Hub : Genes

IGFALS

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1560 0.0440 9.5e-06 0.008 0.048 0.033 0.047 0.012 3.1e-02 1.5e-06 5.5e-05 2.0e-06 1.1e-02
2 METSIM Adipose 0.0751 0.0312 4.0e-04 0.032 0.012 0.011 0.014 0.010 1.4e-05 6.1e-03 7.6e-03 2.6e-03 8.8e-03
3 ROSMAP Brain Pre-frontal Cortex 0.1311 0.0331 8.0e-10 0.115 0.079 0.088 0.104 0.108 1.4e-14 2.1e-10 2.3e-11 2.8e-13 9.2e-14
4 TCGA Breast Invasive Carcinoma 0.0399 0.0227 7.2e-06 0.025 0.027 0.030 NA 0.025 5.8e-06 2.5e-06 6.6e-07 NA 4.7e-06
5 TCGA Brain Lower Grade Glioma 0.0985 0.0549 2.8e-04 -0.001 0.028 0.020 NA 0.010 4.2e-01 3.7e-04 2.0e-03 NA 2.1e-02
6 TCGA Lung Adenocarcinoma 0.0941 0.0803 7.7e-07 0.080 0.057 0.050 NA 0.073 1.3e-09 3.1e-07 1.7e-06 NA 6.6e-09
7 TCGA Rectum Adenocarcinoma 0.3650 0.1620 5.4e-03 0.020 0.045 0.043 NA 0.012 1.1e-01 3.3e-02 3.5e-02 NA 1.6e-01
8 TCGA Thyroid Carcinoma 0.3650 0.0950 0.0e+00 0.428 0.410 0.395 NA 0.421 3.4e-45 9.3e-43 6.9e-41 NA 2.8e-44

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.8 1.3 4.2 0.5 0.2 0.5 -0.8 1.0 -1.4 -2.1 -1.4
Bipolar Disorder or Schizophrenia 2.2 5.2 10.8 2.6 0.9 1.5 -2.0 2.6 -2.2 -3.3 -2.3
Depressed Affect (Nagel 2018) 2.0 4.2 9.5 0.5 1.1 1.3 -2.8 0.3 -3.0 -1.9 -3.1
Depression (Nagel 2018) 1.1 1.6 7.3 -0.3 1.4 0.6 -0.9 2.7 0.1 -1.5 -0.4
Intelligence (Savage-Jansen 2018) 0.4 1.3 8.7 0.2 0.1 -3.0 0.3 0.1 0.2 1.1 0.0
Neuroticism (Nagel 2018) 0.5 1.1 3.4 -0.3 0.6 0.1 -1.6 -0.2 -1.8 -0.2 -1.6
Schizophrenia (2018) 2.1 4.5 9.5 3.1 1.0 1.5 -1.9 2.6 -1.7 -2.6 -1.8
Schizophrenia vs Biploar Disorder 0.3 0.4 3.0 0.1 1.7 -0.1 0.1 0.4 0.4 0.1 0.3
Worry (Nagel 2018) 0.3 0.6 1.4 -0.9 0.3 -0.9 -0.4 -0.8 -0.6 1.2 -0.4
Alzheimer’s Disease (in mother) 0.4 0.4 1.8 -0.5 -0.1 -1.3 -0.2 -1.1 -0.2 0.3 -0.4
Alzheimer’s Disease (in father) 0.9 1.0 2.9 1.7 -1.7 0.6 -0.7 -0.1 -0.6 -0.3 -0.8
Alzheimer’s Disease (including proxy) 0.2 0.3 0.7 0.3 -0.9 -0.8 -0.2 -0.9 -0.4 0.5 -0.2
Crohns Disease (2017) 0.5 1.1 2.4 -0.8 -0.2 -0.9 1.2 0.9 1.4 0.8 1.6
Irritable Bowel Disease (IBD) 0.6 1.4 2.5 -1.3 -1.1 -1.4 1.0 0.1 1.2 1.2 1.6
Ulcerative Colitis (UC) 0.2 0.5 1.3 -0.8 -1.1 -0.5 0.4 -0.5 0.3 0.5 0.9
Major Depression (MDD) 0.1 0.2 0.4 0.0 0.0 0.0 0.7 0.4 0.5 0.4 0.6
Reaction Time 1.4 2.6 6.4 -1.4 -2.5 -1.5 1.5 -1.3 1.9 1.3 1.1
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.9 0.2 0.5 -1.4 -1.3 0.8 -0.9 0.2 -0.9
Breast Cancer 0.3 0.8 2.4 -0.9 -1.6 -0.8 0.4 -1.2 0.1 0.8 0.6
Ovarian Cancer 2.5 3.4 6.0 0.9 1.7 1.9 -1.9 1.4 -1.8 -2.4 -2.1
Prostate Cancer 4.4 6.1 8.9 1.7 1.2 2.8 -2.9 1.5 -3.0 -2.9 -3.0
Age at First Birth 0.2 0.4 0.6 -0.2 0.7 -0.3 -0.2 0.7 0.8 0.8 0.5
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.6 1.7 0.6 -0.2 0.6 0.8 0.4 0.9 1.0 1.3
Coronary Artery Disease (CAD) 0.2 0.2 0.6 -0.0 0.8 -0.5 -0.0 0.8 0.2 0.3 -0.2
Crohns Disease (2012) 0.1 0.2 0.5 -0.4 -0.7 0.3 -0.3 0.2 -0.4 0.6 -0.1
Mean Putamen Volume 2.8 3.2 5.0 1.3 2.2 0.7 -1.9 1.0 -2.2 -2.2 -2.0
Fasting Glucose 0.7 0.9 2.5 0.7 0.7 0.3 -1.6 0.3 -1.3 -0.3 -1.2
HbA1C 0.4 0.5 1.0 -0.3 0.7 -0.0 -0.8 -0.1 -1.0 -0.9 -0.8
HDL Cholesterol 0.4 0.6 2.0 -0.0 1.4 -0.6 -0.5 0.9 -0.5 -0.9 -0.3
LDL Cholesterol 0.9 1.4 3.4 1.2 -0.7 0.7 -1.2 -0.9 -1.7 -0.7 -1.8
Lupus 0.5 0.7 1.5 1.0 -0.7 -0.7 0.4 1.2 1.0 -0.9 0.6
Neuroticism (2016) 0.5 0.8 2.7 0.5 1.6 0.3 -1.0 0.3 -1.0 -0.6 -0.9
Primary Biliary Cirrhosis 0.4 0.5 1.6 -0.2 0.5 1.3 -0.7 1.1 -0.1 -0.7 -0.5
Rheumatoid Arthritis 1.3 1.8 5.9 -0.5 0.5 -0.6 1.4 1.1 2.4 0.4 2.2
Schizophrenia (2014) 2.4 5.4 9.7 2.6 2.0 2.0 -2.2 2.7 -1.4 -3.1 -2.2
Triglycerides 1.4 2.3 5.0 1.4 -0.2 2.2 -1.8 -0.5 -1.8 -0.8 -2.1
Type 2 Diabetes (T2D) (2012) 0.3 0.4 0.7 -0.9 -0.3 -0.4 -0.8 -0.7 -0.7 -0.0 -0.8
Ulcerative Colitis 0.1 0.2 0.5 0.2 -0.5 -0.2 0.0 -0.3 -0.5 0.7 0.7
Blood Eosinophil Count 0.4 2.9 11.6 -2.4 -1.2 -0.7 1.1 -3.4 0.1 1.6 -0.0
Blood Platelet Count 0.8 9.8 22.2 -3.9 -4.7 -3.1 2.3 -3.4 1.9 3.0 1.7
Blood Red Count 0.5 5.0 12.5 0.3 -1.3 -2.6 1.7 -1.2 2.6 3.5 2.9
Blood White Count 0.9 6.7 16.7 -4.1 -2.0 -3.0 2.6 -2.6 1.0 2.7 1.5
Heel T-Score 0.6 4.9 12.6 3.5 2.3 1.6 -2.8 1.2 -1.4 -2.0 -1.8
BMI 0.1 0.7 3.3 0.4 0.9 -1.8 -0.0 0.6 0.7 -0.1 0.4
Height 1.0 19.1 68.1 -8.2 -1.8 -4.0 4.0 -3.7 3.2 3.8 3.2
Waist Hip Ratio (WHR) 0.2 1.1 4.2 -2.0 0.1 -0.5 -0.5 -1.7 -0.5 0.6 -0.8
Systolic Blood Pressure 2.1 10.4 23.9 -3.0 -4.2 -3.2 2.0 -3.0 2.1 4.9 2.0
Smoking Status 0.4 1.0 3.2 -1.8 1.7 0.1 -0.5 0.9 0.0 -0.7 -0.4
Allergy or Eczema 0.2 0.5 1.4 0.3 0.7 -0.7 -0.8 0.0 -1.2 0.1 -0.9
Cardiovascular Disease 2.9 9.7 19.6 -2.8 -3.1 -3.1 2.5 -2.1 3.4 4.4 3.0
Hypothyroidism (self reported) 1.8 4.1 7.2 -2.5 -0.1 -2.3 1.8 -1.8 2.1 2.7 1.8
Respiratory disease 0.4 1.0 2.4 0.7 0.3 -1.1 -0.9 -0.9 -1.5 0.1 -1.6
Type 2 Diabetes (T2D) (2018) 0.7 1.3 3.8 0.3 0.4 -0.1 -2.0 0.4 -1.6 -0.3 -1.8
Lung FEV1/FVC ratio 1.1 5.7 11.3 -3.2 1.0 -2.7 2.3 -1.3 3.4 2.1 2.2
Lung FVC 1.1 5.8 20.4 -0.7 -4.5 -0.9 2.5 -2.2 0.9 2.8 2.2
Neuroticism 0.1 0.3 1.0 -0.3 0.4 -0.6 -1.0 -0.1 -0.5 0.6 -0.6
Chronotype (morning person) 3.2 7.4 15.6 2.3 3.8 2.8 -1.6 4.0 -1.3 -3.3 -0.8
Hair Pigment 0.0 0.9 2.4 1.5 -0.2 -0.4 1.1 0.4 1.2 0.6 1.2
Tanning 0.4 4.9 9.9 1.9 2.3 3.0 -1.7 3.1 -0.7 -2.7 -1.0
Hand grip strength (left) 0.5 1.3 3.5 -1.3 0.9 0.5 -0.8 0.5 -1.9 -1.1 -1.3
Number of treatments/medications taken 0.2 0.4 1.2 0.6 -0.3 0.1 -0.7 -0.0 -1.1 0.8 -0.8
Average weekly spirits intake 0.8 1.0 1.5 -1.1 -0.9 -1.2 1.1 -1.0 0.8 0.9 0.7
Sensitivity / hurt feelings 0.8 1.4 3.7 -0.5 0.4 1.0 -1.3 -0.9 -1.8 0.2 -1.9
Frequency of depressed mood in last 2 weeks 0.7 0.9 2.4 -0.3 0.9 1.4 -0.6 1.6 -0.4 -1.1 -0.5
Hearing difficulty/problems: Yes 2.1 3.2 7.6 2.5 0.8 -0.8 -2.8 1.8 -1.7 -1.3 -1.7
Relative age of first facial hair 1.3 2.7 10.6 -0.3 3.3 0.4 -0.9 2.1 -0.9 -2.0 -0.7
Other serious medical condition/disability diagnosed by doctor 1.0 1.2 3.9 0.1 -0.2 -1.7 1.1 0.0 2.0 0.9 1.1
Ever used hormone-replacement therapy (HRT) 1.6 2.0 6.9 2.6 1.4 0.9 0.1 1.7 0.8 -1.6 -0.4
Ever had hysterectomy (womb removed) 1.4 1.6 3.2 1.1 1.8 1.4 -1.0 1.4 -0.6 -1.0 -1.3
Systolic blood pressure, automated reading 1.8 5.3 15.0 -1.0 -2.9 -2.2 1.5 -1.6 1.9 3.9 2.1
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 3.1 0.5 1.0 -0.9 -0.0 1.8 0.9 -0.4 0.4
Angina 0.1 0.1 0.3 -0.0 0.1 0.5 -0.2 0.4 0.1 0.3 -0.2
Medication for hormone replacement therapy 0.2 0.2 1.2 0.5 1.1 -0.2 0.1 0.1 -0.1 0.1 0.1
Vitamin and mineral supplements 0.5 0.6 1.4 1.0 0.6 0.4 1.2 0.6 0.8 -0.6 0.9
Supplements: Zinc 0.4 0.4 1.2 0.7 -0.4 0.3 -0.9 -0.2 -0.7 0.1 -1.1
Medication: Co-codamol 1.4 1.6 4.0 0.1 -1.4 -1.2 -0.7 -1.5 -2.0 0.8 -1.4
Medication: Metformin 0.9 1.2 2.4 1.6 1.5 -1.1 -1.1 0.9 -1.1 0.1 -0.9
Diabetes (father) 3.1 3.9 11.4 0.3 0.9 1.5 -2.4 -0.7 -3.4 -0.8 -3.1
Diabetes (mother) 1.0 1.3 2.9 0.1 0.6 1.6 -0.7 -0.6 -1.2 -1.5 -1.7
Severe depression (siblings) 1.7 1.9 3.8 0.3 0.6 1.6 -1.6 0.8 -1.5 -1.8 -1.9
Pack years adult smoking proportion 2.1 3.3 10.2 1.2 0.1 3.2 -1.7 2.2 -1.4 -1.8 -1.3
Impedance of leg (right) 1.5 7.4 20.2 -2.6 -4.5 -1.0 2.3 -3.9 1.1 2.9 1.0
Leg fat-free mass (left) 0.2 0.9 3.4 -0.8 1.9 -0.8 0.8 0.4 1.0 -0.4 0.6
Trunk fat percentage 0.2 0.8 2.2 0.8 -1.5 -0.5 -0.3 -1.3 -0.7 0.1 -0.8
Hand grip strength (right) 0.2 0.6 3.6 -1.9 0.6 0.0 -0.2 0.4 -0.8 -0.5 -0.3
Townsend deprivation index at recruitment 2.0 2.8 6.7 -1.7 -2.6 -0.5 1.8 -1.9 1.4 1.4 1.4
Current tobacco smoking 0.4 0.7 1.7 -0.9 1.3 0.3 -0.6 1.2 0.4 -0.8 -0.0
Average weekly fortified wine intake 3.2 3.7 7.8 -1.1 -2.8 -2.3 1.5 -2.0 1.7 2.3 1.1
Maternal smoking around birth 0.2 0.3 1.2 -1.1 0.8 0.6 -0.1 0.3 -0.3 -0.3 0.2
Fed-up feelings 1.5 2.8 6.3 0.7 1.1 1.4 -2.5 0.9 -1.9 -1.7 -2.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 5.5 0.0 1.4 1.4 -1.1 2.3 -0.3 -1.6 -0.7
Relative age voice broke 0.5 0.8 3.8 -1.9 0.9 -0.4 0.6 -0.5 0.5 0.3 0.7
Taking other prescription medications 0.3 0.4 0.9 0.6 -0.5 -0.6 0.1 -1.0 -0.6 0.7 -0.6
Age when periods started (menarche) 0.3 0.6 1.4 -1.2 -0.6 -0.9 1.0 -0.4 1.0 0.5 0.5
Bilateral oophorectomy (both ovaries removed) 0.7 0.9 2.5 0.9 1.0 1.6 -0.4 0.8 0.7 -0.9 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 2.3 5.1 9.6 2.0 2.3 1.0 -2.4 1.4 -2.5 -3.1 -2.7
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.7 0.4 0.6 -0.5 1.2 0.5 1.3 -0.0 1.3
Qualifications: CSEs or equivalent 0.5 0.6 2.7 -0.6 -0.6 0.5 0.3 -1.6 -0.4 -0.3 -1.0
Serious illness, injury or assault to yourself 2.0 2.4 6.6 0.5 -0.7 1.3 -2.4 -0.1 -2.0 -0.6 -2.6
High blood pressure 2.2 6.1 11.2 -3.0 -2.1 -2.8 1.6 -1.6 2.3 3.3 2.3
Hayfever, allergic rhinitis or eczema 0.4 0.8 3.1 -1.2 0.2 -1.8 -0.3 -0.9 -0.5 0.6 -0.8
Multivitamins +/- minerals 0.6 0.7 2.5 -0.3 0.2 0.6 -1.6 -0.1 -1.0 0.4 -1.2
Stomach or abdominal pain in last month 2.7 3.4 5.6 -1.4 -2.4 -1.9 1.9 -2.2 1.3 1.9 1.5
Supplements: Glucosamine 1.1 1.4 3.7 1.8 0.7 -0.1 -1.9 0.9 -1.1 -0.8 -1.3
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 3.6 -0.9 -1.2 -0.9 1.4 -1.5 1.4 1.9 1.4
Medication: Atenolol 1.5 1.9 4.8 -1.2 -1.5 -1.4 0.0 0.0 1.5 2.2 1.5
Medication: Levothyroxine sodium 0.6 0.9 1.8 -1.4 0.7 -1.1 0.8 -1.0 0.9 1.1 0.5
Sitting height 0.2 1.2 3.5 -1.9 -1.1 -0.4 0.9 -1.7 0.1 1.1 -0.3
Chronic bronchitis/emphysema (father) 0.2 0.3 1.2 1.1 0.1 0.5 -0.3 0.5 0.2 0.6 0.2
High blood pressure (mother) 0.1 0.2 0.5 0.5 0.2 -0.1 -0.4 0.7 0.3 -0.6 0.2
Body mass index (BMI) 0.1 0.6 2.4 1.5 0.6 -0.1 -0.5 1.1 0.1 -0.7 -0.1
Impedance of leg (left) 1.7 8.3 21.3 -2.9 -4.6 -1.2 2.4 -3.8 1.5 3.2 1.6
Leg predicted mass (left) 0.2 0.9 3.9 -0.8 2.0 -0.8 0.8 0.6 0.9 -0.4 0.6
Trunk fat mass 0.1 0.4 1.1 0.1 -0.9 -0.9 0.5 -1.0 0.2 0.4 0.1
Waist circumference 0.4 1.4 3.3 -1.0 -0.8 -1.8 1.1 -1.3 1.1 1.1 0.9
Number of incorrect matches in round 1.3 2.2 8.6 -1.9 -0.4 -2.9 1.5 -0.7 1.1 0.7 1.0
Past tobacco smoking 0.2 0.4 1.0 0.8 -0.9 0.2 -1.0 0.0 -0.7 0.4 -0.2
Alcohol usually taken with meals 0.7 1.1 2.7 1.6 0.3 0.7 -0.9 -0.5 -1.5 -1.0 -1.0
Nervous feelings 0.6 1.1 3.5 -0.3 0.6 0.3 -1.5 -0.6 -1.9 0.7 -1.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.9 -1.0 -0.2 0.3 -0.9 -0.3 -0.8 0.4 -0.7
Hearing difficulty/problems with background noise 0.9 1.4 5.2 0.2 0.4 -0.8 -2.3 0.9 -1.3 -0.1 -1.5
Hair/balding pattern: Pattern 2 0.2 0.2 1.0 0.2 -0.6 1.0 -0.0 -0.3 0.3 0.2 -0.1
Had menopause 0.2 0.2 0.8 -0.3 0.1 0.4 -0.9 -0.2 0.5 0.2 -0.7
Had other major operations 1.0 1.2 6.0 -0.9 -0.7 -2.4 0.1 -0.7 0.4 1.4 -0.1
Forced vital capacity (FVC) 1.8 7.1 13.6 -2.5 -3.7 -2.0 3.0 -2.6 1.9 2.9 2.4
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 3.3 1.4 0.6 0.2 -1.7 0.6 -1.5 -1.4 -1.8
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 1.2 -1.0 -0.8 -0.8 0.9 -0.1 0.9 1.1 1.1
Qualifications: None of the above 1.1 2.3 7.9 1.2 0.3 2.8 -0.8 1.4 -1.5 -1.7 -1.0
Financial difficulties in last 2 years 0.5 0.6 1.3 -0.7 -1.0 0.5 -0.2 -1.0 -0.9 0.0 -1.1
Mouth/teeth dental problems 0.4 0.6 1.7 -1.3 -0.4 0.8 0.9 -0.5 0.2 -1.0 0.4
Heart attack 0.5 0.6 2.0 1.4 0.3 1.1 -0.9 0.3 -0.1 0.6 -0.5
Allergy 0.4 1.0 3.1 0.7 0.6 1.5 -0.2 1.8 -0.0 -1.1 0.7
Pain all over the body in last month 0.9 1.0 2.1 -0.4 0.8 1.0 -1.2 0.2 -1.5 -0.8 -1.4
Diabetes (self-reported) 0.6 0.9 2.0 1.4 -0.1 -0.3 -1.4 -0.3 -1.2 0.2 -1.4
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.7 -0.6 0.2 -0.8 -0.3 -0.3 0.1 -0.3 -0.5
Medication: Ramipril 0.7 0.9 1.7 -0.9 0.1 -1.2 -1.3 0.1 -1.3 0.8 -0.8
Medication: Simvastatin 0.3 0.4 1.1 0.4 0.8 0.8 0.1 0.6 0.9 -0.1 1.0
Fluid intelligence score 0.5 0.9 2.3 0.9 0.1 -1.5 -1.3 1.1 -1.1 0.4 -0.6
Illnesses of siblings 1.7 2.4 4.8 0.1 1.2 1.6 -1.7 0.6 -2.0 -1.8 -2.2
Neuroticism score 0.3 0.7 1.1 -0.8 0.3 -0.6 -0.9 -0.9 -0.9 1.0 -1.0
Weight 0.2 0.9 1.7 -1.0 0.1 -1.3 1.3 -0.4 1.2 0.6 0.9
Impedance of arm (right) 0.7 3.1 9.2 0.1 -2.4 0.5 -1.0 -3.0 -2.1 0.3 -2.1
Arm fat percentage (right) 0.3 1.2 3.8 1.9 -0.7 0.0 -1.2 -0.3 -1.1 -0.7 -1.3
Trunk fat-free mass 0.8 4.6 9.1 -3.0 1.1 -1.8 2.7 -0.2 2.8 1.3 2.5
Hip circumference 0.3 1.5 4.4 -0.7 -1.0 -2.1 1.4 -0.7 1.4 0.9 1.0
Time employed in main current job 0.3 0.4 1.3 0.4 1.1 0.6 -1.0 0.5 -0.2 -0.4 0.1
Alcohol intake versus 10 years previously 2.5 3.8 8.8 -2.0 -1.5 -1.4 3.0 -2.4 1.2 2.0 1.5
Father’s age at death 1.4 1.9 7.6 -0.8 -1.9 -1.0 0.2 -2.8 -0.5 1.3 -0.6
Worrier / anxious feelings 1.2 2.4 8.2 -0.8 -1.7 -1.7 0.7 -1.7 0.6 2.9 0.4
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.3 -0.4 -0.2 0.1 0.4 -0.4 0.4 0.7 1.1
Falls in the last year 0.2 0.2 0.6 -0.7 -0.3 -0.1 0.2 -0.6 0.8 -0.4 0.1
Hair/balding pattern: Pattern 3 0.2 0.3 0.8 -0.9 -0.1 -0.2 0.6 -0.2 0.6 0.6 0.5
Number of live births 1.5 2.2 5.0 1.6 -0.3 0.3 -2.0 0.7 -2.1 -0.9 -2.2
Forced expiratory volume in 1-second (FEV1) 2.0 6.6 10.1 -2.7 -2.8 -2.2 3.2 -2.4 2.2 2.5 2.3
Pulse rate 1.0 1.6 3.4 -1.1 -1.8 0.5 1.1 -1.6 1.2 1.4 1.1
Happiness 0.9 1.1 4.3 -2.1 1.9 -0.6 0.1 0.2 0.2 0.2 -0.1
Noisy workplace 0.6 0.7 2.2 0.6 1.3 0.5 -1.0 1.5 0.1 -0.4 -0.1
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.3 0.1 0.9 -1.1 -0.4 0.2 -0.5 0.3 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.9 -0.1 0.0 -1.2 1.1 -0.1 1.7 -0.2 0.9
Mouth/teeth dental problems: Dentures 1.7 2.8 6.7 2.0 1.0 1.4 -2.6 1.7 -1.5 -1.5 -1.3
Asthma 0.5 0.9 3.1 -0.2 -0.5 -0.9 -0.3 -1.8 -1.1 0.4 -1.4
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.9 -0.3 0.0 -0.9 0.5 -0.3 0.6 0.7 0.5
Medication: Cholesterol lowering 0.1 0.2 1.1 1.0 -0.0 -0.0 0.2 0.1 -0.1 -0.3 0.1
Depression (self-reported) 1.1 1.3 3.2 1.4 0.8 0.5 -0.7 1.7 -0.7 -1.8 -0.7
Medication: Lansoprazole 1.6 1.8 5.5 0.5 0.3 0.8 -2.2 0.2 -2.3 -0.4 -1.7
Prospective memory result 0.5 0.6 1.5 1.1 -0.2 1.2 -0.8 0.1 -0.3 -0.3 -1.0
Lung cancer (father) 0.3 0.3 0.7 0.4 -0.2 0.8 0.6 -0.0 0.7 0.4 0.7
Illnesses of mother 0.6 0.7 3.0 -0.9 -0.9 -0.4 0.1 -0.7 0.2 1.7 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 2.7 8.5 12.8 -3.2 -2.9 -2.7 3.6 -2.8 2.1 3.2 2.6
Pulse wave Arterial Stiffness index 0.6 0.7 2.5 0.4 -1.6 0.7 -0.1 -1.3 -0.5 0.2 -0.7
Impedance of arm (left) 0.7 3.3 8.8 0.1 -2.2 0.3 -1.1 -3.0 -2.4 0.1 -2.4
Arm fat mass (right) 0.1 0.3 0.8 0.9 -0.0 -0.7 -0.4 -0.2 -0.3 -0.4 -0.6
Trunk predicted mass 0.8 4.6 8.7 -3.0 1.0 -1.9 2.7 -0.2 2.8 1.4 2.5
Standing height 1.1 10.8 31.7 -5.6 -1.1 -2.9 3.8 -3.5 2.5 2.8 2.1
Length of working week for main job 2.2 2.4 6.4 -1.4 -0.7 -1.2 2.0 -0.2 2.5 0.8 2.1
Exposure to tobacco smoke at home 0.4 0.5 1.3 0.2 -0.2 -1.1 1.0 -0.2 0.5 1.0 0.6
Breastfed as a baby 0.9 1.1 2.7 -1.2 -1.3 -1.0 0.3 -1.6 -0.2 1.3 0.5
Tense / ‘highly strung’ 0.1 0.2 0.5 0.3 0.6 -0.4 -0.5 0.2 -0.4 0.2 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 3.1 1.0 0.6 0.1 -1.1 -0.5 -1.8 -0.7 -1.4
Hair/balding pattern: Pattern 4 0.4 1.0 2.0 1.2 1.3 0.8 -0.7 1.2 -0.7 -1.4 -0.0
Birth weight of first child 1.4 2.5 5.3 2.2 0.4 -0.6 -2.3 1.9 -1.4 -0.9 -1.8
Peak expiratory flow (PEF) 0.2 0.6 2.0 -0.5 0.7 -0.5 1.4 0.3 1.0 -0.0 0.7
Pulse wave reflection index 0.3 0.4 1.3 0.4 -0.6 0.1 0.7 -1.1 -0.7 0.3 -0.3
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.3 -0.7 0.2 0.8 -0.5 0.1 -1.0 -1.1 -0.9
Loud music exposure frequency 2.5 2.7 5.2 0.3 2.2 1.6 -1.6 2.3 -1.1 -2.1 -1.0
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.6 -1.2 -0.5 -1.0 0.2 -1.1 0.0 1.3 0.1
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.4 1.0 0.0 -0.6 -0.2 -0.0 0.4 1.2 -0.1
Blood clot in the leg (DVT) 1.5 2.0 4.5 0.1 -1.0 -1.2 2.0 -0.8 2.1 1.2 1.7
Medication: Paracetamol 0.5 0.8 2.6 0.3 0.1 0.8 -0.8 -0.8 -1.6 0.5 -1.2
Headache pain in last month 0.4 0.8 2.7 -0.2 -1.2 -1.6 0.3 -0.7 -0.3 1.1 -0.1
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.3 0.0 1.1 0.3 -0.4 0.6 -0.1 -0.7 -0.2
Glaucoma (self-reported) 1.3 1.5 4.5 -1.1 -2.1 -0.8 0.2 -1.9 -0.3 1.3 -0.4
Gout (self-reported) 0.8 1.2 3.5 0.2 1.9 -0.3 0.6 1.7 1.2 -0.1 1.0
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 4.9 -2.1 0.4 -1.9 1.4 -1.3 1.6 2.2 1.7
Medication: Amlodipine 1.9 2.6 4.8 -2.2 -1.6 -1.9 1.0 -0.7 1.4 2.2 1.4
Medication: Ventolin 100micrograms inhaler 0.6 0.8 3.4 -0.1 -0.6 -0.6 -0.4 -0.6 -1.8 0.1 -1.2
Birth weight 1.7 3.6 6.3 1.2 2.0 2.0 -2.2 2.5 -1.5 -2.0 -1.6
Chronic bronchitis/emphysema (mother) 2.1 2.5 4.3 1.1 1.2 1.5 -1.4 1.6 -1.8 -2.1 -1.6
High blood pressure (siblings) 1.3 1.9 4.1 1.0 0.6 -1.6 1.5 0.8 1.9 0.8 2.0
Forced vital capacity (FVC), Best measure 2.0 7.2 10.5 -2.8 -3.2 -2.2 3.1 -2.7 1.6 3.2 2.4
Body fat percentage 0.2 0.7 2.5 0.9 -1.6 -0.4 -0.2 -1.1 -0.4 0.2 -0.5
Leg fat percentage (right) 0.4 1.3 4.3 0.2 -2.1 -0.6 1.2 -1.2 1.0 1.1 0.9
Arm fat-free mass (right) 0.7 3.7 6.4 -2.3 0.6 -2.1 2.4 -0.2 2.5 1.5 2.2
Exposure to tobacco smoke outside home 0.2 0.3 0.9 -0.5 1.0 0.6 0.4 0.4 0.2 0.1 0.5
Comparative body size at age 10 1.3 3.7 10.5 -0.1 1.1 -0.5 1.7 2.4 3.2 0.1 3.0
Number of full brothers 1.4 1.7 4.7 -0.2 -2.2 -0.3 1.3 -1.8 0.5 1.4 1.3
Worry too long after embarrassment 1.6 2.6 4.6 -1.7 -0.3 -2.1 1.7 -0.1 1.8 1.7 2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.7 0.2 -0.4 -0.7 -0.5 -0.3 -0.8 0.3 -0.3
Wheeze or whistling in the chest in last year 0.4 0.8 2.4 0.4 -0.8 -0.4 -1.0 0.1 -1.6 -0.3 -1.3
Number of children fathered 1.1 1.3 4.1 2.0 -0.5 1.3 -0.9 1.5 -0.4 -0.7 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.5 0.9 -0.5 -0.4 -1.2 0.1 -1.1 -0.7 -1.2
Age at first live birth 2.3 4.0 13.3 -0.6 0.2 -3.7 1.6 -0.5 2.5 2.2 2.1
Pulse wave peak to peak time 0.6 0.8 2.2 -0.6 1.5 -0.9 0.3 1.1 0.7 -0.1 0.8
Health satisfaction 0.5 0.6 2.8 -0.7 -0.1 -0.6 0.3 -0.3 1.0 1.7 0.5
Shortness of breath walking on level ground 0.3 0.3 1.0 -0.2 -0.5 1.0 -0.6 0.3 -0.2 0.8 -0.2
Qualifications: College or University degree 0.2 0.7 3.2 -0.6 1.1 -1.8 -0.5 -0.0 -0.4 0.3 -0.4
Eye problems/disorders: None of the above 0.6 0.7 3.6 0.7 -0.2 -0.4 0.9 -0.1 0.7 0.7 1.9
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.6 0.3 -0.6 0.8 1.1 0.7 1.6 -0.5 1.4
Emphysema/chronic bronchitis 0.4 0.4 1.9 0.8 0.4 0.5 0.2 1.4 0.3 -0.1 0.2
Medication for pain relief, constipation, heartburn 0.3 0.5 1.9 -0.7 0.2 0.1 0.0 1.2 0.3 -1.4 0.1
Neck or shoulder pain in last month 0.5 0.7 1.2 -0.9 0.7 -0.6 1.1 0.1 1.1 0.6 1.1
Medication: Blood pressure 0.5 0.9 2.6 -0.5 -1.6 -0.8 0.3 -1.2 0.1 1.4 0.3
Angina (self-reported) 0.1 0.1 0.5 0.2 0.0 0.7 -0.3 0.2 -0.2 0.1 -0.4
Migraine (self-reported) 0.6 0.7 4.2 0.4 0.4 2.0 -0.2 0.9 0.5 -0.5 0.3
Medication: Ibuprofen 0.3 0.3 1.3 -0.7 0.5 -1.1 -0.0 -0.1 0.4 0.9 -0.1
Medication: Allopurinol 1.5 2.0 6.8 1.5 2.6 0.5 -0.6 2.0 0.4 -1.4 -0.1
Medication: Omeprazole 0.8 0.9 2.5 -0.1 -0.3 -0.9 1.4 -1.6 0.8 0.9 0.8
Medication: Seretide 50 evohaler 0.7 0.9 2.3 1.5 1.1 0.7 -1.2 0.5 -0.3 -0.6 -0.8
Mean time to correctly identify matches 2.0 3.8 7.7 -1.3 -2.2 -1.9 2.1 -1.0 2.8 1.7 2.2
Heart disease (mother) 0.6 0.7 2.1 0.8 1.2 -0.6 -0.7 1.4 0.5 -0.4 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 1.0 0.3 0.8 -1.0 0.3 -0.2 -0.0 0.1 0.5
Whole body fat mass 0.1 0.4 0.8 0.2 -0.9 -0.8 0.5 -0.8 0.5 0.3 0.2
Leg fat mass (right) 0.2 0.8 1.1 0.2 -1.1 -0.9 1.1 -0.8 1.1 0.7 0.9
Arm predicted mass (right) 0.6 3.3 6.8 -2.0 1.1 -1.9 2.2 0.4 2.6 1.1 2.2
Pulse rate, automated reading 0.1 0.4 1.3 0.2 -1.1 0.9 0.7 -0.8 -0.1 -0.4 -0.1
Alcohol intake frequency. 0.2 0.5 1.9 -0.5 -0.8 1.4 -0.3 -0.6 -0.9 0.3 -0.4
Comparative height size at age 10 0.6 3.4 8.8 -3.0 -0.1 -0.6 2.5 -2.5 1.7 1.2 1.4
Number of full sisters 0.9 1.1 2.5 1.0 -0.7 0.7 -1.0 -0.7 -1.6 -0.9 -1.5
Suffer from ‘nerves’ 1.1 1.7 4.2 -1.2 -0.8 -1.7 -0.0 -2.0 -0.8 1.8 -0.7
Overall health rating 0.2 0.5 1.7 -0.3 0.0 -0.9 0.0 0.6 1.3 0.6 0.8
Chest pain or discomfort 1.1 1.5 6.2 -0.4 -1.2 -1.0 0.6 -1.5 0.3 2.5 0.8
Had major operations 0.2 0.2 0.9 0.1 -0.9 -0.5 0.2 -0.4 -0.4 0.6 0.2
Age at last live birth 2.3 3.3 13.4 -1.0 -0.9 -3.7 1.4 -0.4 1.7 1.9 1.7
Family relationship satisfaction 0.6 0.7 2.4 -1.5 0.6 -1.2 0.9 0.3 0.7 -0.0 0.4
Leg pain on walking 0.3 0.4 0.9 -1.0 0.0 0.5 -0.5 -0.4 -0.8 0.7 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.7 1.3 0.1 0.8 0.1 0.2 0.3 -0.3 -0.3
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.8 1.0 1.2 -0.2 -0.7 0.6 -0.9 -1.3 -1.0
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.5 0.1 1.0 -0.8 -1.2 0.7 -1.2 -0.3 -0.5
Medication: Aspirin 0.2 0.3 1.0 1.0 -0.2 0.7 -0.6 -0.6 -0.4 0.3 -0.5
Supplements: Vitamin C 0.5 0.6 2.6 -0.4 -1.6 0.3 0.2 -1.5 0.0 0.2 0.0
Knee pain experienced in last month 0.2 0.3 1.0 1.0 0.4 -0.5 0.1 0.4 0.6 -0.6 0.3
Hypertension (Self-reported) 3.3 9.2 16.7 -3.3 -2.8 -3.2 2.3 -2.0 3.0 4.1 3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.3 0.6 0.6 1.1 -1.0 -0.8 -1.1 -0.5 -1.1
Illnesses of father: Heart disease 2.7 3.7 12.0 -0.7 0.6 -0.3 1.7 1.3 3.3 1.1 3.5
Illnesses of siblings: Diabetes 0.2 0.3 0.6 0.2 -0.4 -0.5 -0.7 -0.8 -0.2 0.7 -0.4
Smoking status: Previous 0.5 0.8 2.9 -0.9 -0.1 0.1 1.7 -0.8 1.0 0.2 0.8
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.0 5.3 -2.3 -0.4 -1.6 1.7 -1.1 1.3 1.0 1.1
Whole body fat-free mass 0.5 2.7 4.8 -2.1 1.4 -1.6 2.0 0.1 2.2 0.7 1.8
Leg fat-free mass (right) 0.2 1.1 5.0 -0.7 2.2 -0.7 0.6 0.9 0.9 -0.6 0.7
Arm fat percentage (left) 0.3 1.1 3.3 1.8 -0.7 -0.2 -1.2 -0.3 -1.2 -0.7 -1.4
Average weekly red wine intake 0.8 1.3 2.9 0.9 1.6 0.3 -0.8 1.7 -0.6 -1.6 -0.3
Handedness (chirality/laterality): Left-handed 3.8 4.6 9.4 1.7 3.1 -0.2 -2.4 2.6 -1.9 -2.1 -1.9
Mood swings 0.3 0.6 2.0 -0.5 0.1 -0.1 -0.9 -0.4 -1.4 -0.3 -1.1
Loneliness, isolation 1.3 1.8 3.1 1.4 0.9 0.8 -1.5 1.1 -1.3 -1.7 -1.8
Long-standing illness, disability or infirmity 0.5 0.8 2.1 1.0 -1.0 -0.2 -1.5 -0.1 -1.0 -0.1 -1.1
Ever had bowel cancer screening 0.5 0.6 1.3 0.9 -0.2 -0.7 0.6 0.9 0.9 -0.1 1.2
Diabetes diagnosed by doctor 0.8 1.4 4.0 1.4 0.5 -0.0 -2.0 0.3 -1.3 -0.1 -1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.4 0.0 -0.4 -1.0 0.9 0.1 1.2 -0.2 0.3
Friendships satisfaction 0.5 0.6 1.5 -0.6 -0.2 -1.2 0.6 -0.2 0.7 1.2 0.4
Qualifications: nursing, teaching 0.8 1.2 4.3 -0.7 -0.2 -2.1 0.3 -0.8 0.9 1.8 0.5
Commuting to job workplace: Walk 0.1 0.1 0.6 0.6 0.1 -0.7 0.2 0.3 0.2 -0.1 -0.3
Eye problems/disorders: Cataract 0.4 0.5 1.9 -0.5 0.8 -1.4 0.1 0.5 0.8 -0.2 0.1
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 4.2 -0.1 -1.1 -1.7 0.8 -1.4 -0.3 2.1 0.2
Medication for cholesterol 0.5 0.8 2.9 0.4 0.9 0.2 -0.1 0.4 -0.7 -1.7 -1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.5 -0.2 -0.3 -0.6 0.3 -0.7 0.1 0.7 -0.2
Back pain experienced in last month 0.5 0.7 2.5 -0.9 0.6 -0.1 -0.4 -0.3 -1.6 -0.7 -1.1
Mineral and other dietary supplements 0.9 1.1 3.5 0.2 -0.7 -0.9 1.9 -0.5 1.4 0.7 1.2
Breast cancer (self-reported) 0.3 0.4 1.0 -1.0 0.8 0.2 0.3 0.5 0.3 -0.8 -0.3
Asthma (self-reported) 0.5 1.1 4.0 -0.3 -0.6 -1.2 0.0 -2.0 -1.0 0.7 -1.1
Osteoporosis (self-reported) 0.7 0.9 3.3 0.5 1.8 0.8 -0.1 1.3 0.2 -1.1 0.1
Osteoarthritis (self-reported) 0.3 0.4 1.2 -0.1 1.1 -1.1 0.2 0.3 0.7 -0.4 0.4
Medication: Aspirin 0.3 0.4 1.3 1.2 0.4 0.4 -0.9 -0.0 -0.4 0.1 -0.5
Medication: Gliclazide 0.8 0.9 2.0 0.2 1.4 -0.3 -1.4 0.9 -1.2 0.1 -0.9
Illnesses of father: None of the above (group 1) 0.1 0.2 0.3 -0.3 0.5 -0.5 -0.0 -0.0 -0.5 -0.4 -0.6
Smoking status: Current 0.5 0.7 1.8 -0.9 1.3 -0.0 -0.5 1.3 0.4 -1.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.7 3.7 9.7 -0.1 -1.1 -1.2 3.1 -1.3 1.6 2.4 2.6
Whole body water mass 0.5 2.7 5.0 -2.2 1.3 -1.6 2.0 0.1 2.1 0.8 1.8
Leg predicted mass (right) 0.2 1.1 5.2 -0.7 2.3 -0.8 0.6 0.8 0.9 -0.5 0.6
Arm fat mass (left) 0.0 0.2 0.5 0.6 -0.1 -0.7 -0.3 -0.1 -0.1 -0.3 -0.4
Number of self-reported non-cancer illnesses 0.3 0.6 1.4 -0.4 0.7 -1.2 0.3 0.5 1.1 0.4 0.7
Average weekly champagne plus white wine intake 0.4 0.5 1.3 1.1 -0.4 -0.7 -0.3 -0.8 -0.3 -0.3 -1.1
Miserableness 1.5 2.5 6.9 -0.8 0.6 0.7 -1.3 -1.6 -2.4 -1.4 -2.6
Guilty feelings 0.2 0.3 1.1 0.1 -0.4 0.1 -0.2 0.0 0.6 1.0 0.6
Wears glasses or contact lenses 0.2 0.3 0.6 0.2 0.2 -0.3 -0.7 -0.3 -0.6 -0.6 -0.8
Ever taken oral contraceptive pill 0.5 0.5 1.2 -1.1 -0.1 0.5 -1.0 -0.2 -0.8 -0.4 -1.0
Hearing aid user 0.5 0.6 2.9 0.4 -1.7 -0.3 0.3 -0.7 0.6 0.9 0.3
Mother’s age at death 0.9 1.2 2.6 1.3 0.5 0.6 -1.0 1.5 -0.6 -1.6 -1.0
Financial situation satisfaction 0.1 0.1 0.4 -0.1 0.0 0.2 -0.3 -0.0 0.3 0.7 0.1
Tinnitus: Yes, now most or all of the time 1.1 1.3 4.2 0.8 1.0 2.0 -1.0 1.7 0.5 -0.8 0.3
Commuting to job workplace: Public transport 0.6 0.7 1.6 0.2 0.5 0.3 -1.3 0.1 -1.2 0.8 -1.2
Eye problems/disorders: Glaucoma 0.9 1.0 2.8 -0.9 -1.7 0.1 -0.3 -1.7 -0.9 0.0 -1.0
Medication: Blood pressure 2.2 4.1 7.3 -2.7 -1.8 -1.9 1.2 -1.2 2.1 2.6 2.2
Pain type(s) experienced in last month: Hip pain 0.6 0.8 2.1 0.6 0.6 0.1 -1.2 0.6 -1.4 -0.4 -1.2
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.1 -0.1 0.9 0.9 -1.0 0.8 -0.4 -0.8 -0.4
High cholesterol (Self-reported) 0.4 0.8 2.3 1.4 0.1 -0.1 0.5 0.8 1.5 0.1 1.0
Medication: Bendroflumethiazide 2.0 3.0 5.5 -1.4 -1.5 -0.6 2.2 -1.3 2.3 1.5 2.3
Medication: Paracetamol 0.7 1.1 3.3 0.8 0.1 1.0 -1.3 -0.3 -1.8 -0.1 -1.5
Medication: Lisinopril 1.3 1.7 4.8 -1.2 -0.9 -0.8 0.8 -2.2 0.7 1.9 1.2
Medication: Atorvastatin 0.4 0.5 2.7 1.6 -0.8 0.3 -0.1 0.2 -0.5 -0.2 -0.5
Illnesses of father: High blood pressure 0.2 0.2 0.6 -0.4 0.8 -0.1 0.1 0.4 0.8 0.1 0.4
Alcohol drinker status: Never 0.1 0.1 0.4 -0.6 0.2 -0.0 0.3 -0.4 0.6 0.0 0.2
Ever smoked 0.7 1.2 2.4 -0.7 1.2 -1.4 1.4 0.7 1.6 -0.2 1.0
Basal metabolic rate 0.4 2.3 4.0 -2.0 1.1 -1.6 1.9 -0.1 1.9 0.7 1.6
Leg fat percentage (left) 0.4 1.5 3.8 0.1 -2.0 -0.8 1.2 -0.9 1.4 1.2 1.4
Arm fat-free mass (left) 0.7 3.6 7.1 -2.2 0.7 -1.9 2.2 0.3 2.7 1.4 2.4
Number of operations (self-reported) 0.2 0.3 1.3 1.1 -0.5 -0.6 -0.3 0.2 -0.3 -0.4 -0.5
Average weekly beer plus cider intake 0.1 0.1 0.3 0.5 -0.3 -0.0 -0.1 -0.1 0.4 -0.4 -0.4
Irritability 0.6 1.0 2.5 -0.1 1.2 0.3 -1.5 0.2 -1.6 -0.1 -1.3
Risk taking 0.5 0.7 1.9 0.4 1.4 -0.4 0.2 0.9 1.0 -1.0 0.6
Ever had prostate specific antigen (PSA) test 0.4 0.4 0.8 0.8 0.6 -0.9 0.6 0.5 0.9 -0.2 0.5
Fractured/broken bones in last 5 years 0.5 0.6 1.2 -0.9 0.5 0.4 0.5 1.0 1.0 -0.4 1.1
Age started oral contraceptive pill 0.9 1.2 3.8 0.8 0.6 1.4 -1.3 2.0 -0.1 -0.6 -0.7
Diastolic blood pressure, automated reading 1.1 3.3 9.9 -0.4 -2.2 -1.9 1.3 -1.5 1.4 3.1 1.5
Ever depressed for a whole week 1.0 1.2 3.2 -0.1 0.9 -1.0 1.0 1.2 1.8 0.1 1.6
Unable to work because of sickness or disability 0.7 0.8 2.5 -0.2 0.3 1.4 -0.3 1.4 -0.6 -1.6 -0.1
Commuting to job workplace: Cycle 0.2 0.2 0.9 -0.4 0.2 -1.0 0.5 -0.1 -0.2 -0.5 -0.2
Myopia 0.1 0.2 0.5 -0.7 -0.1 -0.7 -0.0 0.5 -0.1 0.2 -0.1
Vascular/heart problems diagnosed by doctor 1.4 4.0 8.0 2.8 1.7 1.8 -1.2 1.1 -1.8 -2.8 -1.9
Cholesterol lowering medication 0.8 1.2 3.5 1.7 0.8 1.1 -0.9 1.9 0.8 -0.5 0.4
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 1.1 1.0 -0.1 0.5 0.1 -1.0 -0.2 0.1 -0.2
Pain experienced in last month 0.1 0.2 1.3 -0.1 0.3 1.1 -0.5 0.0 0.2 -0.2 -0.1
Supplements: Calcium 2.0 2.2 5.6 0.7 0.1 1.6 -2.1 0.6 -1.8 -1.2 -2.4
Basal cell carcinoma (self-reported) 0.5 0.6 3.7 1.9 0.8 0.1 -0.4 0.6 0.1 -0.2 0.1
Heart attack/myocardial infarction (self-reported) 0.5 0.7 2.0 1.4 0.4 1.3 -0.9 0.4 0.1 0.6 -0.3
Deep venous thrombosis (DVT) (self-reported) 1.6 2.1 4.5 0.0 -1.0 -1.0 2.0 -0.9 2.1 1.4 1.8
Heart disease (siblings) 2.5 3.1 6.1 -0.8 -1.4 -1.1 2.0 -0.6 2.4 2.2 2.5
Alcohol drinker status: Previous 0.3 0.4 0.7 -0.4 -0.6 -0.1 -0.7 -0.6 -0.6 0.9 -0.7
Pack years of smoking 2.3 3.4 11.3 1.3 -0.3 3.4 -1.7 1.9 -1.5 -1.7 -1.5
Impedance of whole body 0.7 3.6 11.8 -1.2 -3.3 -0.2 0.2 -3.4 -1.1 1.5 -1.0
Leg fat mass (left) 0.2 0.9 1.8 0.0 -0.9 -1.0 1.1 -0.6 1.3 0.7 1.2
Arm predicted mass (left) 0.7 3.6 7.0 -2.2 0.8 -1.9 2.4 0.2 2.6 1.2 2.4