TWAS hub - HSPG2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1970	0.0540	2.5e-04	0.199	NA	0.184	NA	0.193	3.7e-16	NA	6.3e-15	NA	1.3e-15
2	GTEx	Esophagus Mucosa	0.2430	0.0570	3.9e-05	0.107	NA	0.126	NA	0.137	1.3e-07	NA	9.7e-09	NA	2.1e-09
3	GTEx	Nerve Tibial	0.4032	0.0561	1.9e-09	0.377	NA	0.374	NA	0.376	5.2e-28	NA	9.6e-28	NA	6.2e-28
4	GTEx	Skin Not Sun Exposed Suprapubic	0.2330	0.0720	4.5e-03	0.186	NA	0.111	NA	0.166	1.8e-10	NA	1.2e-06	NA	2.0e-09
5	GTEx	Skin Sun Exposed Lower leg	0.1780	0.0580	4.1e-03	0.182	NA	0.177	NA	0.178	6.0e-15	NA	1.6e-14	NA	1.2e-14
6	TCGA	Brain Lower Grade Glioma	0.0869	0.0374	2.1e-06	0.037	0.054	0.043	NA	0.051	4.4e-05	9.1e-07	1.2e-05	NA	1.9e-06
7	TCGA	Lung Adenocarcinoma	0.0431	0.0243	4.3e-03	0.000	0.004	0.003	NA	-0.001	3.4e-01	9.0e-02	1.3e-01	NA	5.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Father’s age at death	4.2	5.6	6.7	-2.6	-2.5	-2.6	-2.6	-2.6	1.6	-1.8
Lupus	3.8	5.7	7.5	-2.7	-2.2	-2.7	-2.7	-2.7	-0.1	-2.2
Leg pain on walking	3.5	4.4	6.9	-2.4	-2.6	-2.4	-2.4	-2.4	-0.7	-0.2
Hayfever/allergic rhinitis (self-reported)	3.4	4.5	6.5	-2.1	-2.5	-2.1	-2.1	-2.1	2.2	-1.6
Age started oral contraceptive pill	3.1	3.9	5.0	-2.2	-2.2	-2.2	-2.2	-2.2	-0.2	-1.8
Medication for hormone replacement therapy	2.9	3.3	5.6	2.0	2.4	2.0	2.0	2.0	1.1	0.4
Ever unenthusiastic/disinterested for a whole week	2.7	3.2	4.1	-2.0	-1.9	-2.0	-2.0	-2.0	1.1	-1.2
HbA1C	2.3	2.6	3.4	-1.7	-1.3	-1.7	-1.7	-1.7	-1.9	1.2
Length of working week for main job	2.3	2.6	3.7	1.9	1.7	1.9	1.9	1.9	0.5	-0.1
Hair/balding pattern: Pattern 2	2.2	2.7	3.8	1.9	2.0	1.9	1.9	1.9	-0.1	0.9
Serious illness, injury or assault to yourself	2.1	2.5	3.9	-2.0	-1.3	-2.0	-2.0	-2.0	0.0	-0.2
Pain all over the body in last month	2.0	2.1	3.0	-1.7	-1.5	-1.7	-1.7	-1.7	-0.7	-0.2
Noisy workplace	2.0	2.5	5.6	-1.4	-1.7	-1.4	-1.4	-1.4	1.1	-2.4
Ever had hysterectomy (womb removed)	1.9	2.1	6.0	-1.3	-1.4	-1.3	-1.3	-1.3	-2.4	0.1
Taking other prescription medications	1.9	2.9	4.4	-2.1	-1.5	-2.1	-2.1	-2.1	-0.5	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	4.4	-1.3	-1.7	-1.3	-1.3	-1.3	1.1	-2.1
Mother’s age at death	1.9	2.4	4.4	-1.7	-2.1	-1.6	-1.7	-1.7	0.0	-1.0
Tinnitus: Yes, but not now, but have in the past	1.8	2.0	2.9	-1.7	-0.7	-1.7	-1.7	-1.7	-0.8	1.1
Medication for cholesterol, blood pressure or diabetes	1.8	3.1	5.0	2.2	1.1	2.2	2.2	2.2	0.1	-0.5
Bipolar Disorder (2018)	1.7	2.7	4.0	2.0	1.6	2.0	2.0	2.0	0.6	0.0
Systolic Blood Pressure	1.7	8.6	20.6	2.7	1.5	2.7	2.7	2.7	-2.7	4.5
Allergy or Eczema	1.7	4.6	5.3	-2.2	-2.3	-2.2	-2.2	-2.2	1.6	-2.3
Mineral and other dietary supplements	1.7	2.2	3.0	1.7	1.2	1.7	1.7	1.7	0.4	1.3
Mean Putamen Volume	1.6	1.9	7.4	0.9	-0.3	0.9	0.9	0.9	-2.7	1.6
Lung cancer (father)	1.6	1.8	2.6	1.4	1.6	1.4	1.4	1.4	0.4	1.4
Medication: Allopurinol	1.6	2.1	4.7	-1.2	-1.6	-1.2	-1.2	-1.2	2.2	-1.2
Illnesses of siblings: Diabetes	1.6	1.9	2.9	-1.7	-1.2	-1.7	-1.7	-1.7	-0.7	0.3
Lung FEV1/FVC ratio	1.5	7.6	33.1	-0.7	-1.0	-0.7	-0.7	-0.7	-5.8	4.1
Medication: Co-codamol	1.5	1.7	2.6	-1.6	-1.0	-1.6	-1.6	-1.6	-0.7	-0.2
Pulse wave Arterial Stiffness index	1.5	1.8	2.4	-1.5	-0.7	-1.5	-1.5	-1.5	1.6	-0.9
Coronary Artery Disease (CAD)	1.4	1.7	2.4	-1.5	-1.6	-1.5	-1.5	-1.5	0.2	-0.4
Cardiovascular Disease	1.4	4.7	9.4	1.8	2.3	1.8	1.8	1.8	-2.2	3.1
Exposure to tobacco smoke at home	1.4	1.6	2.4	-1.2	-0.7	-1.2	-1.2	-1.2	-1.6	1.5
Gout (self-reported)	1.4	1.9	3.5	-1.3	-1.6	-1.3	-1.3	-1.3	1.9	-0.7
Chronic bronchitis/emphysema (mother)	1.4	1.6	2.3	1.5	1.3	1.5	1.5	1.5	-0.6	0.1
Exposure to tobacco smoke outside home	1.4	1.9	2.5	-1.5	-1.5	-1.5	-1.5	-1.5	-1.6	0.3
Medication: Gliclazide	1.4	1.5	2.1	-1.4	-1.4	-1.4	-1.4	-1.4	-0.2	0.6
Diastolic blood pressure, automated reading	1.4	4.4	7.6	2.2	0.5	2.2	2.2	2.2	-1.5	2.8
Schizophrenia vs Biploar Disorder	1.3	1.7	2.4	-1.5	-1.2	-1.5	-1.5	-1.5	-0.3	0.8
Pack years adult smoking proportion	1.3	2.0	2.8	1.7	1.5	1.7	1.7	1.7	0.1	0.7
Hayfever, allergic rhinitis or eczema	1.3	2.8	5.3	-1.2	-2.0	-1.2	-1.2	-1.2	2.3	-2.1
High blood pressure (mother)	1.3	1.9	5.6	1.2	0.6	1.2	1.2	1.2	-2.4	1.0
Falls in the last year	1.3	1.8	8.8	-0.3	0.4	-0.3	-0.3	-0.3	-3.0	1.7
Pulse wave peak to peak time	1.3	1.6	2.4	1.4	0.6	1.4	1.4	1.4	-1.6	0.8
Medication: Atorvastatin	1.3	1.6	2.3	-1.5	-1.0	-1.5	-1.5	-1.5	0.5	-0.9
Breast Cancer	1.2	2.8	9.0	0.7	-0.1	0.7	0.7	0.7	3.0	-3.0
Sensitivity / hurt feelings	1.2	2.1	7.0	1.1	0.9	1.1	1.1	1.1	2.6	-1.4
Relative age voice broke	1.2	1.9	2.7	1.7	1.0	1.7	1.7	1.7	0.5	0.9
Number of live births	1.2	1.7	6.5	-0.8	-0.4	-0.8	-0.8	-0.8	-2.5	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	3.3	1.8	1.1	1.8	1.8	1.8	-1.2	1.5
Medication: Metformin	1.1	1.5	2.2	-1.4	-1.5	-1.4	-1.4	-1.4	-0.7	-0.2
Neuroticism score	1.1	2.3	9.1	1.2	0.3	1.2	1.2	1.2	3.0	-1.2
Mouth/teeth dental problems: Dentures	1.1	1.8	2.9	-1.7	-0.8	-1.7	-1.7	-1.7	-0.4	0.6
Number of children fathered	1.1	1.3	2.4	-1.2	-1.6	-1.2	-1.2	-1.2	-0.6	0.4
Rheumatoid Arthritis	1.0	1.3	2.0	1.4	0.9	1.4	1.4	1.4	0.5	-0.4
Triglycerides	1.0	1.7	5.0	-1.2	-0.8	-1.2	-1.2	-1.2	-2.2	0.7
Qualifications: None of the above	1.0	2.1	2.8	1.5	1.6	1.5	1.5	1.5	-0.8	1.7
Allergy	1.0	2.2	5.7	0.9	2.4	0.9	0.9	0.9	-1.3	2.2
Asthma	1.0	1.9	6.1	-1.2	-2.5	-1.2	-1.2	-1.2	-1.0	-0.6
Prospective memory result	1.0	1.2	1.9	-1.3	-1.4	-1.3	-1.3	-1.3	-0.6	-0.1
Worry too long after embarrassment	1.0	1.6	7.7	0.0	-0.7	0.0	0.0	0.0	2.8	-1.8
Medication: Aspirin	1.0	1.3	1.4	1.2	0.9	1.2	1.2	1.2	-1.1	1.1
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	5.6	1.1	2.4	1.1	1.1	1.1	-0.4	-0.8
Leg fat percentage (left)	1.0	3.6	7.5	-1.4	-1.7	-1.5	-1.4	-1.4	-2.7	2.6
Supplements: Calcium	1.0	1.1	4.1	0.0	-0.9	0.0	0.0	0.0	1.6	-2.0
Heart disease (siblings)	1.0	1.2	2.0	-1.0	-1.4	-1.0	-1.0	-1.0	0.6	-1.2
Pack years of smoking	1.0	1.4	2.1	1.4	1.5	1.3	1.4	1.4	0.5	0.3
Worry (Nagel 2018)	0.9	1.8	3.9	1.4	0.5	1.4	1.4	1.4	2.0	0.9
Reaction Time	0.9	1.8	2.7	1.5	0.8	1.5	1.5	1.5	-0.7	1.6
Primary Biliary Cirrhosis	0.9	1.3	1.7	-1.3	-1.1	-1.3	-1.3	-1.3	-0.7	-0.8
Heel T-Score	0.9	7.4	23.7	2.3	-0.9	2.3	2.3	2.3	-4.9	2.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	1.6	-1.2	-0.4	-1.2	-1.2	-1.2	-1.2	-0.3
Diabetes (father)	0.9	1.1	1.9	1.1	0.8	1.1	1.1	1.1	1.4	-0.5
Medication: Ramipril	0.9	1.2	4.3	0.9	2.1	0.9	0.9	0.9	-0.6	0.7
Peak expiratory flow (PEF)	0.9	2.2	2.6	1.6	1.2	1.6	1.6	1.6	-1.3	1.4
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.7	-1.1	-1.7	-1.1	-1.1	-1.1	0.2	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.0	0.6	1.3	0.6	0.6	0.6	-1.4	1.2
Hearing aid user	0.9	1.0	2.3	0.9	0.8	0.9	0.9	0.9	-0.9	1.5
Commuting to job workplace: Public transport	0.9	1.1	3.9	-0.3	0.2	-0.3	-0.3	-0.3	2.0	-1.9
Fractured/broken bones in last 5 years	0.9	1.1	2.4	-0.8	-0.9	-0.8	-0.8	-0.8	1.5	-1.5
Bipolar Disorder or Schizophrenia	0.8	1.9	2.5	1.6	1.4	1.6	1.6	1.6	-0.1	1.1
Age at First Birth	0.8	1.2	3.8	-0.7	-1.5	-0.7	-0.7	-0.7	1.9	-0.4
Body Mass Index (BMI) (2010)	0.8	1.1	2.6	0.6	1.5	0.6	0.6	0.6	-1.6	1.1
Waist Hip Ratio (WHR)	0.8	3.7	17.6	-0.8	-0.5	-0.8	-0.8	-0.8	-4.2	2.3
Chronotype (morning person)	0.8	1.8	2.9	-1.7	-0.6	-1.7	-1.7	-1.7	-0.8	-0.1
Supplements: Zinc	0.8	0.9	2.3	0.7	0.2	0.7	0.7	0.7	1.3	-1.5
Sitting height	0.8	6.0	24.3	1.4	-0.4	1.4	1.4	1.4	4.9	-3.0
Worrier / anxious feelings	0.8	1.5	2.2	1.5	1.1	1.5	1.5	1.5	0.5	0.7
Forced expiratory volume in 1-second (FEV1)	0.8	2.5	4.9	1.6	0.9	1.5	1.6	1.6	-1.5	2.2
Leg fat percentage (right)	0.8	3.1	7.1	-1.2	-1.3	-1.2	-1.2	-1.2	-2.7	2.6
Age at first live birth	0.8	1.4	4.7	0.9	0.0	0.9	0.9	0.9	2.2	-1.4
Average weekly red wine intake	0.8	1.3	1.7	1.2	0.1	1.3	1.2	1.2	1.3	-0.9
Loneliness, isolation	0.8	1.2	3.3	1.1	0.5	1.1	1.1	1.1	1.8	-0.3
Medication for cholesterol	0.8	1.2	2.6	-0.8	-1.6	-0.8	-0.8	-0.8	1.0	-1.4
Illnesses of father: None of the above (group 1)	0.8	1.0	1.3	1.1	0.9	1.1	1.1	1.1	1.2	-0.3
Miserableness	0.8	1.4	2.0	1.4	0.7	1.4	1.4	1.4	-0.3	1.1
Medication: Lisinopril	0.8	1.0	1.7	-1.3	-0.7	-1.3	-1.3	-1.3	-0.3	-0.1
Average weekly beer plus cider intake	0.8	1.2	1.7	-1.3	-1.0	-1.3	-1.3	-1.3	0.2	-0.6
Commuting to job workplace: Cycle	0.8	0.9	3.5	-0.6	-0.2	-0.6	-0.6	-0.6	1.9	-1.2
Major Depression (MDD)	0.7	0.9	4.7	0.0	-0.1	-1.1	0.0	0.0	-0.7	2.2
Fasting Glucose	0.7	0.9	1.4	-1.2	-0.7	-1.2	-1.2	-1.2	0.1	-0.0
Respiratory disease	0.7	1.5	4.0	-1.2	-2.0	-1.2	-1.2	-1.2	-0.2	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.8	-0.8	-1.7	-0.8	-0.8	-0.8	0.8	-1.0
Qualifications: CSEs or equivalent	0.7	0.9	1.8	0.8	1.1	0.7	0.8	0.8	-1.4	1.0
Supplements: Glucosamine	0.7	0.9	1.3	-1.1	-0.3	-1.1	-1.1	-1.1	-1.1	-0.3
Hair/balding pattern: Pattern 3	0.7	1.0	2.5	-0.9	-0.9	-0.8	-0.9	-0.9	0.9	-1.6
Medication: Cholesterol lowering	0.7	1.2	1.6	-1.3	-0.9	-1.2	-1.3	-1.3	0.4	-0.9
Glaucoma (self-reported)	0.7	0.8	2.8	-0.2	1.0	-0.2	-0.2	-0.2	1.7	-1.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	4.4	-0.7	-2.1	-0.7	-0.7	-0.7	-1.6	0.8
Medication: Amlodipine	0.7	1.0	1.4	-1.2	-0.7	-1.2	-1.2	-1.2	-0.8	0.3
Birth weight	0.7	1.6	6.7	0.3	0.8	0.3	0.3	0.3	2.6	-1.8
Medication: Ibuprofen	0.7	0.8	1.2	-1.1	-0.7	-1.1	-1.1	-1.1	-0.6	0.6
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.8	0.2	-0.0	0.2	0.2	0.2	-1.9	1.3
Illnesses of father: Heart disease	0.7	1.0	1.2	-1.1	-1.0	-1.1	-1.1	-1.1	0.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.1	1.4	0.8	1.4	1.4	1.4	0.6	-1.1
Handedness (chirality/laterality): Left-handed	0.7	0.9	3.8	-0.2	0.4	-0.2	-0.2	-0.2	-1.4	2.0
Long-standing illness, disability or infirmity	0.7	1.1	3.6	-0.5	-0.2	-0.5	-0.5	-0.5	-1.9	1.7
Asthma (self-reported)	0.7	1.5	5.3	-0.9	-2.3	-1.0	-0.9	-0.9	-0.9	-0.8
Medication: Blood pressure	0.7	1.4	5.1	-0.1	0.3	-0.1	-0.1	-0.1	-2.3	2.1
Alzheimer’s Disease (in mother)	0.6	0.8	1.2	-1.0	-1.1	-1.0	-1.0	-1.0	-0.2	0.6
Smoking Status	0.6	1.3	2.2	-1.5	-0.7	-1.5	-1.5	-1.5	0.6	0.1
Neuroticism	0.6	1.3	7.7	0.4	-0.1	0.4	0.4	0.4	2.8	-1.0
Systolic blood pressure, automated reading	0.6	1.6	6.2	0.5	-0.2	0.5	0.5	0.5	-2.0	2.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.0	1.0	0.5	1.0	1.0	1.0	-0.4	0.6
Body mass index (BMI)	0.6	2.8	6.5	-1.0	-1.7	-1.1	-1.0	-1.0	-2.5	2.3
Waist circumference	0.6	2.1	4.6	-0.9	-1.5	-0.9	-0.9	-0.9	-2.1	2.1
Illnesses of siblings	0.6	0.9	1.0	1.0	1.0	1.0	1.0	1.0	1.0	-0.8
Impedance of arm (right)	0.6	2.8	6.2	1.4	1.7	1.4	1.4	1.4	2.5	-1.8
Alcohol intake versus 10 years previously	0.6	0.9	3.2	-0.4	-0.1	-0.4	-0.4	-0.4	-1.6	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	2.7	1.6	0.8	1.6	1.6	1.6	-0.7	0.9
Standing height	0.6	6.3	13.0	2.5	0.6	2.5	2.5	2.5	3.6	-2.2
Hair/balding pattern: Pattern 4	0.6	1.4	4.8	-0.6	0.6	-0.6	-0.6	-0.6	-2.2	1.8
High blood pressure (siblings)	0.6	0.9	2.9	0.0	0.7	0.0	0.0	0.0	-1.7	1.7
Body fat percentage	0.6	2.3	5.5	-0.9	-1.4	-1.0	-0.9	-0.9	-2.4	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	3.0	-0.5	-1.0	-0.5	-0.5	-0.5	-1.7	0.3
Shortness of breath walking on level ground	0.6	0.7	1.0	-1.0	-1.0	-1.0	-1.0	-1.0	0.3	-0.1
Suffer from ‘nerves’	0.6	0.9	1.4	1.2	0.6	1.2	1.2	1.2	0.7	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.6	-0.7	-0.2	-0.7	-0.7	-0.7	-0.5	1.6
Breast cancer (self-reported)	0.6	0.7	2.2	-0.7	-1.5	-0.7	-0.7	-0.7	-0.5	0.7
Average weekly champagne plus white wine intake	0.6	0.8	0.9	1.0	0.7	1.0	1.0	1.0	-0.9	0.8
Illnesses of father: High blood pressure	0.6	0.7	0.9	-0.9	-0.5	-0.9	-0.9	-0.9	-0.9	0.7
Neuroticism (Nagel 2018)	0.5	1.2	4.3	1.0	0.5	1.0	1.0	1.0	2.1	0.1
Prostate Cancer	0.5	0.7	1.3	1.0	0.3	0.9	1.0	1.0	0.1	-1.1
Neuroticism (2016)	0.5	0.8	2.1	-0.9	-0.6	-0.9	-0.9	-0.9	1.5	-0.2
Blood Eosinophil Count	0.5	4.2	5.0	-2.2	-2.1	-2.2	-2.2	-2.2	-0.7	-2.2
Height	0.5	10.6	34.0	2.6	1.3	2.6	2.6	2.6	5.8	-3.4
Relative age of first facial hair	0.5	1.0	2.0	1.0	1.4	1.0	1.0	1.0	0.8	0.6
Diabetes (mother)	0.5	0.6	2.6	0.5	-0.1	0.5	0.5	0.5	-0.8	1.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	0.9	-0.9	-0.2	-0.9	-0.9	-0.9	-0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.8	1.3	-0.3	1.3	1.3	1.3	-0.4	0.6
Medication: Atenolol	0.5	0.6	0.9	-0.8	-0.3	-0.8	-0.8	-0.8	1.0	0.4
Hearing difficulty/problems with background noise	0.5	0.9	3.1	0.4	1.5	0.4	0.4	0.4	1.8	-0.2
Forced vital capacity (FVC)	0.5	1.8	2.8	1.7	0.9	1.7	1.7	1.7	0.4	0.8
Heart attack	0.5	0.6	2.2	0.5	1.5	0.5	0.5	0.5	-0.2	1.2
Medication: Lansoprazole	0.5	0.6	0.8	-0.9	0.6	-0.9	-0.9	-0.9	-0.6	0.6
Medication: Blood pressure	0.5	0.9	1.3	-1.1	-0.0	-1.1	-1.1	-1.1	0.4	1.1
Medication: Seretide 50 evohaler	0.5	0.5	1.6	-0.6	-1.3	-0.6	-0.6	-0.6	-1.0	-0.1
Mean time to correctly identify matches	0.5	0.9	1.5	1.1	0.6	1.1	1.1	1.1	0.1	1.2
Heart disease (mother)	0.5	0.6	1.0	0.6	1.0	0.6	0.6	0.6	1.0	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.4	-0.1	-0.3	-0.2	-0.1	-0.1	-1.4	1.5
Age at last live birth	0.5	0.7	2.1	0.8	-0.1	0.8	0.8	0.8	1.5	-0.8
Ever had bowel cancer screening	0.5	0.6	1.4	0.6	0.9	0.6	0.6	0.6	-0.3	1.2
Eye problems/disorders: Cataract	0.5	0.6	2.6	-0.1	-0.9	-0.1	-0.1	-0.1	0.9	-1.6
Medication: Aspirin	0.5	0.7	1.0	0.9	0.6	0.9	0.9	0.9	-0.7	1.0
Ever taken oral contraceptive pill	0.5	0.5	0.8	-0.9	-0.9	-0.9	-0.9	-0.9	0.2	0.0
Eye problems/disorders: Glaucoma	0.5	0.6	2.2	-0.0	0.7	-0.0	-0.0	-0.0	1.5	-1.3
Irritability	0.5	0.9	1.4	1.2	0.3	1.2	1.2	1.2	0.3	-0.4
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.8	-0.7	0.0	-0.7	-0.7	-0.7	1.4	0.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.8	-0.5	-1.0	-0.5	-0.5	-0.5	1.3	-0.6
Pain experienced in last month	0.5	0.9	2.7	-0.6	0.0	-0.6	-0.6	-0.6	1.4	-1.7
Alcohol drinker status: Previous	0.5	0.6	1.7	0.6	1.3	0.6	0.6	0.6	0.7	0.4
Leg fat mass (left)	0.5	1.9	4.9	-0.6	-1.4	-0.6	-0.6	-0.6	-2.2	2.2
Depressed Affect (Nagel 2018)	0.4	0.9	2.1	0.9	0.9	0.9	0.9	0.9	1.4	0.3
Alzheimer’s Disease (including proxy)	0.4	0.5	1.0	-0.8	-0.6	-0.8	-0.8	-0.8	-0.4	1.0
Schizophrenia (2014)	0.4	0.8	2.2	0.7	0.8	0.7	0.7	0.7	-0.8	1.5
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.7	0.9	0.5	0.9	0.9	0.9	-0.2	0.7
Blood Platelet Count	0.4	4.1	8.9	-1.9	-2.1	-1.9	-1.9	-1.9	0.9	-3.0
BMI	0.4	2.5	7.5	-1.1	-1.9	-1.1	-1.1	-1.1	-2.7	1.1
Hypothyroidism (self reported)	0.4	1.0	5.1	-0.5	-2.2	-0.5	-0.5	-0.5	-1.0	-0.1
Hand grip strength (left)	0.4	1.0	2.2	-0.7	-1.5	-0.7	-0.7	-0.7	-1.5	0.8
Number of treatments/medications taken	0.4	0.7	1.0	-1.0	-0.5	-1.0	-1.0	-1.0	-0.4	0.4
Hearing difficulty/problems: Yes	0.4	0.6	0.9	-1.0	0.4	-1.0	-1.0	-1.0	-0.0	0.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	2.6	0.0	0.1	0.0	0.0	0.0	-1.6	0.5
Vitamin and mineral supplements	0.4	0.5	1.3	0.7	-0.1	0.7	0.7	0.7	-1.1	0.5
Trunk fat percentage	0.4	1.8	4.7	-0.7	-1.1	-0.7	-0.7	-0.7	-2.1	2.2
Hand grip strength (right)	0.4	1.0	2.8	-0.6	-1.5	-0.7	-0.6	-0.6	-1.7	0.4
Average weekly fortified wine intake	0.4	0.5	2.4	-0.4	0.2	-0.4	-0.4	-0.4	0.4	-1.6
Medication: Levothyroxine sodium	0.4	0.7	2.1	-0.7	-1.4	-0.7	-0.7	-0.7	-0.5	-0.6
Number of incorrect matches in round	0.4	0.6	3.0	0.6	0.2	0.6	0.6	0.6	0.1	1.7
Past tobacco smoking	0.4	0.7	1.4	0.7	0.3	0.7	0.7	0.7	-1.2	-1.0
Nervous feelings	0.4	0.7	2.6	0.7	0.4	0.7	0.7	0.7	1.6	-0.0
Had other major operations	0.4	0.4	1.8	0.4	1.4	0.4	0.4	0.4	0.7	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.3	1.2	-0.3	1.2	1.2	1.2	-0.2	0.5
Time employed in main current job	0.4	0.5	0.9	-0.6	0.7	-0.6	-0.6	-0.6	-0.9	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.7	-0.8	-0.5	-0.9	-0.8	-0.8	-0.8	0.3
Impedance of arm (left)	0.4	2.0	3.8	1.1	1.7	1.1	1.1	1.1	2.0	-1.5
Birth weight of first child	0.4	0.8	5.5	0.2	-0.3	0.2	0.2	0.2	2.4	0.1
Forced vital capacity (FVC), Best measure	0.4	1.6	2.5	1.6	0.6	1.6	1.6	1.6	0.9	-0.2
Health satisfaction	0.4	0.6	1.2	-0.6	-0.9	-0.6	-0.6	-0.6	-0.8	1.1
Leg fat mass (right)	0.4	1.6	4.7	-0.5	-1.2	-0.5	-0.5	-0.5	-2.1	2.2
Overall health rating	0.4	0.9	3.1	0.8	0.5	0.8	0.8	0.8	-0.7	1.8
Family relationship satisfaction	0.4	0.4	0.6	0.8	0.4	0.8	0.8	0.8	0.1	0.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.4	0.6	1.2	0.6	0.6	0.6	-0.3	0.7
Hypertension (Self-reported)	0.4	1.0	6.5	0.1	0.5	0.1	0.1	0.1	-0.7	2.5
Arm fat percentage (left)	0.4	1.5	5.0	-0.5	-0.9	-0.5	-0.5	-0.5	-2.0	2.2
Commuting to job workplace: Walk	0.4	0.5	0.7	0.8	-0.3	0.8	0.8	0.8	-0.9	-0.0
Osteoporosis (self-reported)	0.4	0.5	0.6	0.8	0.5	0.8	0.8	0.8	0.6	0.5
Osteoarthritis (self-reported)	0.4	0.5	1.3	0.1	0.9	0.1	0.1	0.1	-1.1	1.1
Arm fat mass (left)	0.4	1.6	4.1	-0.6	-1.4	-0.6	-0.6	-0.6	-2.0	1.9
Guilty feelings	0.4	0.6	1.0	0.9	0.3	0.9	0.9	0.9	1.0	-0.2
Medication: Bendroflumethiazide	0.4	0.6	3.2	0.5	0.1	0.5	0.5	0.5	-0.4	1.8
Myopia	0.4	0.6	1.7	-0.7	-1.3	-0.7	-0.7	-0.7	-0.8	-0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.8	0.4	1.3	0.4	0.4	0.4	-0.1	1.2
Depression (Nagel 2018)	0.3	0.5	0.9	0.7	0.3	0.7	0.7	0.7	1.0	0.6
Crohns Disease (2017)	0.3	0.6	2.5	-0.1	-0.8	-0.1	-0.1	-0.1	0.9	-1.6
Irritable Bowel Disease (IBD)	0.3	0.8	2.0	-0.2	-1.2	-0.1	-0.2	-0.2	1.4	-1.4
Crohns Disease (2012)	0.3	0.4	0.9	-0.5	-1.0	-0.5	-0.5	-0.5	-0.3	-1.0
LDL Cholesterol	0.3	0.4	2.5	0.1	-0.4	0.1	0.1	0.1	-1.6	0.6
Blood Red Count	0.3	2.5	3.1	1.7	0.1	1.7	1.7	1.7	-1.5	1.8
Blood White Count	0.3	2.5	7.2	-0.9	-0.0	-0.8	-0.9	-0.9	2.7	-2.7
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.5	-0.5	-1.2	-0.5	-0.5	-0.5	-0.6	-0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.7	0.2	1.3	0.3	0.2	0.2	-0.6	-0.1
Townsend deprivation index at recruitment	0.3	0.4	1.9	-0.1	-0.6	-0.1	-0.1	-0.1	0.6	-1.4
Fed-up feelings	0.3	0.6	0.9	0.8	0.6	0.8	0.8	0.8	0.9	0.3
High blood pressure	0.3	0.9	5.3	0.3	0.6	0.3	0.3	0.3	0.1	2.3
Chronic bronchitis/emphysema (father)	0.3	0.3	0.6	-0.6	0.3	-0.6	-0.6	-0.6	-0.8	-0.3
Trunk fat mass	0.3	1.3	3.3	-0.5	-1.3	-0.6	-0.5	-0.5	-1.6	1.8
Alcohol usually taken with meals	0.3	0.5	0.8	0.9	0.1	0.9	0.9	0.9	-0.4	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.7	0.2	-0.7	0.2	0.2	0.2	0.7	-1.3
Fluid intelligence score	0.3	0.5	0.7	0.8	0.8	0.8	0.8	0.8	0.0	0.6
Arm fat percentage (right)	0.3	1.3	5.1	-0.3	-0.9	-0.3	-0.3	-0.3	-1.8	2.3
Happiness	0.3	0.4	0.7	-0.7	-0.7	-0.6	-0.7	-0.7	0.8	-0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.3	-0.7	-1.1	-0.7	-0.7	-0.7	-1.0	-1.1
Arm fat mass (right)	0.3	1.2	3.4	-0.2	-1.2	-0.2	-0.2	-0.2	-1.8	1.8
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	-0.7	-0.8	-0.7	-0.7	-0.7	-0.3	0.1
Loud music exposure frequency	0.3	0.3	0.6	0.5	0.6	0.5	0.5	0.5	-0.4	0.8
Blood clot in the leg (DVT)	0.3	0.4	0.5	0.7	0.4	0.7	0.7	0.7	0.5	0.2
Qualifications: College or University degree	0.3	1.1	4.1	0.4	-0.9	0.4	0.4	0.4	1.5	-2.0
Eye problems/disorders: None of the above	0.3	0.3	1.0	0.3	0.5	0.3	0.3	0.3	-0.9	1.0
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.6	0.0	0.8	0.1	0.0	0.0	1.3	-0.7
Angina (self-reported)	0.3	0.4	0.6	-0.7	0.5	-0.7	-0.7	-0.7	0.4	-0.3
Whole body fat mass	0.3	1.4	4.0	-0.4	-1.3	-0.4	-0.4	-0.4	-1.8	2.0
Number of full sisters	0.3	0.3	0.8	-0.5	-0.9	-0.5	-0.5	-0.5	-0.6	-0.4
Had major operations	0.3	0.4	1.1	-0.2	-0.6	-0.2	-0.2	-0.2	1.0	-1.0
Supplements: Vitamin C	0.3	0.3	1.5	0.2	-0.1	0.2	0.2	0.2	-0.8	1.2
Smoking status: Current	0.3	0.4	0.7	-0.7	-0.8	-0.7	-0.7	-0.7	-0.3	0.1
Number of self-reported non-cancer illnesses	0.3	0.6	1.5	-0.5	-0.8	-0.5	-0.5	-0.5	-1.2	1.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	-0.6	-0.6	-0.6	-0.6	-0.6	-0.6	-0.9
High cholesterol (Self-reported)	0.3	0.5	0.8	-0.7	-0.7	-0.7	-0.7	-0.7	-0.9	-0.1
Ever smoked	0.3	0.5	1.7	0.0	0.1	0.0	0.0	0.0	1.3	1.3
Risk taking	0.3	0.5	2.5	-0.0	-1.6	-0.0	-0.0	-0.0	-0.1	-0.9
Cholesterol lowering medication	0.3	0.5	2.9	-0.0	0.8	-0.0	-0.0	-0.0	-1.7	0.3
Schizophrenia (2018)	0.2	0.4	1.7	0.4	0.5	0.4	0.4	0.4	-0.6	1.3
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.4	0.7	0.4	0.4	0.4	0.3	0.8
Ulcerative Colitis (UC)	0.2	0.3	1.0	-0.1	-0.8	-0.1	-0.1	-0.1	1.0	-0.6
Ovarian Cancer	0.2	0.3	0.8	0.2	-0.9	0.2	0.2	0.2	0.9	-0.7
HDL Cholesterol	0.2	0.4	1.2	-0.2	0.4	-0.2	-0.2	-0.2	1.0	-1.1
Tanning	0.2	2.8	3.3	-1.8	-1.8	-1.8	-1.8	-1.8	0.7	-1.6
Average weekly spirits intake	0.2	0.3	1.1	0.1	1.0	0.1	0.1	0.1	-0.7	-0.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	0.7	-0.2	0.7	0.7	0.7	0.3	0.1
Angina	0.2	0.3	0.4	-0.5	0.6	-0.5	-0.5	-0.5	0.6	-0.4
Maternal smoking around birth	0.2	0.2	0.3	-0.5	0.3	-0.5	-0.5	-0.5	-0.4	0.5
Multivitamins +/- minerals	0.2	0.3	0.4	-0.6	0.0	-0.6	-0.6	-0.6	0.6	-0.5
Stomach or abdominal pain in last month	0.2	0.2	0.7	-0.4	-0.1	-0.4	-0.4	-0.4	-0.4	-0.8
Had menopause	0.2	0.2	0.6	0.5	0.3	0.5	0.5	0.5	0.2	-0.8
Financial difficulties in last 2 years	0.2	0.3	0.5	0.7	0.2	0.7	0.7	0.7	-0.4	0.1
Medication: Simvastatin	0.2	0.3	0.9	-0.5	-0.6	-0.5	-0.5	-0.5	-0.9	-0.4
Pulse rate	0.2	0.3	0.8	-0.4	-0.7	-0.3	-0.4	-0.4	0.9	-0.6
Depression (self-reported)	0.2	0.2	0.7	0.4	-0.1	0.4	0.4	0.4	-0.8	-0.0
Breastfed as a baby	0.2	0.3	0.4	0.6	-0.6	0.6	0.6	0.6	0.3	-0.3
Tense / ‘highly strung’	0.2	0.4	1.6	0.0	-0.8	0.0	0.0	0.0	1.3	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.4	0.5	0.4	0.4	0.4	0.5	0.9
Pulse wave reflection index	0.2	0.3	0.7	-0.5	0.9	-0.5	-0.5	-0.5	0.5	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.3	0.1	0.1	0.1	0.1	0.1	-1.1	1.1
Medication: Paracetamol	0.2	0.4	2.0	-0.1	-0.1	-0.1	-0.1	-0.1	-0.8	1.4
Comparative body size at age 10	0.2	0.5	0.7	-0.7	-0.7	-0.7	-0.7	-0.7	0.7	-0.9
Wheeze or whistling in the chest in last year	0.2	0.3	1.0	-0.6	-0.2	-0.6	-0.6	-0.6	1.0	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.4	0.5	-0.4	-0.4	-0.4	0.7	0.4
Migraine (self-reported)	0.2	0.2	0.2	0.4	0.3	0.4	0.4	0.4	-0.5	-0.4
Alcohol intake frequency.	0.2	0.6	1.5	0.3	0.8	0.3	0.3	0.3	-1.2	1.2
Comparative height size at age 10	0.2	1.4	4.4	1.1	0.3	1.1	1.1	1.1	2.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.9	-0.5	0.9	-0.5	-0.5	-0.5	0.2	-0.2
Smoking status: Previous	0.2	0.2	1.0	-0.3	-0.0	-0.3	-0.3	-0.3	0.6	1.0
Back pain experienced in last month	0.2	0.3	0.7	0.5	0.1	0.5	0.5	0.5	-0.8	0.5
Wears glasses or contact lenses	0.2	0.3	0.4	0.6	0.2	0.6	0.6	0.6	0.6	0.1
Number of operations (self-reported)	0.2	0.2	0.4	-0.6	0.1	-0.6	-0.6	-0.6	0.3	-0.1
Vascular/heart problems diagnosed by doctor	0.2	0.6	3.6	0.0	-0.7	0.0	0.0	0.0	-0.5	-1.9
Basal cell carcinoma (self-reported)	0.2	0.2	1.0	-0.1	0.2	-0.1	-0.1	-0.1	-0.7	1.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	0.5	0.0	0.6	0.5	0.5	0.7	-0.2
Impedance of whole body	0.2	1.2	2.3	1.1	1.5	1.1	1.1	1.1	1.0	-0.7
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	0.9	0.3	0.9	0.9	0.9	0.1	-0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.6	-0.3	-0.5	-0.3	-0.3	-0.3	0.6	-0.8
Ulcerative Colitis	0.1	0.1	0.6	0.0	-0.8	0.0	0.0	0.0	0.5	-0.3
Lung FVC	0.1	0.5	2.0	-0.6	-0.4	-0.6	-0.6	-0.6	-0.4	1.4
Severe depression (siblings)	0.1	0.1	0.4	0.0	0.6	0.0	0.0	0.0	-0.4	-0.0
Impedance of leg (right)	0.1	0.3	1.3	0.5	1.1	0.5	0.5	0.5	0.2	0.1
Leg fat-free mass (left)	0.1	0.3	0.8	0.6	-0.9	0.6	0.6	0.6	0.0	0.3
Current tobacco smoking	0.1	0.2	0.2	-0.5	-0.4	-0.5	-0.5	-0.5	-0.5	0.3
Age when periods started (menarche)	0.1	0.3	1.3	0.0	1.2	0.0	0.0	0.0	-0.1	1.0
Leg predicted mass (left)	0.1	0.3	0.7	0.6	-0.8	0.6	0.6	0.6	-0.0	0.3
Mouth/teeth dental problems	0.1	0.1	0.3	-0.0	-0.5	-0.0	-0.0	-0.0	-0.5	-0.3
Weight	0.1	0.7	2.0	0.0	-1.4	0.0	0.0	0.0	-1.0	1.3
Trunk fat-free mass	0.1	0.5	0.9	0.6	-0.9	0.6	0.6	0.6	0.9	-0.4
Hip circumference	0.1	0.3	1.2	-0.1	-1.1	-0.1	-0.1	-0.1	0.3	0.8
Illnesses of mother	0.1	0.1	0.4	-0.2	0.6	-0.2	-0.2	-0.2	0.0	0.6
Trunk predicted mass	0.1	0.5	1.0	0.7	-0.8	0.7	0.7	0.7	1.0	-0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.5	-0.0	-0.7	-0.0	-0.0	-0.0	0.1	0.1
Headache pain in last month	0.1	0.2	0.4	0.6	0.2	0.6	0.6	0.6	0.3	-0.3
Arm fat-free mass (right)	0.1	0.5	2.5	-0.2	-1.6	-0.2	-0.2	-0.2	-0.6	0.4
Number of full brothers	0.1	0.2	0.8	0.3	0.3	0.3	0.3	0.3	-0.9	0.4
Emphysema/chronic bronchitis	0.1	0.1	0.3	0.1	-0.6	0.1	0.1	0.1	0.5	-0.2
Medication for pain relief, constipation, heartburn	0.1	0.1	0.6	0.1	-0.3	0.1	0.1	0.1	0.1	-0.8
Neck or shoulder pain in last month	0.1	0.1	0.1	0.4	-0.2	0.4	0.4	0.4	-0.1	0.2
Medication: Omeprazole	0.1	0.1	0.5	0.3	-0.1	0.3	0.3	0.3	0.7	0.3
Arm predicted mass (right)	0.1	0.3	1.7	-0.0	-1.3	-0.0	-0.0	-0.0	-0.4	0.5
Pulse rate, automated reading	0.1	0.4	1.7	-0.1	-1.3	-0.1	-0.1	-0.1	0.3	-1.0
Knee pain experienced in last month	0.1	0.1	0.2	-0.4	-0.1	-0.4	-0.4	-0.4	0.2	0.3
Whole body fat-free mass	0.1	0.3	1.3	0.4	-1.1	0.4	0.4	0.4	0.4	-0.1
Leg fat-free mass (right)	0.1	0.3	1.3	0.5	-1.1	0.5	0.5	0.5	0.2	-0.0
Diabetes diagnosed by doctor	0.1	0.2	0.4	-0.4	-0.5	-0.4	-0.4	-0.4	-0.6	-0.2
Friendships satisfaction	0.1	0.1	0.7	0.1	-0.3	0.1	0.1	0.1	0.8	0.3
Whole body water mass	0.1	0.3	1.2	0.5	-1.1	0.5	0.5	0.5	0.5	-0.1
Leg predicted mass (right)	0.1	0.3	1.2	0.5	-1.1	0.5	0.5	0.5	0.2	-0.0
Financial situation satisfaction	0.1	0.1	0.4	-0.2	0.1	-0.2	-0.2	-0.2	0.4	0.7
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.6	-0.2	0.3	-0.2	-0.2	-0.2	-0.7	0.8
Medication: Paracetamol	0.1	0.2	1.5	0.1	-0.1	0.1	0.1	0.1	-0.3	1.2
Alcohol drinker status: Never	0.1	0.2	0.4	-0.4	-0.7	-0.4	-0.4	-0.4	0.1	0.2
Basal metabolic rate	0.1	0.3	1.1	0.5	-1.0	0.5	0.5	0.5	0.0	0.3
Arm fat-free mass (left)	0.1	0.5	2.7	-0.3	-1.6	-0.3	-0.3	-0.3	-0.6	0.5
Ever depressed for a whole week	0.1	0.1	0.6	-0.2	0.4	-0.2	-0.2	-0.2	0.8	0.2
Unable to work because of sickness or disability	0.1	0.2	0.8	-0.0	-0.9	-0.0	-0.0	-0.0	-0.1	0.6
Arm predicted mass (left)	0.1	0.5	2.4	-0.1	-1.6	-0.1	-0.1	-0.1	-0.8	0.7
Bipolar Disorder (2011)	0.0	0.0	0.2	0.0	0.5	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.8	2.9	0.2	0.1	0.2	0.2	0.2	-1.7	1.6
Impedance of leg (left)	0.0	0.1	0.5	0.1	0.7	0.1	0.1	0.1	0.1	0.0
Diabetes (self-reported)	0.0	0.0	0.1	-0.2	-0.0	-0.2	-0.2	-0.2	-0.3	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.2	0.1	-0.4	0.1	0.1	0.1	-0.1	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	-0.2	0.1	-0.2	-0.2	-0.2	-0.1	0.1
Chest pain or discomfort	0.0	0.0	0.2	0.2	-0.2	0.2	0.2	0.2	-0.4	-0.0
Mood swings	0.0	0.1	0.2	-0.2	0.1	-0.2	-0.2	-0.2	0.5	0.0
Qualifications: nursing, teaching	0.0	0.1	0.3	0.1	-0.3	0.1	0.1	0.1	0.5	0.2
Tinnitus: Yes, now most or all of the time	0.0	0.1	0.2	-0.1	-0.3	-0.1	-0.1	-0.1	0.5	0.0

Hub : Genes

HSPG2

Models

Trait associations