Hub : Genes

INTS4L2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.068	0.026	6.6e-10	0.072	0.087	0.057	0.086	0.071	3.9e-09	9.6e-11	1.8e-07	1.3e-10	5.1e-09
2	GTEx	Brain Cerebellum	0.176	0.078	5.6e-05	0.138	NA	0.148	NA	0.121	7.3e-05	NA	4.0e-05	NA	2.0e-04
3	GTEx	Testis	0.258	0.135	9.1e-06	0.097	NA	0.096	NA	0.073	4.3e-05	NA	4.8e-05	NA	3.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	4.2	6.6	7.8	-2.8	-2.7	2.2
Bipolar Disorder or Schizophrenia	1.1	2.7	3.2	-1.8	-1.4	1.7
Depressed Affect (Nagel 2018)	0.4	0.8	1.1	-0.7	-0.8	1.0
Depression (Nagel 2018)	0.1	0.2	0.5	0.1	-0.2	0.7
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.4	-1.8	-0.5	0.5
Neuroticism (Nagel 2018)	0.5	1.2	1.5	-1.2	-1.0	1.1
Schizophrenia (2018)	0.0	0.1	0.1	-0.0	0.3	0.2
Schizophrenia vs Biploar Disorder	2.3	3.0	3.5	1.9	1.9	-1.4
Worry (Nagel 2018)	0.1	0.2	0.4	-0.3	-0.7	0.3
Alzheimer’s Disease (in mother)	0.5	0.6	1.2	0.4	1.1	-0.6
Alzheimer’s Disease (in father)	0.1	0.1	0.4	0.1	-0.2	0.6
Alzheimer’s Disease (including proxy)	0.4	0.6	1.0	0.8	1.0	-0.5
Crohns Disease (2017)	0.2	0.4	0.6	0.3	-0.7	0.8
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	0.6	0.1	0.4
Ulcerative Colitis (UC)	0.1	0.2	0.2	0.5	0.3	0.5
Major Depression (MDD)	1.1	1.4	1.6	-1.1	-1.3	1.2
Reaction Time	0.0	0.1	0.2	0.5	-0.3	0.1
Verbal and Numeric Reasoning (VNR)	2.2	5.2	11.7	-3.4	-1.6	1.2
Breast Cancer	1.9	4.7	6.2	2.2	2.5	-1.7
Ovarian Cancer	0.1	0.1	0.2	-0.1	0.1	-0.4
Prostate Cancer	0.3	0.5	1.2	-1.1	-0.5	0.2
Age at First Birth	3.6	5.2	6.6	-2.0	-2.6	2.2
Bipolar Disorder (2011)	0.9	0.9	2.0	-1.4	-0.8	0.1
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	-0.1	-0.1	-0.1
Coronary Artery Disease (CAD)	0.0	0.1	0.1	0.3	-0.1	0.2
Crohns Disease (2012)	2.3	3.6	5.2	-1.4	-2.3	1.9
Mean Putamen Volume	0.9	1.0	1.4	1.0	0.9	-1.2
Fasting Glucose	0.6	0.7	2.1	-0.1	0.0	1.5
HbA1C	0.7	0.7	1.2	-0.3	-0.9	1.1
HDL Cholesterol	0.1	0.1	0.2	0.5	-0.3	0.2
LDL Cholesterol	0.8	1.2	1.8	1.0	0.9	-1.4
Lupus	1.3	2.0	3.8	-2.0	-1.4	0.3
Neuroticism (2016)	0.0	0.0	0.0	0.1	0.1	-0.1
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.1	0.3	-0.4
Rheumatoid Arthritis	1.2	1.7	2.2	1.5	0.8	-1.5
Schizophrenia (2014)	0.1	0.2	0.4	0.1	0.7	-0.4
Triglycerides	1.7	2.8	4.7	-2.2	-1.3	1.4
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.4	-0.6	-0.6	0.3
Ulcerative Colitis	0.2	0.3	0.8	-0.2	-0.3	0.9
Blood Eosinophil Count	0.0	0.2	0.7	0.8	0.1	-0.2
Blood Platelet Count	1.4	15.7	21.2	4.6	3.9	-3.3
Blood Red Count	0.1	1.0	1.8	-1.1	-1.4	0.4
Blood White Count	0.9	7.0	18.1	4.2	1.5	0.8
Heel T-Score	0.6	5.1	7.7	-2.8	-2.4	1.3
BMI	0.0	0.1	0.1	0.1	-0.1	0.4
Height	0.9	16.9	24.9	5.0	4.0	-3.1
Waist Hip Ratio (WHR)	0.0	0.2	0.5	0.7	0.2	-0.3
Systolic Blood Pressure	0.4	1.9	2.2	1.5	1.2	-1.4
Smoking Status	0.0	0.1	0.1	-0.2	-0.1	0.3
Allergy or Eczema	0.5	1.4	2.2	-0.4	-1.3	1.5
Cardiovascular Disease	0.1	0.4	0.7	0.7	0.8	-0.1
Hypothyroidism (self reported)	0.3	0.7	1.0	0.8	1.0	-0.7
Respiratory disease	0.0	0.0	0.0	0.1	0.2	-0.2
Type 2 Diabetes (T2D) (2018)	0.8	1.6	3.9	2.0	0.9	-0.1
Lung FEV1/FVC ratio	0.2	1.2	2.0	1.4	1.1	-0.6
Lung FVC	3.3	16.9	26.7	-5.2	-4.0	2.8
Neuroticism	0.5	1.1	1.5	-1.2	-0.9	1.0
Chronotype (morning person)	0.3	0.7	1.1	1.1	0.8	-0.6
Hair Pigment	0.1	1.5	2.2	-1.5	-1.0	1.0
Tanning	0.2	3.0	4.9	-2.2	-1.9	0.6
Hand grip strength (left)	0.0	0.1	0.3	0.3	0.5	-0.1
Number of treatments/medications taken	0.0	0.1	0.1	0.4	-0.0	-0.2
Average weekly spirits intake	1.0	1.3	1.8	1.4	1.1	-0.8
Sensitivity / hurt feelings	0.1	0.1	0.2	0.3	-0.0	0.5
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	-0.0	-0.2	0.6
Hearing difficulty/problems: Yes	1.4	2.1	4.9	-2.2	-0.9	0.7
Relative age of first facial hair	3.1	6.4	8.3	-2.2	-2.9	2.4
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	4.3	-2.1	-0.7	0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.4	0.4	0.0
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	0.0	0.7	-0.4
Systolic blood pressure, automated reading	0.1	0.3	0.4	0.5	0.6	-0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.5	0.1	-0.1
Angina	0.3	0.4	0.7	-0.8	-0.4	0.5
Medication for hormone replacement therapy	0.3	0.4	1.1	-1.1	-0.2	-0.1
Vitamin and mineral supplements	0.4	0.5	0.7	-0.6	-0.8	0.7
Supplements: Zinc	0.3	0.4	0.6	-0.7	0.2	-0.7
Medication: Co-codamol	1.0	1.2	2.8	-1.7	-0.8	0.2
Medication: Metformin	0.8	1.2	2.7	1.6	0.9	0.0
Diabetes (father)	0.2	0.3	0.5	0.7	0.4	0.3
Diabetes (mother)	0.1	0.1	0.4	-0.6	0.1	-0.2
Severe depression (siblings)	0.1	0.1	0.2	-0.4	0.2	0.0
Pack years adult smoking proportion	1.5	2.4	3.1	-1.8	-1.5	1.3
Impedance of leg (right)	0.5	2.2	4.6	2.1	1.2	-0.8
Leg fat-free mass (left)	0.5	2.7	3.7	1.7	1.9	-1.2
Trunk fat percentage	0.2	0.8	1.2	1.1	1.1	-0.0
Hand grip strength (right)	0.0	0.1	0.3	-0.0	-0.2	0.5
Townsend deprivation index at recruitment	0.2	0.3	0.6	0.6	0.8	-0.1
Current tobacco smoking	0.6	1.0	1.7	-0.7	-1.3	0.9
Average weekly fortified wine intake	0.8	0.9	1.7	-1.3	-0.8	0.7
Maternal smoking around birth	0.3	0.5	0.8	0.2	0.9	0.8
Fed-up feelings	0.1	0.2	0.3	-0.2	-0.3	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	0.6	0.3	0.3
Relative age voice broke	0.3	0.5	1.2	-0.4	-0.4	-1.1
Taking other prescription medications	0.8	1.3	1.8	-0.9	-1.1	1.4
Age when periods started (menarche)	0.0	0.0	0.0	-0.1	-0.0	-0.1
Bilateral oophorectomy (both ovaries removed)	0.0	0.1	0.1	-0.3	-0.1	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	-0.2	-0.1	-0.7
Tinnitus: Yes, but not now, but have in the past	4.1	4.4	6.1	1.4	2.5	-2.2
Qualifications: CSEs or equivalent	1.1	1.5	2.3	0.7	1.5	-1.2
Serious illness, injury or assault to yourself	0.3	0.4	0.4	-0.6	0.7	-0.7
High blood pressure	0.1	0.2	0.4	0.1	-0.3	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	0.3	-0.6	0.9
Multivitamins +/- minerals	0.1	0.2	0.5	-0.1	0.1	-0.7
Stomach or abdominal pain in last month	0.0	0.1	0.1	0.1	-0.2	-0.3
Supplements: Glucosamine	0.0	0.0	0.1	-0.3	-0.2	0.0
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.1	-1.1	-1.8	1.1
Medication: Atenolol	0.3	0.4	0.5	-0.3	-0.7	0.7
Medication: Levothyroxine sodium	1.0	1.7	2.1	1.2	1.3	-1.5
Sitting height	0.2	1.4	2.2	1.1	1.5	-0.8
Chronic bronchitis/emphysema (father)	0.8	1.0	1.5	-1.0	-1.2	0.7
High blood pressure (mother)	0.1	0.1	0.1	-0.1	0.3	-0.3
Body mass index (BMI)	0.0	0.0	0.1	-0.2	0.1	0.2
Impedance of leg (left)	0.6	2.8	5.3	2.3	1.5	-0.9
Leg predicted mass (left)	0.5	2.9	4.0	1.7	2.0	-1.3
Trunk fat mass	0.5	2.0	2.9	1.7	1.6	-0.6
Waist circumference	0.3	1.1	2.0	1.4	1.1	-0.5
Number of incorrect matches in round	0.2	0.4	0.5	0.5	0.7	-0.7
Past tobacco smoking	0.2	0.3	0.5	0.5	0.3	-0.7
Alcohol usually taken with meals	3.8	6.1	7.5	-2.7	-2.7	1.9
Nervous feelings	0.5	1.0	1.4	-0.8	-1.0	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	-1.2	-0.4	-0.2
Hearing difficulty/problems with background noise	2.0	3.2	4.5	-2.1	-1.8	1.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.0	-0.5	0.4
Had menopause	1.4	1.8	3.0	-0.7	-1.4	1.7
Had other major operations	0.2	0.2	0.5	-0.7	-0.1	0.3
Forced vital capacity (FVC)	0.1	0.5	0.8	-0.7	-0.4	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.1	-0.3	-0.1	-0.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.8	-0.0	0.6	-0.9
Qualifications: None of the above	3.2	6.9	10.3	3.2	2.3	-2.3
Financial difficulties in last 2 years	0.5	0.7	1.1	-0.6	1.0	-0.9
Mouth/teeth dental problems	0.8	1.2	2.3	1.5	1.1	-0.3
Heart attack	0.1	0.1	0.3	-0.0	-0.3	0.6
Allergy	0.2	0.5	1.2	0.3	1.1	-0.5
Pain all over the body in last month	1.4	1.6	2.4	1.1	1.0	-1.6
Diabetes (self-reported)	0.8	1.3	2.2	1.5	1.1	-0.6
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.2	-0.3	0.4
Medication: Ramipril	0.7	0.8	1.8	0.5	-0.7	1.4
Medication: Simvastatin	0.5	0.7	1.7	1.3	0.4	0.6
Fluid intelligence score	1.5	3.1	6.8	-2.6	-0.9	1.2
Illnesses of siblings	0.2	0.3	0.4	0.4	0.4	-0.6
Neuroticism score	0.5	1.0	1.5	-1.2	-0.8	0.8
Weight	0.4	1.8	2.7	1.6	1.5	-0.7
Impedance of arm (right)	0.1	0.4	0.6	0.8	0.7	0.3
Arm fat percentage (right)	0.0	0.1	0.2	0.1	0.4	0.2
Trunk fat-free mass	0.5	3.1	3.7	1.9	1.7	-1.6
Hip circumference	0.4	1.7	2.3	1.4	1.5	-0.9
Time employed in main current job	0.7	0.8	1.3	1.1	-0.4	-0.9
Alcohol intake versus 10 years previously	2.5	3.7	6.1	-2.5	-1.6	1.6
Father’s age at death	1.0	1.3	1.6	1.1	1.0	-1.3
Worrier / anxious feelings	0.5	0.9	1.5	-0.5	-1.0	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.5	0.7	0.5	-0.6
Falls in the last year	0.5	0.6	1.0	-1.0	-0.7	0.7
Hair/balding pattern: Pattern 3	0.3	0.5	1.1	1.1	0.5	0.3
Number of live births	4.3	6.1	8.5	2.9	2.3	-2.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.5	-0.5	-0.2	0.7
Pulse rate	3.4	5.7	9.7	3.1	2.5	-1.2
Happiness	0.5	0.6	1.2	-1.1	0.1	-0.7
Noisy workplace	0.2	0.2	0.4	0.4	-0.1	-0.6
Qualifications: A levels/AS levels or equivalent	0.6	1.4	1.8	-1.4	-1.1	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.4	-1.6	-0.1	-0.4
Mouth/teeth dental problems: Dentures	3.2	5.4	9.7	-3.1	-2.0	1.6
Asthma	0.0	0.0	0.1	-0.1	0.0	-0.4
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	1.9	-1.1	-1.4	1.0
Medication: Cholesterol lowering	0.0	0.1	0.2	-0.0	0.4	0.0
Depression (self-reported)	0.8	1.0	1.0	-1.0	-1.0	1.0
Medication: Lansoprazole	0.3	0.3	0.6	0.8	0.1	-0.6
Prospective memory result	1.5	1.8	3.7	1.9	0.9	-0.9
Lung cancer (father)	3.0	3.5	5.1	1.1	2.0	-2.3
Illnesses of mother	0.3	0.3	0.6	0.6	-0.8	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.6	-0.8	-0.3	0.7
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.3	-0.2	0.5
Impedance of arm (left)	0.1	0.4	0.6	0.6	0.2	0.8
Arm fat mass (right)	0.1	0.5	0.7	0.8	0.9	-0.1
Trunk predicted mass	0.6	3.1	3.7	1.9	1.8	-1.6
Standing height	0.9	9.0	13.7	3.7	3.1	-1.9
Length of working week for main job	1.0	1.1	2.8	-1.7	-0.7	0.0
Exposure to tobacco smoke at home	0.1	0.1	0.4	0.6	-0.0	-0.2
Breastfed as a baby	0.2	0.3	0.8	-0.9	-0.2	-0.0
Tense / ‘highly strung’	0.0	0.0	0.1	-0.0	0.3	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.6	-0.7	-1.3	1.1
Hair/balding pattern: Pattern 4	0.3	0.8	1.6	-0.6	0.6	-1.3
Birth weight of first child	0.2	0.4	0.8	0.2	0.9	0.7
Peak expiratory flow (PEF)	0.3	0.8	2.0	-0.3	0.6	-1.4
Pulse wave reflection index	2.1	2.6	3.6	-1.9	-1.8	0.9
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.3	-0.7	-0.9	1.2
Loud music exposure frequency	1.3	1.4	2.2	0.9	1.1	-1.5
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	2.4	-1.6	-1.0	1.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.3	0.3	0.6	-0.6
Blood clot in the leg (DVT)	0.4	0.5	1.1	-0.4	-0.5	-1.0
Medication: Paracetamol	0.4	0.6	1.0	-0.0	-1.0	1.0
Headache pain in last month	0.2	0.3	0.6	-0.5	-0.8	-0.2
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	0.2	-0.4	0.1
Glaucoma (self-reported)	0.1	0.1	0.2	0.3	-0.5	0.0
Gout (self-reported)	0.1	0.2	0.5	-0.3	0.1	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.4	0.5	0.6	-0.5
Medication: Amlodipine	1.3	1.8	2.8	1.1	1.7	-1.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.8	0.7	0.9	-0.5
Birth weight	0.2	0.5	0.7	0.8	0.8	0.3
Chronic bronchitis/emphysema (mother)	2.3	2.7	4.7	2.2	1.8	-0.6
High blood pressure (siblings)	0.0	0.1	0.1	0.2	0.2	-0.3
Forced vital capacity (FVC), Best measure	0.4	1.3	2.0	-1.4	-0.9	1.0
Body fat percentage	0.3	1.1	1.6	1.3	1.2	-0.5
Leg fat percentage (right)	0.2	0.8	1.3	1.2	0.9	-0.5
Arm fat-free mass (right)	0.8	4.2	5.8	2.4	2.0	-1.7
Exposure to tobacco smoke outside home	0.8	1.1	1.5	1.2	0.8	-1.0
Comparative body size at age 10	0.5	1.4	2.3	1.5	1.0	-0.9
Number of full brothers	1.7	2.1	4.3	-2.1	-1.1	0.8
Worry too long after embarrassment	0.3	0.5	1.2	-1.1	-0.3	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	0.7	-0.8	-0.8	0.6
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	0.0	0.4	-0.9
Number of children fathered	2.8	3.2	3.3	-1.8	-1.8	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.7	1.0	1.3	-0.5
Age at first live birth	2.0	3.5	4.0	-1.9	-2.0	1.7
Pulse wave peak to peak time	0.1	0.1	0.2	0.3	0.2	-0.4
Health satisfaction	1.5	2.0	2.5	1.5	1.6	-1.0
Shortness of breath walking on level ground	0.3	0.4	1.0	1.0	0.2	0.2
Qualifications: College or University degree	0.6	1.8	4.3	-2.1	-1.0	0.3
Eye problems/disorders: None of the above	0.2	0.3	0.6	-0.8	0.3	-0.4
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.8	0.3	0.7	-1.4
Emphysema/chronic bronchitis	0.3	0.3	0.9	0.9	0.0	-0.2
Medication for pain relief, constipation, heartburn	0.4	0.7	1.4	0.2	1.2	-0.8
Neck or shoulder pain in last month	0.1	0.2	0.3	-0.3	-0.3	-0.5
Medication: Blood pressure	0.3	0.4	0.8	-0.6	-0.4	0.9
Angina (self-reported)	0.3	0.4	0.6	-0.8	-0.4	0.5
Migraine (self-reported)	2.5	3.2	6.1	-2.5	-1.7	0.8
Medication: Ibuprofen	0.0	0.0	0.1	-0.1	-0.3	0.0
Medication: Allopurinol	0.3	0.4	0.5	-0.6	-0.7	0.5
Medication: Omeprazole	0.6	0.7	2.1	-0.2	-0.1	1.5
Medication: Seretide 50 evohaler	2.6	3.0	4.0	1.6	1.6	-2.0
Mean time to correctly identify matches	0.1	0.1	0.3	0.6	-0.2	-0.1
Heart disease (mother)	1.5	1.9	2.7	-1.6	-1.2	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.6	5.5	7.6	1.6	2.7	-2.6
Whole body fat mass	0.6	2.5	3.3	1.8	1.8	-0.9
Leg fat mass (right)	0.6	2.3	3.2	1.8	1.7	-1.0
Arm predicted mass (right)	1.0	5.1	6.7	2.6	2.2	-1.9
Pulse rate, automated reading	1.2	3.9	6.7	2.6	2.1	-0.9
Alcohol intake frequency.	1.2	2.9	5.5	-2.4	-1.7	0.4
Comparative height size at age 10	2.1	11.6	15.0	3.9	3.8	-2.2
Number of full sisters	0.1	0.1	0.2	0.1	0.3	-0.4
Suffer from ‘nerves’	0.1	0.2	0.3	0.4	-0.5	0.2
Overall health rating	1.6	3.4	6.4	2.5	1.6	-1.1
Chest pain or discomfort	1.8	2.6	3.6	-1.1	-1.7	1.9
Had major operations	2.1	2.5	3.0	1.4	1.7	-1.6
Age at last live birth	0.2	0.3	0.6	-0.8	-0.3	0.1
Family relationship satisfaction	0.6	0.8	1.2	-0.9	0.4	-1.1
Leg pain on walking	0.2	0.3	0.9	0.9	0.1	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.8	0.9	0.4	-0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.6	0.4	-0.1
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	4.8	2.2	0.2	0.2
Medication: Aspirin	0.0	0.1	0.1	-0.3	-0.3	0.2
Supplements: Vitamin C	0.8	0.9	1.4	-1.0	-0.6	1.2
Knee pain experienced in last month	0.6	1.0	1.8	1.4	0.9	-0.5
Hypertension (Self-reported)	0.0	0.1	0.2	0.4	-0.1	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.0	-0.3	-0.7	1.7
Illnesses of father: Heart disease	0.1	0.2	0.3	0.1	0.4	-0.5
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.3	0.5	-0.2
Smoking status: Previous	0.6	0.9	1.5	1.0	1.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	5.2	2.0	2.3	-1.6
Whole body fat-free mass	0.5	3.1	3.7	1.9	1.9	-1.4
Leg fat-free mass (right)	0.5	2.5	3.6	1.5	1.9	-1.2
Arm fat percentage (left)	0.0	0.1	0.1	0.3	0.4	0.3
Average weekly red wine intake	1.1	1.7	2.9	1.0	1.1	-1.7
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.4	0.4	0.7	-0.6
Mood swings	0.6	1.1	1.9	-0.7	-1.0	1.4
Loneliness, isolation	0.8	1.1	3.2	-1.8	-0.4	-0.1
Long-standing illness, disability or infirmity	1.4	2.2	2.9	-1.4	-1.7	1.3
Ever had bowel cancer screening	0.1	0.1	0.3	-0.1	-0.6	0.1
Diabetes diagnosed by doctor	1.0	1.6	4.0	2.0	0.9	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.8	-0.9	-0.3	-0.6
Friendships satisfaction	0.7	0.8	1.2	-1.1	-1.1	0.4
Qualifications: nursing, teaching	1.4	2.2	5.7	-2.4	-0.7	0.5
Commuting to job workplace: Walk	0.9	0.9	1.1	-0.9	-1.0	1.0
Eye problems/disorders: Cataract	1.0	1.1	1.9	1.2	-0.2	1.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	-0.1	0.0	-0.5
Medication for cholesterol	0.1	0.1	0.4	-0.7	-0.0	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	4.3	2.1	1.0	-1.0
Back pain experienced in last month	1.8	2.7	3.9	-1.2	-2.0	1.6
Mineral and other dietary supplements	0.1	0.2	0.3	-0.5	-0.4	0.3
Breast cancer (self-reported)	0.4	0.4	0.7	0.1	0.8	-0.8
Asthma (self-reported)	0.0	0.1	0.1	-0.2	-0.0	-0.4
Osteoporosis (self-reported)	0.3	0.3	0.6	-0.5	-0.3	0.8
Osteoarthritis (self-reported)	0.3	0.3	0.7	0.9	0.5	-0.2
Medication: Aspirin	0.0	0.0	0.0	0.2	0.2	-0.2
Medication: Gliclazide	0.2	0.2	0.5	0.7	0.2	0.0
Illnesses of father: None of the above (group 1)	1.8	2.2	2.8	1.7	1.5	-1.3
Smoking status: Current	0.6	0.9	1.7	-0.7	-1.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	2.7	-1.6	-1.5	1.4
Whole body water mass	0.5	3.0	3.5	1.9	1.8	-1.4
Leg predicted mass (right)	0.5	2.4	3.6	1.5	1.9	-1.1
Arm fat mass (left)	0.1	0.2	0.4	0.6	0.6	0.1
Number of self-reported non-cancer illnesses	0.2	0.4	0.7	-0.8	-0.4	0.4
Average weekly champagne plus white wine intake	3.3	4.5	6.4	-2.5	-2.1	1.6
Miserableness	0.1	0.3	0.7	-0.8	-0.0	0.3
Guilty feelings	1.7	2.5	5.5	-2.3	-1.1	0.9
Wears glasses or contact lenses	4.6	5.2	6.4	-2.4	-1.9	2.5
Ever taken oral contraceptive pill	0.5	0.6	1.3	0.0	-0.7	1.2
Hearing aid user	0.4	0.4	1.0	1.0	0.4	-0.1
Mother’s age at death	0.5	0.7	1.8	-1.3	-0.5	-0.1
Financial situation satisfaction	0.4	0.5	0.8	0.9	0.8	-0.3
Tinnitus: Yes, now most or all of the time	1.0	1.2	1.7	-1.3	-1.3	0.5
Commuting to job workplace: Public transport	1.6	1.9	4.3	-2.1	-0.9	0.9
Eye problems/disorders: Glaucoma	0.7	0.8	1.7	1.3	0.3	-0.8
Medication: Blood pressure	0.5	0.9	2.3	1.5	0.6	-0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.1	-1.5	-0.7	0.2
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	0.4	-0.2	0.2
High cholesterol (Self-reported)	0.1	0.2	0.4	-0.3	-0.2	0.6
Medication: Bendroflumethiazide	0.5	0.8	1.4	1.2	1.0	-0.2
Medication: Paracetamol	0.2	0.3	0.4	0.6	-0.5	0.4
Medication: Lisinopril	0.6	0.8	1.4	-0.8	-0.6	1.2
Medication: Atorvastatin	0.5	0.6	0.7	0.7	0.8	-0.9
Illnesses of father: High blood pressure	0.1	0.2	0.2	0.5	0.4	0.4
Alcohol drinker status: Never	0.3	0.4	0.9	-0.4	-1.0	0.1
Ever smoked	3.9	6.8	7.0	-2.6	-2.5	2.6
Basal metabolic rate	0.6	3.4	4.3	2.1	2.0	-1.4
Leg fat percentage (left)	0.2	0.8	1.3	1.1	0.9	-0.6
Arm fat-free mass (left)	0.8	4.0	4.8	2.2	2.0	-1.8
Number of operations (self-reported)	1.5	2.2	4.0	-0.1	1.6	-2.0
Average weekly beer plus cider intake	1.0	1.4	2.2	-1.1	-1.0	1.5
Irritability	1.2	2.1	3.5	-1.9	-1.2	1.1
Risk taking	0.4	0.6	1.6	0.2	1.3	-0.2
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.8	-0.9	-0.4	-0.8
Fractured/broken bones in last 5 years	0.4	0.5	1.1	-1.1	-0.5	0.1
Age started oral contraceptive pill	1.6	2.0	3.6	-0.8	-1.3	1.9
Diastolic blood pressure, automated reading	2.0	6.3	8.0	2.7	2.8	-1.9
Ever depressed for a whole week	1.0	1.2	1.5	0.8	1.2	-1.2
Unable to work because of sickness or disability	1.6	2.0	2.6	1.6	1.4	-1.3
Commuting to job workplace: Cycle	0.2	0.3	0.5	-0.6	-0.7	-0.0
Myopia	0.6	0.9	1.9	-0.6	-0.7	1.4
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.3	0.2	0.2	-0.6
Cholesterol lowering medication	0.5	0.7	1.8	1.4	-0.3	0.5
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.5	-0.3	-0.3	1.9
Pain experienced in last month	0.3	0.5	1.2	0.6	1.1	0.1
Supplements: Calcium	1.5	1.7	3.0	-0.7	-1.2	1.7
Basal cell carcinoma (self-reported)	0.5	0.6	1.2	1.1	0.4	-0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	-0.2	-0.5	0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.6	-0.6	-0.7	-0.8
Heart disease (siblings)	0.7	0.8	1.4	-0.6	-1.2	0.8
Alcohol drinker status: Previous	0.6	0.7	1.0	-1.0	-0.5	1.0
Pack years of smoking	1.9	2.7	3.3	-1.8	-1.7	1.5
Impedance of whole body	0.2	0.9	2.0	1.4	0.8	-0.0
Leg fat mass (left)	0.7	2.7	3.6	1.9	1.8	-1.1
Arm predicted mass (left)	0.9	4.3	5.4	2.3	2.1	-1.8