Hub : Genes

IDH2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.6220	0.0440	0.0e+00	0.528	NA	0.546	NA	0.520	6.2e-41	NA	6.6e-43	NA	5.3e-40
2	GTEx	Skin Not Sun Exposed Suprapubic	0.2790	0.0720	2.4e-04	0.168	NA	0.129	NA	0.170	1.6e-09	NA	1.5e-07	NA	1.2e-09
3	GTEx	Skin Sun Exposed Lower leg	0.3310	0.0570	2.1e-10	0.235	NA	0.215	NA	0.053	2.2e-19	NA	1.1e-17	NA	3.2e-05
4	YFS	Blood	0.4033	0.0448	0.0e+00	0.031	0.150	0.184	0.175	0.125	1.4e-10	1.3e-46	5.1e-58	7.4e-55	9.9e-39
5	TCGA	Breast Invasive Carcinoma	0.1138	0.0373	0.0e+00	0.112	0.097	0.095	NA	0.107	5.3e-22	3.9e-19	7.2e-19	NA	3.7e-21
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0521	0.0209	2.7e-05	0.079	0.043	0.070	NA	0.076	3.5e-09	1.3e-05	2.5e-08	NA	6.3e-09
7	TCGA	Lung Squamous Cell Carcinoma	0.0731	0.0337	7.8e-05	0.029	0.046	0.030	NA	0.028	2.5e-04	5.2e-06	2.2e-04	NA	3.7e-04
8	TCGA	Prostate Adenocarcinoma	0.1951	0.0530	0.0e+00	0.231	0.196	0.223	NA	0.227	8.1e-24	3.8e-20	5.3e-23	NA	2.1e-23
9	TCGA	Uterine Corpus Endometrial Carcinoma	0.3160	0.1520	3.0e-03	0.037	0.074	0.099	NA	0.039	3.4e-02	4.2e-03	1.0e-03	NA	3.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.1	0.2	0.5	0.2	0.5	0.4	-0.3	0.2	-0.6	0.7	0.2	-0.2
Bipolar Disorder or Schizophrenia	0.5	1.2	4.0	1.1	1.2	1.2	0.4	0.6	-2.0	1.5	0.5	0.4
Depressed Affect (Nagel 2018)	0.4	0.8	2.1	-0.3	-0.5	-0.4	0.4	-1.1	-1.4	-1.4	-1.0	-0.4
Depression (Nagel 2018)	1.2	1.8	4.3	-1.3	-1.6	-1.6	0.4	-1.3	2.1	-1.1	-1.3	-0.6
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.4	-0.3	-0.1	-0.2	1.2	-0.5	-1.1	-1.0	-0.4	-0.8
Neuroticism (Nagel 2018)	0.3	0.6	2.1	-0.4	-0.7	-0.6	0.1	-1.1	-0.7	-1.5	-1.0	-0.2
Schizophrenia (2018)	0.7	1.4	4.2	1.2	1.2	1.2	0.8	0.6	-2.0	1.3	0.5	0.7
Schizophrenia vs Biploar Disorder	0.1	0.2	0.4	0.6	0.3	0.4	-0.1	0.3	-0.5	-0.7	0.3	0.3
Worry (Nagel 2018)	0.9	1.9	3.8	-1.3	-1.5	-1.5	-0.0	-1.7	0.7	-1.9	-1.8	-0.6
Alzheimer’s Disease (in mother)	0.7	0.8	1.5	-1.1	-0.9	-0.9	-1.2	-0.7	1.1	-0.4	-0.7	-0.9
Alzheimer’s Disease (in father)	6.0	6.5	8.4	-2.6	-2.8	-2.8	0.8	-2.8	1.8	-2.7	-2.8	-2.9
Alzheimer’s Disease (including proxy)	3.7	5.4	7.0	-2.7	-2.5	-2.5	-1.5	-2.6	1.4	-2.6	-2.5	-2.3
Crohns Disease (2017)	0.4	0.8	1.4	-1.0	-0.9	-1.1	-1.2	-0.9	0.9	-0.1	-0.9	-0.1
Irritable Bowel Disease (IBD)	0.2	0.4	2.7	-0.2	-0.3	-0.3	-1.7	-0.2	0.7	0.2	-0.3	0.1
Ulcerative Colitis (UC)	0.5	0.9	2.7	1.0	0.8	1.0	-1.6	0.9	-0.2	0.6	0.9	0.7
Major Depression (MDD)	0.3	0.4	1.0	-0.5	-0.6	-0.5	1.0	-0.3	0.9	0.1	-0.4	0.6
Reaction Time	0.5	0.9	1.5	1.1	1.0	0.9	0.2	1.1	-0.1	0.9	1.1	1.2
Verbal and Numeric Reasoning (VNR)	0.3	0.7	3.4	0.3	0.4	0.1	1.6	-0.2	-1.8	-0.4	-0.2	-0.2
Breast Cancer	0.3	0.7	4.5	0.4	0.8	0.7	0.7	0.3	-2.1	-0.1	0.5	0.2
Ovarian Cancer	2.1	2.8	5.5	1.4	1.7	1.5	0.8	1.9	-0.3	2.3	1.8	2.1
Prostate Cancer	1.0	1.3	5.3	1.3	1.3	1.3	-0.6	0.9	-2.3	-0.1	0.8	-0.2
Age at First Birth	0.6	0.9	2.0	1.0	0.8	0.8	0.5	1.0	0.1	1.2	1.1	1.4
Bipolar Disorder (2011)	2.1	2.0	3.6	-1.4	-1.2	-1.2	-1.0	-1.7	-0.7	-1.6	-1.7	-1.9
Body Mass Index (BMI) (2010)	0.5	0.7	1.7	-0.8	-0.8	-0.7	0.1	-1.1	-0.4	-0.3	-1.2	-1.3
Coronary Artery Disease (CAD)	0.3	0.4	1.0	0.3	0.6	0.6	-0.1	0.6	-0.6	1.0	0.8	-0.5
Crohns Disease (2012)	1.6	2.6	4.2	-1.7	-2.0	-2.0	-0.7	-2.0	1.5	-0.9	-1.9	-0.8
Mean Putamen Volume	0.1	0.1	0.4	-0.2	-0.3	-0.4	0.6	-0.3	0.3	0.2	-0.3	0.1
Fasting Glucose	0.2	0.2	0.6	-0.3	-0.3	-0.2	-0.1	0.0	0.7	-0.5	-0.1	-0.8
HbA1C	1.6	1.8	3.7	-1.5	-1.5	-1.5	-0.1	-1.9	-0.1	-1.3	-1.9	-0.7
HDL Cholesterol	0.2	0.3	0.9	-0.5	-0.3	-0.2	-0.6	-0.5	0.4	-0.3	-0.5	-0.9
LDL Cholesterol	0.2	0.3	0.8	0.6	0.2	0.1	0.7	0.5	0.4	0.9	0.3	0.8
Lupus	1.2	1.8	3.1	1.5	1.5	1.4	1.0	1.6	-0.8	0.9	1.8	1.4
Neuroticism (2016)	0.3	0.4	1.9	-0.2	-0.1	-0.2	-0.5	-0.3	-0.6	-1.4	-0.4	-0.7
Primary Biliary Cirrhosis	1.7	2.4	3.7	1.8	1.7	1.8	-1.1	1.9	-0.8	1.4	1.9	0.9
Rheumatoid Arthritis	0.2	0.2	1.3	-0.1	-0.2	0.0	-1.1	-0.3	-0.6	-0.4	-0.4	0.3
Schizophrenia (2014)	0.4	0.9	2.8	0.9	0.8	0.8	1.3	0.3	-1.7	0.7	0.3	0.6
Triglycerides	2.6	4.2	6.8	2.5	2.4	2.4	0.2	2.3	-2.6	0.7	2.2	1.5
Type 2 Diabetes (T2D) (2012)	1.0	1.1	4.3	-1.0	-1.2	-1.1	0.8	-0.8	2.1	-0.5	-0.7	0.2
Ulcerative Colitis	0.3	0.4	2.2	0.7	0.4	0.6	-1.5	0.5	-0.0	0.3	0.4	0.4
Blood Eosinophil Count	0.1	0.5	1.5	0.4	0.8	0.7	0.6	0.5	-1.2	-0.3	0.5	-0.6
Blood Platelet Count	0.2	1.9	3.0	1.0	1.7	1.7	0.8	1.7	-1.1	1.6	1.6	0.4
Blood Red Count	0.1	1.4	2.9	-1.3	-1.3	-1.3	-0.3	-1.1	1.1	-1.7	-1.2	-0.4
Blood White Count	1.9	13.8	21.1	4.5	4.3	4.6	1.9	4.2	-2.9	3.5	4.2	2.2
Heel T-Score	0.5	3.9	8.9	-2.0	-1.9	-3.0	-0.0	-1.9	0.8	-2.5	-2.1	-1.9
BMI	0.1	0.7	3.1	-0.6	-0.4	-0.5	1.8	-0.3	1.2	0.6	-0.2	-0.9
Height	0.3	6.5	22.8	-1.6	-2.8	-2.0	-0.6	-2.8	1.5	-4.8	-2.9	-1.7
Waist Hip Ratio (WHR)	0.6	2.7	4.9	2.1	1.9	1.9	-0.9	1.6	-2.2	0.1	1.5	1.6
Systolic Blood Pressure	2.3	11.7	20.1	3.7	3.8	4.0	-1.0	4.2	-1.9	1.6	4.0	4.5
Smoking Status	0.4	1.0	1.7	-0.8	-1.2	-1.3	-0.6	-1.1	0.9	-0.9	-1.1	-0.7
Allergy or Eczema	0.2	0.5	1.2	-0.9	-0.3	-0.9	0.3	-0.7	-1.1	-0.6	-0.7	0.1
Cardiovascular Disease	0.8	2.6	3.8	1.7	1.9	1.9	-1.1	1.6	-1.9	0.9	1.6	1.5
Hypothyroidism (self reported)	0.1	0.3	1.1	0.3	0.5	0.5	0.5	0.2	-1.1	-0.5	0.2	-0.2
Respiratory disease	1.4	3.0	6.2	2.0	2.1	2.1	0.3	1.7	-2.5	1.0	1.7	1.1
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.1	1.4	1.1	1.1	-1.4	1.4	0.4	0.5	1.4	0.8
Lung FEV1/FVC ratio	0.1	0.7	2.9	-1.0	-0.6	-0.6	0.8	-0.6	-0.1	-0.5	-0.7	-1.7
Lung FVC	0.5	2.4	3.8	-1.8	-1.7	-1.7	0.8	-1.9	0.8	-1.6	-1.9	-1.3
Neuroticism	0.7	1.7	8.3	-0.6	-0.8	-0.8	0.0	-1.4	-0.9	-2.9	-1.4	-0.7
Chronotype (morning person)	0.2	0.4	1.2	-0.7	-0.6	-0.7	0.1	-0.5	0.4	-1.1	-0.5	-0.2
Hair Pigment	0.1	2.4	5.4	-1.7	-1.6	-1.9	0.7	-2.3	-0.7	-0.9	-2.2	-0.5
Tanning	0.0	0.3	1.0	0.2	0.3	0.4	-0.0	0.3	-0.0	1.0	0.4	0.9
Hand grip strength (left)	0.0	0.1	0.3	-0.5	-0.5	-0.3	0.2	-0.4	0.3	0.2	-0.4	0.1
Number of treatments/medications taken	4.3	7.8	10.7	2.9	3.2	3.2	-0.8	3.3	-1.8	3.2	3.2	2.3
Average weekly spirits intake	0.1	0.1	0.5	0.2	-0.2	-0.1	-0.2	-0.0	0.7	0.4	0.0	-0.2
Sensitivity / hurt feelings	0.5	0.9	2.6	-0.9	-1.0	-1.0	0.2	-1.0	0.6	-1.6	-1.0	-0.7
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.7	-0.7	-0.9	-0.9	-0.1	-0.8	1.3	-1.1	-0.8	0.2
Hearing difficulty/problems: Yes	2.1	3.2	6.1	-2.5	-2.1	-2.0	0.4	-2.1	1.6	-0.5	-2.1	-1.7
Relative age of first facial hair	0.3	0.5	3.0	0.3	0.0	0.1	1.7	-0.3	-0.6	-0.9	-0.4	-0.6
Other serious medical condition/disability diagnosed by doctor	2.8	3.6	5.9	2.4	2.2	2.2	-0.3	2.1	-2.0	1.4	2.0	1.6
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.0	-1.0	-0.8	-0.7	-0.9	-0.9	0.7	0.1	-0.9	-0.3
Ever had hysterectomy (womb removed)	0.8	0.9	2.6	0.5	0.8	1.0	-1.6	1.1	0.1	1.0	1.0	0.7
Systolic blood pressure, automated reading	0.3	0.9	2.5	0.4	0.6	0.8	-1.6	1.0	0.5	-0.7	0.8	1.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	2.0	0.1	0.1	-0.0	-0.9	-0.2	-0.5	-1.0	-0.2	-1.4
Angina	0.2	0.3	2.0	-0.2	0.2	-0.0	0.2	0.1	-0.2	-0.7	0.1	-1.4
Medication for hormone replacement therapy	0.1	0.1	0.9	0.2	0.3	0.4	-0.2	0.1	-0.9	0.1	0.0	-0.1
Vitamin and mineral supplements	0.1	0.2	0.4	-0.5	-0.5	-0.6	-0.3	-0.4	0.5	-0.5	-0.4	0.2
Supplements: Zinc	3.5	3.8	8.2	1.9	2.1	2.2	0.1	2.0	-1.7	2.9	2.0	1.4
Medication: Co-codamol	0.2	0.2	0.7	0.5	0.5	0.6	0.8	0.3	-0.5	-0.2	0.2	0.4
Medication: Metformin	0.2	0.2	1.7	-0.1	0.1	0.0	-1.3	0.1	0.3	0.2	0.2	0.5
Diabetes (father)	1.0	1.3	4.8	0.6	0.9	1.0	-1.6	0.5	-2.2	0.4	0.5	1.1
Diabetes (mother)	0.3	0.4	2.1	0.3	0.3	0.3	-1.4	0.5	0.5	0.8	0.5	-0.1
Severe depression (siblings)	0.4	0.4	1.1	-0.6	-0.8	-0.8	0.6	-0.7	1.0	-0.2	-0.7	0.1
Pack years adult smoking proportion	0.2	0.3	0.8	0.6	0.6	0.7	-0.1	0.3	-0.9	-0.2	0.3	-0.7
Impedance of leg (right)	0.1	0.5	1.6	0.6	0.6	0.6	-0.7	0.7	0.1	0.2	0.7	1.3
Leg fat-free mass (left)	0.5	2.5	4.6	-1.6	-1.7	-1.5	-0.0	-1.9	0.8	-1.7	-1.9	-2.1
Trunk fat percentage	0.0	0.2	0.9	-0.1	0.2	0.2	-0.4	0.2	0.0	0.2	0.3	-1.0
Hand grip strength (right)	0.2	0.7	1.2	-0.9	-1.1	-0.8	0.6	-0.9	1.1	0.0	-0.9	-0.3
Townsend deprivation index at recruitment	0.2	0.3	1.2	-0.2	-0.1	-0.0	0.6	-0.4	-0.8	-1.1	-0.5	-0.1
Current tobacco smoking	0.4	0.7	1.0	0.8	0.8	0.8	-0.8	0.7	-0.9	1.0	0.8	0.6
Average weekly fortified wine intake	2.5	3.0	4.5	-1.7	-2.1	-2.1	0.8	-1.9	2.0	-1.3	-1.9	-1.1
Maternal smoking around birth	0.1	0.2	0.6	0.1	0.0	0.0	-0.7	0.0	0.1	0.8	0.1	-0.7
Fed-up feelings	1.1	2.0	5.2	-1.4	-1.3	-1.3	-0.3	-1.7	-0.3	-2.3	-1.6	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.0	-0.9	-0.8	-0.9	0.2	-0.8	1.0	-0.9	-0.8	-0.2
Relative age voice broke	0.7	1.1	3.5	-0.5	-0.8	-0.9	0.9	-1.2	-0.1	-1.9	-1.2	-1.0
Taking other prescription medications	1.8	2.8	4.1	1.7	2.0	1.9	-0.1	2.0	-1.0	2.0	2.0	1.4
Age when periods started (menarche)	0.4	1.0	5.1	0.2	-0.1	-0.0	1.3	-0.3	-0.8	-2.3	-0.4	-1.2
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.8	-1.2	-1.0	-0.9	-0.8	-1.3	0.3	-1.6	-1.3	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.9	-0.2	0.2	-0.2	0.0	-0.1	-1.4	-0.5	-0.1	-0.6
Tinnitus: Yes, but not now, but have in the past	3.1	3.3	4.6	-2.1	-1.9	-2.0	-0.1	-2.0	1.1	-1.9	-2.1	-2.0
Qualifications: CSEs or equivalent	0.1	0.2	0.8	-0.1	-0.3	-0.3	0.8	-0.1	0.9	0.2	-0.1	-0.1
Serious illness, injury or assault to yourself	1.0	1.2	4.5	1.2	1.2	1.2	-0.4	0.8	-2.1	-0.1	0.8	-0.7
High blood pressure	0.8	2.1	3.4	1.5	1.8	1.8	-1.4	1.8	-1.0	0.4	1.8	0.9
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.5	-1.5	-1.0	-1.6	0.6	-1.4	-0.5	-1.3	-1.3	-0.3
Multivitamins +/- minerals	0.1	0.1	0.3	0.2	0.3	0.4	0.0	0.4	0.1	0.4	0.4	0.5
Stomach or abdominal pain in last month	0.2	0.3	1.9	0.3	0.3	0.4	-0.3	0.4	0.1	1.4	0.4	0.1
Supplements: Glucosamine	1.4	1.9	3.5	1.9	1.6	1.6	-0.5	1.5	-1.3	1.1	1.5	0.9
Diverticular disease/diverticulitis (self-reported)	6.6	7.8	11.0	3.3	3.1	2.9	1.2	3.1	-2.0	2.7	3.0	3.1
Medication: Atenolol	0.6	0.7	4.6	-0.5	-0.2	-0.2	-2.2	-0.3	-0.2	-1.0	-0.2	-0.7
Medication: Levothyroxine sodium	1.5	2.5	4.8	1.8	1.8	2.0	0.5	1.6	-2.2	0.9	1.6	1.1
Sitting height	0.5	3.4	6.9	-1.9	-2.1	-1.8	-0.4	-2.3	0.4	-2.6	-2.4	-1.2
Chronic bronchitis/emphysema (father)	0.4	0.5	1.4	0.6	0.8	0.9	-0.4	0.7	-0.6	0.1	0.6	1.2
High blood pressure (mother)	0.7	1.0	2.4	0.9	0.9	0.9	1.3	1.0	-0.6	0.4	0.9	1.5
Body mass index (BMI)	0.1	0.5	2.5	-0.7	-0.5	-0.5	0.2	-0.5	0.4	-0.4	-0.5	-1.6
Impedance of leg (left)	0.2	1.1	2.9	0.9	1.0	1.0	-1.0	1.2	-0.1	0.7	1.2	1.7
Leg predicted mass (left)	0.4	2.4	4.2	-1.5	-1.7	-1.4	-0.0	-1.8	0.8	-1.6	-1.8	-2.0
Trunk fat mass	0.1	0.5	2.3	-0.7	-0.5	-0.4	-0.4	-0.6	0.4	-0.7	-0.5	-1.5
Waist circumference	0.4	1.5	3.1	-1.1	-1.2	-1.0	-1.0	-1.0	1.3	-1.3	-1.0	-1.8
Number of incorrect matches in round	1.3	2.2	3.8	-2.0	-1.5	-1.4	0.3	-1.6	1.3	-1.1	-1.5	-1.9
Past tobacco smoking	0.5	0.9	2.3	0.7	1.0	1.0	1.5	0.8	-1.1	0.9	0.8	0.2
Alcohol usually taken with meals	3.9	6.3	9.9	-2.6	-2.7	-2.5	-0.6	-2.5	1.9	-3.1	-2.6	-3.1
Nervous feelings	2.3	4.2	6.2	-2.3	-2.4	-2.4	0.0	-2.2	2.2	-2.5	-2.3	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	2.8	-1.6	-1.5	-1.6	-0.4	-1.7	0.8	-1.4	-1.6	-0.2
Hearing difficulty/problems with background noise	4.3	6.9	11.0	-3.3	-3.2	-3.1	-0.5	-3.1	2.2	-1.9	-3.1	-1.8
Hair/balding pattern: Pattern 2	0.3	0.4	1.8	0.1	-0.3	-0.3	1.3	-0.1	0.7	0.5	-0.1	0.7
Had menopause	0.6	0.8	3.0	0.5	0.7	0.6	0.3	0.6	-0.3	1.4	0.7	1.7
Had other major operations	2.1	2.5	4.0	1.7	2.0	2.0	0.1	1.8	-1.8	1.6	1.8	-0.1
Forced vital capacity (FVC)	0.4	1.6	3.0	-1.2	-1.5	-1.2	0.6	-1.7	0.6	-1.6	-1.7	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	3.1	0.4	0.5	0.2	0.8	0.2	-1.8	-0.2	0.1	-0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.5	0.6	0.8	0.7	1.2	0.6	-0.9	0.1	0.6	0.6
Qualifications: None of the above	0.1	0.1	0.6	-0.2	0.1	0.2	-0.8	-0.1	-0.1	-0.6	-0.1	-0.5
Financial difficulties in last 2 years	0.4	0.5	3.8	0.1	0.6	0.6	0.2	0.1	-2.0	0.2	0.2	-0.0
Mouth/teeth dental problems	0.5	0.7	1.8	1.3	0.9	1.1	0.6	0.8	-1.1	-0.2	0.7	-0.1
Heart attack	1.4	1.8	2.9	-1.3	-1.4	-1.5	-0.0	-1.2	1.7	-1.7	-1.1	-1.1
Allergy	0.4	0.9	1.9	1.3	0.9	1.4	-0.0	1.2	0.2	0.7	1.2	0.5
Pain all over the body in last month	0.3	0.3	0.9	0.7	0.5	0.3	0.9	0.5	0.1	0.5	0.5	0.1
Diabetes (self-reported)	1.2	1.8	2.9	1.5	1.5	1.6	-1.6	1.7	-0.4	0.6	1.7	0.7
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.8	0.6	1.1	0.8	-0.0	0.9	-1.7	0.7	0.9	0.5
Medication: Ramipril	4.5	5.7	9.8	2.4	2.9	2.9	-1.8	2.6	-3.1	1.4	2.6	0.8
Medication: Simvastatin	1.2	1.7	3.7	1.0	1.2	1.2	-0.2	1.5	-0.0	1.9	1.5	1.8
Fluid intelligence score	0.3	0.6	2.6	-0.2	0.1	-0.0	1.6	-0.3	-1.4	-0.6	-0.3	-0.8
Illnesses of siblings	1.2	1.7	3.6	-1.5	-1.7	-1.7	0.3	-1.4	1.9	-0.2	-1.3	-0.0
Neuroticism score	0.7	1.5	6.4	-0.9	-0.9	-0.9	-0.1	-1.4	-0.6	-2.5	-1.4	-0.6
Weight	0.4	2.0	4.5	-1.4	-1.5	-1.3	-0.2	-1.5	1.0	-1.6	-1.5	-2.1
Impedance of arm (right)	0.3	1.5	3.0	1.3	1.3	1.4	-0.7	1.2	-1.1	0.9	1.2	1.7
Arm fat percentage (right)	0.0	0.2	1.1	-0.1	0.1	0.2	-0.3	0.1	-0.3	0.1	0.2	-1.1
Trunk fat-free mass	1.0	5.6	9.5	-2.2	-2.7	-2.3	-0.0	-2.6	1.8	-3.1	-2.7	-2.5
Hip circumference	0.7	3.0	5.3	-1.7	-1.9	-1.8	0.4	-1.7	2.3	-1.3	-1.7	-2.0
Time employed in main current job	0.1	0.1	0.6	0.1	0.1	0.1	0.7	-0.1	-0.1	-0.8	-0.0	-0.4
Alcohol intake versus 10 years previously	0.0	0.0	0.1	0.4	0.2	-0.0	0.2	0.1	0.2	-0.2	-0.0	0.4
Father’s age at death	0.4	0.5	2.3	-0.1	-0.2	-0.2	0.8	-0.5	-1.0	-0.7	-0.4	-1.5
Worrier / anxious feelings	0.4	0.7	2.4	-0.5	-0.7	-0.8	0.8	-0.8	0.0	-1.5	-0.9	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	0.0	0.2	0.2	0.5	0.0	-0.5	-0.2	0.0	0.6
Falls in the last year	3.4	4.6	9.9	2.5	2.7	2.5	0.7	2.4	-3.1	0.2	2.4	0.4
Hair/balding pattern: Pattern 3	1.4	2.1	5.4	-1.6	-1.1	-1.3	0.1	-1.3	0.4	-2.3	-1.4	-2.1
Number of live births	0.1	0.2	1.3	0.5	0.3	0.3	-0.2	-0.0	-1.1	-0.1	-0.0	0.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	3.8	-1.5	-1.7	-1.4	0.9	-1.9	0.7	-1.8	-1.9	-1.1
Pulse rate	0.2	0.4	1.3	0.4	0.4	0.5	0.0	0.5	0.3	1.2	0.5	1.1
Happiness	0.3	0.4	0.8	-0.9	-0.8	-0.7	-0.2	-0.8	0.3	-0.5	-0.7	0.1
Noisy workplace	0.2	0.3	1.3	-0.2	0.3	0.3	-1.1	0.3	-0.4	-0.7	0.3	-0.3
Qualifications: A levels/AS levels or equivalent	2.0	4.5	8.8	2.6	2.5	2.4	0.2	2.1	-3.0	1.7	2.0	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	2.0	-0.2	-0.2	-0.4	1.4	-0.3	0.2	0.7	-0.2	-0.1
Mouth/teeth dental problems: Dentures	0.2	0.4	0.9	0.3	0.7	0.7	-0.9	0.6	-0.5	0.7	0.6	0.2
Asthma	0.6	1.2	4.3	1.0	1.2	1.2	-0.7	0.7	-2.1	0.9	0.8	0.3
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.6	3.8	-1.6	-1.7	-1.8	1.3	-1.8	1.0	-1.3	-1.8	-2.0
Medication: Cholesterol lowering	0.3	0.5	1.1	0.5	0.8	0.7	-0.5	1.0	0.1	0.4	1.1	0.7
Depression (self-reported)	0.6	0.8	1.3	0.9	1.0	1.1	-0.1	1.0	-0.6	0.6	0.9	1.1
Medication: Lansoprazole	1.8	2.0	3.2	1.3	1.5	1.6	-0.3	1.4	-1.3	1.8	1.5	1.6
Prospective memory result	0.2	0.2	0.9	0.1	-0.1	-0.3	-0.9	0.2	0.8	-0.3	0.2	-0.0
Lung cancer (father)	2.6	3.1	4.5	1.9	2.0	1.8	0.4	2.1	-1.0	1.7	2.1	1.9
Illnesses of mother	1.0	1.2	2.3	-1.1	-1.5	-1.5	0.6	-1.2	1.5	-0.3	-1.1	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.8	-0.8	-0.8	-0.6	1.0	-1.1	-0.5	-1.3	-1.1	-0.9
Pulse wave Arterial Stiffness index	0.3	0.4	0.9	0.9	0.4	0.4	0.2	0.8	0.5	-0.8	0.7	-0.1
Impedance of arm (left)	0.2	1.1	1.9	1.1	1.1	1.1	-0.4	1.0	-1.0	1.1	1.0	1.4
Arm fat mass (right)	0.2	0.6	2.7	-0.8	-0.7	-0.6	-0.3	-0.7	0.3	-0.6	-0.7	-1.7
Trunk predicted mass	1.0	5.6	9.4	-2.2	-2.7	-2.3	-0.1	-2.6	1.8	-3.1	-2.7	-2.5
Standing height	0.5	5.4	10.6	-1.9	-2.7	-2.1	-0.8	-2.7	1.7	-3.3	-2.8	-1.9
Length of working week for main job	0.7	0.7	2.2	0.8	0.6	0.4	-0.9	0.8	0.5	0.9	0.8	1.5
Exposure to tobacco smoke at home	0.6	0.7	1.6	0.6	1.0	1.1	-1.3	0.9	-0.5	0.2	1.0	-0.3
Breastfed as a baby	0.4	0.5	1.3	-0.7	-0.7	-0.7	0.3	-0.5	0.9	-1.1	-0.5	0.5
Tense / ‘highly strung’	1.2	2.1	3.5	-1.6	-1.7	-1.7	-0.5	-1.8	1.2	-1.3	-1.9	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.6	0.6	0.7	0.7	0.8	0.7	-0.7	0.4	0.6	-0.1
Hair/balding pattern: Pattern 4	0.7	1.8	2.9	-1.2	-1.3	-1.7	0.9	-1.4	0.3	-1.5	-1.4	-1.7
Birth weight of first child	0.6	1.2	2.3	-0.8	-1.0	-1.3	1.5	-1.1	0.6	-1.1	-1.1	-1.0
Peak expiratory flow (PEF)	0.5	1.0	2.1	-1.0	-0.9	-0.7	0.3	-1.3	-0.4	-1.4	-1.4	-1.1
Pulse wave reflection index	1.0	1.2	3.5	-0.6	-1.1	-1.1	0.7	-0.9	0.9	-1.9	-0.9	-1.4
Ever highly irritable/argumentative for 2 days	2.4	2.8	5.2	-2.0	-1.6	-1.8	0.2	-1.8	1.0	-1.8	-1.8	-2.3
Loud music exposure frequency	0.2	0.3	1.7	-0.0	-0.1	-0.2	-0.1	0.1	1.3	0.5	0.1	-0.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	6.3	0.1	0.3	0.4	-0.3	-0.2	-2.5	0.3	-0.2	0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	2.4	0.4	0.4	0.3	1.6	0.3	-0.7	1.1	0.4	0.7
Blood clot in the leg (DVT)	2.2	2.9	4.1	-1.9	-1.9	-2.0	-1.1	-2.0	1.5	-1.4	-2.0	-1.3
Medication: Paracetamol	0.8	1.4	2.6	-1.3	-1.0	-1.1	-0.4	-1.5	-0.4	-1.1	-1.5	-1.6
Headache pain in last month	0.6	1.1	3.0	-0.4	-0.8	-0.7	0.9	-1.1	-0.2	-1.7	-1.1	-1.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	2.4	-0.3	-0.6	-0.5	1.6	-0.8	-0.4	-0.4	-0.9	-0.4
Glaucoma (self-reported)	1.1	1.3	2.4	-1.2	-1.3	-1.3	-0.8	-1.1	1.5	-0.4	-1.1	-1.3
Gout (self-reported)	11.5	15.8	32.6	4.1	4.8	4.6	-1.3	3.9	-5.7	3.1	3.9	2.6
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	3.4	1.8	1.7	1.8	0.5	1.6	-1.5	0.7	1.6	1.6
Medication: Amlodipine	1.0	1.4	2.3	1.5	1.4	1.5	0.0	1.3	-1.5	-0.1	1.3	0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	-0.2	-0.5	-0.4	0.0	-0.3	0.7	0.1	-0.3	-0.1
Birth weight	1.2	2.6	5.0	-1.6	-1.9	-2.2	0.6	-1.7	2.1	-1.0	-1.7	-0.7
Chronic bronchitis/emphysema (mother)	1.9	2.2	5.5	1.5	1.7	1.8	-0.9	1.3	-2.3	0.8	1.4	1.2
High blood pressure (siblings)	0.4	0.5	2.0	0.4	0.8	0.8	-0.3	0.6	-1.4	-0.7	0.5	-0.4
Forced vital capacity (FVC), Best measure	0.3	1.2	2.2	-1.0	-1.2	-0.9	0.9	-1.5	-0.3	-1.4	-1.5	-0.7
Body fat percentage	0.1	0.2	1.4	-0.3	-0.0	-0.0	-0.5	-0.0	0.2	0.0	0.0	-1.2
Leg fat percentage (right)	0.1	0.3	1.5	-0.6	-0.3	-0.3	-0.5	-0.2	0.5	-0.3	-0.2	-1.2
Arm fat-free mass (right)	0.8	4.1	6.2	-2.0	-2.2	-2.0	0.1	-2.2	1.5	-2.5	-2.2	-2.2
Exposure to tobacco smoke outside home	2.8	3.7	4.8	2.0	2.2	2.2	-1.8	2.0	-2.1	1.5	2.1	1.0
Comparative body size at age 10	1.3	3.5	10.9	1.6	1.6	1.5	0.8	2.1	0.5	3.3	2.1	1.7
Number of full brothers	0.8	1.0	2.8	1.0	0.9	0.8	1.7	0.6	-1.3	0.4	0.6	1.2
Worry too long after embarrassment	0.2	0.3	0.9	0.6	0.5	0.5	0.2	0.5	-0.6	-0.9	0.5	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.2	-0.1	-0.0	0.0	-0.2	0.1	0.2	0.0	0.1	-0.4
Wheeze or whistling in the chest in last year	0.3	0.5	2.6	0.5	0.3	0.4	0.3	0.2	-0.6	-0.9	0.2	-1.6
Number of children fathered	0.7	0.8	2.1	0.8	0.7	0.7	-1.1	0.9	-0.4	1.5	0.9	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.4	-0.4	-0.3	-0.5	-0.3	0.8	-0.3	-0.2	-0.7
Age at first live birth	0.3	0.5	1.9	-0.7	-0.6	-0.6	1.4	-0.6	0.1	0.1	-0.5	-0.7
Pulse wave peak to peak time	0.5	0.5	1.3	-1.1	-0.7	-0.7	-0.3	-1.1	-0.2	0.4	-1.0	-0.1
Health satisfaction	0.3	0.4	1.0	-0.8	-0.5	-0.6	-0.8	-0.6	0.5	-1.0	-0.6	-0.3
Shortness of breath walking on level ground	0.6	0.7	2.0	0.4	0.6	0.7	-1.4	1.1	0.6	0.4	1.1	0.1
Qualifications: College or University degree	0.6	1.8	4.2	1.3	1.5	1.2	0.3	1.6	-0.9	2.1	1.6	0.5
Eye problems/disorders: None of the above	0.4	0.5	1.6	0.4	0.5	0.5	0.9	0.1	-1.3	0.4	0.1	1.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.3	-0.6	-0.5	-0.8	-0.3	-0.3	1.1	-0.6	-0.3	0.6
Emphysema/chronic bronchitis	0.5	0.6	1.0	0.9	0.9	1.0	-0.8	0.8	-0.4	0.8	0.9	0.3
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	0.6	0.5	0.6	0.5	0.7	-0.3	0.0	0.6	0.6
Neck or shoulder pain in last month	0.8	1.2	2.4	-1.4	-1.1	-1.0	0.5	-1.2	0.3	-1.6	-1.1	-1.2
Medication: Blood pressure	0.2	0.3	1.9	-0.0	0.4	0.3	-1.4	0.3	-0.3	-0.2	0.4	-0.2
Angina (self-reported)	0.2	0.2	1.5	-0.3	0.1	-0.2	0.2	0.1	0.1	-0.7	0.1	-1.2
Migraine (self-reported)	0.7	0.9	1.4	-1.0	-1.2	-1.0	-0.2	-1.1	1.1	-0.8	-1.1	-0.1
Medication: Ibuprofen	3.4	4.0	7.7	-2.0	-2.1	-2.1	1.0	-2.3	1.1	-1.7	-2.2	-2.8
Medication: Allopurinol	7.8	10.4	20.7	3.4	4.0	3.8	-0.5	3.3	-4.6	2.3	3.3	1.6
Medication: Omeprazole	0.6	0.7	1.5	0.9	0.7	0.7	0.0	1.0	0.4	0.9	1.0	1.2
Medication: Seretide 50 evohaler	0.9	1.0	1.9	-0.8	-1.0	-0.9	0.2	-1.2	0.1	-1.3	-1.1	-1.4
Mean time to correctly identify matches	0.4	0.8	1.3	1.1	0.9	0.8	-0.4	1.0	0.0	1.0	1.1	1.0
Heart disease (mother)	0.4	0.5	2.1	0.2	0.4	0.4	0.2	0.0	-1.2	-0.5	-0.0	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.6	1.1	1.1	1.3	-0.3	1.1	-0.9	1.0	1.1	0.4
Whole body fat mass	0.2	0.6	2.5	-0.8	-0.6	-0.5	-0.5	-0.7	0.5	-0.8	-0.6	-1.6
Leg fat mass (right)	0.2	0.7	2.8	-0.9	-0.7	-0.7	-0.3	-0.7	0.7	-0.5	-0.7	-1.7
Arm predicted mass (right)	0.7	3.7	5.9	-1.9	-2.2	-1.9	-0.1	-2.1	1.6	-2.4	-2.1	-2.1
Pulse rate, automated reading	0.1	0.4	2.8	-0.2	0.0	-0.0	-0.3	0.1	0.5	1.7	0.2	0.4
Alcohol intake frequency.	0.1	0.1	0.3	-0.3	-0.3	-0.5	-0.0	-0.6	0.1	-0.4	-0.6	-0.2
Comparative height size at age 10	0.2	1.1	2.6	-1.0	-1.3	-0.8	-0.6	-1.1	1.6	-1.0	-1.1	-0.0
Number of full sisters	0.8	1.0	2.1	1.1	1.2	1.1	0.1	1.0	-1.4	0.6	1.1	0.5
Suffer from ‘nerves’	2.3	3.6	5.6	-2.2	-2.2	-2.4	0.2	-2.2	1.8	-1.9	-2.2	-0.7
Overall health rating	0.3	0.7	1.1	1.1	0.9	0.9	-0.8	0.9	-0.5	-0.3	1.0	0.7
Chest pain or discomfort	1.0	1.4	7.7	-0.9	-0.9	-1.0	-0.0	-1.0	-0.3	-2.8	-1.1	-0.6
Had major operations	0.3	0.3	0.8	0.5	0.6	0.6	0.1	0.9	0.3	-0.4	0.8	-0.4
Age at last live birth	0.3	0.4	1.8	-0.5	-0.4	-0.3	0.7	-0.4	-0.3	-0.7	-0.4	-1.3
Family relationship satisfaction	0.1	0.1	0.2	-0.3	-0.3	-0.1	-0.5	-0.3	-0.0	-0.5	-0.2	0.1
Leg pain on walking	0.2	0.2	0.7	-0.3	-0.3	-0.4	0.2	-0.2	0.6	-0.9	-0.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.1	0.2	-0.2	-0.2	-0.0	-0.2	-0.3	-0.4	-0.1	-0.3	0.0
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.7	-0.9	-0.9	-1.1	1.0	-0.8	1.3	0.2	-0.7	-0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	0.1	0.1	0.2	-0.3	0.3	0.8	0.7	0.3	0.7
Medication: Aspirin	0.1	0.1	0.2	0.2	0.3	0.3	-0.5	0.3	-0.1	0.2	0.4	-0.4
Supplements: Vitamin C	0.5	0.6	3.6	-0.5	-0.3	-0.3	0.7	-0.4	0.2	-0.4	-0.3	-1.9
Knee pain experienced in last month	0.2	0.3	1.0	0.4	0.2	0.3	0.4	-0.1	-1.0	0.1	0.0	-0.9
Hypertension (Self-reported)	0.7	2.1	3.2	1.4	1.7	1.7	-1.8	1.7	-1.3	-0.0	1.6	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	3.0	0.5	0.6	0.8	-1.7	0.4	-1.3	1.2	0.4	0.9
Illnesses of father: Heart disease	0.2	0.2	1.4	-0.1	0.1	0.0	-1.2	0.2	0.4	0.2	0.3	0.5
Illnesses of siblings: Diabetes	0.9	1.1	1.8	1.2	1.0	1.2	-0.0	1.3	0.3	1.3	1.3	1.0
Smoking status: Previous	0.7	1.0	1.6	-1.0	-1.2	-1.3	-0.9	-1.1	1.0	-0.9	-1.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.3	0.8	0.6	0.9	-1.1	0.3	-1.5	0.2	0.3	0.3
Whole body fat-free mass	0.8	4.5	6.9	-2.0	-2.4	-2.1	-0.1	-2.4	1.4	-2.6	-2.4	-2.5
Leg fat-free mass (right)	0.3	1.8	3.5	-1.3	-1.5	-1.2	-0.0	-1.6	0.7	-1.4	-1.6	-1.9
Arm fat percentage (left)	0.0	0.1	1.1	-0.2	0.1	0.1	-0.2	0.0	-0.2	0.2	0.1	-1.1
Average weekly red wine intake	0.4	0.6	2.3	-0.5	-0.5	-0.5	-0.6	-0.3	0.7	-1.2	-0.3	-1.5
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.5	0.3	-0.1	-0.0	0.1	0.1	0.3	0.7	0.1	0.4
Mood swings	0.6	1.1	2.2	-1.0	-0.9	-0.8	0.2	-1.5	-0.5	-1.5	-1.4	-0.9
Loneliness, isolation	0.7	1.0	5.1	0.8	0.9	0.9	0.3	0.3	-2.3	-1.0	0.3	-0.3
Long-standing illness, disability or infirmity	0.2	0.3	1.4	0.5	0.5	0.5	-0.3	0.2	-1.2	-0.7	0.2	-0.1
Ever had bowel cancer screening	1.9	2.2	4.0	2.0	1.8	1.7	-0.6	2.0	-0.6	0.1	1.9	1.2
Diabetes diagnosed by doctor	1.1	1.8	2.9	1.6	1.6	1.6	-1.4	1.7	-0.6	0.6	1.7	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	3.3	-0.0	-0.0	0.1	-1.8	0.0	-0.3	0.4	0.1	-0.3
Friendships satisfaction	2.3	2.9	4.3	-2.1	-2.0	-2.0	-1.0	-1.9	1.8	-1.0	-2.0	-0.8
Qualifications: nursing, teaching	0.1	0.1	0.6	0.3	0.3	0.2	0.4	0.2	-0.2	0.8	0.2	0.5
Commuting to job workplace: Walk	0.2	0.3	1.0	0.5	0.5	0.6	0.5	0.3	-1.0	-0.0	0.3	-0.4
Eye problems/disorders: Cataract	0.1	0.1	0.9	0.2	-0.1	-0.0	-0.1	0.2	0.9	-0.2	0.2	0.1
Mouth/teeth dental problems: Mouth ulcers	3.0	4.7	8.1	-2.8	-2.5	-2.7	-0.4	-2.5	1.5	-1.7	-2.4	-1.9
Medication for cholesterol	0.2	0.3	0.8	-0.3	-0.5	-0.7	0.6	-0.4	0.6	-0.3	-0.4	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	3.6	-1.0	-0.7	-0.8	-1.9	-0.4	1.0	-0.1	-0.4	-0.4
Back pain experienced in last month	1.1	1.6	4.0	-1.1	-1.1	-1.0	-0.8	-1.3	-0.1	-2.0	-1.3	-1.6
Mineral and other dietary supplements	0.3	0.3	0.9	-1.0	-0.6	-0.8	0.2	-0.7	0.4	-0.4	-0.6	-0.1
Breast cancer (self-reported)	1.6	1.9	3.4	1.7	1.2	1.2	0.7	1.5	0.2	1.6	1.5	1.8
Asthma (self-reported)	0.9	1.9	5.7	1.4	1.6	1.6	-0.8	1.1	-2.4	1.1	1.2	0.2
Osteoporosis (self-reported)	0.9	1.1	2.7	1.4	1.0	1.2	1.7	0.8	-1.0	0.9	0.8	0.3
Osteoarthritis (self-reported)	1.3	1.7	3.4	1.4	1.7	1.7	-0.7	1.4	-1.8	0.6	1.3	0.0
Medication: Aspirin	0.1	0.1	0.2	0.1	0.3	0.3	-0.3	0.3	-0.1	0.4	0.3	-0.5
Medication: Gliclazide	2.6	2.9	4.3	2.0	2.0	2.0	-0.4	2.1	-1.3	1.5	2.1	1.3
Illnesses of father: None of the above (group 1)	0.2	0.2	1.3	-0.2	-0.4	-0.4	0.4	-0.4	0.2	0.1	-0.4	-1.1
Smoking status: Current	0.2	0.4	0.5	0.7	0.6	0.7	-0.7	0.6	-0.6	0.7	0.6	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.3	-1.0	-0.9	-0.9	1.0	-1.1	0.3	-1.0	-1.1	-0.5
Whole body water mass	0.8	4.4	6.9	-2.0	-2.4	-2.0	-0.0	-2.4	1.4	-2.6	-2.4	-2.5
Leg predicted mass (right)	0.4	2.0	3.7	-1.3	-1.5	-1.3	-0.0	-1.6	0.7	-1.5	-1.6	-1.9
Arm fat mass (left)	0.2	1.0	3.4	-1.0	-0.9	-0.8	-0.1	-1.0	0.4	-0.9	-0.9	-1.8
Number of self-reported non-cancer illnesses	1.2	2.2	3.4	1.8	1.9	1.9	-0.7	1.8	-1.3	1.0	1.8	-0.2
Average weekly champagne plus white wine intake	0.9	1.2	2.2	-1.1	-1.0	-1.1	-0.1	-0.8	1.3	-1.4	-0.9	-1.5
Miserableness	0.2	0.4	1.5	-0.3	-0.2	-0.2	0.6	-0.8	-1.2	-0.6	-0.8	-0.3
Guilty feelings	0.6	0.9	4.2	0.7	0.6	0.6	-2.1	0.5	-0.9	-0.2	0.5	1.1
Wears glasses or contact lenses	0.1	0.1	0.5	-0.2	-0.1	-0.1	-0.7	-0.0	0.0	-0.3	-0.0	0.5
Ever taken oral contraceptive pill	0.8	0.8	2.3	0.6	0.9	0.9	0.1	0.7	-1.5	1.5	0.7	0.1
Hearing aid user	0.2	0.2	0.5	0.5	0.5	0.5	-0.0	0.4	0.1	0.3	0.4	-0.7
Mother’s age at death	0.4	0.5	3.2	0.4	0.2	0.2	1.8	0.3	0.2	0.5	0.3	0.5
Financial situation satisfaction	0.2	0.2	0.5	-0.3	-0.3	-0.1	0.7	-0.4	-0.2	0.5	-0.4	-0.7
Tinnitus: Yes, now most or all of the time	0.2	0.2	1.2	0.0	-0.2	-0.0	-0.0	-0.1	0.4	1.1	-0.2	0.7
Commuting to job workplace: Public transport	0.3	0.4	1.2	0.4	0.5	0.6	-1.1	0.4	-1.0	-0.5	0.3	-0.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.5	-0.2	-0.1	-0.2	-0.4	-0.1	0.4	0.1	-0.1	-0.7
Medication: Blood pressure	2.1	4.0	6.3	2.2	2.3	2.5	-1.4	2.3	-1.9	1.0	2.2	1.6
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.1	-0.2	-0.1	-0.3	-0.1	-0.4	-0.5	-1.1	-0.3	-0.2
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.5	0.2	0.0	0.1	0.5	0.0	0.1	-0.7	-0.0	-0.5
High cholesterol (Self-reported)	0.2	0.3	0.8	0.2	0.3	0.4	-0.9	0.6	0.0	0.5	0.6	0.7
Medication: Bendroflumethiazide	1.8	2.7	3.8	1.6	1.8	1.9	-0.8	1.5	-1.8	1.7	1.5	1.9
Medication: Paracetamol	0.6	1.0	2.3	-1.1	-0.7	-0.8	-0.8	-1.2	-0.3	-0.9	-1.1	-1.5
Medication: Lisinopril	0.3	0.4	0.7	0.8	0.7	0.8	0.1	0.8	-0.7	0.3	0.8	0.6
Medication: Atorvastatin	0.3	0.3	1.5	0.1	0.1	-0.0	-0.4	0.4	1.2	-0.2	0.5	0.8
Illnesses of father: High blood pressure	0.8	1.0	1.7	-1.1	-0.6	-0.7	-0.3	-1.2	-1.1	-1.3	-1.1	-0.9
Alcohol drinker status: Never	0.1	0.2	0.3	-0.3	-0.3	-0.5	-0.2	-0.6	0.3	0.0	-0.6	-0.5
Ever smoked	0.3	0.5	2.9	-0.2	-0.3	-0.3	-1.7	-0.1	0.6	-0.5	-0.0	0.5
Basal metabolic rate	0.7	3.7	5.8	-1.8	-2.1	-1.8	-0.0	-2.2	1.3	-2.3	-2.2	-2.4
Leg fat percentage (left)	0.1	0.2	1.3	-0.4	-0.1	-0.2	-0.6	-0.0	0.3	-0.2	0.0	-1.1
Arm fat-free mass (left)	0.7	3.6	5.1	-1.8	-2.1	-1.9	0.1	-2.1	1.5	-2.3	-2.1	-2.1
Number of operations (self-reported)	0.7	1.0	1.9	0.9	1.1	1.1	-0.1	1.4	0.1	0.9	1.4	-0.9
Average weekly beer plus cider intake	0.1	0.2	0.6	0.2	0.4	0.3	0.5	0.3	-0.4	0.8	0.4	0.6
Irritability	0.3	0.5	1.1	-0.8	-0.6	-0.6	0.0	-1.0	-0.5	-0.8	-1.1	0.3
Risk taking	0.3	0.5	2.0	-0.2	0.0	-0.0	0.3	-0.2	-1.1	-0.8	-0.2	-1.4
Ever had prostate specific antigen (PSA) test	1.2	1.4	2.5	1.5	1.1	1.4	-1.4	1.5	-0.3	0.2	1.6	0.5
Fractured/broken bones in last 5 years	0.6	0.7	3.2	0.5	0.3	0.6	0.8	0.1	-1.3	-0.4	0.1	-1.8
Age started oral contraceptive pill	1.2	1.5	2.7	1.6	1.5	1.4	-0.0	1.5	-1.1	0.7	1.4	0.9
Diastolic blood pressure, automated reading	0.5	1.5	3.5	-1.4	-1.3	-1.1	0.0	-0.8	1.8	-1.9	-0.9	-0.6
Ever depressed for a whole week	0.0	0.0	0.2	-0.3	-0.1	-0.2	-0.0	-0.1	0.1	0.4	-0.1	-0.0
Unable to work because of sickness or disability	1.3	1.7	2.6	1.1	1.5	1.4	-0.1	1.6	-0.8	1.6	1.6	1.3
Commuting to job workplace: Cycle	0.6	0.7	1.4	1.0	0.9	0.9	-0.2	1.1	-0.2	1.0	1.2	0.3
Myopia	0.2	0.3	1.1	0.3	0.4	0.3	0.3	0.2	-0.9	0.2	0.2	-1.0
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.0	-1.0	-1.2	-1.2	1.4	-1.4	0.5	0.1	-1.4	-0.4
Cholesterol lowering medication	0.4	0.6	2.8	-0.5	-0.6	-0.5	0.2	-0.1	1.7	0.8	-0.2	1.0
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.5	1.1	0.8	0.9	-0.4	1.1	0.3	1.2	1.1	1.6
Pain experienced in last month	0.8	1.3	3.3	1.1	1.1	1.1	-0.2	1.3	-0.4	1.2	1.2	1.8
Supplements: Calcium	2.9	3.1	5.1	2.0	1.8	2.0	-0.2	1.7	-1.4	2.0	1.7	2.2
Basal cell carcinoma (self-reported)	0.4	0.5	2.0	0.1	0.3	0.4	-0.3	-0.2	-1.4	0.6	-0.1	-1.2
Heart attack/myocardial infarction (self-reported)	1.5	1.9	2.9	-1.4	-1.5	-1.5	-0.0	-1.3	1.7	-1.7	-1.2	-1.3
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	3.1	-1.6	-1.6	-1.7	-1.0	-1.7	1.3	-1.1	-1.8	-1.0
Heart disease (siblings)	0.5	0.7	2.2	-0.4	-0.4	-0.5	-0.1	-1.0	-0.6	-1.5	-1.0	-0.9
Alcohol drinker status: Previous	0.4	0.4	1.0	-0.5	-0.8	-0.8	-0.8	-0.6	1.0	0.1	-0.6	-0.1
Pack years of smoking	0.2	0.2	0.9	0.4	0.4	0.5	-0.2	0.2	-0.6	-0.5	0.2	-0.9
Impedance of whole body	0.4	2.0	3.8	1.5	1.5	1.5	-0.7	1.5	-0.9	1.2	1.5	2.0
Leg fat mass (left)	0.2	0.6	2.5	-0.9	-0.7	-0.7	-0.4	-0.7	0.6	-0.5	-0.6	-1.6
Arm predicted mass (left)	0.6	3.1	4.6	-1.7	-2.0	-1.7	0.2	-2.0	1.4	-2.1	-2.0	-1.9