Hub : Genes

ILVBL

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1220	0.0340	6.8e-05	0.051	0.046	0.043	0.054	0.050	6.7e-07	2.4e-06	5.2e-06	3.2e-07	9.7e-07
2	YFS	Blood	0.0657	0.0150	5.0e-10	0.053	0.028	0.050	0.050	0.046	7.4e-17	9.6e-10	7.0e-16	4.9e-16	5.8e-15
3	TCGA	Prostate Adenocarcinoma	0.0662	0.0344	6.5e-03	0.003	0.005	0.001	NA	0.002	1.4e-01	9.6e-02	2.4e-01	NA	1.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.3	0.6	0.2	0.8	-0.3
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	0.2	0.8	0.2
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	0.7	0.2	0.2
Depression (Nagel 2018)	0.0	0.0	0.1	0.1	-0.3	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	-1.0	-0.4	-0.0
Neuroticism (Nagel 2018)	0.3	0.6	1.2	0.5	0.6	-1.1
Schizophrenia (2018)	0.1	0.1	0.3	0.1	0.4	0.5
Schizophrenia vs Biploar Disorder	0.9	1.2	2.7	0.2	-1.0	1.6
Worry (Nagel 2018)	2.0	4.3	9.0	-1.1	1.6	-3.0
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.4	-0.0	-0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.1	0.4	-0.5
Alzheimer’s Disease (including proxy)	0.5	0.8	1.4	-0.2	0.9	-1.2
Crohns Disease (2017)	0.6	1.4	2.4	1.5	0.8	-1.0
Irritable Bowel Disease (IBD)	0.9	2.2	5.3	2.3	1.0	-0.6
Ulcerative Colitis (UC)	0.5	1.0	2.8	1.7	0.5	-0.1
Major Depression (MDD)	0.8	0.9	2.2	0.1	-1.5	-0.8
Reaction Time	0.3	0.6	1.7	1.3	-0.2	-0.3
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.7	-0.5	1.7	-0.1
Breast Cancer	0.4	1.0	1.5	0.2	-1.2	1.2
Ovarian Cancer	0.3	0.4	0.9	0.9	-0.1	0.5
Prostate Cancer	0.4	0.5	0.7	-0.5	0.9	-0.7
Age at First Birth	0.2	0.3	0.5	0.7	0.1	0.7
Bipolar Disorder (2011)	0.3	0.3	0.8	0.9	0.2	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.4	0.1	-0.9	1.2
Coronary Artery Disease (CAD)	2.0	2.4	7.0	-2.6	-0.4	-0.1
Crohns Disease (2012)	0.3	0.5	1.1	0.3	1.1	-0.6
Mean Putamen Volume	0.4	0.4	0.8	-0.9	-0.7	0.1
Fasting Glucose	0.3	0.3	0.9	-0.2	0.1	1.0
HbA1C	1.2	1.3	3.3	-0.3	0.8	-1.8
HDL Cholesterol	0.4	0.6	1.8	0.3	-0.3	1.3
LDL Cholesterol	0.1	0.1	0.3	0.2	-0.2	0.5
Lupus	1.3	1.9	4.4	2.1	1.0	0.6
Neuroticism (2016)	0.2	0.3	0.5	0.7	0.4	-0.6
Primary Biliary Cirrhosis	0.3	0.4	1.0	0.4	0.3	-1.0
Rheumatoid Arthritis	0.1	0.1	0.2	-0.2	-0.4	-0.1
Schizophrenia (2014)	0.3	0.7	1.0	1.0	0.6	0.9
Triglycerides	1.0	1.7	3.7	-1.9	0.8	-0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.8	-0.9	-0.7	-0.1
Ulcerative Colitis	0.6	0.9	1.9	1.4	0.2	0.8
Blood Eosinophil Count	0.2	1.6	3.1	0.1	-1.8	1.3
Blood Platelet Count	0.0	0.4	1.2	1.1	0.1	-0.2
Blood Red Count	1.3	12.6	26.6	0.4	-3.3	5.2
Blood White Count	0.1	0.6	1.4	1.2	-0.6	0.4
Heel T-Score	0.2	1.8	4.2	-2.1	0.9	-0.7
BMI	0.4	2.4	4.5	1.0	-2.1	1.3
Height	0.2	4.3	10.4	3.2	1.1	-1.1
Waist Hip Ratio (WHR)	0.6	2.8	7.4	-0.5	-0.9	2.7
Systolic Blood Pressure	0.9	4.3	12.2	-3.5	-0.6	-0.6
Smoking Status	0.0	0.1	0.1	-0.2	0.1	-0.3
Allergy or Eczema	0.6	1.6	4.9	2.2	-0.0	0.2
Cardiovascular Disease	0.4	1.2	2.6	-1.6	-0.3	0.9
Hypothyroidism (self reported)	0.6	1.5	2.4	-1.1	-1.5	0.9
Respiratory disease	1.1	2.5	3.2	1.4	-1.8	1.6
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.5	-0.7	-0.5	-0.3
Lung FEV1/FVC ratio	0.5	2.3	5.3	-2.3	-0.8	-0.9
Lung FVC	0.4	2.2	4.3	-1.3	2.1	-0.8
Neuroticism	1.0	2.4	3.9	1.1	1.5	-2.0
Chronotype (morning person)	0.0	0.0	0.1	0.0	0.3	0.1
Hair Pigment	0.0	0.7	1.4	1.2	-0.1	0.9
Tanning	0.0	0.0	0.0	-0.0	0.1	-0.0
Hand grip strength (left)	0.0	0.1	0.3	0.3	-0.5	-0.2
Number of treatments/medications taken	0.1	0.2	0.4	-0.6	-0.5	0.1
Average weekly spirits intake	0.4	0.5	1.4	0.1	1.2	-0.3
Sensitivity / hurt feelings	0.7	1.3	3.2	1.8	0.7	-0.2
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.6	-0.6	0.6	-0.8
Hearing difficulty/problems: Yes	0.5	0.8	1.8	0.6	-1.3	0.3
Relative age of first facial hair	0.2	0.4	0.5	-0.6	-0.7	0.5
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	3.2	1.8	-0.2	-0.4
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.6	0.1	1.1	-1.3
Ever had hysterectomy (womb removed)	2.4	2.7	6.1	-2.5	0.9	-1.1
Systolic blood pressure, automated reading	0.6	1.8	3.9	-2.0	-1.2	-0.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.7	0.9	0.2	-0.7
Angina	0.6	0.8	1.6	0.6	-0.5	-1.3
Medication for hormone replacement therapy	0.8	0.9	2.3	1.5	0.4	-0.7
Vitamin and mineral supplements	1.1	1.5	2.7	-1.6	-1.3	0.2
Supplements: Zinc	0.4	0.4	0.8	0.3	0.9	-0.7
Medication: Co-codamol	0.1	0.2	0.2	0.5	-0.4	0.2
Medication: Metformin	0.1	0.2	0.5	-0.7	-0.0	0.3
Diabetes (father)	1.2	1.5	2.6	1.6	1.0	-1.0
Diabetes (mother)	0.1	0.2	0.4	0.6	-0.1	0.3
Severe depression (siblings)	0.5	0.5	1.1	-0.5	0.5	-1.1
Pack years adult smoking proportion	1.4	2.1	4.2	-0.6	-1.3	2.0
Impedance of leg (right)	0.3	1.6	1.9	-1.2	1.4	-1.2
Leg fat-free mass (left)	0.3	1.3	2.1	1.3	-0.4	1.4
Trunk fat percentage	0.2	0.9	1.4	0.7	-1.2	0.9
Hand grip strength (right)	0.2	0.6	1.0	0.7	-1.0	0.4
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.0	0.2	-0.5
Current tobacco smoking	0.5	0.8	0.9	0.8	-0.9	1.0
Average weekly fortified wine intake	2.1	2.5	6.7	2.6	-0.7	0.5
Maternal smoking around birth	0.3	0.4	0.6	-0.7	-0.8	-0.3
Fed-up feelings	0.5	0.8	1.6	-0.4	1.3	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	-0.2	0.1	-0.3
Relative age voice broke	0.0	0.1	0.2	-0.0	0.2	0.4
Taking other prescription medications	0.1	0.2	0.6	0.2	-0.8	0.0
Age when periods started (menarche)	1.0	2.3	4.9	-2.2	-0.1	1.4
Bilateral oophorectomy (both ovaries removed)	2.8	3.2	5.9	-1.4	1.3	-2.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.2	0.2	-0.5	0.4
Tinnitus: Yes, but not now, but have in the past	3.8	4.0	4.6	1.8	-2.0	2.1
Qualifications: CSEs or equivalent	0.7	1.0	2.4	-0.7	1.6	-0.0
Serious illness, injury or assault to yourself	0.3	0.4	1.1	-1.0	0.1	-0.4
High blood pressure	1.0	2.7	3.4	-1.7	-1.8	1.4
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.2	1.8	0.5	0.6
Multivitamins +/- minerals	1.2	1.6	2.4	1.5	1.0	-1.2
Stomach or abdominal pain in last month	0.7	0.8	1.2	0.7	-0.9	1.1
Supplements: Glucosamine	1.8	2.4	3.6	0.6	-1.8	1.9
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.5	1.2	0.9	-0.3
Medication: Atenolol	0.2	0.3	0.6	-0.8	-0.5	0.2
Medication: Levothyroxine sodium	0.3	0.6	1.2	-1.1	0.6	-0.2
Sitting height	0.1	0.8	1.8	0.2	1.3	-0.8
Chronic bronchitis/emphysema (father)	1.4	1.7	3.0	-1.3	-0.6	1.7
High blood pressure (mother)	0.6	0.8	1.8	-0.1	1.4	-0.8
Body mass index (BMI)	0.5	1.9	2.9	0.6	-1.7	1.6
Impedance of leg (left)	0.3	1.5	1.9	-1.1	1.4	-1.2
Leg predicted mass (left)	0.3	1.3	2.1	1.4	-0.3	1.5
Trunk fat mass	0.3	1.2	1.6	0.9	-1.3	1.0
Waist circumference	0.6	2.3	5.2	0.4	-1.2	2.3
Number of incorrect matches in round	0.6	0.9	2.2	-1.5	-0.5	0.6
Past tobacco smoking	0.2	0.3	0.5	-0.7	-0.6	0.1
Alcohol usually taken with meals	1.9	3.0	6.8	2.6	1.1	-1.0
Nervous feelings	0.5	1.0	2.4	0.2	0.7	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.9	3.0	5.0	-0.0	2.0	-2.2
Hearing difficulty/problems with background noise	1.3	2.1	3.0	1.7	-1.7	0.7
Hair/balding pattern: Pattern 2	6.3	8.1	14.8	0.0	3.8	-3.1
Had menopause	0.1	0.1	0.2	-0.3	0.5	0.1
Had other major operations	1.6	1.9	5.8	2.4	-0.3	0.0
Forced vital capacity (FVC)	0.5	1.8	5.4	-0.0	2.3	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.6	0.6	-1.2	1.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.3	-0.9	-0.3	1.2
Qualifications: None of the above	1.6	3.4	5.6	-1.7	-2.4	1.4
Financial difficulties in last 2 years	0.5	0.7	1.4	1.2	0.7	0.0
Mouth/teeth dental problems	1.4	2.1	2.4	-1.4	1.4	-1.5
Heart attack	0.9	1.1	1.4	0.8	1.2	-1.1
Allergy	0.6	1.4	3.2	-1.8	0.4	-1.0
Pain all over the body in last month	0.0	0.0	0.1	-0.2	0.0	-0.3
Diabetes (self-reported)	0.2	0.2	0.6	-0.8	0.2	-0.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	2.1	1.4	0.1	0.3
Medication: Ramipril	0.2	0.3	0.8	-0.0	0.3	-0.9
Medication: Simvastatin	0.3	0.4	1.1	-0.3	-0.1	-1.1
Fluid intelligence score	0.8	1.8	4.8	0.5	2.2	-0.5
Illnesses of siblings	0.2	0.3	0.8	-0.2	0.9	0.3
Neuroticism score	1.4	3.0	5.6	0.3	1.8	-2.4
Weight	0.4	1.7	2.0	1.3	-1.2	1.4
Impedance of arm (right)	0.2	1.0	1.7	0.6	0.9	-1.3
Arm fat percentage (right)	0.5	1.9	2.8	1.2	-1.7	1.2
Trunk fat-free mass	0.1	0.7	1.2	1.0	0.0	1.1
Hip circumference	0.3	1.3	2.5	1.6	-0.9	0.8
Time employed in main current job	1.5	1.7	4.1	1.0	-0.3	-2.0
Alcohol intake versus 10 years previously	1.4	2.1	2.7	-1.6	-1.6	0.9
Father’s age at death	1.6	2.2	2.8	1.5	-1.2	1.7
Worrier / anxious feelings	1.5	2.9	5.8	0.8	1.5	-2.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.2	-0.3	0.4
Falls in the last year	1.6	2.1	5.6	2.4	0.9	0.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.2	0.4	-0.5	0.3
Number of live births	0.4	0.6	1.2	0.0	0.8	1.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	7.3	-0.3	2.7	-0.8
Pulse rate	0.5	0.8	2.2	-1.5	-0.4	0.4
Happiness	0.4	0.5	0.7	-0.8	0.3	-0.9
Noisy workplace	1.7	2.0	2.8	-1.7	-1.6	0.9
Qualifications: A levels/AS levels or equivalent	0.9	1.9	5.4	2.3	-0.3	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.6	0.8	1.6	-1.0
Mouth/teeth dental problems: Dentures	0.7	1.1	3.0	-1.7	-0.4	-0.5
Asthma	1.2	2.3	3.3	0.9	-1.7	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.0	-1.4	-0.3	0.8
Medication: Cholesterol lowering	0.5	0.7	1.2	1.1	-1.0	-0.2
Depression (self-reported)	3.3	4.0	10.3	3.2	-1.2	0.6
Medication: Lansoprazole	0.4	0.4	0.7	0.8	0.1	0.8
Prospective memory result	1.6	2.0	3.7	1.5	-1.9	-0.3
Lung cancer (father)	0.5	0.5	1.5	-1.2	-0.2	-0.3
Illnesses of mother	0.4	0.5	1.4	1.2	0.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	5.1	-0.8	2.3	-1.1
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	-0.4	-0.5	0.4
Impedance of arm (left)	0.1	0.5	0.9	0.4	0.7	-1.0
Arm fat mass (right)	0.4	1.7	1.9	1.1	-1.3	1.4
Trunk predicted mass	0.1	0.7	1.1	1.0	0.0	1.1
Standing height	0.1	1.2	2.5	1.6	1.1	-0.1
Length of working week for main job	0.1	0.1	0.2	-0.3	-0.4	-0.3
Exposure to tobacco smoke at home	0.8	0.9	2.0	-0.1	-0.9	1.4
Breastfed as a baby	1.6	2.0	5.1	2.2	-0.9	0.5
Tense / ‘highly strung’	1.1	1.9	3.6	-0.7	1.3	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.1	0.9	-0.3	1.1
Hair/balding pattern: Pattern 4	0.9	2.1	3.5	1.6	-1.9	0.4
Birth weight of first child	0.2	0.4	0.6	-0.7	0.8	-0.4
Peak expiratory flow (PEF)	0.5	1.1	2.4	-0.9	1.5	-0.3
Pulse wave reflection index	0.3	0.3	0.9	-0.9	-0.1	0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	0.2	-0.1	0.2
Loud music exposure frequency	0.9	1.0	1.5	1.2	-1.0	0.7
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	1.9	1.3	1.4	-0.7
Mouth/teeth dental problems: Bleeding gums	4.0	5.2	9.0	2.3	-1.2	3.0
Blood clot in the leg (DVT)	0.5	0.6	0.8	0.8	-0.7	0.9
Medication: Paracetamol	0.8	1.3	2.0	-1.1	0.8	-1.4
Headache pain in last month	0.3	0.5	1.0	1.0	-0.4	0.6
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	1.9	0.4	1.4	-1.3
Glaucoma (self-reported)	2.0	2.3	3.6	0.0	-1.9	1.8
Gout (self-reported)	2.0	2.7	6.7	-0.2	2.6	-1.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	0.9	-0.9	-0.7	0.1
Medication: Amlodipine	0.8	1.2	2.4	-0.9	-1.5	0.6
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.1	1.4	-0.5	0.8
Birth weight	0.6	1.3	2.9	-1.7	0.2	-1.1
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.3	1.8	-1.2	0.4
High blood pressure (siblings)	0.6	0.8	1.3	1.1	-1.1	0.2
Forced vital capacity (FVC), Best measure	0.4	1.5	4.0	-0.4	2.0	-0.5
Body fat percentage	0.2	0.9	1.7	0.4	-1.3	0.9
Leg fat percentage (right)	0.2	0.6	1.1	-0.1	-1.0	0.8
Arm fat-free mass (right)	0.1	0.6	1.6	0.4	-0.1	1.3
Exposure to tobacco smoke outside home	1.1	1.5	2.9	-0.3	-1.7	1.2
Comparative body size at age 10	0.2	0.6	1.5	1.2	0.2	-0.6
Number of full brothers	0.5	0.6	1.5	-0.3	0.4	-1.2
Worry too long after embarrassment	0.3	0.5	1.4	1.2	0.1	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.0	1.4	-0.0	0.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	-0.1	-0.8	0.2
Number of children fathered	0.9	1.0	2.6	-0.4	-1.6	0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	3.1	-0.8	0.1	-1.8
Age at first live birth	0.3	0.5	1.0	1.0	-0.6	0.4
Pulse wave peak to peak time	0.2	0.3	0.3	0.5	0.6	-0.6
Health satisfaction	1.1	1.4	3.3	0.1	-1.8	0.9
Shortness of breath walking on level ground	0.5	0.5	1.1	0.7	-1.0	0.3
Qualifications: College or University degree	0.3	0.9	1.8	1.3	0.7	-0.6
Eye problems/disorders: None of the above	1.5	1.7	3.9	-0.0	2.0	-1.2
Mouth/teeth dental problems: Loose teeth	2.2	2.6	5.2	2.3	-1.4	0.9
Emphysema/chronic bronchitis	0.7	0.8	1.3	1.0	-1.1	-0.5
Medication for pain relief, constipation, heartburn	2.9	4.9	7.2	2.0	-1.9	2.7
Neck or shoulder pain in last month	1.4	2.0	2.5	1.6	-1.1	1.4
Medication: Blood pressure	2.1	3.8	5.3	-1.0	-2.3	2.2
Angina (self-reported)	0.6	0.7	1.0	0.7	-0.8	-1.0
Migraine (self-reported)	0.8	1.0	2.9	1.7	0.4	0.2
Medication: Ibuprofen	0.8	1.0	1.8	-1.4	-0.5	0.9
Medication: Allopurinol	1.0	1.3	2.3	-0.6	1.5	-1.1
Medication: Omeprazole	0.8	1.0	2.3	0.1	1.5	-0.8
Medication: Seretide 50 evohaler	0.1	0.2	0.3	0.4	-0.5	-0.2
Mean time to correctly identify matches	0.6	1.2	2.0	1.4	-1.2	0.3
Heart disease (mother)	1.1	1.3	2.6	-1.6	1.0	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	2.9	-0.7	-1.7	1.7
Whole body fat mass	0.3	1.4	1.9	0.9	-1.4	1.3
Leg fat mass (right)	0.3	1.2	1.7	0.7	-1.2	1.3
Arm predicted mass (right)	0.1	0.6	1.5	0.5	0.2	1.2
Pulse rate, automated reading	0.4	1.3	3.7	-1.9	-0.6	0.0
Alcohol intake frequency.	0.8	1.8	4.5	-2.1	-1.0	0.2
Comparative height size at age 10	0.0	0.2	0.4	0.2	0.6	-0.4
Number of full sisters	0.2	0.3	0.5	-0.4	-0.3	0.7
Suffer from ‘nerves’	1.9	2.9	4.4	-1.4	1.6	-2.1
Overall health rating	0.0	0.1	0.1	-0.3	-0.2	0.2
Chest pain or discomfort	0.3	0.5	1.3	1.1	-0.2	0.1
Had major operations	1.7	2.0	3.3	0.6	-1.8	1.5
Age at last live birth	0.3	0.4	1.2	1.1	-0.2	0.4
Family relationship satisfaction	0.8	1.0	1.6	1.3	-0.8	0.9
Leg pain on walking	2.0	2.5	5.1	0.4	-1.5	2.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.8	0.9	0.1	0.0
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.4	0.4	-1.6	1.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.9	-0.8	-1.4	0.4
Medication: Aspirin	0.1	0.2	0.3	0.0	-0.4	-0.6
Supplements: Vitamin C	0.3	0.3	0.7	0.5	-0.1	0.8
Knee pain experienced in last month	0.4	0.6	1.2	1.1	0.3	0.7
Hypertension (Self-reported)	1.1	3.1	4.8	-2.2	-1.6	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.1	0.5	-1.0	0.1
Illnesses of father: Heart disease	0.2	0.3	0.5	0.3	-0.7	-0.5
Illnesses of siblings: Diabetes	0.3	0.3	0.7	-0.4	0.2	0.9
Smoking status: Previous	0.3	0.4	0.7	0.1	0.8	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.2	0.8	1.1	-0.4
Whole body fat-free mass	0.2	1.0	1.4	1.2	-0.1	1.2
Leg fat-free mass (right)	0.3	1.5	2.3	1.5	-0.3	1.4
Arm fat percentage (left)	0.4	1.6	2.6	0.9	-1.6	1.2
Average weekly red wine intake	2.4	3.6	7.2	2.7	1.8	-0.7
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.2	0.3	-0.4	-0.4
Mood swings	1.1	2.0	2.7	-1.1	1.6	-1.5
Loneliness, isolation	0.5	0.7	1.4	1.2	0.2	0.8
Long-standing illness, disability or infirmity	0.1	0.2	0.5	-0.1	-0.7	0.2
Ever had bowel cancer screening	0.7	0.8	1.0	-1.0	-0.9	-0.8
Diabetes diagnosed by doctor	0.2	0.3	0.8	-0.9	-0.0	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.2	-1.1	0.6	-1.0
Friendships satisfaction	0.4	0.4	1.0	-1.0	-0.5	-0.1
Qualifications: nursing, teaching	1.0	1.5	3.4	1.9	1.0	0.4
Commuting to job workplace: Walk	0.5	0.5	1.1	-0.6	0.3	-1.0
Eye problems/disorders: Cataract	0.4	0.5	0.8	-0.8	-0.1	0.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.6	0.4	1.9	-0.4
Medication for cholesterol	0.3	0.4	0.6	0.2	-0.8	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.7	0.4	0.7	-1.3
Back pain experienced in last month	0.7	1.0	1.5	-1.2	1.2	0.2
Mineral and other dietary supplements	1.7	2.3	2.8	-1.5	1.7	-1.4
Breast cancer (self-reported)	0.4	0.4	0.8	-0.7	0.1	-0.9
Asthma (self-reported)	1.3	2.6	3.8	1.0	-1.7	2.0
Osteoporosis (self-reported)	0.4	0.6	0.8	-0.9	-0.3	0.9
Osteoarthritis (self-reported)	0.4	0.5	0.7	-0.7	-0.8	0.6
Medication: Aspirin	0.3	0.4	0.7	-0.5	-0.8	-0.4
Medication: Gliclazide	1.2	1.4	1.9	-1.2	-1.4	0.9
Illnesses of father: None of the above (group 1)	1.1	1.4	2.7	-0.1	1.2	-1.7
Smoking status: Current	0.7	1.2	1.3	1.0	-1.1	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.1	-0.7	1.1	-0.6
Whole body water mass	0.2	1.1	1.6	1.3	-0.1	1.3
Leg predicted mass (right)	0.3	1.4	2.1	1.4	-0.3	1.4
Arm fat mass (left)	0.4	1.4	1.9	1.0	-1.2	1.4
Number of self-reported non-cancer illnesses	1.0	1.8	2.3	1.1	-1.3	1.5
Average weekly champagne plus white wine intake	0.6	0.9	1.6	-0.3	1.0	-1.2
Miserableness	1.2	2.1	3.8	-0.7	1.9	-1.4
Guilty feelings	1.1	1.6	2.1	-1.1	1.5	-1.3
Wears glasses or contact lenses	0.0	0.0	0.1	-0.1	-0.2	0.3
Ever taken oral contraceptive pill	0.2	0.2	0.5	0.3	0.7	-0.3
Hearing aid user	0.3	0.4	0.8	0.9	-0.1	0.6
Mother’s age at death	0.2	0.3	0.6	0.2	-0.8	0.5
Financial situation satisfaction	0.2	0.2	0.5	0.2	-0.1	0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	-1.0	-0.1	1.1
Commuting to job workplace: Public transport	1.1	1.3	1.9	-0.3	1.4	-1.4
Eye problems/disorders: Glaucoma	2.2	2.7	4.3	-0.8	-2.1	1.8
Medication: Blood pressure	0.4	0.7	1.5	-1.2	0.5	-0.6
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.4	-0.6	-0.3	0.3
Supplements: Fish oil (including cod liver oil)	0.9	1.2	3.3	1.8	-0.0	-0.4
High cholesterol (Self-reported)	0.3	0.5	0.7	-0.5	0.7	-0.8
Medication: Bendroflumethiazide	0.8	1.2	3.6	-1.9	0.1	0.1
Medication: Paracetamol	0.8	1.3	2.4	-0.9	0.8	-1.6
Medication: Lisinopril	0.6	0.8	1.7	-1.3	0.7	0.5
Medication: Atorvastatin	0.6	0.7	1.0	1.0	-0.9	0.6
Illnesses of father: High blood pressure	0.5	0.6	1.0	1.0	0.4	0.8
Alcohol drinker status: Never	0.4	0.5	1.0	-0.3	1.0	-0.6
Ever smoked	1.0	1.7	4.7	2.2	0.6	0.2
Basal metabolic rate	0.2	1.1	1.8	1.2	-0.4	1.4
Leg fat percentage (left)	0.2	0.7	1.3	-0.2	-1.1	0.8
Arm fat-free mass (left)	0.1	0.7	1.4	0.8	0.0	1.2
Number of operations (self-reported)	0.1	0.1	0.2	0.1	-0.5	0.1
Average weekly beer plus cider intake	0.2	0.3	0.7	-0.8	0.4	-0.4
Irritability	0.5	0.9	1.4	1.1	0.3	-1.2
Risk taking	0.4	0.6	0.8	-0.4	-0.8	0.9
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.2	1.0	-1.1	1.5
Fractured/broken bones in last 5 years	1.4	1.7	2.8	-1.2	1.7	-1.1
Age started oral contraceptive pill	0.7	0.9	2.1	-1.5	0.2	-0.6
Diastolic blood pressure, automated reading	0.1	0.4	0.6	-0.7	-0.2	0.7
Ever depressed for a whole week	0.6	0.7	1.8	1.3	0.5	0.3
Unable to work because of sickness or disability	0.3	0.4	0.9	1.0	0.2	-0.4
Commuting to job workplace: Cycle	0.2	0.2	0.6	-0.8	0.1	0.2
Myopia	2.3	3.3	9.7	3.1	0.1	0.5
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.8	1.7	0.9	-0.8
Cholesterol lowering medication	1.1	1.6	2.5	-1.1	1.0	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	0.4	0.7	-0.2
Pain experienced in last month	0.1	0.2	0.3	0.3	-0.3	-0.6
Supplements: Calcium	0.1	0.1	0.4	0.6	0.0	-0.2
Basal cell carcinoma (self-reported)	1.8	2.1	5.6	2.4	-0.7	0.6
Heart attack/myocardial infarction (self-reported)	0.5	0.6	0.7	0.8	0.8	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	1.7	1.0	-1.0	1.3
Heart disease (siblings)	0.2	0.3	0.8	-0.9	-0.2	-0.1
Alcohol drinker status: Previous	0.2	0.2	0.7	0.2	-0.8	0.2
Pack years of smoking	1.2	1.7	3.4	-0.5	-1.2	1.9
Impedance of whole body	0.1	0.8	1.2	-0.3	1.0	-1.1
Leg fat mass (left)	0.3	1.1	1.6	0.7	-1.2	1.3
Arm predicted mass (left)	0.1	0.7	1.3	0.9	-0.2	1.1