TWAS hub - HSD17B6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.385	0.054	3.6e-14	0.225	0.142	0.218	0.236	0.234	5.4e-27	6.8e-17	4.2e-26	2.4e-28	4.7e-28
2	GTEx	Brain Cerebellum	0.314	0.098	1.3e-03	0.274	NA	0.250	NA	0.290	9.8e-09	NA	5.1e-08	NA	3.2e-09
3	GTEx	Colon Sigmoid	0.115	0.050	4.4e-03	0.080	NA	0.084	NA	0.084	8.7e-04	NA	6.9e-04	NA	6.9e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Platelet Count	12.6	145.7	420.2	3.6	2.0	20.5
Had menopause	11.0	13.8	19.4	4.1	4.4	-2.3
Medication: Aspirin	6.0	7.9	10.2	3.1	3.2	1.9
Had other major operations	5.8	7.0	8.2	2.9	2.4	2.7
Medication: Aspirin	4.9	6.5	8.9	2.9	3.0	1.5
Heart disease (siblings)	4.6	5.7	11.1	1.8	1.6	3.3
Illnesses of siblings	4.5	6.3	9.7	-2.1	-2.2	-3.1
Allergy or Eczema	4.3	11.3	18.4	-3.8	-4.3	1.0
Hayfever, allergic rhinitis or eczema	4.3	9.4	14.3	-3.6	-3.8	1.1
Tinnitus: Yes, now most or all of the time	4.0	4.7	4.9	-2.2	-2.2	2.1
Myopia	3.8	5.5	6.2	2.5	2.4	-2.2
Asthma	3.7	7.3	10.2	-3.2	-3.1	1.4
Ever used hormone-replacement therapy (HRT)	3.6	4.6	7.0	2.7	2.5	-0.4
Age at last live birth	3.5	5.0	7.5	-2.7	-2.6	0.9
Hand grip strength (right)	3.4	9.2	10.1	-2.9	-3.0	-3.2
Medication: Ventolin 100micrograms inhaler	3.4	4.4	6.1	-2.5	-2.4	1.2
Asthma (self-reported)	3.3	6.5	9.3	-3.1	-2.9	1.3
Hayfever/allergic rhinitis (self-reported)	3.2	4.3	5.2	-1.7	-2.3	2.2
Chronotype (morning person)	3.1	7.2	9.6	-2.4	-3.1	2.4
Hand grip strength (left)	3.1	8.2	10.0	-3.0	-3.2	-2.4
Whole body fat-free mass	3.1	17.5	26.2	-5.1	-5.1	-0.2
Whole body water mass	3.1	17.8	26.9	-5.2	-5.1	-0.3
Arm fat-free mass (left)	3.1	15.6	24.0	-4.9	-4.8	-0.1
Trunk predicted mass	3.0	17.1	26.4	-5.0	-5.1	-0.5
Leg predicted mass (right)	3.0	16.1	24.8	-5.0	-4.9	0.1
Bipolar Disorder (2011)	2.9	2.8	4.2	2.0	2.0	-0.6
Trunk fat-free mass	2.9	16.8	26.0	-4.9	-5.1	-0.5
Leg fat-free mass (right)	2.9	15.7	24.2	-4.9	-4.8	0.1
Rheumatoid Arthritis	2.8	3.9	4.6	-2.1	-2.1	1.6
Leg predicted mass (left)	2.8	14.8	23.3	-4.8	-4.6	-0.2
Peak expiratory flow (PEF)	2.8	6.4	8.8	-3.0	-2.6	-1.9
Basal metabolic rate	2.8	15.6	23.8	-4.9	-4.8	-0.3
Arm predicted mass (left)	2.8	14.4	22.5	-4.7	-4.5	-0.5
Waist Hip Ratio (WHR)	2.7	12.4	20.9	4.6	4.0	0.2
Leg fat-free mass (left)	2.7	14.4	22.7	-4.8	-4.5	-0.2
Pulse rate	2.7	4.6	7.8	1.8	1.7	2.8
Loud music exposure frequency	2.7	3.0	8.2	0.2	0.8	-2.9
Ovarian Cancer	2.6	3.4	6.4	1.4	1.4	2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	4.0	11.3	0.8	0.3	3.4
High blood pressure (siblings)	2.6	3.7	5.9	1.7	1.6	2.4
Major Depression (MDD)	2.5	3.1	5.0	2.1	2.2	0.1
High blood pressure (mother)	2.5	3.5	4.3	1.8	1.7	2.1
Allergy	2.5	5.8	8.5	2.9	2.9	-0.8
Arm fat-free mass (right)	2.5	12.8	19.2	-4.4	-4.4	-0.2
Arm predicted mass (right)	2.5	12.8	19.4	-4.4	-4.3	-0.0
Ever smoked	2.5	4.4	13.2	0.2	-0.1	3.6
Pain all over the body in last month	2.4	2.6	3.1	-1.7	-1.8	1.4
Impedance of whole body	2.4	12.4	21.2	4.6	3.9	-0.5
Guilty feelings	2.3	3.4	5.6	-1.7	-2.4	1.4
Alcohol drinker status: Previous	2.3	2.6	3.2	1.4	1.6	1.8
Vitamin and mineral supplements	2.2	3.0	4.8	-2.0	-2.2	0.4
Impedance of leg (right)	2.2	10.7	17.2	4.1	3.6	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	2.2	5.0	11.0	-1.2	-1.6	3.3
High blood pressure	2.2	6.2	16.2	-0.8	-1.3	4.0
Hip circumference	2.2	9.6	16.0	-4.0	-3.6	-0.2
Type 2 Diabetes (T2D) (2012)	2.1	2.4	3.2	1.4	1.4	-1.8
Cardiovascular Disease	2.1	6.8	19.3	-0.5	-1.0	4.4
Impedance of leg (left)	2.1	10.2	16.9	4.1	3.5	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.9	9.4	-1.4	-1.8	3.1
Hearing aid user	2.1	2.4	6.0	-0.7	-0.9	2.5
Diastolic blood pressure, automated reading	2.1	6.7	19.8	-0.1	-0.4	4.5
Heel T-Score	2.0	16.2	48.4	0.1	-0.4	7.0
Average weekly spirits intake	2.0	2.5	2.7	-1.6	-1.5	1.6
Frequency of depressed mood in last 2 weeks	2.0	2.8	6.8	1.1	0.6	2.6
Ever unenthusiastic/disinterested for a whole week	2.0	2.5	3.7	1.9	1.9	0.2
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	10.0	-0.1	0.1	-3.2
Osteoporosis (self-reported)	2.0	2.5	3.4	1.6	1.8	-1.2
Bipolar Disorder (2018)	1.9	3.0	3.8	1.9	2.0	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	6.3	0.8	0.6	2.5
Hypertension (Self-reported)	1.9	5.2	14.1	-0.6	-1.1	3.7
Illnesses of father: None of the above (group 1)	1.9	2.3	4.5	-1.3	-0.8	-2.1
Depressed Affect (Nagel 2018)	1.8	3.9	11.0	-0.0	-0.8	3.3
Supplements: Glucosamine	1.8	2.4	7.0	0.3	0.3	-2.6
Falls in the last year	1.8	2.5	4.2	1.7	2.0	0.7
Wheeze or whistling in the chest in last year	1.8	3.2	9.1	-0.6	-0.5	3.0
Medication: Blood pressure	1.8	3.2	9.2	-0.4	-0.5	3.0
Comparative height size at age 10	1.8	10.1	17.3	-3.5	-4.2	1.0
Ever had prostate specific antigen (PSA) test	1.8	2.0	5.7	0.1	-0.6	2.4
Vascular/heart problems diagnosed by doctor	1.8	4.9	13.7	0.6	0.9	-3.7
Respiratory disease	1.7	3.9	5.7	-2.3	-2.4	0.8
Impedance of arm (left)	1.7	7.7	13.6	3.7	3.0	-0.4
Medication: Bendroflumethiazide	1.7	2.6	4.5	-1.2	-1.3	2.1
Depression (Nagel 2018)	1.6	2.3	6.9	0.4	0.1	2.6
Age at First Birth	1.6	2.4	2.9	-1.7	-1.3	-1.6
Weight	1.6	7.8	13.0	-3.6	-3.2	-0.4
Depression (self-reported)	1.6	1.9	3.5	-1.0	-1.0	1.9
Alcohol intake frequency.	1.6	3.7	11.1	0.2	0.1	3.3
Cholesterol lowering medication	1.6	2.4	2.6	1.4	1.6	1.6
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	2.2	1.4	1.3	1.5
Impedance of arm (right)	1.5	6.9	12.0	3.5	3.0	-0.3
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	7.1	0.1	-0.1	2.7
Medication: Cholesterol lowering	1.5	2.4	5.2	0.9	1.1	2.3
Exposure to tobacco smoke at home	1.5	1.7	1.9	1.4	1.3	1.2
Headache pain in last month	1.5	2.5	3.9	2.0	1.3	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	4.4	-0.8	-0.4	-2.1
Osteoarthritis (self-reported)	1.5	1.9	5.3	0.3	0.6	-2.3
Medication: Blood pressure	1.5	2.9	8.5	-0.1	-0.1	2.9
Body Mass Index (BMI) (2010)	1.4	1.9	2.3	-1.5	-1.4	-1.2
Blood Eosinophil Count	1.4	10.7	14.7	-3.8	-3.7	-1.9
Lung FVC	1.4	7.1	13.0	2.2	1.8	-3.6
Current tobacco smoking	1.4	2.2	3.1	1.4	1.2	1.8
Multivitamins +/- minerals	1.4	1.8	2.6	1.4	1.6	0.9
Hair/balding pattern: Pattern 2	1.4	1.8	3.0	1.2	1.0	1.7
Prospective memory result	1.4	1.8	5.2	-0.3	-0.2	2.3
Pulse wave Arterial Stiffness index	1.4	1.6	2.2	1.5	1.0	1.3
Number of children fathered	1.4	1.6	4.0	-0.1	-0.9	2.0
Pulse wave peak to peak time	1.4	1.6	2.0	-1.4	-1.0	-1.4
Medication: Seretide 50 evohaler	1.4	1.6	2.0	-1.4	-1.0	-1.4
Pulse rate, automated reading	1.4	4.5	13.3	0.2	0.2	3.6
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.8	5.5	-1.5	-2.3	0.9
Medication: Lisinopril	1.4	1.8	5.1	0.5	0.2	2.3
Medication: Atorvastatin	1.4	1.7	4.9	-0.0	-0.3	2.2
Fasting Glucose	1.3	1.5	3.4	1.9	1.1	0.1
Time employed in main current job	1.3	1.5	2.5	-1.2	-0.6	-1.6
Lung cancer (father)	1.3	1.5	2.1	0.9	1.4	-1.3
Blood clot in the leg (DVT)	1.3	1.6	2.4	1.5	1.6	-0.4
Medication: Amlodipine	1.3	1.8	4.2	1.0	0.3	2.0
Knee pain experienced in last month	1.3	2.0	3.2	1.8	1.5	-0.7
Loneliness, isolation	1.3	1.8	5.4	-0.1	-0.3	2.3
Long-standing illness, disability or infirmity	1.3	1.9	5.5	-0.3	-0.4	2.4
High cholesterol (Self-reported)	1.3	2.3	6.7	0.4	0.4	2.6
Number of operations (self-reported)	1.3	1.9	5.2	0.6	0.4	2.3
Medication: Atenolol	1.2	1.5	4.5	-0.2	-0.1	2.1
Hair/balding pattern: Pattern 3	1.2	1.8	3.2	1.2	1.0	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.3	-1.2	-1.5	0.7
Mood swings	1.2	2.2	4.5	1.3	0.7	2.1
Smoking status: Current	1.2	1.9	4.2	1.0	0.7	2.0
Number of self-reported non-cancer illnesses	1.2	2.1	6.1	-0.1	-0.4	2.5
Ulcerative Colitis	1.1	1.5	2.4	1.6	1.3	-0.6
Height	1.1	22.0	38.8	-5.0	-6.2	-1.4
Medication: Metformin	1.1	1.6	2.4	1.6	1.5	0.5
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	1.4	-1.2	-1.2	-1.0
Medication: Allopurinol	1.1	1.5	2.6	1.6	1.3	0.2
Illnesses of siblings: Diabetes	1.1	1.3	2.2	1.3	1.5	0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	1.8	-1.3	-1.3	0.2
Qualifications: nursing, teaching	1.1	1.6	4.7	0.4	-0.1	2.2
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.0	1.3	1.4	-0.7
HDL Cholesterol	1.0	1.7	2.7	-1.6	-1.5	-0.2
Blood Red Count	1.0	9.8	18.3	-4.3	-3.3	-0.1
Medication for hormone replacement therapy	1.0	1.2	1.6	0.9	1.0	-1.2
Supplements: Zinc	1.0	1.1	2.0	-0.5	-1.0	1.4
Relative age voice broke	1.0	1.5	3.5	-0.6	-0.8	-1.9
Stomach or abdominal pain in last month	1.0	1.2	3.5	0.3	0.1	1.9
Father’s age at death	1.0	1.4	4.2	0.0	0.1	-2.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.9	-1.2	-1.7	0.8
Gout (self-reported)	1.0	1.4	2.2	1.5	1.3	-0.6
Birth weight	1.0	2.2	3.5	-1.4	-1.9	1.1
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.6	0.4	0.1	2.1
Medication: Gliclazide	1.0	1.1	2.9	0.5	0.4	1.7
Commuting to job workplace: Public transport	1.0	1.2	1.5	1.2	1.2	-0.9
Smoking Status	0.9	2.1	3.1	1.8	1.4	1.2
Hypothyroidism (self reported)	0.9	2.0	3.7	-0.9	-1.2	1.9
Number of treatments/medications taken	0.9	1.6	2.1	1.3	1.0	1.4
Maternal smoking around birth	0.9	1.3	3.5	-0.3	-0.6	1.9
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.0	0.1	-0.3	1.7
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	1.6	1.2	1.2	-0.2
Standing height	0.9	9.1	17.3	-3.1	-4.2	-0.8
Medication for pain relief, constipation, heartburn	0.9	1.5	2.5	-1.4	-1.6	-0.3
Heart disease (mother)	0.9	1.1	3.2	-0.1	-0.3	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.8	1.1	1.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	3.3	-1.1	-1.1	-1.8
HbA1C	0.8	0.9	1.7	0.6	0.7	-1.3
Pack years adult smoking proportion	0.8	1.3	2.0	-1.4	-0.7	-1.1
Townsend deprivation index at recruitment	0.8	1.1	3.1	0.4	-0.1	1.8
Fed-up feelings	0.8	1.5	3.8	-0.2	-0.8	2.0
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.5	-0.5	-0.2	-1.6
Supplements: Vitamin C	0.8	0.9	2.8	0.0	0.2	-1.7
Illnesses of father: Heart disease	0.8	1.1	1.2	1.0	1.1	0.9
Mineral and other dietary supplements	0.8	1.1	3.1	-0.3	-0.3	1.8
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	1.5	1.0	1.2	-0.4
Basal cell carcinoma (self-reported)	0.8	0.9	1.8	1.3	1.0	-0.2
Pack years of smoking	0.8	1.2	1.6	-1.2	-0.7	-1.3
Schizophrenia vs Biploar Disorder	0.7	1.0	1.8	-1.1	-1.3	-0.1
Alzheimer’s Disease (in father)	0.7	0.8	1.0	0.7	0.9	1.0
Hearing difficulty/problems: Yes	0.7	1.1	1.6	-1.0	-0.8	1.3
Angina	0.7	1.0	1.5	1.0	1.2	0.7
Number of incorrect matches in round	0.7	1.2	2.2	0.8	0.9	-1.5
Past tobacco smoking	0.7	1.3	3.8	-0.3	-0.0	-1.9
Hearing difficulty/problems with background noise	0.7	1.1	3.4	0.1	-0.2	1.8
Forced vital capacity (FVC)	0.7	2.6	6.9	-0.1	-1.0	-2.6
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	5.9	-0.7	-0.9	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	4.7	-0.7	-1.2	-2.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.9	-0.6	-0.8	1.7
Age at first live birth	0.7	1.3	1.9	-1.3	-1.4	0.4
Neck or shoulder pain in last month	0.7	1.0	1.2	1.1	1.1	0.8
Miserableness	0.7	1.2	3.0	0.8	0.1	1.7
Eye problems/disorders: Glaucoma	0.7	0.9	1.3	-1.1	-1.1	-0.2
Alcohol drinker status: Never	0.7	0.9	1.4	-0.8	-1.2	0.7
Neuroticism (Nagel 2018)	0.6	1.5	2.3	-0.8	-1.3	1.5
Coronary Artery Disease (CAD)	0.6	0.8	1.6	0.3	0.8	-1.3
Neuroticism (2016)	0.6	0.9	1.0	-0.9	-1.0	0.9
Triglycerides	0.6	1.1	1.7	1.3	0.5	1.1
BMI	0.6	3.4	7.7	-2.8	-1.6	0.1
Systolic Blood Pressure	0.6	3.0	4.7	1.6	1.3	2.2
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.2	0.8	0.7	-1.5
Severe depression (siblings)	0.6	0.7	1.6	-0.1	-0.7	1.3
Taking other prescription medications	0.6	0.9	1.8	-0.4	-0.8	1.3
Age when periods started (menarche)	0.6	1.3	3.7	-0.4	-0.4	-1.9
Serious illness, injury or assault to yourself	0.6	0.8	1.4	0.9	1.2	-0.1
Body mass index (BMI)	0.6	2.5	5.4	-2.3	-1.4	-0.1
Medication: Simvastatin	0.6	0.9	1.5	0.4	1.0	1.2
Worrier / anxious feelings	0.6	1.1	2.7	0.6	0.4	-1.6
Forced vital capacity (FVC), Best measure	0.6	2.3	5.1	-0.3	-1.3	-2.3
Exposure to tobacco smoke outside home	0.6	0.9	2.2	-0.4	-0.5	1.5
Comparative body size at age 10	0.6	1.6	1.9	-1.4	-1.1	1.3
Chest pain or discomfort	0.6	0.8	2.0	-0.5	-0.3	1.4
Average weekly red wine intake	0.6	0.9	1.8	-1.3	-0.9	-0.4
Medication for cholesterol	0.6	0.9	1.6	-0.8	-0.8	-1.3
Wears glasses or contact lenses	0.6	0.7	1.5	0.5	0.5	-1.2
Illnesses of father: High blood pressure	0.6	0.8	1.5	0.9	0.3	1.2
Average weekly beer plus cider intake	0.6	0.9	1.3	1.2	1.1	0.1
Unable to work because of sickness or disability	0.6	0.7	1.8	0.5	0.4	1.3
Diabetes (mother)	0.5	0.7	1.4	0.2	0.7	-1.2
Sitting height	0.5	3.6	6.3	-2.1	-2.5	-0.5
Waist circumference	0.5	1.9	3.3	-1.8	-1.5	0.6
Happiness	0.5	0.7	2.0	-0.1	-0.1	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	0.8	0.9	0.7	-0.7
Illnesses of mother	0.5	0.6	1.4	-0.6	-0.4	-1.2
Length of working week for main job	0.5	0.6	1.2	-0.3	-0.7	1.1
Breastfed as a baby	0.5	0.6	0.8	-0.6	-0.8	0.9
Angina (self-reported)	0.5	0.6	1.0	0.7	1.0	0.7
Ever had bowel cancer screening	0.5	0.5	1.2	1.1	0.6	-0.3
Arm fat mass (left)	0.5	2.1	4.1	-2.0	-1.5	-0.2
Financial situation satisfaction	0.5	0.6	1.0	0.3	0.8	-1.0
Ulcerative Colitis (UC)	0.4	0.8	1.1	0.9	1.0	-0.7
Ever had hysterectomy (womb removed)	0.4	0.5	0.7	-0.6	-0.6	0.8
Medication: Co-codamol	0.4	0.5	1.0	-1.0	-0.7	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	0.3	0.0	1.2
Medication: Ramipril	0.4	0.6	1.6	0.2	0.3	1.2
Number of live births	0.4	0.6	1.6	-0.1	-0.3	1.3
Mouth/teeth dental problems: Dentures	0.4	0.7	1.3	0.6	1.1	-0.7
Arm fat mass (right)	0.4	1.8	3.6	-1.9	-1.3	-0.4
Glaucoma (self-reported)	0.4	0.4	0.9	-0.4	-0.5	-0.9
Qualifications: College or University degree	0.4	1.4	4.0	0.3	0.3	-2.0
Medication: Omeprazole	0.4	0.5	0.9	0.7	1.0	-0.2
Leg fat mass (right)	0.4	1.4	3.0	-1.7	-1.0	-0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.4	0.1	0.2	1.2
Eye problems/disorders: Cataract	0.4	0.5	1.0	1.0	0.7	0.4
Mother’s age at death	0.4	0.5	0.8	-0.5	-0.7	-0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.4	-0.1	-0.2	-1.2
Medication: Paracetamol	0.4	0.5	0.8	0.9	0.6	0.6
Risk taking	0.4	0.6	0.9	-0.9	-0.9	0.5
Fractured/broken bones in last 5 years	0.4	0.5	1.2	0.3	0.5	1.1
Supplements: Calcium	0.4	0.5	1.4	0.1	-0.2	1.2
Leg fat mass (left)	0.4	1.6	3.3	-1.8	-1.1	-0.6
Schizophrenia (2018)	0.3	0.6	0.9	-0.9	-0.4	-1.0
Irritable Bowel Disease (IBD)	0.3	0.8	1.1	1.0	1.0	-0.6
Blood White Count	0.3	2.5	3.9	2.0	1.8	0.6
Neuroticism	0.3	0.8	1.8	-0.2	-0.7	1.3
Hair Pigment	0.3	7.6	11.0	-2.4	-2.4	3.3
Sensitivity / hurt feelings	0.3	0.5	0.6	0.8	0.6	-0.7
Relative age of first facial hair	0.3	0.6	0.8	-0.8	-0.9	-0.7
Qualifications: CSEs or equivalent	0.3	0.4	1.0	0.3	0.1	-1.0
Medication: Levothyroxine sodium	0.3	0.5	1.3	-0.4	-0.3	1.2
Chronic bronchitis/emphysema (father)	0.3	0.3	0.8	-0.2	-0.1	-0.9
Nervous feelings	0.3	0.5	1.2	-0.4	0.1	-1.1
Heart attack	0.3	0.4	0.7	0.3	0.7	0.8
Diabetes (self-reported)	0.3	0.4	0.6	0.8	0.7	0.3
Hair/balding pattern: Pattern 4	0.3	0.8	1.9	0.1	-0.6	1.4
Pulse wave reflection index	0.3	0.3	0.5	-0.3	-0.6	-0.7
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.6	0.0	-0.7	0.7
Eye problems/disorders: None of the above	0.3	0.3	0.4	0.6	0.7	-0.3
Mean time to correctly identify matches	0.3	0.6	0.9	0.9	0.8	-0.4
Whole body fat mass	0.3	1.0	2.0	-1.4	-0.8	-0.7
Family relationship satisfaction	0.3	0.3	0.5	-0.4	-0.7	0.5
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.9	0.4	0.3	-0.9
Smoking status: Previous	0.3	0.5	0.7	0.8	0.7	0.4
Irritability	0.3	0.5	0.9	0.6	0.6	-0.9
Worry (Nagel 2018)	0.2	0.4	0.6	-0.6	-0.4	-0.8
Alzheimer’s Disease (in mother)	0.2	0.3	0.3	-0.5	-0.6	-0.5
Crohns Disease (2017)	0.2	0.4	0.6	0.6	0.4	0.8
Reaction Time	0.2	0.3	0.6	0.5	0.3	-0.8
Schizophrenia (2014)	0.2	0.5	1.1	0.2	0.5	-1.1
Lung FEV1/FVC ratio	0.2	1.2	2.3	-1.5	-0.4	1.1
Tanning	0.2	2.9	3.8	2.0	1.9	-1.1
Systolic blood pressure, automated reading	0.2	0.5	1.2	0.1	0.4	1.1
Average weekly fortified wine intake	0.2	0.2	0.2	0.4	0.4	0.5
Trunk fat mass	0.2	0.7	1.2	-1.1	-0.6	-0.7
Alcohol usually taken with meals	0.2	0.3	0.4	0.5	0.5	0.6
Qualifications: None of the above	0.2	0.3	0.7	-0.5	-0.3	0.8
Mouth/teeth dental problems	0.2	0.3	0.4	-0.5	-0.7	-0.6
Fluid intelligence score	0.2	0.5	0.9	-0.5	-0.5	-1.0
Alcohol intake versus 10 years previously	0.2	0.3	0.5	-0.3	-0.5	0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.6	-0.6	-0.8	-0.3
Tense / ‘highly strung’	0.2	0.3	0.8	-0.4	-0.3	-0.9
Medication: Paracetamol	0.2	0.3	0.5	0.7	0.6	0.3
Worry too long after embarrassment	0.2	0.4	0.6	0.8	0.8	-0.2
Health satisfaction	0.2	0.2	0.4	0.3	0.7	-0.2
Shortness of breath walking on level ground	0.2	0.3	0.5	-0.1	0.5	-0.7
Emphysema/chronic bronchitis	0.2	0.3	0.4	0.5	0.6	0.4
Migraine (self-reported)	0.2	0.2	0.6	-0.0	0.1	-0.8
Medication: Ibuprofen	0.2	0.3	0.5	0.7	0.6	0.2
Suffer from ‘nerves’	0.2	0.4	0.5	-0.7	-0.7	-0.4
Had major operations	0.2	0.2	0.3	-0.6	-0.5	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.4	-0.6	-0.7	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.7	-0.4	0.1
Friendships satisfaction	0.2	0.3	0.5	-0.7	-0.5	0.1
Back pain experienced in last month	0.2	0.2	0.4	-0.4	-0.6	-0.4
Breast cancer (self-reported)	0.2	0.2	0.5	-0.5	-0.7	0.2
Average weekly champagne plus white wine intake	0.2	0.2	0.5	-0.4	-0.3	-0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	-0.3	-0.7	0.3
Ever depressed for a whole week	0.2	0.2	0.4	0.6	0.6	0.1
Pain experienced in last month	0.2	0.3	0.6	-0.8	-0.3	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	0.0	0.4	0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.8	0.5	0.9	-0.0
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.6	0.0	0.0	-0.8
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	0.5	0.4	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.6	0.2	0.3	-0.8
Crohns Disease (2012)	0.1	0.2	0.5	-0.1	-0.3	0.7
Mean Putamen Volume	0.1	0.1	0.1	-0.3	0.1	0.3
Lupus	0.1	0.1	0.3	-0.1	-0.0	-0.6
Primary Biliary Cirrhosis	0.1	0.2	0.5	0.2	0.3	0.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.4	0.1	-0.3
Diabetes (father)	0.1	0.1	0.2	-0.2	0.1	-0.5
Trunk fat percentage	0.1	0.3	0.5	0.1	0.7	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	-0.0	0.3	0.7
Neuroticism score	0.1	0.1	0.3	-0.0	-0.4	0.5
Arm fat percentage (right)	0.1	0.2	0.6	-0.8	-0.0	-0.3
Medication: Lansoprazole	0.1	0.1	0.1	0.4	-0.1	-0.2
Birth weight of first child	0.1	0.1	0.2	-0.3	-0.5	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.4	-0.5	0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	0.5	0.1	0.4
Body fat percentage	0.1	0.2	0.3	-0.1	0.6	-0.6
Leg fat percentage (right)	0.1	0.2	0.3	-0.3	0.5	-0.6
Number of full sisters	0.1	0.1	0.3	-0.1	-0.1	-0.6
Overall health rating	0.1	0.1	0.3	-0.1	0.2	0.6
Leg pain on walking	0.1	0.2	0.4	0.6	0.4	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.3	-0.1	-0.6
Diabetes diagnosed by doctor	0.1	0.2	0.2	0.4	0.5	0.2
Ever taken oral contraceptive pill	0.1	0.1	0.3	-0.3	0.1	-0.5
Commuting to job workplace: Cycle	0.1	0.1	0.1	0.3	0.1	0.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	-0.1	-0.0	-0.2
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	0.1	-0.2	-0.2
Financial difficulties in last 2 years	0.0	0.0	0.1	-0.0	0.3	0.2
Noisy workplace	0.0	0.1	0.1	0.3	0.1	0.3
Number of full brothers	0.0	0.0	0.0	0.1	0.1	-0.1
Arm fat percentage (left)	0.0	0.2	0.5	-0.7	-0.0	-0.2
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.1	-0.3	0.0
Leg fat percentage (left)	0.0	0.2	0.2	-0.4	0.4	-0.4
Age started oral contraceptive pill	0.0	0.1	0.2	0.2	0.4	0.1

Hub : Genes

HSD17B6

Models

Trait associations