1.7e-06 1.5e-04 1.8e-04 NA 7.5e-06
7 TCGA Skin Cutaneous Melanoma 0.2160 0.0830 5.6e-04 0.105 0.138 0.060 NA 0.112 9.5e-04 1.6e-04 1.1e-02 NA 6.6e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.5 0.8 1.6 0.4 1.1 1.2 1.3 -0.1 0.9 0.1
Bipolar Disorder or Schizophrenia 0.9 2.1 5.8 1.0 1.3 2.4 1.8 -0.0 1.6 0.5
Depressed Affect (Nagel 2018) 0.1 0.3 1.0 -0.6 0.2 -0.0 -0.1 -0.7 -0.3 -1.0
Depression (Nagel 2018) 0.3 0.5 0.8 -0.3 0.9 0.4 0.6 0.9 -0.5 0.9
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.7 0.6 1.0 -0.1 0.3 0.2 1.0 1.3
Neuroticism (Nagel 2018) 0.2 0.4 1.6 -0.9 -0.5 -0.1 -0.3 -0.4 -0.5 -1.3
Schizophrenia (2018) 0.7 1.4 4.6 1.0 0.9 2.1 1.3 0.1 1.3 0.6
Schizophrenia vs Biploar Disorder 0.6 0.8 4.2 -0.2 -0.8 -0.2 -0.3 2.0 -0.4 0.4
Worry (Nagel 2018) 0.2 0.4 1.0 -1.0 0.5 0.5 -0.3 0.7 -0.8 -0.1
Alzheimer’s Disease (in mother) 0.6 0.7 3.8 -0.4 -0.3 0.3 0.7 2.0 -0.7 0.0
Alzheimer’s Disease (in father) 3.2 3.4 12.8 -1.4 -0.8 -3.6 -2.2 0.1 -1.6 -0.9
Alzheimer’s Disease (including proxy) 0.5 0.7 1.8 -0.8 -0.3 -1.3 -0.2 1.1 -1.0 -0.3
Crohns Disease (2017) 0.3 0.7 2.5 0.2 -0.1 0.2 0.6 -1.6 0.6 -1.3
Irritable Bowel Disease (IBD) 0.7 1.6 5.9 -0.9 -0.8 0.1 0.5 -1.9 -0.2 -2.4
Ulcerative Colitis (UC) 0.9 1.7 4.9 -1.4 -0.8 -0.1 0.2 -2.0 -0.5 -2.2
Major Depression (MDD) 1.9 2.3 11.3 -0.7 0.4 -0.8 -0.9 3.4 -1.0 1.2
Reaction Time 2.1 3.9 9.2 -2.2 -1.8 0.2 0.0 -3.0 -2.3 -2.3
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.3 -1.1 0.2 -0.8 -0.9 0.2 -0.7 0.3
Breast Cancer 0.6 1.5 3.7 1.9 -1.7 -0.1 -0.5 1.2 1.4 -0.2
Ovarian Cancer 1.5 1.9 5.3 1.4 1.1 2.3 2.0 0.2 1.0 0.0
Prostate Cancer 0.2 0.3 1.0 0.7 0.6 0.3 -0.1 -0.1 1.0 0.5
Age at First Birth 0.3 0.4 0.8 -0.7 -0.9 -0.1 -0.4 0.8 -0.8 -0.2
Bipolar Disorder (2011) 2.0 1.9 3.8 1.6 0.8 1.9 1.5 -0.8 1.8 0.4
Body Mass Index (BMI) (2010) 1.0 1.3 4.7 0.6 1.3 -0.5 0.6 1.2 0.6 2.2
Coronary Artery Disease (CAD) 2.2 2.7 7.7 -0.8 -2.8 -1.9 -2.0 -0.2 -0.4 -1.6
Crohns Disease (2012) 0.6 1.0 1.9 0.9 1.1 0.9 0.9 -1.4 1.2 0.2
Mean Putamen Volume 1.0 1.2 3.2 0.6 1.6 0.7 1.8 0.1 0.9 0.8
Fasting Glucose 1.5 1.8 7.3 0.2 0.8 2.7 1.7 -0.4 1.1 0.1
HbA1C 0.5 0.6 2.6 0.0 1.6 -0.4 0.4 0.6 0.2 1.0
HDL Cholesterol 1.4 2.4 7.5 -0.3 2.0 0.6 0.1 2.7 -1.1 1.9
LDL Cholesterol 0.3 0.5 1.3 -0.6 0.5 -0.6 0.9 -1.1 -0.6 0.1
Lupus 2.1 3.2 8.1 -2.9 -1.5 0.2 -0.9 -0.2 -2.3 -2.3
Neuroticism (2016) 1.2 1.8 5.1 -1.9 0.4 -1.6 -0.7 0.8 -2.3 -0.3
Primary Biliary Cirrhosis 1.7 2.4 6.6 1.6 1.3 2.6 1.9 -0.1 1.3 0.8
Rheumatoid Arthritis 0.2 0.3 0.9 1.0 -0.3 -0.0 0.4 0.6 0.5 0.1
Schizophrenia (2014) 1.0 2.3 6.2 0.9 1.6 2.5 1.8 0.3 1.4 1.0
Triglycerides 0.6 1.0 2.9 0.4 0.5 0.9 1.6 -1.7 0.5 0.5
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.7 0.6 1.3 0.5 1.0 -0.9 1.1 1.0
Ulcerative Colitis 0.5 0.8 3.1 -0.6 -0.2 0.3 0.5 -1.3 -0.0 -1.7
Blood Eosinophil Count 0.1 0.8 3.0 -0.2 0.0 1.7 0.7 -1.3 -0.4 -0.6
Blood Platelet Count 0.0 0.2 0.5 0.1 -0.6 0.2 0.7 0.3 0.3 -0.7
Blood Red Count 0.8 8.1 14.4 -3.0 -3.8 -3.0 -2.9 -1.2 -2.5 -2.9
Blood White Count 0.1 0.8 2.9 0.6 -0.2 1.7 0.7 -0.9 0.8 -0.0
Heel T-Score 0.3 2.1 6.6 1.6 0.8 1.2 0.3 2.6 1.1 1.4
BMI 0.8 4.5 15.5 -1.7 -3.9 -0.8 -0.7 -1.8 -1.4 -2.6
Height 0.4 7.1 27.9 -2.7 1.3 -5.3 -2.1 -0.2 -2.8 -0.4
Waist Hip Ratio (WHR) 0.2 1.0 3.1 -0.3 0.5 1.8 0.5 1.7 0.2 0.4
Systolic Blood Pressure 0.3 1.4 7.8 -0.6 -0.2 -0.6 -2.8 -0.4 -0.6 0.9
Smoking Status 0.0 0.1 0.3 0.3 -0.0 0.0 0.5 0.1 0.2 -0.5
Allergy or Eczema 0.4 0.9 2.1 -1.2 -1.3 1.0 -0.1 -0.3 -0.4 -1.4
Cardiovascular Disease 0.3 0.9 1.6 -1.1 -0.6 0.2 -1.3 -1.2 -1.3 -0.3
Hypothyroidism (self reported) 1.5 3.4 9.0 1.1 1.3 3.0 2.9 -1.2 1.4 0.6
Respiratory disease 0.6 1.3 2.4 -1.4 -1.5 -0.4 -1.0 0.4 -1.4 -1.3
Type 2 Diabetes (T2D) (2018) 0.7 1.3 4.1 -0.5 -1.9 0.1 -1.0 -0.3 -0.3 -2.0
Lung FEV1/FVC ratio 0.2 0.8 1.9 1.1 0.6 1.4 0.3 -1.1 1.1 -0.1
Lung FVC 0.6 3.3 8.1 1.1 2.8 0.7 1.4 1.8 1.4 2.5
Neuroticism 0.3 0.6 1.6 -1.0 -0.0 -0.5 -0.6 -0.1 -1.1 -1.3
Chronotype (morning person) 2.6 6.0 14.1 -2.1 -3.8 -1.4 -2.6 -1.0 -2.6 -2.7
Hair Pigment 0.2 4.7 11.1 0.9 2.2 -2.1 -2.5 2.2 0.7 3.3
Tanning 0.1 1.2 2.8 -1.7 -1.0 -0.3 -1.1 -0.4 -1.5 -1.0
Hand grip strength (left) 0.3 0.8 1.9 -0.3 -0.3 -0.9 -0.8 1.4 -0.1 1.3
Number of treatments/medications taken 2.7 4.8 10.6 -1.7 -3.3 1.0 -0.3 -2.2 -1.8 -3.2
Average weekly spirits intake 0.5 0.6 1.6 0.1 -1.2 -0.6 -1.2 0.0 -0.3 -0.6
Sensitivity / hurt feelings 0.5 0.8 2.6 -0.6 -1.1 -0.3 -0.0 -0.9 -0.5 -1.6
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.7 -0.8 0.5 1.3 1.3 -0.3 -0.8 -0.1
Hearing difficulty/problems: Yes 0.4 0.6 3.1 0.4 -0.3 1.8 0.3 -0.3 0.5 -0.7
Relative age of first facial hair 0.2 0.4 2.1 -0.3 -1.4 -0.7 -0.3 0.1 -0.1 -0.4
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 2.7 -1.2 -1.6 0.4 -1.3 0.4 -0.6 -1.2
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.2 -0.0 0.4 0.4 -0.3 -0.3 -0.0 0.2
Ever had hysterectomy (womb removed) 0.5 0.6 2.1 -0.3 1.5 0.6 0.8 -0.7 -0.5 -0.0
Systolic blood pressure, automated reading 0.5 1.6 6.3 -0.7 -0.8 -1.1 -2.5 0.7 -1.2 0.5
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.6 -0.5 -1.1 0.0 0.9 0.1 -0.6 -1.3
Angina 0.3 0.5 1.7 0.5 -0.3 1.0 0.0 1.3 0.3 0.2
Medication for hormone replacement therapy 0.6 0.6 2.2 -0.5 -0.2 -1.5 -0.5 -0.6 -1.0 -0.6
Vitamin and mineral supplements 0.3 0.4 0.9 0.8 0.2 -0.8 0.3 1.0 0.9 0.0
Supplements: Zinc 0.6 0.6 1.9 0.2 1.0 1.1 1.4 -0.2 0.1 0.3
Medication: Co-codamol 0.7 0.8 2.1 0.1 0.8 0.6 0.4 1.4 0.1 1.5
Medication: Metformin 0.3 0.5 1.0 1.0 -0.9 -0.5 -0.5 0.6 0.9 -0.2
Diabetes (father) 0.3 0.4 1.0 -1.0 -0.3 -0.6 -0.5 0.0 -0.7 -0.5
Diabetes (mother) 1.0 1.2 2.8 1.1 0.0 1.3 1.7 -1.4 1.0 -0.2
Severe depression (siblings) 0.5 0.6 1.2 1.1 -1.0 0.9 -0.5 0.3 0.7 -0.3
Pack years adult smoking proportion 0.3 0.4 1.8 0.4 -0.2 -0.4 -0.7 -0.4 0.2 1.4
Impedance of leg (right) 0.2 1.1 3.3 1.1 1.8 0.8 1.2 0.2 0.8 0.7
Leg fat-free mass (left) 0.5 2.7 7.7 -1.6 -1.5 -2.8 -1.3 -1.3 -1.3 -1.2
Trunk fat percentage 0.7 2.8 6.4 -1.6 -2.5 -0.5 -0.8 -1.0 -1.9 -2.2
Hand grip strength (right) 0.3 0.9 2.9 -0.5 0.6 -0.6 -0.5 1.3 -0.2 1.7
Townsend deprivation index at recruitment 0.6 0.8 2.4 0.9 -1.4 0.4 0.2 0.5 -0.1 -1.6
Current tobacco smoking 0.3 0.5 1.0 0.8 -0.5 -0.9 0.2 1.0 0.5 0.4
Average weekly fortified wine intake 0.4 0.5 1.0 -0.1 -0.8 -1.0 -0.7 -0.7 0.1 -0.6
Maternal smoking around birth 3.4 4.9 9.1 -3.0 -1.9 -2.4 -2.5 -0.6 -2.3 -1.9
Fed-up feelings 0.3 0.5 1.2 -0.6 0.7 -0.2 1.1 -0.5 -1.0 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.7 6.2 0.1 1.3 1.7 2.5 0.5 -0.3 0.6
Relative age voice broke 0.2 0.3 1.2 0.1 -1.1 -0.1 -0.7 0.1 0.0 -0.5
Taking other prescription medications 1.3 2.0 6.0 -0.7 -2.5 1.1 -0.7 -0.8 -1.2 -2.0
Age when periods started (menarche) 0.1 0.2 0.7 -0.9 0.7 -0.2 0.2 -0.2 -0.5 -0.2
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.2 -1.1 0.5 -0.6 0.0 0.3 -1.1 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 2.5 1.5 1.3 0.7 0.6 1.2 1.6 0.9
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.7 0.2 0.8 -0.9 -0.9 0.2 -0.3 1.3
Qualifications: CSEs or equivalent 0.2 0.2 0.4 0.4 -0.5 0.6 0.1 -0.6 -0.1 -0.6
Serious illness, injury or assault to yourself 0.9 1.0 2.1 -0.7 -1.4 -0.8 -1.4 -1.3 -0.6 -0.3
High blood pressure 0.6 1.8 3.3 -1.5 -1.7 -0.6 -1.8 -0.8 -1.4 -1.0
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.8 -0.9 -1.4 0.0 -0.5 -0.8 -0.2 -0.8
Multivitamins +/- minerals 0.3 0.4 1.1 -0.5 0.5 0.0 -0.7 -1.0 -0.7 0.7
Stomach or abdominal pain in last month 0.8 1.0 2.6 -1.6 -0.7 -0.2 -0.4 0.3 -1.6 -1.1
Supplements: Glucosamine 0.7 0.9 1.3 -1.0 -0.9 -0.9 -1.1 0.4 -0.8 -1.1
Diverticular disease/diverticulitis (self-reported) 1.0 1.1 2.7 -0.5 -1.5 -1.5 -1.7 0.1 -0.3 -0.7
Medication: Atenolol 0.6 0.8 3.3 0.6 0.1 1.8 0.1 1.1 0.7 0.5
Medication: Levothyroxine sodium 0.7 1.2 4.5 -0.2 0.5 1.7 2.1 -0.9 -0.0 -0.2
Sitting height 0.8 5.5 13.8 -2.9 0.9 -3.7 -2.0 0.8 -3.0 -1.4
Chronic bronchitis/emphysema (father) 0.3 0.3 0.9 -0.1 -1.0 -0.6 -0.7 0.3 -0.3 0.5
High blood pressure (mother) 0.7 1.0 1.9 1.4 1.2 0.2 0.3 -1.4 1.2 0.3
Body mass index (BMI) 0.5 2.2 9.1 -1.0 -3.0 -0.2 -0.6 -1.3 -0.8 -1.7
Impedance of leg (left) 0.2 0.9 3.6 0.6 1.9 0.4 1.0 0.9 0.1 0.8
Leg predicted mass (left) 0.5 2.8 8.0 -1.7 -1.5 -2.8 -1.4 -1.2 -1.4 -1.1
Trunk fat mass 0.9 3.8 6.2 -2.2 -2.5 -1.4 -1.1 -1.3 -2.4 -2.3
Waist circumference 0.6 2.2 6.8 -1.5 -2.6 -0.6 -1.0 -0.7 -1.3 -1.6
Number of incorrect matches in round 0.4 0.6 3.6 -0.6 -0.4 -0.2 0.3 -1.9 -0.2 -0.0
Past tobacco smoking 0.5 1.0 2.8 0.8 0.7 0.2 -0.3 1.7 1.0 1.4
Alcohol usually taken with meals 0.6 1.0 2.4 -0.4 -1.5 0.9 -1.1 0.6 -1.3 -0.6
Nervous feelings 0.2 0.4 1.0 -1.0 0.3 -0.4 -0.3 -0.5 -1.0 -0.1
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.2 6.3 -1.0 1.2 2.5 1.7 -1.2 -1.2 -0.8
Hearing difficulty/problems with background noise 0.6 1.0 4.6 0.8 -0.2 2.1 0.4 1.0 0.4 -0.5
Hair/balding pattern: Pattern 2 0.3 0.4 0.9 0.6 -0.3 -0.4 -0.7 -0.6 0.9 0.7
Had menopause 0.3 0.4 1.8 0.4 -0.4 -1.3 -0.0 -0.5 0.5 0.4
Had other major operations 0.3 0.4 1.3 0.1 0.3 0.0 1.1 -0.7 1.0 0.1
Forced vital capacity (FVC) 0.3 1.0 2.8 -0.6 1.7 -1.6 0.4 -0.4 0.7 0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 4.1 1.0 1.3 0.5 0.2 2.0 0.7 0.8
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 0.9 0.6 -0.5 0.6 0.7 0.9 0.7 -0.5
Qualifications: None of the above 0.7 1.4 3.0 -0.9 -1.1 -0.4 -1.0 -1.7 -1.6 -1.2
Financial difficulties in last 2 years 0.7 1.0 3.8 -1.4 0.0 0.0 -0.5 0.8 -1.9 -0.5
Mouth/teeth dental problems 0.5 0.8 1.4 0.7 0.3 -1.1 0.3 1.2 0.7 1.2
Heart attack 0.9 1.1 2.3 -1.2 -0.9 1.2 -1.3 -0.1 -1.5 -0.5
Allergy 1.0 2.3 3.7 1.8 1.8 -0.4 1.1 1.0 1.8 1.9
Pain all over the body in last month 0.7 0.7 2.0 -0.5 -1.1 -0.5 -1.4 0.2 -0.6 -0.9
Diabetes (self-reported) 1.8 2.7 8.5 -1.4 -2.3 -0.3 -1.3 -0.7 -0.9 -2.9
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.4 0.8 -0.3 1.2 0.2 -0.8 0.8 -0.1
Medication: Ramipril 0.4 0.5 1.5 0.6 -0.9 1.2 -0.7 -0.0 0.7 0.4
Medication: Simvastatin 0.7 1.1 3.0 -0.9 -1.2 0.5 -0.8 -1.0 -0.4 -1.7
Fluid intelligence score 0.5 1.1 3.0 -0.1 1.6 0.5 -0.2 1.2 0.3 1.7
Illnesses of siblings 1.0 1.3 4.0 0.2 2.0 0.9 0.9 -0.3 0.5 1.8
Neuroticism score 0.5 1.1 2.3 -1.5 0.2 -0.2 0.4 -0.9 -1.5 -1.4
Weight 0.6 3.1 5.3 -2.0 -2.0 -2.3 -1.1 -1.2 -1.8 -1.6
Impedance of arm (right) 0.0 0.2 0.7 0.2 0.8 0.6 0.5 0.2 -0.0 -0.5
Arm fat percentage (right) 0.8 3.1 9.9 -1.2 -3.1 -0.1 -0.2 -1.5 -1.1 -2.6
Trunk fat-free mass 0.9 5.0 17.0 -2.7 -0.3 -4.1 -1.7 -1.3 -2.3 -0.7
Hip circumference 0.5 2.0 4.2 -1.2 -2.1 -1.3 -0.5 -1.5 -1.1 -1.6
Time employed in main current job 0.5 0.6 2.4 0.0 0.4 -0.3 0.5 1.0 0.4 1.6
Alcohol intake versus 10 years previously 1.3 2.0 4.2 -0.8 -2.1 -1.5 -0.8 0.9 -1.5 -1.8
Father’s age at death 1.4 1.9 4.8 -1.6 -2.2 -1.1 -0.7 -0.1 -0.9 -1.9
Worrier / anxious feelings 0.2 0.4 1.2 -0.8 0.8 0.1 -0.0 0.3 -1.1 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.8 -0.4 -0.3 1.2 1.3 0.0 -0.7 -0.3
Falls in the last year 0.3 0.4 2.1 -0.6 0.4 -0.3 -0.1 -1.4 -0.4 -0.4
Hair/balding pattern: Pattern 3 0.8 1.2 4.0 -1.4 -0.5 -0.2 0.9 -0.2 -1.2 -2.0
Number of live births 1.3 1.9 3.8 1.5 0.6 1.2 -0.4 1.6 1.6 1.9
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 3.9 0.0 2.0 -0.9 0.6 -0.2 1.0 1.1
Pulse rate 1.6 2.7 6.7 -2.3 -0.7 -1.5 -1.8 0.1 -2.6 -0.6
Happiness 1.6 2.0 5.1 -1.5 0.1 -1.8 -1.5 2.3 -1.0 0.2
Noisy workplace 0.3 0.4 0.7 -0.0 -0.8 -0.0 -0.7 -0.3 -0.8 -0.8
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.0 -0.1 1.0 0.5 1.0 -0.1 0.6 -0.0
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.4 4.3 -0.9 -0.8 0.4 0.3 -2.1 -0.7 -1.8
Mouth/teeth dental problems: Dentures 0.1 0.2 0.6 0.4 0.3 0.8 0.4 0.1 -0.1 -0.5
Asthma 1.5 2.9 5.2 -1.9 -2.0 -0.6 -1.4 -1.1 -1.9 -2.3
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.7 7.2 -1.2 -2.1 -0.8 -1.6 -0.8 -1.5 -2.7
Medication: Cholesterol lowering 0.8 1.3 2.5 -1.2 -1.6 -0.1 -1.2 -0.8 -0.8 -1.6
Depression (self-reported) 1.6 1.9 4.8 -0.7 -0.5 2.0 1.2 -1.4 -0.4 -2.2
Medication: Lansoprazole 1.1 1.2 4.2 -1.7 -0.4 -0.4 -0.6 0.1 -2.1 -0.8
Prospective memory result 0.2 0.3 1.1 0.4 -0.2 -0.1 -0.0 -0.7 0.1 -1.0
Lung cancer (father) 2.8 3.3 5.9 1.9 1.5 1.6 2.4 -1.7 2.2 1.1
Illnesses of mother 1.4 1.7 9.0 -0.8 -0.4 -0.4 -1.0 3.0 -1.0 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 4.0 -0.4 2.0 -1.1 0.4 -1.0 0.4 0.7
Pulse wave Arterial Stiffness index 0.6 0.7 2.3 -0.4 0.0 -0.5 -1.2 1.5 0.0 0.7
Impedance of arm (left) 0.1 0.4 0.7 0.6 0.7 0.8 0.7 0.3 0.4 -0.7
Arm fat mass (right) 0.8 3.2 7.7 -1.7 -2.8 -1.1 -0.5 -1.6 -1.6 -2.3
Trunk predicted mass 0.9 4.9 17.2 -2.6 -0.3 -4.1 -1.8 -1.2 -2.3 -0.6
Standing height 0.6 6.1 24.9 -2.5 2.1 -5.0 -1.2 -0.3 -2.5 0.2
Length of working week for main job 0.3 0.4 0.9 0.3 -0.8 -1.0 -0.9 0.4 0.0 -0.2
Exposure to tobacco smoke at home 0.4 0.4 1.2 0.2 0.0 -0.8 1.0 -1.1 0.2 -0.2
Breastfed as a baby 0.4 0.5 1.5 -0.8 0.4 1.2 0.7 -0.2 -0.9 0.1
Tense / ‘highly strung’ 1.0 1.7 4.0 -1.9 -0.9 -0.4 -0.9 0.9 -2.0 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 2.1 -0.7 -1.0 1.2 -0.0 1.0 -0.6 -1.4
Hair/balding pattern: Pattern 4 0.4 1.0 2.7 1.7 1.0 0.5 0.6 0.5 1.5 0.1
Birth weight of first child 1.1 2.0 3.9 -2.0 1.1 -2.0 -0.6 0.1 -1.9 -0.7
Peak expiratory flow (PEF) 0.5 1.2 2.8 1.0 1.7 0.7 0.9 -0.6 1.6 0.6
Pulse wave reflection index 0.8 0.9 2.2 0.3 0.6 1.4 0.4 1.5 1.1 0.6
Ever highly irritable/argumentative for 2 days 1.4 1.7 2.9 -1.4 -1.2 -1.1 -0.3 1.1 -1.6 -1.7
Loud music exposure frequency 0.4 0.4 1.4 0.8 -0.0 1.2 -0.2 0.1 0.4 0.7
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 2.3 0.6 1.5 1.0 0.1 0.5 1.0 1.3
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.3 -0.2 1.0 0.7 0.6 -1.1 -0.2 0.6
Blood clot in the leg (DVT) 0.3 0.4 1.4 -0.6 0.9 -0.2 0.0 -0.2 -1.2 0.4
Medication: Paracetamol 1.2 2.0 7.6 -0.3 -2.2 0.0 -0.1 -1.0 -0.6 -2.8
Headache pain in last month 0.3 0.6 2.2 -0.2 -1.2 0.0 0.4 0.0 -0.4 -1.5
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 1.7 1.3 1.1 -0.5 0.9 1.3 1.0 0.9
Glaucoma (self-reported) 0.8 0.9 3.8 0.4 -0.0 1.9 0.2 -1.3 0.1 -0.9
Gout (self-reported) 0.7 1.0 2.5 1.4 -1.5 0.3 -0.4 0.4 1.6 -0.1
Hypothyroidism/myxoedema (self-reported) 1.2 2.4 7.0 0.9 0.6 2.6 2.6 -1.1 1.0 -0.0
Medication: Amlodipine 0.5 0.8 2.6 -1.0 -0.0 0.1 -1.6 -0.1 -0.8 1.1
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.4 -0.7 -1.2 -0.5 -0.9 -0.8 -0.6 -0.6
Birth weight 0.4 0.8 2.0 -0.8 1.4 -0.5 1.2 0.7 -0.7 -0.4
Chronic bronchitis/emphysema (mother) 0.7 0.8 3.9 -0.6 -1.0 -0.2 -0.5 -2.0 0.1 -0.1
High blood pressure (siblings) 0.4 0.6 1.3 1.1 -1.1 0.4 -0.2 0.1 0.8 -0.8
Forced vital capacity (FVC), Best measure 0.3 1.1 3.9 -0.5 2.0 -1.4 0.2 -0.1 0.2 1.1
Body fat percentage 0.7 2.6 7.8 -1.3 -2.8 -0.1 -0.4 -1.2 -1.5 -2.2
Leg fat percentage (right) 0.4 1.6 6.5 -0.2 -2.5 0.2 0.4 -1.3 -0.1 -1.6
Arm fat-free mass (right) 0.6 2.9 9.7 -1.9 -0.6 -3.1 -1.3 -0.8 -1.9 -0.6
Exposure to tobacco smoke outside home 0.4 0.5 2.1 0.4 1.5 -0.3 0.8 -0.4 0.0 0.8
Comparative body size at age 10 0.5 1.4 3.3 1.1 0.8 0.4 1.5 -1.8 1.4 0.6
Number of full brothers 0.5 0.7 1.6 -0.5 -1.3 -0.4 -0.6 0.5 -0.9 -1.1
Worry too long after embarrassment 0.8 1.3 3.7 -1.0 -0.6 -0.7 -0.5 -1.9 -0.3 -1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.2 -0.4 -0.4 0.5 0.8 0.3 -0.7 -1.1
Wheeze or whistling in the chest in last year 0.9 1.6 3.5 -1.8 -0.6 0.4 0.6 -1.2 -1.5 -1.9
Number of children fathered 0.5 0.6 1.2 0.5 -0.5 0.8 0.7 -1.0 0.6 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 6.7 -1.2 -0.6 -2.0 -2.6 0.1 -1.3 0.6
Age at first live birth 0.4 0.8 1.5 -0.7 -1.1 -0.5 -1.2 0.9 -0.6 -1.0
Pulse wave peak to peak time 0.4 0.5 1.9 0.1 0.1 0.0 0.9 -1.4 -0.2 -0.6
Health satisfaction 0.2 0.3 0.6 -0.8 -0.2 -0.3 0.1 0.8 -0.7 -0.6
Shortness of breath walking on level ground 0.7 0.8 2.0 -1.0 -1.4 0.1 -0.0 0.3 -0.8 -1.4
Qualifications: College or University degree 0.1 0.4 0.9 -0.9 -0.6 0.1 -0.2 0.9 -1.0 -0.4
Eye problems/disorders: None of the above 0.6 0.7 2.4 0.2 0.9 -0.3 0.5 0.5 0.9 1.6
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.0 -0.4 1.4 0.2 -0.5 -1.3 -1.4 0.4
Emphysema/chronic bronchitis 1.2 1.3 4.9 -1.0 -0.6 2.2 0.4 0.6 -1.3 -0.8
Medication for pain relief, constipation, heartburn 2.0 3.3 12.3 0.6 2.7 -0.3 0.6 1.6 0.8 3.5
Neck or shoulder pain in last month 0.7 1.0 2.1 -0.2 -1.1 -1.3 -0.9 -0.7 -0.5 -1.5
Medication: Blood pressure 0.7 1.2 1.9 -1.2 -1.2 1.3 -1.2 -1.4 -0.8 -0.5
Angina (self-reported) 0.3 0.4 1.5 0.4 -0.8 0.7 -0.3 1.2 0.3 -0.1
Migraine (self-reported) 0.2 0.2 0.7 0.8 -0.4 0.2 0.5 0.3 0.6 0.1
Medication: Ibuprofen 1.2 1.5 5.2 -0.6 -1.7 -0.2 -0.9 -0.7 -0.6 -2.3
Medication: Allopurinol 1.1 1.5 5.5 1.8 -0.4 0.4 -0.1 -0.3 2.4 1.0
Medication: Omeprazole 1.2 1.4 3.7 -0.2 -1.9 -1.0 -1.0 -0.2 -1.1 -1.8
Medication: Seretide 50 evohaler 0.7 0.8 3.6 -0.5 -1.1 1.9 0.3 -0.1 -0.5 -0.7
Mean time to correctly identify matches 1.7 3.2 6.5 -2.3 -1.6 1.0 -0.0 -2.0 -2.5 -1.9
Heart disease (mother) 0.7 0.8 4.6 -0.2 0.5 0.7 0.7 -2.1 0.3 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 1.8 -1.2 -0.9 -0.3 -1.2 -0.5 -1.3 -1.1
Whole body fat mass 0.8 3.3 7.0 -1.9 -2.6 -1.2 -0.7 -1.5 -2.0 -2.2
Leg fat mass (right) 0.7 2.8 8.5 -1.2 -2.9 -0.8 -0.4 -1.7 -1.1 -2.1
Arm predicted mass (right) 0.7 3.3 11.1 -2.2 -0.5 -3.3 -1.4 -0.7 -2.1 -0.5
Pulse rate, automated reading 2.4 7.7 15.5 -3.9 -1.4 -3.0 -3.0 -0.7 -3.9 -1.4
Alcohol intake frequency. 0.6 1.3 5.3 0.1 -1.8 -2.3 0.0 -0.2 -0.1 -0.7
Comparative height size at age 10 0.1 0.8 2.8 -0.5 0.7 -1.7 -0.2 -0.7 -1.0 -0.8
Number of full sisters 0.3 0.4 0.8 0.8 -0.9 -0.6 -0.2 0.6 0.6 0.0
Suffer from ‘nerves’ 0.3 0.5 1.0 -0.5 0.6 0.8 0.9 0.4 -1.0 -0.7
Overall health rating 0.2 0.4 1.2 -0.2 -0.5 0.9 1.1 0.0 -0.6 0.1
Chest pain or discomfort 0.5 0.7 1.9 -1.2 -0.2 -0.1 0.7 -1.4 -1.1 -0.3
Had major operations 0.8 1.0 3.0 -1.2 -0.5 -0.5 -1.7 0.2 -1.1 -0.8
Age at last live birth 0.6 0.9 3.1 -0.8 -1.2 0.2 -1.8 0.6 -0.5 -0.8
Family relationship satisfaction 0.5 0.6 1.5 -0.9 -0.4 -1.2 -0.9 0.7 -0.7 -0.2
Leg pain on walking 0.4 0.5 1.5 -0.5 -0.9 -0.8 0.2 -1.2 -0.2 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.8 -0.0 0.6 1.3 1.0 -0.4 0.3 0.2
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.3 0.4 0.1 -0.5 0.3 0.3 0.7 1.1
Illness, injury, bereavement, stress in last 2 years 3.0 3.6 8.5 2.3 1.6 1.7 2.1 -0.1 2.9 1.3
Medication: Aspirin 0.6 0.7 2.7 -0.3 -1.6 0.2 -0.3 -0.9 -0.0 -1.2
Supplements: Vitamin C 0.8 0.9 3.2 0.5 0.0 1.8 -0.2 1.1 0.1 1.2
Knee pain experienced in last month 0.6 1.0 3.3 -0.7 -1.8 -0.5 -1.0 0.5 -0.9 -0.9
Hypertension (Self-reported) 0.4 1.1 2.8 -1.1 -1.3 0.1 -1.7 -0.7 -1.2 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 4.2 -1.5 -0.4 -0.4 -1.3 0.3 -2.0 -0.6
Illnesses of father: Heart disease 1.1 1.5 3.3 -1.0 -1.1 -1.7 -1.8 -0.5 -1.2 -0.8
Illnesses of siblings: Diabetes 0.3 0.3 0.7 -0.5 -0.0 -0.7 -0.1 0.4 -0.9 -0.9
Smoking status: Previous 1.0 1.4 3.7 -1.1 -0.8 -0.4 0.2 -1.9 -1.3 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.9 -0.7 0.8 -0.4 1.0 -0.7 -0.3 -0.7
Whole body fat-free mass 0.7 3.8 13.0 -2.3 -0.7 -3.6 -1.5 -1.1 -2.0 -0.7
Leg fat-free mass (right) 0.6 3.0 8.8 -1.9 -1.4 -3.0 -1.5 -0.7 -1.7 -1.0
Arm fat percentage (left) 0.8 3.2 11.1 -1.1 -3.3 0.1 -0.3 -1.3 -1.0 -2.8
Average weekly red wine intake 0.2 0.3 0.8 -0.1 0.5 -0.6 0.7 -0.2 -0.9 0.1
Handedness (chirality/laterality): Left-handed 1.4 1.7 4.3 -1.6 -0.8 -2.1 -1.2 0.6 -1.6 -0.5
Mood swings 0.7 1.2 4.7 -0.5 -1.2 -1.0 -0.4 -0.7 -0.5 -2.2
Loneliness, isolation 0.7 1.0 2.6 -1.6 -0.5 -0.5 -0.1 0.2 -1.6 -1.1
Long-standing illness, disability or infirmity 2.4 3.7 11.4 -0.7 -3.4 0.3 -0.5 -2.2 -0.3 -2.9
Ever had bowel cancer screening 2.3 2.7 5.8 -0.9 -2.4 -0.2 -1.8 0.5 -1.8 -2.3
Diabetes diagnosed by doctor 1.2 1.9 6.2 -0.6 -2.3 -0.2 -1.1 -0.8 -0.2 -2.5
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 2.1 0.9 -1.5 0.5 -1.2 0.2 0.7 -0.4
Friendships satisfaction 0.9 1.1 4.5 -0.1 1.4 0.6 0.4 2.1 -0.1 1.0
Qualifications: nursing, teaching 1.2 1.9 5.2 1.9 0.8 1.3 0.9 0.4 2.3 0.9
Commuting to job workplace: Walk 0.8 0.8 2.3 1.5 0.9 0.3 0.5 0.3 1.0 1.1
Eye problems/disorders: Cataract 0.6 0.7 1.3 0.8 -0.3 0.8 1.2 -0.9 0.4 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.5 -0.7 -1.3 -0.1 -0.3 -0.0 -0.3 -1.6
Medication for cholesterol 1.0 1.6 3.0 0.5 1.7 0.8 1.4 1.4 1.0 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.4 1.5 -0.2 0.7 0.4 0.3 1.6 0.4
Back pain experienced in last month 0.4 0.6 1.4 -0.9 -0.0 -0.5 0.4 -1.2 -0.8 -1.0
Mineral and other dietary supplements 1.9 2.5 6.9 2.6 1.5 1.0 0.8 1.0 2.0 1.4
Breast cancer (self-reported) 0.2 0.3 0.4 0.5 0.7 0.6 -0.2 0.2 0.6 0.6
Asthma (self-reported) 1.5 2.9 4.6 -2.1 -1.9 -0.7 -1.5 -1.1 -2.0 -2.1
Osteoporosis (self-reported) 0.6 0.8 2.7 -1.6 0.3 -0.5 -1.0 -0.1 -1.1 -0.0
Osteoarthritis (self-reported) 0.7 0.9 2.3 -1.3 -1.5 -0.1 -1.1 0.3 -1.0 -0.6
Medication: Aspirin 0.7 0.9 3.7 -0.4 -1.9 -0.2 -0.3 -0.5 -0.2 -1.5
Medication: Gliclazide 0.2 0.2 0.6 -0.5 -0.2 -0.1 -0.8 0.4 -0.4 -0.1
Illnesses of father: None of the above (group 1) 3.9 4.8 9.9 2.5 1.1 2.8 3.2 -0.3 2.9 -0.0
Smoking status: Current 0.3 0.4 1.1 0.9 -0.3 -0.7 0.2 1.0 0.6 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.8 4.2 1.6 1.9 0.4 0.9 -0.0 2.0 1.3
Whole body water mass 0.7 4.0 13.4 -2.3 -0.7 -3.7 -1.6 -1.1 -2.1 -0.8
Leg predicted mass (right) 0.6 3.0 9.2 -1.9 -1.4 -3.0 -1.4 -0.7 -1.7 -1.0
Arm fat mass (left) 0.8 3.2 8.0 -1.6 -2.8 -1.2 -0.7 -1.5 -1.4 -2.3
Number of self-reported non-cancer illnesses 1.9 3.4 7.5 -1.6 -2.7 0.4 -1.7 -0.5 -1.8 -2.6
Average weekly champagne plus white wine intake 0.5 0.7 1.5 -1.2 -1.2 1.1 -0.3 -0.3 -0.8 -0.6
Miserableness 1.0 1.8 4.4 -2.1 0.9 -0.0 1.1 -0.1 -1.7 -1.7
Guilty feelings 0.6 0.9 2.3 -0.9 -1.1 -0.2 0.0 -1.1 -0.9 -1.5
Wears glasses or contact lenses 1.4 1.6 4.8 0.1 1.5 1.6 2.2 -0.1 0.2 1.1
Ever taken oral contraceptive pill 0.3 0.4 1.3 -0.2 0.5 1.1 0.8 0.3 0.4 -0.3
Hearing aid user 1.0 1.1 2.6 0.8 0.2 1.6 0.5 1.4 0.8 1.2
Mother’s age at death 0.5 0.6 2.6 -0.1 0.9 -0.5 -0.2 -1.6 -0.2 0.7
Financial situation satisfaction 0.5 0.7 1.9 -1.1 0.0 -1.4 -0.6 0.2 -1.1 -0.3
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.6 -0.3 1.2 0.9 1.6 -0.8 -0.2 -0.1
Commuting to job workplace: Public transport 0.4 0.5 1.3 -0.5 1.1 0.4 -0.2 0.9 -0.7 0.8
Eye problems/disorders: Glaucoma 0.8 0.9 2.5 0.8 0.2 1.6 0.2 -1.6 0.2 -0.9
Medication: Blood pressure 0.4 0.8 3.3 0.2 -1.8 -0.1 -1.5 -0.5 0.0 -0.5
Pain type(s) experienced in last month: Hip pain 0.5 0.7 2.2 -1.2 -0.8 -0.2 0.1 0.1 -0.7 -1.5
Supplements: Fish oil (including cod liver oil) 0.7 0.9 3.5 -1.9 -0.6 -0.5 -0.5 -0.9 -1.1 -0.1
High cholesterol (Self-reported) 0.4 0.7 1.2 -0.7 -0.8 1.1 -0.7 -0.2 -0.9 -1.0
Medication: Bendroflumethiazide 0.5 0.7 2.0 -0.7 -0.8 -0.8 -1.4 -0.3 -0.9 -0.6
Medication: Paracetamol 1.2 1.8 5.8 0.1 -2.3 -0.1 -0.3 -1.1 0.1 -2.4
Medication: Lisinopril 0.8 1.0 2.0 -0.8 -1.4 0.6 -1.0 -1.2 0.1 -1.3
Medication: Atorvastatin 0.4 0.5 0.9 0.4 0.8 0.9 1.0 -0.1 -0.0 0.9
Illnesses of father: High blood pressure 1.1 1.4 4.8 -0.9 -1.0 -0.8 -2.2 0.1 -1.2 -1.1
Alcohol drinker status: Never 1.1 1.3 4.9 0.6 0.8 -2.2 -0.9 0.6 -0.2 1.3
Ever smoked 0.2 0.4 1.7 -0.1 -0.8 -0.5 0.2 -1.3 -0.1 -0.5
Basal metabolic rate 0.7 3.9 11.8 -2.3 -1.1 -3.4 -1.4 -1.2 -2.0 -1.1
Leg fat percentage (left) 0.4 1.4 6.4 -0.3 -2.5 0.0 0.2 -0.9 -0.5 -1.4
Arm fat-free mass (left) 0.5 2.6 10.2 -1.7 -0.3 -3.2 -1.0 -1.1 -1.6 -0.2
Number of operations (self-reported) 1.8 2.6 4.4 -2.1 -1.7 -0.7 -1.9 0.6 -1.6 -2.0
Average weekly beer plus cider intake 0.4 0.6 2.8 0.4 0.5 -1.7 -0.5 -0.3 0.3 0.5
Irritability 1.3 2.1 6.7 -2.3 0.0 -0.4 -0.3 -0.1 -2.6 -1.7
Risk taking 0.6 0.9 5.1 -0.4 1.0 0.1 0.5 -2.3 -0.0 0.1
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.4 -0.6 1.5 0.5 0.4 -1.4 -0.6 -0.7
Fractured/broken bones in last 5 years 0.3 0.4 1.4 -0.2 0.1 -0.3 1.0 -1.2 -0.2 -0.2
Age started oral contraceptive pill 1.1 1.4 2.6 -1.6 -0.0 -1.3 -1.5 -0.3 -1.6 -0.6
Diastolic blood pressure, automated reading 0.8 2.4 6.0 -0.4 0.8 -1.1 -1.8 2.4 -1.1 2.2
Ever depressed for a whole week 0.4 0.5 1.5 -0.7 0.6 -0.9 0.3 1.2 -0.3 0.1
Unable to work because of sickness or disability 0.3 0.5 1.9 0.1 0.6 0.2 1.4 -0.1 -0.3 0.8
Commuting to job workplace: Cycle 0.4 0.5 1.5 -0.1 0.5 0.6 -0.4 -0.9 -0.4 -1.2
Myopia 0.5 0.8 2.3 0.5 -1.5 -0.4 -0.0 0.2 0.7 -1.5
Vascular/heart problems diagnosed by doctor 0.6 1.7 2.5 1.5 1.5 0.2 1.6 1.1 1.6 1.0
Cholesterol lowering medication 0.5 0.8 2.2 -0.2 -0.9 1.5 0.4 -0.7 -0.2 -1.3
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 2.4 -0.9 -1.4 -1.2 -0.8 -0.1 -1.6 -1.4
Pain experienced in last month 0.9 1.4 4.4 1.1 1.2 -0.2 0.1 0.1 1.8 2.1
Supplements: Calcium 0.2 0.3 0.5 -0.7 0.1 -0.2 -0.7 0.4 -0.7 -0.5
Basal cell carcinoma (self-reported) 1.3 1.6 4.4 1.2 1.0 0.0 -1.2 1.2 1.0 2.1
Heart attack/myocardial infarction (self-reported) 0.8 1.0 1.6 -1.0 -0.9 1.2 -1.3 -0.1 -1.3 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 2.4 -1.0 0.8 -0.3 -0.2 -0.4 -1.5 0.1
Heart disease (siblings) 0.7 0.8 2.6 -0.9 -0.6 0.2 -0.4 -0.2 -1.6 -1.4
Alcohol drinker status: Previous 1.2 1.4 4.2 -1.2 -1.2 -0.7 1.0 -0.7 -0.9 -2.0
Pack years of smoking 0.2 0.4 1.2 0.1 -0.2 -0.6 -0.9 -0.3 -0.2 1.1
Impedance of whole body 0.2 0.9 2.9 0.7 1.7 0.9 1.1 0.7 0.3 0.3
Leg fat mass (left) 0.7 2.8 8.2 -1.3 -2.9 -1.0 -0.5 -1.6 -1.4 -2.1
Arm predicted mass (left) 0.7 3.6 12.7 -2.1 -0.4 -3.6 -1.4 -1.1 -2.1 -0.5