Hub : Genes

IGFALS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1560	0.0440	9.5e-06	0.008	0.048	0.033	0.047	0.012	3.1e-02	1.5e-06	5.5e-05	2.0e-06	1.1e-02
2	METSIM	Adipose	0.0751	0.0312	4.0e-04	0.032	0.012	0.011	0.014	0.010	1.4e-05	6.1e-03	7.6e-03	2.6e-03	8.8e-03
3	ROSMAP	Brain Pre-frontal Cortex	0.1311	0.0331	8.0e-10	0.115	0.079	0.088	0.104	0.108	1.4e-14	2.1e-10	2.3e-11	2.8e-13	9.2e-14
4	TCGA	Breast Invasive Carcinoma	0.0399	0.0227	7.2e-06	0.025	0.027	0.030	NA	0.025	5.8e-06	2.5e-06	6.6e-07	NA	4.7e-06
5	TCGA	Brain Lower Grade Glioma	0.0985	0.0549	2.8e-04	-0.001	0.028	0.020	NA	0.010	4.2e-01	3.7e-04	2.0e-03	NA	2.1e-02
6	TCGA	Lung Adenocarcinoma	0.0941	0.0803	7.7e-07	0.080	0.057	0.050	NA	0.073	1.3e-09	3.1e-07	1.7e-06	NA	6.6e-09
7	TCGA	Rectum Adenocarcinoma	0.3650	0.1620	5.4e-03	0.020	0.045	0.043	NA	0.012	1.1e-01	3.3e-02	3.5e-02	NA	1.6e-01
8	TCGA	Thyroid Carcinoma	0.3650	0.0950	0.0e+00	0.428	0.410	0.395	NA	0.421	3.4e-45	9.3e-43	6.9e-41	NA	2.8e-44

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	0.8	1.3	4.2	0.5	0.2	0.5	-0.8	1.0	-1.4	-2.1	-1.4
Bipolar Disorder or Schizophrenia	2.2	5.2	10.8	2.6	0.9	1.5	-2.0	2.6	-2.2	-3.3	-2.3
Depressed Affect (Nagel 2018)	2.0	4.2	9.5	0.5	1.1	1.3	-2.8	0.3	-3.0	-1.9	-3.1
Depression (Nagel 2018)	1.1	1.6	7.3	-0.3	1.4	0.6	-0.9	2.7	0.1	-1.5	-0.4
Intelligence (Savage-Jansen 2018)	0.4	1.3	8.7	0.2	0.1	-3.0	0.3	0.1	0.2	1.1	0.0
Neuroticism (Nagel 2018)	0.5	1.1	3.4	-0.3	0.6	0.1	-1.6	-0.2	-1.8	-0.2	-1.6
Schizophrenia (2018)	2.1	4.5	9.5	3.1	1.0	1.5	-1.9	2.6	-1.7	-2.6	-1.8
Schizophrenia vs Biploar Disorder	0.3	0.4	3.0	0.1	1.7	-0.1	0.1	0.4	0.4	0.1	0.3
Worry (Nagel 2018)	0.3	0.6	1.4	-0.9	0.3	-0.9	-0.4	-0.8	-0.6	1.2	-0.4
Alzheimer’s Disease (in mother)	0.4	0.4	1.8	-0.5	-0.1	-1.3	-0.2	-1.1	-0.2	0.3	-0.4
Alzheimer’s Disease (in father)	0.9	1.0	2.9	1.7	-1.7	0.6	-0.7	-0.1	-0.6	-0.3	-0.8
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	0.3	-0.9	-0.8	-0.2	-0.9	-0.4	0.5	-0.2
Crohns Disease (2017)	0.5	1.1	2.4	-0.8	-0.2	-0.9	1.2	0.9	1.4	0.8	1.6
Irritable Bowel Disease (IBD)	0.6	1.4	2.5	-1.3	-1.1	-1.4	1.0	0.1	1.2	1.2	1.6
Ulcerative Colitis (UC)	0.2	0.5	1.3	-0.8	-1.1	-0.5	0.4	-0.5	0.3	0.5	0.9
Major Depression (MDD)	0.1	0.2	0.4	0.0	0.0	0.0	0.7	0.4	0.5	0.4	0.6
Reaction Time	1.4	2.6	6.4	-1.4	-2.5	-1.5	1.5	-1.3	1.9	1.3	1.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.9	0.2	0.5	-1.4	-1.3	0.8	-0.9	0.2	-0.9
Breast Cancer	0.3	0.8	2.4	-0.9	-1.6	-0.8	0.4	-1.2	0.1	0.8	0.6
Ovarian Cancer	2.5	3.4	6.0	0.9	1.7	1.9	-1.9	1.4	-1.8	-2.4	-2.1
Prostate Cancer	4.4	6.1	8.9	1.7	1.2	2.8	-2.9	1.5	-3.0	-2.9	-3.0
Age at First Birth	0.2	0.4	0.6	-0.2	0.7	-0.3	-0.2	0.7	0.8	0.8	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	1.7	0.6	-0.2	0.6	0.8	0.4	0.9	1.0	1.3
Coronary Artery Disease (CAD)	0.2	0.2	0.6	-0.0	0.8	-0.5	-0.0	0.8	0.2	0.3	-0.2
Crohns Disease (2012)	0.1	0.2	0.5	-0.4	-0.7	0.3	-0.3	0.2	-0.4	0.6	-0.1
Mean Putamen Volume	2.8	3.2	5.0	1.3	2.2	0.7	-1.9	1.0	-2.2	-2.2	-2.0
Fasting Glucose	0.7	0.9	2.5	0.7	0.7	0.3	-1.6	0.3	-1.3	-0.3	-1.2
HbA1C	0.4	0.5	1.0	-0.3	0.7	-0.0	-0.8	-0.1	-1.0	-0.9	-0.8
HDL Cholesterol	0.4	0.6	2.0	-0.0	1.4	-0.6	-0.5	0.9	-0.5	-0.9	-0.3
LDL Cholesterol	0.9	1.4	3.4	1.2	-0.7	0.7	-1.2	-0.9	-1.7	-0.7	-1.8
Lupus	0.5	0.7	1.5	1.0	-0.7	-0.7	0.4	1.2	1.0	-0.9	0.6
Neuroticism (2016)	0.5	0.8	2.7	0.5	1.6	0.3	-1.0	0.3	-1.0	-0.6	-0.9
Primary Biliary Cirrhosis	0.4	0.5	1.6	-0.2	0.5	1.3	-0.7	1.1	-0.1	-0.7	-0.5
Rheumatoid Arthritis	1.3	1.8	5.9	-0.5	0.5	-0.6	1.4	1.1	2.4	0.4	2.2
Schizophrenia (2014)	2.4	5.4	9.7	2.6	2.0	2.0	-2.2	2.7	-1.4	-3.1	-2.2
Triglycerides	1.4	2.3	5.0	1.4	-0.2	2.2	-1.8	-0.5	-1.8	-0.8	-2.1
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.7	-0.9	-0.3	-0.4	-0.8	-0.7	-0.7	-0.0	-0.8
Ulcerative Colitis	0.1	0.2	0.5	0.2	-0.5	-0.2	0.0	-0.3	-0.5	0.7	0.7
Blood Eosinophil Count	0.4	2.9	11.6	-2.4	-1.2	-0.7	1.1	-3.4	0.1	1.6	-0.0
Blood Platelet Count	0.8	9.8	22.2	-3.9	-4.7	-3.1	2.3	-3.4	1.9	3.0	1.7
Blood Red Count	0.5	5.0	12.5	0.3	-1.3	-2.6	1.7	-1.2	2.6	3.5	2.9
Blood White Count	0.9	6.7	16.7	-4.1	-2.0	-3.0	2.6	-2.6	1.0	2.7	1.5
Heel T-Score	0.6	4.9	12.6	3.5	2.3	1.6	-2.8	1.2	-1.4	-2.0	-1.8
BMI	0.1	0.7	3.3	0.4	0.9	-1.8	-0.0	0.6	0.7	-0.1	0.4
Height	1.0	19.1	68.1	-8.2	-1.8	-4.0	4.0	-3.7	3.2	3.8	3.2
Waist Hip Ratio (WHR)	0.2	1.1	4.2	-2.0	0.1	-0.5	-0.5	-1.7	-0.5	0.6	-0.8
Systolic Blood Pressure	2.1	10.4	23.9	-3.0	-4.2	-3.2	2.0	-3.0	2.1	4.9	2.0
Smoking Status	0.4	1.0	3.2	-1.8	1.7	0.1	-0.5	0.9	0.0	-0.7	-0.4
Allergy or Eczema	0.2	0.5	1.4	0.3	0.7	-0.7	-0.8	0.0	-1.2	0.1	-0.9
Cardiovascular Disease	2.9	9.7	19.6	-2.8	-3.1	-3.1	2.5	-2.1	3.4	4.4	3.0
Hypothyroidism (self reported)	1.8	4.1	7.2	-2.5	-0.1	-2.3	1.8	-1.8	2.1	2.7	1.8
Respiratory disease	0.4	1.0	2.4	0.7	0.3	-1.1	-0.9	-0.9	-1.5	0.1	-1.6
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.8	0.3	0.4	-0.1	-2.0	0.4	-1.6	-0.3	-1.8
Lung FEV1/FVC ratio	1.1	5.7	11.3	-3.2	1.0	-2.7	2.3	-1.3	3.4	2.1	2.2
Lung FVC	1.1	5.8	20.4	-0.7	-4.5	-0.9	2.5	-2.2	0.9	2.8	2.2
Neuroticism	0.1	0.3	1.0	-0.3	0.4	-0.6	-1.0	-0.1	-0.5	0.6	-0.6
Chronotype (morning person)	3.2	7.4	15.6	2.3	3.8	2.8	-1.6	4.0	-1.3	-3.3	-0.8
Hair Pigment	0.0	0.9	2.4	1.5	-0.2	-0.4	1.1	0.4	1.2	0.6	1.2
Tanning	0.4	4.9	9.9	1.9	2.3	3.0	-1.7	3.1	-0.7	-2.7	-1.0
Hand grip strength (left)	0.5	1.3	3.5	-1.3	0.9	0.5	-0.8	0.5	-1.9	-1.1	-1.3
Number of treatments/medications taken	0.2	0.4	1.2	0.6	-0.3	0.1	-0.7	-0.0	-1.1	0.8	-0.8
Average weekly spirits intake	0.8	1.0	1.5	-1.1	-0.9	-1.2	1.1	-1.0	0.8	0.9	0.7
Sensitivity / hurt feelings	0.8	1.4	3.7	-0.5	0.4	1.0	-1.3	-0.9	-1.8	0.2	-1.9
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.4	-0.3	0.9	1.4	-0.6	1.6	-0.4	-1.1	-0.5
Hearing difficulty/problems: Yes	2.1	3.2	7.6	2.5	0.8	-0.8	-2.8	1.8	-1.7	-1.3	-1.7
Relative age of first facial hair	1.3	2.7	10.6	-0.3	3.3	0.4	-0.9	2.1	-0.9	-2.0	-0.7
Other serious medical condition/disability diagnosed by doctor	1.0	1.2	3.9	0.1	-0.2	-1.7	1.1	0.0	2.0	0.9	1.1
Ever used hormone-replacement therapy (HRT)	1.6	2.0	6.9	2.6	1.4	0.9	0.1	1.7	0.8	-1.6	-0.4
Ever had hysterectomy (womb removed)	1.4	1.6	3.2	1.1	1.8	1.4	-1.0	1.4	-0.6	-1.0	-1.3
Systolic blood pressure, automated reading	1.8	5.3	15.0	-1.0	-2.9	-2.2	1.5	-1.6	1.9	3.9	2.1
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	3.1	0.5	1.0	-0.9	-0.0	1.8	0.9	-0.4	0.4
Angina	0.1	0.1	0.3	-0.0	0.1	0.5	-0.2	0.4	0.1	0.3	-0.2
Medication for hormone replacement therapy	0.2	0.2	1.2	0.5	1.1	-0.2	0.1	0.1	-0.1	0.1	0.1
Vitamin and mineral supplements	0.5	0.6	1.4	1.0	0.6	0.4	1.2	0.6	0.8	-0.6	0.9
Supplements: Zinc	0.4	0.4	1.2	0.7	-0.4	0.3	-0.9	-0.2	-0.7	0.1	-1.1
Medication: Co-codamol	1.4	1.6	4.0	0.1	-1.4	-1.2	-0.7	-1.5	-2.0	0.8	-1.4
Medication: Metformin	0.9	1.2	2.4	1.6	1.5	-1.1	-1.1	0.9	-1.1	0.1	-0.9
Diabetes (father)	3.1	3.9	11.4	0.3	0.9	1.5	-2.4	-0.7	-3.4	-0.8	-3.1
Diabetes (mother)	1.0	1.3	2.9	0.1	0.6	1.6	-0.7	-0.6	-1.2	-1.5	-1.7
Severe depression (siblings)	1.7	1.9	3.8	0.3	0.6	1.6	-1.6	0.8	-1.5	-1.8	-1.9
Pack years adult smoking proportion	2.1	3.3	10.2	1.2	0.1	3.2	-1.7	2.2	-1.4	-1.8	-1.3
Impedance of leg (right)	1.5	7.4	20.2	-2.6	-4.5	-1.0	2.3	-3.9	1.1	2.9	1.0
Leg fat-free mass (left)	0.2	0.9	3.4	-0.8	1.9	-0.8	0.8	0.4	1.0	-0.4	0.6
Trunk fat percentage	0.2	0.8	2.2	0.8	-1.5	-0.5	-0.3	-1.3	-0.7	0.1	-0.8
Hand grip strength (right)	0.2	0.6	3.6	-1.9	0.6	0.0	-0.2	0.4	-0.8	-0.5	-0.3
Townsend deprivation index at recruitment	2.0	2.8	6.7	-1.7	-2.6	-0.5	1.8	-1.9	1.4	1.4	1.4
Current tobacco smoking	0.4	0.7	1.7	-0.9	1.3	0.3	-0.6	1.2	0.4	-0.8	-0.0
Average weekly fortified wine intake	3.2	3.7	7.8	-1.1	-2.8	-2.3	1.5	-2.0	1.7	2.3	1.1
Maternal smoking around birth	0.2	0.3	1.2	-1.1	0.8	0.6	-0.1	0.3	-0.3	-0.3	0.2
Fed-up feelings	1.5	2.8	6.3	0.7	1.1	1.4	-2.5	0.9	-1.9	-1.7	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	5.5	0.0	1.4	1.4	-1.1	2.3	-0.3	-1.6	-0.7
Relative age voice broke	0.5	0.8	3.8	-1.9	0.9	-0.4	0.6	-0.5	0.5	0.3	0.7
Taking other prescription medications	0.3	0.4	0.9	0.6	-0.5	-0.6	0.1	-1.0	-0.6	0.7	-0.6
Age when periods started (menarche)	0.3	0.6	1.4	-1.2	-0.6	-0.9	1.0	-0.4	1.0	0.5	0.5
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	2.5	0.9	1.0	1.6	-0.4	0.8	0.7	-0.9	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.1	9.6	2.0	2.3	1.0	-2.4	1.4	-2.5	-3.1	-2.7
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.7	0.4	0.6	-0.5	1.2	0.5	1.3	-0.0	1.3
Qualifications: CSEs or equivalent	0.5	0.6	2.7	-0.6	-0.6	0.5	0.3	-1.6	-0.4	-0.3	-1.0
Serious illness, injury or assault to yourself	2.0	2.4	6.6	0.5	-0.7	1.3	-2.4	-0.1	-2.0	-0.6	-2.6
High blood pressure	2.2	6.1	11.2	-3.0	-2.1	-2.8	1.6	-1.6	2.3	3.3	2.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.1	-1.2	0.2	-1.8	-0.3	-0.9	-0.5	0.6	-0.8
Multivitamins +/- minerals	0.6	0.7	2.5	-0.3	0.2	0.6	-1.6	-0.1	-1.0	0.4	-1.2
Stomach or abdominal pain in last month	2.7	3.4	5.6	-1.4	-2.4	-1.9	1.9	-2.2	1.3	1.9	1.5
Supplements: Glucosamine	1.1	1.4	3.7	1.8	0.7	-0.1	-1.9	0.9	-1.1	-0.8	-1.3
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.6	-0.9	-1.2	-0.9	1.4	-1.5	1.4	1.9	1.4
Medication: Atenolol	1.5	1.9	4.8	-1.2	-1.5	-1.4	0.0	0.0	1.5	2.2	1.5
Medication: Levothyroxine sodium	0.6	0.9	1.8	-1.4	0.7	-1.1	0.8	-1.0	0.9	1.1	0.5
Sitting height	0.2	1.2	3.5	-1.9	-1.1	-0.4	0.9	-1.7	0.1	1.1	-0.3
Chronic bronchitis/emphysema (father)	0.2	0.3	1.2	1.1	0.1	0.5	-0.3	0.5	0.2	0.6	0.2
High blood pressure (mother)	0.1	0.2	0.5	0.5	0.2	-0.1	-0.4	0.7	0.3	-0.6	0.2
Body mass index (BMI)	0.1	0.6	2.4	1.5	0.6	-0.1	-0.5	1.1	0.1	-0.7	-0.1
Impedance of leg (left)	1.7	8.3	21.3	-2.9	-4.6	-1.2	2.4	-3.8	1.5	3.2	1.6
Leg predicted mass (left)	0.2	0.9	3.9	-0.8	2.0	-0.8	0.8	0.6	0.9	-0.4	0.6
Trunk fat mass	0.1	0.4	1.1	0.1	-0.9	-0.9	0.5	-1.0	0.2	0.4	0.1
Waist circumference	0.4	1.4	3.3	-1.0	-0.8	-1.8	1.1	-1.3	1.1	1.1	0.9
Number of incorrect matches in round	1.3	2.2	8.6	-1.9	-0.4	-2.9	1.5	-0.7	1.1	0.7	1.0
Past tobacco smoking	0.2	0.4	1.0	0.8	-0.9	0.2	-1.0	0.0	-0.7	0.4	-0.2
Alcohol usually taken with meals	0.7	1.1	2.7	1.6	0.3	0.7	-0.9	-0.5	-1.5	-1.0	-1.0
Nervous feelings	0.6	1.1	3.5	-0.3	0.6	0.3	-1.5	-0.6	-1.9	0.7	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	-1.0	-0.2	0.3	-0.9	-0.3	-0.8	0.4	-0.7
Hearing difficulty/problems with background noise	0.9	1.4	5.2	0.2	0.4	-0.8	-2.3	0.9	-1.3	-0.1	-1.5
Hair/balding pattern: Pattern 2	0.2	0.2	1.0	0.2	-0.6	1.0	-0.0	-0.3	0.3	0.2	-0.1
Had menopause	0.2	0.2	0.8	-0.3	0.1	0.4	-0.9	-0.2	0.5	0.2	-0.7
Had other major operations	1.0	1.2	6.0	-0.9	-0.7	-2.4	0.1	-0.7	0.4	1.4	-0.1
Forced vital capacity (FVC)	1.8	7.1	13.6	-2.5	-3.7	-2.0	3.0	-2.6	1.9	2.9	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.3	1.4	0.6	0.2	-1.7	0.6	-1.5	-1.4	-1.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.2	-1.0	-0.8	-0.8	0.9	-0.1	0.9	1.1	1.1
Qualifications: None of the above	1.1	2.3	7.9	1.2	0.3	2.8	-0.8	1.4	-1.5	-1.7	-1.0
Financial difficulties in last 2 years	0.5	0.6	1.3	-0.7	-1.0	0.5	-0.2	-1.0	-0.9	0.0	-1.1
Mouth/teeth dental problems	0.4	0.6	1.7	-1.3	-0.4	0.8	0.9	-0.5	0.2	-1.0	0.4
Heart attack	0.5	0.6	2.0	1.4	0.3	1.1	-0.9	0.3	-0.1	0.6	-0.5
Allergy	0.4	1.0	3.1	0.7	0.6	1.5	-0.2	1.8	-0.0	-1.1	0.7
Pain all over the body in last month	0.9	1.0	2.1	-0.4	0.8	1.0	-1.2	0.2	-1.5	-0.8	-1.4
Diabetes (self-reported)	0.6	0.9	2.0	1.4	-0.1	-0.3	-1.4	-0.3	-1.2	0.2	-1.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	-0.6	0.2	-0.8	-0.3	-0.3	0.1	-0.3	-0.5
Medication: Ramipril	0.7	0.9	1.7	-0.9	0.1	-1.2	-1.3	0.1	-1.3	0.8	-0.8
Medication: Simvastatin	0.3	0.4	1.1	0.4	0.8	0.8	0.1	0.6	0.9	-0.1	1.0
Fluid intelligence score	0.5	0.9	2.3	0.9	0.1	-1.5	-1.3	1.1	-1.1	0.4	-0.6
Illnesses of siblings	1.7	2.4	4.8	0.1	1.2	1.6	-1.7	0.6	-2.0	-1.8	-2.2
Neuroticism score	0.3	0.7	1.1	-0.8	0.3	-0.6	-0.9	-0.9	-0.9	1.0	-1.0
Weight	0.2	0.9	1.7	-1.0	0.1	-1.3	1.3	-0.4	1.2	0.6	0.9
Impedance of arm (right)	0.7	3.1	9.2	0.1	-2.4	0.5	-1.0	-3.0	-2.1	0.3	-2.1
Arm fat percentage (right)	0.3	1.2	3.8	1.9	-0.7	0.0	-1.2	-0.3	-1.1	-0.7	-1.3
Trunk fat-free mass	0.8	4.6	9.1	-3.0	1.1	-1.8	2.7	-0.2	2.8	1.3	2.5
Hip circumference	0.3	1.5	4.4	-0.7	-1.0	-2.1	1.4	-0.7	1.4	0.9	1.0
Time employed in main current job	0.3	0.4	1.3	0.4	1.1	0.6	-1.0	0.5	-0.2	-0.4	0.1
Alcohol intake versus 10 years previously	2.5	3.8	8.8	-2.0	-1.5	-1.4	3.0	-2.4	1.2	2.0	1.5
Father’s age at death	1.4	1.9	7.6	-0.8	-1.9	-1.0	0.2	-2.8	-0.5	1.3	-0.6
Worrier / anxious feelings	1.2	2.4	8.2	-0.8	-1.7	-1.7	0.7	-1.7	0.6	2.9	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.3	-0.4	-0.2	0.1	0.4	-0.4	0.4	0.7	1.1
Falls in the last year	0.2	0.2	0.6	-0.7	-0.3	-0.1	0.2	-0.6	0.8	-0.4	0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	-0.9	-0.1	-0.2	0.6	-0.2	0.6	0.6	0.5
Number of live births	1.5	2.2	5.0	1.6	-0.3	0.3	-2.0	0.7	-2.1	-0.9	-2.2
Forced expiratory volume in 1-second (FEV1)	2.0	6.6	10.1	-2.7	-2.8	-2.2	3.2	-2.4	2.2	2.5	2.3
Pulse rate	1.0	1.6	3.4	-1.1	-1.8	0.5	1.1	-1.6	1.2	1.4	1.1
Happiness	0.9	1.1	4.3	-2.1	1.9	-0.6	0.1	0.2	0.2	0.2	-0.1
Noisy workplace	0.6	0.7	2.2	0.6	1.3	0.5	-1.0	1.5	0.1	-0.4	-0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.3	0.1	0.9	-1.1	-0.4	0.2	-0.5	0.3	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.9	-0.1	0.0	-1.2	1.1	-0.1	1.7	-0.2	0.9
Mouth/teeth dental problems: Dentures	1.7	2.8	6.7	2.0	1.0	1.4	-2.6	1.7	-1.5	-1.5	-1.3
Asthma	0.5	0.9	3.1	-0.2	-0.5	-0.9	-0.3	-1.8	-1.1	0.4	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.9	-0.3	0.0	-0.9	0.5	-0.3	0.6	0.7	0.5
Medication: Cholesterol lowering	0.1	0.2	1.1	1.0	-0.0	-0.0	0.2	0.1	-0.1	-0.3	0.1
Depression (self-reported)	1.1	1.3	3.2	1.4	0.8	0.5	-0.7	1.7	-0.7	-1.8	-0.7
Medication: Lansoprazole	1.6	1.8	5.5	0.5	0.3	0.8	-2.2	0.2	-2.3	-0.4	-1.7
Prospective memory result	0.5	0.6	1.5	1.1	-0.2	1.2	-0.8	0.1	-0.3	-0.3	-1.0
Lung cancer (father)	0.3	0.3	0.7	0.4	-0.2	0.8	0.6	-0.0	0.7	0.4	0.7
Illnesses of mother	0.6	0.7	3.0	-0.9	-0.9	-0.4	0.1	-0.7	0.2	1.7	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	2.7	8.5	12.8	-3.2	-2.9	-2.7	3.6	-2.8	2.1	3.2	2.6
Pulse wave Arterial Stiffness index	0.6	0.7	2.5	0.4	-1.6	0.7	-0.1	-1.3	-0.5	0.2	-0.7
Impedance of arm (left)	0.7	3.3	8.8	0.1	-2.2	0.3	-1.1	-3.0	-2.4	0.1	-2.4
Arm fat mass (right)	0.1	0.3	0.8	0.9	-0.0	-0.7	-0.4	-0.2	-0.3	-0.4	-0.6
Trunk predicted mass	0.8	4.6	8.7	-3.0	1.0	-1.9	2.7	-0.2	2.8	1.4	2.5
Standing height	1.1	10.8	31.7	-5.6	-1.1	-2.9	3.8	-3.5	2.5	2.8	2.1
Length of working week for main job	2.2	2.4	6.4	-1.4	-0.7	-1.2	2.0	-0.2	2.5	0.8	2.1
Exposure to tobacco smoke at home	0.4	0.5	1.3	0.2	-0.2	-1.1	1.0	-0.2	0.5	1.0	0.6
Breastfed as a baby	0.9	1.1	2.7	-1.2	-1.3	-1.0	0.3	-1.6	-0.2	1.3	0.5
Tense / ‘highly strung’	0.1	0.2	0.5	0.3	0.6	-0.4	-0.5	0.2	-0.4	0.2	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	3.1	1.0	0.6	0.1	-1.1	-0.5	-1.8	-0.7	-1.4
Hair/balding pattern: Pattern 4	0.4	1.0	2.0	1.2	1.3	0.8	-0.7	1.2	-0.7	-1.4	-0.0
Birth weight of first child	1.4	2.5	5.3	2.2	0.4	-0.6	-2.3	1.9	-1.4	-0.9	-1.8
Peak expiratory flow (PEF)	0.2	0.6	2.0	-0.5	0.7	-0.5	1.4	0.3	1.0	-0.0	0.7
Pulse wave reflection index	0.3	0.4	1.3	0.4	-0.6	0.1	0.7	-1.1	-0.7	0.3	-0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	-0.7	0.2	0.8	-0.5	0.1	-1.0	-1.1	-0.9
Loud music exposure frequency	2.5	2.7	5.2	0.3	2.2	1.6	-1.6	2.3	-1.1	-2.1	-1.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.6	-1.2	-0.5	-1.0	0.2	-1.1	0.0	1.3	0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.4	1.0	0.0	-0.6	-0.2	-0.0	0.4	1.2	-0.1
Blood clot in the leg (DVT)	1.5	2.0	4.5	0.1	-1.0	-1.2	2.0	-0.8	2.1	1.2	1.7
Medication: Paracetamol	0.5	0.8	2.6	0.3	0.1	0.8	-0.8	-0.8	-1.6	0.5	-1.2
Headache pain in last month	0.4	0.8	2.7	-0.2	-1.2	-1.6	0.3	-0.7	-0.3	1.1	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.3	0.0	1.1	0.3	-0.4	0.6	-0.1	-0.7	-0.2
Glaucoma (self-reported)	1.3	1.5	4.5	-1.1	-2.1	-0.8	0.2	-1.9	-0.3	1.3	-0.4
Gout (self-reported)	0.8	1.2	3.5	0.2	1.9	-0.3	0.6	1.7	1.2	-0.1	1.0
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	4.9	-2.1	0.4	-1.9	1.4	-1.3	1.6	2.2	1.7
Medication: Amlodipine	1.9	2.6	4.8	-2.2	-1.6	-1.9	1.0	-0.7	1.4	2.2	1.4
Medication: Ventolin 100micrograms inhaler	0.6	0.8	3.4	-0.1	-0.6	-0.6	-0.4	-0.6	-1.8	0.1	-1.2
Birth weight	1.7	3.6	6.3	1.2	2.0	2.0	-2.2	2.5	-1.5	-2.0	-1.6
Chronic bronchitis/emphysema (mother)	2.1	2.5	4.3	1.1	1.2	1.5	-1.4	1.6	-1.8	-2.1	-1.6
High blood pressure (siblings)	1.3	1.9	4.1	1.0	0.6	-1.6	1.5	0.8	1.9	0.8	2.0
Forced vital capacity (FVC), Best measure	2.0	7.2	10.5	-2.8	-3.2	-2.2	3.1	-2.7	1.6	3.2	2.4
Body fat percentage	0.2	0.7	2.5	0.9	-1.6	-0.4	-0.2	-1.1	-0.4	0.2	-0.5
Leg fat percentage (right)	0.4	1.3	4.3	0.2	-2.1	-0.6	1.2	-1.2	1.0	1.1	0.9
Arm fat-free mass (right)	0.7	3.7	6.4	-2.3	0.6	-2.1	2.4	-0.2	2.5	1.5	2.2
Exposure to tobacco smoke outside home	0.2	0.3	0.9	-0.5	1.0	0.6	0.4	0.4	0.2	0.1	0.5
Comparative body size at age 10	1.3	3.7	10.5	-0.1	1.1	-0.5	1.7	2.4	3.2	0.1	3.0
Number of full brothers	1.4	1.7	4.7	-0.2	-2.2	-0.3	1.3	-1.8	0.5	1.4	1.3
Worry too long after embarrassment	1.6	2.6	4.6	-1.7	-0.3	-2.1	1.7	-0.1	1.8	1.7	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.7	0.2	-0.4	-0.7	-0.5	-0.3	-0.8	0.3	-0.3
Wheeze or whistling in the chest in last year	0.4	0.8	2.4	0.4	-0.8	-0.4	-1.0	0.1	-1.6	-0.3	-1.3
Number of children fathered	1.1	1.3	4.1	2.0	-0.5	1.3	-0.9	1.5	-0.4	-0.7	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.5	0.9	-0.5	-0.4	-1.2	0.1	-1.1	-0.7	-1.2
Age at first live birth	2.3	4.0	13.3	-0.6	0.2	-3.7	1.6	-0.5	2.5	2.2	2.1
Pulse wave peak to peak time	0.6	0.8	2.2	-0.6	1.5	-0.9	0.3	1.1	0.7	-0.1	0.8
Health satisfaction	0.5	0.6	2.8	-0.7	-0.1	-0.6	0.3	-0.3	1.0	1.7	0.5
Shortness of breath walking on level ground	0.3	0.3	1.0	-0.2	-0.5	1.0	-0.6	0.3	-0.2	0.8	-0.2
Qualifications: College or University degree	0.2	0.7	3.2	-0.6	1.1	-1.8	-0.5	-0.0	-0.4	0.3	-0.4
Eye problems/disorders: None of the above	0.6	0.7	3.6	0.7	-0.2	-0.4	0.9	-0.1	0.7	0.7	1.9
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.6	0.3	-0.6	0.8	1.1	0.7	1.6	-0.5	1.4
Emphysema/chronic bronchitis	0.4	0.4	1.9	0.8	0.4	0.5	0.2	1.4	0.3	-0.1	0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.9	-0.7	0.2	0.1	0.0	1.2	0.3	-1.4	0.1
Neck or shoulder pain in last month	0.5	0.7	1.2	-0.9	0.7	-0.6	1.1	0.1	1.1	0.6	1.1
Medication: Blood pressure	0.5	0.9	2.6	-0.5	-1.6	-0.8	0.3	-1.2	0.1	1.4	0.3
Angina (self-reported)	0.1	0.1	0.5	0.2	0.0	0.7	-0.3	0.2	-0.2	0.1	-0.4
Migraine (self-reported)	0.6	0.7	4.2	0.4	0.4	2.0	-0.2	0.9	0.5	-0.5	0.3
Medication: Ibuprofen	0.3	0.3	1.3	-0.7	0.5	-1.1	-0.0	-0.1	0.4	0.9	-0.1
Medication: Allopurinol	1.5	2.0	6.8	1.5	2.6	0.5	-0.6	2.0	0.4	-1.4	-0.1
Medication: Omeprazole	0.8	0.9	2.5	-0.1	-0.3	-0.9	1.4	-1.6	0.8	0.9	0.8
Medication: Seretide 50 evohaler	0.7	0.9	2.3	1.5	1.1	0.7	-1.2	0.5	-0.3	-0.6	-0.8
Mean time to correctly identify matches	2.0	3.8	7.7	-1.3	-2.2	-1.9	2.1	-1.0	2.8	1.7	2.2
Heart disease (mother)	0.6	0.7	2.1	0.8	1.2	-0.6	-0.7	1.4	0.5	-0.4	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	1.0	0.3	0.8	-1.0	0.3	-0.2	-0.0	0.1	0.5
Whole body fat mass	0.1	0.4	0.8	0.2	-0.9	-0.8	0.5	-0.8	0.5	0.3	0.2
Leg fat mass (right)	0.2	0.8	1.1	0.2	-1.1	-0.9	1.1	-0.8	1.1	0.7	0.9
Arm predicted mass (right)	0.6	3.3	6.8	-2.0	1.1	-1.9	2.2	0.4	2.6	1.1	2.2
Pulse rate, automated reading	0.1	0.4	1.3	0.2	-1.1	0.9	0.7	-0.8	-0.1	-0.4	-0.1
Alcohol intake frequency.	0.2	0.5	1.9	-0.5	-0.8	1.4	-0.3	-0.6	-0.9	0.3	-0.4
Comparative height size at age 10	0.6	3.4	8.8	-3.0	-0.1	-0.6	2.5	-2.5	1.7	1.2	1.4
Number of full sisters	0.9	1.1	2.5	1.0	-0.7	0.7	-1.0	-0.7	-1.6	-0.9	-1.5
Suffer from ‘nerves’	1.1	1.7	4.2	-1.2	-0.8	-1.7	-0.0	-2.0	-0.8	1.8	-0.7
Overall health rating	0.2	0.5	1.7	-0.3	0.0	-0.9	0.0	0.6	1.3	0.6	0.8
Chest pain or discomfort	1.1	1.5	6.2	-0.4	-1.2	-1.0	0.6	-1.5	0.3	2.5	0.8
Had major operations	0.2	0.2	0.9	0.1	-0.9	-0.5	0.2	-0.4	-0.4	0.6	0.2
Age at last live birth	2.3	3.3	13.4	-1.0	-0.9	-3.7	1.4	-0.4	1.7	1.9	1.7
Family relationship satisfaction	0.6	0.7	2.4	-1.5	0.6	-1.2	0.9	0.3	0.7	-0.0	0.4
Leg pain on walking	0.3	0.4	0.9	-1.0	0.0	0.5	-0.5	-0.4	-0.8	0.7	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.7	1.3	0.1	0.8	0.1	0.2	0.3	-0.3	-0.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.8	1.0	1.2	-0.2	-0.7	0.6	-0.9	-1.3	-1.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.5	0.1	1.0	-0.8	-1.2	0.7	-1.2	-0.3	-0.5
Medication: Aspirin	0.2	0.3	1.0	1.0	-0.2	0.7	-0.6	-0.6	-0.4	0.3	-0.5
Supplements: Vitamin C	0.5	0.6	2.6	-0.4	-1.6	0.3	0.2	-1.5	0.0	0.2	0.0
Knee pain experienced in last month	0.2	0.3	1.0	1.0	0.4	-0.5	0.1	0.4	0.6	-0.6	0.3
Hypertension (Self-reported)	3.3	9.2	16.7	-3.3	-2.8	-3.2	2.3	-2.0	3.0	4.1	3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.3	0.6	0.6	1.1	-1.0	-0.8	-1.1	-0.5	-1.1
Illnesses of father: Heart disease	2.7	3.7	12.0	-0.7	0.6	-0.3	1.7	1.3	3.3	1.1	3.5
Illnesses of siblings: Diabetes	0.2	0.3	0.6	0.2	-0.4	-0.5	-0.7	-0.8	-0.2	0.7	-0.4
Smoking status: Previous	0.5	0.8	2.9	-0.9	-0.1	0.1	1.7	-0.8	1.0	0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	5.3	-2.3	-0.4	-1.6	1.7	-1.1	1.3	1.0	1.1
Whole body fat-free mass	0.5	2.7	4.8	-2.1	1.4	-1.6	2.0	0.1	2.2	0.7	1.8
Leg fat-free mass (right)	0.2	1.1	5.0	-0.7	2.2	-0.7	0.6	0.9	0.9	-0.6	0.7
Arm fat percentage (left)	0.3	1.1	3.3	1.8	-0.7	-0.2	-1.2	-0.3	-1.2	-0.7	-1.4
Average weekly red wine intake	0.8	1.3	2.9	0.9	1.6	0.3	-0.8	1.7	-0.6	-1.6	-0.3
Handedness (chirality/laterality): Left-handed	3.8	4.6	9.4	1.7	3.1	-0.2	-2.4	2.6	-1.9	-2.1	-1.9
Mood swings	0.3	0.6	2.0	-0.5	0.1	-0.1	-0.9	-0.4	-1.4	-0.3	-1.1
Loneliness, isolation	1.3	1.8	3.1	1.4	0.9	0.8	-1.5	1.1	-1.3	-1.7	-1.8
Long-standing illness, disability or infirmity	0.5	0.8	2.1	1.0	-1.0	-0.2	-1.5	-0.1	-1.0	-0.1	-1.1
Ever had bowel cancer screening	0.5	0.6	1.3	0.9	-0.2	-0.7	0.6	0.9	0.9	-0.1	1.2
Diabetes diagnosed by doctor	0.8	1.4	4.0	1.4	0.5	-0.0	-2.0	0.3	-1.3	-0.1	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.4	0.0	-0.4	-1.0	0.9	0.1	1.2	-0.2	0.3
Friendships satisfaction	0.5	0.6	1.5	-0.6	-0.2	-1.2	0.6	-0.2	0.7	1.2	0.4
Qualifications: nursing, teaching	0.8	1.2	4.3	-0.7	-0.2	-2.1	0.3	-0.8	0.9	1.8	0.5
Commuting to job workplace: Walk	0.1	0.1	0.6	0.6	0.1	-0.7	0.2	0.3	0.2	-0.1	-0.3
Eye problems/disorders: Cataract	0.4	0.5	1.9	-0.5	0.8	-1.4	0.1	0.5	0.8	-0.2	0.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	4.2	-0.1	-1.1	-1.7	0.8	-1.4	-0.3	2.1	0.2
Medication for cholesterol	0.5	0.8	2.9	0.4	0.9	0.2	-0.1	0.4	-0.7	-1.7	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	-0.2	-0.3	-0.6	0.3	-0.7	0.1	0.7	-0.2
Back pain experienced in last month	0.5	0.7	2.5	-0.9	0.6	-0.1	-0.4	-0.3	-1.6	-0.7	-1.1
Mineral and other dietary supplements	0.9	1.1	3.5	0.2	-0.7	-0.9	1.9	-0.5	1.4	0.7	1.2
Breast cancer (self-reported)	0.3	0.4	1.0	-1.0	0.8	0.2	0.3	0.5	0.3	-0.8	-0.3
Asthma (self-reported)	0.5	1.1	4.0	-0.3	-0.6	-1.2	0.0	-2.0	-1.0	0.7	-1.1
Osteoporosis (self-reported)	0.7	0.9	3.3	0.5	1.8	0.8	-0.1	1.3	0.2	-1.1	0.1
Osteoarthritis (self-reported)	0.3	0.4	1.2	-0.1	1.1	-1.1	0.2	0.3	0.7	-0.4	0.4
Medication: Aspirin	0.3	0.4	1.3	1.2	0.4	0.4	-0.9	-0.0	-0.4	0.1	-0.5
Medication: Gliclazide	0.8	0.9	2.0	0.2	1.4	-0.3	-1.4	0.9	-1.2	0.1	-0.9
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	-0.3	0.5	-0.5	-0.0	-0.0	-0.5	-0.4	-0.6
Smoking status: Current	0.5	0.7	1.8	-0.9	1.3	-0.0	-0.5	1.3	0.4	-1.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.7	9.7	-0.1	-1.1	-1.2	3.1	-1.3	1.6	2.4	2.6
Whole body water mass	0.5	2.7	5.0	-2.2	1.3	-1.6	2.0	0.1	2.1	0.8	1.8
Leg predicted mass (right)	0.2	1.1	5.2	-0.7	2.3	-0.8	0.6	0.8	0.9	-0.5	0.6
Arm fat mass (left)	0.0	0.2	0.5	0.6	-0.1	-0.7	-0.3	-0.1	-0.1	-0.3	-0.4
Number of self-reported non-cancer illnesses	0.3	0.6	1.4	-0.4	0.7	-1.2	0.3	0.5	1.1	0.4	0.7
Average weekly champagne plus white wine intake	0.4	0.5	1.3	1.1	-0.4	-0.7	-0.3	-0.8	-0.3	-0.3	-1.1
Miserableness	1.5	2.5	6.9	-0.8	0.6	0.7	-1.3	-1.6	-2.4	-1.4	-2.6
Guilty feelings	0.2	0.3	1.1	0.1	-0.4	0.1	-0.2	0.0	0.6	1.0	0.6
Wears glasses or contact lenses	0.2	0.3	0.6	0.2	0.2	-0.3	-0.7	-0.3	-0.6	-0.6	-0.8
Ever taken oral contraceptive pill	0.5	0.5	1.2	-1.1	-0.1	0.5	-1.0	-0.2	-0.8	-0.4	-1.0
Hearing aid user	0.5	0.6	2.9	0.4	-1.7	-0.3	0.3	-0.7	0.6	0.9	0.3
Mother’s age at death	0.9	1.2	2.6	1.3	0.5	0.6	-1.0	1.5	-0.6	-1.6	-1.0
Financial situation satisfaction	0.1	0.1	0.4	-0.1	0.0	0.2	-0.3	-0.0	0.3	0.7	0.1
Tinnitus: Yes, now most or all of the time	1.1	1.3	4.2	0.8	1.0	2.0	-1.0	1.7	0.5	-0.8	0.3
Commuting to job workplace: Public transport	0.6	0.7	1.6	0.2	0.5	0.3	-1.3	0.1	-1.2	0.8	-1.2
Eye problems/disorders: Glaucoma	0.9	1.0	2.8	-0.9	-1.7	0.1	-0.3	-1.7	-0.9	0.0	-1.0
Medication: Blood pressure	2.2	4.1	7.3	-2.7	-1.8	-1.9	1.2	-1.2	2.1	2.6	2.2
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.1	0.6	0.6	0.1	-1.2	0.6	-1.4	-0.4	-1.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.1	-0.1	0.9	0.9	-1.0	0.8	-0.4	-0.8	-0.4
High cholesterol (Self-reported)	0.4	0.8	2.3	1.4	0.1	-0.1	0.5	0.8	1.5	0.1	1.0
Medication: Bendroflumethiazide	2.0	3.0	5.5	-1.4	-1.5	-0.6	2.2	-1.3	2.3	1.5	2.3
Medication: Paracetamol	0.7	1.1	3.3	0.8	0.1	1.0	-1.3	-0.3	-1.8	-0.1	-1.5
Medication: Lisinopril	1.3	1.7	4.8	-1.2	-0.9	-0.8	0.8	-2.2	0.7	1.9	1.2
Medication: Atorvastatin	0.4	0.5	2.7	1.6	-0.8	0.3	-0.1	0.2	-0.5	-0.2	-0.5
Illnesses of father: High blood pressure	0.2	0.2	0.6	-0.4	0.8	-0.1	0.1	0.4	0.8	0.1	0.4
Alcohol drinker status: Never	0.1	0.1	0.4	-0.6	0.2	-0.0	0.3	-0.4	0.6	0.0	0.2
Ever smoked	0.7	1.2	2.4	-0.7	1.2	-1.4	1.4	0.7	1.6	-0.2	1.0
Basal metabolic rate	0.4	2.3	4.0	-2.0	1.1	-1.6	1.9	-0.1	1.9	0.7	1.6
Leg fat percentage (left)	0.4	1.5	3.8	0.1	-2.0	-0.8	1.2	-0.9	1.4	1.2	1.4
Arm fat-free mass (left)	0.7	3.6	7.1	-2.2	0.7	-1.9	2.2	0.3	2.7	1.4	2.4
Number of operations (self-reported)	0.2	0.3	1.3	1.1	-0.5	-0.6	-0.3	0.2	-0.3	-0.4	-0.5
Average weekly beer plus cider intake	0.1	0.1	0.3	0.5	-0.3	-0.0	-0.1	-0.1	0.4	-0.4	-0.4
Irritability	0.6	1.0	2.5	-0.1	1.2	0.3	-1.5	0.2	-1.6	-0.1	-1.3
Risk taking	0.5	0.7	1.9	0.4	1.4	-0.4	0.2	0.9	1.0	-1.0	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.8	0.8	0.6	-0.9	0.6	0.5	0.9	-0.2	0.5
Fractured/broken bones in last 5 years	0.5	0.6	1.2	-0.9	0.5	0.4	0.5	1.0	1.0	-0.4	1.1
Age started oral contraceptive pill	0.9	1.2	3.8	0.8	0.6	1.4	-1.3	2.0	-0.1	-0.6	-0.7
Diastolic blood pressure, automated reading	1.1	3.3	9.9	-0.4	-2.2	-1.9	1.3	-1.5	1.4	3.1	1.5
Ever depressed for a whole week	1.0	1.2	3.2	-0.1	0.9	-1.0	1.0	1.2	1.8	0.1	1.6
Unable to work because of sickness or disability	0.7	0.8	2.5	-0.2	0.3	1.4	-0.3	1.4	-0.6	-1.6	-0.1
Commuting to job workplace: Cycle	0.2	0.2	0.9	-0.4	0.2	-1.0	0.5	-0.1	-0.2	-0.5	-0.2
Myopia	0.1	0.2	0.5	-0.7	-0.1	-0.7	-0.0	0.5	-0.1	0.2	-0.1
Vascular/heart problems diagnosed by doctor	1.4	4.0	8.0	2.8	1.7	1.8	-1.2	1.1	-1.8	-2.8	-1.9
Cholesterol lowering medication	0.8	1.2	3.5	1.7	0.8	1.1	-0.9	1.9	0.8	-0.5	0.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.1	1.0	-0.1	0.5	0.1	-1.0	-0.2	0.1	-0.2
Pain experienced in last month	0.1	0.2	1.3	-0.1	0.3	1.1	-0.5	0.0	0.2	-0.2	-0.1
Supplements: Calcium	2.0	2.2	5.6	0.7	0.1	1.6	-2.1	0.6	-1.8	-1.2	-2.4
Basal cell carcinoma (self-reported)	0.5	0.6	3.7	1.9	0.8	0.1	-0.4	0.6	0.1	-0.2	0.1
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.0	1.4	0.4	1.3	-0.9	0.4	0.1	0.6	-0.3
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	4.5	0.0	-1.0	-1.0	2.0	-0.9	2.1	1.4	1.8
Heart disease (siblings)	2.5	3.1	6.1	-0.8	-1.4	-1.1	2.0	-0.6	2.4	2.2	2.5
Alcohol drinker status: Previous	0.3	0.4	0.7	-0.4	-0.6	-0.1	-0.7	-0.6	-0.6	0.9	-0.7
Pack years of smoking	2.3	3.4	11.3	1.3	-0.3	3.4	-1.7	1.9	-1.5	-1.7	-1.5
Impedance of whole body	0.7	3.6	11.8	-1.2	-3.3	-0.2	0.2	-3.4	-1.1	1.5	-1.0
Leg fat mass (left)	0.2	0.9	1.8	0.0	-0.9	-1.0	1.1	-0.6	1.3	0.7	1.2
Arm predicted mass (left)	0.7	3.6	7.0	-2.2	0.8	-1.9	2.4	0.2	2.6	1.2	2.4