TWAS hub - IL1RN

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0780	0.0320	2.1e-03	0.031	NA	0.031	NA	0.049	1.3e-03	NA	1.3e-03	NA	7.6e-05
2	GTEx	Brain Cerebellar Hemisphere	0.7060	0.1110	2.5e-03	0.013	NA	0.172	NA	0.082	1.4e-01	NA	3.5e-05	NA	3.9e-03
3	METSIM	Adipose	0.0336	0.0155	5.1e-03	0.000	0.011	-0.001	0.012	0.002	3.7e-01	7.0e-03	4.6e-01	0.006	1.7e-01
4	NTR	Blood	0.0137	0.0067	1.1e-02	-0.001	0.002	-0.001	0.002	-0.001	6.6e-01	5.7e-02	7.2e-01	0.054	8.9e-01
5	TCGA	Breast Invasive Carcinoma	0.0537	0.0171	4.3e-12	0.069	0.067	0.070	NA	0.072	5.4e-14	1.6e-13	4.3e-14	NA	1.3e-14
6	TCGA	Prostate Adenocarcinoma	0.0584	0.0227	6.5e-06	0.079	0.062	0.068	NA	0.082	1.3e-08	4.7e-07	1.2e-07	NA	6.7e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5	6
Blood White Count	10.8	79.8	144.0	-10.2	-11.1	-5.6	-12.0	-8.7
Lung cancer (father)	4.1	4.8	11.0	2.5	0.9	0.4	3.3	3.3
Birth weight	3.1	6.8	12.5	2.4	-1.9	2.6	3.5	3.5
Tinnitus: Yes, now most or all of the time	3.1	3.6	10.0	2.7	3.2	-2.0	0.2	-0.4
Gout (self-reported)	2.8	3.8	11.8	-3.4	-1.8	-0.7	-2.3	-1.5
Medication: Ventolin 100micrograms inhaler	2.8	3.7	12.5	1.3	-3.5	0.7	1.7	2.1
Severe depression (siblings)	2.6	2.9	7.0	2.0	2.6	-1.7	1.3	1.2
Blood Platelet Count	2.5	28.6	63.7	-5.4	-5.6	-2.5	-8.0	-6.4
Allergy or Eczema	2.5	6.5	20.0	-0.5	-4.5	3.2	2.2	1.9
Allergy	2.5	5.7	25.7	1.9	5.1	-2.3	-0.0	-0.1
Supplements: Calcium	2.5	2.8	10.4	-1.2	-3.2	1.8	-1.0	-0.6
Medication: Aspirin	2.3	3.0	7.6	1.0	0.2	1.3	2.8	2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.8	15.2	2.6	3.9	-0.3	2.2	1.5
Hayfever, allergic rhinitis or eczema	2.2	4.7	18.8	-0.6	-4.3	2.3	1.4	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	5.7	1.9	0.4	-1.1	2.2	2.4
Rheumatoid Arthritis	2.1	2.9	7.2	-2.7	-2.4	0.1	-1.9	-0.7
Age at last live birth	2.1	3.1	6.9	-1.6	1.1	1.5	-2.4	-2.6
Medication: Aspirin	2.1	2.7	6.7	0.8	0.8	1.6	2.6	2.5
Smoking status: Previous	2.1	3.2	8.0	-2.8	-1.3	2.3	-1.7	-1.1
Number of operations (self-reported)	2.1	3.1	7.5	1.9	1.1	0.0	2.7	2.5
Past tobacco smoking	2.0	3.6	8.8	3.0	1.1	-2.8	1.7	1.0
Medication: Bendroflumethiazide	2.0	3.1	8.2	1.6	0.8	0.9	2.9	2.5
Cholesterol lowering medication	2.0	3.0	6.7	1.9	0.5	1.3	2.6	2.4
Leg pain on walking	1.9	2.4	6.7	1.9	2.6	-0.2	1.7	1.1
Commuting to job workplace: Car/motor vehicle	1.8	2.1	4.3	1.3	0.6	-1.6	1.9	2.1
Medication: Lisinopril	1.8	2.4	4.9	-0.3	-1.3	2.1	1.9	2.2
Unable to work because of sickness or disability	1.8	2.4	7.6	1.1	2.8	-1.7	1.2	1.1
Chronic bronchitis/emphysema (father)	1.7	2.0	5.4	0.7	-1.5	0.8	1.7	2.3
Risk taking	1.7	2.5	5.3	2.3	1.2	-1.1	1.9	1.9
Prostate Cancer	1.6	2.3	4.6	-2.1	-2.1	-1.4	-1.4	-1.0
Illnesses of siblings	1.6	2.3	5.3	-1.8	-1.8	2.3	-1.1	-0.9
Medication: Paracetamol	1.6	2.7	5.2	-1.8	-0.6	-2.1	-2.3	-1.8
Osteoporosis (self-reported)	1.6	2.0	4.0	1.0	-0.9	-1.7	2.0	1.8
Medication: Gliclazide	1.6	1.8	4.4	1.4	0.8	0.0	1.9	2.1
Ever had prostate specific antigen (PSA) test	1.6	1.9	3.6	1.2	1.7	-0.1	1.8	1.9
Age when periods started (menarche)	1.5	3.7	11.2	-1.1	0.5	-3.3	-2.1	-2.3
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	4.3	1.5	-0.2	0.3	2.1	2.0
Hayfever/allergic rhinitis (self-reported)	1.5	1.9	11.0	-0.4	-3.3	0.7	-0.0	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	5.2	0.8	1.3	0.5	2.0	2.3
Wheeze or whistling in the chest in last year	1.5	2.7	5.4	-0.2	-2.3	2.3	1.5	1.8
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	3.1	1.5	1.8	-1.5	1.2	1.1
Supplements: Fish oil (including cod liver oil)	1.5	2.0	4.9	-1.0	0.6	1.4	-2.0	-2.2
Medication: Paracetamol	1.5	2.3	4.0	-1.7	-0.9	-1.8	-2.0	-1.7
Alcohol drinker status: Never	1.5	1.9	6.4	2.5	1.1	-0.1	1.6	1.0
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	2.7	1.7	1.3	-0.0	1.6	1.5
Hearing difficulty/problems with background noise	1.4	2.2	5.1	1.0	1.7	2.3	1.6	1.4
Alcohol intake versus 10 years previously	1.4	2.1	5.8	-1.4	-0.1	-0.1	-2.4	-2.3
Falls in the last year	1.4	1.9	3.6	1.5	1.9	-1.9	1.0	1.0
Pulse wave reflection index	1.4	1.7	6.4	-2.5	-1.6	0.8	-0.7	-0.2
High blood pressure (siblings)	1.4	2.0	6.6	1.2	2.6	-1.0	1.4	1.0
Angina (self-reported)	1.4	1.9	6.0	2.5	1.3	-0.1	1.5	1.1
Ever had hysterectomy (womb removed)	1.3	1.4	3.9	2.0	-0.2	-0.6	1.5	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.2	11.1	2.6	3.3	0.7	2.1	1.6
Handedness (chirality/laterality): Left-handed	1.3	1.5	5.1	1.0	2.2	-1.7	-0.0	-0.2
Friendships satisfaction	1.3	1.6	6.7	-1.4	-2.6	1.0	-0.2	-0.1
Wears glasses or contact lenses	1.3	1.5	3.8	0.9	0.7	1.9	1.7	0.9
Heart attack/myocardial infarction (self-reported)	1.3	1.7	8.0	1.0	2.8	-0.0	0.9	0.6
Crohns Disease (2017)	1.2	2.7	14.4	-0.2	-1.2	-3.8	-0.5	0.2
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.8	0.6	-1.9	-0.1	1.1	1.8
Respiratory disease	1.2	2.8	12.6	-1.4	-3.5	1.4	-0.3	-0.2
Qualifications: CSEs or equivalent	1.2	1.6	4.6	-2.1	-1.6	-0.7	-1.2	-0.6
Heart attack	1.2	1.6	7.8	1.0	2.8	-0.0	0.8	0.5
Pain all over the body in last month	1.2	1.3	4.2	0.4	2.1	-1.5	0.8	0.7
Medication: Simvastatin	1.2	1.8	5.0	2.2	0.8	1.6	1.3	0.8
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	13.2	2.7	3.6	0.7	1.6	1.1
Chronic bronchitis/emphysema (mother)	1.2	1.3	2.8	-1.6	0.4	0.3	-1.6	-1.7
Age at first live birth	1.2	2.2	4.1	-1.2	0.2	1.8	-2.0	-2.0
Emphysema/chronic bronchitis	1.2	1.4	3.3	-1.3	-1.8	-0.5	-1.4	-0.9
Medication: Blood pressure	1.2	2.1	4.4	1.1	2.1	0.8	1.8	1.7
Ever smoked	1.2	2.2	7.6	-2.8	-0.3	1.9	-1.2	-0.3
Reaction Time	1.1	2.0	5.8	1.1	-0.9	-0.0	2.1	2.4
Ovarian Cancer	1.1	1.5	2.4	0.9	-1.5	1.5	1.1	1.5
Bipolar Disorder (2011)	1.1	1.1	4.5	0.8	0.4	-2.1	0.5	0.9
LDL Cholesterol	1.1	1.7	4.8	2.0	2.2	-0.4	1.0	0.2
Medication: Co-codamol	1.1	1.2	2.2	1.5	1.3	-0.5	1.2	1.3
Asthma	1.1	2.1	9.3	-1.6	-3.0	0.7	-0.5	-0.1
Breastfed as a baby	1.1	1.4	3.3	-1.8	-0.8	1.3	-1.0	-1.2
Forced vital capacity (FVC), Best measure	1.1	4.0	8.3	2.4	2.9	1.2	2.2	2.0
Medication: Allopurinol	1.1	1.4	4.8	-2.2	-1.1	-0.5	-1.4	-0.7
Asthma (self-reported)	1.1	2.3	9.8	-1.7	-3.1	0.9	-0.4	-0.0
Irritable Bowel Disease (IBD)	1.0	2.5	11.4	-0.4	-1.7	-3.4	-0.6	-0.2
Angina	1.0	1.4	4.7	2.2	1.1	-0.1	1.2	0.9
Had other major operations	1.0	1.3	2.6	1.4	-0.6	-0.1	1.6	1.6
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	3.3	-1.3	0.4	-0.0	-1.8	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.5	-1.1	0.4	0.3	-1.7	-1.9
Exposure to tobacco smoke at home	1.0	1.1	3.0	-1.7	-0.7	-1.3	-1.1	-0.5
Comparative height size at age 10	1.0	5.3	12.0	1.2	1.4	3.5	3.0	2.8
Illnesses of father: Heart disease	1.0	1.4	6.9	0.1	2.6	-1.1	0.4	0.3
Breast cancer (self-reported)	1.0	1.2	4.8	1.4	2.2	-0.0	0.7	0.5
Coronary Artery Disease (CAD)	0.9	1.0	2.7	1.4	1.7	-1.2	0.4	-0.2
Cardiovascular Disease	0.9	2.9	8.3	1.0	1.1	-0.1	2.6	2.9
Hand grip strength (left)	0.9	2.3	4.5	1.4	1.6	-1.2	1.8	2.1
Diabetes (self-reported)	0.9	1.4	3.8	1.9	0.9	-1.2	1.2	1.1
Trunk fat-free mass	0.9	5.1	9.7	1.6	1.7	2.5	3.1	3.1
Trunk predicted mass	0.9	5.0	9.4	1.6	1.6	2.6	3.1	3.0
Hair/balding pattern: Pattern 4	0.9	2.1	4.8	-1.5	-0.2	1.4	-2.0	-2.2
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	3.5	-1.2	-0.6	-1.9	-1.0	-0.7
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.1	-1.2	-2.0	-0.7	-1.3	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.5	-0.9	1.1	0.3	-1.2	-1.6
Pulse wave peak to peak time	0.9	1.1	4.1	2.0	0.3	-0.9	1.0	0.6
Number of full sisters	0.9	1.1	4.0	-0.7	0.8	-2.0	-1.0	-0.6
Supplements: Vitamin C	0.9	1.1	2.9	-0.5	0.7	-0.9	-1.5	-1.7
Eye problems/disorders: Cataract	0.9	1.0	2.3	-0.5	-0.4	-1.0	-1.5	-1.5
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	7.3	0.9	2.7	0.4	0.2	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	3.2	-0.5	1.1	-1.8	-1.1	-0.8
Myopia	0.9	1.3	3.0	-1.4	-0.6	0.3	-1.7	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.5	-1.4	-0.7	-0.0	-1.4	-1.6
Bipolar Disorder or Schizophrenia	0.8	2.0	6.5	1.4	-0.0	-2.5	1.2	1.5
Major Depression (MDD)	0.8	1.0	3.9	-0.2	-0.9	0.2	1.2	2.0
Crohns Disease (2012)	0.8	1.3	3.8	-0.6	-1.8	-2.0	-0.0	0.6
Medication for hormone replacement therapy	0.8	0.8	1.8	-1.4	0.2	-0.5	-1.1	-1.3
Medication: Metformin	0.8	1.1	2.1	1.3	0.9	0.6	1.4	1.3
Diabetes (father)	0.8	1.0	4.7	0.9	-2.2	0.6	-0.2	0.2
Taking other prescription medications	0.8	1.2	2.6	-1.4	1.6	0.1	-1.1	-1.2
Medication: Ramipril	0.8	1.0	4.2	1.1	2.0	0.3	0.7	0.6
Illnesses of mother	0.8	0.9	1.7	-1.0	-0.8	0.9	-1.3	-1.2
Impedance of arm (left)	0.8	3.8	6.2	-1.8	-2.0	-2.3	-2.5	-1.9
High cholesterol (Self-reported)	0.8	1.5	2.5	1.2	1.0	1.6	1.5	1.3
Impedance of whole body	0.8	4.1	7.2	-1.7	-1.9	-2.7	-2.6	-2.1
Bipolar Disorder (2018)	0.7	1.1	2.1	1.4	0.1	-1.4	0.9	1.4
Worry (Nagel 2018)	0.7	1.4	4.5	-1.7	-0.2	2.1	-0.8	-0.3
Body Mass Index (BMI) (2010)	0.7	0.9	2.6	0.3	0.5	1.0	1.2	1.6
Fasting Glucose	0.7	0.9	2.1	0.6	0.9	0.5	1.3	1.4
HDL Cholesterol	0.7	1.2	3.3	0.8	0.2	0.5	1.8	1.7
Neuroticism (2016)	0.7	1.1	3.0	0.4	-1.7	0.3	1.0	1.4
Waist Hip Ratio (WHR)	0.7	3.3	6.1	2.5	2.4	1.2	2.1	1.5
Lung FVC	0.7	3.5	13.5	2.5	3.7	-0.2	1.0	-0.0
Average weekly spirits intake	0.7	0.9	3.6	-0.6	-1.9	-0.9	-0.4	-0.4
Hand grip strength (right)	0.7	2.0	5.9	1.1	-0.1	-1.2	1.8	2.4
Stomach or abdominal pain in last month	0.7	0.8	1.5	0.5	1.0	-0.9	1.2	1.2
Forced vital capacity (FVC)	0.7	2.5	7.2	1.8	2.7	1.1	1.4	1.4
Pulse wave Arterial Stiffness index	0.7	0.8	3.4	-1.9	-0.1	0.9	-0.7	-0.3
Length of working week for main job	0.7	0.8	3.9	0.1	-2.0	-0.2	0.6	0.6
Birth weight of first child	0.7	1.3	4.1	0.5	0.3	0.2	2.0	1.8
Ever highly irritable/argumentative for 2 days	0.7	0.8	3.5	-0.4	1.9	-0.5	-0.7	-0.8
Blood clot in the leg (DVT)	0.7	1.0	1.9	-1.4	-0.8	-0.5	-1.2	-1.3
Number of full brothers	0.7	0.8	4.7	-0.1	-0.5	-2.2	-0.0	-0.2
Mean time to correctly identify matches	0.7	1.4	3.3	1.5	0.2	0.4	1.8	1.7
Had major operations	0.7	0.9	1.9	-0.2	1.4	1.0	1.1	1.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	3.7	-1.9	-0.4	0.4	-0.7	-0.7
Whole body fat-free mass	0.7	4.0	8.2	1.2	1.1	2.4	2.7	2.9
Average weekly red wine intake	0.7	1.0	2.3	1.3	0.0	0.7	1.5	1.2
Mineral and other dietary supplements	0.7	1.0	2.5	0.8	-0.0	-1.6	1.0	1.3
Whole body water mass	0.7	3.9	7.7	1.1	1.3	2.4	2.6	2.8
Mother’s age at death	0.7	0.8	3.3	-0.5	0.5	1.8	-0.6	-0.9
Illnesses of father: High blood pressure	0.7	0.8	2.3	-0.7	0.2	0.9	-1.1	-1.5
Arm fat-free mass (left)	0.7	3.6	7.6	1.2	1.6	1.9	2.6	2.8
Average weekly beer plus cider intake	0.7	1.0	5.1	0.5	0.5	-2.3	0.4	0.6
Fractured/broken bones in last 5 years	0.7	0.9	2.6	-0.4	0.9	-1.6	-0.8	-1.1
Vascular/heart problems diagnosed by doctor	0.7	2.0	5.1	-1.2	-0.2	0.6	-2.2	-2.3
Basal cell carcinoma (self-reported)	0.7	0.8	2.3	-0.3	1.5	-0.7	-1.1	-0.9
Arm predicted mass (left)	0.7	3.6	6.4	1.2	1.6	2.3	2.5	2.5
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.4	1.5	1.6	-0.4	1.2	0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.6	0.1	-0.5	-1.3	1.0	1.2
Vitamin and mineral supplements	0.6	0.8	2.5	0.7	0.4	-0.2	1.2	1.6
Average weekly fortified wine intake	0.6	0.6	3.4	-0.5	-0.5	1.9	0.0	0.1
High blood pressure	0.6	1.7	4.9	0.7	-0.0	-0.6	2.1	2.2
Impedance of leg (left)	0.6	2.9	7.7	-1.1	-0.9	-2.8	-2.1	-1.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.2	-0.3	1.8	-1.1	-0.9	-0.8
Medication: Lansoprazole	0.6	0.6	1.3	1.1	0.3	-0.5	1.1	1.1
Arm fat-free mass (right)	0.6	3.2	6.6	1.1	1.1	2.0	2.5	2.6
Neck or shoulder pain in last month	0.6	0.8	3.2	-1.8	-1.0	-0.2	-0.7	0.0
Migraine (self-reported)	0.6	0.7	1.4	1.1	-1.2	0.2	1.0	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.1	0.4	-0.1	-0.6	1.3	1.5
Arm predicted mass (right)	0.6	3.3	6.1	1.0	1.1	2.5	2.3	2.4
Family relationship satisfaction	0.6	0.8	3.9	-0.6	-2.0	-0.7	-0.1	0.1
Hypertension (Self-reported)	0.6	1.7	5.4	0.3	-0.3	-0.6	2.1	2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.7	1.1	0.0	-1.6	0.1	0.4
Eye problems/disorders: Glaucoma	0.6	0.7	2.5	0.1	1.6	-1.2	0.4	0.1
Medication: Blood pressure	0.6	1.1	2.2	0.9	-1.0	-1.2	1.2	1.5
Basal metabolic rate	0.6	3.3	7.7	0.8	0.9	2.1	2.4	2.8
Age started oral contraceptive pill	0.6	0.7	2.9	0.1	-0.6	1.7	-0.2	-1.1
Heart disease (siblings)	0.6	0.7	2.4	1.5	0.6	-1.1	0.6	0.2
Schizophrenia (2018)	0.5	1.1	4.8	0.7	-0.1	-2.2	0.8	0.8
HbA1C	0.5	0.6	1.7	1.3	-0.9	0.7	0.2	0.7
Lupus	0.5	0.8	2.7	-1.4	-1.6	0.4	-0.1	0.3
Triglycerides	0.5	0.9	2.8	1.2	1.7	-0.0	1.0	0.4
Ulcerative Colitis	0.5	0.7	2.2	-0.1	-1.4	-1.5	-0.3	-0.2
Lung FEV1/FVC ratio	0.5	2.6	11.0	3.3	1.4	-1.2	1.1	0.2
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.0	1.1	-0.1	-0.4	0.9	1.4
Pack years adult smoking proportion	0.5	0.8	2.1	-1.5	-1.0	-1.1	0.0	0.7
Leg fat-free mass (left)	0.5	2.4	6.0	0.5	0.4	1.9	2.0	2.5
Townsend deprivation index at recruitment	0.5	0.7	3.2	0.8	1.8	0.4	0.4	0.4
Maternal smoking around birth	0.5	0.8	2.0	-0.8	-1.4	-1.0	-1.0	-0.0
Fed-up feelings	0.5	0.9	3.2	0.4	1.2	-1.8	0.3	0.6
Leg predicted mass (left)	0.5	2.4	6.2	0.5	0.3	2.0	2.0	2.5
Hair/balding pattern: Pattern 2	0.5	0.6	1.7	0.1	1.3	-1.3	-0.3	-0.4
Fluid intelligence score	0.5	1.0	4.2	-0.2	-2.1	1.3	0.1	0.2
Impedance of arm (right)	0.5	2.5	5.1	-1.1	-1.4	-2.2	-2.0	-1.6
Worrier / anxious feelings	0.5	0.9	2.9	-1.4	-0.2	1.7	-0.8	-0.2
Qualifications: A levels/AS levels or equivalent	0.5	1.0	5.1	2.3	0.7	-0.2	0.6	0.5
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.6	-1.3	-0.1	-1.6	-1.1	-0.6
Number of children fathered	0.5	0.5	1.9	-0.5	-0.4	1.4	0.6	0.6
Medication: Seretide 50 evohaler	0.5	0.6	1.7	-0.2	-0.0	0.5	-1.3	-1.3
Chest pain or discomfort	0.5	0.7	2.5	-0.3	-0.3	0.7	1.0	1.6
Loneliness, isolation	0.5	0.7	1.9	-1.1	-0.6	-1.4	-0.7	-0.3
Number of self-reported non-cancer illnesses	0.5	0.9	2.7	-1.5	-1.6	0.6	-0.5	-0.4
Medication: Atorvastatin	0.5	0.6	2.2	0.6	0.5	-1.5	0.6	0.5
Irritability	0.5	0.9	2.4	0.8	-0.5	0.6	1.2	1.6
Alzheimer’s Disease (in mother)	0.4	0.5	1.1	0.5	-0.2	-1.0	0.9	0.8
Alzheimer’s Disease (in father)	0.4	0.4	0.8	0.3	0.9	0.9	0.7	0.5
Ulcerative Colitis (UC)	0.4	0.8	2.5	-0.3	-1.3	-1.6	-0.5	-0.6
Age at First Birth	0.4	0.6	1.9	1.4	1.3	-0.4	0.1	-0.2
Mean Putamen Volume	0.4	0.4	1.1	0.0	-1.0	-0.4	0.6	1.0
Schizophrenia (2014)	0.4	1.0	4.4	0.6	0.2	-2.1	0.9	0.6
Blood Red Count	0.4	3.4	17.1	-4.1	-0.2	1.6	-0.9	-0.5
Hypothyroidism (self reported)	0.4	0.8	4.0	-0.6	0.3	-2.0	-0.6	-0.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.3	-0.3	1.0	0.6	-0.7	-1.1
Impedance of leg (right)	0.4	2.1	5.4	-1.2	-1.3	-2.3	-1.6	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.1	1.0	0.6	-0.3	1.5	1.1
Supplements: Glucosamine	0.4	0.5	2.2	-0.6	-0.4	1.5	0.0	-0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.9	-0.3	0.7	-1.4	-0.3	0.1
Medication: Atenolol	0.4	0.6	1.6	0.2	0.8	-1.3	0.7	0.7
Medication: Levothyroxine sodium	0.4	0.6	2.5	-0.7	0.5	-1.6	-0.7	-0.4
Waist circumference	0.4	1.6	4.0	0.1	0.3	1.9	1.5	2.0
Had menopause	0.4	0.5	1.5	1.0	1.2	0.4	0.7	0.1
Financial difficulties in last 2 years	0.4	0.5	1.3	0.7	-0.1	-0.4	1.1	1.1
Weight	0.4	1.8	5.5	-0.2	-0.0	1.6	1.7	2.4
Number of live births	0.4	0.5	2.4	-0.3	-1.5	0.6	0.5	0.3
Noisy workplace	0.4	0.5	1.8	-0.1	1.3	0.2	0.8	0.8
Medication: Cholesterol lowering	0.4	0.7	1.5	1.2	0.9	0.9	0.8	0.6
Depression (self-reported)	0.4	0.5	1.7	-1.3	-0.2	0.5	-0.7	-0.5
Peak expiratory flow (PEF)	0.4	0.9	4.6	0.4	2.2	0.7	0.3	0.3
Loud music exposure frequency	0.4	0.5	2.2	-0.6	-0.4	1.5	-0.2	-0.2
Leg fat percentage (right)	0.4	1.4	4.3	-1.5	-2.1	-0.6	0.1	1.1
Exposure to tobacco smoke outside home	0.4	0.5	2.6	0.3	0.5	-1.6	-0.1	0.1
Worry too long after embarrassment	0.4	0.6	2.3	-0.2	0.8	1.5	0.3	0.9
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.1	-0.2	0.0	0.9	-1.0	-1.1
Medication: Ibuprofen	0.4	0.4	1.1	-0.4	0.8	0.3	-0.7	-1.0
Medication: Omeprazole	0.4	0.5	2.3	-0.1	1.5	0.5	-0.4	-0.4
Suffer from ‘nerves’	0.4	0.7	2.2	0.0	-0.9	0.4	1.0	1.5
Illnesses of siblings: Diabetes	0.4	0.4	0.9	-0.7	-0.4	-0.7	-1.0	-0.7
Leg fat-free mass (right)	0.4	2.2	5.0	0.6	0.6	2.0	1.9	2.2
Diabetes diagnosed by doctor	0.4	0.7	2.0	1.4	0.4	-0.8	0.8	0.7
Medication for cholesterol	0.4	0.6	1.4	-0.5	0.6	0.6	-1.0	-1.2
Back pain experienced in last month	0.4	0.6	2.4	-0.2	-1.5	-1.1	-0.2	0.1
Leg predicted mass (right)	0.4	2.3	5.2	0.7	0.6	2.0	1.9	2.3
Guilty feelings	0.4	0.5	2.1	-0.4	0.0	1.4	0.7	0.7
Financial situation satisfaction	0.4	0.4	1.0	0.6	-0.7	-0.1	1.0	0.9
Intelligence (Savage-Jansen 2018)	0.3	0.8	3.3	-0.5	-1.8	-0.5	-0.9	-0.5
Neuroticism (Nagel 2018)	0.3	0.6	2.0	-0.8	0.9	1.4	0.1	0.4
Alzheimer’s Disease (including proxy)	0.3	0.5	1.5	0.4	-0.0	0.2	1.2	1.1
Verbal and Numeric Reasoning (VNR)	0.3	0.6	3.0	-0.0	-1.7	-0.2	-0.7	-0.4
Blood Eosinophil Count	0.3	2.6	5.0	-2.2	-1.5	-0.6	-2.2	-1.8
Height	0.3	6.4	11.4	1.4	2.5	3.4	3.1	3.0
Chronotype (morning person)	0.3	0.8	3.1	0.2	-1.8	-1.3	-0.1	0.1
Tanning	0.3	3.2	8.4	-0.2	-2.9	1.4	1.7	2.4
Relative age voice broke	0.3	0.5	2.5	-0.1	-1.6	0.6	0.0	0.2
Serious illness, injury or assault to yourself	0.3	0.3	0.7	0.9	0.3	-0.5	0.7	0.6
Mouth/teeth dental problems	0.3	0.4	1.0	0.3	-1.0	0.7	0.4	0.9
Hip circumference	0.3	1.5	4.3	-2.1	-0.9	1.8	-0.2	0.6
Mouth/teeth dental problems: Dentures	0.3	0.4	1.2	-0.2	-1.1	-1.0	-0.4	-0.5
Prospective memory result	0.3	0.3	0.7	0.4	0.5	-0.7	-0.6	-0.8
Standing height	0.3	2.7	4.8	1.2	1.6	1.5	2.2	2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.4	1.0	1.0	0.2	0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.8	1.3	0.2	0.4	0.3	0.8
Medication: Amlodipine	0.3	0.4	0.9	0.9	0.2	-0.1	1.0	0.7
Body fat percentage	0.3	1.2	3.3	-1.7	-1.8	-0.3	-0.6	0.5
Medication for pain relief, constipation, heartburn	0.3	0.4	1.9	1.4	-0.5	0.2	0.5	0.3
Leg fat mass (right)	0.3	1.2	2.7	-1.1	-1.6	0.5	0.6	1.6
Alcohol intake frequency.	0.3	0.8	1.9	1.2	0.4	-0.1	1.4	1.0
Knee pain experienced in last month	0.3	0.4	1.3	0.6	1.1	-0.8	-0.1	-0.3
Long-standing illness, disability or infirmity	0.3	0.5	1.7	0.5	0.9	-1.3	0.4	0.1
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	0.3	0.1	-1.1	-0.4	-0.8
Hearing aid user	0.3	0.4	1.2	-0.7	-1.1	-0.8	0.1	0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.1	1.0	0.1	-0.8	-0.3	-0.4
Leg fat percentage (left)	0.3	1.0	2.8	-1.3	-1.7	-0.8	-0.2	0.8
Ever depressed for a whole week	0.3	0.4	1.0	-0.7	-0.1	-0.3	-1.0	-0.8
Pack years of smoking	0.3	0.5	1.7	-1.3	-0.7	-0.7	0.1	0.5
Depressed Affect (Nagel 2018)	0.2	0.3	1.6	-0.3	1.3	-0.4	0.3	0.3
Schizophrenia vs Biploar Disorder	0.2	0.3	0.8	-0.0	0.9	-0.2	0.8	0.2
Smoking Status	0.2	0.6	1.7	-1.3	0.6	0.8	-0.8	-0.3
Neuroticism	0.2	0.5	1.9	0.1	0.5	1.4	0.5	0.7
Hearing difficulty/problems: Yes	0.2	0.4	0.8	0.3	0.9	0.5	0.7	0.7
Relative age of first facial hair	0.2	0.5	1.9	1.4	-0.8	-0.1	0.5	0.2
Systolic blood pressure, automated reading	0.2	0.6	1.3	-0.3	-1.0	-0.6	-1.1	-0.8
Trunk fat percentage	0.2	1.0	2.9	-1.7	-1.5	-0.2	-0.8	0.3
Current tobacco smoking	0.2	0.4	0.8	0.8	0.1	-0.4	0.6	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.8	-0.3	-0.5	0.1	-0.9	-0.5
Body mass index (BMI)	0.2	0.7	1.8	-0.8	-0.8	1.0	0.6	1.3
Number of incorrect matches in round	0.2	0.4	1.7	0.1	1.3	-0.5	-0.5	-0.2
Alcohol usually taken with meals	0.2	0.3	0.9	0.8	-0.1	0.9	0.3	-0.4
Nervous feelings	0.2	0.3	1.4	-0.4	-1.2	-0.3	-0.2	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.8	0.9	-0.0	0.1	0.6	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.3	1.1	0.4	-0.2	-0.2	1.1	0.9
Qualifications: None of the above	0.2	0.3	1.7	-0.2	-0.4	1.3	0.3	-0.1
Neuroticism score	0.2	0.4	1.3	-0.0	-0.3	1.1	0.4	0.9
Arm fat percentage (right)	0.2	0.6	1.9	-1.4	-1.2	0.3	-0.5	0.4
Hair/balding pattern: Pattern 3	0.2	0.4	1.0	-0.0	-0.2	0.3	1.0	1.0
Pulse rate	0.2	0.4	1.3	0.8	1.1	0.2	0.3	0.2
Tense / ‘highly strung’	0.2	0.4	0.7	0.6	-0.3	0.9	0.7	0.8
Headache pain in last month	0.2	0.3	0.8	-0.1	0.6	-0.9	0.7	0.7
Comparative body size at age 10	0.2	0.5	1.6	-0.3	1.3	1.1	-0.0	0.5
Qualifications: College or University degree	0.2	0.6	1.8	1.3	1.1	-0.4	-0.3	-0.8
Eye problems/disorders: None of the above	0.2	0.2	1.1	0.3	-0.4	1.0	-0.0	0.2
Whole body fat mass	0.2	0.8	1.6	-1.2	-1.2	0.6	0.2	1.1
Overall health rating	0.2	0.4	1.4	-0.1	0.6	-0.1	0.7	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.0	-1.0	-0.6	0.9	0.0	0.5
Arm fat percentage (left)	0.2	1.0	2.7	-1.6	-1.6	0.1	-0.6	0.3
Ever had bowel cancer screening	0.2	0.2	1.0	-0.1	0.2	1.0	-0.2	-0.2
Qualifications: nursing, teaching	0.2	0.3	0.9	0.1	-0.5	0.6	0.4	1.0
Average weekly champagne plus white wine intake	0.2	0.3	0.7	-0.6	0.8	-0.5	-0.4	0.3
Commuting to job workplace: Public transport	0.2	0.2	0.5	0.4	0.3	-0.7	-0.4	-0.4
Commuting to job workplace: Cycle	0.2	0.2	1.0	0.3	-0.3	0.3	-1.0	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.0	0.5	1.0	-0.1	0.2	0.2
Alcohol drinker status: Previous	0.2	0.3	0.6	-0.4	-0.8	0.2	0.7	0.5
Leg fat mass (left)	0.2	0.8	2.0	-0.8	-1.4	0.3	0.4	1.4
Depression (Nagel 2018)	0.1	0.2	0.7	-0.2	-0.8	-0.2	0.0	0.5
Breast Cancer	0.1	0.4	1.2	0.4	-0.8	-1.1	0.1	0.4
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.4	-0.5	-0.5	0.3	0.2
Heel T-Score	0.1	0.9	3.6	0.3	1.1	1.9	0.6	-0.3
BMI	0.1	0.4	1.2	-0.7	0.0	1.1	0.4	0.8
Systolic Blood Pressure	0.1	0.5	1.4	-0.8	-1.2	-0.4	-0.9	-0.2
Number of treatments/medications taken	0.1	0.3	0.8	-0.9	-0.2	0.8	0.3	0.3
Sensitivity / hurt feelings	0.1	0.1	0.4	-0.4	0.1	0.6	-0.3	0.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.5	-0.7	0.2	0.1	-0.1	0.4
Multivitamins +/- minerals	0.1	0.2	0.5	-0.3	-0.7	0.5	-0.1	-0.5
Sitting height	0.1	0.6	2.4	-0.2	0.1	0.5	1.0	1.5
High blood pressure (mother)	0.1	0.1	0.3	-0.1	0.1	-0.3	0.5	0.6
Trunk fat mass	0.1	0.6	1.2	-1.1	-1.1	0.4	0.1	1.0
Time employed in main current job	0.1	0.1	0.4	0.6	0.2	0.3	0.3	0.3
Father’s age at death	0.1	0.1	0.2	0.5	0.1	0.2	-0.2	-0.3
Happiness	0.1	0.1	0.2	-0.1	-0.1	-0.5	0.2	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.5	0.7	-0.1	-0.4	0.2	0.5
Arm fat mass (right)	0.1	0.6	1.7	-0.7	-0.5	0.9	0.6	1.3
Glaucoma (self-reported)	0.1	0.1	0.2	-0.4	0.3	-0.5	0.1	-0.0
Health satisfaction	0.1	0.2	0.7	0.5	0.0	-0.9	-0.4	-0.2
Heart disease (mother)	0.1	0.1	0.3	-0.3	-0.1	-0.6	0.0	0.4
Pulse rate, automated reading	0.1	0.4	1.4	1.2	0.3	0.0	0.4	0.7
Commuting to job workplace: Walk	0.1	0.1	0.3	0.4	-0.2	0.1	0.6	0.1
Osteoarthritis (self-reported)	0.1	0.2	0.3	0.3	-0.4	-0.5	0.6	0.6
Smoking status: Current	0.1	0.1	0.3	0.5	0.2	-0.2	0.4	0.6
Arm fat mass (left)	0.1	0.5	1.2	-0.9	-0.7	0.7	0.3	1.1
Miserableness	0.1	0.1	0.5	-0.7	0.3	-0.2	0.1	0.1
Ever taken oral contraceptive pill	0.1	0.1	0.5	-0.5	0.0	0.7	0.0	0.1
Diastolic blood pressure, automated reading	0.1	0.4	1.7	-1.3	-0.1	-0.2	-0.6	0.1
Pain experienced in last month	0.1	0.2	0.5	-0.1	-0.6	0.7	0.3	0.4
Hair Pigment	0.0	0.5	1.2	0.3	-0.1	-1.0	-0.9	-1.1
Supplements: Zinc	0.0	0.1	0.1	0.0	-0.1	-0.4	-0.2	-0.4
Diabetes (mother)	0.0	0.1	0.3	0.1	0.6	-0.1	-0.0	-0.1
Shortness of breath walking on level ground	0.0	0.0	0.1	-0.3	0.2	0.2	-0.0	-0.1
Mood swings	0.0	0.1	0.2	-0.5	-0.2	-0.3	-0.1	0.3

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Trait associations