Hub : Genes

IDH2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.6220 0.0440 0.0e+00 0.528 NA 0.546 NA 0.520 6.2e-41 NA 6.6e-43 NA 5.3e-40
2 GTEx Skin Not Sun Exposed Suprapubic 0.2790 0.0720 2.4e-04 0.168 NA 0.129 NA 0.170 1.6e-09 NA 1.5e-07 NA 1.2e-09
3 GTEx Skin Sun Exposed Lower leg 0.3310 0.0570 2.1e-10 0.235 NA 0.215 NA 0.053 2.2e-19 NA 1.1e-17 NA 3.2e-05
4 YFS Blood 0.4033 0.0448 0.0e+00 0.031 0.150 0.184 0.175 0.125 1.4e-10 1.3e-46 5.1e-58 7.4e-55 9.9e-39
5 TCGA Breast Invasive Carcinoma 0.1138 0.0373 0.0e+00 0.112 0.097 0.095 NA 0.107 5.3e-22 3.9e-19 7.2e-19 NA 3.7e-21
6 TCGA Kidney Renal Clear Cell Carcinoma 0.0521 0.0209 2.7e-05 0.079 0.043 0.070 NA 0.076 3.5e-09 1.3e-05 2.5e-08 NA 6.3e-09
7 TCGA Lung Squamous Cell Carcinoma 0.0731 0.0337 7.8e-05 0.029 0.046 0.030 NA 0.028 2.5e-04 5.2e-06 2.2e-04 NA 3.7e-04
8 TCGA Prostate Adenocarcinoma 0.1951 0.0530 0.0e+00 0.231 0.196 0.223 NA 0.227 8.1e-24 3.8e-20 5.3e-23 NA 2.1e-23
9 TCGA Uterine Corpus Endometrial Carcinoma 0.3160 0.1520 3.0e-03 0.037 0.074 0.099 NA 0.039 3.4e-02 4.2e-03 1.0e-03 NA 3.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.1 0.2 0.5 0.2 0.5 0.4 -0.3 0.2 -0.6 0.7 0.2 -0.2
Bipolar Disorder or Schizophrenia 0.5 1.2 4.0 1.1 1.2 1.2 0.4 0.6 -2.0 1.5 0.5 0.4
Depressed Affect (Nagel 2018) 0.4 0.8 2.1 -0.3 -0.5 -0.4 0.4 -1.1 -1.4 -1.4 -1.0 -0.4
Depression (Nagel 2018) 1.2 1.8 4.3 -1.3 -1.6 -1.6 0.4 -1.3 2.1 -1.1 -1.3 -0.6
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.4 -0.3 -0.1 -0.2 1.2 -0.5 -1.1 -1.0 -0.4 -0.8
Neuroticism (Nagel 2018) 0.3 0.6 2.1 -0.4 -0.7 -0.6 0.1 -1.1 -0.7 -1.5 -1.0 -0.2
Schizophrenia (2018) 0.7 1.4 4.2 1.2 1.2 1.2 0.8 0.6 -2.0 1.3 0.5 0.7
Schizophrenia vs Biploar Disorder 0.1 0.2 0.4 0.6 0.3 0.4 -0.1 0.3 -0.5 -0.7 0.3 0.3
Worry (Nagel 2018) 0.9 1.9 3.8 -1.3 -1.5 -1.5 -0.0 -1.7 0.7 -1.9 -1.8 -0.6
Alzheimer’s Disease (in mother) 0.7 0.8 1.5 -1.1 -0.9 -0.9 -1.2 -0.7 1.1 -0.4 -0.7 -0.9
Alzheimer’s Disease (in father) 6.0 6.5 8.4 -2.6 -2.8 -2.8 0.8 -2.8 1.8 -2.7 -2.8 -2.9
Alzheimer’s Disease (including proxy) 3.7 5.4 7.0 -2.7 -2.5 -2.5 -1.5 -2.6 1.4 -2.6 -2.5 -2.3
Crohns Disease (2017) 0.4 0.8 1.4 -1.0 -0.9 -1.1 -1.2 -0.9 0.9 -0.1 -0.9 -0.1
Irritable Bowel Disease (IBD) 0.2 0.4 2.7 -0.2 -0.3 -0.3 -1.7 -0.2 0.7 0.2 -0.3 0.1
Ulcerative Colitis (UC) 0.5 0.9 2.7 1.0 0.8 1.0 -1.6 0.9 -0.2 0.6 0.9 0.7
Major Depression (MDD) 0.3 0.4 1.0 -0.5 -0.6 -0.5 1.0 -0.3 0.9 0.1 -0.4 0.6
Reaction Time 0.5 0.9 1.5 1.1 1.0 0.9 0.2 1.1 -0.1 0.9 1.1 1.2
Verbal and Numeric Reasoning (VNR) 0.3 0.7 3.4 0.3 0.4 0.1 1.6 -0.2 -1.8 -0.4 -0.2 -0.2
Breast Cancer 0.3 0.7 4.5 0.4 0.8 0.7 0.7 0.3 -2.1 -0.1 0.5 0.2
Ovarian Cancer 2.1 2.8 5.5 1.4 1.7 1.5 0.8 1.9 -0.3 2.3 1.8 2.1
Prostate Cancer 1.0 1.3 5.3 1.3 1.3 1.3 -0.6 0.9 -2.3 -0.1 0.8 -0.2
Age at First Birth 0.6 0.9 2.0 1.0 0.8 0.8 0.5 1.0 0.1 1.2 1.1 1.4
Bipolar Disorder (2011) 2.1 2.0 3.6 -1.4 -1.2 -1.2 -1.0 -1.7 -0.7 -1.6 -1.7 -1.9
Body Mass Index (BMI) (2010) 0.5 0.7 1.7 -0.8 -0.8 -0.7 0.1 -1.1 -0.4 -0.3 -1.2 -1.3
Coronary Artery Disease (CAD) 0.3 0.4 1.0 0.3 0.6 0.6 -0.1 0.6 -0.6 1.0 0.8 -0.5
Crohns Disease (2012) 1.6 2.6 4.2 -1.7 -2.0 -2.0 -0.7 -2.0 1.5 -0.9 -1.9 -0.8
Mean Putamen Volume 0.1 0.1 0.4 -0.2 -0.3 -0.4 0.6 -0.3 0.3 0.2 -0.3 0.1
Fasting Glucose 0.2 0.2 0.6 -0.3 -0.3 -0.2 -0.1 0.0 0.7 -0.5 -0.1 -0.8
HbA1C 1.6 1.8 3.7 -1.5 -1.5 -1.5 -0.1 -1.9 -0.1 -1.3 -1.9 -0.7
HDL Cholesterol 0.2 0.3 0.9 -0.5 -0.3 -0.2 -0.6 -0.5 0.4 -0.3 -0.5 -0.9
LDL Cholesterol 0.2 0.3 0.8 0.6 0.2 0.1 0.7 0.5 0.4 0.9 0.3 0.8
Lupus 1.2 1.8 3.1 1.5 1.5 1.4 1.0 1.6 -0.8 0.9 1.8 1.4
Neuroticism (2016) 0.3 0.4 1.9 -0.2 -0.1 -0.2 -0.5 -0.3 -0.6 -1.4 -0.4 -0.7
Primary Biliary Cirrhosis 1.7 2.4 3.7 1.8 1.7 1.8 -1.1 1.9 -0.8 1.4 1.9 0.9
Rheumatoid Arthritis 0.2 0.2 1.3 -0.1 -0.2 0.0 -1.1 -0.3 -0.6 -0.4 -0.4 0.3
Schizophrenia (2014) 0.4 0.9 2.8 0.9 0.8 0.8 1.3 0.3 -1.7 0.7 0.3 0.6
Triglycerides 2.6 4.2 6.8 2.5 2.4 2.4 0.2 2.3 -2.6 0.7 2.2 1.5
Type 2 Diabetes (T2D) (2012) 1.0 1.1 4.3 -1.0 -1.2 -1.1 0.8 -0.8 2.1 -0.5 -0.7 0.2
Ulcerative Colitis 0.3 0.4 2.2 0.7 0.4 0.6 -1.5 0.5 -0.0 0.3 0.4 0.4
Blood Eosinophil Count 0.1 0.5 1.5 0.4 0.8 0.7 0.6 0.5 -1.2 -0.3 0.5 -0.6
Blood Platelet Count 0.2 1.9 3.0 1.0 1.7 1.7 0.8 1.7 -1.1 1.6 1.6 0.4
Blood Red Count 0.1 1.4 2.9 -1.3 -1.3 -1.3 -0.3 -1.1 1.1 -1.7 -1.2 -0.4
Blood White Count 1.9 13.8 21.1 4.5 4.3 4.6 1.9 4.2 -2.9 3.5 4.2 2.2
Heel T-Score 0.5 3.9 8.9 -2.0 -1.9 -3.0 -0.0 -1.9 0.8 -2.5 -2.1 -1.9
BMI 0.1 0.7 3.1 -0.6 -0.4 -0.5 1.8 -0.3 1.2 0.6 -0.2 -0.9
Height 0.3 6.5 22.8 -1.6 -2.8 -2.0 -0.6 -2.8 1.5 -4.8 -2.9 -1.7
Waist Hip Ratio (WHR) 0.6 2.7 4.9 2.1 1.9 1.9 -0.9 1.6 -2.2 0.1 1.5 1.6
Systolic Blood Pressure 2.3 11.7 20.1 3.7 3.8 4.0 -1.0 4.2 -1.9 1.6 4.0 4.5
Smoking Status 0.4 1.0 1.7 -0.8 -1.2 -1.3 -0.6 -1.1 0.9 -0.9 -1.1 -0.7
Allergy or Eczema 0.2 0.5 1.2 -0.9 -0.3 -0.9 0.3 -0.7 -1.1 -0.6 -0.7 0.1
Cardiovascular Disease 0.8 2.6 3.8 1.7 1.9 1.9 -1.1 1.6 -1.9 0.9 1.6 1.5
Hypothyroidism (self reported) 0.1 0.3 1.1 0.3 0.5 0.5 0.5 0.2 -1.1 -0.5 0.2 -0.2
Respiratory disease 1.4 3.0 6.2 2.0 2.1 2.1 0.3 1.7 -2.5 1.0 1.7 1.1
Type 2 Diabetes (T2D) (2018) 0.7 1.3 2.1 1.4 1.1 1.1 -1.4 1.4 0.4 0.5 1.4 0.8
Lung FEV1/FVC ratio 0.1 0.7 2.9 -1.0 -0.6 -0.6 0.8 -0.6 -0.1 -0.5 -0.7 -1.7
Lung FVC 0.5 2.4 3.8 -1.8 -1.7 -1.7 0.8 -1.9 0.8 -1.6 -1.9 -1.3
Neuroticism 0.7 1.7 8.3 -0.6 -0.8 -0.8 0.0 -1.4 -0.9 -2.9 -1.4 -0.7
Chronotype (morning person) 0.2 0.4 1.2 -0.7 -0.6 -0.7 0.1 -0.5 0.4 -1.1 -0.5 -0.2
Hair Pigment 0.1 2.4 5.4 -1.7 -1.6 -1.9 0.7 -2.3 -0.7 -0.9 -2.2 -0.5
Tanning 0.0 0.3 1.0 0.2 0.3 0.4 -0.0 0.3 -0.0 1.0 0.4 0.9
Hand grip strength (left) 0.0 0.1 0.3 -0.5 -0.5 -0.3 0.2 -0.4 0.3 0.2 -0.4 0.1
Number of treatments/medications taken 4.3 7.8 10.7 2.9 3.2 3.2 -0.8 3.3 -1.8 3.2 3.2 2.3
Average weekly spirits intake 0.1 0.1 0.5 0.2 -0.2 -0.1 -0.2 -0.0 0.7 0.4 0.0 -0.2
Sensitivity / hurt feelings 0.5 0.9 2.6 -0.9 -1.0 -1.0 0.2 -1.0 0.6 -1.6 -1.0 -0.7
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.7 -0.7 -0.9 -0.9 -0.1 -0.8 1.3 -1.1 -0.8 0.2
Hearing difficulty/problems: Yes 2.1 3.2 6.1 -2.5 -2.1 -2.0 0.4 -2.1 1.6 -0.5 -2.1 -1.7
Relative age of first facial hair 0.3 0.5 3.0 0.3 0.0 0.1 1.7 -0.3 -0.6 -0.9 -0.4 -0.6
Other serious medical condition/disability diagnosed by doctor 2.8 3.6 5.9 2.4 2.2 2.2 -0.3 2.1 -2.0 1.4 2.0 1.6
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.0 -1.0 -0.8 -0.7 -0.9 -0.9 0.7 0.1 -0.9 -0.3
Ever had hysterectomy (womb removed) 0.8 0.9 2.6 0.5 0.8 1.0 -1.6 1.1 0.1 1.0 1.0 0.7
Systolic blood pressure, automated reading 0.3 0.9 2.5 0.4 0.6 0.8 -1.6 1.0 0.5 -0.7 0.8 1.4
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 2.0 0.1 0.1 -0.0 -0.9 -0.2 -0.5 -1.0 -0.2 -1.4
Angina 0.2 0.3 2.0 -0.2 0.2 -0.0 0.2 0.1 -0.2 -0.7 0.1 -1.4
Medication for hormone replacement therapy 0.1 0.1 0.9 0.2 0.3 0.4 -0.2 0.1 -0.9 0.1 0.0 -0.1
Vitamin and mineral supplements 0.1 0.2 0.4 -0.5 -0.5 -0.6 -0.3 -0.4 0.5 -0.5 -0.4 0.2
Supplements: Zinc 3.5 3.8 8.2 1.9 2.1 2.2 0.1 2.0 -1.7 2.9 2.0 1.4
Medication: Co-codamol 0.2 0.2 0.7 0.5 0.5 0.6 0.8 0.3 -0.5 -0.2 0.2 0.4
Medication: Metformin 0.2 0.2 1.7 -0.1 0.1 0.0 -1.3 0.1 0.3 0.2 0.2 0.5
Diabetes (father) 1.0 1.3 4.8 0.6 0.9 1.0 -1.6 0.5 -2.2 0.4 0.5 1.1
Diabetes (mother) 0.3 0.4 2.1 0.3 0.3 0.3 -1.4 0.5 0.5 0.8 0.5 -0.1
Severe depression (siblings) 0.4 0.4 1.1 -0.6 -0.8 -0.8 0.6 -0.7 1.0 -0.2 -0.7 0.1
Pack years adult smoking proportion 0.2 0.3 0.8 0.6 0.6 0.7 -0.1 0.3 -0.9 -0.2 0.3 -0.7
Impedance of leg (right) 0.1 0.5 1.6 0.6 0.6 0.6 -0.7 0.7 0.1 0.2 0.7 1.3
Leg fat-free mass (left) 0.5 2.5 4.6 -1.6 -1.7 -1.5 -0.0 -1.9 0.8 -1.7 -1.9 -2.1
Trunk fat percentage 0.0 0.2 0.9 -0.1 0.2 0.2 -0.4 0.2 0.0 0.2 0.3 -1.0
Hand grip strength (right) 0.2 0.7 1.2 -0.9 -1.1 -0.8 0.6 -0.9 1.1 0.0 -0.9 -0.3
Townsend deprivation index at recruitment 0.2 0.3 1.2 -0.2 -0.1 -0.0 0.6 -0.4 -0.8 -1.1 -0.5 -0.1
Current tobacco smoking 0.4 0.7 1.0 0.8 0.8 0.8 -0.8 0.7 -0.9 1.0 0.8 0.6
Average weekly fortified wine intake 2.5 3.0 4.5 -1.7 -2.1 -2.1 0.8 -1.9 2.0 -1.3 -1.9 -1.1
Maternal smoking around birth 0.1 0.2 0.6 0.1 0.0 0.0 -0.7 0.0 0.1 0.8 0.1 -0.7
Fed-up feelings 1.1 2.0 5.2 -1.4 -1.3 -1.3 -0.3 -1.7 -0.3 -2.3 -1.6 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.0 -0.9 -0.8 -0.9 0.2 -0.8 1.0 -0.9 -0.8 -0.2
Relative age voice broke 0.7 1.1 3.5 -0.5 -0.8 -0.9 0.9 -1.2 -0.1 -1.9 -1.2 -1.0
Taking other prescription medications 1.8 2.8 4.1 1.7 2.0 1.9 -0.1 2.0 -1.0 2.0 2.0 1.4
Age when periods started (menarche) 0.4 1.0 5.1 0.2 -0.1 -0.0 1.3 -0.3 -0.8 -2.3 -0.4 -1.2
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 2.8 -1.2 -1.0 -0.9 -0.8 -1.3 0.3 -1.6 -1.3 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 1.9 -0.2 0.2 -0.2 0.0 -0.1 -1.4 -0.5 -0.1 -0.6
Tinnitus: Yes, but not now, but have in the past 3.1 3.3 4.6 -2.1 -1.9 -2.0 -0.1 -2.0 1.1 -1.9 -2.1 -2.0
Qualifications: CSEs or equivalent 0.1 0.2 0.8 -0.1 -0.3 -0.3 0.8 -0.1 0.9 0.2 -0.1 -0.1
Serious illness, injury or assault to yourself 1.0 1.2 4.5 1.2 1.2 1.2 -0.4 0.8 -2.1 -0.1 0.8 -0.7
High blood pressure 0.8 2.1 3.4 1.5 1.8 1.8 -1.4 1.8 -1.0 0.4 1.8 0.9
Hayfever, allergic rhinitis or eczema 0.6 1.3 2.5 -1.5 -1.0 -1.6 0.6 -1.4 -0.5 -1.3 -1.3 -0.3
Multivitamins +/- minerals 0.1 0.1 0.3 0.2 0.3 0.4 0.0 0.4 0.1 0.4 0.4 0.5
Stomach or abdominal pain in last month 0.2 0.3 1.9 0.3 0.3 0.4 -0.3 0.4 0.1 1.4 0.4 0.1
Supplements: Glucosamine 1.4 1.9 3.5 1.9 1.6 1.6 -0.5 1.5 -1.3 1.1 1.5 0.9
Diverticular disease/diverticulitis (self-reported) 6.6 7.8 11.0 3.3 3.1 2.9 1.2 3.1 -2.0 2.7 3.0 3.1
Medication: Atenolol 0.6 0.7 4.6 -0.5 -0.2 -0.2 -2.2 -0.3 -0.2 -1.0 -0.2 -0.7
Medication: Levothyroxine sodium 1.5 2.5 4.8 1.8 1.8 2.0 0.5 1.6 -2.2 0.9 1.6 1.1
Sitting height 0.5 3.4 6.9 -1.9 -2.1 -1.8 -0.4 -2.3 0.4 -2.6 -2.4 -1.2
Chronic bronchitis/emphysema (father) 0.4 0.5 1.4 0.6 0.8 0.9 -0.4 0.7 -0.6 0.1 0.6 1.2
High blood pressure (mother) 0.7 1.0 2.4 0.9 0.9 0.9 1.3 1.0 -0.6 0.4 0.9 1.5
Body mass index (BMI) 0.1 0.5 2.5 -0.7 -0.5 -0.5 0.2 -0.5 0.4 -0.4 -0.5 -1.6
Impedance of leg (left) 0.2 1.1 2.9 0.9 1.0 1.0 -1.0 1.2 -0.1 0.7 1.2 1.7
Leg predicted mass (left) 0.4 2.4 4.2 -1.5 -1.7 -1.4 -0.0 -1.8 0.8 -1.6 -1.8 -2.0
Trunk fat mass 0.1 0.5 2.3 -0.7 -0.5 -0.4 -0.4 -0.6 0.4 -0.7 -0.5 -1.5
Waist circumference 0.4 1.5 3.1 -1.1 -1.2 -1.0 -1.0 -1.0 1.3 -1.3 -1.0 -1.8
Number of incorrect matches in round 1.3 2.2 3.8 -2.0 -1.5 -1.4 0.3 -1.6 1.3 -1.1 -1.5 -1.9
Past tobacco smoking 0.5 0.9 2.3 0.7 1.0 1.0 1.5 0.8 -1.1 0.9 0.8 0.2
Alcohol usually taken with meals 3.9 6.3 9.9 -2.6 -2.7 -2.5 -0.6 -2.5 1.9 -3.1 -2.6 -3.1
Nervous feelings 2.3 4.2 6.2 -2.3 -2.4 -2.4 0.0 -2.2 2.2 -2.5 -2.3 -0.3
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 2.8 -1.6 -1.5 -1.6 -0.4 -1.7 0.8 -1.4 -1.6 -0.2
Hearing difficulty/problems with background noise 4.3 6.9 11.0 -3.3 -3.2 -3.1 -0.5 -3.1 2.2 -1.9 -3.1 -1.8
Hair/balding pattern: Pattern 2 0.3 0.4 1.8 0.1 -0.3 -0.3 1.3 -0.1 0.7 0.5 -0.1 0.7
Had menopause 0.6 0.8 3.0 0.5 0.7 0.6 0.3 0.6 -0.3 1.4 0.7 1.7
Had other major operations 2.1 2.5 4.0 1.7 2.0 2.0 0.1 1.8 -1.8 1.6 1.8 -0.1
Forced vital capacity (FVC) 0.4 1.6 3.0 -1.2 -1.5 -1.2 0.6 -1.7 0.6 -1.6 -1.7 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 3.1 0.4 0.5 0.2 0.8 0.2 -1.8 -0.2 0.1 -0.7
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.5 0.6 0.8 0.7 1.2 0.6 -0.9 0.1 0.6 0.6
Qualifications: None of the above 0.1 0.1 0.6 -0.2 0.1 0.2 -0.8 -0.1 -0.1 -0.6 -0.1 -0.5
Financial difficulties in last 2 years 0.4 0.5 3.8 0.1 0.6 0.6 0.2 0.1 -2.0 0.2 0.2 -0.0
Mouth/teeth dental problems 0.5 0.7 1.8 1.3 0.9 1.1 0.6 0.8 -1.1 -0.2 0.7 -0.1
Heart attack 1.4 1.8 2.9 -1.3 -1.4 -1.5 -0.0 -1.2 1.7 -1.7 -1.1 -1.1
Allergy 0.4 0.9 1.9 1.3 0.9 1.4 -0.0 1.2 0.2 0.7 1.2 0.5
Pain all over the body in last month 0.3 0.3 0.9 0.7 0.5 0.3 0.9 0.5 0.1 0.5 0.5 0.1
Diabetes (self-reported) 1.2 1.8 2.9 1.5 1.5 1.6 -1.6 1.7 -0.4 0.6 1.7 0.7
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.8 0.6 1.1 0.8 -0.0 0.9 -1.7 0.7 0.9 0.5
Medication: Ramipril 4.5 5.7 9.8 2.4 2.9 2.9 -1.8 2.6 -3.1 1.4 2.6 0.8
Medication: Simvastatin 1.2 1.7 3.7 1.0 1.2 1.2 -0.2 1.5 -0.0 1.9 1.5 1.8
Fluid intelligence score 0.3 0.6 2.6 -0.2 0.1 -0.0 1.6 -0.3 -1.4 -0.6 -0.3 -0.8
Illnesses of siblings 1.2 1.7 3.6 -1.5 -1.7 -1.7 0.3 -1.4 1.9 -0.2 -1.3 -0.0
Neuroticism score 0.7 1.5 6.4 -0.9 -0.9 -0.9 -0.1 -1.4 -0.6 -2.5 -1.4 -0.6
Weight 0.4 2.0 4.5 -1.4 -1.5 -1.3 -0.2 -1.5 1.0 -1.6 -1.5 -2.1
Impedance of arm (right) 0.3 1.5 3.0 1.3 1.3 1.4 -0.7 1.2 -1.1 0.9 1.2 1.7
Arm fat percentage (right) 0.0 0.2 1.1 -0.1 0.1 0.2 -0.3 0.1 -0.3 0.1 0.2 -1.1
Trunk fat-free mass 1.0 5.6 9.5 -2.2 -2.7 -2.3 -0.0 -2.6 1.8 -3.1 -2.7 -2.5
Hip circumference 0.7 3.0 5.3 -1.7 -1.9 -1.8 0.4 -1.7 2.3 -1.3 -1.7 -2.0
Time employed in main current job 0.1 0.1 0.6 0.1 0.1 0.1 0.7 -0.1 -0.1 -0.8 -0.0 -0.4
Alcohol intake versus 10 years previously 0.0 0.0 0.1 0.4 0.2 -0.0 0.2 0.1 0.2 -0.2 -0.0 0.4
Father’s age at death 0.4 0.5 2.3 -0.1 -0.2 -0.2 0.8 -0.5 -1.0 -0.7 -0.4 -1.5
Worrier / anxious feelings 0.4 0.7 2.4 -0.5 -0.7 -0.8 0.8 -0.8 0.0 -1.5 -0.9 -0.7
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.3 0.0 0.2 0.2 0.5 0.0 -0.5 -0.2 0.0 0.6
Falls in the last year 3.4 4.6 9.9 2.5 2.7 2.5 0.7 2.4 -3.1 0.2 2.4 0.4
Hair/balding pattern: Pattern 3 1.4 2.1 5.4 -1.6 -1.1 -1.3 0.1 -1.3 0.4 -2.3 -1.4 -2.1
Number of live births 0.1 0.2 1.3 0.5 0.3 0.3 -0.2 -0.0 -1.1 -0.1 -0.0 0.3
Forced expiratory volume in 1-second (FEV1) 0.7 2.2 3.8 -1.5 -1.7 -1.4 0.9 -1.9 0.7 -1.8 -1.9 -1.1
Pulse rate 0.2 0.4 1.3 0.4 0.4 0.5 0.0 0.5 0.3 1.2 0.5 1.1
Happiness 0.3 0.4 0.8 -0.9 -0.8 -0.7 -0.2 -0.8 0.3 -0.5 -0.7 0.1
Noisy workplace 0.2 0.3 1.3 -0.2 0.3 0.3 -1.1 0.3 -0.4 -0.7 0.3 -0.3
Qualifications: A levels/AS levels or equivalent 2.0 4.5 8.8 2.6 2.5 2.4 0.2 2.1 -3.0 1.7 2.0 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 2.0 -0.2 -0.2 -0.4 1.4 -0.3 0.2 0.7 -0.2 -0.1
Mouth/teeth dental problems: Dentures 0.2 0.4 0.9 0.3 0.7 0.7 -0.9 0.6 -0.5 0.7 0.6 0.2
Asthma 0.6 1.2 4.3 1.0 1.2 1.2 -0.7 0.7 -2.1 0.9 0.8 0.3
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.6 3.8 -1.6 -1.7 -1.8 1.3 -1.8 1.0 -1.3 -1.8 -2.0
Medication: Cholesterol lowering 0.3 0.5 1.1 0.5 0.8 0.7 -0.5 1.0 0.1 0.4 1.1 0.7
Depression (self-reported) 0.6 0.8 1.3 0.9 1.0 1.1 -0.1 1.0 -0.6 0.6 0.9 1.1
Medication: Lansoprazole 1.8 2.0 3.2 1.3 1.5 1.6 -0.3 1.4 -1.3 1.8 1.5 1.6
Prospective memory result 0.2 0.2 0.9 0.1 -0.1 -0.3 -0.9 0.2 0.8 -0.3 0.2 -0.0
Lung cancer (father) 2.6 3.1 4.5 1.9 2.0 1.8 0.4 2.1 -1.0 1.7 2.1 1.9
Illnesses of mother 1.0 1.2 2.3 -1.1 -1.5 -1.5 0.6 -1.2 1.5 -0.3 -1.1 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 1.8 -0.8 -0.8 -0.6 1.0 -1.1 -0.5 -1.3 -1.1 -0.9
Pulse wave Arterial Stiffness index 0.3 0.4 0.9 0.9 0.4 0.4 0.2 0.8 0.5 -0.8 0.7 -0.1
Impedance of arm (left) 0.2 1.1 1.9 1.1 1.1 1.1 -0.4 1.0 -1.0 1.1 1.0 1.4
Arm fat mass (right) 0.2 0.6 2.7 -0.8 -0.7 -0.6 -0.3 -0.7 0.3 -0.6 -0.7 -1.7
Trunk predicted mass 1.0 5.6 9.4 -2.2 -2.7 -2.3 -0.1 -2.6 1.8 -3.1 -2.7 -2.5
Standing height 0.5 5.4 10.6 -1.9 -2.7 -2.1 -0.8 -2.7 1.7 -3.3 -2.8 -1.9
Length of working week for main job 0.7 0.7 2.2 0.8 0.6 0.4 -0.9 0.8 0.5 0.9 0.8 1.5
Exposure to tobacco smoke at home 0.6 0.7 1.6 0.6 1.0 1.1 -1.3 0.9 -0.5 0.2 1.0 -0.3
Breastfed as a baby 0.4 0.5 1.3 -0.7 -0.7 -0.7 0.3 -0.5 0.9 -1.1 -0.5 0.5
Tense / ‘highly strung’ 1.2 2.1 3.5 -1.6 -1.7 -1.7 -0.5 -1.8 1.2 -1.3 -1.9 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 0.6 0.6 0.7 0.7 0.8 0.7 -0.7 0.4 0.6 -0.1
Hair/balding pattern: Pattern 4 0.7 1.8 2.9 -1.2 -1.3 -1.7 0.9 -1.4 0.3 -1.5 -1.4 -1.7
Birth weight of first child 0.6 1.2 2.3 -0.8 -1.0 -1.3 1.5 -1.1 0.6 -1.1 -1.1 -1.0
Peak expiratory flow (PEF) 0.5 1.0 2.1 -1.0 -0.9 -0.7 0.3 -1.3 -0.4 -1.4 -1.4 -1.1
Pulse wave reflection index 1.0 1.2 3.5 -0.6 -1.1 -1.1 0.7 -0.9 0.9 -1.9 -0.9 -1.4
Ever highly irritable/argumentative for 2 days 2.4 2.8 5.2 -2.0 -1.6 -1.8 0.2 -1.8 1.0 -1.8 -1.8 -2.3
Loud music exposure frequency 0.2 0.3 1.7 -0.0 -0.1 -0.2 -0.1 0.1 1.3 0.5 0.1 -0.6
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 6.3 0.1 0.3 0.4 -0.3 -0.2 -2.5 0.3 -0.2 0.3
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 2.4 0.4 0.4 0.3 1.6 0.3 -0.7 1.1 0.4 0.7
Blood clot in the leg (DVT) 2.2 2.9 4.1 -1.9 -1.9 -2.0 -1.1 -2.0 1.5 -1.4 -2.0 -1.3
Medication: Paracetamol 0.8 1.4 2.6 -1.3 -1.0 -1.1 -0.4 -1.5 -0.4 -1.1 -1.5 -1.6
Headache pain in last month 0.6 1.1 3.0 -0.4 -0.8 -0.7 0.9 -1.1 -0.2 -1.7 -1.1 -1.5
Medication for cholesterol, blood pressure or diabetes 0.3 0.6 2.4 -0.3 -0.6 -0.5 1.6 -0.8 -0.4 -0.4 -0.9 -0.4
Glaucoma (self-reported) 1.1 1.3 2.4 -1.2 -1.3 -1.3 -0.8 -1.1 1.5 -0.4 -1.1 -1.3
Gout (self-reported) 11.5 15.8 32.6 4.1 4.8 4.6 -1.3 3.9 -5.7 3.1 3.9 2.6
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 3.4 1.8 1.7 1.8 0.5 1.6 -1.5 0.7 1.6 1.6
Medication: Amlodipine 1.0 1.4 2.3 1.5 1.4 1.5 0.0 1.3 -1.5 -0.1 1.3 0.6
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.4 -0.2 -0.5 -0.4 0.0 -0.3 0.7 0.1 -0.3 -0.1
Birth weight 1.2 2.6 5.0 -1.6 -1.9 -2.2 0.6 -1.7 2.1 -1.0 -1.7 -0.7
Chronic bronchitis/emphysema (mother) 1.9 2.2 5.5 1.5 1.7 1.8 -0.9 1.3 -2.3 0.8 1.4 1.2
High blood pressure (siblings) 0.4 0.5 2.0 0.4 0.8 0.8 -0.3 0.6 -1.4 -0.7 0.5 -0.4
Forced vital capacity (FVC), Best measure 0.3 1.2 2.2 -1.0 -1.2 -0.9 0.9 -1.5 -0.3 -1.4 -1.5 -0.7
Body fat percentage 0.1 0.2 1.4 -0.3 -0.0 -0.0 -0.5 -0.0 0.2 0.0 0.0 -1.2
Leg fat percentage (right) 0.1 0.3 1.5 -0.6 -0.3 -0.3 -0.5 -0.2 0.5 -0.3 -0.2 -1.2
Arm fat-free mass (right) 0.8 4.1 6.2 -2.0 -2.2 -2.0 0.1 -2.2 1.5 -2.5 -2.2 -2.2
Exposure to tobacco smoke outside home 2.8 3.7 4.8 2.0 2.2 2.2 -1.8 2.0 -2.1 1.5 2.1 1.0
Comparative body size at age 10 1.3 3.5 10.9 1.6 1.6 1.5 0.8 2.1 0.5 3.3 2.1 1.7
Number of full brothers 0.8 1.0 2.8 1.0 0.9 0.8 1.7 0.6 -1.3 0.4 0.6 1.2
Worry too long after embarrassment 0.2 0.3 0.9 0.6 0.5 0.5 0.2 0.5 -0.6 -0.9 0.5 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.2 -0.1 -0.0 0.0 -0.2 0.1 0.2 0.0 0.1 -0.4
Wheeze or whistling in the chest in last year 0.3 0.5 2.6 0.5 0.3 0.4 0.3 0.2 -0.6 -0.9 0.2 -1.6
Number of children fathered 0.7 0.8 2.1 0.8 0.7 0.7 -1.1 0.9 -0.4 1.5 0.9 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.6 -0.4 -0.4 -0.3 -0.5 -0.3 0.8 -0.3 -0.2 -0.7
Age at first live birth 0.3 0.5 1.9 -0.7 -0.6 -0.6 1.4 -0.6 0.1 0.1 -0.5 -0.7
Pulse wave peak to peak time 0.5 0.5 1.3 -1.1 -0.7 -0.7 -0.3 -1.1 -0.2 0.4 -1.0 -0.1
Health satisfaction 0.3 0.4 1.0 -0.8 -0.5 -0.6 -0.8 -0.6 0.5 -1.0 -0.6 -0.3
Shortness of breath walking on level ground 0.6 0.7 2.0 0.4 0.6 0.7 -1.4 1.1 0.6 0.4 1.1 0.1
Qualifications: College or University degree 0.6 1.8 4.2 1.3 1.5 1.2 0.3 1.6 -0.9 2.1 1.6 0.5
Eye problems/disorders: None of the above 0.4 0.5 1.6 0.4 0.5 0.5 0.9 0.1 -1.3 0.4 0.1 1.2
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.3 -0.6 -0.5 -0.8 -0.3 -0.3 1.1 -0.6 -0.3 0.6
Emphysema/chronic bronchitis 0.5 0.6 1.0 0.9 0.9 1.0 -0.8 0.8 -0.4 0.8 0.9 0.3
Medication for pain relief, constipation, heartburn 0.2 0.3 0.5 0.6 0.5 0.6 0.5 0.7 -0.3 0.0 0.6 0.6
Neck or shoulder pain in last month 0.8 1.2 2.4 -1.4 -1.1 -1.0 0.5 -1.2 0.3 -1.6 -1.1 -1.2
Medication: Blood pressure 0.2 0.3 1.9 -0.0 0.4 0.3 -1.4 0.3 -0.3 -0.2 0.4 -0.2
Angina (self-reported) 0.2 0.2 1.5 -0.3 0.1 -0.2 0.2 0.1 0.1 -0.7 0.1 -1.2
Migraine (self-reported) 0.7 0.9 1.4 -1.0 -1.2 -1.0 -0.2 -1.1 1.1 -0.8 -1.1 -0.1
Medication: Ibuprofen 3.4 4.0 7.7 -2.0 -2.1 -2.1 1.0 -2.3 1.1 -1.7 -2.2 -2.8
Medication: Allopurinol 7.8 10.4 20.7 3.4 4.0 3.8 -0.5 3.3 -4.6 2.3 3.3 1.6
Medication: Omeprazole 0.6 0.7 1.5 0.9 0.7 0.7 0.0 1.0 0.4 0.9 1.0 1.2
Medication: Seretide 50 evohaler 0.9 1.0 1.9 -0.8 -1.0 -0.9 0.2 -1.2 0.1 -1.3 -1.1 -1.4
Mean time to correctly identify matches 0.4 0.8 1.3 1.1 0.9 0.8 -0.4 1.0 0.0 1.0 1.1 1.0
Heart disease (mother) 0.4 0.5 2.1 0.2 0.4 0.4 0.2 0.0 -1.2 -0.5 -0.0 -1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 1.6 1.1 1.1 1.3 -0.3 1.1 -0.9 1.0 1.1 0.4
Whole body fat mass 0.2 0.6 2.5 -0.8 -0.6 -0.5 -0.5 -0.7 0.5 -0.8 -0.6 -1.6
Leg fat mass (right) 0.2 0.7 2.8 -0.9 -0.7 -0.7 -0.3 -0.7 0.7 -0.5 -0.7 -1.7
Arm predicted mass (right) 0.7 3.7 5.9 -1.9 -2.2 -1.9 -0.1 -2.1 1.6 -2.4 -2.1 -2.1
Pulse rate, automated reading 0.1 0.4 2.8 -0.2 0.0 -0.0 -0.3 0.1 0.5 1.7 0.2 0.4
Alcohol intake frequency. 0.1 0.1 0.3 -0.3 -0.3 -0.5 -0.0 -0.6 0.1 -0.4 -0.6 -0.2
Comparative height size at age 10 0.2 1.1 2.6 -1.0 -1.3 -0.8 -0.6 -1.1 1.6 -1.0 -1.1 -0.0
Number of full sisters 0.8 1.0 2.1 1.1 1.2 1.1 0.1 1.0 -1.4 0.6 1.1 0.5
Suffer from ‘nerves’ 2.3 3.6 5.6 -2.2 -2.2 -2.4 0.2 -2.2 1.8 -1.9 -2.2 -0.7
Overall health rating 0.3 0.7 1.1 1.1 0.9 0.9 -0.8 0.9 -0.5 -0.3 1.0 0.7
Chest pain or discomfort 1.0 1.4 7.7 -0.9 -0.9 -1.0 -0.0 -1.0 -0.3 -2.8 -1.1 -0.6
Had major operations 0.3 0.3 0.8 0.5 0.6 0.6 0.1 0.9 0.3 -0.4 0.8 -0.4
Age at last live birth 0.3 0.4 1.8 -0.5 -0.4 -0.3 0.7 -0.4 -0.3 -0.7 -0.4 -1.3
Family relationship satisfaction 0.1 0.1 0.2 -0.3 -0.3 -0.1 -0.5 -0.3 -0.0 -0.5 -0.2 0.1
Leg pain on walking 0.2 0.2 0.7 -0.3 -0.3 -0.4 0.2 -0.2 0.6 -0.9 -0.1 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.1 0.2 -0.2 -0.2 -0.0 -0.2 -0.3 -0.4 -0.1 -0.3 0.0
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.7 -0.9 -0.9 -1.1 1.0 -0.8 1.3 0.2 -0.7 -0.1
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.6 0.1 0.1 0.2 -0.3 0.3 0.8 0.7 0.3 0.7
Medication: Aspirin 0.1 0.1 0.2 0.2 0.3 0.3 -0.5 0.3 -0.1 0.2 0.4 -0.4
Supplements: Vitamin C 0.5 0.6 3.6 -0.5 -0.3 -0.3 0.7 -0.4 0.2 -0.4 -0.3 -1.9
Knee pain experienced in last month 0.2 0.3 1.0 0.4 0.2 0.3 0.4 -0.1 -1.0 0.1 0.0 -0.9
Hypertension (Self-reported) 0.7 2.1 3.2 1.4 1.7 1.7 -1.8 1.7 -1.3 -0.0 1.6 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 3.0 0.5 0.6 0.8 -1.7 0.4 -1.3 1.2 0.4 0.9
Illnesses of father: Heart disease 0.2 0.2 1.4 -0.1 0.1 0.0 -1.2 0.2 0.4 0.2 0.3 0.5
Illnesses of siblings: Diabetes 0.9 1.1 1.8 1.2 1.0 1.2 -0.0 1.3 0.3 1.3 1.3 1.0
Smoking status: Previous 0.7 1.0 1.6 -1.0 -1.2 -1.3 -0.9 -1.1 1.0 -0.9 -1.1 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 2.3 0.8 0.6 0.9 -1.1 0.3 -1.5 0.2 0.3 0.3
Whole body fat-free mass 0.8 4.5 6.9 -2.0 -2.4 -2.1 -0.1 -2.4 1.4 -2.6 -2.4 -2.5
Leg fat-free mass (right) 0.3 1.8 3.5 -1.3 -1.5 -1.2 -0.0 -1.6 0.7 -1.4 -1.6 -1.9
Arm fat percentage (left) 0.0 0.1 1.1 -0.2 0.1 0.1 -0.2 0.0 -0.2 0.2 0.1 -1.1
Average weekly red wine intake 0.4 0.6 2.3 -0.5 -0.5 -0.5 -0.6 -0.3 0.7 -1.2 -0.3 -1.5
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.5 0.3 -0.1 -0.0 0.1 0.1 0.3 0.7 0.1 0.4
Mood swings 0.6 1.1 2.2 -1.0 -0.9 -0.8 0.2 -1.5 -0.5 -1.5 -1.4 -0.9
Loneliness, isolation 0.7 1.0 5.1 0.8 0.9 0.9 0.3 0.3 -2.3 -1.0 0.3 -0.3
Long-standing illness, disability or infirmity 0.2 0.3 1.4 0.5 0.5 0.5 -0.3 0.2 -1.2 -0.7 0.2 -0.1
Ever had bowel cancer screening 1.9 2.2 4.0 2.0 1.8 1.7 -0.6 2.0 -0.6 0.1 1.9 1.2
Diabetes diagnosed by doctor 1.1 1.8 2.9 1.6 1.6 1.6 -1.4 1.7 -0.6 0.6 1.7 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 3.3 -0.0 -0.0 0.1 -1.8 0.0 -0.3 0.4 0.1 -0.3
Friendships satisfaction 2.3 2.9 4.3 -2.1 -2.0 -2.0 -1.0 -1.9 1.8 -1.0 -2.0 -0.8
Qualifications: nursing, teaching 0.1 0.1 0.6 0.3 0.3 0.2 0.4 0.2 -0.2 0.8 0.2 0.5
Commuting to job workplace: Walk 0.2 0.3 1.0 0.5 0.5 0.6 0.5 0.3 -1.0 -0.0 0.3 -0.4
Eye problems/disorders: Cataract 0.1 0.1 0.9 0.2 -0.1 -0.0 -0.1 0.2 0.9 -0.2 0.2 0.1
Mouth/teeth dental problems: Mouth ulcers 3.0 4.7 8.1 -2.8 -2.5 -2.7 -0.4 -2.5 1.5 -1.7 -2.4 -1.9
Medication for cholesterol 0.2 0.3 0.8 -0.3 -0.5 -0.7 0.6 -0.4 0.6 -0.3 -0.4 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 3.6 -1.0 -0.7 -0.8 -1.9 -0.4 1.0 -0.1 -0.4 -0.4
Back pain experienced in last month 1.1 1.6 4.0 -1.1 -1.1 -1.0 -0.8 -1.3 -0.1 -2.0 -1.3 -1.6
Mineral and other dietary supplements 0.3 0.3 0.9 -1.0 -0.6 -0.8 0.2 -0.7 0.4 -0.4 -0.6 -0.1
Breast cancer (self-reported) 1.6 1.9 3.4 1.7 1.2 1.2 0.7 1.5 0.2 1.6 1.5 1.8
Asthma (self-reported) 0.9 1.9 5.7 1.4 1.6 1.6 -0.8 1.1 -2.4 1.1 1.2 0.2
Osteoporosis (self-reported) 0.9 1.1 2.7 1.4 1.0 1.2 1.7 0.8 -1.0 0.9 0.8 0.3
Osteoarthritis (self-reported) 1.3 1.7 3.4 1.4 1.7 1.7 -0.7 1.4 -1.8 0.6 1.3 0.0
Medication: Aspirin 0.1 0.1 0.2 0.1 0.3 0.3 -0.3 0.3 -0.1 0.4 0.3 -0.5
Medication: Gliclazide 2.6 2.9 4.3 2.0 2.0 2.0 -0.4 2.1 -1.3 1.5 2.1 1.3
Illnesses of father: None of the above (group 1) 0.2 0.2 1.3 -0.2 -0.4 -0.4 0.4 -0.4 0.2 0.1 -0.4 -1.1
Smoking status: Current 0.2 0.4 0.5 0.7 0.6 0.7 -0.7 0.6 -0.6 0.7 0.6 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.3 -1.0 -0.9 -0.9 1.0 -1.1 0.3 -1.0 -1.1 -0.5
Whole body water mass 0.8 4.4 6.9 -2.0 -2.4 -2.0 -0.0 -2.4 1.4 -2.6 -2.4 -2.5
Leg predicted mass (right) 0.4 2.0 3.7 -1.3 -1.5 -1.3 -0.0 -1.6 0.7 -1.5 -1.6 -1.9
Arm fat mass (left) 0.2 1.0 3.4 -1.0 -0.9 -0.8 -0.1 -1.0 0.4 -0.9 -0.9 -1.8
Number of self-reported non-cancer illnesses 1.2 2.2 3.4 1.8 1.9 1.9 -0.7 1.8 -1.3 1.0 1.8 -0.2
Average weekly champagne plus white wine intake 0.9 1.2 2.2 -1.1 -1.0 -1.1 -0.1 -0.8 1.3 -1.4 -0.9 -1.5
Miserableness 0.2 0.4 1.5 -0.3 -0.2 -0.2 0.6 -0.8 -1.2 -0.6 -0.8 -0.3
Guilty feelings 0.6 0.9 4.2 0.7 0.6 0.6 -2.1 0.5 -0.9 -0.2 0.5 1.1
Wears glasses or contact lenses 0.1 0.1 0.5 -0.2 -0.1 -0.1 -0.7 -0.0 0.0 -0.3 -0.0 0.5
Ever taken oral contraceptive pill 0.8 0.8 2.3 0.6 0.9 0.9 0.1 0.7 -1.5 1.5 0.7 0.1
Hearing aid user 0.2 0.2 0.5 0.5 0.5 0.5 -0.0 0.4 0.1 0.3 0.4 -0.7
Mother’s age at death 0.4 0.5 3.2 0.4 0.2 0.2 1.8 0.3 0.2 0.5 0.3 0.5
Financial situation satisfaction 0.2 0.2 0.5 -0.3 -0.3 -0.1 0.7 -0.4 -0.2 0.5 -0.4 -0.7
Tinnitus: Yes, now most or all of the time 0.2 0.2 1.2 0.0 -0.2 -0.0 -0.0 -0.1 0.4 1.1 -0.2 0.7
Commuting to job workplace: Public transport 0.3 0.4 1.2 0.4 0.5 0.6 -1.1 0.4 -1.0 -0.5 0.3 -0.1
Eye problems/disorders: Glaucoma 0.1 0.1 0.5 -0.2 -0.1 -0.2 -0.4 -0.1 0.4 0.1 -0.1 -0.7
Medication: Blood pressure 2.1 4.0 6.3 2.2 2.3 2.5 -1.4 2.3 -1.9 1.0 2.2 1.6
Pain type(s) experienced in last month: Hip pain 0.2 0.2 1.1 -0.2 -0.1 -0.3 -0.1 -0.4 -0.5 -1.1 -0.3 -0.2
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.5 0.2 0.0 0.1 0.5 0.0 0.1 -0.7 -0.0 -0.5
High cholesterol (Self-reported) 0.2 0.3 0.8 0.2 0.3 0.4 -0.9 0.6 0.0 0.5 0.6 0.7
Medication: Bendroflumethiazide 1.8 2.7 3.8 1.6 1.8 1.9 -0.8 1.5 -1.8 1.7 1.5 1.9
Medication: Paracetamol 0.6 1.0 2.3 -1.1 -0.7 -0.8 -0.8 -1.2 -0.3 -0.9 -1.1 -1.5
Medication: Lisinopril 0.3 0.4 0.7 0.8 0.7 0.8 0.1 0.8 -0.7 0.3 0.8 0.6
Medication: Atorvastatin 0.3 0.3 1.5 0.1 0.1 -0.0 -0.4 0.4 1.2 -0.2 0.5 0.8
Illnesses of father: High blood pressure 0.8 1.0 1.7 -1.1 -0.6 -0.7 -0.3 -1.2 -1.1 -1.3 -1.1 -0.9
Alcohol drinker status: Never 0.1 0.2 0.3 -0.3 -0.3 -0.5 -0.2 -0.6 0.3 0.0 -0.6 -0.5
Ever smoked 0.3 0.5 2.9 -0.2 -0.3 -0.3 -1.7 -0.1 0.6 -0.5 -0.0 0.5
Basal metabolic rate 0.7 3.7 5.8 -1.8 -2.1 -1.8 -0.0 -2.2 1.3 -2.3 -2.2 -2.4
Leg fat percentage (left) 0.1 0.2 1.3 -0.4 -0.1 -0.2 -0.6 -0.0 0.3 -0.2 0.0 -1.1
Arm fat-free mass (left) 0.7 3.6 5.1 -1.8 -2.1 -1.9 0.1 -2.1 1.5 -2.3 -2.1 -2.1
Number of operations (self-reported) 0.7 1.0 1.9 0.9 1.1 1.1 -0.1 1.4 0.1 0.9 1.4 -0.9
Average weekly beer plus cider intake 0.1 0.2 0.6 0.2 0.4 0.3 0.5 0.3 -0.4 0.8 0.4 0.6
Irritability 0.3 0.5 1.1 -0.8 -0.6 -0.6 0.0 -1.0 -0.5 -0.8 -1.1 0.3
Risk taking 0.3 0.5 2.0 -0.2 0.0 -0.0 0.3 -0.2 -1.1 -0.8 -0.2 -1.4
Ever had prostate specific antigen (PSA) test 1.2 1.4 2.5 1.5 1.1 1.4 -1.4 1.5 -0.3 0.2 1.6 0.5
Fractured/broken bones in last 5 years 0.6 0.7 3.2 0.5 0.3 0.6 0.8 0.1 -1.3 -0.4 0.1 -1.8
Age started oral contraceptive pill 1.2 1.5 2.7 1.6 1.5 1.4 -0.0 1.5 -1.1 0.7 1.4 0.9
Diastolic blood pressure, automated reading 0.5 1.5 3.5 -1.4 -1.3 -1.1 0.0 -0.8 1.8 -1.9 -0.9 -0.6
Ever depressed for a whole week 0.0 0.0 0.2 -0.3 -0.1 -0.2 -0.0 -0.1 0.1 0.4 -0.1 -0.0
Unable to work because of sickness or disability 1.3 1.7 2.6 1.1 1.5 1.4 -0.1 1.6 -0.8 1.6 1.6 1.3
Commuting to job workplace: Cycle 0.6 0.7 1.4 1.0 0.9 0.9 -0.2 1.1 -0.2 1.0 1.2 0.3
Myopia 0.2 0.3 1.1 0.3 0.4 0.3 0.3 0.2 -0.9 0.2 0.2 -1.0
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.0 -1.0 -1.2 -1.2 1.4 -1.4 0.5 0.1 -1.4 -0.4
Cholesterol lowering medication 0.4 0.6 2.8 -0.5 -0.6 -0.5 0.2 -0.1 1.7 0.8 -0.2 1.0
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.5 1.1 0.8 0.9 -0.4 1.1 0.3 1.2 1.1 1.6
Pain experienced in last month 0.8 1.3 3.3 1.1 1.1 1.1 -0.2 1.3 -0.4 1.2 1.2 1.8
Supplements: Calcium 2.9 3.1 5.1 2.0 1.8 2.0 -0.2 1.7 -1.4 2.0 1.7 2.2
Basal cell carcinoma (self-reported) 0.4 0.5 2.0 0.1 0.3 0.4 -0.3 -0.2 -1.4 0.6 -0.1 -1.2
Heart attack/myocardial infarction (self-reported) 1.5 1.9 2.9 -1.4 -1.5 -1.5 -0.0 -1.3 1.7 -1.7 -1.2 -1.3
Deep venous thrombosis (DVT) (self-reported) 1.6 2.1 3.1 -1.6 -1.6 -1.7 -1.0 -1.7 1.3 -1.1 -1.8 -1.0
Heart disease (siblings) 0.5 0.7 2.2 -0.4 -0.4 -0.5 -0.1 -1.0 -0.6 -1.5 -1.0 -0.9
Alcohol drinker status: Previous 0.4 0.4 1.0 -0.5 -0.8 -0.8 -0.8 -0.6 1.0 0.1 -0.6 -0.1
Pack years of smoking 0.2 0.2 0.9 0.4 0.4 0.5 -0.2 0.2 -0.6 -0.5 0.2 -0.9
Impedance of whole body 0.4 2.0 3.8 1.5 1.5 1.5 -0.7 1.5 -0.9 1.2 1.5 2.0
Leg fat mass (left) 0.2 0.6 2.5 -0.9 -0.7 -0.7 -0.4 -0.7 0.6 -0.5 -0.6 -1.6
Arm predicted mass (left) 0.6 3.1 4.6 -1.7 -2.0 -1.7 0.2 -2.0 1.4 -2.1 -2.0 -1.9