TWAS hub - IL27RA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2940	0.0540	1.4e-07	0.122	0.075	0.121	0.113	0.111	1.3e-14	1.9e-09	1.6e-14	1.2e-13	1.9e-13
2	GTEx	Adipose Subcutaneous	0.2860	0.0530	1.2e-08	0.155	NA	0.196	NA	0.157	1.1e-12	NA	6.6e-16	NA	8.1e-13
3	GTEx	Adipose Visceral Omentum	0.2080	0.0680	2.1e-03	0.123	NA	0.119	NA	0.137	6.1e-07	NA	9.6e-07	NA	1.4e-07
4	GTEx	Breast Mammary Tissue (Male)	0.3573	0.1395	9.0e-03	-0.008	NA	-0.006	NA	-0.013	5.2e-01	NA	4.6e-01	NA	9.2e-01
5	GTEx	Breast Mammary Tissue (Female)	0.1993	0.0947	1.7e-02	0.017	NA	0.024	NA	0.009	9.9e-02	NA	6.5e-02	NA	1.6e-01
6	YFS	Blood	0.0476	0.0122	4.9e-08	0.050	0.029	0.042	0.048	0.047	4.2e-16	5.1e-10	1.1e-13	2.4e-15	3.6e-15

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	5	6
Medication: Ibuprofen (e.g. Nurofen)	3.2	4.0	7.7	2.0	2.0	2.8	-1.2	-2.6
Medication: Levothyroxine sodium	3.1	5.3	11.4	-1.7	-3.2	-3.4	-0.2	2.8
Hypothyroidism/myxoedema (self-reported)	3.1	6.1	12.1	-2.6	-3.1	-3.5	-0.9	2.7
Pack years of smoking	2.8	4.1	6.6	-1.9	-2.6	-2.2	-1.8	2.5
Tinnitus: Yes, now most or all of the time	2.5	3.0	7.2	-0.2	-1.9	-2.4	-0.9	2.7
Pack years adult smoking proportion	2.4	3.6	5.9	-1.7	-2.4	-2.0	-1.8	2.3
Happiness	2.4	2.9	9.3	-3.0	-1.6	-1.7	-0.5	1.4
Respiratory disease	2.3	5.1	11.0	0.6	3.3	2.9	-0.1	-3.2
Lung FEV1/FVC ratio	2.3	11.6	26.5	-2.6	-4.5	-3.9	-1.2	5.2
Ever taken oral contraceptive pill	2.3	2.5	5.3	-2.3	-1.9	-1.8	-0.8	1.6
Medication: Ibuprofen	2.2	2.6	5.8	1.4	1.7	2.4	-1.0	-1.9
Hypothyroidism (self reported)	2.1	4.8	9.5	-2.2	-2.8	-3.1	-1.4	2.2
Severe depression (siblings)	2.0	2.2	8.0	-2.8	-1.6	-1.1	-0.4	1.1
Medication: Bendroflumethiazide	2.0	3.0	8.6	-1.4	-1.6	-1.4	-2.9	1.7
Gout (self-reported)	1.7	2.3	6.7	-0.5	-2.6	-2.0	-0.3	1.6
Medication: Simvastatin	1.6	2.3	4.4	-1.3	-1.8	-1.2	-1.8	2.1
Age at last live birth	1.6	2.3	5.1	1.8	2.3	1.7	-0.0	-1.6
Had menopause	1.5	1.8	5.0	-2.2	-1.1	-1.5	-0.9	1.3
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	6.2	2.5	1.3	1.3	-0.6	-1.4
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.8	-0.4	-1.9	-1.6	-1.2	1.4
Frequency of depressed mood in last 2 weeks	1.3	1.8	3.5	-1.4	-1.7	-1.6	0.3	1.9
Systolic blood pressure, automated reading	1.3	3.8	7.1	-2.7	-2.6	-2.0	0.1	2.2
Bilateral oophorectomy (both ovaries removed)	1.3	1.6	3.3	-0.9	-1.4	-1.8	1.0	1.5
Breastfed as a baby	1.3	1.6	2.8	0.7	1.7	1.2	-1.5	-1.6
Medication: Allopurinol	1.3	1.7	4.5	-0.1	-2.1	-1.9	-0.4	1.4
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.4	0.1	-1.8	-1.7	1.2	1.4
Supplements: Calcium	1.3	1.5	3.1	1.6	0.6	1.1	1.8	-1.2
Chronotype (morning person)	1.2	2.7	6.0	-1.1	-2.4	-1.7	-2.0	1.3
Father’s age at death	1.2	1.6	2.7	1.6	1.5	1.3	0.5	-1.6
Noisy workplace	1.2	1.5	5.3	0.2	-1.1	-1.5	-0.6	2.3
Asthma	1.2	2.3	6.1	0.4	2.0	1.8	-0.2	-2.5
Angina	1.1	1.4	3.4	-0.6	-1.0	-1.3	-1.8	1.3
Taking other prescription medications	1.1	1.7	3.2	0.3	-1.7	-1.8	-1.0	1.8
Hearing difficulty/problems with background noise	1.1	1.8	4.5	2.1	1.3	1.3	-0.6	-1.7
Exposure to tobacco smoke at home	1.1	1.3	5.8	-2.4	-0.1	-0.2	1.3	-0.0
Peak expiratory flow (PEF)	1.1	2.6	5.3	1.3	-2.1	-2.0	0.6	2.3
Pulse wave reflection index	1.1	1.3	3.5	-0.7	-1.2	-1.9	-0.3	1.5
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.4	-0.6	-1.3	-1.5	1.2	1.6
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.5	-2.1	-1.1	-0.6	-1.5	0.4
Angina (self-reported)	1.1	1.4	3.9	-0.6	-1.0	-1.3	-2.0	1.3
Migraine (self-reported)	1.1	1.3	3.5	-0.1	0.8	1.6	1.1	-1.9
Osteoporosis (self-reported)	1.1	1.4	4.0	2.0	1.2	1.2	-0.4	-1.1
Systolic Blood Pressure	1.0	4.8	10.9	-2.5	-3.3	-2.2	-0.3	2.6
Ever had hysterectomy (womb removed)	1.0	1.1	2.8	0.0	-1.2	-1.1	-1.1	1.7
Medication for hormone replacement therapy	1.0	1.1	2.3	0.8	1.1	1.5	0.8	-1.3
Medication: Ramipril	1.0	1.3	2.9	-1.6	-1.7	-0.9	-0.6	0.9
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.1	-0.8	-1.4	-1.3	-0.6	1.4
Exposure to tobacco smoke outside home	1.0	1.3	2.5	1.6	1.3	1.2	-0.9	-1.1
Medication: Blood pressure	1.0	1.8	3.0	-1.0	-1.6	-1.4	-1.7	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.8	-0.3	-0.8	-2.0	-0.6	1.5
Diabetes (father)	0.9	1.2	3.8	-0.8	-1.9	-0.9	-0.9	1.1
Current tobacco smoking	0.9	1.4	2.1	-1.3	-1.4	-1.2	-1.2	1.4
Mouth/teeth dental problems	0.9	1.4	3.0	1.7	1.3	1.1	1.2	-1.0
Pulse rate	0.9	1.6	3.1	1.8	0.9	1.6	0.0	-1.8
Medication: Cholesterol lowering	0.9	1.5	3.6	-1.1	-1.5	-1.2	-0.6	1.9
Depression (self-reported)	0.9	1.1	4.5	2.1	0.3	0.3	-1.3	-0.2
Medication: Paracetamol	0.9	1.4	4.6	2.1	-0.0	0.0	-1.9	-0.6
Medication: Seretide 50 evohaler	0.9	1.0	2.1	0.1	1.2	1.1	-1.4	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.6	-0.0	-0.8	-0.9	-1.6	1.6
Friendships satisfaction	0.9	1.2	3.0	-0.6	1.1	0.9	1.7	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	6.2	0.4	1.0	0.8	-2.5	-0.8
Asthma (self-reported)	0.9	1.8	4.8	0.4	1.8	1.6	-0.2	-2.2
Smoking status: Current	0.9	1.5	2.3	-1.2	-1.5	-1.2	-1.2	1.5
Illnesses of father: High blood pressure	0.9	1.1	4.1	2.0	0.7	0.9	-0.5	-1.0
Age started oral contraceptive pill	0.9	1.1	3.1	-1.8	1.0	1.0	0.3	-1.2
Cholesterol lowering medication	0.9	1.4	4.0	-1.3	-1.1	-0.6	-2.0	1.0
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.4	-0.2	2.1	2.0	0.1	-1.6
HbA1C	0.8	0.9	4.3	0.4	0.8	0.5	-2.1	0.1
Blood White Count	0.8	6.1	10.2	-3.2	2.1	2.5	-2.3	-3.2
Financial difficulties in last 2 years	0.8	1.1	2.5	-0.8	-1.3	-1.0	-0.7	1.6
Alcohol intake versus 10 years previously	0.8	1.1	2.4	0.8	-1.6	-1.2	-0.8	1.4
Loud music exposure frequency	0.8	0.8	2.7	1.1	0.6	0.5	1.6	-0.7
Worry too long after embarrassment	0.8	1.3	5.9	-1.3	0.2	0.3	-2.4	-0.1
Wheeze or whistling in the chest in last year	0.8	1.4	2.9	1.0	1.7	1.3	-1.4	-1.0
Health satisfaction	0.8	1.0	2.7	0.4	1.1	1.3	0.4	-1.6
Medication for cholesterol	0.8	1.2	4.5	0.9	-0.4	-1.0	2.1	0.8
Average weekly champagne plus white wine intake	0.8	1.1	3.2	0.4	0.7	1.0	1.3	-1.8
Ever had prostate specific antigen (PSA) test	0.8	1.0	2.2	-0.5	-0.7	-1.0	-1.5	1.4
Pain experienced in last month	0.8	1.3	2.5	-0.9	-1.6	-1.5	0.7	1.3
Average weekly spirits intake	0.7	0.9	3.2	-1.8	-0.7	-0.8	-0.4	0.8
Townsend deprivation index at recruitment	0.7	1.0	2.4	-1.1	-0.9	-1.2	0.5	1.6
Medication: Atenolol	0.7	0.9	2.5	-1.5	-0.8	-0.4	-1.6	-0.1
Hair/balding pattern: Pattern 3	0.7	1.1	3.9	-2.0	-0.8	-0.8	1.0	0.6
Headache pain in last month	0.7	1.3	7.2	0.5	0.2	0.2	-2.7	-0.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.9	0.6	1.4	1.2	0.8	-1.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	5.3	0.3	0.2	0.1	-2.3	0.2
Age at first live birth	0.7	1.3	2.1	1.5	1.5	1.3	-0.4	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.0	0.0	-1.3	-1.4	-0.4	0.9
Number of full sisters	0.7	0.9	2.9	-1.7	-1.1	-0.9	0.2	0.7
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	3.1	0.1	0.6	0.6	1.8	-1.2
Illnesses of father: Heart disease	0.7	0.9	1.5	1.2	1.1	1.2	-0.6	-1.0
Wears glasses or contact lenses	0.7	0.8	1.5	0.5	-1.1	-1.2	-0.9	0.9
Risk taking	0.7	1.0	4.2	2.0	0.7	1.0	0.6	-0.1
Diastolic blood pressure, automated reading	0.7	2.3	5.4	-2.3	-2.1	-1.4	0.7	1.3
Vascular/heart problems diagnosed by doctor	0.7	2.0	7.0	1.1	1.3	1.0	2.6	-1.2
Basal cell carcinoma (self-reported)	0.7	0.9	2.7	-1.1	-0.5	-0.5	-1.7	1.0
Mean Putamen Volume	0.6	0.7	1.3	-0.9	-0.6	-1.2	-0.3	1.1
Blood Red Count	0.6	5.4	10.2	3.2	2.7	2.4	1.1	-2.8
Number of treatments/medications taken	0.6	1.1	4.3	0.2	-0.9	-0.8	-2.1	0.8
Relative age of first facial hair	0.6	1.2	3.4	-0.0	1.9	1.4	0.6	-1.2
Supplements: Zinc	0.6	0.7	2.1	-0.2	0.9	0.7	1.4	-0.7
Hand grip strength (right)	0.6	1.6	2.9	0.9	1.7	1.3	1.7	-1.3
High blood pressure	0.6	1.8	6.5	-0.9	-1.2	-1.0	-2.5	1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	1.2	1.0	1.1	0.0	-0.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	3.2	-1.8	-0.7	-0.6	0.2	0.4
Medication: Lansoprazole	0.6	0.7	2.5	1.6	-0.4	-0.3	-1.2	0.3
Hair/balding pattern: Pattern 4	0.6	1.4	3.7	0.2	-1.5	-1.9	-0.3	1.6
Chronic bronchitis/emphysema (mother)	0.6	0.7	3.3	-0.4	-0.7	0.3	1.8	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.7	0.1	-0.6	-0.8	-1.3	1.3
Number of children fathered	0.6	0.7	1.7	0.6	-0.6	-0.8	-1.3	0.8
Medication: Omeprazole	0.6	0.8	1.7	-1.3	-1.0	-0.8	-0.8	0.8
Chest pain or discomfort	0.6	0.9	1.5	-0.7	1.2	1.2	-1.1	-1.0
Had major operations	0.6	0.8	1.7	0.3	-1.1	-1.0	-1.3	0.8
Family relationship satisfaction	0.6	0.7	3.8	-2.0	0.2	0.4	0.1	-0.4
Medication: Aspirin	0.6	0.7	1.3	-0.8	-1.0	-1.1	0.7	1.2
Smoking status: Previous	0.6	0.9	1.6	1.3	0.9	0.8	1.3	-0.8
Loneliness, isolation	0.6	0.8	1.9	1.2	1.4	0.9	0.3	-0.4
Medication: Paracetamol	0.6	0.9	4.3	2.1	-0.1	0.1	-0.6	-0.9
Medication: Atorvastatin	0.6	0.8	3.1	-1.8	-0.9	-0.6	0.6	-0.0
Alcohol drinker status: Never	0.6	0.7	1.9	0.2	-1.0	-1.1	0.1	1.4
Commuting to job workplace: Cycle	0.6	0.7	2.0	0.2	0.8	1.0	1.4	-0.9
Depression (Nagel 2018)	0.5	0.8	1.5	-1.1	-1.1	-1.2	-0.2	1.0
Irritable Bowel Disease (IBD)	0.5	1.1	2.7	1.6	1.4	1.3	0.2	-0.2
Blood Eosinophil Count	0.5	3.7	13.6	-3.7	-0.6	0.2	-2.5	-1.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.8	1.7	0.9	1.3	0.3	-0.5
Alcohol usually taken with meals	0.5	0.7	2.1	0.9	0.7	0.9	-1.4	-0.6
Fluid intelligence score	0.5	1.0	2.2	-0.1	1.5	1.3	0.3	-1.5
Time employed in main current job	0.5	0.6	1.6	-1.2	-0.5	-0.6	1.1	0.7
Mouth/teeth dental problems: Dentures	0.5	0.8	1.6	-1.2	-0.9	-1.1	-0.1	1.3
Prospective memory result	0.5	0.7	3.0	1.7	-0.8	-0.3	-0.6	0.1
Birth weight of first child	0.5	1.0	2.7	1.6	1.3	0.9	0.5	-0.6
High blood pressure (siblings)	0.5	0.8	1.4	-1.2	-1.0	-0.9	0.5	1.1
Comparative body size at age 10	0.5	1.4	3.9	-2.0	-1.5	-1.1	-1.1	0.5
Number of full brothers	0.5	0.7	1.3	0.1	1.1	0.8	1.0	-1.1
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.1	-1.1	-1.0	-0.6	-0.8	0.4
Hypertension (Self-reported)	0.5	1.3	5.8	-0.8	-0.8	-0.6	-2.4	0.8
Eye problems/disorders: Cataract	0.5	0.5	1.3	0.1	0.8	0.7	0.8	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.7	-0.3	-0.2	-0.5	-1.3	1.2
Back pain experienced in last month	0.5	0.7	1.9	0.9	1.4	0.8	0.5	-0.9
Guilty feelings	0.5	0.7	1.2	-0.9	-1.1	-0.6	-0.9	1.0
Medication: Blood pressure	0.5	0.9	4.9	-0.6	-0.4	0.1	-2.2	-0.1
High cholesterol (Self-reported)	0.5	0.8	2.9	-1.1	-0.7	-0.1	-1.7	0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.2	0.3	-0.8	-0.8	-0.4	1.5
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.3	-0.1	1.5	1.3	1.2	-1.1
Ulcerative Colitis (UC)	0.4	0.7	1.6	1.3	1.2	1.0	0.2	-0.3
Fasting Glucose	0.4	0.5	1.5	0.1	-0.6	-0.8	-0.5	1.2
HDL Cholesterol	0.4	0.7	1.5	0.2	-1.2	-1.1	0.0	1.1
Primary Biliary Cirrhosis	0.4	0.6	2.2	-1.5	0.4	0.0	-0.8	-0.9
Heel T-Score	0.4	3.4	6.9	-0.2	2.2	2.4	1.7	-2.6
Waist Hip Ratio (WHR)	0.4	1.6	5.1	0.8	1.8	2.2	-0.0	-0.9
Hand grip strength (left)	0.4	1.2	2.5	1.5	1.0	0.5	1.6	-0.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.9	1.4	0.2	-0.0	0.7	-0.1
Medication: Co-codamol	0.4	0.5	2.1	1.4	-0.0	-0.8	0.5	0.0
Trunk fat percentage	0.4	1.6	3.7	-1.1	-1.3	-1.2	-1.9	1.1
Average weekly fortified wine intake	0.4	0.4	0.9	-0.8	-1.0	-0.8	-0.0	0.6
Age when periods started (menarche)	0.4	0.9	4.3	-0.9	-0.1	-0.4	2.1	0.0
Stomach or abdominal pain in last month	0.4	0.5	2.3	1.5	0.3	0.6	-0.0	0.4
Chronic bronchitis/emphysema (father)	0.4	0.5	1.8	-1.4	0.0	0.7	0.3	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.7	-1.6	0.1	-0.0	-0.9	0.3
Number of live births	0.4	0.6	1.3	0.7	0.8	0.7	1.1	-0.6
Tense / ‘highly strung’	0.4	0.6	3.8	-1.9	0.1	0.3	0.1	0.1
Glaucoma (self-reported)	0.4	0.4	1.7	-1.3	-0.6	-0.4	-0.2	0.5
Birth weight	0.4	0.8	3.5	1.9	0.1	-0.5	0.3	1.0
Body fat percentage	0.4	1.5	3.8	-1.4	-1.3	-1.0	-2.0	0.9
Leg fat percentage (right)	0.4	1.5	3.7	-1.9	-1.2	-0.7	-1.7	0.5
Medication for pain relief, constipation, heartburn	0.4	0.6	2.4	-1.0	-0.1	-0.4	1.5	0.2
Neck or shoulder pain in last month	0.4	0.5	1.8	1.3	-0.1	-0.5	-0.7	0.7
Mean time to correctly identify matches	0.4	0.7	2.8	-0.9	0.2	0.6	1.7	-0.5
Whole body fat mass	0.4	1.5	2.7	-1.0	-1.6	-1.3	-1.4	1.2
Knee pain experienced in last month	0.4	0.6	1.2	0.4	1.0	0.5	-0.9	-1.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.1	-0.5	-0.6	-0.1	1.4	0.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.5	0.8	-0.2	-1.0	1.2	0.5
Mother’s age at death	0.4	0.5	1.5	-1.1	0.0	0.0	1.2	-0.5
Medication: Lisinopril	0.4	0.5	2.4	0.7	0.1	0.4	-1.6	-0.2
Leg fat percentage (left)	0.4	1.5	3.8	-1.8	-1.1	-0.6	-2.0	0.4
Number of operations (self-reported)	0.4	0.6	2.3	1.5	0.2	-0.4	-1.0	0.3
Myopia	0.4	0.6	3.0	-0.0	0.8	0.2	1.7	0.0
Crohns Disease (2017)	0.3	0.7	1.5	1.1	1.2	1.2	0.4	-0.3
Reaction Time	0.3	0.5	2.2	-0.7	-0.2	0.4	1.5	-0.4
Age at First Birth	0.3	0.4	1.8	-0.3	-0.7	-0.3	-1.3	0.3
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	0.2	0.8	0.9	0.0	-1.0
Neuroticism (2016)	0.3	0.5	1.7	-0.5	-0.3	-1.0	0.0	1.3
Blood Platelet Count	0.3	3.2	14.0	-3.7	0.7	1.1	-1.5	-1.0
Cardiovascular Disease	0.3	0.9	2.3	-0.8	-1.3	-0.4	-1.5	0.6
Sensitivity / hurt feelings	0.3	0.5	2.1	-0.4	0.7	0.2	-1.4	-0.1
Vitamin and mineral supplements	0.3	0.5	0.9	-0.8	0.7	1.0	0.5	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.7	-1.1	0.1	-0.1	1.6	-0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.0	0.9	0.0	0.1	1.0	-0.2
Body mass index (BMI)	0.3	1.2	3.7	-1.0	-1.4	-0.7	-1.9	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.1	-0.9	-0.0	0.1	1.5	-0.7
Qualifications: None of the above	0.3	0.6	2.3	0.3	-0.1	-0.9	0.5	1.5
Heart attack	0.3	0.4	1.5	0.4	-0.6	-0.5	-0.3	1.2
Allergy	0.3	0.6	2.2	0.6	-0.6	-0.8	0.1	1.5
Hip circumference	0.3	1.2	4.3	-0.2	-1.3	-0.9	-2.1	0.5
Worrier / anxious feelings	0.3	0.5	1.9	-1.0	0.2	-0.0	-1.4	0.1
Falls in the last year	0.3	0.5	1.1	1.0	0.9	0.9	-0.1	0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.6	1.6	0.7	0.5	0.6	-0.4
Lung cancer (father)	0.3	0.3	0.9	-0.9	0.1	-0.2	0.8	-0.4
Arm fat mass (right)	0.3	1.2	2.9	-0.8	-1.5	-0.9	-1.7	0.9
Length of working week for main job	0.3	0.3	1.3	1.1	0.1	0.5	-0.2	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.7	-0.6	-0.8	-0.5	0.9	0.4
Eye problems/disorders: None of the above	0.3	0.4	0.9	-0.2	-0.7	-1.0	-0.1	0.9
Emphysema/chronic bronchitis	0.3	0.3	1.3	-0.6	-0.0	-0.3	-1.1	0.2
Leg fat mass (right)	0.3	1.2	2.7	-1.2	-1.3	-0.8	-1.7	0.6
Alcohol intake frequency.	0.3	0.7	1.6	0.3	-0.5	-1.0	-1.0	1.3
Diabetes diagnosed by doctor	0.3	0.5	1.4	1.2	-0.7	-0.5	-0.3	0.8
Mineral and other dietary supplements	0.3	0.4	0.8	-0.8	0.6	0.6	-0.9	-0.6
Medication: Aspirin	0.3	0.4	0.7	-0.5	-0.7	-0.8	0.4	0.9
Hearing aid user	0.3	0.3	1.3	0.2	0.2	-0.4	0.4	1.1
Commuting to job workplace: Public transport	0.3	0.3	0.8	0.1	0.9	0.8	-0.5	-0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.8	0.0	-0.2	-0.4	-1.3	0.7
Average weekly beer plus cider intake	0.3	0.4	1.4	1.2	-0.1	0.6	0.3	-0.5
Heart disease (siblings)	0.3	0.4	0.9	-0.4	1.0	0.7	-0.9	-0.1
Leg fat mass (left)	0.3	1.2	3.5	-1.1	-1.2	-0.7	-1.9	0.5
Neuroticism (Nagel 2018)	0.2	0.4	1.8	-0.4	-0.3	-0.3	-1.3	0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.0	0.5	0.6	-0.8	-0.1
Breast Cancer	0.2	0.5	1.2	-0.1	-1.1	-1.0	0.1	0.8
Ovarian Cancer	0.2	0.3	1.0	1.0	0.7	0.5	0.0	-0.4
Rheumatoid Arthritis	0.2	0.2	0.8	0.0	0.0	-0.7	0.0	0.9
BMI	0.2	1.1	2.9	-1.1	-1.4	-0.7	-1.7	0.4
Lung FVC	0.2	1.2	2.5	0.6	1.6	1.1	1.2	-1.4
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.7	-1.3	-0.2	-0.1	-0.0	0.4
Diabetes (mother)	0.2	0.2	0.5	0.7	-0.4	-0.4	0.5	0.5
Maternal smoking around birth	0.2	0.2	0.7	0.8	0.4	0.3	0.7	-0.1
Fed-up feelings	0.2	0.4	0.6	0.8	0.7	0.7	0.5	-0.7
Serious illness, injury or assault to yourself	0.2	0.3	0.7	-0.3	0.7	0.5	-0.0	-0.8
Hayfever, allergic rhinitis or eczema	0.2	0.5	2.0	-0.3	0.2	1.0	0.1	-1.4
Multivitamins +/- minerals	0.2	0.3	0.7	0.4	-0.5	-0.9	-0.0	0.6
Supplements: Glucosamine	0.2	0.3	0.6	0.5	0.8	0.7	-0.1	-0.4
High blood pressure (mother)	0.2	0.3	1.1	-0.6	-0.2	-0.4	1.0	0.0
Trunk fat mass	0.2	1.1	1.8	-0.9	-1.3	-1.1	-1.3	1.0
Waist circumference	0.2	0.7	3.6	-0.2	-0.7	-0.0	-1.9	0.4
Number of incorrect matches in round	0.2	0.3	1.5	0.1	0.1	-0.1	1.2	-0.5
Past tobacco smoking	0.2	0.4	1.5	-1.2	-0.6	-0.6	-0.5	0.4
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	-0.6	0.3	0.3	-0.5	-0.7
Had other major operations	0.2	0.2	0.4	0.7	0.5	0.4	0.1	-0.6
Pain all over the body in last month	0.2	0.2	0.9	-0.7	-0.1	-0.2	0.9	0.1
Arm fat percentage (right)	0.2	1.0	4.2	-0.7	-0.8	-0.4	-2.0	0.5
Illnesses of mother	0.2	0.3	0.6	0.7	0.2	-0.1	-0.8	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	2.1	1.0	0.2	-0.0	1.5	0.1
Pulse wave Arterial Stiffness index	0.2	0.2	0.7	0.8	0.6	0.4	0.0	-0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.4	0.8	-0.4	-0.4	1.2	0.1
Forced vital capacity (FVC), Best measure	0.2	0.8	1.8	1.2	0.9	0.6	1.4	-0.7
Heart disease (mother)	0.2	0.3	0.7	-0.2	-0.8	-0.7	0.6	0.3
Pulse rate, automated reading	0.2	0.7	1.7	0.9	0.7	1.3	-0.2	-1.0
Suffer from ‘nerves’	0.2	0.3	1.0	-1.0	-0.4	-0.6	-0.2	0.7
Leg pain on walking	0.2	0.3	1.1	-0.5	0.6	0.3	0.3	-1.0
Arm fat percentage (left)	0.2	0.7	3.1	-0.8	-0.6	-0.2	-1.8	0.4
Long-standing illness, disability or infirmity	0.2	0.3	0.9	-0.1	0.7	0.5	-0.9	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.7	0.3	-0.3	-0.1	0.7	0.8
Commuting to job workplace: Walk	0.2	0.2	1.1	1.0	0.2	-0.2	0.4	0.2
Breast cancer (self-reported)	0.2	0.3	0.8	0.3	0.9	0.4	0.6	-0.3
Osteoarthritis (self-reported)	0.2	0.3	0.8	-0.0	0.5	0.8	0.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.9	-0.7	-0.8	-0.7	-0.4	0.9
Arm fat mass (left)	0.2	0.9	2.4	-0.7	-1.2	-0.7	-1.6	0.7
Number of self-reported non-cancer illnesses	0.2	0.3	0.5	0.7	0.7	0.6	-0.2	-0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	-0.8	-0.2	-0.2	-0.5	0.5
Irritability	0.2	0.3	1.3	-1.2	-0.2	-0.0	0.6	0.3
Fractured/broken bones in last 5 years	0.2	0.2	0.8	0.9	-0.5	-0.3	0.3	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.2	-0.6	-0.4	-0.7	0.6
Bipolar Disorder (2018)	0.1	0.1	0.6	0.0	0.0	0.0	0.0	-0.8
Worry (Nagel 2018)	0.1	0.2	1.1	0.1	0.4	0.3	-1.1	0.2
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.3	0.5	0.4	-0.3	-0.3
Prostate Cancer	0.1	0.1	0.5	0.1	-0.1	-0.3	0.7	0.5
Lupus	0.1	0.1	0.4	-0.1	0.4	0.2	-0.6	-0.4
Schizophrenia (2014)	0.1	0.2	0.6	0.0	0.0	0.8	0.0	-0.7
Triglycerides	0.1	0.1	0.3	0.4	0.4	0.5	0.0	-0.5
Ulcerative Colitis	0.1	0.2	1.2	0.0	0.0	0.0	0.0	-1.1
Allergy or Eczema	0.1	0.3	0.7	-0.8	-0.5	0.4	-0.3	-0.7
Neuroticism	0.1	0.2	0.3	-0.6	-0.3	-0.4	-0.3	0.6
Hair Pigment	0.1	1.9	5.8	0.4	1.1	1.8	-1.0	-2.4
Tanning	0.1	1.2	3.8	-0.4	0.6	1.6	0.4	-2.0
Hearing difficulty/problems: Yes	0.1	0.1	0.5	0.2	-0.3	-0.7	-0.2	0.3
Medication: Metformin	0.1	0.2	0.4	0.6	-0.5	-0.4	-0.4	0.5
Impedance of leg (right)	0.1	0.5	0.9	-0.9	-0.3	-1.0	0.4	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.5	-0.5	-0.4	-0.4	-0.2	0.7
Relative age voice broke	0.1	0.1	0.4	-0.1	0.3	0.1	-0.6	0.4
Qualifications: CSEs or equivalent	0.1	0.2	0.7	-0.2	-0.3	0.1	0.9	0.3
Sitting height	0.1	0.9	1.5	1.2	-0.4	-1.1	1.1	1.1
Impedance of leg (left)	0.1	0.3	0.6	-0.8	-0.2	-0.7	-0.1	0.7
Forced vital capacity (FVC)	0.1	0.3	0.9	0.9	0.5	0.3	0.5	-0.3
Diabetes (self-reported)	0.1	0.2	0.8	0.9	0.3	0.4	0.0	-0.1
Neuroticism score	0.1	0.2	0.5	-0.5	0.7	0.3	-0.7	0.2
Weight	0.1	0.5	1.2	-0.2	-1.1	-0.7	-0.9	0.6
Impedance of arm (right)	0.1	0.3	0.9	0.7	1.0	0.4	0.0	0.3
Trunk fat-free mass	0.1	0.4	1.3	0.7	-0.8	-0.5	1.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	-0.1	0.6	0.2	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.9	0.4	-0.8	-0.8	0.5	0.9
Impedance of arm (left)	0.1	0.5	2.0	0.7	1.4	0.6	0.5	0.1
Trunk predicted mass	0.1	0.4	1.3	0.7	-0.8	-0.4	1.1	0.2
Standing height	0.1	0.8	2.2	1.3	0.1	-0.6	1.5	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.2	-0.5	-0.2	-0.3	0.6
Blood clot in the leg (DVT)	0.1	0.2	0.5	0.7	0.4	0.2	0.0	-0.4
Medication: Amlodipine	0.1	0.1	0.2	-0.2	0.4	0.1	-0.4	0.3
Arm fat-free mass (right)	0.1	0.4	1.1	-0.3	-1.1	-0.6	0.7	0.2
Pulse wave peak to peak time	0.1	0.1	0.4	-0.6	-0.5	-0.3	0.2	0.3
Shortness of breath walking on level ground	0.1	0.1	0.3	0.2	-0.1	-0.0	-0.6	0.2
Arm predicted mass (right)	0.1	0.3	1.2	-0.1	-1.1	-0.6	0.7	0.2
Overall health rating	0.1	0.3	1.3	-0.5	0.0	0.2	-1.1	-0.2
Illnesses of siblings: Diabetes	0.1	0.1	0.1	0.1	-0.1	-0.3	-0.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	1.1	0.4	-0.2	-0.2	1.0	0.3
Average weekly red wine intake	0.1	0.1	0.4	-0.5	0.0	-0.0	-0.7	0.5
Mood swings	0.1	0.2	0.5	0.4	0.5	0.2	-0.7	0.4
Medication: Gliclazide	0.1	0.1	0.2	0.2	-0.3	-0.2	-0.1	0.5
Miserableness	0.1	0.1	0.4	0.3	0.6	0.5	-0.0	-0.2
Financial situation satisfaction	0.1	0.2	0.6	-0.8	0.1	0.2	-0.6	-0.0
Ever smoked	0.1	0.2	0.9	0.9	0.0	0.1	0.3	0.0
Arm fat-free mass (left)	0.1	0.4	1.8	0.0	-1.3	-0.8	-0.1	0.4
Ever depressed for a whole week	0.1	0.2	0.8	-0.1	-0.0	0.3	-0.9	-0.4
Unable to work because of sickness or disability	0.1	0.1	0.3	0.4	0.6	0.3	-0.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.4	0.6	0.5	0.3	0.1	-0.4
Alcohol drinker status: Previous	0.1	0.1	0.2	0.5	-0.1	-0.3	-0.0	0.3
Arm predicted mass (left)	0.1	0.4	1.7	-0.1	-1.3	-0.7	-0.0	0.4
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	0.0	0.0	0.5	0.0	-0.4
Depressed Affect (Nagel 2018)	0.0	0.1	0.3	0.5	0.5	-0.1	-0.1	-0.1
Schizophrenia (2018)	0.0	0.0	0.2	0.0	0.0	0.4	0.0	-0.3
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	0.2	0.2	-0.0	0.3	-0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.2	-0.5	-0.1	-0.1	0.0	0.2
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Height	0.0	0.6	1.8	1.3	0.5	0.1	1.4	-0.2
Smoking Status	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.0	0.3
Other serious medical condition/disability diagnosed by doctor	0.0	0.1	0.3	0.0	0.5	0.0	0.3	0.0
Leg fat-free mass (left)	0.0	0.1	0.4	0.5	-0.6	-0.1	0.2	0.0
Leg predicted mass (left)	0.0	0.1	0.3	0.5	-0.5	-0.1	0.1	-0.1
Nervous feelings	0.0	0.1	0.2	-0.4	0.2	0.1	-0.5	0.1
Illnesses of siblings	0.0	0.0	0.1	0.1	-0.3	-0.2	0.0	0.0
Qualifications: College or University degree	0.0	0.1	0.4	-0.4	-0.3	0.2	0.1	-0.6
Comparative height size at age 10	0.0	0.3	0.6	0.8	-0.0	-0.6	-0.3	0.7
Supplements: Vitamin C	0.0	0.1	0.2	-0.5	-0.1	-0.2	0.1	-0.1
Whole body fat-free mass	0.0	0.3	0.6	0.6	-0.8	-0.4	0.7	0.1
Leg fat-free mass (right)	0.0	0.1	0.5	0.7	-0.5	0.0	0.1	-0.1
Ever had bowel cancer screening	0.0	0.0	0.1	0.1	0.3	0.2	0.1	-0.1
Qualifications: nursing, teaching	0.0	0.0	0.1	-0.1	0.2	-0.1	-0.1	-0.4
Whole body water mass	0.0	0.2	0.5	0.5	-0.7	-0.3	0.5	0.1
Leg predicted mass (right)	0.0	0.1	0.4	0.6	-0.6	-0.1	0.1	0.0
Basal metabolic rate	0.0	0.2	1.0	0.3	-1.0	-0.5	0.2	0.3
Impedance of whole body	0.0	0.2	0.8	-0.6	0.2	-0.5	0.1	0.9

Hub : Genes

IL27RA

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Trait associations