Hub : Genes

INO80C

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.2590	0.0840	2.0e-03	0.218	NA	0.126	NA	0.182	2.7e-06	NA	4.0e-04	NA	2.0e-05
2	GTEx	Brain Cerebellum	0.2580	0.0890	2.5e-03	0.059	NA	0.133	NA	0.129	8.1e-03	NA	9.9e-05	NA	1.2e-04
3	GTEx	Pituitary	0.3240	0.0990	2.9e-03	-0.010	NA	-0.011	NA	-0.011	7.0e-01	NA	8.3e-01	NA	7.5e-01
4	GTEx	Testis	0.2140	0.0730	1.3e-03	0.139	NA	0.166	NA	0.186	1.0e-06	NA	7.9e-08	NA	1.2e-08
5	METSIM	Adipose	0.0471	0.0188	1.0e-03	0.012	0.013	0.004	0.012	0.009	5.7e-03	3.6e-03	8.5e-02	4.8e-03	1.4e-02
6	YFS	Blood	0.0696	0.0228	5.7e-10	0.027	0.034	0.050	0.036	0.044	2.8e-09	2.5e-11	4.6e-16	5.8e-12	2.2e-14
7	TCGA	Thyroid Carcinoma	0.0730	0.0300	6.5e-05	0.008	0.020	0.013	NA	0.008	5.0e-02	4.2e-03	1.9e-02	NA	5.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.1	0.1	0.4	0.3	-0.3	0.5	0.7	-0.0	0.1	0.2
Bipolar Disorder or Schizophrenia	0.2	0.5	2.4	-0.3	-0.3	-0.1	0.4	0.6	1.6	-0.4
Depressed Affect (Nagel 2018)	0.1	0.2	1.1	-0.5	0.2	0.6	-0.1	-1.0	-0.2	-0.1
Depression (Nagel 2018)	0.2	0.3	1.4	-0.5	0.1	0.2	0.2	-1.2	0.8	-0.4
Intelligence (Savage-Jansen 2018)	0.7	2.2	5.6	1.4	2.1	-0.6	1.3	-0.6	0.7	-2.4
Neuroticism (Nagel 2018)	0.1	0.1	0.4	-0.6	-0.1	0.4	-0.1	-0.5	0.2	0.2
Schizophrenia (2018)	0.4	0.8	3.8	-0.7	-0.2	-0.6	-0.1	0.9	1.9	-0.7
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	-0.2	0.1	-0.4	-0.6	-0.3	0.0	-0.5
Worry (Nagel 2018)	0.1	0.3	1.0	-0.4	0.4	-0.5	0.0	1.0	0.7	-0.3
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	-0.1	0.2	-0.5	-0.2	-0.5	-0.4	-0.9
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.4	-0.1	-0.6	-0.5	-0.5	0.3	0.2
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	-0.0	0.4	-0.3	-0.2	-0.5	-0.4	-0.6
Crohns Disease (2017)	0.6	1.4	3.6	0.2	0.9	-1.9	0.4	-0.3	1.5	-1.6
Irritable Bowel Disease (IBD)	0.8	1.8	4.0	0.8	1.0	-1.2	0.3	-2.0	1.2	-2.0
Ulcerative Colitis (UC)	0.8	1.5	5.0	1.1	0.9	-0.1	0.7	-2.2	0.9	-1.5
Major Depression (MDD)	1.1	1.3	3.8	-1.0	-0.6	-1.8	-0.4	0.5	1.9	-0.1
Reaction Time	0.8	1.5	5.5	-0.9	-0.3	-1.3	-0.1	1.6	2.3	-0.0
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.0	1.4	0.9	0.3	1.0	0.4	-0.6	-0.8
Breast Cancer	0.4	1.1	4.6	-0.1	0.5	-0.7	0.5	1.3	2.1	0.3
Ovarian Cancer	0.1	0.1	0.5	-0.3	0.2	-0.7	-0.0	0.4	-0.1	-0.3
Prostate Cancer	0.3	0.5	1.4	-0.4	-1.0	0.5	0.3	0.2	-0.8	1.2
Age at First Birth	0.5	0.7	2.1	-0.7	-0.3	-0.4	-0.5	0.2	-1.5	1.3
Bipolar Disorder (2011)	1.1	1.0	2.7	1.1	1.6	0.4	1.6	0.9	-0.2	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	0.1	0.0	0.5	0.9	-0.2	0.9	-0.5
Coronary Artery Disease (CAD)	1.6	1.9	3.3	1.8	1.7	-0.8	1.3	-1.1	0.5	-1.8
Crohns Disease (2012)	0.5	0.7	2.9	-0.6	-0.0	-1.7	-0.5	0.7	1.0	-0.2
Mean Putamen Volume	0.5	0.6	2.0	-0.5	-0.8	0.3	-0.6	-0.3	-0.8	1.4
Fasting Glucose	2.2	2.6	7.3	-1.3	-2.0	0.8	-1.3	1.7	-0.3	2.7
HbA1C	0.5	0.5	2.8	-0.3	-0.6	-0.5	-0.2	0.2	1.7	-0.4
HDL Cholesterol	0.8	1.3	2.6	1.4	1.1	1.6	0.5	-0.9	-1.5	-0.2
LDL Cholesterol	1.0	1.5	3.5	-1.2	-1.7	0.6	-1.2	0.5	-0.9	1.9
Lupus	1.8	2.8	8.0	0.9	1.5	-1.8	1.1	-0.7	2.8	-1.9
Neuroticism (2016)	0.4	0.5	1.7	-0.8	-0.2	0.5	-0.7	0.7	0.4	1.3
Primary Biliary Cirrhosis	1.1	1.6	5.3	-0.6	0.9	-1.5	-0.3	1.2	2.3	-1.0
Rheumatoid Arthritis	0.3	0.4	2.5	0.4	-0.0	-0.4	-0.3	1.6	0.0	-0.3
Schizophrenia (2014)	0.3	0.7	2.7	-0.3	0.0	-0.5	0.2	0.2	1.6	-1.5
Triglycerides	0.3	0.5	2.3	0.2	-0.1	-1.5	-0.0	-0.6	1.0	0.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.1	1.1	0.4	0.9	1.5	0.3	0.6	0.1
Ulcerative Colitis	0.9	1.4	2.2	1.2	1.2	-0.5	0.4	-1.5	1.3	-1.5
Blood Eosinophil Count	0.4	3.4	14.8	-1.3	-0.7	-1.1	-0.6	3.9	2.1	0.9
Blood Platelet Count	0.6	6.9	14.3	2.0	3.2	-2.2	1.7	-1.7	3.1	-3.8
Blood Red Count	0.2	1.5	5.6	1.0	0.7	-2.4	-0.4	-1.3	-0.1	-1.2
Blood White Count	0.4	2.9	11.9	-0.6	-1.1	-1.4	-1.8	-3.4	1.3	0.2
Heel T-Score	1.6	12.7	43.4	2.3	3.3	-4.2	1.2	-3.2	0.5	-6.6
BMI	0.4	2.4	8.1	-0.9	-0.6	-0.5	-1.7	1.5	2.8	1.6
Height	1.3	25.6	63.7	-3.4	-4.8	4.0	-4.8	4.2	-5.0	8.0
Waist Hip Ratio (WHR)	0.7	3.1	7.2	-1.9	-2.1	-1.0	-2.7	1.3	0.1	1.9
Systolic Blood Pressure	0.4	2.1	4.5	1.7	1.7	-1.0	1.7	0.6	-0.1	-2.1
Smoking Status	0.5	1.2	2.7	-1.2	-1.0	-1.6	-1.3	0.6	-0.6	0.8
Allergy or Eczema	0.3	0.7	2.1	-0.4	-0.5	0.9	-0.8	0.9	-1.5	0.6
Cardiovascular Disease	0.5	1.5	2.9	-1.6	-1.5	-1.0	-1.7	1.1	0.2	0.7
Hypothyroidism (self reported)	0.3	0.6	1.3	1.1	0.4	0.6	1.1	0.4	-1.0	-0.1
Respiratory disease	1.2	2.6	13.1	-0.3	-0.1	1.7	0.1	3.6	0.1	1.4
Type 2 Diabetes (T2D) (2018)	0.7	1.2	6.1	-0.6	-0.2	-2.5	-0.7	0.6	0.9	-0.7
Lung FEV1/FVC ratio	0.3	1.6	3.3	1.1	1.7	-1.2	1.1	-0.8	0.6	-1.8
Lung FVC	1.7	8.5	20.5	2.8	4.2	-0.5	2.7	-1.2	2.0	-4.5
Neuroticism	0.3	0.6	1.1	0.3	1.1	0.6	0.8	0.5	0.9	-1.0
Chronotype (morning person)	0.3	0.8	1.8	-0.1	-0.2	1.3	-0.8	-0.5	-1.2	1.2
Hair Pigment	0.0	0.6	1.6	0.3	0.0	-0.6	0.2	1.3	-1.2	-0.6
Tanning	0.0	0.4	1.4	0.2	0.0	1.2	-0.9	-0.5	-0.6	0.5
Hand grip strength (left)	0.2	0.5	1.6	0.8	0.8	-0.3	-0.1	-1.3	-0.1	0.6
Number of treatments/medications taken	1.7	3.1	6.4	-2.1	-1.8	-1.6	-0.9	2.5	1.7	1.3
Average weekly spirits intake	1.1	1.4	2.6	1.1	1.6	0.4	1.4	0.9	1.1	-1.3
Sensitivity / hurt feelings	0.2	0.4	1.0	0.1	-0.5	1.0	0.9	-0.5	0.4	0.8
Frequency of depressed mood in last 2 weeks	1.1	1.5	4.6	-2.1	-1.2	-0.6	-1.1	-0.1	1.8	-0.1
Hearing difficulty/problems: Yes	0.2	0.3	0.7	-0.1	0.1	0.0	0.6	0.7	0.8	0.8
Relative age of first facial hair	0.2	0.4	2.5	-0.0	-0.5	0.2	-0.2	0.2	-1.6	0.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.5	-0.7	-0.8	0.7	0.1	1.0	1.2	1.1
Ever used hormone-replacement therapy (HRT)	0.8	1.0	5.5	-0.2	-0.4	0.2	0.7	2.3	0.8	0.6
Ever had hysterectomy (womb removed)	2.5	2.9	9.5	-0.8	-0.6	-2.3	-0.9	1.8	3.1	-0.5
Systolic blood pressure, automated reading	1.1	3.2	6.6	1.9	2.2	-1.6	2.0	0.2	0.8	-2.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.4	-1.5	-0.8	-0.7	-1.5	0.6	0.5	0.2
Angina	0.4	0.5	1.0	-0.9	-0.3	0.6	-0.5	0.9	0.5	1.0
Medication for hormone replacement therapy	0.7	0.8	1.9	-0.4	-1.4	1.2	-0.4	-0.7	-1.3	0.3
Vitamin and mineral supplements	2.1	2.8	4.4	2.1	1.7	-1.4	1.7	-1.2	1.4	-2.0
Supplements: Zinc	1.8	2.0	5.7	-2.4	-1.4	-0.6	-1.0	1.2	1.3	1.4
Medication: Co-codamol	0.2	0.3	1.0	-0.6	-0.5	-0.1	-0.2	1.0	-0.1	0.5
Medication: Metformin	0.9	1.3	6.8	-0.1	0.2	-2.6	-0.4	0.6	0.4	-1.1
Diabetes (father)	0.3	0.3	0.6	0.3	-0.4	-0.8	-0.5	0.7	0.8	0.1
Diabetes (mother)	1.0	1.2	2.7	-0.8	-0.2	-1.3	-0.7	1.6	1.6	0.8
Severe depression (siblings)	0.7	0.8	3.6	0.3	0.2	-1.0	0.3	0.3	1.9	-0.7
Pack years adult smoking proportion	0.6	0.9	2.5	-0.1	0.3	-1.6	-0.0	0.4	1.1	-1.4
Impedance of leg (right)	0.5	2.4	6.5	0.7	1.5	-1.6	1.3	-0.1	1.8	-2.5
Leg fat-free mass (left)	1.0	5.1	15.5	-1.9	-2.0	0.9	-2.7	2.1	-0.4	3.9
Trunk fat percentage	0.7	3.0	12.7	0.5	0.7	-2.6	0.0	0.7	3.6	-0.3
Hand grip strength (right)	0.1	0.4	1.6	0.5	0.4	-0.3	-0.8	-1.3	0.0	0.4
Townsend deprivation index at recruitment	1.2	1.6	3.9	-2.0	-1.2	-1.4	-1.4	1.2	0.6	-0.2
Current tobacco smoking	0.5	0.8	2.1	-0.9	-1.5	-0.7	-1.1	-0.3	-0.4	0.6
Average weekly fortified wine intake	1.5	1.8	3.6	1.4	0.6	1.9	1.7	-0.7	-1.8	-0.5
Maternal smoking around birth	1.0	1.5	2.7	1.5	1.3	-0.6	1.6	0.6	1.4	-1.1
Fed-up feelings	0.5	0.9	2.3	-1.3	-1.0	0.2	-0.8	-1.5	-0.2	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	5.8	-1.0	0.3	-1.1	0.1	-1.2	2.4	-0.7
Relative age voice broke	0.7	1.0	3.1	-0.7	-1.2	-0.1	-1.0	0.4	-1.8	1.0
Taking other prescription medications	0.9	1.3	2.6	-1.2	-1.3	-1.2	-0.5	1.6	1.2	0.7
Age when periods started (menarche)	0.3	0.8	3.6	-0.4	0.3	0.0	0.0	1.9	1.0	-0.8
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	6.0	-0.8	-1.1	-1.6	-0.7	2.5	1.7	0.3
Heel bone mineral density (BMD) T-score, automated (left)	3.1	7.1	15.8	3.3	3.6	-1.5	2.5	-1.1	-0.1	-4.0
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	3.0	0.7	0.8	-0.8	0.8	-0.2	1.7	-0.8
Qualifications: CSEs or equivalent	1.8	2.4	5.4	-1.2	-2.1	0.2	-1.6	-1.6	-0.2	2.3
Serious illness, injury or assault to yourself	1.5	1.8	5.2	-0.6	-0.5	-2.3	0.2	1.7	2.0	-0.0
High blood pressure	0.7	1.9	5.5	-0.9	-1.1	-2.1	-0.6	2.3	1.0	0.6
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.0	-0.2	-0.6	1.4	-0.5	1.1	-1.2	1.1
Multivitamins +/- minerals	4.0	5.1	8.3	-2.0	-2.9	2.4	-2.3	-0.1	-2.2	2.9
Stomach or abdominal pain in last month	1.1	1.3	5.7	-0.6	0.8	-1.2	0.5	-0.2	2.4	-0.9
Supplements: Glucosamine	2.4	3.1	6.5	-0.9	-2.0	1.1	-1.4	1.2	-2.6	2.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	0.2	-0.1	0.6	-0.3	-0.9	-0.8	-0.2
Medication: Atenolol	1.5	1.9	7.4	-1.1	-0.8	-2.7	-1.4	1.0	-0.9	0.5
Medication: Levothyroxine sodium	0.5	0.9	3.2	1.2	1.0	-0.6	1.8	0.5	0.2	0.2
Sitting height	0.7	5.1	12.7	-2.2	-2.3	1.3	-2.1	1.7	-2.0	3.6
Chronic bronchitis/emphysema (father)	1.0	1.2	5.3	-0.6	-0.6	-0.4	-0.3	2.3	1.3	0.4
High blood pressure (mother)	0.8	1.1	5.1	-0.7	-0.5	-1.1	0.4	0.1	2.3	-0.7
Body mass index (BMI)	0.4	1.7	7.2	-0.2	-0.2	-1.3	-0.8	1.1	2.7	0.8
Impedance of leg (left)	0.4	1.8	4.8	0.9	1.4	-1.2	1.5	-0.7	0.9	-2.2
Leg predicted mass (left)	1.0	5.1	15.2	-1.9	-2.0	0.9	-2.8	2.1	-0.4	3.9
Trunk fat mass	0.4	1.9	7.2	0.0	0.1	-1.8	-0.7	1.3	2.7	1.0
Waist circumference	0.5	1.9	3.8	-0.6	-0.7	-1.4	-1.6	1.3	1.9	1.7
Number of incorrect matches in round	1.2	1.9	2.9	-1.6	-0.9	1.6	-1.0	1.2	-1.7	1.5
Past tobacco smoking	0.5	1.0	2.8	0.9	0.5	1.4	0.9	-1.7	-0.2	-0.5
Alcohol usually taken with meals	1.2	1.9	5.3	1.4	1.1	1.4	1.4	-0.5	-2.3	-0.8
Nervous feelings	0.2	0.4	1.2	-0.4	0.4	-0.4	-0.2	0.6	1.1	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	3.6	-0.7	-0.4	0.1	-0.3	-0.5	1.9	-0.5
Hearing difficulty/problems with background noise	0.5	0.7	2.5	0.3	0.7	0.8	1.6	0.4	0.8	0.8
Hair/balding pattern: Pattern 2	1.0	1.2	4.4	-1.2	-1.2	-0.5	-0.9	2.1	0.4	0.3
Had menopause	0.6	0.7	1.8	-0.9	-1.3	-0.0	-0.5	0.7	0.3	1.3
Had other major operations	3.5	4.2	8.2	2.5	2.1	-1.1	2.9	2.2	1.7	-1.4
Forced vital capacity (FVC)	0.6	2.4	6.2	1.6	2.5	2.4	1.1	-0.6	-0.1	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	3.1	7.0	18.7	2.9	3.4	-2.2	2.1	-1.3	-0.1	-4.3
Ever unenthusiastic/disinterested for a whole week	3.1	3.8	14.1	-0.3	0.5	-2.8	0.4	1.7	3.8	-1.3
Qualifications: None of the above	1.1	2.4	7.5	-0.4	-0.9	-2.2	-0.1	1.8	2.7	0.3
Financial difficulties in last 2 years	0.6	0.8	1.9	-1.0	-0.9	-0.1	-0.6	1.4	1.1	0.4
Mouth/teeth dental problems	0.6	1.0	2.6	1.5	1.2	-0.1	0.7	-1.6	-0.1	-0.3
Heart attack	0.4	0.5	1.3	-0.6	-1.1	-0.8	-0.6	-0.9	0.2	0.3
Allergy	0.5	1.1	2.5	-0.2	0.6	-1.2	0.4	-1.6	1.2	-1.2
Pain all over the body in last month	0.5	0.5	1.0	-1.0	-1.0	0.0	-0.8	0.4	0.2	0.9
Diabetes (self-reported)	0.5	0.7	3.7	0.1	0.5	-1.9	-0.2	-0.5	0.1	-0.9
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.4	-1.5	-1.7	0.6	-1.0	1.9	-0.6	1.4
Medication: Ramipril	0.4	0.5	2.7	-0.6	-0.5	-1.6	-0.3	0.3	0.1	0.4
Medication: Simvastatin	1.1	1.6	3.6	1.6	1.9	-0.1	1.7	1.4	-0.1	-0.2
Fluid intelligence score	0.2	0.5	0.8	0.6	0.6	0.6	0.9	0.6	-0.9	0.2
Illnesses of siblings	0.3	0.4	1.3	-0.3	-0.0	1.1	-0.5	0.8	-0.4	0.3
Neuroticism score	0.3	0.6	2.8	0.5	0.6	1.7	0.8	-0.4	-0.1	-0.4
Weight	0.5	2.6	8.0	-0.9	-1.1	-0.1	-1.9	1.9	1.0	2.8
Impedance of arm (right)	0.3	1.4	4.6	0.2	0.5	-1.4	0.9	-1.3	0.8	-2.1
Arm fat percentage (right)	0.7	2.7	12.5	-0.2	-0.1	-2.4	-0.7	0.6	3.5	-0.1
Trunk fat-free mass	1.6	9.0	25.0	-1.9	-2.6	2.6	-3.1	2.5	-2.4	5.0
Hip circumference	0.3	1.1	3.7	-0.0	-0.1	-1.0	-1.0	0.7	1.9	1.3
Time employed in main current job	1.1	1.2	2.6	-1.6	-0.8	-1.5	-1.6	-0.3	0.3	0.6
Alcohol intake versus 10 years previously	0.8	1.3	2.7	0.6	1.2	-0.5	0.6	1.6	1.6	-1.2
Father’s age at death	1.9	2.5	5.6	1.6	1.7	2.4	2.1	-1.3	-0.5	-0.5
Worrier / anxious feelings	1.1	2.0	7.3	0.7	0.4	2.7	0.8	1.9	-1.4	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.6	-0.6	-0.4	0.3	0.7	1.0	1.6	0.3
Falls in the last year	0.9	1.2	2.8	-1.7	-1.0	-0.9	-1.1	0.9	1.2	0.8
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	-0.7	0.0	-0.7	0.5	0.6	-0.1	-0.4
Number of live births	0.6	0.9	2.8	1.3	0.6	0.0	1.7	-0.1	1.0	-0.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	5.8	1.3	2.4	1.3	0.7	-0.9	0.3	-0.9
Pulse rate	1.7	2.9	7.4	-1.6	-1.8	-2.7	-1.2	1.6	1.7	-0.6
Happiness	0.6	0.7	2.5	-0.9	-0.6	-1.6	-0.8	0.5	0.8	0.1
Noisy workplace	1.8	2.2	7.6	-1.0	-0.1	-1.0	0.1	2.8	2.3	-0.6
Qualifications: A levels/AS levels or equivalent	2.1	4.7	14.1	2.1	1.9	2.3	1.7	-1.3	-3.7	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	6.7	0.1	-0.1	2.6	0.2	-0.2	0.1	0.1
Mouth/teeth dental problems: Dentures	0.7	1.2	2.7	-1.4	-1.6	-0.4	-1.2	0.5	-1.1	0.7
Asthma	1.1	2.2	6.9	0.6	-0.3	2.6	0.9	2.4	-1.3	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.8	-0.8	-0.7	0.8	-0.9	0.6	0.8	0.5
Medication: Cholesterol lowering	0.7	1.1	4.9	-0.9	-0.5	-0.8	-0.6	2.2	-0.5	0.9
Depression (self-reported)	2.6	3.1	8.5	-1.9	-0.6	-2.0	-0.3	2.9	2.3	0.4
Medication: Lansoprazole	4.5	5.1	9.4	-2.7	-3.1	-0.4	-3.0	1.1	0.8	2.8
Prospective memory result	0.1	0.2	0.4	0.1	0.3	-0.4	0.2	-0.6	0.0	-0.7
Lung cancer (father)	1.9	2.2	8.4	0.1	0.4	-2.0	0.2	-0.7	2.9	-1.5
Illnesses of mother	1.1	1.4	3.6	0.7	0.1	1.8	0.1	-1.4	-1.9	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	5.7	1.5	2.4	1.6	0.8	-0.8	0.4	-1.6
Pulse wave Arterial Stiffness index	0.4	0.5	1.8	-0.3	-1.3	0.5	-0.2	-0.0	-0.9	0.6
Impedance of arm (left)	0.2	1.1	2.6	0.5	0.6	-1.3	0.9	-1.4	0.1	-1.6
Arm fat mass (right)	0.6	2.3	7.8	-0.7	-0.7	-1.4	-1.5	1.3	2.8	1.3
Trunk predicted mass	1.6	9.0	25.1	-1.9	-2.6	2.5	-3.1	2.5	-2.4	5.0
Standing height	0.9	8.7	23.5	-1.7	-2.2	2.8	-2.5	1.9	-3.5	4.8
Length of working week for main job	2.5	2.7	5.9	-2.2	-1.6	-0.1	-1.1	2.4	1.5	1.5
Exposure to tobacco smoke at home	1.4	1.6	3.0	-1.7	-0.6	-1.1	-1.6	1.6	1.0	0.7
Breastfed as a baby	0.9	1.1	2.5	0.6	0.5	1.6	1.6	0.1	-1.1	1.0
Tense / ‘highly strung’	0.2	0.3	1.5	0.3	0.1	-0.3	0.3	-0.5	0.6	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	3.5	0.1	0.9	-0.8	0.7	1.7	1.9	-0.7
Hair/balding pattern: Pattern 4	0.5	1.2	4.3	0.4	1.4	-0.7	-0.4	-2.1	0.5	-1.0
Birth weight of first child	0.7	1.4	2.1	-1.0	-1.3	0.8	-0.8	-1.4	-1.2	1.3
Peak expiratory flow (PEF)	0.4	0.9	3.1	1.2	1.8	0.7	0.4	-0.9	0.5	-0.3
Pulse wave reflection index	0.3	0.4	1.8	-0.1	0.1	1.3	-0.1	-0.1	-0.8	0.8
Ever highly irritable/argumentative for 2 days	0.8	1.0	4.8	1.0	0.5	-0.4	0.5	0.3	2.2	-0.7
Loud music exposure frequency	2.3	2.5	12.0	-0.2	0.9	-2.1	0.3	0.4	3.5	-0.7
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	7.6	0.9	0.8	2.7	0.6	-0.5	-2.8	-0.0
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	4.4	1.6	1.8	0.6	1.8	0.1	1.6	-2.1
Blood clot in the leg (DVT)	0.6	0.7	4.1	0.2	-0.5	-2.0	-0.3	-0.2	0.8	0.0
Medication: Paracetamol	0.9	1.6	2.6	-1.5	-1.4	-0.3	-1.2	1.4	1.6	0.7
Headache pain in last month	0.5	0.9	2.1	0.9	1.2	1.1	1.5	0.1	0.6	-0.8
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	6.2	1.1	0.8	1.4	0.7	-2.5	-0.7	-0.6
Glaucoma (self-reported)	0.2	0.2	1.0	-0.1	-0.2	-0.5	0.1	0.4	1.0	-0.3
Gout (self-reported)	1.0	1.4	3.5	0.8	1.3	-1.1	0.5	-1.1	1.2	-1.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.9	1.6	1.0	0.4	2.0	-0.1	-0.8	-0.3
Medication: Amlodipine	0.6	0.8	1.5	0.7	1.1	-0.2	1.2	1.2	0.8	-0.6
Medication: Ventolin 100micrograms inhaler	1.2	1.5	9.1	0.4	0.2	-0.3	0.5	3.0	0.9	0.5
Birth weight	0.2	0.4	1.2	0.0	-0.4	0.9	-0.5	0.1	-1.1	0.2
Chronic bronchitis/emphysema (mother)	3.2	3.7	8.0	-1.7	-2.4	-1.9	-2.8	-0.1	-1.0	2.2
High blood pressure (siblings)	0.2	0.3	1.0	0.6	-0.0	-0.6	0.5	-1.0	0.6	-0.3
Forced vital capacity (FVC), Best measure	0.6	2.2	5.5	1.5	2.4	2.2	0.8	-0.6	-0.0	-1.2
Body fat percentage	0.8	3.2	13.7	0.4	0.6	-2.7	-0.1	0.7	3.7	-0.3
Leg fat percentage (right)	1.2	4.3	18.1	0.5	0.8	-2.9	0.1	1.3	4.2	-1.0
Arm fat-free mass (right)	1.4	7.0	22.1	-1.8	-2.2	1.5	-2.9	2.6	-1.1	4.7
Exposure to tobacco smoke outside home	2.9	3.9	6.0	-2.5	-1.7	-1.2	-2.0	2.4	1.9	1.8
Comparative body size at age 10	0.3	0.8	2.4	0.1	0.6	1.3	0.3	1.6	0.1	0.8
Number of full brothers	0.4	0.6	2.1	-0.4	-1.0	0.8	0.2	1.4	0.3	0.1
Worry too long after embarrassment	0.2	0.4	2.4	-0.1	0.2	0.1	-0.5	-1.5	-0.5	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.1	-1.1	0.3	0.2	-0.2	1.5	1.3	0.6
Wheeze or whistling in the chest in last year	0.8	1.5	7.7	-0.1	-0.7	0.5	0.4	2.8	1.0	0.8
Number of children fathered	0.8	0.9	1.8	1.2	1.0	-0.6	0.8	0.7	-1.0	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.5	-0.6	-0.2	-0.7	-0.1	1.6	0.2	0.8
Age at first live birth	0.4	0.8	4.2	0.1	0.1	1.1	0.0	0.2	-2.1	0.3
Pulse wave peak to peak time	0.2	0.3	1.1	-0.0	1.0	-0.4	-0.1	0.4	0.7	-0.2
Health satisfaction	2.4	3.2	6.3	-2.5	-2.4	-1.9	-2.1	0.4	0.2	1.3
Shortness of breath walking on level ground	1.9	2.3	4.5	-1.3	-2.0	-0.9	-1.8	1.1	-0.3	2.1
Qualifications: College or University degree	0.6	1.9	5.4	1.2	1.6	0.9	1.0	-1.0	-2.3	-1.1
Eye problems/disorders: None of the above	1.3	1.5	2.6	0.5	0.1	1.6	1.5	1.6	0.9	1.5
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.5	0.9	0.6	1.2	0.0	-0.4	-1.0	-0.1
Emphysema/chronic bronchitis	0.4	0.4	1.4	-0.4	-0.2	0.4	-0.3	0.9	0.5	1.2
Medication for pain relief, constipation, heartburn	0.4	0.6	1.4	0.6	0.8	0.9	0.2	-1.0	-1.2	-0.1
Neck or shoulder pain in last month	0.3	0.5	1.6	0.2	1.0	-0.3	0.3	0.2	1.3	-0.7
Medication: Blood pressure	1.0	1.7	4.7	-1.2	-1.0	-1.4	-0.6	2.2	1.0	1.1
Angina (self-reported)	0.5	0.7	1.5	-1.1	-0.5	0.3	-0.7	1.1	0.5	1.2
Migraine (self-reported)	1.3	1.7	4.2	-2.0	-1.0	-1.1	-1.1	1.6	1.0	0.7
Medication: Ibuprofen	0.5	0.6	1.6	-0.6	-0.4	1.3	-0.4	0.5	0.8	0.9
Medication: Allopurinol	0.6	0.8	2.0	0.8	1.4	-1.0	0.4	-0.4	0.6	-1.2
Medication: Omeprazole	2.0	2.4	6.7	-1.6	-2.1	-1.3	-1.1	0.0	-0.5	2.6
Medication: Seretide 50 evohaler	0.3	0.3	1.1	-0.3	-0.5	1.1	0.0	0.6	0.6	0.5
Mean time to correctly identify matches	0.9	1.7	6.3	-0.7	-0.4	-1.7	0.4	1.2	2.5	-0.9
Heart disease (mother)	1.0	1.2	2.9	1.2	1.7	1.0	1.5	0.9	0.1	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.0	1.1	1.2	1.4	1.1	-1.2	-0.1	-0.3
Whole body fat mass	0.5	2.1	7.4	-0.3	-0.3	-1.7	-1.2	1.4	2.7	1.1
Leg fat mass (right)	0.7	2.6	10.4	-0.3	0.1	-2.0	-0.9	1.6	3.2	0.5
Arm predicted mass (right)	1.3	6.7	20.9	-1.9	-2.2	1.4	-2.7	2.6	-1.0	4.6
Pulse rate, automated reading	0.7	2.1	8.3	-1.2	-1.5	-0.8	-0.4	2.9	1.0	0.9
Alcohol intake frequency.	0.7	1.5	4.1	-0.9	-2.0	-0.2	-1.3	-0.8	-0.0	1.8
Comparative height size at age 10	1.1	6.0	18.6	-1.7	-2.5	1.3	-2.5	1.4	-2.1	4.3
Number of full sisters	1.7	2.1	5.2	-1.3	-1.4	-2.0	-1.2	0.1	2.3	0.5
Suffer from ‘nerves’	0.3	0.4	1.3	-0.4	0.2	-0.5	-0.4	-1.1	0.9	-0.4
Overall health rating	0.4	0.9	2.0	-1.2	-0.9	0.0	-0.7	0.9	1.4	1.1
Chest pain or discomfort	0.9	1.2	2.7	0.8	0.8	-0.3	1.6	1.4	1.6	-0.3
Had major operations	0.2	0.3	1.0	-0.4	0.3	-0.4	-0.5	1.0	0.3	-0.4
Age at last live birth	0.5	0.7	3.9	0.2	0.1	0.9	0.2	0.6	-2.0	0.1
Family relationship satisfaction	1.1	1.3	3.5	0.5	1.3	-0.8	1.0	0.1	1.9	-1.5
Leg pain on walking	1.0	1.2	2.1	-1.3	-1.4	-0.5	-1.4	-1.1	-0.8	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	4.2	1.4	2.1	-1.6	1.4	-0.1	1.4	-1.9
Commuting to job workplace: Car/motor vehicle	0.8	0.9	5.3	0.6	-0.2	2.3	0.0	0.6	0.1	0.5
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	6.6	0.2	1.1	-0.6	0.0	-2.6	-0.6	-0.7
Medication: Aspirin	0.5	0.6	1.2	0.8	0.7	-1.1	1.1	0.5	0.1	-0.6
Supplements: Vitamin C	0.3	0.3	1.1	-0.7	0.5	-0.2	0.3	1.1	0.1	0.6
Knee pain experienced in last month	0.5	0.7	2.4	0.0	0.1	0.2	-0.9	-1.1	-1.5	0.8
Hypertension (Self-reported)	0.5	1.5	3.9	-0.7	-0.8	-2.0	-0.3	2.0	1.0	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	5.1	5.9	13.2	-2.6	-3.6	-0.6	-3.2	0.7	-1.4	2.9
Illnesses of father: Heart disease	1.5	2.1	4.4	1.8	2.1	-0.2	1.8	1.2	0.1	-1.5
Illnesses of siblings: Diabetes	0.5	0.6	1.4	0.8	1.2	-0.8	1.0	-0.1	0.4	-0.8
Smoking status: Previous	0.2	0.3	1.1	0.3	0.6	-0.6	-0.0	1.0	0.2	0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	5.5	-1.1	-0.9	2.3	-1.5	1.3	-1.3	1.9
Whole body fat-free mass	1.4	7.8	23.6	-1.9	-2.5	2.0	-3.0	2.3	-1.7	4.9
Leg fat-free mass (right)	1.0	5.4	17.8	-1.7	-2.1	1.4	-2.7	1.6	-1.1	4.2
Arm fat percentage (left)	0.6	2.4	10.8	0.1	0.1	-2.3	-0.6	0.5	3.3	0.0
Average weekly red wine intake	1.1	1.6	6.7	0.9	0.5	0.1	0.3	-1.7	-2.6	-0.7
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.5	0.2	-0.1	0.5	0.1	-0.3	-0.7	-0.2
Mood swings	0.2	0.4	1.4	-0.2	-0.5	1.2	-0.1	-1.0	0.3	0.1
Loneliness, isolation	0.3	0.5	1.5	-1.2	-0.1	0.6	-0.7	0.1	-0.4	0.8
Long-standing illness, disability or infirmity	0.4	0.6	1.8	-0.2	-0.3	0.5	-0.2	1.3	1.0	0.8
Ever had bowel cancer screening	2.1	2.4	5.6	2.4	1.4	1.0	2.3	0.8	-0.5	-1.4
Diabetes diagnosed by doctor	0.7	1.1	5.6	0.1	0.4	-2.4	-0.0	-0.1	0.6	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.9	1.0	0.6	0.1	0.4	-0.1	-0.6	-0.9
Friendships satisfaction	2.0	2.4	5.2	2.0	2.2	-0.3	2.3	0.7	0.9	-1.3
Qualifications: nursing, teaching	1.9	2.9	6.6	-2.6	-2.1	-0.7	-2.1	1.5	0.5	1.2
Commuting to job workplace: Walk	0.7	0.7	1.6	-0.9	-0.1	-1.3	-0.0	-0.6	1.2	-1.0
Eye problems/disorders: Cataract	1.1	1.3	5.9	0.5	0.6	0.0	-0.2	-1.3	-2.4	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.9	-1.5	-1.4	-0.3	-0.3	1.7	-0.2	1.3
Medication for cholesterol	0.2	0.3	1.0	-0.3	0.3	0.2	-0.6	-0.3	-1.0	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.9	-0.5	0.1	0.2	-0.0	-1.4	0.4	0.1
Back pain experienced in last month	2.1	3.0	4.5	-1.9	-2.0	0.7	-2.1	-0.2	-2.1	2.0
Mineral and other dietary supplements	1.9	2.6	4.4	1.4	1.5	-0.8	1.4	-2.0	1.7	-2.1
Breast cancer (self-reported)	0.3	0.3	1.1	0.1	0.2	-1.0	0.2	-0.7	-0.6	-0.6
Asthma (self-reported)	0.9	1.9	5.8	0.7	-0.1	2.4	0.9	2.2	-1.1	0.5
Osteoporosis (self-reported)	1.8	2.3	4.0	-0.9	-1.7	1.7	-1.0	1.0	-1.8	2.0
Osteoarthritis (self-reported)	2.0	2.6	4.3	1.5	1.7	2.0	2.1	1.4	0.0	-1.6
Medication: Aspirin	0.7	0.8	2.0	1.0	0.9	-1.1	1.4	0.5	0.0	-0.9
Medication: Gliclazide	0.3	0.3	0.8	-0.4	0.0	-0.7	-0.3	0.9	0.8	-0.5
Illnesses of father: None of the above (group 1)	1.0	1.2	2.4	-1.5	-1.4	0.3	-1.2	0.4	-0.3	1.5
Smoking status: Current	0.9	1.4	3.5	-1.5	-1.9	-0.8	-1.5	0.0	-0.5	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	4.4	0.7	1.3	-1.1	0.4	-1.2	1.1	-2.1
Whole body water mass	1.3	7.5	22.3	-2.0	-2.4	1.9	-3.1	2.3	-1.5	4.7
Leg predicted mass (right)	1.0	5.2	17.4	-1.7	-2.0	1.4	-2.6	1.5	-1.1	4.2
Arm fat mass (left)	0.5	2.0	6.7	-0.4	-0.4	-1.3	-1.3	1.3	2.6	1.4
Number of self-reported non-cancer illnesses	0.8	1.4	4.3	-0.9	-0.5	-1.0	-0.1	2.1	1.9	0.0
Average weekly champagne plus white wine intake	0.6	0.8	2.3	-0.0	-0.1	1.2	-0.0	1.4	-1.5	0.6
Miserableness	0.1	0.1	0.4	-0.2	0.4	0.6	0.4	0.3	0.3	0.3
Guilty feelings	0.4	0.6	1.2	0.3	0.6	0.9	1.1	-1.0	-0.0	-0.7
Wears glasses or contact lenses	0.8	0.9	3.3	-0.7	-0.9	1.1	-0.5	0.1	-1.8	0.6
Ever taken oral contraceptive pill	0.5	0.5	1.5	-0.0	-0.5	0.9	-0.5	1.2	-0.9	0.0
Hearing aid user	0.5	0.5	1.9	-0.2	-0.0	-0.8	-0.7	-0.7	1.4	-0.2
Mother’s age at death	0.9	1.2	4.9	0.4	-0.1	1.1	1.0	0.8	-2.2	0.5
Financial situation satisfaction	0.7	0.9	3.3	0.9	0.2	1.1	0.6	1.8	0.0	0.7
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.7	-0.1	0.1	-0.7	-0.8	-0.1	0.1	0.6
Commuting to job workplace: Public transport	0.2	0.3	0.7	-0.1	0.7	-0.8	0.2	-0.4	0.6	-0.1
Eye problems/disorders: Glaucoma	0.5	0.6	1.3	-0.7	-0.6	-1.0	-1.0	-0.3	1.1	-0.2
Medication: Blood pressure	0.4	0.7	2.0	-0.5	-1.4	-0.8	-0.0	1.3	0.6	0.5
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.8	0.0	-0.2	0.2	-0.3	0.0	-0.9	0.5
Supplements: Fish oil (including cod liver oil)	1.9	2.5	4.5	-0.7	-0.9	1.9	-0.7	1.8	-2.1	2.0
High cholesterol (Self-reported)	0.9	1.6	2.9	0.5	1.5	0.0	1.7	1.7	0.4	-1.6
Medication: Bendroflumethiazide	0.3	0.5	1.6	-0.7	-0.6	-0.1	-0.9	0.5	-0.4	1.3
Medication: Paracetamol	1.0	1.5	4.1	-1.3	-0.7	-0.8	-0.8	1.8	2.0	0.3
Medication: Lisinopril	1.3	1.6	4.3	1.3	1.2	-0.8	2.1	0.9	0.7	-1.4
Medication: Atorvastatin	0.7	0.8	2.7	-1.1	-0.9	-0.9	-0.4	1.6	-0.2	-0.2
Illnesses of father: High blood pressure	0.6	0.7	3.0	-0.0	0.1	-0.3	1.0	-0.8	1.7	-0.6
Alcohol drinker status: Never	0.4	0.5	2.1	1.4	0.4	-0.1	0.9	-0.1	-0.5	-0.4
Ever smoked	0.9	1.5	6.6	-0.8	-0.4	-1.7	-0.3	2.6	0.6	0.2
Basal metabolic rate	1.1	6.3	19.9	-1.8	-2.1	1.6	-2.8	2.2	-1.0	4.5
Leg fat percentage (left)	0.9	3.2	13.1	0.6	0.7	-2.6	0.2	1.0	3.6	-0.7
Arm fat-free mass (left)	1.3	6.8	19.6	-2.1	-2.2	1.6	-2.8	2.8	-0.4	4.4
Number of operations (self-reported)	2.4	3.6	15.1	0.1	0.9	-2.3	1.0	3.9	1.6	-0.8
Average weekly beer plus cider intake	1.2	1.7	2.9	1.0	1.2	1.5	1.4	-1.5	1.7	-0.6
Irritability	0.4	0.7	3.7	0.4	0.4	1.9	0.3	0.9	0.2	-0.3
Risk taking	2.7	3.9	6.7	-2.6	-2.3	1.1	-2.5	1.4	0.3	2.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.8	-0.1	-0.3	-0.2	-0.3	-0.9	-0.0	0.1
Fractured/broken bones in last 5 years	1.2	1.6	3.8	-1.3	-1.9	0.6	0.3	1.3	-0.5	1.8
Age started oral contraceptive pill	0.2	0.3	1.3	0.0	0.5	-0.6	0.3	1.1	0.1	-0.3
Diastolic blood pressure, automated reading	0.8	2.4	8.5	-1.3	-0.3	-2.9	-1.5	1.9	0.9	-0.3
Ever depressed for a whole week	3.7	4.6	21.9	-0.5	-0.5	-2.1	0.0	2.1	4.7	-0.9
Unable to work because of sickness or disability	2.2	2.8	7.2	-2.2	-1.0	-0.7	-1.8	0.6	2.7	1.6
Commuting to job workplace: Cycle	1.3	1.5	3.4	1.6	1.8	0.6	0.8	-1.1	-1.6	-0.3
Myopia	1.7	2.5	8.2	1.3	0.7	2.0	1.6	0.8	-2.9	0.5
Vascular/heart problems diagnosed by doctor	0.6	1.7	4.2	0.9	1.0	1.8	0.6	-2.0	-1.3	-0.6
Cholesterol lowering medication	0.7	1.1	3.2	0.6	0.7	0.1	1.8	1.5	1.0	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	4.8	-1.5	-2.1	-1.1	-0.9	0.7	0.1	2.2
Pain experienced in last month	0.3	0.5	2.0	-0.0	0.2	-1.4	0.0	0.3	1.1	-0.5
Supplements: Calcium	2.6	2.8	8.8	-1.7	-1.3	0.2	-1.6	3.0	-0.6	1.9
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.1	0.4	-0.4	0.2	-0.2	0.1	-0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	-0.6	-1.1	-0.6	-0.7	-0.5	0.1	0.5
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	4.7	-0.2	-0.9	-2.2	-0.7	-0.2	0.6	0.3
Heart disease (siblings)	0.8	1.0	4.7	-0.5	0.3	-1.2	0.1	-0.1	2.2	-0.4
Alcohol drinker status: Previous	2.5	2.9	6.8	-2.1	-2.6	-0.0	-1.8	0.1	-0.7	2.2
Pack years of smoking	0.8	1.1	3.0	0.3	0.6	-1.7	0.4	0.0	1.2	-1.6
Impedance of whole body	0.3	1.4	3.7	0.5	0.9	-1.4	1.3	-1.0	0.8	-1.9
Leg fat mass (left)	0.6	2.3	8.3	-0.4	-0.1	-1.9	-1.0	1.6	2.9	0.8
Arm predicted mass (left)	1.3	6.8	19.6	-2.1	-2.3	1.4	-3.0	2.7	-0.5	4.4