Hub : Genes

IER5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.118	0.0218	0.0000	0.093	0.107	0.114	0.11	0.105	1.1e-28	4.8e-33	2.6e-35	5.3e-34	1.6e-32
2	TCGA	Liver Hepatocellular Carcinoma	0.091	0.0560	0.0062	0.055	0.035	0.034	NA	0.024	1.4e-03	9.0e-03	9.6e-03	NA	2.6e-02
3	TCGA	Thyroid Carcinoma	0.054	0.0400	0.0031	0.022	0.023	0.022	NA	0.019	2.9e-03	2.2e-03	2.7e-03	NA	5.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.1	-0.3	0.5
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	-0.5	-0.5	0.4
Depressed Affect (Nagel 2018)	0.4	0.9	1.7	0.7	0.8	-1.3
Depression (Nagel 2018)	4.2	6.4	7.2	2.3	2.6	-2.7
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	-0.7	-0.0	0.6
Neuroticism (Nagel 2018)	2.4	5.8	7.7	2.1	2.3	-2.8
Schizophrenia (2018)	0.1	0.2	0.3	-0.6	-0.4	0.0
Schizophrenia vs Biploar Disorder	0.1	0.2	0.3	-0.3	-0.5	0.4
Worry (Nagel 2018)	1.0	2.1	3.1	1.3	1.2	-1.7
Alzheimer’s Disease (in mother)	1.0	1.2	1.8	1.3	0.8	-1.0
Alzheimer’s Disease (in father)	2.1	2.3	2.8	1.7	1.4	-1.5
Alzheimer’s Disease (including proxy)	2.7	3.9	5.7	2.4	1.8	-1.7
Crohns Disease (2017)	0.4	1.0	1.6	-0.7	-1.3	0.9
Irritable Bowel Disease (IBD)	0.6	1.3	2.1	-0.9	-1.4	1.1
Ulcerative Colitis (UC)	0.6	1.1	1.3	-1.0	-1.1	1.0
Major Depression (MDD)	3.5	4.2	4.8	2.0	1.9	-2.2
Reaction Time	0.8	1.5	1.8	1.1	1.4	-1.2
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.6	0.3	0.3
Breast Cancer	0.0	0.1	0.3	-0.2	-0.5	0.2
Ovarian Cancer	1.3	1.7	2.0	-1.4	-1.4	1.1
Prostate Cancer	0.1	0.2	0.3	0.2	0.5	-0.6
Age at First Birth	0.7	1.0	1.3	-1.1	-0.7	1.2
Bipolar Disorder (2011)	1.0	1.0	1.2	1.1	0.7	-1.1
Body Mass Index (BMI) (2010)	1.5	2.0	3.1	-1.8	-1.2	1.2
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.6	-0.2	0.2
Crohns Disease (2012)	0.1	0.2	0.3	0.3	-0.5	0.2
Mean Putamen Volume	8.9	10.2	11.1	-3.0	-3.3	3.3
Fasting Glucose	0.4	0.4	0.7	0.1	0.8	-0.8
HbA1C	0.0	0.0	0.0	0.1	0.0	-0.1
HDL Cholesterol	0.5	0.8	1.5	-0.7	-1.2	0.6
LDL Cholesterol	0.1	0.2	0.6	-0.7	0.2	-0.0
Lupus	2.7	4.1	4.8	-1.9	-2.2	2.0
Neuroticism (2016)	0.3	0.5	0.5	0.6	0.7	-0.6
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.3	0.1	-0.5
Rheumatoid Arthritis	0.3	0.4	0.5	-0.5	-0.7	0.6
Schizophrenia (2014)	0.4	0.9	1.4	-0.9	-1.2	0.8
Triglycerides	0.0	0.1	0.1	0.3	0.2	-0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	0.1	-0.1	-0.3
Ulcerative Colitis	0.1	0.2	0.4	-0.2	-0.6	0.4
Blood Eosinophil Count	4.0	31.0	32.9	5.7	5.5	-5.5
Blood Platelet Count	0.2	2.5	4.7	-1.0	-2.2	1.3
Blood Red Count	0.6	5.4	6.9	2.6	2.2	-2.1
Blood White Count	0.3	2.3	2.9	-1.0	-1.7	1.7
Heel T-Score	0.4	3.3	3.6	-1.9	-1.8	1.8
BMI	0.8	4.4	6.1	-2.5	-2.2	1.6
Height	0.1	2.1	3.0	-1.4	-1.2	1.7
Waist Hip Ratio (WHR)	0.1	0.3	0.6	0.8	-0.3	-0.3
Systolic Blood Pressure	0.8	3.8	4.0	-2.0	-1.9	2.0
Smoking Status	0.1	0.3	0.8	-0.3	-0.9	0.3
Allergy or Eczema	2.9	7.6	8.5	2.7	2.6	-2.9
Cardiovascular Disease	0.1	0.2	0.3	-0.5	-0.6	0.3
Hypothyroidism (self reported)	1.1	2.6	3.0	1.7	1.4	-1.7
Respiratory disease	0.0	0.1	0.1	-0.0	-0.3	0.3
Type 2 Diabetes (T2D) (2018)	1.8	3.4	4.3	-1.5	-1.9	2.1
Lung FEV1/FVC ratio	0.6	2.9	3.5	1.9	1.6	-1.6
Lung FVC	0.0	0.0	0.1	-0.1	-0.0	0.3
Neuroticism	1.2	2.8	4.0	1.2	1.7	-2.0
Chronotype (morning person)	0.4	1.0	1.8	-0.9	-0.7	1.3
Hair Pigment	0.0	0.1	0.4	0.6	-0.1	-0.1
Tanning	1.4	17.2	17.9	-4.2	-4.1	4.1
Hand grip strength (left)	0.7	1.7	2.6	-1.6	-1.1	1.2
Number of treatments/medications taken	0.3	0.5	0.7	0.8	0.8	-0.5
Average weekly spirits intake	2.5	3.1	4.4	-1.4	-2.1	1.8
Sensitivity / hurt feelings	0.2	0.3	0.5	-0.6	-0.7	0.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.1	0.4	-0.3
Hearing difficulty/problems: Yes	1.8	2.8	3.4	1.9	1.7	-1.4
Relative age of first facial hair	0.0	0.0	0.1	0.2	0.0	-0.2
Other serious medical condition/disability diagnosed by doctor	8.1	10.6	13.5	3.7	3.0	-3.0
Ever used hormone-replacement therapy (HRT)	4.8	6.1	6.9	2.4	2.6	-2.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	0.3	0.5	-0.6
Systolic blood pressure, automated reading	1.5	4.4	5.0	-2.1	-1.9	2.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	0.1	-0.5	0.6
Angina	0.0	0.0	0.1	0.2	0.2	0.1
Medication for hormone replacement therapy	1.3	1.5	1.5	1.2	1.2	-1.2
Vitamin and mineral supplements	1.1	1.5	1.7	-1.3	-1.1	1.2
Supplements: Zinc	0.3	0.3	0.4	0.4	0.5	-0.7
Medication: Co-codamol	0.3	0.3	0.5	0.6	0.7	-0.3
Medication: Metformin	3.4	4.7	5.1	-2.2	-2.1	2.3
Diabetes (father)	0.5	0.6	0.9	-0.9	-0.8	0.4
Diabetes (mother)	0.2	0.2	0.4	-0.1	-0.6	0.4
Severe depression (siblings)	3.6	4.0	5.5	2.3	1.9	-1.7
Pack years adult smoking proportion	0.1	0.1	0.2	-0.4	0.2	0.2
Impedance of leg (right)	0.9	4.3	6.1	2.5	1.8	-2.0
Leg fat-free mass (left)	0.6	3.3	4.1	-2.0	-1.5	1.8
Trunk fat percentage	0.0	0.0	0.0	-0.1	-0.1	-0.2
Hand grip strength (right)	0.0	0.1	0.2	-0.5	0.3	-0.2
Townsend deprivation index at recruitment	0.0	0.0	0.1	-0.1	-0.1	0.3
Current tobacco smoking	0.1	0.1	0.2	-0.1	-0.4	0.5
Average weekly fortified wine intake	0.5	0.6	0.8	0.9	0.6	-0.7
Maternal smoking around birth	0.2	0.2	0.3	-0.5	-0.5	0.4
Fed-up feelings	0.2	0.4	0.7	0.3	0.5	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	3.4	4.6	5.9	1.8	2.4	-2.1
Relative age voice broke	0.4	0.6	1.1	-0.6	-1.0	0.6
Taking other prescription medications	1.4	2.2	3.0	1.7	1.2	-1.4
Age when periods started (menarche)	0.3	0.8	1.2	0.8	1.1	-0.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.5	-1.2	-0.3	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.1	-0.2	-0.2	0.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	0.7	0.7	0.8	-0.8
Qualifications: CSEs or equivalent	6.8	9.0	10.3	-3.2	-2.7	3.1
Serious illness, injury or assault to yourself	1.9	2.4	2.6	1.6	1.6	-1.4
High blood pressure	0.1	0.4	0.6	-0.6	-0.6	0.7
Hayfever, allergic rhinitis or eczema	1.9	4.0	4.2	2.0	1.9	-2.0
Multivitamins +/- minerals	3.7	4.8	5.2	2.2	2.3	-2.1
Stomach or abdominal pain in last month	0.3	0.3	0.6	0.5	0.8	-0.4
Supplements: Glucosamine	1.0	1.3	2.1	1.5	1.0	-0.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	0.8	0.7	0.9	-0.8
Medication: Atenolol	0.3	0.3	0.7	-0.8	-0.4	0.5
Medication: Levothyroxine sodium	1.5	2.6	3.2	1.5	1.8	-1.6
Sitting height	0.8	5.6	6.6	-2.3	-2.2	2.6
Chronic bronchitis/emphysema (father)	1.6	1.9	3.2	1.1	1.8	-1.2
High blood pressure (mother)	0.1	0.2	0.2	-0.4	-0.4	0.5
Body mass index (BMI)	0.5	2.1	3.1	-1.8	-1.4	1.2
Impedance of leg (left)	0.9	4.5	6.1	2.5	1.8	-2.1
Leg predicted mass (left)	0.6	3.2	4.0	-2.0	-1.5	1.8
Trunk fat mass	0.1	0.3	0.5	-0.7	-0.5	0.5
Waist circumference	0.3	1.1	1.4	-1.0	-1.2	1.0
Number of incorrect matches in round	0.0	0.1	0.2	0.2	-0.0	0.4
Past tobacco smoking	0.2	0.4	0.9	-1.0	-0.2	0.6
Alcohol usually taken with meals	6.0	9.7	11.6	3.0	3.4	-2.9
Nervous feelings	0.8	1.4	1.5	-1.2	-1.2	1.1
Frequency of tenseness / restlessness in last 2 weeks	4.4	6.9	8.0	2.4	2.6	-2.8
Hearing difficulty/problems with background noise	1.1	1.7	2.2	1.4	1.5	-1.0
Hair/balding pattern: Pattern 2	0.2	0.3	0.5	0.5	0.2	-0.7
Had menopause	6.4	8.1	8.3	2.8	2.9	-2.9
Had other major operations	0.5	0.6	0.9	0.7	0.9	-0.6
Forced vital capacity (FVC)	0.3	1.1	1.4	-1.0	-0.9	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	1.8	-0.9	-1.2	1.3
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	3.0	1.1	1.7	-1.4
Qualifications: None of the above	0.1	0.2	0.4	0.3	0.6	-0.5
Financial difficulties in last 2 years	0.0	0.0	0.1	-0.1	0.3	-0.0
Mouth/teeth dental problems	2.2	3.4	4.4	-1.5	-2.1	1.8
Heart attack	0.1	0.1	0.2	-0.1	-0.3	0.4
Allergy	0.0	0.0	0.0	-0.2	-0.1	0.2
Pain all over the body in last month	2.1	2.3	2.5	1.6	1.4	-1.5
Diabetes (self-reported)	1.1	1.8	2.0	-1.4	-1.2	1.4
Hayfever/allergic rhinitis (self-reported)	4.1	5.5	5.6	2.4	2.3	-2.3
Medication: Ramipril	0.7	1.0	1.4	-0.9	-0.8	1.2
Medication: Simvastatin	0.2	0.3	0.4	-0.3	-0.6	0.5
Fluid intelligence score	0.2	0.4	0.7	-0.9	-0.3	0.5
Illnesses of siblings	0.1	0.1	0.2	-0.1	-0.4	0.3
Neuroticism score	0.2	0.5	0.7	0.4	0.9	-0.8
Weight	0.6	2.8	3.5	-1.9	-1.5	1.6
Impedance of arm (right)	0.4	2.1	3.5	1.9	1.2	-1.1
Arm fat percentage (right)	0.3	1.0	1.3	-1.1	-1.0	0.9
Trunk fat-free mass	0.5	2.7	3.5	-1.9	-1.2	1.8
Hip circumference	0.2	1.0	1.5	-1.2	-0.8	0.9
Time employed in main current job	0.4	0.5	0.6	-0.8	-0.8	0.3
Alcohol intake versus 10 years previously	1.0	1.6	2.5	-1.3	-0.7	1.6
Father’s age at death	1.9	2.5	3.1	1.4	1.8	-1.6
Worrier / anxious feelings	0.6	1.1	1.3	0.9	1.0	-1.1
Frequency of tiredness / lethargy in last 2 weeks	3.0	4.8	5.8	2.4	2.1	-2.0
Falls in the last year	0.1	0.1	0.3	-0.3	-0.0	0.6
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.3	0.1	0.5
Number of live births	0.2	0.3	0.4	0.3	0.6	-0.6
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.3	-0.3	-0.3	0.5
Pulse rate	1.0	1.8	3.0	-0.9	-1.7	1.2
Happiness	1.5	1.8	2.1	1.3	1.3	-1.4
Noisy workplace	0.3	0.4	0.6	-0.4	-0.8	0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	0.3	-0.4	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.5	0.6	1.2	-0.7
Mouth/teeth dental problems: Dentures	0.2	0.3	0.4	-0.5	-0.6	0.5
Asthma	1.4	2.7	2.9	-1.6	-1.7	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.6	-0.4	-0.7	0.8
Medication: Cholesterol lowering	1.0	1.6	2.0	-1.4	-1.2	1.1
Depression (self-reported)	0.7	0.9	1.6	0.7	0.8	-1.3
Medication: Lansoprazole	4.5	5.1	6.1	2.5	2.1	-2.2
Prospective memory result	0.0	0.0	0.1	-0.2	-0.1	-0.0
Lung cancer (father)	1.0	1.1	1.4	1.1	1.2	-0.8
Illnesses of mother	0.3	0.4	0.8	-0.9	-0.2	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	2.1	-1.0	-1.4	1.4
Pulse wave Arterial Stiffness index	0.1	0.2	0.3	-0.5	-0.3	0.3
Impedance of arm (left)	0.9	4.4	5.8	2.4	1.9	-1.9
Arm fat mass (right)	0.3	1.3	1.7	-1.3	-1.1	1.0
Trunk predicted mass	0.4	2.5	3.3	-1.8	-1.2	1.7
Standing height	0.1	0.6	1.1	-0.6	-0.5	1.1
Length of working week for main job	0.2	0.2	0.3	0.5	0.4	-0.5
Exposure to tobacco smoke at home	0.1	0.1	0.3	-0.3	0.5	0.1
Breastfed as a baby	3.8	4.7	5.1	-2.3	-2.0	2.2
Tense / ‘highly strung’	2.2	3.6	4.1	2.0	1.7	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	2.7	1.3	1.2	-1.6
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	-0.0	0.3	-0.2
Birth weight of first child	0.4	0.7	1.0	1.0	0.7	-0.8
Peak expiratory flow (PEF)	0.2	0.4	0.5	0.7	0.6	-0.4
Pulse wave reflection index	0.5	0.6	1.2	-1.1	-0.3	0.7
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	0.0	0.3	-0.1
Loud music exposure frequency	1.7	1.8	2.9	1.0	1.7	-1.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.8	-0.0	-0.9	0.9
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	4.1	1.2	2.0	-1.6
Blood clot in the leg (DVT)	6.0	7.7	10.0	-3.2	-2.8	2.3
Medication: Paracetamol	0.0	0.0	0.1	0.1	0.4	-0.1
Headache pain in last month	1.1	1.9	2.5	1.2	1.3	-1.6
Medication for cholesterol, blood pressure or diabetes	1.8	3.1	3.8	1.5	1.8	-1.9
Glaucoma (self-reported)	0.1	0.1	0.2	-0.1	-0.4	0.2
Gout (self-reported)	1.3	1.8	3.0	0.8	1.7	-1.3
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	3.5	1.8	1.5	-1.9
Medication: Amlodipine	0.9	1.2	1.8	-0.9	-1.1	1.3
Medication: Ventolin 100micrograms inhaler	0.5	0.6	0.8	-0.5	-0.8	0.9
Birth weight	0.4	0.9	1.4	0.9	1.2	-0.8
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.6	-0.4	0.4
High blood pressure (siblings)	0.0	0.1	0.2	-0.1	0.4	-0.0
Forced vital capacity (FVC), Best measure	1.7	6.2	6.9	-2.3	-2.6	2.6
Body fat percentage	0.0	0.0	0.1	-0.2	-0.2	-0.0
Leg fat percentage (right)	0.0	0.1	0.2	-0.2	-0.5	0.2
Arm fat-free mass (right)	0.4	2.2	3.2	-1.8	-1.2	1.4
Exposure to tobacco smoke outside home	0.2	0.2	0.3	-0.5	0.3	0.6
Comparative body size at age 10	1.5	4.3	5.2	-2.0	-2.3	1.9
Number of full brothers	0.1	0.2	0.3	0.4	0.6	-0.1
Worry too long after embarrassment	1.6	2.8	3.4	1.4	1.7	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	1.5	-1.2	-1.1	0.8
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	-0.0	-0.2	0.2
Number of children fathered	0.4	0.5	0.8	0.9	0.1	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	3.3	1.0	1.8	-1.0
Age at first live birth	1.2	2.1	2.7	-1.4	-1.6	1.3
Pulse wave peak to peak time	0.0	0.1	0.2	0.4	0.1	-0.0
Health satisfaction	0.1	0.2	0.2	0.2	0.5	-0.5
Shortness of breath walking on level ground	0.0	0.0	0.1	0.1	-0.2	0.3
Qualifications: College or University degree	0.0	0.0	0.1	-0.3	-0.2	-0.1
Eye problems/disorders: None of the above	0.9	1.0	1.7	0.8	0.9	-1.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.2	0.1	0.4
Emphysema/chronic bronchitis	0.1	0.1	0.3	0.2	0.2	0.5
Medication for pain relief, constipation, heartburn	0.3	0.4	0.8	0.4	0.6	-0.9
Neck or shoulder pain in last month	0.3	0.4	0.5	0.6	0.4	-0.7
Medication: Blood pressure	2.2	4.0	5.2	-1.5	-2.1	2.3
Angina (self-reported)	0.2	0.2	0.4	-0.4	-0.3	0.7
Migraine (self-reported)	0.1	0.1	0.1	-0.3	-0.0	-0.4
Medication: Ibuprofen	0.9	1.1	1.4	-0.8	-1.2	1.2
Medication: Allopurinol	3.3	4.5	6.7	1.5	2.6	-2.1
Medication: Omeprazole	0.2	0.2	0.3	-0.5	-0.4	0.4
Medication: Seretide 50 evohaler	0.7	0.8	1.3	-0.5	-0.9	1.1
Mean time to correctly identify matches	0.9	1.7	2.2	1.2	1.5	-1.1
Heart disease (mother)	1.1	1.3	2.0	1.1	0.8	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.0	4.7	5.8	2.4	2.3	-1.8
Whole body fat mass	0.1	0.6	0.8	-0.9	-0.7	0.7
Leg fat mass (right)	0.4	1.4	1.5	-1.2	-1.2	1.1
Arm predicted mass (right)	0.5	2.4	3.3	-1.8	-1.3	1.5
Pulse rate, automated reading	0.7	2.2	3.4	-1.0	-1.5	1.9
Alcohol intake frequency.	3.6	8.5	9.8	-2.9	-2.7	3.1
Comparative height size at age 10	0.4	2.1	3.7	-1.1	-1.1	1.9
Number of full sisters	0.1	0.1	0.1	-0.3	-0.2	0.3
Suffer from ‘nerves’	0.0	0.0	0.1	-0.3	0.2	-0.1
Overall health rating	1.0	2.1	2.7	1.7	1.3	-1.3
Chest pain or discomfort	1.6	2.3	2.8	1.7	1.6	-1.3
Had major operations	2.5	2.9	4.0	1.7	2.0	-1.4
Age at last live birth	0.6	0.8	0.9	-0.9	-0.9	0.9
Family relationship satisfaction	0.3	0.3	0.5	0.5	0.5	-0.7
Leg pain on walking	0.9	1.1	1.4	1.1	1.2	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	-0.8	-0.0	-0.0
Commuting to job workplace: Car/motor vehicle	0.5	0.5	0.8	-0.4	-0.8	0.9
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.9	0.1	-0.9	-0.0
Medication: Aspirin	0.8	1.0	1.4	-0.8	-1.0	1.2
Supplements: Vitamin C	0.4	0.5	0.9	-0.5	-0.9	0.5
Knee pain experienced in last month	0.0	0.1	0.1	0.4	-0.0	0.2
Hypertension (Self-reported)	0.0	0.1	0.1	-0.2	-0.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.3	-0.5	0.2
Illnesses of father: Heart disease	0.1	0.1	0.2	0.2	0.4	-0.2
Illnesses of siblings: Diabetes	2.3	2.8	3.8	-1.9	-1.4	1.6
Smoking status: Previous	0.1	0.1	0.3	0.0	-0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.3	-0.4	-0.4	0.5
Whole body fat-free mass	0.6	3.4	4.4	-2.1	-1.5	1.9
Leg fat-free mass (right)	0.7	3.5	4.6	-2.1	-1.6	1.9
Arm fat percentage (left)	0.1	0.3	0.5	-0.7	-0.5	0.4
Average weekly red wine intake	4.1	6.1	6.9	2.4	2.6	-2.3
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.5	-0.1	-0.2	0.7
Mood swings	0.1	0.2	0.3	0.5	0.4	-0.6
Loneliness, isolation	0.6	0.8	1.5	-1.2	-0.6	0.8
Long-standing illness, disability or infirmity	4.0	6.2	7.1	2.7	2.6	-2.1
Ever had bowel cancer screening	3.9	4.5	5.2	2.3	1.8	-2.3
Diabetes diagnosed by doctor	1.7	2.8	3.2	-1.6	-1.6	1.8
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.4	4.4	1.0	2.1	-1.3
Friendships satisfaction	0.0	0.0	0.1	0.0	0.2	-0.1
Qualifications: nursing, teaching	0.2	0.4	0.7	-0.1	-0.8	0.6
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.5	-0.4	0.1
Eye problems/disorders: Cataract	0.0	0.0	0.0	0.0	0.2	0.1
Mouth/teeth dental problems: Mouth ulcers	3.6	5.7	8.6	1.8	2.9	-2.3
Medication for cholesterol	0.3	0.4	1.1	-0.1	-1.0	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	2.9	1.2	1.7	-1.4
Back pain experienced in last month	3.4	4.9	5.2	2.2	2.3	-2.2
Mineral and other dietary supplements	0.1	0.2	0.5	-0.7	-0.4	0.0
Breast cancer (self-reported)	0.9	1.1	1.3	-0.8	-1.1	1.2
Asthma (self-reported)	1.4	2.8	2.9	-1.6	-1.7	1.7
Osteoporosis (self-reported)	0.1	0.1	0.3	-0.2	-0.6	0.1
Osteoarthritis (self-reported)	2.1	2.7	4.3	2.1	1.2	-1.6
Medication: Aspirin	0.9	1.1	1.7	-0.8	-1.1	1.3
Medication: Gliclazide	0.6	0.6	1.0	-0.7	-1.0	0.6
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.2	-0.1	-0.1
Smoking status: Current	0.0	0.0	0.0	0.0	-0.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.5	0.7	0.5	-0.5
Whole body water mass	0.6	3.3	4.2	-2.1	-1.5	1.9
Leg predicted mass (right)	0.7	3.6	4.7	-2.2	-1.6	1.9
Arm fat mass (left)	0.2	0.8	1.2	-1.1	-0.8	0.7
Number of self-reported non-cancer illnesses	1.2	2.2	2.7	1.5	1.6	-1.2
Average weekly champagne plus white wine intake	2.3	3.1	4.1	1.6	1.6	-2.0
Miserableness	0.1	0.1	0.2	0.1	0.4	-0.5
Guilty feelings	0.8	1.2	1.8	0.9	1.4	-1.0
Wears glasses or contact lenses	6.3	7.2	10.4	3.2	2.3	-2.4
Ever taken oral contraceptive pill	3.2	3.6	4.7	2.0	2.2	-1.4
Hearing aid user	0.1	0.2	0.3	0.5	0.4	-0.3
Mother’s age at death	0.1	0.1	0.1	0.3	-0.4	0.1
Financial situation satisfaction	2.7	3.4	3.5	1.8	1.8	-1.9
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	-0.4	0.2	0.1
Commuting to job workplace: Public transport	0.2	0.3	0.6	0.4	0.3	-0.8
Eye problems/disorders: Glaucoma	1.0	1.2	1.5	-1.2	-1.1	1.0
Medication: Blood pressure	0.1	0.2	0.4	-0.6	0.2	0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	0.1	-0.4	0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	-0.2	0.1	0.5
High cholesterol (Self-reported)	0.1	0.2	0.4	0.7	0.4	-0.3
Medication: Bendroflumethiazide	3.7	5.6	6.6	-2.0	-2.5	2.6
Medication: Paracetamol	0.0	0.0	0.0	-0.1	0.1	0.1
Medication: Lisinopril	0.7	0.9	1.2	-1.1	-1.0	0.8
Medication: Atorvastatin	0.3	0.4	0.6	-0.7	-0.2	0.8
Illnesses of father: High blood pressure	0.2	0.3	0.4	0.4	0.5	-0.6
Alcohol drinker status: Never	1.0	1.2	1.4	-1.2	-1.0	1.1
Ever smoked	0.2	0.4	0.9	0.9	0.2	-0.4
Basal metabolic rate	0.6	3.3	4.3	-2.1	-1.5	1.8
Leg fat percentage (left)	0.0	0.0	0.1	0.1	-0.2	-0.1
Arm fat-free mass (left)	0.5	2.7	3.5	-1.9	-1.4	1.6
Number of operations (self-reported)	2.4	3.5	4.8	1.6	2.2	-1.7
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.4	-0.2	0.8
Irritability	4.3	7.3	9.5	2.3	3.1	-2.6
Risk taking	0.3	0.5	0.8	0.6	0.9	-0.5
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.9	0.6	1.0	-0.4
Fractured/broken bones in last 5 years	1.6	2.0	2.5	-1.4	-1.2	1.6
Age started oral contraceptive pill	0.4	0.5	0.7	-0.8	-0.4	0.8
Diastolic blood pressure, automated reading	0.3	0.9	1.1	-1.0	-0.9	1.0
Ever depressed for a whole week	1.6	1.9	2.4	1.6	1.4	-1.2
Unable to work because of sickness or disability	0.5	0.6	1.0	1.0	0.7	-0.6
Commuting to job workplace: Cycle	0.4	0.5	0.9	-0.4	-0.6	1.0
Myopia	0.1	0.2	0.3	-0.0	0.6	-0.5
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.4	0.6	0.3	-0.7
Cholesterol lowering medication	0.0	0.0	0.1	-0.1	0.3	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.2	0.5	-0.3
Pain experienced in last month	1.4	2.4	2.7	-1.6	-1.4	1.6
Supplements: Calcium	1.2	1.3	2.0	1.0	1.4	-0.9
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	0.3	-0.2	-0.4
Heart attack/myocardial infarction (self-reported)	0.0	0.1	0.1	-0.1	-0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	5.4	6.9	8.9	-3.0	-2.6	2.2
Heart disease (siblings)	0.7	0.9	1.1	0.8	1.1	-1.0
Alcohol drinker status: Previous	2.0	2.2	2.5	-1.3	-1.6	1.6
Pack years of smoking	0.1	0.2	0.4	-0.6	-0.0	0.4
Impedance of whole body	1.1	5.6	7.3	2.7	2.1	-2.3
Leg fat mass (left)	0.2	0.7	0.8	-0.9	-0.9	0.7
Arm predicted mass (left)	0.6	2.9	3.5	-1.9	-1.5	1.7