Hub : Genes

IL1A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Lung Adenocarcinoma	0.0278	0.0144	0.0010	0.042	0.034	0.043	NA	0.042	9.2e-06	7.4e-05	7.7e-06	NA	0.00001
2	TCGA	Soft Tissue Sarcoma	0.0750	0.0430	0.0079	0.010	0.030	0.008	NA	0.017	7.4e-02	6.3e-03	9.7e-02	NA	0.03100
3	TCGA	Skin Cutaneous Melanoma	0.1480	0.0810	0.0034	0.134	0.118	0.121	NA	0.139	1.9e-04	4.7e-04	4.0e-04	NA	0.00015

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.4	0.7	0.8	-0.3	-0.7
Bipolar Disorder or Schizophrenia	0.0	0.0	0.0	-0.2	0.1	0.1
Depressed Affect (Nagel 2018)	1.3	2.6	4.1	-1.4	-2.0	1.4
Depression (Nagel 2018)	0.1	0.1	0.2	-0.1	0.5	-0.1
Intelligence (Savage-Jansen 2018)	1.1	3.4	4.0	1.7	2.0	-1.9
Neuroticism (Nagel 2018)	1.5	3.6	4.0	-2.0	-1.8	1.8
Schizophrenia (2018)	0.2	0.5	0.8	-0.9	0.4	0.7
Schizophrenia vs Biploar Disorder	1.0	1.3	1.8	-1.4	-0.7	1.3
Worry (Nagel 2018)	0.8	1.7	3.0	-1.7	-0.7	1.2
Alzheimer’s Disease (in mother)	0.2	0.3	0.3	0.5	0.5	-0.5
Alzheimer’s Disease (in father)	0.5	0.5	0.8	0.9	0.4	-0.8
Alzheimer’s Disease (including proxy)	0.5	0.7	1.0	1.0	0.6	-0.9
Crohns Disease (2017)	0.3	0.7	1.8	0.4	-1.4	-0.4
Irritable Bowel Disease (IBD)	0.4	1.1	1.6	1.3	0.1	-1.2
Ulcerative Colitis (UC)	1.6	3.1	3.5	1.9	1.7	-1.8
Major Depression (MDD)	0.1	0.1	0.2	-0.3	-0.4	0.3
Reaction Time	0.6	1.2	1.9	-1.4	-0.5	1.2
Verbal and Numeric Reasoning (VNR)	1.5	3.7	4.8	1.7	2.2	-1.9
Breast Cancer	0.6	1.4	4.2	-0.2	2.0	0.3
Ovarian Cancer	1.6	2.1	3.1	1.8	0.1	-1.8
Prostate Cancer	0.1	0.2	0.5	0.0	-0.7	-0.2
Age at First Birth	0.5	0.7	2.1	-0.3	1.4	0.1
Bipolar Disorder (2011)	0.2	0.2	0.2	0.4	0.4	-0.5
Body Mass Index (BMI) (2010)	0.4	0.6	1.0	0.7	-1.0	-0.5
Coronary Artery Disease (CAD)	1.5	1.7	2.9	-1.7	-0.2	1.5
Crohns Disease (2012)	1.2	1.9	3.6	1.1	-1.9	-1.0
Mean Putamen Volume	0.7	0.8	1.3	-1.1	0.6	1.0
Fasting Glucose	0.8	1.0	1.6	-0.6	-1.3	0.9
HbA1C	1.0	1.1	1.5	0.9	1.2	-1.1
HDL Cholesterol	1.0	1.7	2.6	-1.5	-0.4	1.6
LDL Cholesterol	0.2	0.2	0.6	-0.1	-0.8	0.3
Lupus	0.0	0.0	0.0	0.0	-0.2	-0.1
Neuroticism (2016)	0.4	0.6	1.1	-0.6	-0.7	1.1
Primary Biliary Cirrhosis	0.8	1.1	1.4	-1.2	-1.0	1.0
Rheumatoid Arthritis	0.2	0.3	0.4	-0.6	0.5	0.4
Schizophrenia (2014)	0.3	0.7	0.8	-0.9	-0.8	0.8
Triglycerides	0.6	0.9	2.2	0.7	-1.5	-0.4
Type 2 Diabetes (T2D) (2012)	1.8	2.1	2.8	1.7	1.1	-1.5
Ulcerative Colitis	0.1	0.1	0.2	-0.4	-0.0	0.3
Blood Eosinophil Count	0.0	0.1	0.1	-0.3	-0.3	-0.1
Blood Platelet Count	0.9	10.4	23.3	2.0	4.8	-2.0
Blood Red Count	0.1	1.4	2.2	-1.2	-0.8	1.5
Blood White Count	2.2	16.3	48.4	0.3	7.0	-0.5
Heel T-Score	0.0	0.3	0.9	-0.2	-1.0	0.1
BMI	1.5	8.9	10.8	-2.6	-3.3	3.0
Height	0.1	1.8	4.9	0.6	-2.2	-0.2
Waist Hip Ratio (WHR)	0.2	0.9	1.1	-1.0	0.7	1.1
Systolic Blood Pressure	0.3	1.7	3.2	-1.4	-0.1	1.8
Smoking Status	3.6	8.7	10.0	-2.8	-3.2	2.8
Allergy or Eczema	1.0	2.7	4.1	1.4	2.0	-1.4
Cardiovascular Disease	2.6	8.6	13.6	-3.3	-1.2	3.7
Hypothyroidism (self reported)	0.2	0.4	0.6	-0.5	0.6	0.7
Respiratory disease	1.7	3.8	5.1	2.2	1.2	-2.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	0.3	0.6	-0.3
Lung FEV1/FVC ratio	0.1	0.5	0.9	-0.8	-0.1	1.0
Lung FVC	0.0	0.2	0.7	-0.1	-0.8	-0.2
Neuroticism	1.2	2.8	3.5	-1.9	-1.7	1.5
Chronotype (morning person)	1.6	3.6	5.5	1.7	2.4	-1.6
Hair Pigment	0.0	0.7	0.8	0.9	0.9	-0.7
Tanning	0.1	0.8	1.1	-1.0	0.6	0.9
Hand grip strength (left)	0.0	0.0	0.1	-0.2	-0.0	0.3
Number of treatments/medications taken	2.1	3.8	5.3	-2.3	-1.0	2.2
Average weekly spirits intake	0.9	1.2	1.7	-1.3	-0.1	1.3
Sensitivity / hurt feelings	0.6	1.0	1.6	-1.1	-0.7	1.2
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	0.2	0.0	-0.1
Hearing difficulty/problems: Yes	0.5	0.8	1.6	-0.8	0.1	1.3
Relative age of first facial hair	3.1	6.3	9.4	3.1	1.4	-2.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	-0.8	0.1	0.8
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.1	0.9	-0.8	-1.1
Ever had hysterectomy (womb removed)	0.0	0.0	0.0	-0.1	0.2	0.0
Systolic blood pressure, automated reading	0.1	0.3	0.6	0.7	-0.4	-0.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	0.9	-0.9	0.2	0.9
Angina	0.2	0.3	0.6	-0.6	0.2	0.7
Medication for hormone replacement therapy	0.0	0.0	0.0	0.1	0.1	-0.0
Vitamin and mineral supplements	1.1	1.5	3.1	-0.5	-1.8	1.1
Supplements: Zinc	0.4	0.4	0.7	-0.6	-0.8	0.5
Medication: Co-codamol	1.1	1.2	2.1	-1.2	-0.1	1.5
Medication: Metformin	0.0	0.1	0.1	0.1	0.3	-0.2
Diabetes (father)	0.8	1.0	1.6	0.7	-1.3	-0.9
Diabetes (mother)	0.7	0.8	1.5	0.9	-0.3	-1.2
Severe depression (siblings)	0.0	0.0	0.0	0.2	-0.2	-0.1
Pack years adult smoking proportion	0.1	0.2	0.3	-0.3	-0.1	0.6
Impedance of leg (right)	0.3	1.2	1.8	1.2	0.7	-1.3
Leg fat-free mass (left)	0.8	4.2	5.1	-1.7	-2.1	2.3
Trunk fat percentage	1.4	5.6	8.0	-2.7	-1.1	2.8
Hand grip strength (right)	0.1	0.2	0.2	0.5	-0.2	-0.5
Townsend deprivation index at recruitment	5.5	7.8	13.2	-2.1	-3.6	2.3
Current tobacco smoking	0.6	1.0	1.3	-1.0	-0.9	1.1
Average weekly fortified wine intake	0.1	0.2	0.2	0.5	-0.5	-0.0
Maternal smoking around birth	0.8	1.2	1.9	-1.3	0.1	1.4
Fed-up feelings	1.9	3.4	5.7	-1.6	-2.4	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.0	1.0	0.3	-0.9
Relative age voice broke	1.0	1.5	2.4	1.6	0.1	-1.5
Taking other prescription medications	0.7	1.1	1.4	-1.2	-0.7	1.2
Age when periods started (menarche)	0.3	0.6	0.8	-0.8	0.9	0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.6	-0.4	-0.8	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.2	-0.4	-0.4	0.4
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	-0.0	-0.1	0.3
Qualifications: CSEs or equivalent	0.6	0.8	1.7	0.5	1.3	-0.6
Serious illness, injury or assault to yourself	0.4	0.5	1.3	-0.3	-1.1	0.4
High blood pressure	5.6	15.7	23.1	-4.6	-1.8	4.8
Hayfever, allergic rhinitis or eczema	1.3	2.9	6.0	1.1	2.4	-1.1
Multivitamins +/- minerals	0.8	1.0	1.3	0.8	1.1	-1.0
Stomach or abdominal pain in last month	1.5	1.9	3.2	1.8	0.6	-1.4
Supplements: Glucosamine	0.6	0.8	2.2	0.1	-1.5	-0.3
Diverticular disease/diverticulitis (self-reported)	2.6	3.0	6.0	-1.1	-2.4	1.4
Medication: Atenolol	3.3	4.2	6.3	-2.5	0.4	2.5
Medication: Levothyroxine sodium	0.7	1.2	1.5	-1.2	0.9	1.1
Sitting height	0.0	0.2	0.4	0.6	-0.3	-0.1
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	0.6	-0.0	-0.5
High blood pressure (mother)	0.1	0.1	0.2	0.0	-0.5	-0.2
Body mass index (BMI)	1.1	4.5	5.9	-2.1	-1.8	2.4
Impedance of leg (left)	0.5	2.3	2.7	1.3	1.6	-1.5
Leg predicted mass (left)	0.8	4.1	5.0	-1.6	-2.2	2.2
Trunk fat mass	1.4	6.2	8.5	-2.6	-1.8	2.9
Waist circumference	1.8	6.5	8.5	-2.7	-2.0	2.9
Number of incorrect matches in round	2.8	4.6	6.2	-2.5	-1.8	2.1
Past tobacco smoking	4.0	7.4	11.0	2.5	3.3	-2.3
Alcohol usually taken with meals	0.0	0.1	0.1	-0.3	0.3	0.0
Nervous feelings	0.2	0.5	0.8	-0.7	0.9	0.2
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.4	3.1	1.5	1.8	-1.4
Hearing difficulty/problems with background noise	0.4	0.7	0.9	-0.6	-0.9	0.9
Hair/balding pattern: Pattern 2	0.1	0.2	0.3	0.4	0.6	0.1
Had menopause	0.5	0.6	1.9	0.0	-1.4	-0.1
Had other major operations	0.2	0.3	0.7	-0.0	-0.8	0.4
Forced vital capacity (FVC)	0.3	1.1	2.8	-0.4	-1.7	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.2	-0.3	-0.3	0.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.8	-0.7	-0.1	0.9
Qualifications: None of the above	0.5	1.1	2.7	-0.6	-1.6	0.7
Financial difficulties in last 2 years	0.5	0.6	1.2	-0.4	-1.1	0.7
Mouth/teeth dental problems	0.9	1.4	1.6	1.2	-1.3	-1.0
Heart attack	3.6	4.6	5.8	-2.1	-1.8	2.4
Allergy	0.8	1.9	2.7	-1.2	-1.6	1.2
Pain all over the body in last month	1.7	1.8	2.3	-1.5	-1.0	1.5
Diabetes (self-reported)	0.4	0.6	1.8	-0.2	1.4	0.0
Hayfever/allergic rhinitis (self-reported)	3.9	5.1	7.7	1.9	2.8	-2.0
Medication: Ramipril	5.5	7.0	10.4	-3.1	-1.1	3.2
Medication: Simvastatin	0.4	0.5	0.8	-0.8	-0.3	0.9
Fluid intelligence score	1.3	2.8	3.3	1.7	1.5	-1.8
Illnesses of siblings	1.5	2.1	3.2	1.3	1.2	-1.8
Neuroticism score	0.4	0.7	1.9	-0.5	-1.4	0.3
Weight	1.1	5.4	6.5	-2.0	-2.4	2.5
Impedance of arm (right)	0.2	0.9	2.7	-0.1	1.6	-0.4
Arm fat percentage (right)	1.2	4.9	6.9	-2.5	-1.2	2.6
Trunk fat-free mass	0.5	3.1	7.4	-0.4	-2.7	1.3
Hip circumference	0.5	2.2	2.5	-1.2	-1.6	1.6
Time employed in main current job	1.1	1.3	2.1	1.4	-0.2	-1.3
Alcohol intake versus 10 years previously	0.5	0.7	1.0	-1.0	-0.7	0.9
Father’s age at death	1.1	1.5	2.9	0.8	1.7	-0.9
Worrier / anxious feelings	0.7	1.4	2.1	-1.4	0.0	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	-0.3	-0.2	0.5
Falls in the last year	1.9	2.6	3.9	-1.9	0.7	2.0
Hair/balding pattern: Pattern 3	1.5	2.2	4.2	-2.0	0.4	1.5
Number of live births	1.9	2.7	4.0	2.0	0.1	-2.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.2	-0.7	-1.1	0.8
Pulse rate	0.2	0.3	0.6	-0.8	0.3	0.6
Happiness	0.6	0.7	1.1	-1.0	-0.1	1.1
Noisy workplace	0.6	0.8	1.5	-0.5	-1.2	0.8
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	0.5	-0.1	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.4	0.6	0.1	-0.7
Mouth/teeth dental problems: Dentures	0.6	1.0	1.6	-1.3	0.5	1.0
Asthma	0.4	0.8	1.3	1.1	-0.1	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.3	-0.6	0.5	0.4
Medication: Cholesterol lowering	2.3	3.6	3.9	-1.9	-2.0	1.8
Depression (self-reported)	0.0	0.0	0.1	0.2	-0.0	-0.3
Medication: Lansoprazole	0.1	0.1	0.1	-0.4	0.4	0.4
Prospective memory result	2.9	3.6	6.9	-1.4	-2.6	1.4
Lung cancer (father)	0.0	0.0	0.1	-0.2	0.1	0.3
Illnesses of mother	0.6	0.8	1.7	0.6	1.3	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	2.8	-0.4	-1.7	0.7
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	0.1	0.3	-0.1
Impedance of arm (left)	0.4	1.7	5.0	-0.3	2.2	-0.3
Arm fat mass (right)	1.2	4.9	6.5	-2.2	-1.9	2.5
Trunk predicted mass	0.5	2.9	7.2	-0.3	-2.7	1.2
Standing height	0.1	0.9	2.4	0.4	-1.6	0.2
Length of working week for main job	1.3	1.5	2.3	1.1	1.5	-1.0
Exposure to tobacco smoke at home	2.6	2.9	4.8	-2.0	-0.3	2.2
Breastfed as a baby	1.3	1.6	2.4	1.5	-0.7	-1.4
Tense / ‘highly strung’	0.0	0.1	0.2	0.1	0.5	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.4	-0.7	0.3
Hair/balding pattern: Pattern 4	0.9	2.2	2.8	1.5	1.2	-1.7
Birth weight of first child	0.4	0.8	1.1	0.9	0.6	-1.0
Peak expiratory flow (PEF)	0.3	0.7	1.1	-1.0	-0.2	1.0
Pulse wave reflection index	0.2	0.2	0.4	0.3	-0.6	-0.3
Ever highly irritable/argumentative for 2 days	1.7	2.0	2.6	-1.4	-1.6	1.3
Loud music exposure frequency	2.9	3.1	3.8	1.9	1.4	-1.9
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	2.8	1.7	0.9	-1.6
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.6	-0.2	1.2	0.2
Blood clot in the leg (DVT)	0.2	0.3	0.5	0.7	-0.2	-0.6
Medication: Paracetamol	0.6	1.0	1.7	-1.1	0.4	1.3
Headache pain in last month	0.1	0.2	0.4	-0.2	0.2	0.6
Medication for cholesterol, blood pressure or diabetes	4.5	7.5	9.4	3.1	2.0	-3.0
Glaucoma (self-reported)	0.8	0.9	1.6	-0.7	-1.2	0.8
Gout (self-reported)	0.6	0.8	1.3	-1.1	-0.5	0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.5	-0.6	0.4	0.7
Medication: Amlodipine	0.6	0.9	1.0	-0.8	-1.0	1.0
Medication: Ventolin 100micrograms inhaler	1.2	1.5	2.3	1.3	-0.6	-1.5
Birth weight	2.0	4.3	4.7	2.2	-2.1	-1.9
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.4	0.2	-0.3
High blood pressure (siblings)	1.9	2.7	3.3	-1.6	-1.5	1.8
Forced vital capacity (FVC), Best measure	0.5	1.8	5.3	-0.1	-2.3	0.3
Body fat percentage	1.4	5.5	7.8	-2.7	-1.2	2.8
Leg fat percentage (right)	1.8	6.4	8.1	-2.7	-1.9	2.8
Arm fat-free mass (right)	0.4	2.3	5.0	-0.5	-2.2	1.3
Exposure to tobacco smoke outside home	1.2	1.6	2.2	-0.9	-1.4	1.5
Comparative body size at age 10	0.8	2.1	6.0	-0.4	-2.4	0.3
Number of full brothers	1.2	1.5	2.2	1.5	-0.6	-1.4
Worry too long after embarrassment	0.5	0.9	1.1	-1.0	-0.8	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.0	-0.7	-1.0	0.9
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	0.2	0.9	-0.3
Number of children fathered	0.8	0.9	2.3	-0.4	-1.5	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	-0.3	0.2	0.3
Age at first live birth	1.9	3.3	4.8	2.1	0.9	-2.2
Pulse wave peak to peak time	0.1	0.1	0.3	-0.1	-0.5	0.1
Health satisfaction	1.2	1.6	2.4	-1.6	-0.2	1.5
Shortness of breath walking on level ground	0.4	0.5	0.8	-0.7	0.9	0.5
Qualifications: College or University degree	0.0	0.1	0.2	0.5	0.2	-0.4
Eye problems/disorders: None of the above	2.6	3.0	4.6	2.1	0.4	-2.1
Mouth/teeth dental problems: Loose teeth	0.6	0.7	0.8	0.9	0.8	-0.9
Emphysema/chronic bronchitis	0.0	0.0	0.0	-0.2	0.1	0.2
Medication for pain relief, constipation, heartburn	3.1	5.4	7.5	2.7	1.1	-2.7
Neck or shoulder pain in last month	0.7	1.0	2.6	-0.3	-1.6	0.7
Medication: Blood pressure	6.9	12.1	15.3	-3.6	-2.8	3.9
Angina (self-reported)	0.5	0.6	1.1	-0.9	0.0	1.0
Migraine (self-reported)	0.4	0.5	0.6	-0.8	-0.7	0.6
Medication: Ibuprofen	1.2	1.5	2.0	-1.4	-0.7	1.4
Medication: Allopurinol	0.9	1.2	2.0	-1.4	0.0	1.3
Medication: Omeprazole	2.4	2.9	4.8	-1.3	-2.2	1.4
Medication: Seretide 50 evohaler	2.1	2.4	3.3	1.8	0.7	-1.8
Mean time to correctly identify matches	2.1	4.0	5.9	-2.4	-1.0	2.2
Heart disease (mother)	0.3	0.4	0.5	-0.5	-0.7	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	3.3	-1.2	-1.8	1.4
Whole body fat mass	1.3	5.3	7.3	-2.4	-1.7	2.7
Leg fat mass (right)	1.6	6.4	8.0	-2.5	-2.2	2.8
Arm predicted mass (right)	0.5	2.7	6.8	-0.3	-2.6	1.1
Pulse rate, automated reading	0.0	0.1	0.1	-0.1	-0.4	0.1
Alcohol intake frequency.	0.3	0.7	1.2	-0.9	0.3	1.1
Comparative height size at age 10	0.7	4.1	8.5	-1.2	-2.9	1.5
Number of full sisters	0.7	0.9	1.8	1.3	0.1	-0.9
Suffer from ‘nerves’	0.6	1.0	2.5	-0.6	-1.6	0.1
Overall health rating	1.6	3.5	4.6	-2.1	-1.2	2.1
Chest pain or discomfort	1.3	1.9	2.5	1.3	1.6	-1.1
Had major operations	4.1	4.8	7.5	-1.8	-2.7	1.9
Age at last live birth	0.7	1.0	1.5	1.2	0.3	-1.2
Family relationship satisfaction	1.4	1.7	4.4	0.4	2.1	-0.7
Leg pain on walking	0.2	0.3	0.6	-0.5	-0.3	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.6	0.7	1.3	-0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.7	-0.3	-0.8	0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.4	0.0	0.6	-0.0
Medication: Aspirin	3.2	4.2	5.4	-2.3	-1.6	2.2
Supplements: Vitamin C	1.1	1.3	2.0	-1.4	1.0	0.9
Knee pain experienced in last month	0.9	1.5	4.2	0.5	-2.0	-0.1
Hypertension (Self-reported)	4.7	13.0	19.0	-4.2	-1.6	4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	2.9	-1.1	-1.7	1.3
Illnesses of father: Heart disease	3.3	4.6	6.1	-2.3	-1.6	2.5
Illnesses of siblings: Diabetes	0.0	0.0	0.1	-0.0	0.1	0.3
Smoking status: Previous	4.2	6.3	8.4	-2.4	-2.9	2.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	0.2	0.3	0.3
Whole body fat-free mass	0.6	3.2	6.5	-0.8	-2.5	1.6
Leg fat-free mass (right)	0.5	2.9	3.8	-1.4	-1.7	2.0
Arm fat percentage (left)	1.1	4.4	6.5	-2.5	-0.8	2.5
Average weekly red wine intake	1.5	2.3	2.9	-1.5	-1.7	1.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.4	0.6	-0.6	-0.4
Mood swings	0.8	1.5	4.0	-0.5	-2.0	0.6
Loneliness, isolation	0.1	0.1	0.4	-0.0	-0.6	0.1
Long-standing illness, disability or infirmity	0.1	0.2	0.2	-0.3	0.5	0.5
Ever had bowel cancer screening	0.6	0.7	1.6	0.6	-1.3	-0.3
Diabetes diagnosed by doctor	0.3	0.6	1.6	-0.1	1.3	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.3	-0.1	-1.2	0.1
Friendships satisfaction	0.8	1.0	2.3	0.6	1.5	-0.6
Qualifications: nursing, teaching	0.3	0.5	0.6	0.5	0.8	-0.7
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.2	0.1	-0.1
Eye problems/disorders: Cataract	0.7	0.8	1.3	-1.2	-0.5	0.8
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	-0.2	0.6	0.2
Medication for cholesterol	0.4	0.6	0.6	0.7	-0.8	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	3.6	-1.8	-0.3	1.9
Back pain experienced in last month	0.7	1.0	1.3	1.0	0.9	-1.1
Mineral and other dietary supplements	0.9	1.3	2.2	1.0	1.5	-0.8
Breast cancer (self-reported)	1.0	1.1	3.2	0.3	-1.8	-0.3
Asthma (self-reported)	0.4	0.9	1.3	1.1	-0.2	-1.1
Osteoporosis (self-reported)	0.6	0.7	1.4	0.7	1.2	-0.5
Osteoarthritis (self-reported)	0.3	0.4	0.7	-0.7	-0.0	0.9
Medication: Aspirin	2.5	3.3	5.1	-2.3	-1.0	2.0
Medication: Gliclazide	0.2	0.2	0.3	-0.6	0.2	0.5
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.0	0.3	0.0
Smoking status: Current	0.9	1.5	1.8	-1.1	-1.2	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.9	-0.6	-1.7	0.7
Whole body water mass	0.6	3.2	6.2	-0.9	-2.5	1.6
Leg predicted mass (right)	0.5	2.8	3.7	-1.4	-1.7	1.9
Arm fat mass (left)	1.1	4.6	6.6	-2.2	-1.4	2.6
Number of self-reported non-cancer illnesses	1.1	1.9	2.9	-1.6	-0.4	1.7
Average weekly champagne plus white wine intake	0.1	0.2	0.5	-0.2	-0.7	0.2
Miserableness	0.6	1.1	2.8	0.6	-1.7	-0.3
Guilty feelings	0.6	0.8	2.1	-0.5	-1.5	0.4
Wears glasses or contact lenses	0.3	0.3	0.7	-0.4	-0.8	0.3
Ever taken oral contraceptive pill	3.1	3.4	4.5	2.1	1.2	-2.1
Hearing aid user	0.5	0.6	0.8	-0.9	0.5	0.8
Mother’s age at death	0.5	0.6	0.9	0.9	-0.4	-1.0
Financial situation satisfaction	0.5	0.6	0.9	-0.9	-0.3	0.9
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.2	-1.0	-0.8	1.1
Commuting to job workplace: Public transport	1.0	1.1	1.7	-1.3	-0.3	1.3
Eye problems/disorders: Glaucoma	1.2	1.4	2.3	-0.9	-1.5	1.1
Medication: Blood pressure	1.4	2.7	4.0	-2.0	0.4	2.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.6	-0.3	-0.8	0.6
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.8	-0.6	-1.3	0.5
High cholesterol (Self-reported)	1.3	2.3	2.5	-1.5	-1.5	1.6
Medication: Bendroflumethiazide	4.5	6.8	7.2	-2.5	-2.6	2.7
Medication: Paracetamol	1.1	1.7	2.4	-1.4	0.7	1.6
Medication: Lisinopril	1.7	2.3	2.6	-1.4	-1.6	1.5
Medication: Atorvastatin	0.8	1.0	1.8	-1.0	-0.5	1.3
Illnesses of father: High blood pressure	0.6	0.7	1.6	0.5	1.3	-0.6
Alcohol drinker status: Never	0.1	0.2	0.5	0.1	-0.7	0.0
Ever smoked	4.2	7.3	7.7	-2.8	-2.7	2.7
Basal metabolic rate	0.7	4.0	6.2	-1.3	-2.5	2.0
Leg fat percentage (left)	1.6	5.7	7.5	-2.6	-1.7	2.7
Arm fat-free mass (left)	0.8	3.9	7.8	-0.9	-2.8	1.7
Number of operations (self-reported)	3.9	5.8	6.7	-2.2	-2.6	2.4
Average weekly beer plus cider intake	0.2	0.3	0.4	-0.5	0.6	0.6
Irritability	0.5	0.9	0.9	-1.0	-0.9	0.9
Risk taking	0.2	0.3	0.8	0.2	-0.9	0.2
Ever had prostate specific antigen (PSA) test	2.8	3.2	4.1	-1.4	-2.0	1.9
Fractured/broken bones in last 5 years	0.2	0.2	0.3	-0.4	-0.4	0.5
Age started oral contraceptive pill	0.4	0.5	1.5	-0.4	-1.2	-0.1
Diastolic blood pressure, automated reading	0.1	0.4	1.1	0.2	-1.1	0.3
Ever depressed for a whole week	0.3	0.4	0.6	0.5	-0.8	-0.5
Unable to work because of sickness or disability	0.7	0.9	1.3	-0.7	-1.1	1.0
Commuting to job workplace: Cycle	1.5	1.8	2.6	1.6	0.5	-1.6
Myopia	0.7	1.0	1.5	1.0	1.2	-0.7
Vascular/heart problems diagnosed by doctor	4.8	13.0	19.4	4.1	1.5	-4.4
Cholesterol lowering medication	0.0	0.1	0.2	-0.1	0.0	0.4
Medication: Omeprazole (e.g. Zanprol)	3.2	3.9	6.3	-1.5	-2.5	1.8
Pain experienced in last month	0.3	0.4	1.0	0.4	1.0	-0.4
Supplements: Calcium	0.6	0.7	0.9	0.6	0.8	-0.9
Basal cell carcinoma (self-reported)	0.5	0.6	1.3	-0.7	-1.1	0.3
Heart attack/myocardial infarction (self-reported)	3.1	4.1	5.7	-2.1	-1.5	2.4
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.8	0.9	-0.2	-0.9
Heart disease (siblings)	0.4	0.5	0.8	-0.8	-0.1	0.9
Alcohol drinker status: Previous	4.2	4.8	7.0	-2.6	-0.8	2.6
Pack years of smoking	0.2	0.3	0.5	-0.6	-0.4	0.7
Impedance of whole body	0.4	2.1	4.7	0.6	2.2	-1.1
Leg fat mass (left)	1.5	5.8	7.6	-2.5	-1.9	2.8
Arm predicted mass (left)	0.7	3.6	8.5	-0.6	-2.9	1.4